diff --git a/bench/abc/optimized/abcDfs.ll b/bench/abc/optimized/abcDfs.ll
index e2a6f3fc5c0..0d8ffbbd605 100644
--- a/bench/abc/optimized/abcDfs.ll
+++ b/bench/abc/optimized/abcDfs.ll
@@ -12073,8 +12073,7 @@ Abc_NtkIncrementTravId.exit:                      ; preds = %Vec_IntGrow.exit.i.
   %26 = load i32, ptr %25, align 8, !tbaa !14
   %27 = add nsw i32 %26, 1
   store i32 %27, ptr %25, align 8, !tbaa !14
-  %.not.i20 = icmp ne ptr %.pr43, null
-  tail call void @llvm.assume(i1 %.not.i20)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pr43) ]
   br label %Abc_NtkIncrementTravId.exit27
 
 Abc_NtkIncrementTravId.exit.thread40:             ; preds = %Vec_IntGrow.exit.i.i
diff --git a/bench/abseil-cpp/optimized/cordz_info_test.ll b/bench/abseil-cpp/optimized/cordz_info_test.ll
index 2e878bea1a4..bf9e2deadd8 100644
--- a/bench/abseil-cpp/optimized/cordz_info_test.ll
+++ b/bench/abseil-cpp/optimized/cordz_info_test.ll
@@ -16852,6 +16852,7 @@ define internal void @_ZN4absl13cord_internal12_GLOBAL__N_129CordzInfoTest_RefCo
   br i1 %.not.i, label %34, label %31
 
 31:                                               ; preds = %.noexc
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %30) ]
   %32 = getelementptr inbounds nuw i8, ptr %30, i64 8
   %33 = atomicrmw add ptr %32, i32 2 monotonic, align 4
   br label %34
diff --git a/bench/actix-rs/optimized/48duj8tg7v09rmpe.ll b/bench/actix-rs/optimized/48duj8tg7v09rmpe.ll
index 74b0186383e..8d8e7feda47 100644
--- a/bench/actix-rs/optimized/48duj8tg7v09rmpe.ll
+++ b/bench/actix-rs/optimized/48duj8tg7v09rmpe.ll
@@ -736,19 +736,18 @@ define hidden void @_ZN9rand_core11SeedableRng8from_rng17hf872c3ee3795dc0dE(ptr
   %10 = getelementptr inbounds nuw i8, ptr %0, i64 16
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 16 dereferenceable(48) %10, ptr noundef nonnull align 16 dereferenceable(48) %.sroa.0, i64 48, i1 false)
   call void @llvm.lifetime.end.p0(ptr nonnull %.sroa.0)
-  br label %16
+  br label %15
 
 11:                                               ; preds = %2
   %12 = extractvalue { ptr, ptr } %5, 1
-  %13 = icmp ne ptr %12, null
-  call void @llvm.assume(i1 %13)
-  %14 = getelementptr inbounds nuw i8, ptr %0, i64 8
-  store ptr %6, ptr %14, align 8
-  %15 = getelementptr inbounds nuw i8, ptr %0, i64 16
-  store ptr %12, ptr %15, align 16
-  br label %16
-
-16:                                               ; preds = %11, %8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %12) ]
+  %13 = getelementptr inbounds nuw i8, ptr %0, i64 8
+  store ptr %6, ptr %13, align 8
+  %14 = getelementptr inbounds nuw i8, ptr %0, i64 16
+  store ptr %12, ptr %14, align 16
+  br label %15
+
+15:                                               ; preds = %11, %8
   %.sink = phi i64 [ 0, %8 ], [ 1, %11 ]
   call void @llvm.lifetime.end.p0(ptr nonnull %4)
   store i64 %.sink, ptr %0, align 16
diff --git a/bench/actix-rs/optimized/4pry3bojy1efv3uz.ll b/bench/actix-rs/optimized/4pry3bojy1efv3uz.ll
index efdbc49f37e..371e43eb12e 100644
--- a/bench/actix-rs/optimized/4pry3bojy1efv3uz.ll
+++ b/bench/actix-rs/optimized/4pry3bojy1efv3uz.ll
@@ -209,6 +209,7 @@ define hidden noundef ptr @"_ZN91_$LT$hashbrown..raw..RawIter$LT$T$GT$$u20$as$u2
   %.val911.i = phi ptr [ %.promoted.i, %.lr.ph.i ], [ %13, %9 ]
   %11 = load <16 x i8>, ptr %10, align 16, !noalias !31
   %12 = icmp sgt <16 x i8> %11, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911.i) ]
   %13 = getelementptr inbounds i8, ptr %.val911.i, i64 -384
   %14 = getelementptr inbounds nuw i8, ptr %10, i64 16
   %.cast.i = bitcast <16 x i1> %12 to i16
@@ -223,6 +224,7 @@ define hidden noundef ptr @"_ZN91_$LT$hashbrown..raw..RawIter$LT$T$GT$$u20$as$u2
   %17 = add i16 %.lcssa.i, -1
   %18 = and i16 %17, %.lcssa.i
   store i16 %18, ptr %6, align 8, !alias.scope !28
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3.i) ]
   %19 = sub nsw i64 0, %16
   %20 = getelementptr inbounds { { { { { ptr, i64 } }, {}, {} } }, i32, [1 x i32] }, ptr %.val3.i, i64 %19
   %21 = add i64 %3, -1
@@ -264,6 +266,7 @@ define hidden noundef ptr @"_ZN91_$LT$hashbrown..raw..RawIter$LT$T$GT$$u20$as$u2
   %.val911.i = phi ptr [ %.promoted.i, %.lr.ph.i ], [ %13, %9 ]
   %11 = load <16 x i8>, ptr %10, align 16, !noalias !40
   %12 = icmp sgt <16 x i8> %11, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911.i) ]
   %13 = getelementptr inbounds i8, ptr %.val911.i, i64 -384
   %14 = getelementptr inbounds nuw i8, ptr %10, i64 16
   %.cast.i = bitcast <16 x i1> %12 to i16
@@ -278,6 +281,7 @@ define hidden noundef ptr @"_ZN91_$LT$hashbrown..raw..RawIter$LT$T$GT$$u20$as$u2
   %17 = add i16 %.lcssa.i, -1
   %18 = and i16 %17, %.lcssa.i
   store i16 %18, ptr %6, align 8, !alias.scope !37
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3.i) ]
   %19 = sub nsw i64 0, %16
   %20 = getelementptr inbounds { { { { ptr, i64 } }, {}, {} }, i32, [1 x i32] }, ptr %.val3.i, i64 %19
   %21 = add i64 %3, -1
@@ -410,6 +414,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner13drop_elements17h9fe04f5422
   %.val911.i.i = phi ptr [ %15, %.lr.ph.i.i ], [ %.sroa.03.018, %11 ]
   %13 = load <16 x i8>, ptr %12, align 16, !noalias !48
   %14 = icmp sgt <16 x i8> %13, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911.i.i) ]
   %15 = getelementptr inbounds i8, ptr %.val911.i.i, i64 -384
   %16 = getelementptr inbounds nuw i8, ptr %12, i64 16
   %.cast.i.i = bitcast <16 x i1> %14 to i16
@@ -422,6 +427,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner13drop_elements17h9fe04f5422
   %.lcssa.i.i = phi i16 [ %.sroa.84.015, %11 ], [ %.cast.i.i, %.lr.ph.i.i ]
   %17 = add i16 %.lcssa.i.i, -1
   %18 = and i16 %17, %.lcssa.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.03.1) ]
   %19 = add i64 %.sroa.105.016, -1
   %20 = tail call range(i16 0, 17) i16 @llvm.cttz.i16(i16 %.lcssa.i.i, i1 true)
   %21 = zext nneg i16 %20 to i64
@@ -478,6 +484,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner13drop_elements17hd32faf45f1
   %.val911.i.i = phi ptr [ %15, %.lr.ph.i.i ], [ %.sroa.03.018, %11 ]
   %13 = load <16 x i8>, ptr %12, align 16, !noalias !77
   %14 = icmp sgt <16 x i8> %13, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911.i.i) ]
   %15 = getelementptr inbounds i8, ptr %.val911.i.i, i64 -384
   %16 = getelementptr inbounds nuw i8, ptr %12, i64 16
   %.cast.i.i = bitcast <16 x i1> %14 to i16
@@ -490,6 +497,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner13drop_elements17hd32faf45f1
   %.lcssa.i.i = phi i16 [ %.sroa.84.015, %11 ], [ %.cast.i.i, %.lr.ph.i.i ]
   %17 = add i16 %.lcssa.i.i, -1
   %18 = and i16 %17, %.lcssa.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.03.1) ]
   %19 = add i64 %.sroa.105.016, -1
   %20 = tail call range(i16 0, 17) i16 @llvm.cttz.i16(i16 %.lcssa.i.i, i1 true)
   %21 = zext nneg i16 %20 to i64
@@ -549,6 +557,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner16drop_inner_table17h783e215
   %.val911.i.i.i = phi ptr [ %22, %.lr.ph.i.i.i ], [ %.sroa.03.018.i, %18 ]
   %20 = load <16 x i8>, ptr %19, align 16, !noalias !106
   %21 = icmp sgt <16 x i8> %20, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911.i.i.i) ]
   %22 = getelementptr inbounds i8, ptr %.val911.i.i.i, i64 -384
   %23 = getelementptr inbounds nuw i8, ptr %19, i64 16
   %.cast.i.i.i = bitcast <16 x i1> %21 to i16
@@ -561,6 +570,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner16drop_inner_table17h783e215
   %.lcssa.i.i.i = phi i16 [ %.sroa.84.015.i, %18 ], [ %.cast.i.i.i, %.lr.ph.i.i.i ]
   %24 = add i16 %.lcssa.i.i.i, -1
   %25 = and i16 %24, %.lcssa.i.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.03.1.i) ]
   %26 = add i64 %.sroa.105.016.i, -1
   %27 = tail call range(i16 0, 17) i16 @llvm.cttz.i16(i16 %.lcssa.i.i.i, i1 true)
   %28 = zext nneg i16 %27 to i64
@@ -650,6 +660,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner16drop_inner_table17ha9ab62d
   %.val911.i.i.i = phi ptr [ %22, %.lr.ph.i.i.i ], [ %.sroa.03.018.i, %18 ]
   %20 = load <16 x i8>, ptr %19, align 16, !noalias !138
   %21 = icmp sgt <16 x i8> %20, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911.i.i.i) ]
   %22 = getelementptr inbounds i8, ptr %.val911.i.i.i, i64 -384
   %23 = getelementptr inbounds nuw i8, ptr %19, i64 16
   %.cast.i.i.i = bitcast <16 x i1> %21 to i16
@@ -662,6 +673,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner16drop_inner_table17ha9ab62d
   %.lcssa.i.i.i = phi i16 [ %.sroa.84.015.i, %18 ], [ %.cast.i.i.i, %.lr.ph.i.i.i ]
   %24 = add i16 %.lcssa.i.i.i, -1
   %25 = and i16 %24, %.lcssa.i.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.03.1.i) ]
   %26 = add i64 %.sroa.105.016.i, -1
   %27 = tail call range(i16 0, 17) i16 @llvm.cttz.i16(i16 %.lcssa.i.i.i, i1 true)
   %28 = zext nneg i16 %27 to i64
@@ -806,7 +818,7 @@ define hidden void @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$3new17ha6e269db982b
   ret void
 }
 
-; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable
+; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: write, target_mem0: none, target_mem1: none) uwtable
 define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9next_impl17h36e548844c8f16f9E.llvm.8051598444039092977"(ptr noalias noundef align 8 captures(none) dereferenceable(32) %0) unnamed_addr #11 {
   %2 = getelementptr inbounds nuw i8, ptr %0, i64 24
   %3 = load i16, ptr %2, align 8, !alias.scope !194, !noundef !11
@@ -832,6 +844,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   %7 = add i16 %.lcssa, -1
   %8 = and i16 %7, %.lcssa
   store i16 %8, ptr %2, align 8, !alias.scope !194
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3) ]
   %9 = sub nsw i64 0, %6
   %10 = getelementptr inbounds { { { { { ptr, i64 } }, {}, {} } }, i32, [1 x i32] }, ptr %.val3, i64 %9
   ret ptr %10
@@ -841,6 +854,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   %.val911 = phi ptr [ %.promoted, %.lr.ph ], [ %15, %11 ]
   %13 = load <16 x i8>, ptr %12, align 16, !noalias !197
   %14 = icmp sgt <16 x i8> %13, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911) ]
   %15 = getelementptr inbounds i8, ptr %.val911, i64 -384
   %16 = getelementptr inbounds nuw i8, ptr %12, i64 16
   %.cast = bitcast <16 x i1> %14 to i16
@@ -848,7 +862,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   br i1 %.not.i, label %11, label %._crit_edge
 }
 
-; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable
+; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: write, target_mem0: none, target_mem1: none) uwtable
 define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9next_impl17hd4f32f52198b99c9E.llvm.8051598444039092977"(ptr noalias noundef align 8 captures(none) dereferenceable(32) %0) unnamed_addr #11 {
   %2 = getelementptr inbounds nuw i8, ptr %0, i64 24
   %3 = load i16, ptr %2, align 8, !alias.scope !200, !noundef !11
@@ -874,6 +888,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   %7 = add i16 %.lcssa, -1
   %8 = and i16 %7, %.lcssa
   store i16 %8, ptr %2, align 8, !alias.scope !200
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3) ]
   %9 = sub nsw i64 0, %6
   %10 = getelementptr inbounds { { { { ptr, i64 } }, {}, {} }, i32, [1 x i32] }, ptr %.val3, i64 %9
   ret ptr %10
@@ -883,6 +898,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   %.val911 = phi ptr [ %.promoted, %.lr.ph ], [ %15, %11 ]
   %13 = load <16 x i8>, ptr %12, align 16, !noalias !203
   %14 = icmp sgt <16 x i8> %13, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911) ]
   %15 = getelementptr inbounds i8, ptr %.val911, i64 -384
   %16 = getelementptr inbounds nuw i8, ptr %12, i64 16
   %.cast = bitcast <16 x i1> %14 to i16
@@ -937,7 +953,7 @@ attributes #7 = { nofree norecurse nosync nounwind nonlazybind memory(read, argm
 attributes #8 = { inlinehint mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: write, inaccessiblemem: write) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #9 = { inlinehint mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #10 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: readwrite) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #11 = { nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #11 = { nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: write, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #12 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #13 = { mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
 attributes #14 = { nounwind nonlazybind allockind("free") uwtable "alloc-family"="__rust_alloc" "probe-stack"="inline-asm" "target-cpu"="x86-64" }
diff --git a/bench/actix-rs/optimized/5a33a9xfp20c1mrr.ll b/bench/actix-rs/optimized/5a33a9xfp20c1mrr.ll
index bd39560b506..f899aa5bc39 100644
--- a/bench/actix-rs/optimized/5a33a9xfp20c1mrr.ll
+++ b/bench/actix-rs/optimized/5a33a9xfp20c1mrr.ll
@@ -898,12 +898,14 @@ define hidden void @"_ZN4core3ptr87drop_in_place$LT$alloc..boxed..Box$LT$actix_h
   br label %"_ZN4core3ptr62drop_in_place$LT$actix_http..responses..head..ResponseHead$GT$17hb692267e8bc8925aE.exit"
 
