-
Notifications
You must be signed in to change notification settings - Fork 1
/
index.html
670 lines (628 loc) · 57.8 KB
/
index.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
<!DOCTYPE html>
<html lang="en">
<head>
<!-- Global site tag (gtag.js) - Google Analytics -->
<script async src="https://www.googletagmanager.com/gtag/js?id=UA-135435972-1"></script>
<script>
window.dataLayer = window.dataLayer || [];
function gtag(){dataLayer.push(arguments);}
gtag('js', new Date());
gtag('config', 'UA-135435972-1');
</script>
<meta charset="utf-8">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<title>Goodarzi Lab @ UCSF</title>
<meta name="description" content="Goodarzi Lab @ UCSF">
<!-- core CSS -->
<link href="css/bootstrap.min.css" rel="stylesheet">
<link href="css/bootstrap-social.css" rel="stylesheet">
<link rel="stylesheet" href="css/academicons.min.css"/>
<link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/font-awesome/4.4.0/css/font-awesome.min.css">
<link href="css/prettyPhoto.css" rel="stylesheet">
<link href="css/main.css" rel="stylesheet">
<link href="css/responsive.css" rel="stylesheet">
<link rel="shortcut icon" type="image/x-icon" href="favicon-flask.ico" />
<!--[if lt IE 9]>
<script src="js/html5shiv.js"></script>
<script src="js/respond.min.js"></script>
<![endif]-->
</head>
<!--/head-->
<body class="homepage">
<header id="header">
<nav class="navbar navbar-inverse" role="banner">
<div class="container">
<div class="navbar-header">
<button type="button" class="navbar-toggle" data-toggle="collapse" data-target=".navbar-collapse"> <span class="sr-only">Toggle navigation</span> <span class="icon-bar"></span> <span class="icon-bar"></span> <span class="icon-bar"></span> </button>
<a class="navbar-brand" href="index.html"><i class="fa fa-flask"></i> Goodarzi Lab</a>
</div>
<div class="collapse navbar-collapse navbar-right">
<ul class="nav navbar-nav">
<li class="active"><a href="index.html">Home</a></li>
<li><a href="research.html">Research</a></li>
<li><a href="publications.html">Publications</a></li>
<li><a href="people.html">People</a></li>
<li><a href="software.html">Software</a></li>
<li><a href="donate.html">Donate</a></li>
<li><a href="positions.html">Positions</a></li>
<li><a href="contact-us.html">Contact</a></li>
</ul>
</div>
</div>
<!--/.container-->
</nav>
<!--/nav-->
</header>
<!--/header-->
<section id="main-slider" class="no-margin">
<div class="carousel slide">
<ol class="carousel-indicators">
<li data-target="#main-slider" data-slide-to="0" class="active"></li>
<li data-target="#main-slider" data-slide-to="1"></li>
<li data-target="#main-slider" data-slide-to="2"></li>
<li data-target="#main-slider" data-slide-to="3"></li>
<li data-target="#main-slider" data-slide-to="4"></li>
<li data-target="#main-slider" data-slide-to="5"></li>
</ol>
<div class="carousel-inner">
<div class="item active" style="background-image: url(images/slider/bg1.jpg)">
<div class="container">
<div class="row slide-margin">
<div class="col-sm-12">
<div class="carousel-content">
<h1>Welcome to Goodarzi Lab @UCSF</h1>
<h2><strong>We build integrated machine learning models & experimental frameworks to fuel discovery in cancer systems biology and translational genomics</strong></h2>
<h2>Department of Biochemistry & Biophysics</h2>
<h2>Department of Urology</h2>
<h2>Helen Diller Family Comprehensive Cancer Center</h2>
<h2>Bakar Computational Health Sciences Institute</h2>
<!--<a class="btn-slide" href="about-us.html">Read More</a>--> </div>
</div>
</div>
</div>
</div>
<!--/.item-->
<div class="item" style="background-image: url(images/slider/bg2.jpg)">
<div class="container">
<div class="row slide-margin">
<div class="col-sm-12">
<div class="carousel-content">
<h1>Welcome to Goodarzi Lab @UCSF</h1>
<h2><strong>We build integrated machine learning models & experimental frameworks to fuel discovery in cancer systems biology and translational genomics</strong></h2>
<h2>Department of Biochemistry & Biophysics</h2>
<h2>Department of Urology</h2>
<h2>Helen Diller Family Comprehensive Cancer Center</h2>
<h2>Bakar Computational Health Sciences Institute</h2>
<!--<a class="btn-slide" href="about-us.html">Read More</a>--> </div>
</div>
</div>
</div>
</div>
<!--/.item-->
<div class="item" style="background-image: url(images/slider/bg3.jpg)">
<div class="container">
<div class="row slide-margin">
<div class="col-sm-12">
<div class="carousel-content">
<h1>Welcome to Goodarzi Lab @UCSF</h1>
<h2><strong>We build integrated machine learning models & experimental frameworks to fuel discovery in cancer systems biology and translational genomics</strong></h2>
<h2>Department of Biochemistry & Biophysics</h2>
<h2>Department of Urology</h2>
<h2>Helen Diller Family Comprehensive Cancer Center</h2>
<h2>Bakar Computational Health Sciences Institute</h2>
<!--<a class="btn-slide" href="about-us.html">Read More</a>--> </div>
</div>
</div>
</div>
</div>
<!--/.item-->
<div class="item" style="background-image: url(images/slider/bg4.jpg)">
<div class="container">
<div class="row slide-margin">
<div class="col-sm-12">
<div class="carousel-content">
<h1>Welcome to Goodarzi Lab @UCSF</h1>
<h2><strong>We build integrated machine learning models & experimental frameworks to fuel discovery in cancer systems biology and translational genomics</strong></h2>
<h2>Department of Biochemistry & Biophysics</h2>
<h2>Department of Urology</h2>
<h2>Helen Diller Family Comprehensive Cancer Center</h2>
<h2>Bakar Computational Health Sciences Institute</h2>
<!--<a class="btn-slide" href="about-us.html">Read More</a>--> </div>
</div>
</div>
</div>
</div>
<!--/.item-->
<div class="item" style="background-image: url(images/slider/bg5.jpg)">
<div class="container">
<div class="row slide-margin">
<div class="col-sm-12">
<div class="carousel-content">
<h1>Welcome to Goodarzi Lab @UCSF</h1>
<h2><strong>We build integrated machine learning models & experimental frameworks to fuel discovery in cancer systems biology and translational genomics</strong></h2>
<h2>Department of Biochemistry & Biophysics</h2>
<h2>Department of Urology</h2>
<h2>Helen Diller Family Comprehensive Cancer Center</h2>
<h2>Bakar Computational Health Sciences Institute</h2>
<!--<a class="btn-slide" href="about-us.html">Read More</a>--> </div>
</div>
</div>
</div>
</div>
<!--/.item-->
<div class="item" style="background-image: url(images/slider/bg6.jpg)">
<div class="container">
<div class="row slide-margin">
<div class="col-sm-12">
<div class="carousel-content">
<h1>Welcome to Goodarzi Lab @UCSF</h1>
<h2><strong>We build integrated machine learning models & experimental frameworks to fuel discovery in cancer systems biology and translational genomics</strong></h2>
<h2>Department of Biochemistry & Biophysics</h2>
<h2>Department of Urology</h2>
<h2>Helen Diller Family Comprehensive Cancer Center</h2>
<h2>Bakar Computational Health Sciences Institute</h2>
<!--<a class="btn-slide" href="about-us.html">Read More</a>--> </div>
</div>
</div>
</div>
</div>
<!--/.item-->
</div>
<!--/.carousel-inner-->
</div>
<!--/.carousel-->
<a class="prev hidden-xs" href="#main-slider" data-slide="prev"> <i class="fa fa-chevron-left"></i> </a> <a class="next hidden-xs" href="#main-slider" data-slide="next"> <i class="fa fa-chevron-right"></i> </a> </section>
<!--/#main-slider-->
<div class="color-border"> </div>
<section id="feature" >
<div class="container">
<div class="center">
<h2>Featured Publications</h2>
<!--<p class="lead">Lorem ipsum dolor sit amet, consectetur adipiscing elit. Proin non odio sed eros tristique bibendum. Nunc quis semper sem.<br> Morbi libero elit elementum quis faucibus ac, condimentum quis nibh.</p>-->
</div>
<div class="row">
<div class="features">
<div class="col-md-2 col-sm-4">
<div class="feature-wrap">
<a href="https://www.nature.com/articles/s43018-023-00554-7"><img class="img-thumbnail" src="images/covers/NatureCancer23.jpg" alt=""></a>
<h2><em>Nature Cancer</em> (2023)</h2>
<h3>A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression.</h3>
</div>
</div>
<div class="col-md-2 col-sm-4">
<div class="feature-wrap"> <!--<i class="fa fa-cogs"></i>-->
<a href="https://www.nature.com/articles/s41556-023-01141-9"><img class="img-thumbnail" src="images/covers/NCB2023.jpg" alt=""></a>
<h2><em>Nature Cell Bio</em> (2023)</h2>
<h3>An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.</h3>
</div>
</div>
<div class="col-md-2 col-sm-4">
<div class="feature-wrap"> <!--<i class="fa fa-cogs"></i>-->
<a href="https://www.nature.com/articles/s41556-022-00856-5"><img class="img-thumbnail" src="images/covers/NCB2022.jpg" alt=""></a>
<h2><em>Nature Cell Bio</em> (2022) 24:307</h2>
<h3>Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics.</h3>
</div>
</div>
<div class="col-md-2 col-sm-4">
<div class="feature-wrap"> <!--<i class="fa fa-cogs"></i>-->
<a href="https://science.sciencemag.org/content/372/6543/eabc7531"><img class="img-thumbnail" src="images/covers/Science2021.jpg" alt=""></a>
<h2><em>Science</em> (2021) 372:eabc7531</h2>
<h3>A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements.</h3>
</div>
</div>
<div class="col-md-2 col-sm-4">
<div class="feature-wrap"> <!--<i class="fa fa-cogs"></i>-->
<a href="https://cancerdiscovery.aacrjournals.org/content/10/9/1410"><img class="img-thumbnail" src="images/covers/CancerDisc2020.jpg" alt=""></a>
<h2><em>Cancer Discovery</em> (2020) 10:1410</h2>
<h3>RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon.</h3>
</div>
</div>
<!--<div class="col-md-2 col-sm-4">
<div class="feature-wrap">
<a href="https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30434-4"><img class="img-thumbnail" src="images/covers/MolCellSep2019.jpg" alt=""></a>
<h2><em>Molecular Cell</em> (2019) 75: 967</h2>
<h3>Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.</h3>
</div>
</div>-->
<!--/.col-md-4-->
<div class="col-md-2 col-sm-4">
<div class="feature-wrap"> <!--<i class="fa fa-rocket"></i>-->
<a href="https://www.nature.com/articles/s41591-018-0230-4"><img class="img-thumbnail" src="images/covers/NatureMedNov18.jpg" alt=""></a>
<h2><em>Nature Medicine</em> (2018) 24: 1743</h2>
<h3>Cancer cells exploit an orphan RNA to drive metastatic progression.</h3>
</div>
</div>
<!--<div class="col-md-2 col-sm-4">
<div class="feature-wrap">
<a href="http://www.cell.com/cell/fulltext/S0092-8674(16)30649-3"><img class="img-thumbnail" src="images/covers/CellJun16.jpg" alt=""></a>
<h2><em>Cell</em> (2016) 165: 1416</h2>
<h3>Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression.</h3>
</div>
</div>-->
<!--/.col-md-4-->
</div>
<!--/.services-->
</div>
<!--/.row-->
</div>
<!--/.container-->
</section>
<!--/#feature-->
<section id="recent-works">
