diff --git a/x-pack/plugins/security_solution/common/endpoint/data_generators/host_isolation_exception_generator.ts b/x-pack/plugins/security_solution/common/endpoint/data_generators/host_isolation_exception_generator.ts
new file mode 100644
index 0000000000000..1790924182dfc
--- /dev/null
+++ b/x-pack/plugins/security_solution/common/endpoint/data_generators/host_isolation_exception_generator.ts
@@ -0,0 +1,39 @@
+/*
+ * Copyright Elasticsearch B.V. and/or licensed to Elasticsearch B.V. under one
+ * or more contributor license agreements. Licensed under the Elastic License
+ * 2.0; you may not use this file except in compliance with the Elastic License
+ * 2.0.
+ */
+
+import type { CreateExceptionListItemSchema } from '@kbn/securitysolution-io-ts-list-types';
+import { ENDPOINT_HOST_ISOLATION_EXCEPTIONS_LIST_ID } from '@kbn/securitysolution-list-constants';
+import { BaseDataGenerator } from './base_data_generator';
+import { getCreateExceptionListItemSchemaMock } from '../../../../lists/common/schemas/request/create_exception_list_item_schema.mock';
+
+export class HostIsolationExceptionGenerator extends BaseDataGenerator<CreateExceptionListItemSchema> {
+  generate(): CreateExceptionListItemSchema {
+    const overrides: Partial<CreateExceptionListItemSchema> = {
+      name: `generator exception ${this.randomString(5)}`,
+      list_id: ENDPOINT_HOST_ISOLATION_EXCEPTIONS_LIST_ID,
+      item_id: `generator_endpoint_host_isolation_exception_${this.randomUUID()}`,
+      os_types: ['windows', 'linux', 'macos'],
+      tags: ['policy:all'],
+      namespace_type: 'agnostic',
+      meta: undefined,
+      description: `Description ${this.randomString(5)}`,
+      entries: [
+        {
+          field: 'destination.ip',
+          operator: 'included',
+          type: 'match',
+          value: this.randomIP(),
+        },
+      ],
+    };
+
+    return Object.assign<CreateExceptionListItemSchema, Partial<CreateExceptionListItemSchema>>(
+      getCreateExceptionListItemSchemaMock(),
+      overrides
+    );
+  }
+}
diff --git a/x-pack/plugins/security_solution/scripts/endpoint/host_isolation_exceptions/index.ts b/x-pack/plugins/security_solution/scripts/endpoint/host_isolation_exceptions/index.ts
new file mode 100644
index 0000000000000..b9b70c4c1da19
--- /dev/null
+++ b/x-pack/plugins/security_solution/scripts/endpoint/host_isolation_exceptions/index.ts
@@ -0,0 +1,111 @@
+/*
+ * Copyright Elasticsearch B.V. and/or licensed to Elasticsearch B.V. under one
+ * or more contributor license agreements. Licensed under the Elastic License
+ * 2.0; you may not use this file except in compliance with the Elastic License
+ * 2.0.
+ */
+
+import { run, RunFn, createFailError } from '@kbn/dev-utils';
+import { KbnClient } from '@kbn/test';
+import { AxiosError } from 'axios';
+import bluebird from 'bluebird';
+import type { CreateExceptionListSchema } from '@kbn/securitysolution-io-ts-list-types';
+import {
+  ENDPOINT_HOST_ISOLATION_EXCEPTIONS_LIST_DESCRIPTION,
+  ENDPOINT_HOST_ISOLATION_EXCEPTIONS_LIST_ID,
+  ENDPOINT_HOST_ISOLATION_EXCEPTIONS_LIST_NAME,
+  EXCEPTION_LIST_ITEM_URL,
+  EXCEPTION_LIST_URL,
+} from '@kbn/securitysolution-list-constants';
+import { HostIsolationExceptionGenerator } from '../../../common/endpoint/data_generators/host_isolation_exception_generator';
+
+export const cli = () => {
+  run(
+    async (options) => {
+      try {
+        await createHostIsolationException(options);
+        options.log.success(`${options.flags.count} endpoint host isolation exceptions`);
+      } catch (e) {
+        options.log.error(e);
+        throw createFailError(e.message);
+      }
+    },
+    {
+      description: 'Load Host Isolation Exceptions',
+      flags: {
+        string: ['kibana'],
+        default: {
+          count: 10,
+          kibana: 'http://elastic:changeme@localhost:5601',
+        },
+        help: `
+        --count            Number of host isolation exceptions to create. Default: 10
+        --kibana           The URL to kibana including credentials. Default: http://elastic:changeme@localhost:5601
+      `,
+      },
+    }
+  );
+};
+
+class EventFilterDataLoaderError extends Error {
+  constructor(message: string, public readonly meta: unknown) {
+    super(message);
+  }
+}
+
+const handleThrowAxiosHttpError = (err: AxiosError): never => {
+  let message = err.message;
+
+  if (err.response) {
+    message = `[${err.response.status}] ${err.response.data.message ?? err.message} [ ${String(
+      err.response.config.method
+    ).toUpperCase()} ${err.response.config.url} ]`;
+  }
+  throw new EventFilterDataLoaderError(message, err.toJSON());
+};
+
+const createHostIsolationException: RunFn = async ({ flags, log }) => {
+  const eventGenerator = new HostIsolationExceptionGenerator();
+  const kbn = new KbnClient({ log, url: flags.kibana as string });
+
+  await ensureCreateEndpointHostIsolationExceptionList(kbn);
+
+  await bluebird.map(
+    Array.from({ length: flags.count as unknown as number }),
+    () =>
+      kbn
+        .request({
+          method: 'POST',
+          path: EXCEPTION_LIST_ITEM_URL,
+          body: eventGenerator.generate(),
+        })
+        .catch((e) => handleThrowAxiosHttpError(e)),
+    { concurrency: 10 }
+  );
+};
+
+const ensureCreateEndpointHostIsolationExceptionList = async (kbn: KbnClient) => {
+  const newListDefinition: CreateExceptionListSchema = {
+    description: ENDPOINT_HOST_ISOLATION_EXCEPTIONS_LIST_DESCRIPTION,
+    list_id: ENDPOINT_HOST_ISOLATION_EXCEPTIONS_LIST_ID,
+    meta: undefined,
+    name: ENDPOINT_HOST_ISOLATION_EXCEPTIONS_LIST_NAME,
+    os_types: [],
+    tags: [],
+    type: 'endpoint',
+    namespace_type: 'agnostic',
+  };
+
+  await kbn
+    .request({
+      method: 'POST',
+      path: EXCEPTION_LIST_URL,
+      body: newListDefinition,
+    })
+    .catch((e) => {
+      // Ignore if list was already created
+      if (e.response.status !== 409) {
+        handleThrowAxiosHttpError(e);
+      }
+    });
+};
diff --git a/x-pack/plugins/security_solution/scripts/endpoint/load_host_isolation_exceptions.js b/x-pack/plugins/security_solution/scripts/endpoint/load_host_isolation_exceptions.js
new file mode 100644
index 0000000000000..13fedecb690ca
--- /dev/null
+++ b/x-pack/plugins/security_solution/scripts/endpoint/load_host_isolation_exceptions.js
@@ -0,0 +1,11 @@
+#!/usr/bin/env node
+
+/*
+ * Copyright Elasticsearch B.V. and/or licensed to Elasticsearch B.V. under one
+ * or more contributor license agreements. Licensed under the Elastic License
+ * 2.0; you may not use this file except in compliance with the Elastic License
+ * 2.0.
+ */
+
+require('../../../../../src/setup_node_env');
+require('./host_isolation_exceptions').cli();