diff --git a/docs/cli/edit.md b/docs/cli/edit.md
index fcb4a42d0a..07a4f2e829 100644
--- a/docs/cli/edit.md
+++ b/docs/cli/edit.md
@@ -1,7 +1,7 @@
 <!-- @generated by usage-cli from usage spec -->
 # `mise edit`
 
-- **Usage**: `mise edit [-n --dry-run] [-t --tool-versions <TOOL_VERSIONS>] [PATH]`
+- **Usage**: `mise edit [FLAGS] [PATH]`
 - **Source code**: [`src/cli/edit.rs`](https://github.com/jdx/mise/blob/main/src/cli/edit.rs)
 
 Edit mise.toml interactively
@@ -14,6 +14,10 @@ Path to the config file to create
 
 ## Flags
 
+### `-g --global`
+
+Edit the global config file (~/.config/mise/config.toml)
+
 ### `-n --dry-run`
 
 Show what would be generated without writing to file
@@ -27,6 +31,7 @@ Examples:
 ```
 mise edit             # edit mise.toml interactively
 mise edit .mise.toml  # edit a specific file
+mise edit -g          # edit the global config file
 mise edit -y          # skip interactive editor
 mise edit -n          # preview without writing
 ```
diff --git a/docs/cli/generate.md b/docs/cli/generate.md
index 821fe8235a..5e223e1114 100644
--- a/docs/cli/generate.md
+++ b/docs/cli/generate.md
@@ -10,7 +10,7 @@ Generate files for various tools/services
 ## Subcommands
 
 - [`mise generate bootstrap [FLAGS]`](/cli/generate/bootstrap.md)
-- [`mise generate config [-n --dry-run] [-t --tool-versions <TOOL_VERSIONS>] [PATH]`](/cli/generate/config.md)
+- [`mise generate config [FLAGS] [PATH]`](/cli/generate/config.md)
 - [`mise generate devcontainer [FLAGS]`](/cli/generate/devcontainer.md)
 - [`mise generate git-pre-commit [FLAGS]`](/cli/generate/git-pre-commit.md)
 - [`mise generate github-action [FLAGS]`](/cli/generate/github-action.md)
diff --git a/docs/cli/generate/config.md b/docs/cli/generate/config.md
index 2130aa5ddc..9799226f0e 100644
--- a/docs/cli/generate/config.md
+++ b/docs/cli/generate/config.md
@@ -1,7 +1,7 @@
 <!-- @generated by usage-cli from usage spec -->
 # `mise generate config`
 
-- **Usage**: `mise generate config [-n --dry-run] [-t --tool-versions <TOOL_VERSIONS>] [PATH]`
+- **Usage**: `mise generate config [FLAGS] [PATH]`
 - **Source code**: [`src/cli/generate/config.rs`](https://github.com/jdx/mise/blob/main/src/cli/generate/config.rs)
 
 Generate a mise.toml file
@@ -14,6 +14,10 @@ Path to the config file to create
 
 ## Flags
 
+### `-g --global`
+
+Generate the global config file (~/.config/mise/config.toml)
+
 ### `-n --dry-run`
 
