diff --git a/src-docs/src/views/datagrid/schema_columns/datagrid_columns_example.js b/src-docs/src/views/datagrid/schema_columns/datagrid_columns_example.js
index e553d1dccaf..cc5f073c1a9 100644
--- a/src-docs/src/views/datagrid/schema_columns/datagrid_columns_example.js
+++ b/src-docs/src/views/datagrid/schema_columns/datagrid_columns_example.js
@@ -298,6 +298,11 @@ schemaDetectors={[
             <EuiCode>EuiDataGridCellValueElementProps</EuiCode> and returning a
             React node.
           </p>
+          <p>
+            When rendering footer cell values, we encourage turning off cell
+            expansion on cells without content with{' '}
+            <EuiCode>setCellProps({'{ isExpandable: false }'})</EuiCode>.
+          </p>
         </Fragment>
       ),
       props: {
diff --git a/src-docs/src/views/datagrid/schema_columns/footer_row.js b/src-docs/src/views/datagrid/schema_columns/footer_row.js
index 4f5cdc4ebc8..4222e2fa4a5 100644
--- a/src-docs/src/views/datagrid/schema_columns/footer_row.js
+++ b/src-docs/src/views/datagrid/schema_columns/footer_row.js
@@ -66,17 +66,24 @@ const columns = [
 ];
 
 const footerCellValues = {
-  amount: `Total: $${raw_data.reduce(
-    (acc, { amount }) => acc + Number(amount.split('$')[1]),
-    0
-  )}`,
+  amount: `Total: ${raw_data
+    .reduce((acc, { amount }) => acc + Number(amount.split('$')[1]), 0)
+    .toLocaleString('en-US', { style: 'currency', currency: 'USD' })}`,
   version: `Latest: ${
     raw_data.map(({ version }) => version).sort()[raw_data.length - 1]
   }`,
 };
 
-const renderFooterCellValue = ({ columnId }) =>
-  footerCellValues[columnId] || null;
+const RenderFooterCellValue = ({ columnId, setCellProps }) => {
+  const value = footerCellValues[columnId];
+
+  useEffect(() => {
+    // Turn off the cell expansion button if the footer cell is empty
+    if (!value) setCellProps({ isExpandable: false });
+  }, [value, setCellProps]);
+
+  return value || null;
+};
 