<div class="container">
<div class="center">
<h2>Recent News</h2>
<!--<p class="lead">Lorem ipsum dolor sit amet, consectetur adipiscing elit. Proin non odio sed eros tristique bibendum. Nunc quis semper sem.<br>Morbi libero elit elementum quis faucibus ac, condimentum quis nibh.</p>-->
</div>
<!--/.center-->
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/nqo1.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>An intriguing anti-ferroptotic pathway mediated through sense-antisense NQO1 RNA interactions</h2>
<h3>May 11th, 2023</h3>
<p>We have long been intrigued by the potential regulatory role of interactions between RNA transcripts. Given the ubiquity and potential regulatory role of antisense RNAs, we decided to conduct an unbiased study of antisense RNA in cancer. Using a developed pipeline to profile antisense RNAs, we applied it to an established model of breast cancer metastasis. From our analyses, we identified an antisense RNA, NQO1-AS, whose upregulation promotes breast cancer metastasis. We found that NQO1-AS, by binding directly to its complementary region, stabilizes the NQO1 mRNA, leading to an upregulation of the NQO1 gene product. This enzyme protects cells against oxidative stress, meaning NQO1-AS enables breast cancer cells to become resistant to oxidative damage, reducing their sensitivity to ferroptosis. We established that during metastasis to the lung, cells depend on this NQO1 pathway. We demonstrated that the downregulation of either NQO1 or NQO1-AS significantly decreases lung metastatic burden in a mouse model. This work is published in <a href="https://www.nature.com/articles/s43018-023-00554-7">Nature Cancer</a> and see the excellent <a href="https://cancercommunity.nature.com/posts/a-sense-antisense-rna-interaction-promotes-breast-cancer-metastasis-via-regulation-of-nqo1-expression">blog post</a> written by Kristle Garcia, one of the co-first authors of the study.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression','https://www.nature.com/articles/s43018-023-00554-7')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression','https://www.nature.com/articles/s43018-023-00554-7')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression','https://www.nature.com/articles/s43018-023-00554-7')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/hnrnpc.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>A pro-metastatic link between polyA-site selection and translational control</h2>
<h3>May 9th, 2023</h3>
<p>The impact of translational control on cancer progression is an area of active research. In this study, we employed ribosome profiling to assess the genome-wide translation efficiencies in low and high metastatic breast cancer cells, as well as patient-derived xenografts. Our findings indicate that HNRNPC is downregulated in highly metastatic cells, resulting in the lengthening of the 3' untranslated region in HNRNPC-bound mRNAs and, subsequently, translational suppression. We demonstrated that altering HNRNPC expression affects the metastatic potential of breast cancer cells in xenograft mouse models. Furthermore, lower expression of HNRNPC and its regulon correlates with worse outcomes in breast cancer patient groups. Our results, now published in <a href="https://www.nature.com/articles/s41556-023-01141-9">Nature Cell Bio</a>, also describes a number of computational tools we have developed to study translational control and alternative poly-adenylation. An accompanying <a href="https://www.nature.com/articles/s41556-023-01127-7">News and Views</a> article also puts our work in its broader context here.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('A pro-metastatic link between polyA-site selection and translational control','https://www.nature.com/articles/s41556-023-01141-9')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('A pro-metastatic link between polyA-site selection and translational control','https://www.nature.com/articles/s41556-023-01141-9')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('A pro-metastatic link between polyA-site selection and translational control','https://www.nature.com/articles/s41556-023-01141-9')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/vevo.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>Vevo Therapeutics Launches</h2>
<h3>Dec 8th, 2022</h3>
<p><a href="https://vevo.ai">Vevo Tx</a>, a next-gen drug discovery platform company built on our yet to be published GENEVA frmework, aims to capture patient heterogeneity and the in vivo context early on in the process of drug discovery. See the press release <a href="https://www.prnewswire.com/news-releases/vevo-therapeutics-launches-with-oversubscribed-12m-seed-financing-to-discover-better-drugs-using-higher-resolution-in-vivo-data-generated-at-scale-301697743.html">here</a>.