diff --git a/lib/auth/auth_with_roles.go b/lib/auth/auth_with_roles.go
index 632be2ac25a4b..297be4a6b6c4d 100644
--- a/lib/auth/auth_with_roles.go
+++ b/lib/auth/auth_with_roles.go
@@ -73,6 +73,7 @@ import (
 	"github.com/gravitational/teleport/lib/services"
 	"github.com/gravitational/teleport/lib/services/local"
 	"github.com/gravitational/teleport/lib/session"
+	"github.com/gravitational/teleport/lib/tlsca"
 	"github.com/gravitational/teleport/lib/utils"
 )
 
@@ -4778,9 +4779,44 @@ func (a *ServerWithRoles) ProcessKubeCSR(req KubeCSR) (*KubeCSRResponse, error)
 	if !a.hasBuiltinRole(types.RoleProxy) {
 		return nil, trace.AccessDenied("this request can be only executed by a proxy")
 	}
+	clusterName, err := a.GetClusterName()
+	if err != nil {
+		return nil, trace.Wrap(err)
+	}
+	proxyClusterName := a.context.Identity.GetIdentity().TeleportCluster
+	identityClusterName, err := extractOriginalClusterNameFromCSR(req)
+	if err != nil {
+		return nil, trace.Wrap(err)
+	}
+	if proxyClusterName != "" &&
+		proxyClusterName != clusterName.GetClusterName() &&
+		proxyClusterName != identityClusterName {
+		log.WithFields(
+			logrus.Fields{
+				"proxy_cluster_name":    proxyClusterName,
+				"identity_cluster_name": identityClusterName,
+			},
+		).Warn("KubeCSR request denied because the proxy and identity clusters didn't match")
+		return nil, trace.AccessDenied("can not sign certs for users via a different cluster proxy")
+	}
 	return a.authServer.ProcessKubeCSR(req)
 }
 
+func extractOriginalClusterNameFromCSR(req KubeCSR) (string, error) {
+	csr, err := tlsca.ParseCertificateRequestPEM(req.CSR)
+	if err != nil {
+		return "", trace.Wrap(err)
+	}
+
+	// Extract identity from the CSR. Pass zero time for id.Expiry, it won't be
+	// used here.
+	id, err := tlsca.FromSubject(csr.Subject, time.Time{})
+	if err != nil {
+		return "", trace.Wrap(err)
+	}
+	return id.TeleportCluster, nil
+}
+
 // GetDatabaseServers returns all registered database servers.
 func (a *ServerWithRoles) GetDatabaseServers(ctx context.Context, namespace string, opts ...services.MarshalOption) ([]types.DatabaseServer, error) {
 	if err := a.action(namespace, types.KindDatabaseServer, types.VerbList, types.VerbRead); err != nil {
diff --git a/lib/auth/middleware.go b/lib/auth/middleware.go
index 8046ebb6522d5..ec8107fb1d373 100644
--- a/lib/auth/middleware.go
+++ b/lib/auth/middleware.go
@@ -665,7 +665,8 @@ func (a *Middleware) ServeHTTP(w http.ResponseWriter, r *http.Request) {
 			return
 		}
 
