diff --git a/gcloud/storage/blob.py b/gcloud/storage/blob.py
index 6b1280a31289..c852c5e7c816 100644
--- a/gcloud/storage/blob.py
+++ b/gcloud/storage/blob.py
@@ -18,6 +18,7 @@
 import copy
 import hashlib
 from io import BytesIO
+from io import UnsupportedOperation
 import json
 import mimetypes
 import os
@@ -491,10 +492,11 @@ def upload_from_file(self, file_obj, rewind=False, size=None,
         total_bytes = size
         if total_bytes is None:
             if hasattr(file_obj, 'fileno'):
-                total_bytes = os.fstat(file_obj.fileno()).st_size
-            else:
-                raise ValueError('total bytes could not be determined. Please '
-                                 'pass an explicit size.')
+                try:
+                    total_bytes = os.fstat(file_obj.fileno()).st_size
+                except (OSError, UnsupportedOperation):
+                    pass  # Assuming fd is not an actual file (maybe socket).
+
         headers = {
             'Accept': 'application/json',
             'Accept-Encoding': 'gzip, deflate',
@@ -510,6 +512,13 @@ def upload_from_file(self, file_obj, rewind=False, size=None,
         if self.chunk_size is not None:
             upload.chunksize = self.chunk_size
 
+            if total_bytes is None:
+                upload.strategy = RESUMABLE_UPLOAD
+        elif total_bytes is None:
+            raise ValueError('total bytes could not be determined. Please '
+                             'pass an explicit size, or supply a chunk size '
+                             'for a streaming transfer.')
+
         url_builder = _UrlBuilder(bucket_name=self.bucket.name,
                                   object_name=self.name)
         upload_config = _UploadConfig()
diff --git a/gcloud/storage/test_blob.py b/gcloud/storage/test_blob.py
index 3ae92ed76a3d..0259a1613f8a 100644
--- a/gcloud/storage/test_blob.py
+++ b/gcloud/storage/test_blob.py
@@ -507,6 +507,102 @@ def _upload_from_file_simple_test_helper(self, properties=None,
         self.assertEqual(headers['Content-Length'], '6')
         self.assertEqual(headers['Content-Type'], expected_content_type)
 
