diff --git a/.github/workflows/nightly-backward-compatibility.yml b/.github/workflows/nightly-backward-compatibility.yml
new file mode 100644
index 00000000000..0423f9b90b3
--- /dev/null
+++ b/.github/workflows/nightly-backward-compatibility.yml
@@ -0,0 +1,92 @@
+name: Nightly backward compatibility
+
+on:
+  schedule:
+    - cron: "0 2 * * *"
+    - cron: "0 14 * * *"
+  workflow_dispatch:
+    inputs:
+      total-releases:
+        description: "Total number of releases to test"
+        required: true
+        type: number
+        default: 3
+      cardano-node-version:
+        description: "Cardano node version used in e2e"
+        required: true
+        type: string
+        default: "9.2.1"
+
+jobs:
+  prepare-binaries:
+    runs-on: ubuntu-22.04
+    outputs:
+      tags: ${{ steps.tags-test-lab.outputs.tags }}
+    steps:
+      - name: Checkout
+        uses: actions/checkout@v4
+
+      - name: Download releases artifacts binaries
+        run: |
+          ./.github/workflows/scripts/download-distribution-binaries.sh ${{ inputs.total-releases }
+
+      - name: Build e2e
+        run: |
+          cargo build --release --bin mithril-end-to-end
+          cp ./target/release/mithril-end-to-end ./mithril-binaries/unstable
+
+      - name: Upload Mithril binaries
+        uses: actions/upload-artifact@v4
+        with:
+          name: mithril-binaries
+          path: ./mithril-binaries
+
+      - name: Prepare test lab tags
+        id: tags-test-lab
+        run: |
+          TAGS=$(cat ./mithril-binaries/tags.json)
+          echo "Test Lab Tags: $TAGS"
+          echo "tags=$TAGS" >> $GITHUB_OUTPUT
+
+  e2e:
+    runs-on: ubuntu-22.04
+    needs: [prepare-binaries]
+    strategy:
+      fail-fast: false
+      matrix:
+        tag: ${{ fromJSON(needs.prepare-binaries.outputs.tags) }}
+        node:
+          [mithril-aggregator, mithril-client, mithril-signer, mithril-relay]
+        cardano_node_version: ${{ inputs.cardano-node-version }}
+        run_id: ["#1"]
+
+    steps:
+      - name: Checkout
+        uses: actions/checkout@v4
+
+      - name: Download binaries
+        uses: actions/download-artifact@v4
+        with:
+          name: mithril-binaries
+          path: ./mithril-binaries
+
+      - name: Prepare binaries
+        run: |
+          mkdir -p mithril-binaries/e2e
+          cp ./mithril-binaries/unstable/* ./mithril-binaries/e2e
+          cp --remove-destination ./mithril-binaries/${{ matrix.tag }}/${{ matrix.node }} ./mithril-binaries/e2e/
+
+          chmod +x ./mithril-binaries/e2e/mithril-aggregator
+          chmod +x ./mithril-binaries/e2e/mithril-client
+          chmod +x ./mithril-binaries/e2e/mithril-signer
+          chmod +x ./mithril-binaries/e2e/mithril-relay
+          chmod +x ./mithril-binaries/e2e/mithril-end-to-end
+          mkdir artifacts
+
+      - name: Run E2E tests
+        run: |
+          ./mithril-binaries/e2e/mithril-end-to-end -vvv \\
+                --bin-directory ./mithril-binaries/e2e \\
+                --work-directory=./artifacts \\
+                --devnet-scripts-directory=./mithril-test-lab/mithril-devnet \\
+                --cardano-node-version ${{ matrix.cardano_node_version }}
diff --git a/.github/workflows/scripts/download-distribution-binaries.sh b/.github/workflows/scripts/download-distribution-binaries.sh
new file mode 100755
index 00000000000..348c528c236
--- /dev/null
+++ b/.github/workflows/scripts/download-distribution-binaries.sh
@@ -0,0 +1,22 @@
+#! /bin/bash
+
+set -e
+
+TOTAL_RELEASES=$1
+ASSETS_DIRECTORY="./mithril-binaries"
+TAG_FILE=$ASSETS_DIRECTORY/tags.json
+
+echo ">> Retrieving artifacts for last ${TOTAL_RELEASES} releases and unstable"
+mkdir -p $ASSETS_DIRECTORY
+gh api /repos/input-output-hk/mithril/releases | jq -r --argjson TOTAL $TOTAL_RELEASES '[.[] | select(.prerelease == false)] | [.[:$TOTAL][].tag_name]' >> $TAG_FILE
+
+TAG_NAMES=$(cat $TAG_FILE | jq -r '.[]' | tr '\n' ' ')
+for TAG_NAME in unstable $TAG_NAMES
+do
+    echo ">>>> Retrieving artifacts for release ${TAG_NAME}"
+    ARCHIVE_DIRECTORY="./mithril-binaries/$TAG_NAME"
+    mkdir -p $ARCHIVE_DIRECTORY
+    gh release download --repo input-output-hk/mithril $TAG_NAME -O mithril-archive --pattern "mithril-$TAG_NAME*-linux-x64.tar.gz"
+    tar xzf mithril-archive -C $ARCHIVE_DIRECTORY mithril-aggregator mithril-signer mithril-client mithril-relay
+    rm mithril-archive
+done