diff --git a/easybuild/easyconfigs/h/hmmlearn/hmmlearn-0.3.3-gfbf-2024a.eb b/easybuild/easyconfigs/h/hmmlearn/hmmlearn-0.3.3-gfbf-2024a.eb
new file mode 100644
index 000000000000..1e5272327ad5
--- /dev/null
+++ b/easybuild/easyconfigs/h/hmmlearn/hmmlearn-0.3.3-gfbf-2024a.eb
@@ -0,0 +1,20 @@
+easyblock = 'PythonPackage'
+
+name = 'hmmlearn'
+version = '0.3.3'
+
+homepage = 'https://github.com/hmmlearn/hmmlearn'
+description = "hmmlearn is a set of algorithms for unsupervised learning and inference of Hidden Markov Models"
+
+toolchain = {'name': 'gfbf', 'version': '2024a'}
+
+sources = [SOURCE_TAR_GZ]
+checksums = ['1d3c5dc4c5257e0c238dc1fe5387700b8cb987eab808edb3e0c73829f1cc44ec']
+
+dependencies = [
+    ('Python', '3.12.3'),
+    ('scikit-learn', '1.5.2'),
+    ('pybind11', '2.12.0'),
+]
+
+moduleclass = 'lib'
diff --git a/easybuild/easyconfigs/m/MACS3/MACS3-3.0.3-gfbf-2024a.eb b/easybuild/easyconfigs/m/MACS3/MACS3-3.0.3-gfbf-2024a.eb
new file mode 100644
index 000000000000..eced8a93e0a1
--- /dev/null
+++ b/easybuild/easyconfigs/m/MACS3/MACS3-3.0.3-gfbf-2024a.eb
@@ -0,0 +1,35 @@
+easyblock = 'PythonBundle'
+
+name = 'MACS3'
+version = '3.0.3'
+
+homepage = 'https://macs3-project.github.io/MACS/'
+description = """Model Based Analysis for ChIP-Seq data"""
+
+toolchain = {'name': 'gfbf', 'version': '2024a'}
+
+builddependencies = [
+    ('pybind11', '2.12.0'),
+    ('Cython', '3.0.10'),
+]
+
+dependencies = [
+    ('Python', '3.12.3'),
+    ('SciPy-bundle', '2024.05'),
+    ('matplotlib', '3.9.2'),
+    ('hmmlearn', '0.3.3'),
+]
+
+exts_list = [
+    ('cykhash', '2.0.1', {
+        'checksums': ['b4794bc9f549114d8cf1d856d9f64e08ff5f246bf043cf369fdb414e9ceb97f7'],
+    }),
+    ('%(namelower)s', version, {
+        'checksums': ['ee1c892901c4010ff9e201b433c0623cbd747a3058300322386a7185623b1684'],
+        'modulename': 'MACS3',
+    }),
+]
+
+sanity_check_commands = ["macs3 --help"]
+
+moduleclass = 'bio'