diff --git a/op-bindings/Makefile b/op-bindings/Makefile
index 7392f37e53a02..0aa8c2707fcef 100644
--- a/op-bindings/Makefile
+++ b/op-bindings/Makefile
@@ -7,6 +7,8 @@ contracts-list := ./artifacts.json
 log-level := info
 ETHERSCAN_APIKEY_ETH ?=
 ETHERSCAN_APIKEY_OP ?=
+RPC_URL_ETH ?=
+RPC_URL_OP ?=
 
 all: version mkdir bindings
 
@@ -36,7 +38,9 @@ bindgen-generate-all:
 		--source-maps-list MIPS,PreimageOracle \
 		--forge-artifacts $(contracts-dir)/forge-artifacts \
 		--etherscan.apikey.eth $(ETHERSCAN_APIKEY_ETH) \
-		--etherscan.apikey.op $(ETHERSCAN_APIKEY_OP)
+		--etherscan.apikey.op $(ETHERSCAN_APIKEY_OP) \
+		--rpc.url.eth $(RPC_URL_ETH) \
+		--rpc.url.op $(RPC_URL_OP)
 
 bindgen-local: compile bindgen-generate-local
 
@@ -60,7 +64,9 @@ bindgen-remote:
 		--log.level $(log-level) \
 		remote \
 		--etherscan.apikey.eth $(ETHERSCAN_APIKEY_ETH) \
-		--etherscan.apikey.op $(ETHERSCAN_APIKEY_OP)
+		--etherscan.apikey.op $(ETHERSCAN_APIKEY_OP) \
+		--rpc.url.eth $(RPC_URL_ETH) \
+		--rpc.url.op $(RPC_URL_OP)
 
 mkdir:
 	mkdir -p $(pkg)
diff --git a/op-bindings/bindgen/generator_remote.go b/op-bindings/bindgen/generator_remote.go
index e059e7428fbb8..8e966e4922b3a 100644
--- a/op-bindings/bindgen/generator_remote.go
+++ b/op-bindings/bindgen/generator_remote.go
@@ -7,6 +7,7 @@ import (
 
 	"github.com/ethereum-optimism/optimism/op-bindings/etherscan"
 	"github.com/ethereum/go-ethereum/common"
+	"github.com/ethereum/go-ethereum/ethclient"
 )
 
 type bindGenGeneratorRemote struct {
@@ -15,6 +16,10 @@ type bindGenGeneratorRemote struct {
 		eth contractDataClient
 		op  contractDataClient
 	}
+	rpcClients struct {
+		eth *ethclient.Client
+		op  *ethclient.Client
+	}
 	tempArtifactsDir string
 }
 
diff --git a/op-bindings/bindgen/main.go b/op-bindings/bindgen/main.go
index eb88e571193bd..632d3be3e62fb 100644
--- a/op-bindings/bindgen/main.go
+++ b/op-bindings/bindgen/main.go
@@ -7,6 +7,7 @@ import (
 	"github.com/ethereum-optimism/optimism/op-bindings/etherscan"
 	"github.com/ethereum-optimism/optimism/op-e2e/config"
 	oplog "github.com/ethereum-optimism/optimism/op-service/log"
+	"github.com/ethereum/go-ethereum/ethclient"
 	"github.com/ethereum/go-ethereum/log"
 	"github.com/urfave/cli/v2"
 )
@@ -170,6 +171,13 @@ func parseConfigRemote(logger log.Logger, c *cli.Context) (bindGenGeneratorRemot
 
 	generator.contractDataClients.eth = etherscan.NewEthereumClient(c.String(EtherscanApiKeyEthFlagName))
 	generator.contractDataClients.op = etherscan.NewOptimismClient(c.String(EtherscanApiKeyOpFlagName))
+
+	if generator.rpcClients.eth, err = ethclient.Dial(c.String(RpcUrlEthFlagName)); err != nil {
+		return bindGenGeneratorRemote{}, fmt.Errorf("error initializing Ethereum client: %w", err)
+	}
+	if generator.rpcClients.op, err = ethclient.Dial(c.String(RpcUrlOpFlagName)); err != nil {
+		return bindGenGeneratorRemote{}, fmt.Errorf("error initializing Optimism client: %w", err)
+	}
 	return generator, nil
 }
 
