diff --git a/pkg/plugins/scorer/no_hit_lru.go b/pkg/plugins/scorer/no_hit_lru.go
index 417cf05a56..a367caa349 100644
--- a/pkg/plugins/scorer/no_hit_lru.go
+++ b/pkg/plugins/scorer/no_hit_lru.go
@@ -21,6 +21,12 @@ const (
 
 	// defaultLRUSize is the maximum number of pods we'll consider in the cache
 	defaultLRUSize = 1024
+
+	// defaultPrefillProfile is the name of the prefill profile
+	//
+	// This is currently hardcoded until we have a defined proper config interface.
+	// (See also https://github.com/kubernetes-sigs/gateway-api-inference-extension/pull/2104/	)
+	defaultPrefillProfile = "prefill"
 )
 
 // compile-time type assertions
@@ -286,19 +292,23 @@ func (s *NoHitLRU) PreRequest(ctx context.Context, request *types.LLMRequest, sc
 		return
 	}
 
-	// Get the primary profile's target pod
-	primaryProfile := schedulingResult.ProfileResults[schedulingResult.PrimaryProfileName]
-	if primaryProfile == nil || len(primaryProfile.TargetPods) == 0 {
-		logger.Info("No target pod in primary profile")
-		return
+	if targetProfile, ok := schedulingResult.ProfileResults[schedulingResult.PrimaryProfileName]; ok && targetProfile != nil && len(targetProfile.TargetPods) != 0 {
+		s.moveTargetPodToFront(ctx, request, targetProfile, schedulingResult.PrimaryProfileName)
+	}
+	if targetProfile, ok := schedulingResult.ProfileResults[defaultPrefillProfile]; ok && targetProfile != nil && len(targetProfile.TargetPods) != 0 {
+		s.moveTargetPodToFront(ctx, request, targetProfile, defaultPrefillProfile)
 	}
+}
+
+func (s *NoHitLRU) moveTargetPodToFront(ctx context.Context, request *types.LLMRequest, targetProfile *types.ProfileRunResult, profileName string) {
+	logger := log.FromContext(ctx).V(logutil.DEBUG)
 
-	targetPod := primaryProfile.TargetPods[0]
+	targetPod := targetProfile.TargetPods[0]
 	podName := targetPod.GetPod().NamespacedName.String()
 
 	// Move the pod to the front of the LRU.
 	var present struct{} // dummy value
 	s.lruCache.Add(podName, present)
 
