diff --git a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/alerts_table_flow/rule_exceptions/closing_all_matching_alerts.cy.ts b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/alerts_table_flow/rule_exceptions/closing_all_matching_alerts.cy.ts
index e1d06fd91e9c3..fd6fa68200f3d 100644
--- a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/alerts_table_flow/rule_exceptions/closing_all_matching_alerts.cy.ts
+++ b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/alerts_table_flow/rule_exceptions/closing_all_matching_alerts.cy.ts
@@ -48,9 +48,7 @@ const getExceptionList1 = () => ({
   list_id: 'exception_list_1',
 });
 
-// Failing: See https://github.com/elastic/kibana/issues/199905
-// Failing: See https://github.com/elastic/kibana/issues/199905
-describe.skip('Close matching Alerts ', { tags: ['@ess', '@serverless'] }, () => {
+describe('Close matching Alerts ', { tags: ['@ess', '@serverless'] }, () => {
   const ITEM_NAME = 'Sample Exception Item';
 
   beforeEach(() => {
diff --git a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/entry/match_any.cy.ts b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/entry/match_any.cy.ts
index 243e184d031f2..eba4440a778f4 100644
--- a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/entry/match_any.cy.ts
+++ b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/entry/match_any.cy.ts
@@ -45,7 +45,6 @@ describe('Exceptions match_any', { tags: ['@ess', '@serverless'] }, () => {
         index: ['auditbeat-exceptions-*'],
         enabled: false,
         query: '*',
-        from: 'now-438300h',
       })
     ).then((rule) => visitRuleDetailsPage(rule.body.id, { tab: 'rule_exceptions' }));
     cy.get(RULE_STATUS).should('have.text', '—');
diff --git a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/rule_details_flow/add_edit_exception.cy.ts b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/rule_details_flow/add_edit_exception.cy.ts
index cc32cba92aca0..c0c087d9a9c70 100644
--- a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/rule_details_flow/add_edit_exception.cy.ts
+++ b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/rule_details_flow/add_edit_exception.cy.ts
@@ -58,10 +58,7 @@ import {
 } from '../../../../../tasks/api_calls/exceptions';
 import { waitForAlertsToPopulate } from '../../../../../tasks/create_new_rule';
 
-// TODO: https://github.com/elastic/kibana/issues/161539
-// Failing: See https://github.com/elastic/kibana/issues/220822
-// Failing: See https://github.com/elastic/kibana/issues/220822
-describe.skip(
+describe(
   'Add/edit exception from rule details',
   { tags: ['@ess', '@serverless', '@skipInServerless'] },
   () => {
diff --git a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/rule_details_flow/add_edit_exception_data_view.cy.ts b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/rule_details_flow/add_edit_exception_data_view.cy.ts
index 72352c9a7b977..9709dd9eb57dc 100644
--- a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/rule_details_flow/add_edit_exception_data_view.cy.ts
+++ b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/exceptions/rule_details_flow/add_edit_exception_data_view.cy.ts
@@ -47,8 +47,7 @@ import { waitForAlertsToPopulate } from '../../../../../tasks/create_new_rule';
 
 const DATAVIEW = 'auditbeat-exceptions-*';
 
-// FLAKY: https://github.com/elastic/kibana/issues/182447
-describe.skip(
+describe(
   'Add exception using data views from rule details',
   { tags: ['@ess', '@serverless'] },
   () => {
diff --git a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/rule_creation/indicator_match_rule.cy.ts b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/rule_creation/indicator_match_rule.cy.ts
index c6e331700afc8..fa045af55f999 100644
--- a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/rule_creation/indicator_match_rule.cy.ts
+++ b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/rule_creation/indicator_match_rule.cy.ts
@@ -5,7 +5,7 @@
  * 2.0.
  */
 
-import { formatMitreAttackDescription, getHumanizedDuration } from '../../../../helpers/rules';
+import { formatMitreAttackDescription } from '../../../../helpers/rules';
 import {
   getIndexPatterns,
   getNewThreatIndicatorRule,
@@ -31,7 +31,6 @@ import {
   ABOUT_DETAILS,
   ABOUT_INVESTIGATION_NOTES,
   ABOUT_RULE_DESCRIPTION,
-  ADDITIONAL_LOOK_BACK_DETAILS,
   CUSTOM_QUERY_DETAILS,
   DEFINITION_DETAILS,
   FALSE_POSITIVES_DETAILS,
@@ -488,13 +487,6 @@ describe(
             getDetails(RUNS_EVERY_DETAILS)
               .find(INTERVAL_ABBR_VALUE)
               .should('have.text', `${rule.interval}`);
-            const humanizedDuration = getHumanizedDuration(
-              rule.from ?? 'now-6m',
-              rule.interval ?? '5m'
-            );
-            getDetails(ADDITIONAL_LOOK_BACK_DETAILS)
-              .find(INTERVAL_ABBR_VALUE)
-              .should('have.text', `${humanizedDuration}`);
           });
 
