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Week 19

Single-cell RNAseq - day 2

Presenter: Dr. Jennifer Foltz

Homework Assignments

This homework builds on what we learned last week. To complete the homework assignment you will need to have R/Rstudio installed. You will not be able to open the Rmarkdown homeowrk file without this installation. In addition, we recommend installation of the following packages within R/Rstudio to do the homework for week 18 and week 19. (note: RStudio may prompt you to install these when you open the Rmarkdown file)

  • Seurat
  • RMarkdown
  • ggplot2
  • cowplot
  • dplyr
  • Matrix
  • viridis
  • NEW for day 2: harmony
  • NEW for day 2: SeuratWrappers
  • NEW for day 2: scCustomize

To run the day 2 Rmarkdown homework file, you will use the same dataset as last week- see last week's instructions. Make sure to install the 3 new packages listed above.

Use the #bfx-workshop slack channel to ask questions.

There are several questions in this week's notebook:

  • Based on the above, how many PCs do you think are informative?
  • Now we cluster using both the RNA and protein data. How does it compare to RNA only?

For-credit-students: send a brief answer to each question to John as proof of completion.