-	logger.Info("Updated LRU cache for cold request", "pod", podName, "requestId", request.RequestId)
+	logger.Info("Updated LRU cache for cold request", "profile", profileName, "pod", podName, "requestId", request.RequestId)
 }
diff --git a/pkg/plugins/scorer/no_hit_lru_test.go b/pkg/plugins/scorer/no_hit_lru_test.go
index 6890c998cb..a03dd3aae2 100644
--- a/pkg/plugins/scorer/no_hit_lru_test.go
+++ b/pkg/plugins/scorer/no_hit_lru_test.go
@@ -455,3 +455,120 @@ func TestNoHitLRUEdgeCases(t *testing.T) {
 		}
 	})
 }
+
+func TestNoHitLRUPrefillDecodeTracking(t *testing.T) {
+	// Prefill worker pods
+	prefillPodA := &types.PodMetrics{
+		Pod:          &backend.Pod{NamespacedName: k8stypes.NamespacedName{Name: "prefill-a", Namespace: "default"}},
+		MetricsState: &backendmetrics.MetricsState{},
+	}
+	prefillPodB := &types.PodMetrics{
+		Pod:          &backend.Pod{NamespacedName: k8stypes.NamespacedName{Name: "prefill-b", Namespace: "default"}},
+		MetricsState: &backendmetrics.MetricsState{},
+	}
+
+	// Decode worker pods
+	decodePodA := &types.PodMetrics{
+		Pod:          &backend.Pod{NamespacedName: k8stypes.NamespacedName{Name: "decode-a", Namespace: "default"}},
+		MetricsState: &backendmetrics.MetricsState{},
+	}
+	decodePodB := &types.PodMetrics{
+		Pod:          &backend.Pod{NamespacedName: k8stypes.NamespacedName{Name: "decode-b", Namespace: "default"}},
+		MetricsState: &backendmetrics.MetricsState{},
+	}
+
+	prefillPods := []types.Pod{prefillPodA, prefillPodB}
+	decodePods := []types.Pod{decodePodA, decodePodB}
+
+	coldPrefixState := &types.CycleState{}
+	coldPrefixState.Write(plugins.StateKey(prefix.PrefixCachePluginType), &prefix.SchedulingContextState{
+		PrefixCacheServers: make(map[prefix.ServerID]int), // empty = cold request
+	})
+
+	ctx := context.Background()
+
+	t.Run("P/D scenario - both profiles tracked separately", func(t *testing.T) {
+		scorer := scorer.NewNoHitLRU(ctx, nil)
+
+		// First cold request with P/D
+		req1 := &types.LLMRequest{RequestId: "pd-request-1"}
+		scorer.Score(ctx, coldPrefixState, req1, append(prefillPods, decodePods...))
+
+		// Simulate scheduling result with both prefill and decode profiles
+		pdResult := &types.SchedulingResult{
+			PrimaryProfileName: "decode",
+			ProfileResults: map[string]*types.ProfileRunResult{
+				"prefill": {
+					TargetPods: []types.Pod{prefillPodA},
+				},
+				"decode": {
+					TargetPods: []types.Pod{decodePodA},
+				},
+			},
+		}
+		scorer.PreRequest(ctx, req1, pdResult)
+
+		// Second cold request - both prefillPodB and decodePodB should score higher
+		// since prefillPodA and decodePodA were just used
+		req2 := &types.LLMRequest{RequestId: "pd-request-2"}
+		prefillScores := scorer.Score(ctx, coldPrefixState, req2, prefillPods)
+		decodeScores := scorer.Score(ctx, coldPrefixState, req2, decodePods)
+
+		if prefillScores[prefillPodB] <= prefillScores[prefillPodA] {
+			t.Errorf("Expected prefill-b to score higher than prefill-a after prefill-a was used: %+v", prefillScores)
+		}
+
+		if decodeScores[decodePodB] <= decodeScores[decodePodA] {
+			t.Errorf("Expected decode-b to score higher than decode-a after decode-a was used: %+v", decodeScores)
+		}
+	})
+
+	t.Run("non-P/D scenario - only primary profile exists", func(t *testing.T) {
+		req := &types.LLMRequest{RequestId: "non-pd-request"}
+		scorer := scorer.NewNoHitLRU(ctx, nil)
+		scorer.Score(ctx, coldPrefixState, req, decodePods)
+
+		// Scheduling result with only decode profile (no prefill)
+		result := &types.SchedulingResult{
+			PrimaryProfileName: "decode",
+			ProfileResults: map[string]*types.ProfileRunResult{
+				"decode": {
+					TargetPods: []types.Pod{decodePodA},
+				},
+				// No "prefill" profile in results
+			},
+		}
+		// Should not panic when prefill profile doesn't exist
+		scorer.PreRequest(ctx, req, result)
+
+		// Verify decodePodA was tracked
+		req2 := &types.LLMRequest{RequestId: "non-pd-request-2"}
+		scores := scorer.Score(ctx, coldPrefixState, req2, decodePods)
+
+		if scores[decodePodB] <= scores[decodePodA] {
+			t.Errorf("Expected decode-b to score higher than decode-a: %+v", scores)
+		}
+	})
+
+	t.Run("nil scheduling result - graceful handling", func(_ *testing.T) {
+		req := &types.LLMRequest{RequestId: "nil-result"}
+		scorer := scorer.NewNoHitLRU(ctx, nil)
+		scorer.Score(ctx, coldPrefixState, req, decodePods)
+
+		// Should not panic with nil result
+		scorer.PreRequest(ctx, req, nil)
+	})
+
+	t.Run("empty profile results - graceful handling", func(_ *testing.T) {
+		req := &types.LLMRequest{RequestId: "empty-results"}
+		scorer := scorer.NewNoHitLRU(ctx, nil)
+		scorer.Score(ctx, coldPrefixState, req, decodePods)
+
+		result := &types.SchedulingResult{
+			PrimaryProfileName: "decode",
+			ProfileResults:     map[string]*types.ProfileRunResult{},
+		}
+		// Should not panic with empty profile results
+		scorer.PreRequest(ctx, req, result)
+	})
+}