diff --git a/setup.py b/setup.py
index c89b05d1d..2c81e1b17 100644
--- a/setup.py
+++ b/setup.py
@@ -22,18 +22,13 @@
 DEPENDENCIES = (
     "cachetools>=2.0.0,<6.0",
     "pyasn1-modules>=0.2.1",
-    # rsa==4.5 is the last version to support 2.7
-    # https://github.com/sybrenstuvel/python-rsa/issues/152#issuecomment-643470233
-    'rsa<4.6; python_version < "3.6"',
-    'rsa>=3.1.4,<5; python_version >= "3.6"',
-    # install enum34 to support 2.7. enum34 only works up to python version 3.3.
-    'enum34>=1.1.10; python_version < "3.4"',
+    'rsa>=3.1.4,<5',
     "six>=1.9.0",
 )
 
 extras = {
     "aiohttp": [
-        "aiohttp >= 3.6.2, < 4.0.0dev; python_version>='3.6'",
+        "aiohttp >= 3.6.2, < 4.0.0dev",
         "requests >= 2.20.0, < 3.0.0dev",
     ],
     "pyopenssl": ["pyopenssl>=20.0.0", "cryptography>=38.0.3"],
@@ -66,7 +61,7 @@
     namespace_packages=("google",),
     install_requires=DEPENDENCIES,
     extras_require=extras,
-    python_requires=">=2.7,!=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*,!=3.4.*,!=3.5.*",
+    python_requires=">=3.6",
     license="Apache 2.0",
     keywords="google auth oauth client",
     classifiers=[