@@ -221,5 +229,15 @@ func remoteFlags() []cli.Flag {
 			Usage:    "API key to make queries to Etherscan for Optimism",
 			Required: true,
 		},
+		&cli.StringFlag{
+			Name:     RpcUrlEthFlagName,
+			Usage:    "RPC URL (with API key if required) to query Ethereum",
+			Required: true,
+		},
+		&cli.StringFlag{
+			Name:     RpcUrlOpFlagName,
+			Usage:    "RPC URL (with API key if required) to query Optimism",
+			Required: true,
+		},
 	}
 }
diff --git a/op-bindings/bindgen/remote_handlers.go b/op-bindings/bindgen/remote_handlers.go
index 74a44d98bd462..a182db04200ce 100644
--- a/op-bindings/bindgen/remote_handlers.go
+++ b/op-bindings/bindgen/remote_handlers.go
@@ -10,6 +10,8 @@ import (
 	"text/template"
 
 	"github.com/ethereum-optimism/optimism/op-bindings/etherscan"
+	"github.com/ethereum/go-ethereum/common"
+	"github.com/ethereum/go-ethereum/ethclient"
 )
 
 type contractData struct {
@@ -25,6 +27,12 @@ func (generator *bindGenGeneratorRemote) standardHandler(contractMetadata *remot
 	}
 
 	contractMetadata.DeployedBin = fetchedData.deployedBin
+	if err = generator.compareDeployedBytecodeWithRpc(contractMetadata, "eth"); err != nil {
+		return err
+	}
+	if err = generator.compareDeployedBytecodeWithRpc(contractMetadata, "op"); err != nil {
+		return err
+	}
 
 	// If ABI was explicitly provided by config, don't overwrite
 	if contractMetadata.ABI == "" {
@@ -76,6 +84,12 @@ func (generator *bindGenGeneratorRemote) multiSendHandler(contractMetadata *remo
 
 	contractMetadata.ABI = fetchedData.abi
 	contractMetadata.DeployedBin = fetchedData.deployedBin
+	if err = generator.compareDeployedBytecodeWithRpc(contractMetadata, "eth"); err != nil {
+		return err
+	}
+	if err = generator.compareDeployedBytecodeWithRpc(contractMetadata, "op"); err != nil {
+		return err
+	}
 	if contractMetadata.InitBin, err = generator.removeDeploymentSalt(fetchedData.deploymentTx.Input, contractMetadata.DeploymentSalt); err != nil {
 		return err
 	}
@@ -89,6 +103,12 @@ func (generator *bindGenGeneratorRemote) senderCreatorHandler(contractMetadata *
 	if err != nil {
 		return fmt.Errorf("error fetching deployed bytecode: %w", err)
 	}
+	if err = generator.compareDeployedBytecodeWithRpc(contractMetadata, "eth"); err != nil {
+		return err
+	}
+	if err = generator.compareDeployedBytecodeWithRpc(contractMetadata, "op"); err != nil {
+		return err
+	}
 
 	// The SenderCreator contract is deployed by EntryPoint, so the transaction data
 	// from the deployment transaction is for the entire EntryPoint deployment.
@@ -221,6 +241,41 @@ func (generator *bindGenGeneratorRemote) compareBytecodeWithOp(contractMetadataE
 	return nil
 }
 
+func (generator *bindGenGeneratorRemote) compareDeployedBytecodeWithRpc(contractMetadata *remoteContractMetadata, chain string) error {
+	var client *ethclient.Client
+	switch chain {
+	case "eth":
+		client = generator.rpcClients.eth
+	case "op":
+		client = generator.rpcClients.op
+	default:
+		return fmt.Errorf("unknown chain: %s, unable to retrieve a RPC client", chain)
+	}
+
+	var deployment common.Address
+	switch chain {
+	case "eth":
+		deployment = contractMetadata.Deployments.Eth
+	case "op":
+		deployment = contractMetadata.Deployments.Op
+	default:
+		generator.logger.Warn("Unable to compare bytecode from Etherscan against RPC client, no deployment address provided for chain", "chain", chain)
+	}
+
+	if deployment != (common.Address{}) {
+		bytecode, err := client.CodeAt(context.Background(), common.HexToAddress(deployment.Hex()), nil)
+		if err != nil {
+			return fmt.Errorf("error getting deployed bytecode from RPC on chain: %s err: %w", chain, err)
+		}
+		bytecodeHex := common.Bytes2Hex(bytecode)
+		if !strings.EqualFold(strings.TrimPrefix(contractMetadata.DeployedBin, "0x"), bytecodeHex) {
+			return fmt.Errorf("%s deployment bytecode from RPC doesn't match bytecode from Etherscan. rpcBytecode: %s etherscanBytecode: %s", contractMetadata.Name, bytecodeHex, contractMetadata.DeployedBin)
+		}
+	}
+
+	return nil
+}
+
 func (generator *bindGenGeneratorRemote) writeAllOutputs(contractMetadata *remoteContractMetadata, fileTemplate string) error {
 	abiFilePath, bytecodeFilePath, err := writeContractArtifacts(
 		generator.logger, generator.tempArtifactsDir, contractMetadata.Name,