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('Vevo Therapeutics Launches with Oversubscribed $12M Seed Financing to Discover Better Drugs Using Higher Resolution In Vivo Data Generated at Scale','https://www.prnewswire.com/news-releases/vevo-therapeutics-launches-with-oversubscribed-12m-seed-financing-to-discover-better-drugs-using-higher-resolution-in-vivo-data-generated-at-scale-301697743.html')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('Vevo Therapeutics Launches with Oversubscribed $12M Seed Financing to Discover Better Drugs Using Higher Resolution In Vivo Data Generated at Scale','https://www.prnewswire.com/news-releases/vevo-therapeutics-launches-with-oversubscribed-12m-seed-financing-to-discover-better-drugs-using-higher-resolution-in-vivo-data-generated-at-scale-301697743.html')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('Vevo Therapeutics Launches with Oversubscribed $12M Seed Financing to Discover Better Drugs Using Higher Resolution In Vivo Data Generated at Scale','https://www.prnewswire.com/news-releases/vevo-therapeutics-launches-with-oversubscribed-12m-seed-financing-to-discover-better-drugs-using-higher-resolution-in-vivo-data-generated-at-scale-301697743.html')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/sf_gala.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>San Franscisco Discovery Gala</h2>
<h3>Oct 15th, 2022</h3>
<p>American Cancer Society presented the 11th annual San Francisco Discovery Gala on October 15, 2022. Hani was named as the scientific honoree for this event. This Gala is an annual fundraising event to support the American Cancer Society’s mission to save lives, celebrate lives, and lead the fight for a world without cancer. SF Discovery Gala is one of the premier fundraising events for cancer, both locally and across the nation. It garners the support of major corporate partners within the Bay Area and is led by an extraordinary volunteer Board of Ambassadors who champion the mission year-round. See the announcement <a href="https://www.sfdiscoverygala.org/">here</a>.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('SF Discovery Gala 2022','https://www.sfdiscoverygala.org/')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('SF Discovery Gala 2022','https://www.sfdiscoverygala.org/')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('SF Discovery Gala 2022','https://www.sfdiscoverygala.org/')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/t01.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>NIH Director's Transformative Research Award 2022</h2>
<h3>Oct 5th, 2022</h3>
<p>The NIH Director's Transformative Research Award, established in 2009, supports exceptionally innovative, high-risk, original and/or unconventional research projects that have the potential to create or overturn fundamental paradigms. The award is part of the High-Risk, High-Reward Research program of the National Institutes of Health (NIH), which was created to accelerate the pace of biomedical, behavioral, and social science discoveries. We received this award together with our colleagues in Dr. Justin Ichida's group, for a study titled: "Leveraging Natural Phenotypic Variations of Heterogenous ALS Populations-In-A-Dish to Enable Scalable Drug Discovery". This project will extends our GENEVA platform, which was initiatlly developed for cancer research, to neurodegenerative diseases. See the announcement <a href="https://commonfund.nih.gov/tra/recipients">here</a>.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('NIH Director\'s Transformative Research Award 2022','https://commonfund.nih.gov/tra/recipients')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('NIH Director\'s Transformative Research Award 2022','https://commonfund.nih.gov/tra/recipients/')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('NIH Director\'s Transformative Research Award 2022','https://commonfund.nih.gov/tra/recipients')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/biohub_award.jpeg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>The Chan Zuckerberg Biohub Investigator Awards 2021</h2>
<h3>Jan 11th, 2022</h3>
<p>The Chan Zuckerberg Biohub Investigator Program, open to faculty from Stanford University, UC San Francisco, and UC Berkeley, funds innovative, visionary research with the goal of building engaged, collaborative scientific communities to help solve critical challenges in biomedicine.The 86 awardees in our new cohort, who were chosen from nearly 700 applicants through a competitive process judged by nationally recognized external reviewers and a blue-ribbon Selection Advisory Committee, represent a diverse range of disciplines, including basic biological sciences, clinical biomedical sciences, physics, chemistry, engineering, computer and data sciences, statistics, and public health. See the announcement <a href="https://www.czbiohub.org/investigator-competition-2021/">here</a>.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('The Chan Zuckerberg Biohub Investigator Awards 2021','https://www.czbiohub.org/investigator-competition-2021/')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('The Chan Zuckerberg Biohub Investigator Awards 2021','https://www.czbiohub.org/investigator-competition-2021/')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('The Chan Zuckerberg Biohub Investigator Awards 2021','https://www.czbiohub.org/investigator-competition-2021/')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/exailogo.png">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>Exai Bio Launches</h2>
<h3>Nov 10th, 2021</h3>
