diff --git a/x-pack/plugins/security_solution/public/common/components/toolbar/bulk_actions/use_bulk_alert_assignees_items.test.tsx b/x-pack/plugins/security_solution/public/common/components/toolbar/bulk_actions/use_bulk_alert_assignees_items.test.tsx
index f3269fceb2a64..82e9b062d9a7d 100644
--- a/x-pack/plugins/security_solution/public/common/components/toolbar/bulk_actions/use_bulk_alert_assignees_items.test.tsx
+++ b/x-pack/plugins/security_solution/public/common/components/toolbar/bulk_actions/use_bulk_alert_assignees_items.test.tsx
@@ -39,6 +39,7 @@ const mockUserProfiles = [
 
 const defaultProps: UseBulkAlertAssigneesItemsProps = {
   onAssigneesUpdate: () => {},
+  alertAssignments: [],
 };
 
 const mockAssigneeItems = [
@@ -170,6 +171,66 @@ describe('useBulkAlertAssigneesItems', () => {
     );
   });
 
+  it('should set unnasign alert action to disabled if no assignees exist', () => {
+    const mockSetAlertAssignees = jest.fn();
+    (useSetAlertAssignees as jest.Mock).mockReturnValue(mockSetAlertAssignees);
+    const { result } = renderHook(
+      () =>
+        useBulkAlertAssigneesItems({
+          onAssigneesUpdate: () => {},
+          alertAssignments: [],
+        }),
+      {
+        wrapper: TestProviders,
+      }
+    );
+
+    expect(
+      (
+        result.current.alertAssigneesItems[0] as unknown as {
+          disable: boolean;
+        }
+      ).disable
+    ).toBeFalsy();
+    expect(
+      (
+        result.current.alertAssigneesItems[1] as unknown as {
+          disable: boolean;
+        }
+      ).disable
+    ).toBeTruthy();
+  });
+
+  it('should set unnasign alert action to enabled if assignees exist', () => {
+    const mockSetAlertAssignees = jest.fn();
+    (useSetAlertAssignees as jest.Mock).mockReturnValue(mockSetAlertAssignees);
+    const { result } = renderHook(
+      () =>
+        useBulkAlertAssigneesItems({
+          onAssigneesUpdate: () => {},
+          alertAssignments: ['user1'],
+        }),
+      {
+        wrapper: TestProviders,
+      }
+    );
+
+    expect(
+      (
+        result.current.alertAssigneesItems[0] as unknown as {
+          disable: boolean;
+        }
+      ).disable
+    ).toBeFalsy();
+    expect(
+      (
+        result.current.alertAssigneesItems[1] as unknown as {
+          disable: boolean;
+        }
+      ).disable
+    ).toBeFalsy();
+  });
+
   it('should return 0 items for the VIEWER role', () => {
     (useAlertsPrivileges as jest.Mock).mockReturnValue({ hasIndexWrite: false });
 
diff --git a/x-pack/plugins/security_solution/public/common/components/toolbar/bulk_actions/use_bulk_alert_assignees_items.tsx b/x-pack/plugins/security_solution/public/common/components/toolbar/bulk_actions/use_bulk_alert_assignees_items.tsx
index 6e9c4cc0c871b..4c25665afa5ca 100644
--- a/x-pack/plugins/security_solution/public/common/components/toolbar/bulk_actions/use_bulk_alert_assignees_items.tsx
+++ b/x-pack/plugins/security_solution/public/common/components/toolbar/bulk_actions/use_bulk_alert_assignees_items.tsx
@@ -15,6 +15,7 @@ import type {
   RenderContentPanelProps,
 } from '@kbn/triggers-actions-ui-plugin/public/types';
 