 export default () => {
   // Pagination
@@ -121,7 +128,7 @@ export default () => {
           rowCount={raw_data.length}
           renderCellValue={RenderCellValue}
           renderFooterCellValue={
-            showFooterRow ? renderFooterCellValue : undefined
+            showFooterRow ? RenderFooterCellValue : undefined
           }
           pagination={{
             ...pagination,
diff --git a/src/components/datagrid/body/data_grid_footer_row.spec.tsx b/src/components/datagrid/body/data_grid_footer_row.spec.tsx
new file mode 100644
index 00000000000..bae4600c7ae
--- /dev/null
+++ b/src/components/datagrid/body/data_grid_footer_row.spec.tsx
@@ -0,0 +1,94 @@
+/*
+ * Copyright Elasticsearch B.V. and/or licensed to Elasticsearch B.V. under one
+ * or more contributor license agreements. Licensed under the Elastic License
+ * 2.0 and the Server Side Public License, v 1; you may not use this file except
+ * in compliance with, at your election, the Elastic License 2.0 or the Server
+ * Side Public License, v 1.
+ */
+
+/// <reference types="../../../../cypress/support"/>
+
+import React, { useState, useEffect } from 'react';
+import { EuiDataGrid } from '../';
+
+describe('EuiDataGridFooterRow', () => {
+  const mockData = [10, 15, 20];
+
+  const RenderCellValue = ({ rowIndex, columnId }) =>
+    columnId === 'b' ? mockData[rowIndex] : null;
+
+  const RenderFooterCellValue = ({ columnId, setCellProps }) => {
+    const value = columnId === 'b' ? mockData.reduce((a, b) => a + b, 0) : null;
+
+    useEffect(() => {
+      if (!value) setCellProps({ isExpandable: false });
+    }, [value, setCellProps]);
+
+    return value;
+  };
+
+  // We need to set up a test component here for column ordering to work
+  const GridTest = () => {
+    const [visibleColumns, setVisibleColumns] = useState(['a', 'b']);
+
+    return (
+      <EuiDataGrid
+        aria-label="Footer row tests"
+        columns={[{ id: 'a' }, { id: 'b', display: 'Total' }]}
+        columnVisibility={{ visibleColumns, setVisibleColumns }}
+        rowCount={3}
+        renderCellValue={RenderCellValue}
+        renderFooterCellValue={RenderFooterCellValue}
+      />
+    );
+  };
+  GridTest.displayName = 'GridTest';
+
+  it('renders a footer of total values', () => {
+    cy.mount(<GridTest />);
+
+    cy.get(
+      '[data-gridcell-column-index="1"][data-gridcell-row-index="3"]'
+    ).contains('45');
+  });
+
+  it('does not render an expansion button for the empty footer cell', () => {
+    cy.mount(<GridTest />);
+
+    cy.get(
+      '[data-gridcell-column-index="0"][data-gridcell-row-index="3"]'
+    ).click();
+    cy.get('[data-test-subj="euiDataGridCellExpandButton"]').should(
+      'not.exist'
+    );
+  });
+
+  // Regression test for #5720
+  it('does not bug focus when moving a column and then clicking its footer cell', () => {
+    cy.mount(<GridTest />);
+
+    cy.get(
+      '[data-gridcell-column-index="1"][data-gridcell-row-index="-1"]'
+    ).click();
+    cy.contains('Move left').click();
+
+    cy.get('[data-gridcell-column-index="0"][data-gridcell-row-index="3"]')
+      .click()
+      .contains('45')
+      .click();
+
+    // Note that the wait/timeout and multiple focused assertions are required for
+    // for this specific bug which bounces focus rapidly between cells, as otherwise
+    // Cypress re-tries until it happens to be on the cell with correct attributes
+    cy.wait(50);
+    const checkFocusedCell = () => {
+      cy.wait(1);
+      cy.focused({ timeout: 0 })
+        .should('have.attr', 'data-gridcell-column-index', '0')
+        .should('not.have.attr', 'data-gridcell-column-index', '1');
+    };
+    checkFocusedCell();
+    checkFocusedCell();
+    checkFocusedCell();
+  });
+});
diff --git a/src/components/datagrid/body/data_grid_footer_row.test.tsx b/src/components/datagrid/body/data_grid_footer_row.test.tsx
index 33af4964473..eca2c81be9c 100644
--- a/src/components/datagrid/body/data_grid_footer_row.test.tsx
+++ b/src/components/datagrid/body/data_grid_footer_row.test.tsx
@@ -39,7 +39,7 @@ describe('EuiDataGridFooterRow', () => {
           columnType="string"
           interactiveCellId="someId"
           isExpandable={true}
-          key="someColumn-10"
+          key="0,10"
           popoverContext={
             Object {
               "cellLocation": Object {
@@ -65,7 +65,7 @@ describe('EuiDataGridFooterRow', () => {
           columnType={null}
           interactiveCellId="someId"
           isExpandable={true}
-          key="someColumnWithoutSchema-10"
+          key="1,10"
           popoverContext={
             Object {
               "cellLocation": Object {
diff --git a/src/components/datagrid/body/data_grid_footer_row.tsx b/src/components/datagrid/body/data_grid_footer_row.tsx
index fea8bdc8ea7..ca78dacc3cd 100644
--- a/src/components/datagrid/body/data_grid_footer_row.tsx
+++ b/src/components/datagrid/body/data_grid_footer_row.tsx
@@ -81,7 +81,7 @@ const EuiDataGridFooterRow = memo(
             return (
               <EuiDataGridCell
                 {...sharedCellProps}
-                key={`${id}-${rowIndex}`}
+                key={`${columnPosition},${visibleRowIndex}`} // Note: this key should use cell position to match react-window/data cell behavior. See #5720
                 colIndex={columnPosition}
                 columnId={id}
                 columnType={columnType}
diff --git a/upcoming_changelogs/5720.md b/upcoming_changelogs/5720.md
new file mode 100644
index 00000000000..77401a5208e
--- /dev/null
+++ b/upcoming_changelogs/5720.md
@@ -0,0 +1,3 @@
+**Bug fixes**
+
+- Fixed `EuiDataGrid` footer cell focus bugging out after moving its column