diff --git a/easybuild/easyblocks/l/llvm.py b/easybuild/easyblocks/l/llvm.py
index 4a024cdcd51..3c7f863e007 100644
--- a/easybuild/easyblocks/l/llvm.py
+++ b/easybuild/easyblocks/l/llvm.py
@@ -237,6 +237,9 @@ def __init__(self, *args, **kwargs):
         """Initialize LLVM-specific variables."""
         super().__init__(*args, **kwargs)
 
+        # List of (lower-case) dependencies
+        self.deps = [dep['name'].lower() for dep in self.cfg.dependencies(runtime_only=True)]
+
         if self.cfg['usepolly'] is not None:
             self.log.deprecated("Use of easyconfig parameter 'usepolly', replace by 'use_polly'", '6.0')
             if self.cfg['use_polly'] is None:
@@ -434,9 +437,6 @@ def _configure_build_targets(self):
                 print_warning("Both 'amd_gfx_list' and build option 'amdgcn_capabilities' "
                               "are set, please use only the build option 'amdgcn_capabilities'")
 
-        # List of (lower-case) dependencies
-        self.deps = [dep['name'].lower() for dep in self.cfg.dependencies()]
-
         # Build targets
         build_targets = self.cfg['build_targets'] or []
         if not build_targets:
@@ -522,6 +522,10 @@ def _configure_build_targets(self):
         self.general_opts['CMAKE_BUILD_TYPE'] = self.build_type
         self.general_opts['LLVM_TARGETS_TO_BUILD'] = self.list_to_cmake_arg(build_targets)
 
+    def get_dependency_root(self, name: str):
+        """Get software root of dependency. Return None if it is not a dependecy."""
+        return get_software_root(name) if name.lower() in self.deps else None
+
     def prepare_step(self, *args, **kwargs):
         """Prepare step, modified to ensure install dir is deleted before building"""
         super().prepare_step(*args, **kwargs)
@@ -555,7 +559,7 @@ def _configure_final_build(self):
         self._cmakeopts['LLVM_ENABLE_PROJECTS'] = self.list_to_cmake_arg(self.final_projects)
         self._cmakeopts['LLVM_ENABLE_RUNTIMES'] = self.list_to_cmake_arg(self.final_runtimes)
 
-        hwloc_root = get_software_root('hwloc')
+        hwloc_root = self.get_dependency_root('hwloc')
         if hwloc_root:
             self.log.info("Using %s as hwloc root", hwloc_root)
             self._cmakeopts['LIBOMP_USE_HWLOC'] = 'ON'
@@ -870,7 +874,7 @@ def configure_step(self):
 
         # Dependencies based persistent options (should be reused across stages)
         # Libxml2
-        xml2_root = get_software_root('libxml2')
+        xml2_root = self.get_dependency_root('libxml2')
         # Explicitly disable libxml2 if not found to avoid linking against system libxml2
         if xml2_root:
             if self.full_llvm:
@@ -881,7 +885,7 @@ def configure_step(self):
         else:
             self.general_opts['LLVM_ENABLE_LIBXML2'] = 'OFF'
 
-        libffi_root = get_software_root('libffi')
+        libffi_root = self.get_dependency_root('libffi')
         self.general_opts['LLVM_ENABLE_FFI'] = 'ON' if libffi_root else 'OFF'
         if libffi_root:
             self.general_opts['FFI_INCLUDE_DIR'] = os.path.join(libffi_root, 'include')
@@ -889,16 +893,16 @@ def configure_step(self):
 
         # If 'ON', risk finding a system zlib or zstd leading to including /usr/include as -isystem that can lead
         # to errors during compilation of 'offload.tools.kernelreplay' due to the inclusion of LLVMSupport (19.x)
-        self.general_opts['LLVM_ENABLE_ZLIB'] = 'ON' if get_software_root('zlib') else 'OFF'
-        self.general_opts['LLVM_ENABLE_ZSTD'] = 'ON' if get_software_root('zstd') else 'OFF'
+        self.general_opts['LLVM_ENABLE_ZLIB'] = 'ON' if 'zlib' in self.deps else 'OFF'
+        self.general_opts['LLVM_ENABLE_ZSTD'] = 'ON' if 'zstd' in self.deps else 'OFF'
         # Should not use system SWIG if present
-        self.general_opts['LLDB_ENABLE_SWIG'] = 'ON' if get_software_root('SWIG') else 'OFF'
+        self.general_opts['LLDB_ENABLE_SWIG'] = 'ON' if 'swig' in self.deps else 'OFF'
 
         # Avoid using system `gdb` in case it is not provided as a dependency
         # This could cause the wrong sysroot/dynamic linker being picked up in a sysroot build causing tests to fail
-        self.general_opts['LIBOMP_OMPD_GDB_SUPPORT'] = 'ON' if get_software_root('GDB') else 'OFF'
+        self.general_opts['LIBOMP_OMPD_GDB_SUPPORT'] = 'ON' if 'gdb' in self.deps else 'OFF'
 
-        z3_root = get_software_root("Z3")
+        z3_root = self.get_dependency_root("Z3")
         if z3_root:
             self.log.info("Using %s as Z3 root", z3_root)
             self.general_opts['LLVM_ENABLE_Z3_SOLVER'] = 'ON'
@@ -947,7 +951,7 @@ def configure_step(self):
         # If we don't want to build with CUDA (not in dependencies) trick CMakes FindCUDA module into not finding it by
         # using the environment variable which is used as-is and later checked for a falsy value when determining
         # whether CUDA was found
-        if not get_software_root('CUDA'):
+        if 'cuda' not in self.deps:
             setvar('CUDA_NVCC_EXECUTABLE', 'IGNORE')
 
         # 20.1+ uses a generic IR for OpenMP DeviceRTL
@@ -1000,6 +1004,8 @@ def disable_sanitizer_tests(self):
         cmakelists_tests = os.path.join(self.start_dir, 'compiler-rt', 'test', 'CMakeLists.txt')
         regex_subs = [(r'compiler_rt_test_runtime.*san.*', '')]
         apply_regex_substitutions(cmakelists_tests, regex_subs)
+        if LooseVersion(self.version) >= '20.1.0':
+            self.general_opts['OPENMP_TEST_ENABLE_TSAN'] = 'OFF'
 
     def add_cmake_opts(self):
         """Add LLVM-specific CMake options."""