diff --git a/x-pack/plugins/uptime/e2e/page_objects/monitor_management.tsx b/x-pack/plugins/uptime/e2e/page_objects/monitor_management.tsx
index fd877708f2bce..384242bc9af70 100644
--- a/x-pack/plugins/uptime/e2e/page_objects/monitor_management.tsx
+++ b/x-pack/plugins/uptime/e2e/page_objects/monitor_management.tsx
@@ -96,9 +96,8 @@ export function monitorManagementPageProvider({
     },
 
     async selectLocations({ locations }: { locations: string[] }) {
-      await this.clickByTestSubj('syntheticsServiceLocationsComboBox');
       for (let i = 0; i < locations.length; i++) {
-        await page.click(`text=${locations[i]}`);
+        await page.check(`text=${locations[i]}`);
       }
     },
 
diff --git a/x-pack/plugins/uptime/e2e/page_objects/utils.tsx b/x-pack/plugins/uptime/e2e/page_objects/utils.tsx
index 072d4497e856d..024609e2f69ef 100644
--- a/x-pack/plugins/uptime/e2e/page_objects/utils.tsx
+++ b/x-pack/plugins/uptime/e2e/page_objects/utils.tsx
@@ -38,6 +38,10 @@ export function utilsPageProvider({ page }: { page: Page }) {
       await page.selectOption(`[data-test-subj=${dataTestSubj}]`, value);
     },
 
+    async checkByTestSubj(dataTestSubj: string, value: string) {
+      await page.check(`[data-test-subj=${dataTestSubj}]`);
+    },
+
     async clickByTestSubj(dataTestSubj: string) {
       await page.click(`[data-test-subj=${dataTestSubj}]`);
     },
diff --git a/x-pack/plugins/uptime/public/components/monitor_management/monitor_config/locations.test.tsx b/x-pack/plugins/uptime/public/components/monitor_management/monitor_config/locations.test.tsx
index 11caf092c93c7..ccc3e7b619c68 100644
--- a/x-pack/plugins/uptime/public/components/monitor_management/monitor_config/locations.test.tsx
+++ b/x-pack/plugins/uptime/public/components/monitor_management/monitor_config/locations.test.tsx
@@ -8,8 +8,7 @@
 import React from 'react';
 import { screen } from '@testing-library/react';
 import { render } from '../../../lib/helper/rtl_helpers';
-import { ServiceLocations, LOCATIONS_LABEL } from './locations';
-import userEvent from '@testing-library/user-event';
+import { ServiceLocations } from './locations';
 
 describe('<ActionBar />', () => {
   const setLocations = jest.fn();
@@ -52,47 +51,7 @@ describe('<ActionBar />', () => {
       { state }
     );
 
-    expect(screen.getByText(LOCATIONS_LABEL)).toBeInTheDocument();
-    expect(screen.queryByText('US Central')).not.toBeInTheDocument();
-  });
-
-  it('shows location options when clicked', async () => {
-    render(
-      <ServiceLocations selectedLocations={[]} setLocations={setLocations} isInvalid={false} />,
-      { state }
-    );
-
-    userEvent.click(screen.getByRole('button'));
-
-    expect(screen.getByText('US Central')).toBeInTheDocument();
-  });
-
-  it('prevents bad inputs', async () => {
-    render(
-      <ServiceLocations selectedLocations={[]} setLocations={setLocations} isInvalid={false} />,
-      { state }
-    );
-
-    userEvent.click(screen.getByRole('button'));
-    userEvent.type(screen.getByRole('textbox'), 'fake location');
-
-    expect(screen.getByText("doesn't match any options")).toBeInTheDocument();
-
-    userEvent.keyboard(`{enter}`);
-
-    expect(screen.getByText('"fake location" is not a valid option')).toBeInTheDocument();
-  });
-
-  it('calls setLocations', async () => {
-    render(
-      <ServiceLocations selectedLocations={[]} setLocations={setLocations} isInvalid={false} />,
-      { state }
-    );
-
-    userEvent.click(screen.getByRole('button'));
-    userEvent.click(screen.getByText('US Central'));
-
-    expect(setLocations).toBeCalledWith([location]);
+    expect(screen.queryByText('US Central')).toBeInTheDocument();
   });
 
   it('shows invalid error', async () => {
diff --git a/x-pack/plugins/uptime/public/components/monitor_management/monitor_config/locations.tsx b/x-pack/plugins/uptime/public/components/monitor_management/monitor_config/locations.tsx
index 2d261e169299a..1877cc4ade126 100644
--- a/x-pack/plugins/uptime/public/components/monitor_management/monitor_config/locations.tsx
+++ b/x-pack/plugins/uptime/public/components/monitor_management/monitor_config/locations.tsx
@@ -5,10 +5,10 @@
  * 2.0.
  */
 
-import React, { useState } from 'react';
+import React, { useState, useEffect } from 'react';
 import { useSelector } from 'react-redux';
 import { i18n } from '@kbn/i18n';
-import { EuiComboBox, EuiComboBoxOptionOption, EuiFormRow } from '@elastic/eui';
+import { EuiCheckboxGroup, EuiFormRow } from '@elastic/eui';
 import { monitorManagementListSelector } from '../../../state/selectors';
 import { ServiceLocation } from '../../../../common/runtime_types';
 
@@ -20,51 +20,49 @@ interface Props {
 
 export const ServiceLocations = ({ selectedLocations, setLocations, isInvalid }: Props) => {
   const [error, setError] = useState<string | null>(null);
+  const [checkboxIdToSelectedMap, setCheckboxIdToSelectedMap] = useState<Record<string, boolean>>(
+    {}
+  );
   const { locations } = useSelector(monitorManagementListSelector);
 
-  const onLocationChange = (
-    selectedLocationOptions: Array<EuiComboBoxOptionOption<ServiceLocation>>
-  ) => {
-    setLocations(selectedLocationOptions as ServiceLocation[]);
-    setError(null);
-  };
-
-  const onSearchChange = (value: string, hasMatchingOptions?: boolean) => {
-    setError(value.length === 0 || hasMatchingOptions ? null : getInvalidOptionError(value));
-  };
-
-  const onBlur = (event: unknown) => {
-    const inputElement = (event as FocusEvent)?.target as HTMLInputElement;
-    if (inputElement) {
-      const { value } = inputElement;
-      setError(value.length === 0 ? null : getInvalidOptionError(value));
+  const onLocationChange = (optionId: string) => {
+    const isSelected = !checkboxIdToSelectedMap[optionId];
+    const location = locations.find((loc) => loc.id === optionId);
+    if (isSelected) {
+      setLocations((prevLocations) => (location ? [...prevLocations, location] : prevLocations));
+    } else {
+      setLocations((prevLocations) => [...prevLocations].filter((loc) => loc.id !== optionId));
     }
+    setError(null);
   };
 
   const errorMessage = error ?? (isInvalid ? VALIDATION_ERROR : null);
 
+  useEffect(() => {
+    const newCheckboxIdToSelectedMap = selectedLocations.reduce<Record<string, boolean>>(
+      (acc, location) => {
+        acc[location.id] = true;
+        return acc;
+      },
+      {}
+    );
+    setCheckboxIdToSelectedMap(newCheckboxIdToSelectedMap);
+  }, [selectedLocations]);
+
   return (
     <EuiFormRow label={LOCATIONS_LABEL} error={errorMessage} isInvalid={errorMessage !== null}>
-      <EuiComboBox
-        placeholder={PLACEHOLDER_LABEL}
-        options={locations}
-        selectedOptions={selectedLocations}
-        onChange={onLocationChange}
-        onSearchChange={onSearchChange}
-        onBlur={onBlur}
-        data-test-subj="syntheticsServiceLocationsComboBox"
+      <EuiCheckboxGroup
+        options={locations.map((location) => ({
+          ...location,
+          'data-test-subj': `syntheticsServiceLocation--${location.id}`,
+        }))}
+        idToSelectedMap={checkboxIdToSelectedMap}
+        onChange={(id) => onLocationChange(id)}
       />
     </EuiFormRow>
   );
 };
 
-const PLACEHOLDER_LABEL = i18n.translate(
-  'xpack.uptime.monitorManagement.serviceLocationsPlaceholderLabel',
-  {
-    defaultMessage: 'Select one or more locations to run your monitor.',
-  }
-);
-
 const VALIDATION_ERROR = i18n.translate(
   'xpack.uptime.monitorManagement.serviceLocationsValidationError',
   {
@@ -72,14 +70,6 @@ const VALIDATION_ERROR = i18n.translate(
   }
 );
 
-const getInvalidOptionError = (value: string) =>
-  i18n.translate('xpack.uptime.monitorManagement.serviceLocationsOptionError', {
-    defaultMessage: '"{value}" is not a valid option',
-    values: {
-      value,
-    },
-  });
-
 export const LOCATIONS_LABEL = i18n.translate(
   'xpack.uptime.monitorManagement.monitorLocationsLabel',
   {