<p><a href="https://exai.bio">Exai Bio</a>, a next-generation liquid biopsy company, recently launched to bring our orphan non-coding RNA species (<a href="https://www.nature.com/articles/s41591-018-0230-4">oncRNAs</a>) to the clinic. With $65M in financing will bring to bear resources that is needed to not only detect the presence of tumors, but also peer into their biology without a need for invasive biopsies. This work was spearhead by Dr. Lisa Fish, a former postdoc in the lab (and now Director of Research at Exai Bio). See the press release <a href="https://exai.bio/press-release/index.html">here</a>.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('Exai Bio Secures $67.5 Million Series A','https://exai.bio/press-release/index.html')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('Exai Bio Secures $67.5 Million Series A','https://exai.bio/press-release/index.html')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('Exai Bio Secures $67.5 Million Series A','https://exai.bio/press-release/index.html')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/vilcek.png">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>The Vilcek Prizes for Creative Promise in Biomedical Science</h2>
<h3>Sep 9th, 2021</h3>
<p>The Vilcek Prizes for Creative Promise in Biomedical Science are awarded to young foreign- born scientists living and working in the United States. Prizewinners are selected for the innovative promise of their early-career work: research and discoveries that represent a major step forward in their respective area of study, and advance the landscape of scientific research in the United States. Markita del Carpio Landry, Hani Goodarzi, and Harris Wang are the recipients of the 2022 Vilcek Prizes for Creative Promise in Biomedical Science. The Vilcek Foundation raises awareness of immigrant contributions in the United States and fosters appreciation for the arts and sciences. The foundation was established in 2000 by Jan and Marica Vilcek, immigrants from the former Czechoslovakia. See the announcement <a href="https://vilcek.org/prizes/vilcek-prizes-for-creative-promise/">here</a>.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('The Vilcek Prizes for Creative Promise in Biomedical Science','https://vilcek.org/prizes/vilcek-prizes-for-creative-promise/')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('The Vilcek Prizes for Creative Promise in Biomedical Science','https://vilcek.org/prizes/vilcek-prizes-for-creative-promise/)" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('The Vilcek Prizes for Creative Promise in Biomedical Science','https://vilcek.org/prizes/vilcek-prizes-for-creative-promise/')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<!--/.center-->
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/snrpa1.png">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>Discovery and targeting of a novel pro-metastatic regulatory program of RNA splicing</h2>
<h3>May 18th, 2021</h3>
<p>Cancer progression accompanies broad dysregulations in the splicing landscape of the cell. Building on our earlier work on RNA structural elements, we have now discovered a previously unknown structured element that is associated with increased exon inclusion. We revealed that SNRPA1, a core component of the spliceosome, moonlights as a regualtor of RNA splicing via its interactions with these elements. We also showed that SNRPA1, which is up-regulated in highly metastatic cells, acts as a driver of breast cancer metastasis by modulating isoform levels for specific target genes. Morpholino-based reversal of SNRPA1-mediated changes converts the cell into a less malignant state. Our results, now published in <a href="https://science.sciencemag.org/content/372/6543/eabc7531">Science</a>, also demonstrates the utility of hybrid computational/experimental platforms as potent engines of discovery. For a lay description of this study, see the write up by Jeff Norris puiblished <a href="https://www.ucsf.edu/news/2021/05/420546/spread-breast-cancer-linked-newly-discovered-rna-splicing-mechanism">here</a>.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements','https://science.sciencemag.org/content/372/6543/eabc7531')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements','https://science.sciencemag.org/content/372/6543/eabc7531')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements','https://science.sciencemag.org/content/372/6543/eabc7531')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<!--/.center-->
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/aacr.png">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>AACR-MPM Transformative Cancer Research</h2>
<h3>January 19th, 2021</h3>
<p>AACR and MPM Oncology Charitable Foundation announced three grants to support transformative cancer research and our lab was one of the recipients. This <a href="https://www.aacr.org/about-the-aacr/newsroom/news-releases/aacr-and-mpm-oncology-charitable-foundation-announce-three-grants-to-support-transformative-cancer-research/">funding mechanism</a> is an innovative partnership between the American Association for Cancer Research (AACR) and the UBS Oncology Impact Fund (OIF) managed by MPM Capital. With support from this grant, we will expand on our research on the role of our newly discovered <a href="https://www.nature.com/articles/s41591-018-0230-4"> orpan non-coding RNAs</a> to serve as building blocks for cancer-engineered regulatory programs.</p>
</div>
</div>
</div>
</div>
<!--/.center-->
