diff --git a/.github/workflows/lint.yml b/.github/workflows/lint.yml
index 070815b16..ea040f011 100644
--- a/.github/workflows/lint.yml
+++ b/.github/workflows/lint.yml
@@ -15,7 +15,7 @@ jobs:
           fetch-depth: 0
       - uses: actions/setup-node@v2
         with:
-          node-version: 14
+          node-version: 16
           cache: npm
       - run: npm ci
       - run: |
diff --git a/.github/workflows/release.yml b/.github/workflows/release.yml
index e93ffed06..53d5054a0 100644
--- a/.github/workflows/release.yml
+++ b/.github/workflows/release.yml
@@ -23,7 +23,7 @@ jobs:
           token: ${{ env.GITHUB_TOKEN }}
       - uses: actions/setup-node@v2
         with:
-          node-version: 14
+          node-version: 16
           cache: npm
       - run: npm ci
       - run: npm run lint
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 13fea22eb..707d3d26b 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -20,7 +20,7 @@ jobs:
           fetch-depth: 0
       - uses: actions/setup-node@v2
         with:
-          node-version: 14
+          node-version: 16
           cache: npm
       - run: npm ci
       - run: npm run build:check
@@ -33,7 +33,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        node: [10, 12]
+        node: [10, 12, 14, 18]
     steps:
       - uses: actions/checkout@v2
       - uses: actions/setup-node@v2
@@ -48,7 +48,7 @@ jobs:
     runs-on: windows-latest
     strategy:
       matrix:
-        node: [10, 12, 14]
+        node: [10, 12, 14, 16, 18]
     steps:
       - uses: actions/checkout@v2
       - uses: actions/setup-node@v2
diff --git a/docs/intro/01-installation.md b/docs/intro/01-installation.md
index a9ff25145..429ac1561 100644
--- a/docs/intro/01-installation.md
+++ b/docs/intro/01-installation.md
@@ -5,7 +5,7 @@ Karma runs on [Node.js] and is available as an [npm] package.
 On Mac or Linux we recommend using [NVM](https://github.com/creationix/nvm). On Windows, download Node.js
 from [the official site](https://nodejs.org/) or use the [NVM PowerShell Module](https://www.powershellgallery.com/packages/nvm).
 
-Note: Karma currently works on Node.js **6.x**, **8.x**, and **10.x**. See [FAQ] for more info.
+Karma works on all [LTS releases](https://nodejs.org/en/about/releases/) of Node.js.
 
 ## Installing Karma and plugins
 
diff --git a/docs/intro/04-faq.md b/docs/intro/04-faq.md
index a70444f2c..9387d3caf 100644
--- a/docs/intro/04-faq.md
+++ b/docs/intro/04-faq.md
@@ -27,7 +27,7 @@ The latest stable version from npm (`npm install karma`). See [versioning] for m
 
 
 ### Which version of Node.js does Karma run with?
-Karma works on all active LTS versions of node as specified by the [Node.js Release Working Group](https://github.com/nodejs/Release/blob/master/README.md). The nodejs version numbers are set in the package.json. Older versions of karma work with older versions of nodejs, but are not maintained or updated.
+Karma works on all LTS versions of Node.js as specified by the [Node.js Release Working Group](https://github.com/nodejs/Release/blob/master/README.md). The Node.js version numbers are set in the package.json. Older versions of karma work with older versions of Node.js, but are not maintained or updated.
 
