diff --git a/lldb/include/lldb/Expression/IRExecutionUnit.h b/lldb/include/lldb/Expression/IRExecutionUnit.h
index 58f12bf8b64f5..10bd1a0f46cf0 100644
--- a/lldb/include/lldb/Expression/IRExecutionUnit.h
+++ b/lldb/include/lldb/Expression/IRExecutionUnit.h
@@ -17,6 +17,7 @@
 #include "llvm/ExecutionEngine/SectionMemoryManager.h"
 #include "llvm/IR/Module.h"
 
+#include "lldb/Core/ModuleList.h"
 #include "lldb/Expression/IRMemoryMap.h"
 #include "lldb/Expression/ObjectFileJIT.h"
 #include "lldb/Symbol/SymbolContext.h"
@@ -161,6 +162,12 @@ class IRExecutionUnit : public std::enable_shared_from_this<IRExecutionUnit>,
     return m_jitted_global_variables;
   }
 
+  void AppendPreferredSymbolContexts(SymbolContextList const &contexts) {
+    for (auto const &ctx : contexts)
+      if (ctx.module_sp)
+        m_preferred_modules.Append(ctx.module_sp);
+  }
+
 private:
   /// Look up the object in m_address_map that contains a given address, find
   /// where it was copied to, and return the remote address at the same offset
@@ -396,6 +403,11 @@ class IRExecutionUnit : public std::enable_shared_from_this<IRExecutionUnit>,
   ///< defining no functions using that variable, would do this.)  If this
   ///< is true, any allocations need to be committed immediately -- no
   ///< opportunity for relocation.
+
+  ///< Any Module in this list will be used for symbol/function lookup
+  ///< before any other module (except for the module corresponding to the
+  ///< current frame).
+  ModuleList m_preferred_modules;
 };
 
 } // namespace lldb_private
diff --git a/lldb/include/lldb/Target/Target.h b/lldb/include/lldb/Target/Target.h
index f31ac381391b4..98273fb7e1c97 100644
--- a/lldb/include/lldb/Target/Target.h
+++ b/lldb/include/lldb/Target/Target.h
@@ -25,6 +25,7 @@
 #include "lldb/Core/UserSettingsController.h"
 #include "lldb/Expression/Expression.h"
 #include "lldb/Host/ProcessLaunchInfo.h"
+#include "lldb/Symbol/SymbolContext.h"
 #include "lldb/Symbol/TypeSystem.h"
 #include "lldb/Target/ExecutionContextScope.h"
 #include "lldb/Target/PathMappingList.h"
@@ -332,6 +333,14 @@ class EvaluateExpressionOptions {
     m_language = SourceLanguage(language_type);
   }
 
+  void SetPreferredSymbolContexts(SymbolContextList contexts) {
+    m_preferred_lookup_contexts = std::move(contexts);
+  }
+
+  const SymbolContextList &GetPreferredSymbolContexts() const {
+    return m_preferred_lookup_contexts;
+  }
+
   /// Set the language using a pair of language code and version as
   /// defined by the DWARF 6 specification.
   /// WARNING: These codes may change until DWARF 6 is finalized.
@@ -500,6 +509,11 @@ class EvaluateExpressionOptions {
   // originates
   mutable std::string m_pound_line_file;
   mutable uint32_t m_pound_line_line = 0;
+
+  ///< During expression evaluation, any SymbolContext in this list will be
+  ///< used for symbol/function lookup before any other context (except for
+  ///< the module corresponding to the current frame).
+  SymbolContextList m_preferred_lookup_contexts;
 };
 
 // Target
diff --git a/lldb/source/Expression/IRExecutionUnit.cpp b/lldb/source/Expression/IRExecutionUnit.cpp
index c8b4ddf705ec4..06b0cb7769f64 100644
--- a/lldb/source/Expression/IRExecutionUnit.cpp
+++ b/lldb/source/Expression/IRExecutionUnit.cpp
@@ -52,7 +52,7 @@ IRExecutionUnit::IRExecutionUnit(std::unique_ptr<llvm::LLVMContext> &context_up,
       m_cpu_features(cpu_features), m_name(name), m_sym_ctx(sym_ctx),
       m_did_jit(false), m_function_load_addr(LLDB_INVALID_ADDRESS),
       m_function_end_load_addr(LLDB_INVALID_ADDRESS),
-      m_reported_allocations(false) {}
+      m_reported_allocations(false), m_preferred_modules() {}
 
 lldb::addr_t IRExecutionUnit::WriteNow(const uint8_t *bytes, size_t size,
                                        Status &error) {
@@ -782,8 +782,11 @@ IRExecutionUnit::FindInSymbols(const std::vector<ConstString> &names,
   }
 
   ModuleList non_local_images = target->GetImages();
-  // We'll process module_sp separately, before the other modules.
+  // We'll process module_sp and any preferred modules separately, before the
+  // other modules.
   non_local_images.Remove(sc.module_sp);
+  for (size_t i = 0; i < m_preferred_modules.GetSize(); ++i)
+    non_local_images.Remove(m_preferred_modules.GetModuleAtIndex(i));
 