 Show what would be generated without writing to file
@@ -25,8 +29,9 @@ Path to a .tool-versions file to import tools from
 Examples:
 
 ```
-mise edit             # edit mise.toml interactively
-mise edit .mise.toml  # edit a specific file
-mise edit -y          # skip interactive editor
-mise edit -n          # preview without writing
+mise generate config             # generate mise.toml interactively
+mise generate config .mise.toml  # generate a specific file
+mise generate config -g          # generate the global config file
+mise generate config -y          # skip interactive editor
+mise generate config -n          # preview without writing
 ```
diff --git a/docs/cli/index.md b/docs/cli/index.md
index cd78522758..06ee921e14 100644
--- a/docs/cli/index.md
+++ b/docs/cli/index.md
@@ -106,7 +106,7 @@ Can also use `MISE_NO_HOOKS=1`
 - [`mise fmt [FLAGS]`](/cli/fmt.md)
 - [`mise generate <SUBCOMMAND>`](/cli/generate.md)
 - [`mise generate bootstrap [FLAGS]`](/cli/generate/bootstrap.md)
-- [`mise generate config [-n --dry-run] [-t --tool-versions <TOOL_VERSIONS>] [PATH]`](/cli/generate/config.md)
+- [`mise generate config [FLAGS] [PATH]`](/cli/generate/config.md)
 - [`mise generate devcontainer [FLAGS]`](/cli/generate/devcontainer.md)
 - [`mise generate git-pre-commit [FLAGS]`](/cli/generate/git-pre-commit.md)
 - [`mise generate github-action [FLAGS]`](/cli/generate/github-action.md)
@@ -114,7 +114,7 @@ Can also use `MISE_NO_HOOKS=1`
 - [`mise generate task-stubs [-d --dir <DIR>] [-m --mise-bin <MISE_BIN>]`](/cli/generate/task-stubs.md)
 - [`mise generate tool-stub [FLAGS] <OUTPUT>`](/cli/generate/tool-stub.md)
 - [`mise implode [-n --dry-run] [--config]`](/cli/implode.md)
-- [`mise edit [-n --dry-run] [-t --tool-versions <TOOL_VERSIONS>] [PATH]`](/cli/edit.md)
+- [`mise edit [FLAGS] [PATH]`](/cli/edit.md)
 - [`mise install [FLAGS] [TOOL@VERSION]…`](/cli/install.md)
 - [`mise install-into <TOOL@VERSION> <PATH>`](/cli/install-into.md)
 - [`mise latest [-i --installed] [--before <BEFORE>] <TOOL@VERSION>`](/cli/latest.md)
diff --git a/e2e/cli/test_edit_global b/e2e/cli/test_edit_global
new file mode 100644
index 0000000000..247c73b59e
--- /dev/null
+++ b/e2e/cli/test_edit_global
@@ -0,0 +1,29 @@
+#!/usr/bin/env bash
+
+# `mise edit --global` writes to the global config file path.
+
+export MISE_GLOBAL_CONFIG_FILE="$PWD/global-config.toml"
+
+assert_contains "mise edit --global --dry-run 2>&1" "global-config.toml"
+assert_contains "mise edit -g -n 2>&1" "global-config.toml"
+
+# A positional path overrides --global regardless of argument order.
+assert_contains "mise edit --global custom.toml --dry-run 2>&1" "custom.toml"
+assert_not_contains "mise edit --global custom.toml --dry-run 2>&1" "global-config.toml"
+assert_contains "mise edit custom.toml --global --dry-run 2>&1" "custom.toml"
+assert_not_contains "mise edit custom.toml --global --dry-run 2>&1" "global-config.toml"
+
+# Without --global, the default config filename is used (regression guard).
+assert_contains "mise edit --dry-run 2>&1" "mise.toml"
+assert_not_contains "mise edit --dry-run 2>&1" "global-config.toml"
+
+# --tool-versions merges into the resolved target file, not the local mise.toml.
+cat >preexisting.toml <<EOF
+[tools]
+go = "1.22"
+EOF
+cat >.tool-versions <<EOF
+node 22
+EOF
+assert_contains "mise edit preexisting.toml --tool-versions .tool-versions --dry-run 2>&1" 'go = "1.22"'
+assert_contains "mise edit preexisting.toml --tool-versions .tool-versions --dry-run 2>&1" 'node = "22"'
diff --git a/man/man1/mise.1 b/man/man1/mise.1
index 43ff59701c..a7c297cdfc 100644
--- a/man/man1/mise.1
+++ b/man/man1/mise.1
@@ -1039,6 +1039,9 @@ Generate a mise.toml file
 \fBOptions:\fR