+import { isEmpty } from 'lodash/fp';
 import { useLicense } from '../../../hooks/use_license';
 import { useAlertsPrivileges } from '../../../../detections/containers/detection_engine/alerts/use_alerts_privileges';
 import { ASSIGNEES_PANEL_WIDTH } from '../../assignees/constants';
@@ -24,6 +25,7 @@ import { useSetAlertAssignees } from './use_set_alert_assignees';
 
 export interface UseBulkAlertAssigneesItemsProps {
   onAssigneesUpdate?: () => void;
+  alertAssignments?: string[];
 }
 
 export interface UseBulkAlertAssigneesPanel {
@@ -36,6 +38,7 @@ export interface UseBulkAlertAssigneesPanel {
 
 export const useBulkAlertAssigneesItems = ({
   onAssigneesUpdate,
+  alertAssignments,
 }: UseBulkAlertAssigneesItemsProps) => {
   const isPlatinumPlus = useLicense().isPlatinumPlus();
 
@@ -89,6 +92,7 @@ export const useBulkAlertAssigneesItems = ({
               panel: 2,
               label: i18n.ALERT_ASSIGNEES_CONTEXT_MENU_ITEM_TITLE,
               disableOnQuery: true,
+              disable: false,
             },
             {
               key: 'remove-all-alert-assignees',
@@ -97,10 +101,11 @@ export const useBulkAlertAssigneesItems = ({
               label: i18n.REMOVE_ALERT_ASSIGNEES_CONTEXT_MENU_TITLE,
               disableOnQuery: true,
               onClick: onRemoveAllAssignees,
+              disable: alertAssignments ? isEmpty(alertAssignments) : false,
             },
           ]
         : [],
-    [hasIndexWrite, isPlatinumPlus, onRemoveAllAssignees]
+    [alertAssignments, hasIndexWrite, isPlatinumPlus, onRemoveAllAssignees]
   );
 
   const TitleContent = useMemo(
diff --git a/x-pack/plugins/security_solution/public/detections/components/alerts_table/timeline_actions/use_alert_assignees_actions.tsx b/x-pack/plugins/security_solution/public/detections/components/alerts_table/timeline_actions/use_alert_assignees_actions.tsx
index ff7e64a5e4dc8..84d9f8b5ca5db 100644
--- a/x-pack/plugins/security_solution/public/detections/components/alerts_table/timeline_actions/use_alert_assignees_actions.tsx
+++ b/x-pack/plugins/security_solution/public/detections/components/alerts_table/timeline_actions/use_alert_assignees_actions.tsx
@@ -31,6 +31,11 @@ export const useAlertAssigneesActions = ({
   const { hasIndexWrite } = useAlertsPrivileges();
 
   const alertId = ecsRowData._id;
+  const alertAssignments = useMemo(
+    () => ecsRowData?.kibana?.alert.workflow_assignee_ids ?? [],
+    [ecsRowData?.kibana?.alert.workflow_assignee_ids]
+  );
+
   const alertAssigneeData = useMemo(() => {
     return [
       {
@@ -39,7 +44,7 @@ export const useAlertAssigneesActions = ({
         data: [
           {
             field: ALERT_WORKFLOW_ASSIGNEE_IDS,
-            value: ecsRowData?.kibana?.alert.workflow_assignee_ids ?? [],
+            value: alertAssignments,
           },
         ],
         ecs: {
@@ -48,7 +53,7 @@ export const useAlertAssigneesActions = ({
         },
       },
     ];
-  }, [alertId, ecsRowData._index, ecsRowData?.kibana?.alert.workflow_assignee_ids]);
+  }, [alertId, ecsRowData._index, alertAssignments]);
 
   const onAssigneesUpdate = useCallback(() => {
     closePopover();
@@ -59,6 +64,7 @@ export const useAlertAssigneesActions = ({
 
   const { alertAssigneesItems, alertAssigneesPanels } = useBulkAlertAssigneesItems({
     onAssigneesUpdate,
+    alertAssignments,
   });
 
   const itemsToReturn: AlertTableContextMenuItem[] = useMemo(
@@ -69,6 +75,7 @@ export const useAlertAssigneesActions = ({
         'data-test-subj': item['data-test-subj'],
         key: item.key,
         onClick: () => item.onClick?.(alertAssigneeData, false, noop, noop, noop),
+        disabled: item.disable,
       })),
     [alertAssigneeData, alertAssigneesItems]
   );