 [mailing list]: https://groups.google.com/d/forum/karma-users
 [karma-ng-scenario]: https://github.com/karma-runner/karma-ng-scenario
diff --git a/lib/middleware/proxy.js b/lib/middleware/proxy.js
index 6b0fcf730..b2e0e7f63 100644
--- a/lib/middleware/proxy.js
+++ b/lib/middleware/proxy.js
@@ -3,6 +3,7 @@ const { Agent: httpAgent } = require('http')
 const { Agent: httpsAgent } = require('https')
 const httpProxy = require('http-proxy')
 const _ = require('lodash')
+const { lookup } = require('../utils/dns-utils')
 
 const log = require('../logger').create('proxy')
 
@@ -41,7 +42,10 @@ function parseProxyConfig (proxies, config) {
     const port = proxyDetails.port || defaultPorts[proxyDetails.protocol] || config.port
     const changeOrigin = proxyConfiguration.changeOrigin || false
     const Agent = protocol === 'https:' ? httpsAgent : httpAgent
-    const agent = new Agent({ keepAlive: true })
+    const agent = new Agent({
+      keepAlive: true,
+      lookup
+    })
     const proxy = httpProxy.createProxyServer({
       target: { host: hostname, port, protocol },
       xfwd: true,
diff --git a/lib/runner.js b/lib/runner.js
index 2e04065b6..fb67ebe92 100644
--- a/lib/runner.js
+++ b/lib/runner.js
@@ -7,6 +7,7 @@ const EventEmitter = require('events').EventEmitter
 const helper = require('./helper')
 const cfg = require('./config')
 const logger = require('./logger')
+const { lookup } = require('./utils/dns-utils')
 const log = logger.create('runner')
 
 function parseExitCode (buffer, defaultExitCode, failOnEmptyTestSuite) {
@@ -74,7 +75,8 @@ function run (cliOptionsOrConfig, done) {
     method: 'POST',
     headers: {
       'Content-Type': 'application/json'
-    }
+    },
+    lookup
   }
 
   const request = http.request(options, function (response) {
diff --git a/lib/stopper.js b/lib/stopper.js
index 964eb5e37..386fa5d83 100644
--- a/lib/stopper.js
+++ b/lib/stopper.js
@@ -2,6 +2,7 @@ const http = require('http')
 const cfg = require('./config')
 const logger = require('./logger')
 const helper = require('./helper')
+const { lookup } = require('./utils/dns-utils')
 
 exports.stop = function (cliOptionsOrConfig, done) {
   cliOptionsOrConfig = cliOptionsOrConfig || {}
@@ -42,7 +43,8 @@ exports.stop = function (cliOptionsOrConfig, done) {
     hostname: config.hostname,
     path: config.urlRoot + 'stop',
     port: config.port,
-    method: 'GET'
+    method: 'GET',
+    lookup
   })
 
   request.on('response', function (response) {
diff --git a/lib/utils/dns-utils.js b/lib/utils/dns-utils.js
new file mode 100644
index 000000000..5d281ed6f
--- /dev/null
+++ b/lib/utils/dns-utils.js
@@ -0,0 +1,11 @@
+const dns = require('dns')
+
+// Node >=17 has different DNS resolution (see
+// https://github.com/nodejs/node/issues/40702), it resolves domains
+// according to the OS settings instead of IPv4-address first. The Karma server
+// only listens on IPv4 address (127.0.0.1) by default, but the requests are
+// sent to `localhost` in several places and `localhost` is resolved into IPv6
+// address (`::`). So the run/stop/proxy request is unable to reach the Karma
+// server and produces an error. To mitigate this issue karma force the
+// IPv4-address first approach in Node >=17 as well.
+module.exports.lookup = (hostname, options, callback) => dns.lookup(hostname, { ...options, verbatim: false }, callback)
diff --git a/test/e2e/support/proxy.js b/test/e2e/support/proxy.js
index 5bf17c1fd..e78a4544c 100644
--- a/test/e2e/support/proxy.js
+++ b/test/e2e/support/proxy.js
@@ -8,7 +8,7 @@ module.exports = class Proxy {
     this.proxyPathRegExp = null
 
     this.proxy = httpProxy.createProxyServer({
-      target: 'http://localhost:9876'
+      target: 'http://127.0.0.1:9876'
     })
 
     this.proxy.on('error', (err) => {