diff --git a/packages/react-dom/src/__tests__/ReactDOMFiber-test.js b/packages/react-dom/src/__tests__/ReactDOMFiber-test.js
index 7a44cc813656ee..425e28ec0f78f8 100644
--- a/packages/react-dom/src/__tests__/ReactDOMFiber-test.js
+++ b/packages/react-dom/src/__tests__/ReactDOMFiber-test.js
@@ -1031,6 +1031,17 @@ describe('ReactDOMFiber', () => {
     const handlerA = () => ops.push('A');
     const handlerB = () => ops.push('B');
 
+    function click() {
+      const event = new MouseEvent('click', {
+        bubbles: true,
+        cancelable: true,
+      });
+      Object.defineProperty(event, 'timeStamp', {
+        value: 0,
+      });
+      node.dispatchEvent(event);
+    }
+
     class Example extends React.Component {
       state = {flip: false, count: 0};
       flip() {
@@ -1064,7 +1075,7 @@ describe('ReactDOMFiber', () => {
     const node = container.firstChild;
     expect(node.tagName).toEqual('DIV');
 
-    node.click();
+    click();
 
     expect(ops).toEqual(['A']);
     ops = [];
diff --git a/packages/react-dom/src/events/ReactDOMEventListener.js b/packages/react-dom/src/events/ReactDOMEventListener.js
index 5066cc005a0c64..6f0b981ab95df9 100644
--- a/packages/react-dom/src/events/ReactDOMEventListener.js
+++ b/packages/react-dom/src/events/ReactDOMEventListener.js
@@ -130,7 +130,7 @@ function dispatchDiscreteEvent(
     // flushed for this event and we don't need to do it again.
     (eventSystemFlags & IS_LEGACY_FB_SUPPORT_MODE) === 0
   ) {
-    flushDiscreteUpdatesIfNeeded();
+    flushDiscreteUpdatesIfNeeded(nativeEvent.timeStamp);
   }
   discreteUpdates(
     dispatchEvent,
diff --git a/packages/react-dom/src/events/ReactDOMUpdateBatching.js b/packages/react-dom/src/events/ReactDOMUpdateBatching.js
index 68d33a8c65a698..ca0e9c5b2a49c4 100644
--- a/packages/react-dom/src/events/ReactDOMUpdateBatching.js
+++ b/packages/react-dom/src/events/ReactDOMUpdateBatching.js
@@ -87,8 +87,25 @@ export function discreteUpdates(fn, a, b, c, d) {
   }
 }
 
-export function flushDiscreteUpdatesIfNeeded() {
-  if (!isInsideEventHandler) {
+let lastFlushedEventTimeStamp = 0;
+export function flushDiscreteUpdatesIfNeeded(timeStamp: number) {
+  // event.timeStamp isn't overly reliable due to inconsistencies in
+  // how different browsers have historically provided the time stamp.
+  // Some browsers provide high-resolution time stamps for all events,
+  // some provide low-resolution time stamps for all events. FF < 52
+  // even mixes both time stamps together. Some browsers even report
+  // negative time stamps or time stamps that are 0 (iOS9) in some cases.
+  // Given we are only comparing two time stamps with equality (!==),
+  // we are safe from the resolution differences. If the time stamp is 0
+  // we bail-out of preventing the flush, which can affect semantics,
+  // such as if an earlier flush removes or adds event listeners that
+  // are fired in the subsequent flush. However, this is the same
+  // behaviour as we had before this change, so the risks are low.
+  if (
+    !isInsideEventHandler &&
+    (timeStamp === 0 || lastFlushedEventTimeStamp !== timeStamp)
+  ) {
+    lastFlushedEventTimeStamp = timeStamp;
     flushDiscreteUpdatesImpl();
   }
 }
diff --git a/packages/react-dom/src/events/plugins/__tests__/ModernSimpleEventPlugin-test.js b/packages/react-dom/src/events/plugins/__tests__/ModernSimpleEventPlugin-test.js
index 0063fa417e7f41..4ed062404e52f6 100644
--- a/packages/react-dom/src/events/plugins/__tests__/ModernSimpleEventPlugin-test.js
+++ b/packages/react-dom/src/events/plugins/__tests__/ModernSimpleEventPlugin-test.js
@@ -275,9 +275,14 @@ describe('SimpleEventPlugin', function() {
       expect(Scheduler).toFlushAndYield(['render button: enabled']);
 
       function click() {
-        button.dispatchEvent(
-          new MouseEvent('click', {bubbles: true, cancelable: true}),
-        );
+        const event = new MouseEvent('click', {
+          bubbles: true,
+          cancelable: true,
+        });
+        Object.defineProperty(event, 'timeStamp', {
+          value: 0,
+        });
+        button.dispatchEvent(event);
       }
 
       // Click the button to trigger the side-effect
@@ -340,9 +345,14 @@ describe('SimpleEventPlugin', function() {
       expect(button.textContent).toEqual('Count: 0');
 
       function click() {
-        button.dispatchEvent(
-          new MouseEvent('click', {bubbles: true, cancelable: true}),
-        );
+        const event = new MouseEvent('click', {
+          bubbles: true,
+          cancelable: true,
+        });
+        Object.defineProperty(event, 'timeStamp', {
+          value: 0,
+        });
+        button.dispatchEvent(event);
       }
 
       // Click the button a single time
@@ -421,9 +431,14 @@ describe('SimpleEventPlugin', function() {
       expect(button.textContent).toEqual('High-pri count: 0, Low-pri count: 0');
 
       function click() {
-        button.dispatchEvent(
-          new MouseEvent('click', {bubbles: true, cancelable: true}),
-        );
+        const event = new MouseEvent('click', {
+          bubbles: true,
+          cancelable: true,
+        });
+        Object.defineProperty(event, 'timeStamp', {
+          value: 0,
+        });
+        button.dispatchEvent(event);
       }
 
       // Click the button a single time