diff --git a/source/common/router/config_impl.cc b/source/common/router/config_impl.cc
index b41cf84b1643a..5a8635f04e3d9 100644
--- a/source/common/router/config_impl.cc
+++ b/source/common/router/config_impl.cc
@@ -669,6 +669,10 @@ RouteEntryImplBase::RouteEntryImplBase(const VirtualHostImpl& vhost,
         "Specify only one of prefix_rewrite, regex_rewrite or path_rewrite_policy");
   }
 
+  if (!route.route().prefix_rewrite().empty() && path_matcher_ != nullptr) {
+    throw EnvoyException("Cannot use prefix_rewrite with matcher extension");
+  }
+
   if (route.route().has_regex_rewrite()) {
     auto rewrite_spec = route.route().regex_rewrite();
     regex_rewrite_ = Regex::Utility::parseRegex(rewrite_spec.pattern());
diff --git a/test/common/router/config_impl_test.cc b/test/common/router/config_impl_test.cc
index 32b77cad6900b..fd52980f39f97 100644
--- a/test/common/router/config_impl_test.cc
+++ b/test/common/router/config_impl_test.cc
@@ -8840,6 +8840,30 @@ TEST_F(RouteConfigurationV2, TemplatePatternIsDisabledWhenNotSpecifiedInRouteAct
   EXPECT_TRUE(pattern_template_policy == nullptr);
 }
 
+TEST_F(RouteConfigurationV2, RouteMatcherExtensionAndPrefixRewrite) {
+  const std::string yaml = R"EOF(
+virtual_hosts:
+  - name: path_pattern
+    domains: ["*"]
+    routes:
+      - match:
+          path_match_policy:
+            name: envoy.path.match.uri_template.uri_template_matcher
+            typed_config:
+              "@type": type.googleapis.com/envoy.extensions.path.match.uri_template.v3.UriTemplateMatchConfig
+              path_template:  "/bar/{country}/{hang}"
+        route:
+          cluster: some-cluster
+          prefix_rewrite: "!"
+
+  )EOF";
+
+  factory_context_.cluster_manager_.initializeClusters({"some-cluster"}, {});
+  EXPECT_THROW_WITH_MESSAGE(
+      TestConfigImpl config(parseRouteConfigurationFromYaml(yaml), factory_context_, true),
+      EnvoyException, "Cannot use prefix_rewrite with matcher extension");
+}
+
 TEST_F(RouteConfigurationV2, TemplatePatternIsFilledFromConfigInRouteAction) {
   const std::string yaml = R"EOF(
 virtual_hosts: