diff --git a/CHANGELOG.md b/CHANGELOG.md
index e67270fd9d..42e4ffa46d 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -16,6 +16,7 @@
   - `InvalidOperationException` potentially thrown during a race condition, especially in concurrent high-volume logging scenarios ([#4428](https://github.com/getsentry/sentry-dotnet/pull/4428))
 - Blocking calls are no longer treated as unhandled crashes ([#4458](https://github.com/getsentry/sentry-dotnet/pull/4458))
 - Only apply Session Replay masks to specific control types when necessary to avoid performance issues in MAUI apps with complex UIs ([#4445](https://github.com/getsentry/sentry-dotnet/pull/4445))
+- Ensure profiling is disabled in Blazor WebAssembly ([#4507](https://github.com/getsentry/sentry-dotnet/pull/4507))
 
 ### Dependencies
 
diff --git a/src/Sentry.AspNetCore.Blazor.WebAssembly/Sentry.AspNetCore.Blazor.WebAssembly.csproj b/src/Sentry.AspNetCore.Blazor.WebAssembly/Sentry.AspNetCore.Blazor.WebAssembly.csproj
index 4ff5701fa0..263ab88be4 100644
--- a/src/Sentry.AspNetCore.Blazor.WebAssembly/Sentry.AspNetCore.Blazor.WebAssembly.csproj
+++ b/src/Sentry.AspNetCore.Blazor.WebAssembly/Sentry.AspNetCore.Blazor.WebAssembly.csproj
@@ -7,6 +7,7 @@
 
   <ItemGroup>
     <ProjectReference Include="..\Sentry.Extensions.Logging\Sentry.Extensions.Logging.csproj" />
+    <ProjectReference Include="..\Sentry.Profiling\Sentry.Profiling.csproj" />
     <ProjectReference Include="..\Sentry\Sentry.csproj" />
   </ItemGroup>
 
diff --git a/src/Sentry.AspNetCore.Blazor.WebAssembly/WebAssemblyHostBuilderExtensions.cs b/src/Sentry.AspNetCore.Blazor.WebAssembly/WebAssemblyHostBuilderExtensions.cs
index ca208e0280..db1febde85 100644
--- a/src/Sentry.AspNetCore.Blazor.WebAssembly/WebAssemblyHostBuilderExtensions.cs
+++ b/src/Sentry.AspNetCore.Blazor.WebAssembly/WebAssemblyHostBuilderExtensions.cs
@@ -1,6 +1,8 @@
 using Microsoft.Extensions.Logging;
 using Sentry;
+using Sentry.Extensibility;
 using Sentry.Extensions.Logging;
+using Sentry.Profiling;
 
 // ReSharper disable once CheckNamespace - Discoverability
 namespace Microsoft.AspNetCore.Components.WebAssembly.Hosting;
@@ -28,10 +30,27 @@ public static WebAssemblyHostBuilder UseSentry(this WebAssemblyHostBuilder build
             blazorOptions.RequestBodyCompressionLevel = CompressionLevel.NoCompression;
             // Since the WebAssemblyHost is a client-side application
             blazorOptions.IsGlobalModeEnabled = true;
+            // If profiling enabled, disable it.
+            RemoveBlazorProfilingIntegration(blazorOptions);
         });
 
         return builder;
     }
+
+    private static void RemoveBlazorProfilingIntegration(SentryBlazorOptions options)
+    {
+        if (!options.IsProfilingEnabled)
+        {
+            return;
+        }
+
+        options.SetupLogging();
+        options.LogDebug("Detected Sentry profiling initialization in Blazor WebAssembly. " +
+                         "Sentry does not support Blazor WebAssembly profiling. Removing profiling integration. " +
+                         "Check https://github.com/getsentry/sentry-dotnet/issues/4506 for more information.");
+        // Ensure project doesn't have Profiling Integration
+        options.RemoveIntegration<ProfilingIntegration>();
+    }
 }
 
 /// <summary>
diff --git a/src/Sentry/Sentry.csproj b/src/Sentry/Sentry.csproj
index f00de450ff..604f8edaae 100644
--- a/src/Sentry/Sentry.csproj
+++ b/src/Sentry/Sentry.csproj
@@ -13,7 +13,7 @@
     <TargetFrameworks Condition="'$(NO_IOS)' == '' And $([MSBuild]::IsOSPlatform('OSX'))">$(TargetFrameworks);net9.0-ios18.0;net8.0-ios17.0</TargetFrameworks>
     <TargetFrameworks Condition="'$(NO_MACCATALYST)' == '' And $([MSBuild]::IsOSPlatform('OSX'))">$(TargetFrameworks);net9.0-maccatalyst18.0;net8.0-maccatalyst17.0</TargetFrameworks>
   </PropertyGroup>
-  
+
   <!-- Platform-specific props included here -->
   <Import Project="Platforms\Android\Sentry.Android.props" Condition="'$(TargetPlatformIdentifier)' == 'android'" />
   <Import Project="Platforms\Cocoa\Sentry.Cocoa.props" Condition="'$(TargetPlatformIdentifier)' == 'ios' Or '$(TargetPlatformIdentifier)' == 'maccatalyst'" />
@@ -148,6 +148,7 @@
     <InternalsVisibleTo Include="Sentry.AspNetCore.Grpc.Tests" PublicKey="$(SentryPublicKey)" />
     <InternalsVisibleTo Include="Sentry.AspNetCore.Tests" PublicKey="$(SentryPublicKey)" />
     <InternalsVisibleTo Include="Sentry.AspNetCore.TestUtils" PublicKey="$(SentryPublicKey)" />
+    <InternalsVisibleTo Include="Sentry.AspNetCore.Blazor.WebAssembly" PublicKey="$(SentryPublicKey)" />
     <InternalsVisibleTo Include="Sentry.Azure.Functions.Worker" PublicKey="$(SentryPublicKey)" />
     <InternalsVisibleTo Include="Sentry.Azure.Functions.Worker.Tests" PublicKey="$(SentryPublicKey)" />
     <InternalsVisibleTo Include="Sentry.Benchmarks" PublicKey="$(SentryPublicKey)" />