diff --git a/lldb/source/Host/posix/MainLoopPosix.cpp b/lldb/source/Host/posix/MainLoopPosix.cpp
index c6fe7814bd22e..2d95100ffe7e6 100644
--- a/lldb/source/Host/posix/MainLoopPosix.cpp
+++ b/lldb/source/Host/posix/MainLoopPosix.cpp
@@ -107,6 +107,11 @@ class MainLoopPosix::RunImpl {
 
 #if HAVE_SYS_EVENT_H
   std::vector<struct kevent> in_events;
+  enum FDState : bool {
+    eFDStateReading = false,
+    eFDStateEOF = true,
+  };
+  std::map<int, FDState> eof_fds;
   struct kevent out_events[4];
   int num_events = -1;
 
@@ -123,8 +128,12 @@ MainLoopPosix::RunImpl::RunImpl(MainLoopPosix &loop) : loop(loop) {
 Status MainLoopPosix::RunImpl::Poll() {
   in_events.resize(loop.m_read_fds.size());
   unsigned i = 0;
-  for (auto &fd : loop.m_read_fds)
-    EV_SET(&in_events[i++], fd.first, EVFILT_READ, EV_ADD, 0, 0, 0);
+  for (auto &fd : loop.m_read_fds) {
+    if (eof_fds.find(fd.first) == eof_fds.end())
+      eof_fds[fd.first] = eFDStateReading;
+    EV_SET(&in_events[i++], fd.first, EVFILT_READ,
+           eof_fds[fd.first] == eFDStateEOF ? EV_DELETE : EV_ADD, 0, 0, 0);
+  }
 
   num_events =
       kevent(loop.m_kqueue, in_events.data(), in_events.size(), out_events,
@@ -149,6 +158,10 @@ void MainLoopPosix::RunImpl::ProcessReadEvents() {
     switch (out_events[i].filter) {
     case EVFILT_READ:
       loop.ProcessReadObject(out_events[i].ident);
+      // A read event with `data == 0` indicates the file has reached EOF and is
+      // closed. Remember this to prevent triggering the callback again.
+      if (out_events[i].data == 0)
+        eof_fds[out_events[i].ident] = eFDStateEOF;
       break;
     default:
       llvm_unreachable("Unknown event");
diff --git a/lldb/unittests/Host/MainLoopTest.cpp b/lldb/unittests/Host/MainLoopTest.cpp
index 8a248100c936a..d16e0ee508de3 100644
--- a/lldb/unittests/Host/MainLoopTest.cpp
+++ b/lldb/unittests/Host/MainLoopTest.cpp
@@ -104,6 +104,52 @@ TEST_F(MainLoopTest, ReadPipeObject) {
   ASSERT_EQ(1u, callback_count);
 }
 
+TEST_F(MainLoopTest, ReadAcrossMultipleRuns) {
+  Pipe pipe;
+
+  ASSERT_TRUE(pipe.CreateNew().Success());
+
+  MainLoop loop;
+
+  char X = 'X';
+  size_t len = sizeof(X);
+  ASSERT_THAT_EXPECTED(pipe.Write(&X, len), llvm::HasValue(1));
+
+  Status error;
+  auto handle = loop.RegisterReadObject(
+      std::make_shared<NativeFile>(pipe.GetReadFileDescriptor(),
+                                   File::eOpenOptionReadOnly, false),
+      make_callback(), error);
+  ASSERT_TRUE(error.Success());
+  ASSERT_TRUE(handle);
+
+  // Callback invoked once per 'Run' since data is not consumed.
+  ASSERT_TRUE(loop.Run().Success());
+  ASSERT_TRUE(loop.Run().Success());
+  ASSERT_EQ(2u, callback_count);
+
+  // Consume buffer, so next 'Run' should NOT trigger the handle.
+  char buf[10];
+  ASSERT_THAT_EXPECTED(pipe.Read(buf, sizeof(buf)), llvm::HasValue(1));
+  loop.AddCallback([](auto &loop) { loop.RequestTermination(); },
+                   std::chrono::milliseconds(10));
+
+  // This run operation should NOT trigger the read handle, since the data has
+  // already been consumed.
+  ASSERT_TRUE(loop.Run().Success());
+  ASSERT_EQ(2u, callback_count);
+
+  // Close the write side of the pair to ensure we have a callback for the
+  // hangup.
+  pipe.CloseWriteFileDescriptor();
+  ASSERT_TRUE(loop.Run().Success());
+  ASSERT_EQ(3u, callback_count);
+
+  // The file handle is still registered, so it will trigger the handle again.
+  ASSERT_TRUE(loop.Run().Success());
+  ASSERT_EQ(4u, callback_count);
+}
+
 TEST_F(MainLoopTest, MultipleReadsPipeObject) {
   Pipe pipe;
 
@@ -501,12 +547,15 @@ TEST_F(MainLoopTest, DetectsEOF) {
 
   Status error;
   MainLoop loop;
-  auto handle =
-      loop.RegisterReadObject(conn->GetReadObject(), make_callback(), error);
+  auto handle = loop.RegisterReadObject(
+      conn->GetReadObject(), [&](auto &loop) { callback_count++; }, error);
+  loop.AddCallback([](MainLoopBase &loop) { loop.RequestTermination(); },
+                   std::chrono::milliseconds(100));
   ASSERT_TRUE(error.Success());
   term.CloseSecondaryFileDescriptor();
 
   ASSERT_TRUE(loop.Run().Success());
+  // Ensure we only receive one event for the EOF event.
   ASSERT_EQ(1u, callback_count);
 }