Difference between results of installed tbprofiler pipeline and online version

[RehmanZaira]

Hi,
I am analyzing the same data through installed tbprofiler and the online version. I got the Delamanid resistance when using the online version. The version of tbprofier that I am using is 5.0.1.
I am trying to update the tbprofiler but got an error
(env_tbprofiler) ngs@ngs-srv:~$ tb-profiler update_tbdb
[10:43:09] ERROR Traceback (most recent call last): utils.py:391
File
"/home/ngs/miniconda3/envs/env_tbprofiler/bin/t
b-profiler", line 562, in
args.func(args)
File
"/home/ngs/miniconda3/envs/env_tbprofiler/bin/t
b-profiler", line 205, in main_create_db
pp.create_db(args,extra_files=extra_files)
File
"/home/ngs/miniconda3/envs/env_tbprofiler/lib/p
ython3.10/site-packages/pathogenprofiler/db.py"
, line 417, in create_db
hgvs_variants = [r for r in
csv.DictReader(open(args.csv))]
FileNotFoundError: [Errno 2] No such file or
directory: 'tbdb.csv'
Cleaning up after failed run

Traceback (most recent call last):
File "/home/ngs/miniconda3/envs/env_tbprofiler/bin/tb-profiler", line 562, in
args.func(args)
File "/home/ngs/miniconda3/envs/env_tbprofiler/bin/tb-profiler", line 183, in main_update_tbdb
pp.run_cmd(f"tb-profiler create_db --prefix {args.prefix} {tmp} --load")
File "/home/ngs/miniconda3/envs/env_tbprofiler/lib/python3.10/site-packages/pathogenprofiler/utils.py", line 392, in run_cmd
raise ValueError("Command Failed:\n%s\nstderr:\n%s" % (cmd,result.stderr.decode()))
ValueError: Command Failed:
/bin/bash -c set -o pipefail; tb-profiler create_db --prefix tbdb --load
stderr:
Traceback (most recent call last):
File "/home/ngs/miniconda3/envs/env_tbprofiler/bin/tb-profiler", line 562, in
args.func(args)
File "/home/ngs/miniconda3/envs/env_tbprofiler/bin/tb-profiler", line 205, in main_create_db
pp.create_db(args,extra_files=extra_files)
File "/home/ngs/miniconda3/envs/env_tbprofiler/lib/python3.10/site-packages/pathogenprofiler/db.py", line 417, in create_db
hgvs_variants = [r for r in csv.DictReader(open(args.csv))]
FileNotFoundError: [Errno 2] No such file or directory: 'tbdb.csv'
Cleaning up after failed run

Cleaning up after failed run
ERROR tb-profiler:58

                ################################# ERROR                     
                #######################################                     
                                                                            
                This run has failed. Please check all                       
                arguments and make sure all input files                     
                exist. If no solution is found, please open                 
                up an issue at                                              
                https://github.com/jodyphelan/TBProfiler/issu               
                es/new and paste or attach the                              
                contents of the error log (tbdb.errlog.txt)                 
                                                                            
                #############################################               
                ##################################                          

Kindly guide me how to fix that issue.

[RehmanZaira]

Hi Jody,
I am waiting for your response.