 "_ZN4core3ptr62drop_in_place$LT$actix_http..responses..head..ResponseHead$GT$17hb692267e8bc8925aE.exit": ; preds = %17, %.noexc2, %1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %3, i64 noundef 88, i64 noundef 8) #15
   ret void
 
 21:                                               ; preds = %7, %.noexc
   %22 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %3, i64 noundef 88, i64 noundef 8) #15
   resume { ptr, i32 } %22
 }
@@ -1119,6 +1121,7 @@ common.resume:                                    ; preds = %"_ZN4core3ptr53drop
   %36 = load ptr, ptr %35, align 8, !nonnull !12, !noundef !12
   %37 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %38 = load i64, ptr %37, align 8, !noundef !12
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %36) ]
   br label %"_ZN4core3ptr53drop_in_place$LT$http..header..value..HeaderValue$GT$17h4e02beeeadfaa177E.exit.i.i.i"
 
 "_ZN4core3ptr53drop_in_place$LT$http..header..value..HeaderValue$GT$17h4e02beeeadfaa177E.exit.i.i.i": ; preds = %40, %34
@@ -1178,11 +1181,13 @@ common.resume:                                    ; preds = %"_ZN4core3ptr53drop
 
 "_ZN4core3ptr83drop_in_place$LT$alloc..raw_vec..RawVec$LT$http..header..value..HeaderValue$GT$$GT$17h8502e2220a3850a7E.exit.i": ; preds = %"_ZN4core3ptr53drop_in_place$LT$http..header..value..HeaderValue$GT$17h4e02beeeadfaa177E.exit7.i.i.i"
   %67 = mul nuw i64 %3, 40
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %36) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %36, i64 noundef %67, i64 noundef 8) #15, !noalias !323
   br label %common.resume
 
 "_ZN4core3ptr76drop_in_place$LT$alloc..vec..Vec$LT$http..header..value..HeaderValue$GT$$GT$17hf2cc884ef86a95e8E.exit": ; preds = %"_ZN4core3ptr53drop_in_place$LT$http..header..value..HeaderValue$GT$17h4e02beeeadfaa177E.exit.i.i.i"
   %68 = mul nuw i64 %3, 40
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %36) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %36, i64 noundef %68, i64 noundef 8) #15, !noalias !323
   br label %"_ZN4core3ptr63drop_in_place$LT$$u5b$http..header..value..HeaderValue$u5d$$GT$17h3bb6985a81f3dda2E.exit"
 
diff --git a/bench/actix-rs/optimized/83dw2wnqoscdmtc.ll b/bench/actix-rs/optimized/83dw2wnqoscdmtc.ll
index e39785b0a8a..e797c5f7bde 100644
--- a/bench/actix-rs/optimized/83dw2wnqoscdmtc.ll
+++ b/bench/actix-rs/optimized/83dw2wnqoscdmtc.ll
@@ -161,8 +161,7 @@ define hidden void @"_ZN5alloc3str56_$LT$impl$u20$alloc..borrow..ToOwned$u20$for
   %4 = tail call { i64, ptr } @"_ZN5alloc7raw_vec19RawVec$LT$T$C$A$GT$11allocate_in17h7aa9cb48765920a8E"(i64 noundef %2, i1 noundef zeroext false)
   %5 = extractvalue { i64, ptr } %4, 0
   %6 = extractvalue { i64, ptr } %4, 1
-  %7 = icmp ne ptr %6, null
-  tail call void @llvm.assume(i1 %7)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
   tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %6, ptr nonnull align 1 %1, i64 %2, i1 false)
   store i64 %5, ptr %0, align 8
   %.sroa.42.0..sroa_idx = getelementptr inbounds nuw i8, ptr %0, i64 8
@@ -187,8 +186,7 @@ define hidden void @"_ZN5alloc6borrow12Cow$LT$B$GT$10into_owned17h84efa79208c010
   %10 = tail call { i64, ptr } @"_ZN5alloc7raw_vec19RawVec$LT$T$C$A$GT$11allocate_in17h7aa9cb48765920a8E"(i64 noundef %9, i1 noundef zeroext false), !noalias !29
   %11 = extractvalue { i64, ptr } %10, 0
   %12 = extractvalue { i64, ptr } %10, 1
-  %13 = icmp ne ptr %12, null
-  tail call void @llvm.assume(i1 %13)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %12) ]
   tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %12, ptr nonnull readonly align 1 %7, i64 %9, i1 false), !noalias !26
   store i64 %11, ptr %0, align 8, !alias.scope !26, !noalias !31
   %.sroa.42.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %0, i64 8
diff --git a/bench/anki-rs/optimized/2lb7ct7ebbwm4pw.ll b/bench/anki-rs/optimized/2lb7ct7ebbwm4pw.ll
index 384f4da9507..e809e1a0112 100644
--- a/bench/anki-rs/optimized/2lb7ct7ebbwm4pw.ll
+++ b/bench/anki-rs/optimized/2lb7ct7ebbwm4pw.ll
@@ -199,7 +199,7 @@ define void @"_ZN111_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..spec_fr
   %15 = landingpad { ptr, i32 }
           cleanup
   invoke void @"_ZN4core3ptr43drop_in_place$LT$anki_proto_gen..Method$GT$17haf41f5eb221c3047E"(ptr nonnull align 8 %5) #15
-          to label %30 unwind label %28
+          to label %29 unwind label %28
 
 16:                                               ; preds = %12
   %17 = load i64, ptr %4, align 8, !noundef !3
@@ -214,8 +214,7 @@ define void @"_ZN111_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..spec_fr
 22:                                               ; preds = %20
   %23 = extractvalue { ptr, i64 } %21, 0
   %24 = extractvalue { ptr, i64 } %21, 1
-  %25 = icmp ne ptr %23, null
-  call void @llvm.assume(i1 %25)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %23) ]
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(80) %23, ptr noundef nonnull align 8 dereferenceable(80) %5, i64 80, i1 false)
   store ptr %23, ptr %7, align 8
   %.sroa.3.0..sroa_idx = getelementptr inbounds nuw i8, ptr %7, i64 8
@@ -230,7 +229,7 @@ define void @"_ZN111_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..spec_fr
   %27 = landingpad { ptr, i32 }
           cleanup
   invoke void @"_ZN4core3ptr66drop_in_place$LT$alloc..vec..Vec$LT$anki_proto_gen..Method$GT$$GT$17hfc18336c487e1317E"(ptr nonnull align 8 %7) #15
-          to label %30 unwind label %28
+          to label %29 unwind label %28
 
 "_ZN97_$LT$alloc..vec..Vec$LT$T$C$A$GT$$u20$as$u20$alloc..vec..spec_extend..SpecExtend$LT$T$C$I$GT$$GT$11spec_extend17hc5d14f68e06a7c8bE.exit": ; preds = %22
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %0, ptr noundef nonnull align 8 dereferenceable(24) %7, i64 24, i1 false)
@@ -243,7 +242,7 @@ define void @"_ZN111_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..spec_fr
   unreachable
 
 30:                                               ; preds = %26, %14
-  %.pn = phi { ptr, i32 } [ %27, %26 ], [ %15, %14 ]
+  %.pn = phi { ptr, i32 } [ %27, %25 ], [ %15, %14 ]
   resume { ptr, i32 } %.pn
 }
 
@@ -264,25 +263,23 @@ define align 8 ptr @"_ZN51_$LT$T$u20$as$u20$core..borrow..Borrow$LT$T$GT$$GT$6bo
 }
 
 ; Function Attrs: nonlazybind uwtable
-define zeroext i1 @"_ZN52_$LT$Q$u20$as$u20$hashbrown..Equivalent$LT$K$GT$$GT$10equivalent17h5b147a3dd44ec57eE"(ptr readonly align 8 captures(address_is_null) %0, ptr readonly align 8 captures(address_is_null) %1) unnamed_addr #1 personality ptr @rust_eh_personality {
-  %3 = icmp ne ptr %0, null
-  tail call void @llvm.assume(i1 %3)
-  %4 = icmp ne ptr %1, null
-  tail call void @llvm.assume(i1 %4)
-  %5 = load ptr, ptr %0, align 8, !nonnull !3, !noundef !3
-  %6 = getelementptr inbounds nuw i8, ptr %0, i64 16
-  %7 = load i64, ptr %6, align 8, !noundef !3
-  %8 = tail call { ptr, i64 } @"_ZN97_$LT$core..ops..range..RangeFull$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h0401ead8792c88f5E"(ptr nonnull align 4 %5, i64 %7, ptr nonnull align 8 @anon.d8650f252a778334d2c694542707141d.10)
-  %9 = extractvalue { ptr, i64 } %8, 0
-  %10 = extractvalue { ptr, i64 } %8, 1
-  %11 = load ptr, ptr %1, align 8, !nonnull !3, !noundef !3
-  %12 = getelementptr inbounds nuw i8, ptr %1, i64 16
-  %13 = load i64, ptr %12, align 8, !noundef !3
-  %14 = tail call { ptr, i64 } @"_ZN97_$LT$core..ops..range..RangeFull$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h0401ead8792c88f5E"(ptr nonnull align 4 %11, i64 %13, ptr nonnull align 8 @anon.d8650f252a778334d2c694542707141d.10)
-  %15 = extractvalue { ptr, i64 } %14, 0
-  %16 = extractvalue { ptr, i64 } %14, 1
-  %17 = tail call zeroext i1 @"_ZN73_$LT$$u5b$A$u5d$$u20$as$u20$core..slice..cmp..SlicePartialEq$LT$B$GT$$GT$5equal17h1b295f8517b8ca3bE"(ptr align 4 %9, i64 %10, ptr align 4 %15, i64 %16)
-  ret i1 %17
+define zeroext i1 @"_ZN52_$LT$Q$u20$as$u20$hashbrown..Equivalent$LT$K$GT$$GT$10equivalent17h5b147a3dd44ec57eE"(ptr readonly align 8 captures(none) %0, ptr readonly align 8 captures(none) %1) unnamed_addr #1 personality ptr @rust_eh_personality {
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
+  %3 = load ptr, ptr %0, align 8, !nonnull !3, !noundef !3
+  %4 = getelementptr inbounds nuw i8, ptr %0, i64 16
+  %5 = load i64, ptr %4, align 8, !noundef !3
+  %6 = tail call { ptr, i64 } @"_ZN97_$LT$core..ops..range..RangeFull$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h0401ead8792c88f5E"(ptr nonnull align 4 %3, i64 %5, ptr nonnull align 8 @anon.d8650f252a778334d2c694542707141d.10)
+  %7 = extractvalue { ptr, i64 } %6, 0
+  %8 = extractvalue { ptr, i64 } %6, 1
+  %9 = load ptr, ptr %1, align 8, !nonnull !3, !noundef !3
+  %10 = getelementptr inbounds nuw i8, ptr %1, i64 16
+  %11 = load i64, ptr %10, align 8, !noundef !3
+  %12 = tail call { ptr, i64 } @"_ZN97_$LT$core..ops..range..RangeFull$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h0401ead8792c88f5E"(ptr nonnull align 4 %9, i64 %11, ptr nonnull align 8 @anon.d8650f252a778334d2c694542707141d.10)
+  %13 = extractvalue { ptr, i64 } %12, 0
+  %14 = extractvalue { ptr, i64 } %12, 1
+  %15 = tail call zeroext i1 @"_ZN73_$LT$$u5b$A$u5d$$u20$as$u20$core..slice..cmp..SlicePartialEq$LT$B$GT$$GT$5equal17h1b295f8517b8ca3bE"(ptr align 4 %7, i64 %8, ptr align 4 %13, i64 %14)
+  ret i1 %15
 }
 
 ; Function Attrs: inlinehint nonlazybind uwtable
diff --git a/bench/anki-rs/optimized/yhvjx27msub7381.ll b/bench/anki-rs/optimized/yhvjx27msub7381.ll
index ca0183b2c52..5bd40f17304 100644
--- a/bench/anki-rs/optimized/yhvjx27msub7381.ll
+++ b/bench/anki-rs/optimized/yhvjx27msub7381.ll
@@ -11,22 +11,23 @@ target triple = "x86_64-unknown-linux-gnu"
 @anon.1fd0f21b59ebd390a4b6844ce9c4a3aa.5 = private unnamed_addr constant <{ ptr, [16 x i8] }> <{ ptr @anon.1fd0f21b59ebd390a4b6844ce9c4a3aa.4, [16 x i8] c"\1A\00\00\00\00\00\00\00\F2\00\00\00I\00\00\00" }>, align 8
 
 ; Function Attrs: nonlazybind uwtable
-define zeroext i1 @"_ZN4core3ops8function5impls79_$LT$impl$u20$core..ops..function..FnMut$LT$A$GT$$u20$for$u20$$RF$mut$u20$F$GT$8call_mut17h39c9d34820ec298aE"(ptr readonly align 8 captures(none) %0, ptr readonly align 8 captures(address_is_null) %1) unnamed_addr #0 {
+define zeroext i1 @"_ZN4core3ops8function5impls79_$LT$impl$u20$core..ops..function..FnMut$LT$A$GT$$u20$for$u20$$RF$mut$u20$F$GT$8call_mut17h39c9d34820ec298aE"(ptr readonly align 8 captures(none) %0, ptr readonly align 8 captures(none) %1) unnamed_addr #0 {
   %3 = alloca { ptr, ptr }, align 8
   %4 = load ptr, ptr %0, align 8, !nonnull !3, !align !4, !noundef !3
-  %5 = icmp ne ptr %1, null
-  tail call void @llvm.assume(i1 %5)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val = load ptr, ptr %4, align 8, !nonnull !3, !align !4, !noundef !3
   %.val1 = load ptr, ptr %1, align 8, !nonnull !3, !align !4, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %3)
-  %6 = load ptr, ptr %.val, align 8, !nonnull !3, !noundef !3
-  %7 = getelementptr inbounds nuw i8, ptr %.val, i64 16
-  %8 = load i64, ptr %7, align 8, !noundef !3
-  %9 = getelementptr inbounds { { { { ptr, i64 }, i64 } }, { { ptr, i32 }, i32, [1 x i32] }, i64, { ptr, [2 x i64] } }, ptr %6, i64 %8
-  store ptr %6, ptr %3, align 8
-  %10 = getelementptr inbounds nuw i8, ptr %3, i64 8
-  store ptr %9, ptr %10, align 8
-  %11 = call zeroext i1 @"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$3all17hb844b111d5be2405E"(ptr nonnull align 8 %3, ptr nonnull align 8 %.val1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  %5 = load ptr, ptr %.val, align 8, !nonnull !3, !noundef !3
+  %6 = getelementptr inbounds nuw i8, ptr %.val, i64 16
+  %7 = load i64, ptr %6, align 8, !noundef !3
+  %8 = getelementptr inbounds { { { { ptr, i64 }, i64 } }, { { ptr, i32 }, i32, [1 x i32] }, i64, { ptr, [2 x i64] } }, ptr %5, i64 %7
+  store ptr %5, ptr %3, align 8
+  %9 = getelementptr inbounds nuw i8, ptr %3, i64 8
+  store ptr %8, ptr %9, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1) ]
+  %10 = call zeroext i1 @"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$3all17hb844b111d5be2405E"(ptr nonnull align 8 %3, ptr nonnull align 8 %.val1)
   call void @llvm.lifetime.end.p0(ptr nonnull %3)
   ret i1 %11
 }
@@ -34,20 +35,20 @@ define zeroext i1 @"_ZN4core3ops8function5impls79_$LT$impl$u20$core..ops..functi
 ; Function Attrs: nonlazybind uwtable
 define void @"_ZN4core3ops8function5impls80_$LT$impl$u20$core..ops..function..FnOnce$LT$A$GT$$u20$for$u20$$RF$mut$u20$F$GT$9call_once17hab7d47256a5fe88aE"(ptr writeonly sret({ { { { ptr, i64 }, i64 } }, { { ptr, i32 }, i32, [1 x i32] }, i64, { ptr, [2 x i64] } }) align 8 captures(none) initializes((0, 80)) %0, ptr readonly align 8 captures(none) %1, ptr align 8 %2) unnamed_addr #0 {
   %4 = alloca { { { { ptr, i64 }, i64 } }, { { ptr, i32 }, i32, [1 x i32] }, i64, { ptr, [2 x i64] } }, align 8
-  %5 = icmp ne ptr %2, null
-  tail call void @llvm.assume(i1 %5)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   %.val = load ptr, ptr %1, align 8, !nonnull !3, !align !4, !noundef !3
   tail call void @llvm.experimental.noalias.scope.decl(metadata !5)
   call void @llvm.lifetime.start.p0(ptr nonnull %4)
   %6 = getelementptr inbounds nuw i8, ptr %2, i64 48
   %7 = load i64, ptr %6, align 8, !noalias !5, !noundef !3
-  %8 = getelementptr inbounds nuw i8, ptr %.val, i64 16
-  %9 = load i64, ptr %8, align 8, !noalias !5, !noundef !3
-  %10 = add i64 %9, %7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  %7 = getelementptr inbounds nuw i8, ptr %.val, i64 16
+  %8 = load i64, ptr %7, align 8, !noalias !5, !noundef !3
+  %9 = add i64 %8, %6
   call void @"_ZN61_$LT$anki_proto_gen..Method$u20$as$u20$core..clone..Clone$GT$5clone17had7f047f5d3ae9d5E"(ptr nonnull sret({ { { { ptr, i64 }, i64 } }, { { ptr, i32 }, i32, [1 x i32] }, i64, { ptr, [2 x i64] } }) align 8 %4, ptr nonnull align 8 %2), !noalias !5
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %0, ptr noundef nonnull align 8 dereferenceable(24) %4, i64 24, i1 false)
   %11 = getelementptr inbounds nuw i8, ptr %0, i64 48
-  store i64 %10, ptr %11, align 8, !alias.scope !5
+  store i64 %9, ptr %11, align 8, !alias.scope !5
   %12 = getelementptr inbounds nuw i8, ptr %4, i64 56
   %13 = getelementptr inbounds nuw i8, ptr %0, i64 56
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %13, ptr noundef nonnull align 8 dereferenceable(24) %12, i64 24, i1 false)
diff --git a/bench/boost/optimized/target.ll b/bench/boost/optimized/target.ll
index 24d79722dd0..0561bc99f42 100644
--- a/bench/boost/optimized/target.ll
+++ b/bench/boost/optimized/target.ll
@@ -10713,14 +10713,12 @@ _ZNKSt9type_infoeqERKS_.exit.i8:                  ; preds = %_ZNK5boost4asio9exe
 
 _ZNK5boost4asio9execution6detail17any_executor_base6targetINS0_10io_context19basic_executor_typeISaIvELm0EEEEEPKT_v.exit12: ; preds = %_ZNKSt9type_infoeqERKS_.exit.thread.i11, %_ZNKSt9type_infoeqERKS_.exit.i8
   %32 = phi ptr [ %28, %_ZNKSt9type_infoeqERKS_.exit.thread.i11 ], [ %spec.select.i10, %_ZNKSt9type_infoeqERKS_.exit.i8 ]
-  %33 = icmp ne ptr %19, null
-  tail call void @llvm.assume(i1 %33)
-  %34 = icmp ne ptr %32, null
-  tail call void @llvm.assume(i1 %34)
-  %35 = load i64, ptr %19, align 8, !tbaa !81
-  %36 = load i64, ptr %32, align 8, !tbaa !81
-  %37 = icmp eq i64 %35, %36
-  ret i1 %37
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %19) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %33) ]
+  %34 = load i64, ptr %19, align 8, !tbaa !81
+  %34 = load i64, ptr %32, align 8, !tbaa !81
+  %35 = icmp eq i64 %33, %34
+  ret i1 %35
 }
 
 ; Function Attrs: mustprogress uwtable
@@ -10749,8 +10747,7 @@ _ZNKSt9type_infoeqERKS_.exit.i:                   ; preds = %2
 
