diff --git a/homeassistant/components/deconz/gateway.py b/homeassistant/components/deconz/gateway.py
index a982d110f1feee..a9286cca112b8a 100644
--- a/homeassistant/components/deconz/gateway.py
+++ b/homeassistant/components/deconz/gateway.py
@@ -301,7 +301,10 @@ async def options_updated(self) -> None:
 
         entity_registry = er.async_get(self.hass)
 
-        for entity_id, deconz_id in self.deconz_ids.items():
+        # Copy the ids since calling async_remove will modify the dict
+        # and will cause a runtime error because the dict size changes
+        # during iteration
+        for entity_id, deconz_id in self.deconz_ids.copy().items():
             if deconz_id in deconz_ids and entity_registry.async_is_registered(
                 entity_id
             ):