diff --git a/pyproject.toml b/pyproject.toml
index fdf9980506..36bfe1f054 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -2,7 +2,7 @@
 requires = [
   "marko==2.1.2",
   "ruamel.yaml==0.18.10",
-  "setuptools==78.0.2",
+  "setuptools==78.1.0",
   "wheel==0.45.1",
 ]
 
@@ -25,7 +25,7 @@ dependencies = [
   "pycryptodome==3.22.0",
   "remerkleable==0.1.28",
   "ruamel.yaml==0.18.10",
-  "setuptools==78.0.2",
+  "setuptools==78.1.0",
   "trie==3.1.0",
 ]
 
@@ -37,7 +37,7 @@ test = [
 ]
 lint = [
   "codespell==2.4.1",
-  "flake8==7.1.2",
+  "flake8==7.2.0",
   "mypy==1.15.0",
   "pylint==3.3.6",
 ]
@@ -50,6 +50,6 @@ generator = [
 docs = [
   "mdx-truly-sane-lists==1.3",
   "mkdocs-awesome-pages-plugin==2.10.1",
-  "mkdocs-material==9.6.9",
+  "mkdocs-material==9.6.10",
   "mkdocs==1.6.1",
 ]
diff --git a/pysetup/spec_builders/phase0.py b/pysetup/spec_builders/phase0.py
index abfc8a802a..2cc44562d3 100644
--- a/pysetup/spec_builders/phase0.py
+++ b/pysetup/spec_builders/phase0.py
@@ -49,7 +49,6 @@ def cache_this(key_fn, value_fn, lru_size):  # type: ignore
 
     def wrapper(*args, **kw):  # type: ignore
         key = key_fn(*args, **kw)
-        nonlocal cache_dict
         if key not in cache_dict:
             cache_dict[key] = value_fn(*args, **kw)
         return cache_dict[key]
diff --git a/tests/core/pyspec/eth2spec/test/bellatrix/block_processing/test_process_execution_payload.py b/tests/core/pyspec/eth2spec/test/bellatrix/block_processing/test_process_execution_payload.py
index 934c94c484..3000bc4564 100644
--- a/tests/core/pyspec/eth2spec/test/bellatrix/block_processing/test_process_execution_payload.py
+++ b/tests/core/pyspec/eth2spec/test/bellatrix/block_processing/test_process_execution_payload.py
@@ -64,7 +64,7 @@ def run_execution_payload_processing(spec, state, execution_payload, valid=True,
 
     class TestEngine(spec.NoopExecutionEngine):
         def verify_and_notify_new_payload(self, new_payload_request) -> bool:
-            nonlocal called_new_block, execution_valid
+            nonlocal called_new_block
             called_new_block = True
             assert new_payload_request.execution_payload == execution_payload
             return execution_valid
diff --git a/tests/core/pyspec/eth2spec/test/context.py b/tests/core/pyspec/eth2spec/test/context.py
index d80966381f..f9f195f39d 100644
--- a/tests/core/pyspec/eth2spec/test/context.py
+++ b/tests/core/pyspec/eth2spec/test/context.py
@@ -67,7 +67,6 @@ def deco(fn):
         def entry(*args, spec: Spec, phases: SpecForks, **kw):
             # make a key for the state, unique to the fork + config (incl preset choice) and balances/activations
             key = (spec.fork, spec.config.__hash__(), spec.__file__, balances_fn, threshold_fn)
-            global _custom_state_cache_dict
             if key not in _custom_state_cache_dict:
                 state = _prepare_state(balances_fn, threshold_fn, spec, phases)
                 _custom_state_cache_dict[key] = state.get_backing()
diff --git a/tests/core/pyspec/eth2spec/test/deneb/block_processing/test_process_execution_payload.py b/tests/core/pyspec/eth2spec/test/deneb/block_processing/test_process_execution_payload.py
index 7266de8ae4..e2b34157bd 100644
--- a/tests/core/pyspec/eth2spec/test/deneb/block_processing/test_process_execution_payload.py
+++ b/tests/core/pyspec/eth2spec/test/deneb/block_processing/test_process_execution_payload.py
@@ -72,7 +72,7 @@ def run_execution_payload_processing(spec, state, execution_payload, blob_kzg_co
 
     class TestEngine(spec.NoopExecutionEngine):
         def verify_and_notify_new_payload(self, new_payload_request) -> bool:
-            nonlocal called_new_block, execution_valid
+            nonlocal called_new_block
             called_new_block = True
             assert new_payload_request.execution_payload == execution_payload
             return execution_valid
diff --git a/tests/core/pyspec/eth2spec/test/helpers/attestations.py b/tests/core/pyspec/eth2spec/test/helpers/attestations.py
index b31fd36a3e..094cc803b8 100644
--- a/tests/core/pyspec/eth2spec/test/helpers/attestations.py
+++ b/tests/core/pyspec/eth2spec/test/helpers/attestations.py
@@ -422,7 +422,6 @@ def cached_prepare_state_with_attestations(spec, state):
     # prepare it with attestations, and put it in the LRU.
     # The input state is likely already cached, so the hash-tree-root does not affect speed.
     key = (spec.fork, state.hash_tree_root())
-    global _prep_state_cache_dict
     if key not in _prep_state_cache_dict:
         prepare_state_with_attestations(spec, state)
         _prep_state_cache_dict[key] = state.get_backing()  # cache the tree structure, not the view wrapping it.
diff --git a/tests/core/pyspec/eth2spec/test/helpers/rewards.py b/tests/core/pyspec/eth2spec/test/helpers/rewards.py
index 7e08a4ad9e..31c669bc4e 100644
--- a/tests/core/pyspec/eth2spec/test/helpers/rewards.py
+++ b/tests/core/pyspec/eth2spec/test/helpers/rewards.py
@@ -300,7 +300,6 @@ def entry(*args, spec, state, **kw):
             # transition it to leak, and put it in the LRU.
             # The input state is likely already cached, so the hash-tree-root does not affect speed.
             key = (state.hash_tree_root(), spec.MIN_EPOCHS_TO_INACTIVITY_PENALTY, spec.SLOTS_PER_EPOCH, epochs)
-            global _cache_dict
             if key not in _cache_dict:
                 transition_state_to_leak(spec, state, epochs=epochs)
                 _cache_dict[key] = state.get_backing()  # cache the tree structure, not the view wrapping it.