diff --git a/op-node/flags/flags.go b/op-node/flags/flags.go
index 531b4420d8c..17bbf731f82 100644
--- a/op-node/flags/flags.go
+++ b/op-node/flags/flags.go
@@ -426,6 +426,13 @@ var (
 		Destination: new(string),
 		Category:    InteropCategory,
 	}
+	InteropDependencySet = &cli.PathFlag{
+		Name:      "interop.dependency-set",
+		Usage:     "Dependency-set configuration, point at JSON file.",
+		EnvVars:   prefixEnvVars("INTEROP_DEPENDENCY_SET"),
+		TakesFile: true,
+		Category:  InteropCategory,
+	}
 
 	IgnoreMissingPectraBlobSchedule = &cli.BoolFlag{
 		Name: "ignore-missing-pectra-blob-schedule",
@@ -497,6 +504,7 @@ var optionalFlags = []cli.Flag{
 	InteropRPCAddr,
 	InteropRPCPort,
 	InteropJWTSecret,
+	InteropDependencySet,
 	IgnoreMissingPectraBlobSchedule,
 	ExperimentalOPStackAPI,
 }
diff --git a/op-node/node/config.go b/op-node/node/config.go
index e54c3f2a57c..3f10000106c 100644
--- a/op-node/node/config.go
+++ b/op-node/node/config.go
@@ -7,6 +7,7 @@ import (
 	"math"
 	"time"
 
+	"github.com/ethereum-optimism/optimism/op-node/rollup/derive"
 	"github.com/ethereum/go-ethereum/log"
 
 	altda "github.com/ethereum-optimism/optimism/op-alt-da"
@@ -31,6 +32,8 @@ type Config struct {
 
 	Rollup rollup.Config
 
+	DependencySet derive.DependencySet
+
 	// P2PSigner will be used for signing off on published content
 	// if the node is sequencing and if the p2p stack is enabled
 	P2PSigner p2p.SignerSetup
diff --git a/op-node/rollup/derive/attributes.go b/op-node/rollup/derive/attributes.go
index b90708d74fe..53ca5fab546 100644
--- a/op-node/rollup/derive/attributes.go
+++ b/op-node/rollup/derive/attributes.go
@@ -13,6 +13,11 @@ import (
 	"github.com/ethereum-optimism/optimism/op-service/predeploys"
 )
 
+type DependencySet interface {
+	// Chains returns the number of chains in the dependency set
+	Chains() []eth.ChainID
+}
+
 // L1ReceiptsFetcher fetches L1 header info and receipts for the payload attributes derivation (the info tx and deposits)
 type L1ReceiptsFetcher interface {
 	InfoByHash(ctx context.Context, hash common.Hash) (eth.BlockInfo, error)
diff --git a/op-node/service.go b/op-node/service.go
index 2938fea6861..3698b02e3f3 100644
--- a/op-node/service.go
+++ b/op-node/service.go
@@ -8,6 +8,7 @@ import (
 	"os"
 	"strings"
 
+	"github.com/ethereum-optimism/optimism/op-supervisor/supervisor/backend/depset"
 	"github.com/ethereum/go-ethereum/common"
 	"github.com/ethereum/go-ethereum/log"
 	"github.com/urfave/cli/v2"
@@ -39,6 +40,11 @@ func NewConfig(ctx *cli.Context, log log.Logger) (*node.Config, error) {
 		return nil, err
 	}
 
+	depSet, err := NewDependencySetFromCLI(ctx)
+	if err != nil {
+		return nil, err
+	}
+
 	if !ctx.Bool(flags.RollupLoadProtocolVersions.Name) {
 		log.Info("Not opted in to ProtocolVersions signal loading, disabling ProtocolVersions contract now.")
 		rollupConfig.ProtocolVersionsAddress = common.Address{}
@@ -85,6 +91,7 @@ func NewConfig(ctx *cli.Context, log log.Logger) (*node.Config, error) {
 		L1:            l1Endpoint,
 		L2:            l2Endpoint,
 		Rollup:        *rollupConfig,
+		DependencySet: depSet,
 		Driver:        *driverConfig,
 		Beacon:        NewBeaconEndpointConfig(ctx),
 		InteropConfig: NewSupervisorEndpointConfig(ctx),
@@ -285,6 +292,14 @@ func applyOverrides(ctx *cli.Context, rollupConfig *rollup.Config) {
 	}
 }
 
+func NewDependencySetFromCLI(ctx *cli.Context) (depset.DependencySet, error) {
+	if !ctx.IsSet(flags.InteropDependencySet.Name) {
+		return nil, nil
+	}
+	loader := &depset.JSONDependencySetLoader{Path: ctx.Path(flags.InteropDependencySet.Name)}
+	return loader.LoadDependencySet(ctx.Context)
+}
+
 func NewSyncConfig(ctx *cli.Context, log log.Logger) (*sync.Config, error) {
 	if ctx.IsSet(flags.L2EngineSyncEnabled.Name) && ctx.IsSet(flags.SyncModeFlag.Name) {
 		return nil, errors.New("cannot set both --l2.engine-sync and --syncmode at the same time")