 _ZNK5boost4asio9execution6detail17any_executor_base6targetINS0_10io_context19basic_executor_typeISaIvELm0EEEEEPKT_v.exit: ; preds = %_ZNKSt9type_infoeqERKS_.exit.thread.i, %_ZNKSt9type_infoeqERKS_.exit.i
   %15 = phi ptr [ %11, %_ZNKSt9type_infoeqERKS_.exit.thread.i ], [ %spec.select.i, %_ZNKSt9type_infoeqERKS_.exit.i ]
-  %16 = icmp ne ptr %15, null
-  tail call void @llvm.assume(i1 %16)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %15) ]
   tail call void @_ZNK5boost4asio10io_context19basic_executor_typeISaIvELm0EE7executeINS0_6detail17executor_functionEEEvOT_(ptr noundef nonnull align 8 dereferenceable(8) %15, ptr noundef nonnull align 8 dereferenceable(8) %1)
   ret void
 }
@@ -11777,8 +11774,7 @@ define linkonce_odr hidden void @_ZN5boost10wrapexceptISt9bad_allocEC2ERKS2_(ptr
 define linkonce_odr hidden void @_ZN5boost4asio6detail11executor_opINS1_17executor_functionESaIvENS1_19scheduler_operationEE11do_completeEPvPS5_RKNS_6system10error_codeEm(ptr noundef %0, ptr noundef %1, ptr noundef nonnull align 8 dereferenceable(24) %2, i64 noundef %3) #10 comdat align 2 personality ptr @__gxx_personality_v0 {
   %5 = alloca %"class.std::allocator.25", align 1
   %6 = alloca %"struct.boost::asio::detail::executor_op<boost::asio::detail::executor_function, std::allocator<void>>::ptr", align 8
-  %7 = icmp ne ptr %1, null
-  tail call void @llvm.assume(i1 %7)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %5)
   call void @llvm.lifetime.start.p0(ptr nonnull %6)
   store ptr %5, ptr %6, align 8, !tbaa !273
@@ -11800,29 +11796,29 @@ _ZN5boost4asio6detail14thread_context24top_of_thread_call_stackEv.exit.i.i: ; pr
   br i1 %.not3.i, label %.thread.i.i.i, label %.preheader.i.i.i
 
 16:                                               ; preds = %.preheader.i.i.i
-  br i1 %17, label %.preheader.i.i.i, label %.thread.i.i.i, !llvm.loop !277
-
-.preheader.i.i.i:                                 ; preds = %_ZN5boost4asio6detail14thread_context24top_of_thread_call_stackEv.exit.i.i, %16
-  %17 = phi i1 [ false, %16 ], [ true, %_ZN5boost4asio6detail14thread_context24top_of_thread_call_stackEv.exit.i.i ]
-  %indvars.iv.i.i.i = phi i64 [ 1, %16 ], [ 0, %_ZN5boost4asio6detail14thread_context24top_of_thread_call_stackEv.exit.i.i ]
-  %18 = getelementptr inbounds nuw ptr, ptr %15, i64 %indvars.iv.i.i.i
-  %19 = load ptr, ptr %18, align 8, !tbaa !4
-  %20 = icmp eq ptr %19, null
-  br i1 %20, label %21, label %16
-
-21:                                               ; preds = %.preheader.i.i.i
-  %22 = getelementptr inbounds nuw ptr, ptr %15, i64 %indvars.iv.i.i.i
-  %23 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %24 = load i8, ptr %23, align 1, !tbaa !14
-  store i8 %24, ptr %1, align 1, !tbaa !14
-  store ptr %1, ptr %22, align 8, !tbaa !4
+  br i1 %16, label %.preheader.i.i.i, label %.thread.i.i.i, !llvm.loop !277
+
+.preheader.i.i.i:                                 ; preds = %_ZN5boost4asio6detail14thread_context24top_of_thread_call_stackEv.exit.i.i, %15
+  %16 = phi i1 [ false, %15 ], [ true, %_ZN5boost4asio6detail14thread_context24top_of_thread_call_stackEv.exit.i.i ]
+  %indvars.iv.i.i.i = phi i64 [ 1, %15 ], [ 0, %_ZN5boost4asio6detail14thread_context24top_of_thread_call_stackEv.exit.i.i ]
+  %17 = getelementptr inbounds nuw ptr, ptr %14, i64 %indvars.iv.i.i.i
+  %18 = load ptr, ptr %17, align 8, !tbaa !4
+  %19 = icmp eq ptr %18, null
+  br i1 %19, label %20, label %15
+
+.preheader.i.i.i:                                 ; preds = %.preheader.i.i.i
+  %21 = getelementptr inbounds nuw ptr, ptr %14, i64 %indvars.iv.i.i.i
+  %22 = getelementptr inbounds nuw i8, ptr %1, i64 40
+  %23 = load i8, ptr %22, align 1, !tbaa !14
+  store i8 %23, ptr %1, align 1, !tbaa !14
+  store ptr %1, ptr %21, align 8, !tbaa !4
   br label %_ZN5boost4asio6detail11executor_opINS1_17executor_functionESaIvENS1_19scheduler_operationEE3ptr5resetEv.exit
 
 .thread.i.i.i:                                    ; preds = %16, %_ZN5boost4asio6detail14thread_context24top_of_thread_call_stackEv.exit.i.i, %4
   call void @free(ptr noundef %1) #38
   br label %_ZN5boost4asio6detail11executor_opINS1_17executor_functionESaIvENS1_19scheduler_operationEE3ptr5resetEv.exit
 
-_ZN5boost4asio6detail11executor_opINS1_17executor_functionESaIvENS1_19scheduler_operationEE3ptr5resetEv.exit: ; preds = %21, %.thread.i.i.i
+_ZN5boost4asio6detail11executor_opINS1_17executor_functionESaIvENS1_19scheduler_operationEE3ptr5resetEv.exit: ; preds = %20, %.thread.i.i.i
   store ptr null, ptr %8, align 8, !tbaa !275
   %.not = icmp eq ptr %0, null
   %.not.i10 = icmp eq ptr %11, null
@@ -11833,7 +11829,7 @@ _ZN5boost4asio6detail11executor_opINS1_17executor_functionESaIvENS1_19scheduler_
 
 26:                                               ; preds = %25
   %27 = load ptr, ptr %11, align 8, !tbaa !271
-  invoke void %27(ptr noundef nonnull %11, i1 noundef zeroext true)
+  invoke void %26(ptr noundef nonnull %11, i1 noundef zeroext true)
           to label %.thread unwind label %_ZN5boost4asio6detail17executor_functionD2Ev.exit13
 
 .thread:                                          ; preds = %26, %25
@@ -11854,7 +11850,7 @@ _ZN5boost4asio6detail17executor_functionD2Ev.exit13: ; preds = %26
 
 30:                                               ; preds = %29
   %31 = load ptr, ptr %11, align 8, !tbaa !271
-  invoke void %31(ptr noundef nonnull %11, i1 noundef zeroext false)
+  invoke void %30(ptr noundef nonnull %11, i1 noundef zeroext false)
           to label %_ZN5boost4asio6detail11executor_opINS1_17executor_functionESaIvENS1_19scheduler_operationEE3ptrD2Ev.exit unwind label %32
 
 32:                                               ; preds = %30
@@ -13098,14 +13094,12 @@ _ZNKSt9type_infoeqERKS_.exit.i8:                  ; preds = %_ZNK5boost4asio9exe
 