+    def test_upload_from_file_stream(self):
+        from six.moves.http_client import OK
+        from six.moves.urllib.parse import parse_qsl
+        from six.moves.urllib.parse import urlsplit
+        from gcloud.streaming import http_wrapper
+
+        BLOB_NAME = 'blob-name'
+        UPLOAD_URL = 'http://example.com/upload/name/key'
+        DATA = b'ABCDE'
+        loc_response = {'status': OK, 'location': UPLOAD_URL}
+        chunk1_response = {'status': http_wrapper.RESUME_INCOMPLETE,
+                           'range': 'bytes 0-4'}
+        chunk2_response = {'status': OK}
+        # Need valid JSON on last response, since resumable.
+        connection = _Connection(
+            (loc_response, b''),
+            (chunk1_response, b''),
+            (chunk2_response, b'{}'),
+        )
+        client = _Client(connection)
+        bucket = _Bucket(client)
+        blob = self._makeOne(BLOB_NAME, bucket=bucket)
+        blob._CHUNK_SIZE_MULTIPLE = 1
+        blob.chunk_size = 5
+
+        from gcloud.streaming.test_transfer import _Stream
+        file_obj = _Stream(DATA)
+
+        # Mock stream closes at end of data, like a socket might
+        def is_stream_closed(stream):
+            if stream.tell() < len(DATA):
+                return stream._closed
+            else:
+                return stream.close() or True
+
+        _Stream.closed = property(is_stream_closed)
+
+        def fileno_mock():
+            from io import UnsupportedOperation
+            raise UnsupportedOperation()
+
+        file_obj.fileno = fileno_mock
+
+        blob.upload_from_file(file_obj)
+
+        # Remove the temp property
+        delattr(_Stream, "closed")
+
+        rq = connection.http._requested
+        self.assertEqual(len(rq), 3)
+
+        # Requested[0]
+        headers = dict(
+            [(x.title(), str(y)) for x, y in rq[0].pop('headers').items()])
+        self.assertEqual(headers['Content-Length'], '0')
+        self.assertEqual(headers['X-Upload-Content-Type'],
+                         'application/octet-stream')
+
+        uri = rq[0].pop('uri')
+        scheme, netloc, path, qs, _ = urlsplit(uri)
+        self.assertEqual(scheme, 'http')
+        self.assertEqual(netloc, 'example.com')
+        self.assertEqual(path, '/b/name/o')
+        self.assertEqual(dict(parse_qsl(qs)),
+                         {'uploadType': 'resumable', 'name': BLOB_NAME})
+        self.assertEqual(rq[0], {
+            'method': 'POST',
+            'body': '',
+            'connection_type': None,
+            'redirections': 5,
+        })
+
+        # Requested[1]
+        headers = dict(
+            [(x.title(), str(y)) for x, y in rq[1].pop('headers').items()])
+        self.assertEqual(headers['Content-Range'], 'bytes 0-4/*')
+        self.assertEqual(rq[1], {
+            'method': 'PUT',
+            'uri': UPLOAD_URL,
+            'body': DATA[:5],
+            'connection_type': None,
+            'redirections': 5,
+        })
+
+        # Requested[2]
+        headers = dict(
+            [(x.title(), str(y)) for x, y in rq[2].pop('headers').items()])
+        self.assertEqual(headers['Content-Range'], 'bytes */5')
+        self.assertEqual(rq[2], {
+            'method': 'PUT',
+            'uri': UPLOAD_URL,
+            'body': DATA[5:],
+            'connection_type': None,
+            'redirections': 5,
+        })
+
     def test_upload_from_file_simple(self):
         self._upload_from_file_simple_test_helper(
             expected_content_type='application/octet-stream')
diff --git a/gcloud/streaming/buffered_stream.py b/gcloud/streaming/buffered_stream.py
index 6ce9299e701d..bf5dc66550d4 100644
--- a/gcloud/streaming/buffered_stream.py
+++ b/gcloud/streaming/buffered_stream.py
@@ -20,7 +20,12 @@ def __init__(self, stream, start, size):
         self._stream = stream
         self._start_pos = start
         self._buffer_pos = 0
-        self._buffered_data = self._stream.read(size)
+
+        if not hasattr(self._stream, 'closed') or not self._stream.closed:
+            self._buffered_data = self._stream.read(size)
+        else:
+            self._buffered_data = b''
+
         self._stream_at_end = len(self._buffered_data) < size
         self._end_pos = self._start_pos + len(self._buffered_data)
 
diff --git a/gcloud/streaming/transfer.py b/gcloud/streaming/transfer.py
index 4c5b2a7a23f8..7ef439d67f36 100644
--- a/gcloud/streaming/transfer.py
+++ b/gcloud/streaming/transfer.py
@@ -1038,14 +1038,16 @@ def stream_file(self, use_chunks=True):
                     'Failed to transfer all bytes in chunk, upload paused at '
                     'byte %d' % self.progress)
         if self.complete and hasattr(self.stream, 'seek'):
-            current_pos = self.stream.tell()
-            self.stream.seek(0, os.SEEK_END)
-            end_pos = self.stream.tell()
-            self.stream.seek(current_pos)
-            if current_pos != end_pos:
-                raise TransferInvalidError(
-                    'Upload complete with %s additional bytes left in stream' %
-                    (int(end_pos) - int(current_pos)))
+            if not hasattr(self.stream, 'seekable') or self.stream.seekable():
+                current_pos = self.stream.tell()
+                self.stream.seek(0, os.SEEK_END)
+                end_pos = self.stream.tell()
+                self.stream.seek(current_pos)
+                if current_pos != end_pos:
+                    raise TransferInvalidError(
+                        'Upload complete with %s '
+                        'additional bytes left in stream' %
+                        (int(end_pos) - int(current_pos)))
         return response
 
     def _send_media_request(self, request, end):