           waitForTheRuleToBeExecuted();
diff --git a/x-pack/test/security_solution_cypress/cypress/objects/rule.ts b/x-pack/test/security_solution_cypress/cypress/objects/rule.ts
index a0203cae2566f..c4cc3276ad761 100644
--- a/x-pack/test/security_solution_cypress/cypress/objects/rule.ts
+++ b/x-pack/test/security_solution_cypress/cypress/objects/rule.ts
@@ -132,7 +132,7 @@ export const getDataViewRule = (
   threat: [getMitre1(), getMitre2()],
   note: '# test markdown',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   ...rewrites,
 });
@@ -153,7 +153,7 @@ export const getNewRule = (
   threat: [getMitre1(), getMitre2()],
   note: '# test markdown',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   ...rewrites,
 });
@@ -168,7 +168,7 @@ export const getSavedQueryRule = (
   name: 'New Rule Test',
   description: 'The new rule description.',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   severity: 'low',
   risk_score: 21,
   ...rewrites,
@@ -183,7 +183,7 @@ export const getSimpleCustomQueryRule = (
   name: 'New Rule Test',
   description: 'The new rule description.',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   severity: 'low',
   risk_score: 21,
   ...rewrites,
@@ -205,7 +205,7 @@ export const getBuildingBlockRule = (
   threat: [getMitre1(), getMitre2()],
   note: '# test markdown',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   building_block_type: 'default',
   ...rewrites,
@@ -227,7 +227,7 @@ export const getUnmappedRule = (
   threat: [getMitre1(), getMitre2()],
   note: '# test markdown',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   ...rewrites,
 });
@@ -248,7 +248,7 @@ export const getUnmappedCCSRule = (
   threat: [getMitre1(), getMitre2()],
   note: '# test markdown',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   ...rewrites,
 });
@@ -269,7 +269,7 @@ export const getExistingRule = (
   threat: [],
   note: 'This is my note',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   // Please do not change, or if you do, needs
   // to be any number other than default value
   max_signals: 500,
@@ -303,7 +303,7 @@ export const getNewOverrideRule = (
   rule_name_override: 'agent.type',
   timestamp_override: '@timestamp',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   ...rewrites,
 });
@@ -328,7 +328,7 @@ export const getNewThresholdRule = (
     value: 1,
   },
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   ...rewrites,
 });
@@ -349,9 +349,9 @@ export const getNewTermsRule = (
   threat: [getMitre1(), getMitre2()],
   note: '# test markdown',
   new_terms_fields: ['host.name'],
-  history_window_start: 'now-51000h',
+  history_window_start: `now-${365 * 150}d`,
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   ...rewrites,
 });
@@ -375,7 +375,7 @@ export const getMachineLearningRule = (
   threat: [getMitre1()],
   note: '# test markdown',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   ...rewrites,
 });
 
@@ -396,7 +396,7 @@ export const getEqlRule = (
   threat: [getMitre1(), getMitre2()],
   note: '# test markdown',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   ...rewrites,
 });
@@ -417,7 +417,7 @@ export const getEsqlRule = (
   threat: [getMitre1(), getMitre2()],
   note: '# test markdown',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   ...rewrites,
 });
@@ -439,7 +439,7 @@ export const getCCSEqlRule = (
   threat: [getMitre1(), getMitre2()],
   note: '# test markdown',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   ...rewrites,
 });
@@ -464,7 +464,7 @@ export const getEqlSequenceRule = (
   threat: [getMitre1(), getMitre2()],
   note: '# test markdown',
   interval: '100m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   ...rewrites,
 });
@@ -487,7 +487,7 @@ export const getNewThreatIndicatorRule = (
   threat: [getMitre1(), getMitre2()],
   note: '# test markdown',
   interval: '100m',
-  from: 'now-50000h',
+  from: '2000-01-01T00:00:00.000Z',
   threat_index: ['filebeat-*'],
   threat_mapping: [
     {
@@ -673,7 +673,7 @@ export const getEndpointRule = (): QueryRuleCreateProps => ({
   severity: 'high',
   risk_score: 17,
   interval: '1m',
-  from: 'now-50000h',
+  from: '1900-01-01T00:00:00.000Z',
   max_signals: 100,
   exceptions_list: [
     {