diff --git a/easybuild/easyconfigs/e/epiScanpy/epiScanpy-0.4.0-foss-2023a.eb b/easybuild/easyconfigs/e/epiScanpy/epiScanpy-0.4.0-foss-2023a.eb
new file mode 100644
index 000000000000..552e826a3a24
--- /dev/null
+++ b/easybuild/easyconfigs/e/epiScanpy/epiScanpy-0.4.0-foss-2023a.eb
@@ -0,0 +1,47 @@
+easyblock = 'PythonBundle'
+
+name = 'epiScanpy'
+version = '0.4.0'
+
+homepage = 'https://github.com/colomemaria/episcanpy'
+description = """EpiScanpy is a toolkit to analyse single-cell open chromatin
+(scATAC-seq) and single-cell DNA methylation (for example scBS-seq)
+data. EpiScanpy is the epigenomic extension of the very popular scRNA-seq
+analysis tool Scanpy (Genome Biology, 2018) [Wolf18]."""
+
+toolchain = {'name': 'foss', 'version': '2023a'}
+
+dependencies = [
+    ('Python', '3.11.3'),
+    ('SciPy-bundle', '2023.07'),
+    ('Seaborn', '0.13.2'),
+    ('scanpy', '1.9.8'),  # includes anndata
+    ('Pysam', '0.22.0'),
+    ('scikit-learn', '1.3.1'),
+    ('statsmodels', '0.14.1'),
+    ('numba', '0.58.1'),
+    ('python-igraph', '0.11.4'),
+    ('tbb', '2021.11.0'),
+]
+
+exts_list = [
+    ('bamnostic', '1.1.10', {
+        'checksums': ['2f7e7e5cb693c5f933c5b5c3fde49c6c8dee62b608ebd13a4604401573e37017'],
+    }),
+    ('legacy_api_wrap', '1.4', {
+        'checksums': ['92dfa274cedb26d6e6f70fac85c856fbdcc05058066656d76a665fb4bf11b785'],
+    }),
+    ('kneed', '0.8.5', {
+        'checksums': ['a4847ac4f1d04852fea278d5de7aa8bfdc3beb7fbca4a182fec0f0efee43f4b1'],
+    }),
+    ('episcanpy', version, {
+        # strip out tbb as required dependency, to ensure that 'pip check' passes
+        'preinstallopts': "sed -i 's/tbb//' requirements.txt && ",
+        'checksums': ['95739149db60521b0a14e4579f8ba87d410126ffb7b916abbc2d1aff3df40ce3'],
+    }),
+]
+
+use_pip = True
+sanity_pip_check = True
+
+moduleclass = 'bio'