diff --git a/prow/cluster/jobs/istio/istio/istio.istio.master.gen.yaml b/prow/cluster/jobs/istio/istio/istio.istio.master.gen.yaml
index f9c6c3d2709..b94a6100bda 100644
--- a/prow/cluster/jobs/istio/istio/istio.istio.master.gen.yaml
+++ b/prow/cluster/jobs/istio/istio/istio.istio.master.gen.yaml
@@ -65,6 +65,136 @@ periodics:
       name: cgroup
     - emptyDir: {}
       name: docker-root
+- annotations:
+    testgrid-alert-email: istio-oncall@googlegroups.com
+    testgrid-dashboards: istio_istio_periodic
+    testgrid-num-failures-to-alert: "1"
+  decorate: true
+  extra_refs:
+  - base_ref: master
+    org: istio
+    path_alias: istio.io/istio
+    repo: istio
+  interval: 10m
+  name: integ-multicluster-k8s-tests-n2_istio_periodic
+  spec:
+    containers:
+    - command:
+      - entrypoint
+      - prow/integ-suite-kind.sh
+      - --topology
+      - MULTICLUSTER
+      - test.integration.multicluster.kube.presubmit
+      env:
+      - name: TEST_SELECT
+        value: -postsubmit,-flaky,+multicluster
+      image: gcr.io/istio-testing/build-tools:master-2021-05-07T04-05-01
+      name: ""
+      resources:
+        limits:
+          memory: 24Gi
+        requests:
+          cpu: "5"
+          memory: 3Gi
+      securityContext:
+        privileged: true
+      volumeMounts:
+      - mountPath: /home/prow/go/pkg
+        name: build-cache
+        subPath: gomod
+      - mountPath: /lib/modules
+        name: modules
+        readOnly: true
+      - mountPath: /sys/fs/cgroup
+        name: cgroup
+        readOnly: true
+      - mountPath: /var/lib/docker
+        name: docker-root
+      - mountPath: /gocache
+        name: build-cache
+        subPath: gocache
+    nodeSelector:
+      testing: test-pool-n2
+    volumes:
+    - hostPath:
+        path: /tmp/prow/cache
+        type: DirectoryOrCreate
+      name: build-cache
+    - hostPath:
+        path: /lib/modules
+        type: Directory
+      name: modules
+    - hostPath:
+        path: /sys/fs/cgroup
+        type: Directory
+      name: cgroup
+    - emptyDir: {}
+      name: docker-root
+- annotations:
+    testgrid-alert-email: istio-oncall@googlegroups.com
+    testgrid-dashboards: istio_istio_periodic
+    testgrid-num-failures-to-alert: "1"
+  decorate: true
+  extra_refs:
+  - base_ref: master
+    org: istio
+    path_alias: istio.io/istio
+    repo: istio
+  interval: 10m
+  name: integ-multicluster-k8s-tests-e2_istio_periodic
+  spec:
+    containers:
+    - command:
+      - entrypoint
+      - prow/integ-suite-kind.sh
+      - --topology
+      - MULTICLUSTER
+      - test.integration.multicluster.kube.presubmit
+      env:
+      - name: TEST_SELECT
+        value: -postsubmit,-flaky,+multicluster
+      image: gcr.io/istio-testing/build-tools:master-2021-05-07T04-05-01
+      name: ""
+      resources:
+        limits:
+          memory: 24Gi
+        requests:
+          cpu: "5"
+          memory: 3Gi
+      securityContext:
+        privileged: true
+      volumeMounts:
+      - mountPath: /home/prow/go/pkg
+        name: build-cache
+        subPath: gomod
+      - mountPath: /lib/modules
+        name: modules
+        readOnly: true
+      - mountPath: /sys/fs/cgroup
+        name: cgroup
+        readOnly: true
+      - mountPath: /var/lib/docker
+        name: docker-root
+      - mountPath: /gocache
+        name: build-cache
+        subPath: gocache
+    nodeSelector:
+      testing: test-pool-e2
+    volumes:
+    - hostPath:
+        path: /tmp/prow/cache
+        type: DirectoryOrCreate
+      name: build-cache
+    - hostPath:
+        path: /lib/modules
+        type: Directory
+      name: modules
+    - hostPath:
+        path: /sys/fs/cgroup
+        type: Directory
+      name: cgroup
+    - emptyDir: {}
+      name: docker-root
 postsubmits:
   istio/istio:
   - annotations:
diff --git a/prow/config/jobs/istio.yaml b/prow/config/jobs/istio.yaml
index 784d3fadf2d..e82c9e73d8c 100644
--- a/prow/config/jobs/istio.yaml
+++ b/prow/config/jobs/istio.yaml
@@ -129,6 +129,42 @@ jobs:
       - name: TEST_SELECT
         value: "-postsubmit,-flaky,+multicluster"
 
+  # To test for https://github.com/istio/istio/issues/32985
+  # Runs on an isolated node pool with n2 instances
+  - name: integ-multicluster-k8s-tests-n2
+    types: [periodic]
+    node_selector:
+      testing: test-pool-n2
+    interval: 10m
+    command:
+      - entrypoint
+      - prow/integ-suite-kind.sh
+      - --topology
+      - MULTICLUSTER
+      - test.integration.multicluster.kube.presubmit
+    requirements: [kind]
+    env:
+      - name: TEST_SELECT
+        value: "-postsubmit,-flaky,+multicluster"
+
+  # To test for https://github.com/istio/istio/issues/32985
+  # Runs on an isolated node pool with e2 instances
+  - name: integ-multicluster-k8s-tests-e2
+    types: [periodic]
+    node_selector:
+      testing: test-pool-e2
+    interval: 10m
+    command:
+      - entrypoint
+      - prow/integ-suite-kind.sh
+      - --topology
+      - MULTICLUSTER
+      - test.integration.multicluster.kube.presubmit
+    requirements: [kind]
+    env:
+      - name: TEST_SELECT
+        value: "-postsubmit,-flaky,+multicluster"
+
   - name: integ-distroless-k8s-tests
     command: [entrypoint, prow/integ-suite-kind.sh, test.integration.kube.reachability]
     requirements: [kind]