   LoadAddressResolver resolver(target, symbol_was_missing_weak);
 
@@ -794,9 +797,11 @@ IRExecutionUnit::FindInSymbols(const std::vector<ConstString> &names,
   for (const ConstString &name : names) {
     // The lookup order here is as follows:
     // 1) Functions in `sc.module_sp`
-    // 2) Functions in the other modules
-    // 3) Symbols in `sc.module_sp`
-    // 4) Symbols in the other modules
+    // 2) Functions in the preferred modules list
+    // 3) Functions in the other modules
+    // 4) Symbols in `sc.module_sp`
+    // 5) Symbols in the preferred modules list
+    // 6) Symbols in the other modules
     if (sc.module_sp) {
       SymbolContextList sc_list;
       sc.module_sp->FindFunctions(name, CompilerDeclContext(),
@@ -806,6 +811,14 @@ IRExecutionUnit::FindInSymbols(const std::vector<ConstString> &names,
         return *load_addr;
     }
 
+    {
+      SymbolContextList sc_list;
+      m_preferred_modules.FindFunctions(name, lldb::eFunctionNameTypeFull,
+                                        function_options, sc_list);
+      if (auto load_addr = resolver.Resolve(sc_list))
+        return *load_addr;
+    }
+
     {
       SymbolContextList sc_list;
       non_local_images.FindFunctions(name, lldb::eFunctionNameTypeFull,
@@ -822,6 +835,14 @@ IRExecutionUnit::FindInSymbols(const std::vector<ConstString> &names,
         return *load_addr;
     }
 
+    {
+      SymbolContextList sc_list;
+      m_preferred_modules.FindSymbolsWithNameAndType(name, lldb::eSymbolTypeAny,
+                                                     sc_list);
+      if (auto load_addr = resolver.Resolve(sc_list))
+        return *load_addr;
+    }
+
     {
       SymbolContextList sc_list;
       non_local_images.FindSymbolsWithNameAndType(name, lldb::eSymbolTypeAny,
diff --git a/lldb/source/Plugins/ExpressionParser/Clang/ClangExpressionParser.cpp b/lldb/source/Plugins/ExpressionParser/Clang/ClangExpressionParser.cpp
index f1573bae2651b..5a78ce8fa7688 100644
--- a/lldb/source/Plugins/ExpressionParser/Clang/ClangExpressionParser.cpp
+++ b/lldb/source/Plugins/ExpressionParser/Clang/ClangExpressionParser.cpp
@@ -1539,6 +1539,10 @@ lldb_private::Status ClangExpressionParser::DoPrepareForExecution(
       function_name, exe_ctx.GetTargetSP(), sc,
       m_compiler->getTargetOpts().Features);
 
+  if (auto *options = m_expr.GetOptions())
+    execution_unit_sp->AppendPreferredSymbolContexts(
+        options->GetPreferredSymbolContexts());
+
   ClangExpressionHelper *type_system_helper =
       dyn_cast<ClangExpressionHelper>(m_expr.GetTypeSystemHelper());
   ClangExpressionDeclMap *decl_map =
diff --git a/lldb/source/Plugins/InstrumentationRuntime/Utility/CMakeLists.txt b/lldb/source/Plugins/InstrumentationRuntime/Utility/CMakeLists.txt
index dcca47fb0e253..705fe1503fae2 100644
--- a/lldb/source/Plugins/InstrumentationRuntime/Utility/CMakeLists.txt
+++ b/lldb/source/Plugins/InstrumentationRuntime/Utility/CMakeLists.txt
@@ -1,5 +1,6 @@
 add_lldb_library(lldbPluginInstrumentationRuntimeUtility
   ReportRetriever.cpp
+  Utility.cpp
 
   LINK_LIBS
     lldbBreakpoint
diff --git a/lldb/source/Plugins/InstrumentationRuntime/Utility/ReportRetriever.cpp b/lldb/source/Plugins/InstrumentationRuntime/Utility/ReportRetriever.cpp
index d61c59776eee6..96489248022eb 100644
--- a/lldb/source/Plugins/InstrumentationRuntime/Utility/ReportRetriever.cpp
+++ b/lldb/source/Plugins/InstrumentationRuntime/Utility/ReportRetriever.cpp
@@ -7,6 +7,7 @@
 //===----------------------------------------------------------------------===//
 
 #include "ReportRetriever.h"
+#include "Utility.h"
 
 #include "lldb/Breakpoint/StoppointCallbackContext.h"
 #include "lldb/Core/Debugger.h"
@@ -82,6 +83,12 @@ ReportRetriever::RetrieveReportData(const ProcessSP process_sp) {
   options.SetAutoApplyFixIts(false);
   options.SetLanguage(eLanguageTypeObjC_plus_plus);
 
