diff --git a/easybuild/easyblocks/x/xmipp.py b/easybuild/easyblocks/x/xmipp.py
index c84a43a50f1..122c49543b6 100644
--- a/easybuild/easyblocks/x/xmipp.py
+++ b/easybuild/easyblocks/x/xmipp.py
@@ -101,10 +101,15 @@ def configure_step(self):
         # Tell xmipp config that there is no Scipion.
         env.setvar('XMIPP_NOSCIPION', 'True')
         # Initialize the config file and then patch it with the correct values
+        if LooseVersion(self.version) >= LooseVersion('3.20.07'):
+            noask = 'noAsk'
+        else:
+            noask = ''
         cmd = ' '.join([
             self.cfg['preconfigopts'],
             self.xmipp_exe,
             'config',
+            noask,
             self.cfg['configopts'],
         ])
         run_cmd(cmd, log_all=True, simple=True)