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/GCNN.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>An integrative in vitro and in silico screen reveals a molecular basis for sex differences in mortality from SARS-CoV-2</h2>
<h3>May 12th, 2020</h3>
<p>With widespread societal and economical devastation, the new coronovirus pandemic has deeply reshaped our approach to life and how we do science. The heterogeneity of patient response to this virus remains a baffling mystery that complicates clinical response. Age was determined as a clear risk factor; however, it was soon discovered that risk of mortality from this infection is substantially higher in men. Recently, members of the <a href="https://fattahilab.ucsf.edu/">Fattahi lab</a> carried out a systematic in vitro screening of stem-cell derived cardiomyocites to identify regulators of ACE2 expression, an enzyme that acts as the receptor for SARS-CoV-2. We levergaed this valuable screen to train a deep learning model that is capable of large-scale in silico screens to identify other compounds that can target ACE2 expression. Systematic analyses of these hit compounds revealed Andregen signaling as a key pathway involved in ACE2 expression. Confirmatory analyses in the UK Biobank dataset revealed a consistent association between androgen levels and COVID-19 risk. This work is published as a research article in <a href="https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(20)30547-6">Cell Stem Cell</a> and an eariler manuscript describing these results was published as a <a href="https://www.biorxiv.org/content/10.1101/2020.05.12.091082v1">preprint</a>. You can also read an <a href="https://www.ucsf.edu/magazine/frontliner-fattahi">interview</a> with Dr. Faranak Fattahi putting some of these findings in context.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men','https://www.biorxiv.org/content/10.1101/2020.05.12.091082v1')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men','https://www.biorxiv.org/content/10.1101/2020.05.12.091082v1')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men','https://www.biorxiv.org/content/10.1101/2020.05.12.091082v1')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<!--/.center-->
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/PRADA.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>PRADA, a customized Lasso regression model, reveals RBMS1 as a suppressor of metastasis in colon cancer</h2>
<h3>April 27th, 2020</h3>
<p>Identifying master regulators that drive pathological gene expression is a key challenge in precision oncology. Here, we have developed an analytical framework, named PRADA, that identifies oncogenic RNA-binding proteins through the systematic detection of coordinated changes in their target regulons. Application of this approach to data collected from clinical samples, patient-derived xenografts, and cell line models of colon cancer metastasis revealed the RNA-binding protein RBMS1 as a suppressor of colon cancer progression. We observed that silencing RBMS1 results in increased metastatic capacity in xenograft mouse models, and that restoring its expression blunts metastatic liver colonization. We have found that RBMS1 functions as a post-transcriptional regulator of RNA stability by directly binding its target mRNAs. Together, our findings establish a role for RBMS1 as a previously unknown regulator of RNA stability and as a suppressor of colon cancer metastasis with clinical utility for risk stratification of patients. We recently reported these findings in the journal <a href="https://cancerdiscovery.aacrjournals.org/content/early/2020/06/06/2159-8290.CD-19-1375">Cancer Discovery</a>. You can also read the <a href="https://cancerdiscovery.aacrjournals.org/content/10/9/1261">commentary</a> graciously written by Dr. Hannah Carter for this work in the same issue.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('RBMS1 suppresses colon cancer metastasis through targeted stabilization of its mRNA regulon','https://cancerdiscovery.aacrjournals.org/content/early/2020/06/06/2159-8290.CD-19-1375')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('RBMS1 suppresses colon cancer metastasis through targeted stabilization of its mRNA regulon','https://cancerdiscovery.aacrjournals.org/content/early/2020/06/06/2159-8290.CD-19-1375')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('RBMS1 suppresses colon cancer metastasis through targeted stabilization of its mRNA regulon','https://cancerdiscovery.aacrjournals.org/content/early/2020/06/06/2159-8290.CD-19-1375')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<!--/.center-->
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/tarbp2_molcell.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>Nuclear TARBP2 as a regulator of RNA stability</h2>
<h3>September 5th, 2019</h3>
