diff --git a/api/envoy/extensions/filters/http/response_map/v3/response_map.proto b/api/envoy/extensions/filters/http/response_map/v3/response_map.proto
index b60eb5e85d843..4f24250f363b2 100644
--- a/api/envoy/extensions/filters/http/response_map/v3/response_map.proto
+++ b/api/envoy/extensions/filters/http/response_map/v3/response_map.proto
@@ -81,3 +81,14 @@ message ResponseMap {
   //
   config.core.v3.SubstitutionFormatString body_format = 2;
 }
+
+// Extra settings on a per virtualhost/route/weighted-cluster level.
+message ResponseMapPerRoute {
+  oneof override {
+    option (validate.required) = true;
+
+    // Disable the response map filter for this particular vhost or route.
+    // If disabled is specified in multiple per-filter-configs, the most specific one will be used.
+    bool disabled = 1 [(validate.rules).bool = {const: true}];
+  }
+}
diff --git a/api/envoy/extensions/filters/http/response_map/v4alpha/response_map.proto b/api/envoy/extensions/filters/http/response_map/v4alpha/response_map.proto
index 827bf0481be08..4e005f6904ccc 100644
--- a/api/envoy/extensions/filters/http/response_map/v4alpha/response_map.proto
+++ b/api/envoy/extensions/filters/http/response_map/v4alpha/response_map.proto
@@ -87,3 +87,17 @@ message ResponseMap {
   //
   config.core.v4alpha.SubstitutionFormatString body_format = 2;
 }
+
+// Extra settings on a per virtualhost/route/weighted-cluster level.
+message ResponseMapPerRoute {
+  option (udpa.annotations.versioning).previous_message_type =
+      "envoy.extensions.filters.http.response_map.v3.ResponseMapPerRoute";
+
+  oneof override {
+    option (validate.required) = true;
+
+    // Disable the response map filter for this particular vhost or route.
+    // If disabled is specified in multiple per-filter-configs, the most specific one will be used.
+    bool disabled = 1 [(validate.rules).bool = {const: true}];
+  }
+}
diff --git a/generated_api_shadow/envoy/extensions/filters/http/response_map/v3/response_map.proto b/generated_api_shadow/envoy/extensions/filters/http/response_map/v3/response_map.proto
index b60eb5e85d843..4f24250f363b2 100644
--- a/generated_api_shadow/envoy/extensions/filters/http/response_map/v3/response_map.proto
+++ b/generated_api_shadow/envoy/extensions/filters/http/response_map/v3/response_map.proto
@@ -81,3 +81,14 @@ message ResponseMap {
   //
   config.core.v3.SubstitutionFormatString body_format = 2;
 }
+
+// Extra settings on a per virtualhost/route/weighted-cluster level.
+message ResponseMapPerRoute {
+  oneof override {
+    option (validate.required) = true;
+
+    // Disable the response map filter for this particular vhost or route.
+    // If disabled is specified in multiple per-filter-configs, the most specific one will be used.
+    bool disabled = 1 [(validate.rules).bool = {const: true}];
+  }
+}
diff --git a/generated_api_shadow/envoy/extensions/filters/http/response_map/v4alpha/response_map.proto b/generated_api_shadow/envoy/extensions/filters/http/response_map/v4alpha/response_map.proto
index 827bf0481be08..4e005f6904ccc 100644
--- a/generated_api_shadow/envoy/extensions/filters/http/response_map/v4alpha/response_map.proto
+++ b/generated_api_shadow/envoy/extensions/filters/http/response_map/v4alpha/response_map.proto
@@ -87,3 +87,17 @@ message ResponseMap {
   //
   config.core.v4alpha.SubstitutionFormatString body_format = 2;
 }
+
+// Extra settings on a per virtualhost/route/weighted-cluster level.
+message ResponseMapPerRoute {
+  option (udpa.annotations.versioning).previous_message_type =
+      "envoy.extensions.filters.http.response_map.v3.ResponseMapPerRoute";
+
+  oneof override {
+    option (validate.required) = true;
+
+    // Disable the response map filter for this particular vhost or route.
+    // If disabled is specified in multiple per-filter-configs, the most specific one will be used.
+    bool disabled = 1 [(validate.rules).bool = {const: true}];
+  }
+}
diff --git a/source/extensions/filters/http/response_map/BUILD b/source/extensions/filters/http/response_map/BUILD
index e6d4e8769276b..040c4c1e54060 100644
--- a/source/extensions/filters/http/response_map/BUILD
+++ b/source/extensions/filters/http/response_map/BUILD
@@ -20,6 +20,7 @@ envoy_cc_library(
         "//include/envoy/http:codes_interface",
         "//include/envoy/http:filter_interface",
         "//source/common/response_map:response_map_lib",
+        "//source/extensions/filters/http:well_known_names",
         "//source/common/buffer:buffer_lib",
         "//source/common/common:assert_lib",
         "//source/common/common:enum_to_int",
diff --git a/source/extensions/filters/http/response_map/config.cc b/source/extensions/filters/http/response_map/config.cc
index 9b3cbdabf8996..3133412ea026d 100644
--- a/source/extensions/filters/http/response_map/config.cc
+++ b/source/extensions/filters/http/response_map/config.cc
@@ -11,7 +11,8 @@ namespace ResponseMapFilter {
 
