diff --git a/panel/tests/widgets/test_tables.py b/panel/tests/widgets/test_tables.py
index 26ca7dbf29..a3d904d64f 100644
--- a/panel/tests/widgets/test_tables.py
+++ b/panel/tests/widgets/test_tables.py
@@ -2284,3 +2284,15 @@ def test_bokeh_formatter_column_with_no_textalign_but_text_align_set(document, c
 
     model = table.get_root(document, comm)
     assert model.configuration['columns'][1]['hozAlign'] == 'center'
+
+
+def test_selection_cleared_remote_pagination_new_values(document, comm):
+    df = pd.DataFrame(range(200))
+    table = Tabulator(df, page_size=50, pagination="remote", selectable="checkbox")
+    table.selection = [1, 2, 3]
+
+    table.value = df
+    assert table.selection == [1, 2, 3]
+
+    table.value = df.copy()
+    assert table.selection == []
diff --git a/panel/widgets/tables.py b/panel/widgets/tables.py
index c71ddae130..c1899ccb02 100644
--- a/panel/widgets/tables.py
+++ b/panel/widgets/tables.py
@@ -1191,6 +1191,7 @@ def __init__(self, value=None, **params):
         super().__init__(value=value, **params)
         self._configuration = configuration
         self.param.watch(self._update_children, self._content_params)
+        self.param.watch(self._clear_selection_remote_pagination, 'value')
         if click_handler:
             self.on_click(click_handler)
         if edit_handler:
@@ -1596,6 +1597,10 @@ def _update_max_page(self):
         for ref, (model, _) in self._models.items():
             self._apply_update([], {'max_page': max_page}, model, ref)
 
+    def _clear_selection_remote_pagination(self, event):
+        if event.new is not event.old and self.pagination == 'remote':
+            self.selection = []
+
     def _update_selected(self, *events: param.parameterized.Event, indices=None):
         kwargs = {}
         if self.pagination == 'remote' and self.value is not None: