diff --git a/.github/CODEOWNERS b/.github/CODEOWNERS
index c30906c56c2ac..f66c4921d50d4 100644
--- a/.github/CODEOWNERS
+++ b/.github/CODEOWNERS
@@ -803,7 +803,7 @@ packages/kbn-yarn-lock-validator @elastic/kibana-operations
 /x-pack/test/functional/services/uptime @elastic/uptime
 /x-pack/test/api_integration/apis/uptime @elastic/uptime
 /x-pack/plugins/observability/public/components/shared/exploratory_view @elastic/uptime
-
+/x-pack/plugins/observability/public/utils/observability_data_views @elastic/uptime
 
 # Client Side Monitoring / Uptime (lives in APM directories but owned by Uptime)
 /x-pack/plugins/apm/public/application/uxApp.tsx @elastic/uptime
diff --git a/src/plugins/data_views/common/index.ts b/src/plugins/data_views/common/index.ts
index 5f7b3a544db9d..a26895f6f9d78 100644
--- a/src/plugins/data_views/common/index.ts
+++ b/src/plugins/data_views/common/index.ts
@@ -79,3 +79,4 @@ export type {
   IndexPatternLoadExpressionFunctionDefinition,
 } from './expressions';
 export { getIndexPatternLoadMeta } from './expressions';
+export { DataViewMissingIndices } from './lib/errors';
diff --git a/x-pack/plugins/observability/public/components/shared/exploratory_view/embeddable/index.tsx b/x-pack/plugins/observability/public/components/shared/exploratory_view/embeddable/index.tsx
index 6647d2499159c..48747afe53305 100644
--- a/x-pack/plugins/observability/public/components/shared/exploratory_view/embeddable/index.tsx
+++ b/x-pack/plugins/observability/public/components/shared/exploratory_view/embeddable/index.tsx
@@ -91,6 +91,7 @@ export function getExploratoryViewEmbeddable(
     );
 
     const { dataViews, loading } = useAppDataView({
+      series,
       dataViewCache,
       dataViewsService,
       dataTypesIndexPatterns,
diff --git a/x-pack/plugins/observability/public/components/shared/exploratory_view/embeddable/use_app_data_view.ts b/x-pack/plugins/observability/public/components/shared/exploratory_view/embeddable/use_app_data_view.ts
index 768a0ac46238c..99df5a1fb6952 100644
--- a/x-pack/plugins/observability/public/components/shared/exploratory_view/embeddable/use_app_data_view.ts
+++ b/x-pack/plugins/observability/public/components/shared/exploratory_view/embeddable/use_app_data_view.ts
@@ -12,13 +12,16 @@ import type { ExploratoryEmbeddableProps, ObservabilityPublicPluginsStart } from
 import type { DataViewState } from '../hooks/use_app_data_view';
 import type { AppDataType } from '../types';
 import { ObservabilityDataViews } from '../../../../utils/observability_data_views/observability_data_views';
+import { SeriesUrl } from '../../../..';
 
 export const useAppDataView = ({
+  series,
   dataViewCache,
   seriesDataType,
   dataViewsService,
   dataTypesIndexPatterns,
 }: {
+  series: SeriesUrl;
   seriesDataType: AppDataType;
   dataViewCache: Record<string, DataView>;
   dataViewsService: ObservabilityPublicPluginsStart['dataViews'];
@@ -56,10 +59,11 @@ export const useAppDataView = ({
   );
 
   useEffect(() => {
-    if (seriesDataType) {
+    if (seriesDataType && !loading && !dataViews[seriesDataType]) {
       loadIndexPattern({ dataType: seriesDataType });
     }
-  }, [seriesDataType, loadIndexPattern]);
+    // eslint-disable-next-line react-hooks/exhaustive-deps
+  }, [seriesDataType, loadIndexPattern, JSON.stringify(series)]);
 
   return { dataViews, loading };
 };
diff --git a/x-pack/plugins/observability/public/utils/observability_data_views/observability_data_views.ts b/x-pack/plugins/observability/public/utils/observability_data_views/observability_data_views.ts
index 00552c0adc6f1..0c9ad40784ec8 100644
--- a/x-pack/plugins/observability/public/utils/observability_data_views/observability_data_views.ts
+++ b/x-pack/plugins/observability/public/utils/observability_data_views/observability_data_views.ts
@@ -13,6 +13,7 @@ import type {
   DataViewSpec,
 } from '@kbn/data-views-plugin/public';
 import { RuntimeField } from '@kbn/data-views-plugin/public';
+import { DataViewMissingIndices } from '@kbn/data-views-plugin/common';
 import { DataTypesLabels } from '../../components/shared/exploratory_view/labels';
 import { syntheticsRuntimeFields } from '../../components/shared/exploratory_view/configurations/synthetics/runtime_fields';
 import { getApmDataViewTitle } from '../../components/shared/exploratory_view/utils/utils';
@@ -121,25 +122,33 @@ export class ObservabilityDataViews {
 
     const { runtimeFields } = getFieldFormatsForApp(app);
 
-    const dataView = await this.dataViews.create(
-      {
-        title: appIndicesPattern,
-        id: getAppDataViewId(app, indices),
-        timeFieldName: '@timestamp',
-        fieldFormats: this.getFieldFormats(app),
-        name: DataTypesLabels[app],
-      },
-      false,
-      false
-    );
-
-    if (runtimeFields !== null) {
-      runtimeFields.forEach(({ name, field }) => {
-        dataView.addRuntimeField(name, field);
-      });
-    }
+    const id = getAppDataViewId(app, indices);
+
+    try {
+      const dataView = await this.dataViews.create(
+        {
+          id,
+          title: appIndicesPattern,
+          timeFieldName: '@timestamp',
+          fieldFormats: this.getFieldFormats(app),
+          name: DataTypesLabels[app],
+        },
+        false,
+        false
+      );
 
-    return dataView;
+      if (runtimeFields !== null) {
+        runtimeFields.forEach(({ name, field }) => {
+          dataView.addRuntimeField(name, field);
+        });
+      }
+
+      return dataView;
+    } catch (e) {
+      if (e instanceof DataViewMissingIndices) {
+        this.dataViews.clearInstanceCache(id);
+      }
+    }
   }
 
   async createAndSavedDataView(app: AppDataType, indices: string) {