diff --git a/bumble/transport/pyusb.py b/bumble/transport/pyusb.py
index 61ce17e2..68a1dfd9 100644
--- a/bumble/transport/pyusb.py
+++ b/bumble/transport/pyusb.py
@@ -23,11 +23,24 @@
 import usb.core
 import usb.util
 
+from typing import Optional
+from usb.core import Device as UsbDevice
+from usb.core import USBError
+from usb.util import CTRL_TYPE_CLASS, CTRL_RECIPIENT_OTHER
+from usb.legacy import REQ_SET_FEATURE, REQ_CLEAR_FEATURE, CLASS_HUB
+
 from .common import Transport, ParserSource
 from .. import hci
 from ..colors import color
 
 
+# -----------------------------------------------------------------------------
+# Constant
+# -----------------------------------------------------------------------------
+USB_PORT_FEATURE_POWER = 8
+POWER_CYCLE_DELAY = 1
+RESET_DELAY = 3
+
 # -----------------------------------------------------------------------------
 # Logging
 # -----------------------------------------------------------------------------
@@ -214,6 +227,10 @@ async def close(self):
         usb_find = libusb_package.find
 
     # Find the device according to the spec moniker
+    power_cycle = False
+    if spec.startswith('!'):
+        power_cycle = True
+        spec = spec[1:]
     if ':' in spec:
         vendor_id, product_id = spec.split(':')
         device = usb_find(idVendor=int(vendor_id, 16), idProduct=int(product_id, 16))
@@ -245,6 +262,14 @@ def device_path(device):
         raise ValueError('device not found')
     logger.debug(f'USB Device: {device}')
 
+    # Power Cycle the device
+    if power_cycle:
+        try:
+            device = await _power_cycle(device)  # type: ignore
+        except Exception as e:
+            logging.debug(e)
+            logging.info(f"Unable to power cycle {hex(device.idVendor)} {hex(device.idProduct)}")  # type: ignore
+
     # Collect the metadata
     device_metadata = {'vendor_id': device.idVendor, 'product_id': device.idProduct}
 
@@ -308,3 +333,73 @@ def device_path(device):
     packet_sink.start()
 
     return UsbTransport(device, packet_source, packet_sink)
+
+
+async def _power_cycle(device: UsbDevice) -> UsbDevice:
+    """
+    For devices connected to compatible USB hubs: Performs a power cycle on a given USB device.
+    This involves temporarily disabling its port on the hub and then re-enabling it.
+    """
+    device_path = f'{device.bus}-{".".join(map(str, device.port_numbers))}'  # type: ignore
+    hub = _find_hub_by_device_path(device_path)
+
+    if hub:
+        try:
+            device_port = device.port_numbers[-1]  # type: ignore
+            _set_port_status(hub, device_port, False)
+            await asyncio.sleep(POWER_CYCLE_DELAY)
+            _set_port_status(hub, device_port, True)
+            await asyncio.sleep(RESET_DELAY)
+
+            # Device needs to be find again otherwise it will appear as disconnected
+            return usb.core.find(idVendor=device.idVendor, idProduct=device.idProduct)  # type: ignore
+        except USBError as e:
+            logger.error(f"Adjustment needed: Please revise the udev rule for device {hex(device.idVendor)}:{hex(device.idProduct)} for proper recognition.")  # type: ignore
+            logger.error(e)
+
+    return device
+
+
+def _set_port_status(device: UsbDevice, port: int, on: bool):
+    """Sets the power status of a specific port on a USB hub."""
+    device.ctrl_transfer(
+        bmRequestType=CTRL_TYPE_CLASS | CTRL_RECIPIENT_OTHER,
+        bRequest=REQ_SET_FEATURE if on else REQ_CLEAR_FEATURE,
+        wIndex=port,
+        wValue=USB_PORT_FEATURE_POWER,
+    )
+
+
+def _find_device_by_path(sys_path: str) -> Optional[UsbDevice]:
+    """Finds a USB device based on its system path."""
+    bus_num, *port_parts = sys_path.split('-')
+    ports = [int(port) for port in port_parts[0].split('.')]
+    devices = usb.core.find(find_all=True, bus=int(bus_num))
+    if devices:
+        for device in devices:
+            if device.bus == int(bus_num) and list(device.port_numbers) == ports:  # type: ignore
+                return device
+
+    return None
+
+
+def _find_hub_by_device_path(sys_path: str) -> Optional[UsbDevice]:
+    """Finds the USB hub associated with a specific device path."""
+    hub_sys_path = sys_path.rsplit('.', 1)[0]
+    hub_device = _find_device_by_path(hub_sys_path)
+
+    if hub_device is None:
+        return None
+    else:
+        return hub_device if _is_hub(hub_device) else None
+
+
+def _is_hub(device: UsbDevice) -> bool:
+    """Checks if a USB device is a hub"""
+    if device.bDeviceClass == CLASS_HUB:  # type: ignore
+        return True
+    for config in device:
+        for interface in config:
+            if interface.bInterfaceClass == CLASS_HUB:  # type: ignore
+                return True
+    return False