Additional information on "adjusted" variables

[gi4co4]

Thank you for the great DAG tool!

I tried to find some more information about "adjusted" variables. Manual only says the following: "for variables that have been adjusted for in a statistical analysis"

Maybe you could add some more information about the need to mark variables as "adjusted".

For example: when should we mark variables as "adjusted"? Is this option for a case when we do have some prior knowledge that a variable certainly needs to be adjusted in analysis?