diff --git a/easybuild/easyconfigs/m/Mathematica/Mathematica-14.2.1.eb b/easybuild/easyconfigs/m/Mathematica/Mathematica-14.2.1.eb
new file mode 100644
index 000000000000..52b6292ed728
--- /dev/null
+++ b/easybuild/easyconfigs/m/Mathematica/Mathematica-14.2.1.eb
@@ -0,0 +1,29 @@
+name = "Mathematica"
+version = "14.2.1"
+
+homepage = "https://www.wolfram.com/mathematica"
+docurls = "https://reference.wolfram.com/language/"
+description = """
+    Mathematica is a computational software program
+    used in many scientific, engineering, mathematical and computing fields.
+"""
+toolchain = SYSTEM
+
+sources = ["Wolfram_%(version)s_LIN.sh"]
+checksums = ['58d2eeabd46f898177323f2e3802e19af7311861d5abf4c0185313196a1805c7']
+download_instructions = """
+Only the latest minor version release of the product can be downloaded from
+https://user.wolfram.com/portal/myProducts.html
+"""
+
+postinstallmsgs = [
+    "This Mathematica/Wolfram installer includes Qt6. Please ensure that your compute nodes ",
+    "have the necessary dependencies available (see https://support.wolfram.com/59044), or alternatively, ",
+    "load the Qt6 module together with this module. ",
+]
+
+license_server = "!license.example.com"
+
+modloadmsg = "To start the notebook interface, commonly called the front end, use the wolframnb CLI command."
+
+moduleclass = "math"