 .PP
 .TP
+\fB\-g, \-\-global\fR
+Generate the global config file (~/.config/mise/config.toml)
+.TP
 \fB\-n, \-\-dry\-run\fR
 Show what would be generated without writing to file
 .TP
@@ -1281,6 +1284,9 @@ Edit mise.toml interactively
 \fBOptions:\fR
 .PP
 .TP
+\fB\-g, \-\-global\fR
+Edit the global config file (~/.config/mise/config.toml)
+.TP
 \fB\-n, \-\-dry\-run\fR
 Show what would be generated without writing to file
 .TP
diff --git a/mise.usage.kdl b/mise.usage.kdl
index dd74da1901..6cb526f8e6 100644
--- a/mise.usage.kdl
+++ b/mise.usage.kdl
@@ -321,7 +321,8 @@ cmd generate subcommand_required=#true help="Generate files for various tools/se
         }
     }
     cmd config help="Generate a mise.toml file" {
-        after_long_help "Examples:\n\n    $ mise edit             # edit mise.toml interactively\n    $ mise edit .mise.toml  # edit a specific file\n    $ mise edit -y          # skip interactive editor\n    $ mise edit -n          # preview without writing\n"
+        after_long_help "Examples:\n\n    $ mise generate config             # generate mise.toml interactively\n    $ mise generate config .mise.toml  # generate a specific file\n    $ mise generate config -g          # generate the global config file\n    $ mise generate config -y          # skip interactive editor\n    $ mise generate config -n          # preview without writing\n"
+        flag "-g --global" help="Generate the global config file (~/.config/mise/config.toml)"
         flag "-n --dry-run" help="Show what would be generated without writing to file"
         flag "-t --tool-versions" help="Path to a .tool-versions file to import tools from" {
             arg <TOOL_VERSIONS>
@@ -482,7 +483,8 @@ cmd implode help="Removes mise CLI and all related data" {
     flag --config help="Also remove config directory"
 }
 cmd edit help="Edit mise.toml interactively" {
-    after_long_help "Examples:\n\n    $ mise edit             # edit mise.toml interactively\n    $ mise edit .mise.toml  # edit a specific file\n    $ mise edit -y          # skip interactive editor\n    $ mise edit -n          # preview without writing\n"
+    after_long_help "Examples:\n\n    $ mise edit             # edit mise.toml interactively\n    $ mise edit .mise.toml  # edit a specific file\n    $ mise edit -g          # edit the global config file\n    $ mise edit -y          # skip interactive editor\n    $ mise edit -n          # preview without writing\n"
+    flag "-g --global" help="Edit the global config file (~/.config/mise/config.toml)"
     flag "-n --dry-run" help="Show what would be generated without writing to file"
     flag "-t --tool-versions" help="Path to a .tool-versions file to import tools from" {
         arg <TOOL_VERSIONS>
diff --git a/src/cli/edit.rs b/src/cli/edit.rs
index 836d39b446..0fdef2c82e 100644
--- a/src/cli/edit.rs
+++ b/src/cli/edit.rs
@@ -16,7 +16,7 @@ use crate::backend::backend_type::BackendType;
 use crate::cli::args::BackendArg;
 use crate::cli::version::VERSION_PLAIN;
 use crate::config::config_file;
-use crate::config::{Config, Settings};
+use crate::config::{Config, Settings, global_config_path};
 use crate::file::display_path;
 use crate::plugins::PluginType;
 use crate::registry::REGISTRY;
@@ -122,6 +122,9 @@ impl BackendProvider for MiseBackendProvider {
 #[derive(Debug, clap::Args)]
 #[clap(verbatim_doc_comment, after_long_help = AFTER_LONG_HELP)]
 pub struct Edit {
+    /// Edit the global config file (~/.config/mise/config.toml)
+    #[clap(long, short = 'g')]
+    global: bool,
     /// Show what would be generated without writing to file
     #[clap(long, short = 'n')]
     dry_run: bool,
@@ -143,15 +146,32 @@ struct DetectedTool {
 }
 