-		if user, err = a.extractIdentityFromImpersonationHeader(impersonateUser); err != nil {
+		proxyClusterName := user.GetIdentity().TeleportCluster
+		if user, err = a.extractIdentityFromImpersonationHeader(proxyClusterName, impersonateUser); err != nil {
 			trace.WriteError(w, err)
 			return
 		}
@@ -791,7 +792,7 @@ func isProxyRole(identity authz.IdentityGetter) bool {
 // extractIdentityFromImpersonationHeader extracts the identity from the impersonation
 // header and returns it. If the impersonation header holds an identity of a
 // system role, an error is returned.
-func (a *Middleware) extractIdentityFromImpersonationHeader(impersonate string) (authz.IdentityGetter, error) {
+func (a *Middleware) extractIdentityFromImpersonationHeader(proxyCluster string, impersonate string) (authz.IdentityGetter, error) {
 	// Unmarshal the impersonated user from the header.
 	var impersonatedIdentity tlsca.Identity
 	if err := json.Unmarshal([]byte(impersonate), &impersonatedIdentity); err != nil {
@@ -803,6 +804,11 @@ func (a *Middleware) extractIdentityFromImpersonationHeader(impersonate string)
 		// make sure that this user does not have system role
 		// since system roles are not allowed to be impersonated.
 		return nil, trace.AccessDenied("can not impersonate a system role")
+	case proxyCluster != "" && proxyCluster != a.ClusterName && proxyCluster != impersonatedIdentity.TeleportCluster:
+		// If a remote proxy is impersonating a user from a different cluster, we
+		// must reject the request. This is because the proxy is not allowed to
+		// impersonate a user from a different cluster.
+		return nil, trace.AccessDenied("can not impersonate users via a different cluster proxy")
 	case impersonatedIdentity.TeleportCluster != a.ClusterName:
 		// if the impersonated user is from a different cluster, we need to
 		// use him as remote user.
diff --git a/lib/auth/middleware_test.go b/lib/auth/middleware_test.go
index 19e0688317d40..193e1be7a303e 100644
--- a/lib/auth/middleware_test.go
+++ b/lib/auth/middleware_test.go
@@ -361,6 +361,15 @@ func TestMiddleware_ServeHTTP(t *testing.T) {
 		Principals:      []string{},
 	}
 
+	remoteProxyIdentity := tlsca.Identity{
+		Username:        "proxy...",
+		Groups:          []string{string(types.RoleProxy)},
+		TeleportCluster: remoteClusterName,
+		Expires:         now,
+		Usage:           []string{},
+		Principals:      []string{},
+	}
+
 	dbIdentity := tlsca.Identity{
 		Username:        "db...",
 		Groups:          []string{string(types.RoleDatabase)},
@@ -381,11 +390,12 @@ func TestMiddleware_ServeHTTP(t *testing.T) {
 		userIPAddr string
 	}
 	tests := []struct {
-		name                         string
-		args                         args
-		want                         want
-		credentialsForwardingDennied bool
-		enableCredentialsForwarding  bool
+		name                                  string
+		args                                  args
+		want                                  want
+		credentialsForwardingDennied          bool
+		enableCredentialsForwarding           bool
+		impersonateLocalUserViaRemoteProxyErr bool
 	}{
 		{
 			name: "local user without impersonation",
@@ -549,6 +559,21 @@ func TestMiddleware_ServeHTTP(t *testing.T) {
 			credentialsForwardingDennied: false,
 			enableCredentialsForwarding:  false,
 		},
+		{
+			name: "remote proxy with local user impersonation",
+			args: args{
+				peers: []*x509.Certificate{{
+					Subject:  subject(t, remoteProxyIdentity),
+					NotAfter: now,
+					Issuer:   pkix.Name{Organization: []string{remoteClusterName}},
+				}},
+				impersonateIdentity: &localUserIdentity,
+				sourceIPAddr:        "127.0.0.1:6514",
+				impersonatedIPAddr:  "127.0.0.2:6514",
+			},
+			enableCredentialsForwarding:           true,
+			impersonateLocalUserViaRemoteProxyErr: true,
+		},
 	}
 	for _, tt := range tests {
 		t.Run(tt.name, func(t *testing.T) {
@@ -593,6 +618,14 @@ func TestMiddleware_ServeHTTP(t *testing.T) {
 					),
 				)
 			}
+			if tt.impersonateLocalUserViaRemoteProxyErr {
+				require.True(t,
+					bytes.Contains(
+						rsp.Body.Bytes(),
+						[]byte("can not impersonate users via a different cluster proxy"),
+					),
+				)
+			}
 		})
 	}
 }