diff --git a/llvm/lib/Analysis/MemoryBuiltins.cpp b/llvm/lib/Analysis/MemoryBuiltins.cpp
index a329f9ae24c13..4410b3f0a38e9 100644
--- a/llvm/lib/Analysis/MemoryBuiltins.cpp
+++ b/llvm/lib/Analysis/MemoryBuiltins.cpp
@@ -1045,7 +1045,8 @@ OffsetSpan ObjectSizeOffsetVisitor::visitGlobalAlias(GlobalAlias &GA) {
 OffsetSpan ObjectSizeOffsetVisitor::visitGlobalVariable(GlobalVariable &GV) {
   if (!GV.getValueType()->isSized() || GV.hasExternalWeakLinkage() ||
       ((!GV.hasInitializer() || GV.isInterposable()) &&
-       Options.EvalMode != ObjectSizeOpts::Mode::Min))
+       Options.EvalMode != ObjectSizeOpts::Mode::Min) ||
+      !isUIntN(IntTyBits, GV.getGlobalSize(DL)))
     return ObjectSizeOffsetVisitor::unknown();
 
   APInt Size(IntTyBits, GV.getGlobalSize(DL));
diff --git a/llvm/test/Transforms/DeadStoreElimination/large-global-var.ll b/llvm/test/Transforms/DeadStoreElimination/large-global-var.ll
new file mode 100644
index 0000000000000..2a485fc2419e5
--- /dev/null
+++ b/llvm/test/Transforms/DeadStoreElimination/large-global-var.ll
@@ -0,0 +1,21 @@
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py UTC_ARGS: --version 6
+; RUN: opt < %s -passes=dse -S | FileCheck %s
+
+target datalayout = "e-m:e-p:32:32-i8:8-i32:32-i64:64"
+
+; The data-layout only allows 32-bit indexing, but the array is too large to be
+; fully accessible through that index-space.
+@G = internal global [39969271929 x i32] zeroinitializer, align 4
+
+define void @func() {
+; CHECK-LABEL: define void @func() {
+; CHECK-NEXT:  [[ENTRY:.*:]]
+; CHECK-NEXT:    store i32 0, ptr getelementptr (i8, ptr @G, i64 24), align 4
+; CHECK-NEXT:    store i32 0, ptr getelementptr (i8, ptr @G, i64 20), align 4
+; CHECK-NEXT:    ret void
+;
+entry:
+  store i32 0, ptr getelementptr (i8, ptr @G, i64 24), align 4
+  store i32 0, ptr getelementptr (i8, ptr @G, i64 20), align 4
+  ret void
+}