diff --git a/changelogs/upcoming/7473.md b/changelogs/upcoming/7473.md
new file mode 100644
index 00000000000..f77971bcc99
--- /dev/null
+++ b/changelogs/upcoming/7473.md
@@ -0,0 +1,3 @@
+**Bug fixes**
+
+- Fixed `EuiTextArea` to correctly fire `onChange` callbacks on clear button click
diff --git a/src/components/form/text_area/text_area.spec.tsx b/src/components/form/text_area/text_area.spec.tsx
index 0170b856709..a2ca9acc43e 100644
--- a/src/components/form/text_area/text_area.spec.tsx
+++ b/src/components/form/text_area/text_area.spec.tsx
@@ -26,23 +26,46 @@ describe('EuiTextArea', () => {
     });
 
     it('works for controlled components', () => {
+      const onChange = cy.stub();
       const ControlledTextArea = ({}) => {
         const [value, setValue] = useState('');
-        return (
-          <EuiTextArea
-            value={value}
-            onChange={(e) => setValue(e.target.value)}
-            isClearable
-          />
-        );
+        onChange.callsFake((e) => {
+          setValue(e.target.value);
+        });
+        return <EuiTextArea value={value} onChange={onChange} isClearable />;
       };
       cy.realMount(<ControlledTextArea />);
 
       cy.get('textarea').type('hello world');
-      cy.get('textarea').should('have.value', 'hello world');
+      cy.get('textarea')
+        .should('have.value', 'hello world')
+        .then(() => {
+          expect(onChange).to.have.callCount(11);
+        });
 
       cy.get('[data-test-subj="clearTextAreaButton"]').click();
-      cy.get('textarea').should('have.value', '');
+      cy.get('textarea')
+        .should('have.value', '')
+        .then(() => {
+          expect(onChange).to.have.callCount(12);
+        });
+    });
+
+    it('manually fires an onInput event', () => {
+      const onInput = cy.stub();
+      cy.realMount(<EuiTextArea isClearable onInput={onInput} />);
+
+      cy.get('textarea')
+        .type('1')
+        .then(() => {
+          expect(onInput).to.have.callCount(1);
+        });
+
+      cy.get('[data-test-subj="clearTextAreaButton"]')
+        .click()
+        .then(() => {
+          expect(onInput).to.have.callCount(2);
+        });
     });
   });
 });
diff --git a/src/components/form/text_area/text_area.tsx b/src/components/form/text_area/text_area.tsx
index d3253dc1742..fb1e95074c2 100644
--- a/src/components/form/text_area/text_area.tsx
+++ b/src/components/form/text_area/text_area.tsx
@@ -106,13 +106,22 @@ export const EuiTextArea: FunctionComponent<EuiTextAreaProps> = (props) => {
       return {
         onClick: () => {
           if (ref.current) {
-            ref.current.value = '';
+            // Updates the displayed value and fires `onChange` callbacks
+            // @see https://stackoverflow.com/questions/23892547/what-is-the-best-way-to-trigger-onchange-event-in-react-js
+            const nativeValueSetter = Object.getOwnPropertyDescriptor(
+              window.HTMLTextAreaElement.prototype,
+              'value'
+            )!.set!;
+            nativeValueSetter.call(ref.current, '');
+
             const event = new Event('input', {
               bubbles: true,
               cancelable: false,
             });
             ref.current.dispatchEvent(event);
-            ref.current.focus(); // set focus back to the textarea
+
+            // Set focus back to the textarea
+            ref.current.focus();
           }
         },
         'data-test-subj': 'clearTextAreaButton',