 Http::FilterFactoryCb ResponseMapFilterFactory::createFilterFactoryFromProtoTyped(
     const envoy::extensions::filters::http::response_map::v3::ResponseMap& proto_config,
-    const std::string& stats_prefix, Server::Configuration::FactoryContext& context) {
+    const std::string& stats_prefix,
+    Server::Configuration::FactoryContext& context) {
   ResponseMapFilterConfigSharedPtr config =
       std::make_shared<ResponseMapFilterConfig>(proto_config, stats_prefix, context);
   return [config](Http::FilterChainFactoryCallbacks& callbacks) -> void {
@@ -19,6 +20,14 @@ Http::FilterFactoryCb ResponseMapFilterFactory::createFilterFactoryFromProtoType
   };
 }
 
+Router::RouteSpecificFilterConfigConstSharedPtr
+ResponseMapFilterFactory::createRouteSpecificFilterConfigTyped(
+    const envoy::extensions::filters::http::response_map::v3::ResponseMapPerRoute& proto_config,
+    Server::Configuration::ServerFactoryContext&,
+    ProtobufMessage::ValidationVisitor&) {
+  return std::make_shared<FilterConfigPerRoute>(proto_config);
+}
+
 /**
  * Static registration for the response_map filter. @see RegisterFactory.
  */
diff --git a/source/extensions/filters/http/response_map/config.h b/source/extensions/filters/http/response_map/config.h
index 5f92b8934b3f8..7c38beba643c7 100644
--- a/source/extensions/filters/http/response_map/config.h
+++ b/source/extensions/filters/http/response_map/config.h
@@ -2,6 +2,7 @@
 
 #include "envoy/extensions/filters/http/response_map/v3/response_map.pb.h"
 #include "envoy/extensions/filters/http/response_map/v3/response_map.pb.validate.h"
+#include "envoy/server/filter_config.h"
 
 #include "extensions/filters/http/common/factory_base.h"
 #include "extensions/filters/http/well_known_names.h"
@@ -16,13 +17,20 @@ namespace ResponseMapFilter {
  */
 class ResponseMapFilterFactory
     : public Common::FactoryBase<
-          envoy::extensions::filters::http::response_map::v3::ResponseMap> {
+          envoy::extensions::filters::http::response_map::v3::ResponseMap,
+          envoy::extensions::filters::http::response_map::v3::ResponseMapPerRoute> {
 public:
   ResponseMapFilterFactory() : FactoryBase(HttpFilterNames::get().ResponseMap) {}
 
   Http::FilterFactoryCb createFilterFactoryFromProtoTyped(
       const envoy::extensions::filters::http::response_map::v3::ResponseMap& proto_config,
       const std::string& stats_prefix, Server::Configuration::FactoryContext& context) override;
+
+private:
+  Router::RouteSpecificFilterConfigConstSharedPtr createRouteSpecificFilterConfigTyped(
+      const envoy::extensions::filters::http::response_map::v3::ResponseMapPerRoute& proto_config,
+      Server::Configuration::ServerFactoryContext& context,
+      ProtobufMessage::ValidationVisitor& validator) override;
 };
 
 } // namespace ResponseMapFilter
diff --git a/source/extensions/filters/http/response_map/response_map_filter.cc b/source/extensions/filters/http/response_map/response_map_filter.cc
index 3c3fa33fd1eed..a0de46e132a80 100644
--- a/source/extensions/filters/http/response_map/response_map_filter.cc
+++ b/source/extensions/filters/http/response_map/response_map_filter.cc
@@ -3,11 +3,14 @@
 #include "envoy/http/codes.h"
 #include "envoy/http/header_map.h"
 
+#include "extensions/filters/http/well_known_names.h"
+
 #include "common/common/empty_string.h"
 #include "common/common/enum_to_int.h"
 #include "common/common/logger.h"
 #include "common/http/header_map_impl.h"
 #include "common/http/headers.h"
+#include "common/http/utility.h"
 
 namespace Envoy {
 namespace Extensions {
@@ -26,21 +29,44 @@ ResponseMapFilter::ResponseMapFilter(ResponseMapFilterConfigSharedPtr config)
 Http::FilterHeadersStatus ResponseMapFilter::decodeHeaders(Http::RequestHeaderMap& request_headers,
                                                            bool end_stream) {
   ENVOY_LOG(trace, "response map filter: decodeHeaders with end_stream = {}", end_stream);
+
+  // Disable filter per route config if applies
+  if (decoder_callbacks_->route() != nullptr) {
+    const auto* per_route_config =
+        Http::Utility::resolveMostSpecificPerFilterConfig<FilterConfigPerRoute>(
+            Extensions::HttpFilters::HttpFilterNames::get().ResponseMap,
+            decoder_callbacks_->route());
+    ENVOY_LOG(trace, "response map filter: found route. has per_route_config? {}",
+        per_route_config != nullptr);
+    if (per_route_config != nullptr && per_route_config->disabled()) {
+      ENVOY_LOG(trace, "response map filter: disabling due to per_route_config");
+      disabled_ = true;
+      return Http::FilterHeadersStatus::Continue;
+    }
+  }
+
   request_headers_ = &request_headers;
   return Http::FilterHeadersStatus::Continue;
 }
 