 _ZNK5boost4asio9execution6detail17any_executor_base6targetINS0_10io_context19basic_executor_typeISaIvELm4EEEEEPKT_v.exit12: ; preds = %_ZNKSt9type_infoeqERKS_.exit.thread.i11, %_ZNKSt9type_infoeqERKS_.exit.i8
   %32 = phi ptr [ %28, %_ZNKSt9type_infoeqERKS_.exit.thread.i11 ], [ %spec.select.i10, %_ZNKSt9type_infoeqERKS_.exit.i8 ]
-  %33 = icmp ne ptr %19, null
-  tail call void @llvm.assume(i1 %33)
-  %34 = icmp ne ptr %32, null
-  tail call void @llvm.assume(i1 %34)
-  %35 = load i64, ptr %19, align 8, !tbaa !337
-  %36 = load i64, ptr %32, align 8, !tbaa !337
-  %37 = icmp eq i64 %35, %36
-  ret i1 %37
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %19) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %33) ]
+  %34 = load i64, ptr %19, align 8, !tbaa !337
+  %34 = load i64, ptr %32, align 8, !tbaa !337
+  %35 = icmp eq i64 %34, %34
+  ret i1 %35
 }
 
 ; Function Attrs: mustprogress uwtable
@@ -13134,8 +13128,7 @@ _ZNKSt9type_infoeqERKS_.exit.i:                   ; preds = %2
 
 _ZNK5boost4asio9execution6detail17any_executor_base6targetINS0_10io_context19basic_executor_typeISaIvELm4EEEEEPKT_v.exit: ; preds = %_ZNKSt9type_infoeqERKS_.exit.thread.i, %_ZNKSt9type_infoeqERKS_.exit.i
   %15 = phi ptr [ %11, %_ZNKSt9type_infoeqERKS_.exit.thread.i ], [ %spec.select.i, %_ZNKSt9type_infoeqERKS_.exit.i ]
-  %16 = icmp ne ptr %15, null
-  tail call void @llvm.assume(i1 %16)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %15) ]
   tail call void @_ZNK5boost4asio10io_context19basic_executor_typeISaIvELm4EE7executeINS0_6detail17executor_functionEEEvOT_(ptr noundef nonnull align 8 dereferenceable(8) %15, ptr noundef nonnull align 8 dereferenceable(8) %1)
   ret void
 }
diff --git a/bench/c3c/optimized/sema_expr.ll b/bench/c3c/optimized/sema_expr.ll
index 126de2caaa5..556494ca695 100644
--- a/bench/c3c/optimized/sema_expr.ll
+++ b/bench/c3c/optimized/sema_expr.ll
@@ -15945,8 +15945,7 @@ type_flatten.exit:                                ; preds = %511
   br label %sema_expr_analyse_or_error.exit
 
 .critedge5.i.thread100:                           ; preds = %536, %528, %529, %.critedge5.i.thread, %.critedge5.i
-  %.not183.i = icmp ne ptr %495, null
-  tail call void @llvm.assume(i1 %.not183.i)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %495) ]
   %606 = load i32, ptr %495, align 8
   %607 = icmp eq i32 %606, 40
   br i1 %607, label %608, label %611
@@ -15960,8 +15959,7 @@ type_flatten.exit:                                ; preds = %511
   %.0156.i = phi ptr [ %610, %608 ], [ %495, %.critedge5.i.thread100 ]
   %612 = getelementptr inbounds nuw i8, ptr %.0156.i, i64 8
   %613 = load ptr, ptr %612, align 8
-  %.not184.i = icmp ne ptr %510, null
-  tail call void @llvm.assume(i1 %.not184.i)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %510) ]
   %614 = load i32, ptr %510, align 8
   %615 = icmp eq i32 %614, 40
   br i1 %615, label %616, label %619
diff --git a/bench/clap-rs/optimized/2n53bxup1mqegzwp.ll b/bench/clap-rs/optimized/2n53bxup1mqegzwp.ll
index 93eb9af69b0..60a89e3f060 100644
--- a/bench/clap-rs/optimized/2n53bxup1mqegzwp.ll
+++ b/bench/clap-rs/optimized/2n53bxup1mqegzwp.ll
@@ -67,13 +67,13 @@ define noundef zeroext i1 @"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_le
   br i1 %.not.i.i.i.i.i, label %.critedge38.backedge.i.i, label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find28_$u7b$$u7b$closure$u7d$$u7d$17hd04b32ae75c7a565E.exit.i.i.i"
 
 11:                                               ; preds = %.lr.ph.i.i
-  %12 = add nuw i64 %1, 1
-  tail call void @_ZN4core5slice5index26slice_start_index_len_fail17h0187bf4d120fc375E(i64 noundef %12, i64 noundef %1, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.9acd36be39784948a154da50af79fd9d.2) #7, !noalias !9
+  tail call void @_ZN4core5slice5index26slice_start_index_len_fail17h0187bf4d120fc375E(i64 noundef %6, i64 noundef %1, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.9acd36be39784948a154da50af79fd9d.2) #8, !noalias !9
   unreachable
 
 "_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find28_$u7b$$u7b$closure$u7d$$u7d$17hd04b32ae75c7a565E.exit.i.i.i": ; preds = %9
   %13 = getelementptr inbounds i8, ptr %0, i64 %6
-  %bcmp.i.i.i.i.i.i = tail call i32 @bcmp(ptr nonnull readonly align 1 %2, ptr nonnull readonly align 1 %13, i64 %3), !alias.scope !17, !noalias !24
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %13) ]
+  %bcmp.i.i.i.i.i.i = tail call i32 @bcmp(ptr nonnull readonly align 1 %2, ptr nonnull readonly align 1 %12, i64 %3), !alias.scope !17, !noalias !24
   %bcmp.i.i.i.fr.i.i.i = freeze i32 %bcmp.i.i.i.i.i.i
   %.not46.i.i = icmp eq i32 %bcmp.i.i.i.fr.i.i.i, 0
   br i1 %.not46.i.i, label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find17h7c8b5932dcb2a7d0E.exit", label %.critedge38.backedge.i.i
@@ -84,7 +84,8 @@ define noundef zeroext i1 @"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_le
 
 "_ZN4core4iter6traits8iterator8Iterator4find5check28_$u7b$$u7b$closure$u7d$$u7d$17hc5cf0d6b5803a3bbE.exit32.i.i": ; preds = %.critedge38.backedge.i.i, %.critedge38.preheader.i.i
   %14 = getelementptr inbounds i8, ptr %0, i64 %5
-  %bcmp.i.i.i.i29.i.i = tail call i32 @bcmp(ptr nonnull readonly align 1 %2, ptr nonnull readonly align 1 %14, i64 %3), !alias.scope !25, !noalias !32
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %13) ]
+  %bcmp.i.i.i.i29.i.i = tail call i32 @bcmp(ptr nonnull readonly align 1 %2, ptr nonnull readonly align 1 %13, i64 %3), !alias.scope !25, !noalias !32
   %bcmp.i.i.i.fr.i30.i.i = freeze i32 %bcmp.i.i.i.i29.i.i
   %.not37.i.i = icmp eq i32 %bcmp.i.i.i.fr.i30.i.i, 0
   br label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find17h7c8b5932dcb2a7d0E.exit"
@@ -116,11 +117,12 @@ define { i64, i64 } @"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext
   br i1 %.not.i.i.i.i, label %.critedge38.backedge.i, label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find28_$u7b$$u7b$closure$u7d$$u7d$17hd04b32ae75c7a565E.exit.i.i"
 
