diff --git a/cmd/api/handlers/nodes.go b/cmd/api/handlers/nodes.go
index 31ee629e..1854e29e 100644
--- a/cmd/api/handlers/nodes.go
+++ b/cmd/api/handlers/nodes.go
@@ -217,3 +217,37 @@ func (h *HandlersApi) DeleteNodeHandler(w http.ResponseWriter, r *http.Request)
 	log.Debug().Msgf("Returned node %s", n.UUID)
 	utils.HTTPResponse(w, utils.JSONApplicationUTF8, http.StatusOK, types.ApiGenericResponse{Message: "node deleted"})
 }
+
+// LookupNodeHandler - POST Handler to lookup a node by identifier
+func (h *HandlersApi) LookupNodeHandler(w http.ResponseWriter, r *http.Request) {
+	// Debug HTTP if enabled
+	if h.DebugHTTPConfig.Enabled {
+		utils.DebugHTTPDump(h.DebugHTTP, r, h.DebugHTTPConfig.ShowBody)
+	}
+	// Get context data and check access
+	ctx := r.Context().Value(ContextKey(contextAPI)).(ContextValue)
+	if !h.Users.CheckPermissions(ctx[ctxUser], users.AdminLevel, users.NoEnvironment) {
+		apiErrorResponse(w, "no access", http.StatusForbidden, fmt.Errorf("attempt to use API by user %s", ctx[ctxUser]))
+		return
+	}
+	var l types.ApiLookupRequest
+	// Parse request JSON body
+	if err := json.NewDecoder(r.Body).Decode(&l); err != nil {
+		apiErrorResponse(w, "error parsing POST body", http.StatusInternalServerError, err)
+		return
+	}
+	if l.Identifier == "" {
+		apiErrorResponse(w, "error with identifier", http.StatusBadRequest, nil)
+		return
+	}
+	n, err := h.Nodes.GetByIdentifier(l.Identifier)
+	if err != nil {
+		if err.Error() == "record not found" {
+			apiErrorResponse(w, "node not found", http.StatusNotFound, err)
+		} else {
+			apiErrorResponse(w, "error getting node", http.StatusInternalServerError, err)
+		}
+	}
+	// Serialize and serve JSON
+	utils.HTTPResponse(w, utils.JSONApplicationUTF8, http.StatusOK, _nodeToApiLookupResponse(n))
+}
diff --git a/cmd/api/handlers/utils.go b/cmd/api/handlers/utils.go
index 83fffd4d..ff725889 100644
--- a/cmd/api/handlers/utils.go
+++ b/cmd/api/handlers/utils.go
@@ -4,6 +4,7 @@ import (
 	"net/http"
 
 	"github.com/jmpsec/osctrl/pkg/logging"
+	"github.com/jmpsec/osctrl/pkg/nodes"
 	"github.com/jmpsec/osctrl/pkg/types"
 	"github.com/jmpsec/osctrl/pkg/utils"
 	"github.com/rs/zerolog/log"
@@ -53,3 +54,20 @@ func checkValidPlatform(platforms []string, platform string) bool {
 	}
 	return false
 }
+
+// Helper to convert a node into a ApiLookupResponse
+func _nodeToApiLookupResponse(node nodes.OsqueryNode) types.ApiLookupResponse {
+	return types.ApiLookupResponse{
+		UUID:            node.UUID,
+		Platform:        node.Platform,
+		PlatformVersion: node.PlatformVersion,
+		OsqueryVersion:  node.OsqueryVersion,
+		Hostname:        node.Hostname,
+		Localname:       node.Localname,
+		IPAddress:       node.IPAddress,
+		Username:        node.Username,
+		Environment:     node.Environment,
+		HardwareSerial:  node.HardwareSerial,
+		LastSeen:        node.LastSeen.String(),
+	}
+}
diff --git a/cmd/api/main.go b/cmd/api/main.go
index f9a53435..7f30a0de 100644
--- a/cmd/api/main.go
+++ b/cmd/api/main.go
@@ -239,6 +239,9 @@ func osctrlAPIService() {
 	muxAPI.Handle(
 		"POST "+_apiPath(apiNodesPath)+"/{env}/delete",
 		handlerAuthCheck(http.HandlerFunc(handlersApi.DeleteNodeHandler), flagParams.ConfigValues.Auth, flagParams.JWTConfigValues.JWTSecret))
+	muxAPI.Handle(
+		"POST "+_apiPath(apiNodesPath)+"/lookup",
+		handlerAuthCheck(http.HandlerFunc(handlersApi.LookupNodeHandler), flagParams.ConfigValues.Auth, flagParams.JWTConfigValues.JWTSecret))
 	// API: queries by environment
 	muxAPI.Handle(
 		"GET "+_apiPath(apiQueriesPath)+"/{env}",
diff --git a/osctrl-api.yaml b/osctrl-api.yaml
index 8767fd1d..a2e0dcee 100644
--- a/osctrl-api.yaml
+++ b/osctrl-api.yaml
@@ -304,6 +304,52 @@ paths:
       security:
         - Authorization:
             - admin
+  /nodes/lookup:
+    post:
+      tags:
+        - nodes
+      summary: Lookup node by identifier
+      description: Looks up an enrolled node by identifier (UUID, hostname or localname)
+      operationId: LookupNodeHandler
+      requestBody:
+        content:
+          application/json:
+            schema:
+              $ref: "#/components/schemas/ApiLookupRequest"
+      responses:
+        200:
+          description: successful operation
+          content:
+            application/json:
+              schema:
+                $ref: "#/components/schemas/ApiLookupResponse"
+        400:
+          description: bad request
+          content:
+            application/json:
+              schema:
+                $ref: "#/components/schemas/ApiErrorResponse"
+        403:
+          description: no access
+          content:
+            application/json:
+              schema:
+                $ref: "#/components/schemas/ApiErrorResponse"
+        404:
+          description: no nodes
+          content:
+            application/json:
+              schema:
+                $ref: "#/components/schemas/ApiErrorResponse"
+        500:
+          description: error deleting node
+          content:
+            application/json:
+              schema:
+                $ref: "#/components/schemas/ApiErrorResponse"
+      security:
+        - Authorization:
+            - admin
   /queries/{env}:
     get:
       tags:
@@ -2412,6 +2458,41 @@ components:
         TagType:
           type: integer
           format: uint32
+    ApiLookupRequest:
+      type: object
+      properties:
+        Identifier:
+          type: string
+    ApiLookupResponse:
+      type: object
+      properties:
+        ID:
+          type: integer
+          format: int32
+        UUID:
+          type: string
+        Hostname:
+          type: string
+        Localname:
+          type: string
+        IPAddress:
+          type: string
+        Username:
+          type: string
+        HardwareSerial:
+          type: string
+        Platform:
+          type: string
+        PlatformVersion:
+          type: string
+        OsqueryVersion:
+          type: string
+        Environment:
+          type: string
+        EnvironmentUUID:
+          type: string
+        LastSeen:
+          type: string
     MapEnvByID:
       type: object
       properties:
diff --git a/pkg/types/types.go b/pkg/types/types.go
index 25210bb4..1d681aad 100644
--- a/pkg/types/types.go
+++ b/pkg/types/types.go
@@ -109,3 +109,25 @@ type ApiTagsRequest struct {
 	EnvUUID     string `json:"env_uuid"`
 	TagType     uint   `json:"tagtype"`
 }
+
+// ApiLookupRequest to receive lookup requests
+type ApiLookupRequest struct {
+	Identifier string `json:"identifier"`
+}
+
+// ApiLookupResponse to be returned to API lookup requests
+type ApiLookupResponse struct {
+	ID              uint   `json:"id"`
+	UUID            string `json:"uuid"`
+	Hostname        string `json:"hostname"`
+	Localname       string `json:"localname"`
+	IPAddress       string `json:"ip_address"`
+	Username        string `json:"username"`
+	HardwareSerial  string `json:"hardware_serial"`
+	Platform        string `json:"platform"`
+	PlatformVersion string `json:"platform_version"`
+	OsqueryVersion  string `json:"osquery_version"`
+	Environment     string `json:"environment"`
+	EnvironmentUUID string `json:"environment_uuid"`
+	LastSeen        string `json:"last_seen"`
+}