<p>In our most recent paper, we have reported the functional dissection of a previously unknown pathway of RNA decay. This study was a follow-up to our discvoery of TARBP2 as a promoter of breast cancer metastasis (<a href="http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13466.html">see here</a>). In this collaborative work, we systematically dissected the molecular mechanism through which TARBP2 regulates the expression and stability of its target regulon. Based on our model, TARBP2 binds target pre-mRNAs co-transcriptionally and recruits the RNA methylation machinery to add m6A marks. RNA methylation, in turn, influences the binding patterns of splicing factors such as SRSF1 and diminishes efficient splicing of introns. Through its interaction with components of the nuclear surveillance machinery, TARBP2 delivers these mis-spliced products to the exosome complex for degradation. Finally, we also showed that TARBP2 not only promotes breast cancer metastasis, but also acts as an oncogene in lung cancer cells. See our published work <a href="https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30434-4">here</a>.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay','https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30434-4')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay','https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30434-4')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('CNuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay','https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30434-4')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<!--/.center-->
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/T3p.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>Introducing Orphan Non-coding RNAs (oncRNAs)</h2>
<h3>November 5th, 2018</h3>
<p>We have recently annotated a new class of small RNAs, which we have named oncRNAs. These are largely absent in normal cells but emerge in cancer cells as a result of cellular transformation. We have demonstrated that cancer cells can "adopt" these orphan RNAs to carry out new functions relevant to the progression of the disease. Another benefit of oncRNAs became apparent once we realized that a large fraction of oncRNAs are released by cancer cells in exosomes. We think that since every tumor can be assigned a digital oncRNA barcode, i.e. a profile of oncRNA presence/absence, finding evidence of this barcode outside the cell can point to the existence of an underlying cancer cell from which these RNAs originate. You can read the paper in November's issue of <a href="https://www.nature.com/articles/s41591-018-0230-4">Nature Medicine</a>. You can also read a new release by UCSF on <a href="https://www.ucsf.edu/news/2018/11/412276/orphan-rnas-make-cancer-deadlier-potentially-easier-diagnose">our work</a>.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('Cancer cells exploit an orphan RNA to drive metastatic progression','https://www.nature.com/articles/s41591-018-0230-4')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('Cancer cells exploit an orphan RNA to drive metastatic progression','https://www.nature.com/articles/s41591-018-0230-4')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('Cancer cells exploit an orphan RNA to drive metastatic progression','https://www.nature.com/articles/s41591-018-0230-4')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
<!--/.center-->
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/scientist.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>Opinion: Broken Promises Caused by the Travel Ban</h2>
<h3>June 28th, 2018</h3>
<p>Read Hani's opinion piece on the impact of the travel ban on students and scholars, and the scientific community published in <a href="https://www.the-scientist.com/news-opinion/opinion--broken-promises-caused-by-the-travel-ban-64392">the Scientistl</a>. You can also read an interview by a number of UCSF faculty with the <a href="https://www.washingtonpost.com/news/speaking-of-science/wp/2018/07/03/scientists-respond-to-court-ruling-on-travel-ban-with-fear-and-frustration/?tid=ss_tw&utm_term=.6c9d66ee9920">Washington Post</a> on this issue.</p>
</div>
</div>
</div>
</div
<!--/.center-->
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/aaas.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>The AAAS Martin And Rose Wachtel Cancer Research Award</h2>
<h3>July 28th, 2017</h3>
<p>Hani Goodarzi was named the recipient of the AAAS Martin And Rose Wachtel Cancer Research Award. The annual AAAS Martin and Rose Wachtel Cancer Research Award recognizes early-career scientists who have already made outstanding contributions to the field of cancer research. See the anouncement <a href="https://www.aaas.org/news/multidisciplinary-cancer-researcher-wins-wachtel-award">here</a>. The prize was awarded in July at National Institute of Health (NCI) (see here for the <a href="https://nihrecord.nih.gov/newsletters/2017/09_22_2017/story4.htm">NIH record</a> of the talk).</p>
</div>
</div>
</div>
</div>
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/aacr.png">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>AACR NextGen Stars</h2>
<h3>April 5th, 2017</h3>
<p>Hani Goodarzi was awarded the AACR-Takeda Oncology NextGen Grant for Transformative Research by the American Association for Cancer Research (AACR). This award represents the AACR’s flagship funding initiative to stimulate highly innovative research from young investigators. This grant mechanism is intended to promote and support creative, paradigm-shifting cancer research that may not be funded through conventional channels.</p>
</div>
</div>
</div>
</div>
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/skf.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>Sidney Kimmel Foundation</h2>