 Http::FilterHeadersStatus ResponseMapFilter::encodeHeaders(Http::ResponseHeaderMap& headers,
                                                            bool end_stream) {
-  ENVOY_LOG(trace, "response map filter: encodeHeaders with http status = {} and end_stream = {}",
-      headers.getStatusValue(), end_stream);
+  ENVOY_LOG(trace,
+      "response map filter: encodeHeaders with http status = {}, end_stream = {}, disabled = {}",
+      headers.getStatusValue(), end_stream, disabled_);
+
+  // If this filter is disabled, continue without doing anything.
+  if (disabled_) {
+    return Http::FilterHeadersStatus::Continue;
+  }
 
   // Save a reference to the response headers. If we end up rewriting the response,
   // we'll need to set the content-length (and possibly other) headers later.
   response_headers_ = &headers;
 
   // Check whether we should rewrite this response based on response headers.
-  do_rewrite_ = config_->response_map()->match(request_headers_, headers, encoder_callbacks_->streamInfo());
+  do_rewrite_ = config_->response_map()->match(
+      request_headers_, headers, encoder_callbacks_->streamInfo());
   ENVOY_LOG(trace, "response map filter: do_rewrite_ {}", do_rewrite_);
 
   // If we decided not to rewrite the response, simply pass through to other
@@ -61,9 +87,16 @@ Http::FilterHeadersStatus ResponseMapFilter::encodeHeaders(Http::ResponseHeaderM
   return Http::FilterHeadersStatus::Continue;
 }
 
-Http::FilterDataStatus ResponseMapFilter::encodeData(Buffer::Instance& data, bool end_stream) {
-  ENVOY_LOG(trace, "response map filter: encodeData with data length {} and end_stream = {}",
-      data.length(), end_stream);
+Http::FilterDataStatus ResponseMapFilter::encodeData(Buffer::Instance& data,
+                                                     bool end_stream) {
+  ENVOY_LOG(trace,
+      "response map filter: encodeData with data length {}, end_stream = {}, disabled = {}",
+      data.length(), end_stream, disabled_);
+
+  // If this filter is disabled, continue without doing anything.
+  if (disabled_) {
+    return Http::FilterDataStatus::Continue;
+  }
 
   // If we decided not to rewrite the response, simply pass through to other
   // filters.
@@ -94,6 +127,11 @@ void ResponseMapFilter::doRewrite(void) {
   ENVOY_LOG(trace, "response map filter: doRewrite with {} encoding_buffer",
       encoding_buffer != nullptr ? "non-null" : "null");
 
+  // If this route is disabled, we should never be doing a rewrite.
+  // In fact, we never should have even checked if we should do
+  // a rewrite.
+  ASSERT(!disabled_);
+
   // We should either see no encoding buffer or an empty encoding buffer.
   //
   // We'll see no encoding buffer if the upstream response was never observed
diff --git a/source/extensions/filters/http/response_map/response_map_filter.h b/source/extensions/filters/http/response_map/response_map_filter.h
index 04a46d57ba6ff..2b05dda88d3a0 100644
--- a/source/extensions/filters/http/response_map/response_map_filter.h
+++ b/source/extensions/filters/http/response_map/response_map_filter.h
@@ -25,6 +25,18 @@ class ResponseMapFilterConfig {
 };
 using ResponseMapFilterConfigSharedPtr = std::shared_ptr<ResponseMapFilterConfig>;
 
+class FilterConfigPerRoute : public Router::RouteSpecificFilterConfig {
+public:
+  FilterConfigPerRoute(
+      const envoy::extensions::filters::http::response_map::v3::ResponseMapPerRoute&
+          config)
+      : disabled_(config.disabled()) {}
+  bool disabled() const { return disabled_; }
+
+private:
+  bool disabled_;
+};
+
 class ResponseMapFilter : public Http::StreamFilter, Logger::Loggable<Logger::Id::filter> {
 public:
   ResponseMapFilter(ResponseMapFilterConfigSharedPtr config);
@@ -71,6 +83,7 @@ class ResponseMapFilter : public Http::StreamFilter, Logger::Loggable<Logger::Id
   Http::ResponseHeaderMap* response_headers_{};
   Http::RequestHeaderMap* request_headers_{};
   bool do_rewrite_{};
+  bool disabled_{};
 };
 
 } // namespace ResponseMapFilter