 impl Edit {
+    pub(crate) fn new(
+        global: bool,
+        dry_run: bool,
+        path: Option<PathBuf>,
+        tool_versions: Option<PathBuf>,
+    ) -> Self {
+        Self {
+            global,
+            dry_run,
+            path,
+            tool_versions,
+        }
+    }
+
     pub async fn run(self) -> Result<()> {
-        let path = self
-            .path
-            .clone()
-            .unwrap_or_else(|| PathBuf::from(&*env::MISE_DEFAULT_CONFIG_FILENAME));
+        let path = if let Some(path) = self.path.clone() {
+            path
+        } else if self.global {
+            global_config_path()
+        } else {
+            PathBuf::from(&*env::MISE_DEFAULT_CONFIG_FILENAME)
+        };
 
         if let Some(tool_versions) = &self.tool_versions {
             // Import from .tool-versions file
-            let doc = self.tool_versions(tool_versions).await?;
+            let doc = self.tool_versions(tool_versions, &path).await?;
 
             if self.dry_run {
                 info!("would write to {}", display_path(&path));
@@ -250,9 +270,8 @@ impl Edit {
         Ok(())
     }
 
-    async fn tool_versions(&self, tool_versions: &Path) -> Result<String> {
-        let to =
-            config_file::parse_or_init(&PathBuf::from(&*env::MISE_DEFAULT_CONFIG_FILENAME)).await?;
+    async fn tool_versions(&self, tool_versions: &Path, path: &Path) -> Result<String> {
+        let to = config_file::parse_or_init(path).await?;
         let from = config_file::parse(tool_versions).await?;
         let tools = from.to_tool_request_set()?.tools;
         for (ba, tools) in tools {
@@ -364,11 +383,12 @@ fn extract_version(tool: &str, path: &Path) -> Option<String> {
     }
 }
 
-pub static AFTER_LONG_HELP: &str = color_print::cstr!(
+static AFTER_LONG_HELP: &str = color_print::cstr!(
     r#"<bold><underline>Examples:</underline></bold>
 
     $ <bold>mise edit</bold>             <dim># edit mise.toml interactively</dim>
     $ <bold>mise edit .mise.toml</bold>  <dim># edit a specific file</dim>
+    $ <bold>mise edit -g</bold>          <dim># edit the global config file</dim>
     $ <bold>mise edit -y</bold>          <dim># skip interactive editor</dim>
     $ <bold>mise edit -n</bold>          <dim># preview without writing</dim>
 "#
diff --git a/src/cli/generate/config.rs b/src/cli/generate/config.rs
index ad7c652f58..19a714b814 100644
--- a/src/cli/generate/config.rs
+++ b/src/cli/generate/config.rs
@@ -1,16 +1,43 @@
+use std::path::PathBuf;
+
+use clap::ValueHint;
+
 use crate::Result;
-use crate::cli::edit;
+use crate::cli::edit::Edit;
 
 /// Generate a mise.toml file
 #[derive(Debug, clap::Args)]
-#[clap(verbatim_doc_comment, after_long_help = edit::AFTER_LONG_HELP)]
+#[clap(verbatim_doc_comment, after_long_help = AFTER_LONG_HELP)]
 pub struct Config {
-    #[clap(flatten)]
-    edit: edit::Edit,
+    /// Generate the global config file (~/.config/mise/config.toml)
+    #[clap(long, short = 'g')]
+    global: bool,
+    /// Show what would be generated without writing to file
+    #[clap(long, short = 'n')]
+    dry_run: bool,
+    /// Path to the config file to create
+    #[clap(verbatim_doc_comment, value_hint = ValueHint::FilePath)]
+    path: Option<PathBuf>,
+    /// Path to a .tool-versions file to import tools from
+    #[clap(long, short, verbatim_doc_comment, value_hint = ValueHint::FilePath)]
+    tool_versions: Option<PathBuf>,
 }
 
 impl Config {
     pub async fn run(self) -> Result<()> {
-        self.edit.run().await
+        Edit::new(self.global, self.dry_run, self.path, self.tool_versions)
+            .run()
+            .await
     }
 }
+
+static AFTER_LONG_HELP: &str = color_print::cstr!(
+    r#"<bold><underline>Examples:</underline></bold>
+
+    $ <bold>mise generate config</bold>             <dim># generate mise.toml interactively</dim>
+    $ <bold>mise generate config .mise.toml</bold>  <dim># generate a specific file</dim>
+    $ <bold>mise generate config -g</bold>          <dim># generate the global config file</dim>
+    $ <bold>mise generate config -y</bold>          <dim># skip interactive editor</dim>
+    $ <bold>mise generate config -n</bold>          <dim># preview without writing</dim>
+"#
+);
diff --git a/xtasks/fig/src/mise.ts b/xtasks/fig/src/mise.ts
index 8ea529e863..0e82ffb3bd 100644
--- a/xtasks/fig/src/mise.ts
+++ b/xtasks/fig/src/mise.ts
@@ -1155,6 +1155,12 @@ const completionSpec: Fig.Spec = {
           name: "config",
           description: "Generate a mise.toml file",
           options: [
+            {
+              name: ["-g", "--global"],
+              description:
+                "Generate the global config file (~/.config/mise/config.toml)",
+              isRepeatable: false,
+            },
             {
               name: ["-n", "--dry-run"],
               description:
@@ -1455,6 +1461,12 @@ const completionSpec: Fig.Spec = {
       name: "edit",
       description: "Edit mise.toml interactively",
       options: [
+        {
+          name: ["-g", "--global"],
+          description:
+            "Edit the global config file (~/.config/mise/config.toml)",
+          isRepeatable: false,
+        },
         {
           name: ["-n", "--dry-run"],
           description: "Show what would be generated without writing to file",