<h3>March 18th, 2017</h3>
<p>Hani Goodarzi was named a Kimmel Scholar by the Sidney Kimmel Foundation. Begun in 1997, the Kimmel Scholars Program was designed to jump-start the careers of the most promising and creative researchers and physician-scientists seeking solutions to the riddle of cancer. Over the two decades, the Program has contributed some of the most successful members to the next generation, or maybe two, of the nation’s leading cancer researchers.</p>
</div>
</div>
</div>
</div>
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/nsf.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>NSF Graduate Research Fellowship Program</h2>
<h3>March 17th, 2017</h3>
<p>Congratulations to our 2016 rotation students. Johnny Yu (BMS) and Bushra Bibi (Tetrad) for receiving the fellowship and Myles Hochman (Tetrad) for honorable mention. The NSF Graduate Research Fellowship Program recognizes and supports outstanding graduate students in NSF-supported science, technology, engineering, and mathematics disciplines who are pursuing research-based Master's and doctoral degrees at accredited United States institutions.</p>
</div>
</div>
</div>
</div>
<div class="row box-shadow">
<div class="col-xs-12 col-sm-12 col-md-12">
<div class="row thumbnail row-sm-flex-center">
<div class="col-xs-4 col-sm-4 col-md-3">
<img class="img-responsive" src="images/img/tRNA.jpg">
</div>
<div class="col-xs-8 col-sm-8 col-md-9">
<h2>tRNAs as global regulators of gene expression</h2>
<h3>June 7th, 2016</h3>
<p>Transfer-RNAs are tranditionally viewed as a static component of the protein synthesis machinery. Recently, several studies have raised the possibility that tRNAs are more dynamic and can support different cellular states and phenotypes. Although generally debated, some evidence has emerged that tRNA levels in the cell imapct the gene expression landscape in the cell. In a recent study, we demonstrated that the tRNA landscape is drastically modified in highly metastatic cells and that these modulations drive the expression of key promoters of metastasis. These results were published in <a href="http://www.cell.com/cell/fulltext/S0092-8674(16)30649-3">Cell</a>. You can also read a short <a href="http://www.cell.com/cell/fulltext/S0092-8674(16)30670-5">preview</a> about this study.</p>
<a class="btn btn-social-icon btn-twitter" href="https://twitter.com/share?url=<;url>" onclick="return tws_click('Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression','http://www.cell.com/cell/fulltext/S0092-8674(16)30649-3')" target="_blank" style="text-decoration:none;"><i class="fa fa-twitter"></i></a>
<a class="btn btn-social-icon btn-facebook" href="http://www.facebook.com/share.php?u=<;url>" onclick="return fbs_click('Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression','http://www.cell.com/cell/fulltext/S0092-8674(16)30649-3')" target="_blank" style="text-decoration:none;"><i class="fa fa-facebook"></i></a>
<a class="btn btn-social-icon btn-linkedin" href="http://www.linkedin.com/shareArticle?mini=true&url=<;url>" onclick="return ins_click('Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression','http://www.cell.com/cell/fulltext/S0092-8674(16)30649-3')" target="_blank" style="text-decoration:none;"><i class="fa fa-linkedin"></i></a>
</div>
</div>
</div>
</div>
</div>
<!--/.container-->
</section>
<!--/#recent-works-->
<section id="get-started">
<div class="container">
<div class="row">
<div class="col-sm-12">
<h2>Want to discuss a project?</h2>
<p>Do you have ideas that you think may help us do a better science? Then...</p>
<a href="contact-us.html" class="btn btn-primary">Contact us</a> </div>
</div>
</div>
<!--/.container-->
</section>
<!--/#get-started-->
<div class="color-border"> </div>
<footer id="footer">
<div class="container">
<div class="row">
<div class="col-sm-6">Copyright © 2015 Goodarzi Lab.
<br /><small>Design by <a href="http://www.templategarden.com" rel="nofollow">TemplateGarden</a></small>
</div>
<div class="col-sm-6">
<div class="follow-us"> <a class="fa fa-twitter social-icon" href="https://twitter.com/genophoria"></a> <a class="fa fa-linkedin social-icon" href="https://www.linkedin.com/in/hgoodarzi/"></a> </div>
</div>
</div>
</div>
</footer>
<!--/#footer-->
<script src="js/jquery.js"></script>
<script src="js/bootstrap.min.js"></script>
<script src="js/jquery.prettyPhoto.js"></script>
<script src="js/jquery.isotope.min.js"></script>
<script src="js/main.js"></script>
<script>function fbs_click(title, url) {window.open('http://www.facebook.com/sharer.php?u='+encodeURIComponent(url)+'&t='+encodeURIComponent(title),'sharer','toolbar=0,status=0,width=626,height=436');return false;}</script>
<script>function tws_click(title, url) {window.open('https://twitter.com/share?url='+encodeURIComponent(url)+'&text='+encodeURIComponent(title),'sharer','toolbar=0,status=0,width=626,height=436');return false;}</script>
<script>function gps_click(url) {window.open('https://plus.google.com/share?url='+encodeURIComponent(url),'sharer','toolbar=0,status=0,width=626,height=436');return false;}</script>
<script>function ins_click(title, url) {window.open('http://www.linkedin.com/shareArticle?mini=true&url='+encodeURIComponent(url)+'&title='+encodeURIComponent(title),'sharer','toolbar=0,status=0,width=626,height=436');return false;}</script>
</body>
</html>