+  if (auto m = GetPreferredAsanModule(process_sp->GetTarget())) {
+    SymbolContextList sc_list;
+    sc_list.Append(SymbolContext(std::move(m)));
+    options.SetPreferredSymbolContexts(std::move(sc_list));
+  }
+
   ValueObjectSP return_value_sp;
   ExecutionContext exe_ctx;
   frame_sp->CalculateExecutionContext(exe_ctx);
diff --git a/lldb/source/Plugins/InstrumentationRuntime/Utility/Utility.cpp b/lldb/source/Plugins/InstrumentationRuntime/Utility/Utility.cpp
new file mode 100644
index 0000000000000..3cbd03b24297a
--- /dev/null
+++ b/lldb/source/Plugins/InstrumentationRuntime/Utility/Utility.cpp
@@ -0,0 +1,35 @@
+//===-- Utility.cpp -------------------------------------------------------===//
+//
+// Part of the LLVM Project, under the Apache License v2.0 with LLVM Exceptions.
+// See https://llvm.org/LICENSE.txt for license information.
+// SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception
+//
+//===----------------------------------------------------------------------===//
+
+#include "Utility.h"
+
+#include "lldb/Core/Module.h"
+#include "lldb/Target/Target.h"
+
+namespace lldb_private {
+
+///< On Darwin, if LLDB loaded libclang_rt, it's coming from a locally built
+///< compiler-rt, and we should prefer it in favour of the system sanitizers.
+///< This helper searches the target for such a dylib. Returns nullptr if no
+///< such dylib was found.
+lldb::ModuleSP GetPreferredAsanModule(const Target &target) {
+  lldb::ModuleSP module;
+  llvm::Regex pattern(R"(libclang_rt\.asan_.*_dynamic\.dylib)");
+  target.GetImages().ForEach([&](const lldb::ModuleSP &m) {
+    if (pattern.match(m->GetFileSpec().GetFilename().GetStringRef())) {
+      module = m;
+      return false;
+    }
+
+    return true;
+  });
+
+  return module;
+}
+
+} // namespace lldb_private
diff --git a/lldb/source/Plugins/InstrumentationRuntime/Utility/Utility.h b/lldb/source/Plugins/InstrumentationRuntime/Utility/Utility.h
new file mode 100644
index 0000000000000..813a0c107989e
--- /dev/null
+++ b/lldb/source/Plugins/InstrumentationRuntime/Utility/Utility.h
@@ -0,0 +1,27 @@
+//===-- Utility.h -----------------------------------------------*- C++ -*-===//
+//
+// Part of the LLVM Project, under the Apache License v2.0 with LLVM Exceptions.
+// See https://llvm.org/LICENSE.txt for license information.
+// SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception
+//
+//===----------------------------------------------------------------------===//
+
+#ifndef LLDB_SOURCE_PLUGINS_INSTRUMENTATIONRUNTIME_UTILITY_UTILITY_H
+#define LLDB_SOURCE_PLUGINS_INSTRUMENTATIONRUNTIME_UTILITY_UTILITY_H
+
+#include "lldb/lldb-forward.h"
+
+namespace lldb_private {
+
+class Target;
+
+///< On Darwin, if LLDB loaded libclang_rt, it's coming from a locally built
+///< compiler-rt, and we should prefer it in favour of the system sanitizers
+///< when running InstrumentationRuntime utility expressions that use symbols
+///< from the sanitizer libraries. This helper searches the target for such a
+///< dylib. Returns nullptr if no such dylib was found.
+lldb::ModuleSP GetPreferredAsanModule(const Target &target);
+
+} // namespace lldb_private
+
+#endif // LLDB_SOURCE_PLUGINS_INSTRUMENTATIONRUNTIME_UTILITY_UTILITY_H
diff --git a/lldb/source/Plugins/MemoryHistory/asan/MemoryHistoryASan.cpp b/lldb/source/Plugins/MemoryHistory/asan/MemoryHistoryASan.cpp
index 41df0e85199ce..afaaa57b09587 100644
--- a/lldb/source/Plugins/MemoryHistory/asan/MemoryHistoryASan.cpp
+++ b/lldb/source/Plugins/MemoryHistory/asan/MemoryHistoryASan.cpp
@@ -8,8 +8,10 @@
 
 #include "MemoryHistoryASan.h"
 
+#include "lldb/Symbol/SymbolContext.h"
 #include "lldb/Target/MemoryHistory.h"
 
+#include "Plugins/InstrumentationRuntime/Utility/Utility.h"
 #include "Plugins/Process/Utility/HistoryThread.h"
 #include "lldb/Core/Debugger.h"
 #include "lldb/Core/Module.h"
@@ -174,6 +176,12 @@ HistoryThreads MemoryHistoryASan::GetHistoryThreads(lldb::addr_t address) {
   options.SetAutoApplyFixIts(false);
   options.SetLanguage(eLanguageTypeObjC_plus_plus);
 
+  if (auto m = GetPreferredAsanModule(process_sp->GetTarget())) {
+    SymbolContextList sc_list;
+    sc_list.Append(SymbolContext(std::move(m)));
+    options.SetPreferredSymbolContexts(std::move(sc_list));
+  }
+
   ExpressionResults expr_result = UserExpression::Evaluate(
       exe_ctx, options, expr.GetString(), "", return_value_sp);
   if (expr_result != eExpressionCompleted) {