diff --git a/build/scripts/Build.fs b/build/scripts/Build.fs
index c5fe17fad..8d1f6240c 100644
--- a/build/scripts/Build.fs
+++ b/build/scripts/Build.fs
@@ -124,7 +124,7 @@ module Build =
     /// When running on Windows and not CI, also runs MSBuild Build on .NET Framework
     let Build () =
         // On Windows, pre-build this first to prevent a parallel build race condition: both
-        // Elastic.Apm.Profiler.Managed (net462 TFM) and AspNetFullFrameworkSampleApp reference
+        // Elastic.Apm.Profiler.Managed (net462 and net472 TFMs) and AspNetFullFrameworkSampleApp reference
         // Elastic.Apm.AspNetFullFramework, so a parallel solution build can hit a file lock
         // on the obj DLL. Pre-building ensures the output exists and incremental build skips it.
         if isWindows then dotnet "build" aspNetFullFramework
@@ -320,7 +320,7 @@ module Build =
         )
 
         Directory.GetDirectories((Paths.BuildOutput "Elastic.Apm.Profiler.Managed"), "*", SearchOption.TopDirectoryOnly)
-        |> Array.filter (fun dir -> isWindows || not (dir.EndsWith("net462")))
+        |> Array.filter (fun dir -> isWindows || (not (dir.EndsWith("net462")) && not (dir.EndsWith("net472"))))
         |> Seq.map DirectoryInfo
         |> Seq.iter (fun sourceDir -> copyDllsAndPdbs (profilerDir.CreateSubdirectory(sourceDir.Name)) sourceDir)
         
diff --git a/src/profiler/Elastic.Apm.Profiler.Managed.Loader/Startup.NetFramework.cs b/src/profiler/Elastic.Apm.Profiler.Managed.Loader/Startup.NetFramework.cs
index e5cd72d9e..562052db7 100644
--- a/src/profiler/Elastic.Apm.Profiler.Managed.Loader/Startup.NetFramework.cs
+++ b/src/profiler/Elastic.Apm.Profiler.Managed.Loader/Startup.NetFramework.cs
@@ -11,6 +11,7 @@
 using System;
 using System.IO;
 using System.Reflection;
+using Microsoft.Win32;
 
 namespace Elastic.Apm.Profiler.Managed.Loader
 {
@@ -18,9 +19,46 @@ public partial class Startup
 	{
 		private static string ResolveDirectory()
 		{
-			var framework = "net462";
 			var directory = ReadEnvironmentVariable("ELASTIC_APM_PROFILER_HOME") ?? string.Empty;
-			return Path.Combine(directory, framework);
+
+			// Prefer the net472 build on .NET Framework 4.7.2+ — it supports VerifyServerCert and ServerCert
+			// via HttpClientHandler.ServerCertificateCustomValidationCallback (added in 4.7.1).
+			// Fall back to net462 if the net472 directory is absent (e.g. older profiler zip) so loading
+			// still succeeds rather than silently failing to resolve assemblies.
+			if (IsNet472OrHigher())
+			{
+				var net472Dir = Path.Combine(directory, "net472");
+				if (System.IO.Directory.Exists(net472Dir))
+				{
+					Logger.Log(LogLevel.Debug, "Resolving assemblies from {0}", net472Dir);
+					return net472Dir;
+				}
+
+				Logger.Log(LogLevel.Warning,
+					"Running on .NET Framework 4.7.2+ but net472 directory not found at {0}. "
+					+ "Falling back to net462: VerifyServerCert and ServerCert will have no effect.",
+					net472Dir);
+			}
+
+			var net462Dir = Path.Combine(directory, "net462");
+			Logger.Log(LogLevel.Debug, "Resolving assemblies from {0}", net462Dir);
+			return net462Dir;
+		}
+
+		private static bool IsNet472OrHigher()
+		{
+			try
+			{
+				using var key = Registry.LocalMachine.OpenSubKey(@"SOFTWARE\Microsoft\NET Framework Setup\NDP\v4\Full");
+				// Release value 461808 corresponds to .NET Framework 4.7.2 on Windows 10 1803+;
+				// 461814 is the value for all other OS versions. Checking >= 461808 covers both.
+				var release = Convert.ToInt32(key?.GetValue("Release") ?? 0);
+				return release >= 461808;
+			}
+			catch
+			{
+				return false;
+			}
 		}
 
 		private static Assembly ResolveDependencies(object sender, ResolveEventArgs args)
diff --git a/src/profiler/Elastic.Apm.Profiler.Managed/Elastic.Apm.Profiler.Managed.csproj b/src/profiler/Elastic.Apm.Profiler.Managed/Elastic.Apm.Profiler.Managed.csproj
index c476d2bd4..183530d7e 100644
--- a/src/profiler/Elastic.Apm.Profiler.Managed/Elastic.Apm.Profiler.Managed.csproj
+++ b/src/profiler/Elastic.Apm.Profiler.Managed/Elastic.Apm.Profiler.Managed.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>net462;netstandard2.0;netstandard2.1;net8.0</TargetFrameworks>
+    <TargetFrameworks>net462;net472;netstandard2.0;netstandard2.1;net8.0</TargetFrameworks>
     <IsPackable>false</IsPackable>
     <DefineConstants>$(DefineConstants);PROFILER_MANAGED</DefineConstants>
   </PropertyGroup>
@@ -12,26 +12,24 @@
     <Compile Include="$(SolutionRoot)src/profiler/Elastic.Apm.Profiler.Managed.Loader/Logger.cs" />
   </ItemGroup>
 
-
-  <ItemGroup Condition="'$(TargetFramework)' != 'net462'">
+  <ItemGroup Condition="'$(TargetFramework)' != 'net462' And '$(TargetFramework)' != 'net472'">
     <PackageReference Include="System.Reflection.Emit" />
     <PackageReference Include="System.Reflection.Emit.Lightweight" />
   </ItemGroup>
 
-  <!-- ASP.NET integration -->
-  <ItemGroup Condition="'$(TargetFramework)' == 'net462'">
+  <!-- ASP.NET Full Framework integration (net462, net472) -->
+  <ItemGroup Condition="'$(TargetFramework)' == 'net462' Or '$(TargetFramework)' == 'net472'">
     <ProjectReference Include="$(SrcIntegrations)\Elastic.Apm.AspNetFullFramework\Elastic.Apm.AspNetFullFramework.csproj" />
     <Reference Include="System.Web" />
   </ItemGroup>
-  <!-- ASP.NET Core integration -->
-  <ItemGroup  Condition="'$(TargetFramework)' != 'net462'">
+  <!-- ASP.NET Core integration (netstandard, net8+) -->
+  <ItemGroup Condition="'$(TargetFramework)' != 'net462' And '$(TargetFramework)' != 'net472'">
     <ProjectReference Include="$(SrcIntegrations)\Elastic.Apm.AspNetCore\Elastic.Apm.AspNetCore.csproj" />
   </ItemGroup>
 
   <ItemGroup>
     <ProjectReference Include="..\Elastic.Apm.Profiler.Managed.Core\Elastic.Apm.Profiler.Managed.Core.csproj" />
     <ProjectReference Include="..\..\Elastic.Apm\Elastic.Apm.csproj" />
-    <ProjectReference Include="$(SrcIntegrations)\Elastic.Apm.AspNetCore\Elastic.Apm.AspNetCore.csproj" />
   </ItemGroup>
 
   <ItemGroup>