diff --git a/CHANGELOG.md b/CHANGELOG.md
index 1bbc092b573..c014458e0c0 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,6 +1,8 @@
 ## [`main`](https://github.com/elastic/eui/tree/main)
 
-No public interface changes since `46.1.0`.
+**Bug fixes**
+
+- Fixed EuiDataGrid height issue when in full-screen mode and with scrolling content ([#5557](https://github.com/elastic/eui/pull/5557))
 
 ## [`46.1.0`](https://github.com/elastic/eui/tree/v46.1.0)
 
diff --git a/src/components/datagrid/body/data_grid_body.test.tsx b/src/components/datagrid/body/data_grid_body.test.tsx
index a6fe83ddf1a..80ae06ffbc7 100644
--- a/src/components/datagrid/body/data_grid_body.test.tsx
+++ b/src/components/datagrid/body/data_grid_body.test.tsx
@@ -17,11 +17,9 @@ import { EuiDataGridBody, Cell } from './data_grid_body';
 
 describe('EuiDataGridBody', () => {
   const requiredProps = {
-    isFullScreen: false,
     headerIsInteractive: true,
     rowCount: 1,
     visibleRows: { startRow: 0, endRow: 1, visibleRowCount: 1 },
-    toolbarHeight: 10,
     columnWidths: { columnA: 20 },
     columns: [
       { id: 'columnA', schema: 'boolean' },
diff --git a/src/components/datagrid/body/data_grid_body.tsx b/src/components/datagrid/body/data_grid_body.tsx
index e6912ae358e..f4771e1bd1c 100644
--- a/src/components/datagrid/body/data_grid_body.tsx
+++ b/src/components/datagrid/body/data_grid_body.tsx
@@ -219,7 +219,6 @@ export const EuiDataGridBody: FunctionComponent<EuiDataGridBodyProps> = (
   props
 ) => {
   const {
-    isFullScreen,
     leadingControlColumns,
     trailingControlColumns,
     columns,
@@ -238,7 +237,6 @@ export const EuiDataGridBody: FunctionComponent<EuiDataGridBodyProps> = (
     setVisibleColumns,
     switchColumnPos,
     onColumnResize,
-    toolbarHeight,
     rowHeightsOptions,
     virtualizationOptions,
     gridStyles,
@@ -416,11 +414,7 @@ export const EuiDataGridBody: FunctionComponent<EuiDataGridBodyProps> = (
     unconstrainedWidth: 0, // unable to determine this until the container's size is known
     wrapperDimensions,
     wrapperRef,
-    toolbarHeight,
-    headerRowHeight,
-    footerRowHeight,
     rowCount,
-    isFullScreen,
   });
 
   /**
diff --git a/src/components/datagrid/controls/data_grid_toolbar.test.tsx b/src/components/datagrid/controls/data_grid_toolbar.test.tsx
index 6a5683220d5..c231b87aa4c 100644
--- a/src/components/datagrid/controls/data_grid_toolbar.test.tsx
+++ b/src/components/datagrid/controls/data_grid_toolbar.test.tsx
@@ -25,7 +25,6 @@ describe('EuiDataGridToolbar', () => {
     controlBtnClasses: '',
     columnSelector: <div>mock column selector</div>,
     columnSorting: <div>mock column sorting</div>,
-    setRef: jest.fn(),
     setIsFullScreen: jest.fn(),
   };
 
diff --git a/src/components/datagrid/controls/data_grid_toolbar.tsx b/src/components/datagrid/controls/data_grid_toolbar.tsx
index cf66c9da15c..eeb3ab05049 100644
--- a/src/components/datagrid/controls/data_grid_toolbar.tsx
+++ b/src/components/datagrid/controls/data_grid_toolbar.tsx
@@ -34,7 +34,6 @@ export const EuiDataGridToolbar = ({
   displaySelector,
   columnSelector,
   columnSorting,
-  setRef,
   setIsFullScreen,
 }: EuiDataGridToolbarProps) => {
   const [fullScreenButton, fullScreenButtonActive] = useEuiI18n(
@@ -86,11 +85,7 @@ export const EuiDataGridToolbar = ({
   );
 
   return (
-    <div
-      ref={setRef}
-      className="euiDataGrid__controls"
-      data-test-sub="dataGridControls"
-    >
+    <div className="euiDataGrid__controls" data-test-sub="dataGridControls">
       {hasRoomForGridControls && (
         <div className="euiDataGrid__leftControls">
           {renderAdditionalControls(toolbarVisibility, 'left.prepend')}
diff --git a/src/components/datagrid/data_grid.tsx b/src/components/datagrid/data_grid.tsx
index 15f49ec113d..5eaeb66a69f 100644
--- a/src/components/datagrid/data_grid.tsx
+++ b/src/components/datagrid/data_grid.tsx
@@ -162,8 +162,10 @@ export const EuiDataGrid: FunctionComponent<EuiDataGridProps> = (props) => {
    * Grid refs & observers
    */
   // Outermost wrapper div
-  const resizeRef = useRef<HTMLDivElement | null>(null);
-  const { width: gridWidth } = useResizeObserver(resizeRef.current, 'width');
+  // this ref needs to be managed by a state, to cause a re-render after mount
+  // and passing the mounted element to the resize observer
+  const [resizeRef, setResizeRef] = useState<HTMLDivElement | null>(null);
+  const { width: gridWidth } = useResizeObserver(resizeRef, 'width');
 
   // Wrapper div around EuiDataGridBody
   const contentRef = useRef<HTMLDivElement | null>(null);
@@ -270,8 +272,6 @@ export const EuiDataGrid: FunctionComponent<EuiDataGridProps> = (props) => {
    * Toolbar & full-screen
    */
   const showToolbar = !!toolbarVisibility;
-  const [toolbarRef, setToolbarRef] = useState<HTMLDivElement | null>(null);
-  const { height: toolbarHeight } = useResizeObserver(toolbarRef, 'height');
 
   const [isFullScreen, setIsFullScreen] = useState(false);
   const handleGridKeyDown = (event: KeyboardEvent<HTMLDivElement>) => {
@@ -368,12 +368,11 @@ export const EuiDataGrid: FunctionComponent<EuiDataGridProps> = (props) => {
             className={classes}
             onKeyDown={handleGridKeyDown}
             style={isFullScreen ? undefined : { width, height }}
-            ref={resizeRef}
+            ref={setResizeRef}
             {...rest}
           >
             {showToolbar && (
               <EuiDataGridToolbar
-                setRef={setToolbarRef}
                 gridWidth={gridWidth}
                 minSizeForControls={minSizeForControls}
                 toolbarVisibility={toolbarVisibility}
@@ -422,10 +421,8 @@ export const EuiDataGrid: FunctionComponent<EuiDataGridProps> = (props) => {
               {...gridAriaProps}
             >
               <EuiDataGridBody
-                isFullScreen={isFullScreen}
                 columns={orderedVisibleColumns}
                 visibleColCount={visibleColCount}
-                toolbarHeight={toolbarHeight}
                 leadingControlColumns={leadingControlColumns}
                 schema={mergedSchema}
                 trailingControlColumns={trailingControlColumns}
diff --git a/src/components/datagrid/data_grid_types.ts b/src/components/datagrid/data_grid_types.ts
index 9100ab2fc93..b0acaeeb7e1 100644
--- a/src/components/datagrid/data_grid_types.ts
+++ b/src/components/datagrid/data_grid_types.ts
@@ -40,9 +40,9 @@ export interface EuiDataGridToolbarProps {
   controlBtnClasses: string;
   columnSelector: ReactNode;
   columnSorting: ReactNode;
-  setRef: RefCallback<HTMLDivElement | null>;
   setIsFullScreen: Dispatch<SetStateAction<boolean>>;
 }
+
 export interface EuiDataGridPaginationRendererProps
   extends EuiDataGridPaginationProps {
   rowCount: number;
@@ -327,7 +327,6 @@ export interface EuiDataGridColumnSortingDraggableProps {
   display: string;
 }
 export interface EuiDataGridBodyProps {
-  isFullScreen: boolean;
   leadingControlColumns: EuiDataGridControlColumn[];
   trailingControlColumns: EuiDataGridControlColumn[];
   columns: EuiDataGridColumn[];
@@ -346,7 +345,6 @@ export interface EuiDataGridBodyProps {
   setVisibleColumns: EuiDataGridHeaderRowProps['setVisibleColumns'];
   switchColumnPos: EuiDataGridHeaderRowProps['switchColumnPos'];
   onColumnResize?: EuiDataGridOnColumnResizeHandler;
-  toolbarHeight: number;
   virtualizationOptions?: Partial<VariableSizeGridProps>;
   rowHeightsOptions?: EuiDataGridRowHeightsOptions;
   gridStyles: EuiDataGridStyle;
diff --git a/src/components/datagrid/utils/grid_height_width.ts b/src/components/datagrid/utils/grid_height_width.ts
index 948bf269efc..a5c37a116b0 100644
--- a/src/components/datagrid/utils/grid_height_width.ts
+++ b/src/components/datagrid/utils/grid_height_width.ts
@@ -19,21 +19,13 @@ export const useFinalGridDimensions = ({
   unconstrainedWidth,
   wrapperDimensions,
   wrapperRef,
-  toolbarHeight,
-  headerRowHeight,
-  footerRowHeight,
   rowCount,
-  isFullScreen,
 }: {
   unconstrainedHeight: number;
   unconstrainedWidth: number;
   wrapperDimensions: { width: number; height: number };
   wrapperRef: MutableRefObject<HTMLDivElement | null>;
-  toolbarHeight: number;
-  headerRowHeight: number;
-  footerRowHeight: number;
   rowCount: number;
-  isFullScreen: boolean;
 }) => {
   // Used if the grid needs to scroll
   const [height, setHeight] = useState<number | undefined>(undefined);
@@ -43,7 +35,7 @@ export const useFinalGridDimensions = ({
   useEffect(() => {
     const boundingRect = wrapperRef.current!.getBoundingClientRect();
 
-    if (boundingRect.height !== unconstrainedHeight && !isFullScreen) {
+    if (boundingRect.height !== unconstrainedHeight) {
       setHeight(boundingRect.height);
     }
     if (boundingRect.width !== unconstrainedWidth) {
@@ -57,22 +49,15 @@ export const useFinalGridDimensions = ({
     wrapperRef,
     unconstrainedHeight,
     unconstrainedWidth,
-    isFullScreen,
   ]);
 
-  let finalHeight = IS_JEST_ENVIRONMENT
+  const finalHeight = IS_JEST_ENVIRONMENT
     ? Number.MAX_SAFE_INTEGER
     : height || unconstrainedHeight;
-  let finalWidth = IS_JEST_ENVIRONMENT
+  const finalWidth = IS_JEST_ENVIRONMENT
     ? Number.MAX_SAFE_INTEGER
     : width || unconstrainedWidth;
 
-  if (isFullScreen) {
-    finalHeight =
-      window.innerHeight - toolbarHeight - headerRowHeight - footerRowHeight;
-    finalWidth = window.innerWidth;
-  }
-
   return { finalHeight, finalWidth };
 };