 11:                                               ; preds = %.lr.ph.i
-  tail call void @_ZN4core5slice5index26slice_start_index_len_fail17h0187bf4d120fc375E(i64 noundef %6, i64 noundef %1, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.9acd36be39784948a154da50af79fd9d.2) #7, !noalias !37
+  tail call void @_ZN4core5slice5index26slice_start_index_len_fail17h0187bf4d120fc375E(i64 noundef %6, i64 noundef %1, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.9acd36be39784948a154da50af79fd9d.2) #8, !noalias !37
   unreachable
 
 "_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find28_$u7b$$u7b$closure$u7d$$u7d$17hd04b32ae75c7a565E.exit.i.i": ; preds = %9
   %12 = getelementptr inbounds i8, ptr %0, i64 %6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %12) ]
   %bcmp.i.i.i.i.i = tail call i32 @bcmp(ptr nonnull readonly align 1 %2, ptr nonnull readonly align 1 %12, i64 %3), !alias.scope !45, !noalias !37
   %bcmp.i.i.i.fr.i.i = freeze i32 %bcmp.i.i.i.i.i
   %.not46.i = icmp eq i32 %bcmp.i.i.i.fr.i.i, 0
@@ -132,6 +134,7 @@ define { i64, i64 } @"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext
 
 "_ZN4core4iter6traits8iterator8Iterator4find5check28_$u7b$$u7b$closure$u7d$$u7d$17hc5cf0d6b5803a3bbE.exit32.i": ; preds = %.critedge38.backedge.i, %.critedge38.preheader.i
   %13 = getelementptr inbounds i8, ptr %0, i64 %5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %13) ]
   %bcmp.i.i.i.i29.i = tail call i32 @bcmp(ptr nonnull readonly align 1 %2, ptr nonnull readonly align 1 %13, i64 %3), !alias.scope !52, !noalias !59
   %bcmp.i.i.i.fr.i30.i = freeze i32 %bcmp.i.i.i.i29.i
   %.not37.i = icmp eq i32 %bcmp.i.i.i.fr.i30.i, 0
@@ -146,12 +149,13 @@ define { i64, i64 } @"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext
   ret { i64, i64 } %15
 }
 
-; Function Attrs: mustprogress nofree norecurse nounwind nonlazybind willreturn memory(argmem: read) uwtable
+; Function Attrs: mustprogress nofree norecurse nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: write) uwtable
 define { ptr, i64 } @"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$12strip_prefix17hc501523431ab0863E"(ptr noalias noundef nonnull readonly align 1 %0, i64 noundef %1, ptr noalias noundef nonnull readonly align 1 captures(none) %2, i64 noundef %3) unnamed_addr #2 {
   %.not.i = icmp ugt i64 %3, %1
   br i1 %.not.i, label %"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$12strip_prefix17hac515435bac00690E.exit", label %5
 
 5:                                                ; preds = %4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   %bcmp.i.i = tail call i32 @bcmp(ptr nonnull readonly align 1 %0, ptr nonnull readonly align 1 %2, i64 %3), !alias.scope !64
   %6 = icmp eq i32 %bcmp.i.i, 0
   br i1 %6, label %7, label %"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$12strip_prefix17hac515435bac00690E.exit"
@@ -169,12 +173,13 @@ define { ptr, i64 } @"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext
   ret { ptr, i64 } %11
 }
 
-; Function Attrs: mustprogress nofree norecurse nounwind nonlazybind willreturn memory(argmem: read) uwtable
+; Function Attrs: mustprogress nofree norecurse nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: write) uwtable
 define noundef zeroext i1 @"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE"(ptr noalias noundef nonnull readonly align 1 captures(none) %0, i64 noundef %1, ptr noalias noundef nonnull readonly align 1 captures(none) %2, i64 noundef %3) unnamed_addr #2 {
   %.not.i = icmp ult i64 %1, %3
   br i1 %.not.i, label %"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$11starts_with17hd16f7bb69e6397e5E.exit", label %"_ZN73_$LT$$u5b$A$u5d$$u20$as$u20$core..slice..cmp..SlicePartialEq$LT$B$GT$$GT$5equal17ha932f9614aebdad1E.exit.i"
 
 "_ZN73_$LT$$u5b$A$u5d$$u20$as$u20$core..slice..cmp..SlicePartialEq$LT$B$GT$$GT$5equal17ha932f9614aebdad1E.exit.i": ; preds = %4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   %bcmp.i.i = tail call i32 @bcmp(ptr nonnull readonly align 1 %2, ptr nonnull readonly align 1 %0, i64 %3), !alias.scope !71
   %5 = icmp eq i32 %bcmp.i.i, 0
   br label %"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$11starts_with17hd16f7bb69e6397e5E.exit"
@@ -235,13 +240,13 @@ define void @"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrE
   br i1 %.not.i.i.i.i.i, label %.critedge38.backedge.i.i, label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find28_$u7b$$u7b$closure$u7d$$u7d$17hd04b32ae75c7a565E.exit.i.i.i"
 
 12:                                               ; preds = %.lr.ph.i.i
-  %13 = add nuw i64 %2, 1
-  tail call void @_ZN4core5slice5index26slice_start_index_len_fail17h0187bf4d120fc375E(i64 noundef %13, i64 noundef %2, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.9acd36be39784948a154da50af79fd9d.2) #7, !noalias !83
+  tail call void @_ZN4core5slice5index26slice_start_index_len_fail17h0187bf4d120fc375E(i64 noundef %7, i64 noundef %2, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.9acd36be39784948a154da50af79fd9d.2) #8, !noalias !83
   unreachable
 
 "_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find28_$u7b$$u7b$closure$u7d$$u7d$17hd04b32ae75c7a565E.exit.i.i.i": ; preds = %10
   %14 = getelementptr inbounds i8, ptr %1, i64 %7
-  %bcmp.i.i.i.i.i.i = tail call i32 @bcmp(ptr nonnull readonly align 1 %3, ptr nonnull readonly align 1 %14, i64 %4), !alias.scope !91, !noalias !98
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %14) ]
+  %bcmp.i.i.i.i.i.i = tail call i32 @bcmp(ptr nonnull readonly align 1 %3, ptr nonnull readonly align 1 %13, i64 %4), !alias.scope !91, !noalias !98
   %bcmp.i.i.i.fr.i.i.i = freeze i32 %bcmp.i.i.i.i.i.i
   %.not46.i.i = icmp eq i32 %bcmp.i.i.i.fr.i.i.i, 0
   br i1 %.not46.i.i, label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find17h7c8b5932dcb2a7d0E.exit.thread16", label %.critedge38.backedge.i.i
@@ -252,7 +257,8 @@ define void @"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrE
 
 "_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find17h7c8b5932dcb2a7d0E.exit": ; preds = %.critedge38.backedge.i.i, %.critedge38.preheader.i.i
   %15 = getelementptr inbounds i8, ptr %1, i64 %6
-  %bcmp.i.i.i.i29.i.i = tail call i32 @bcmp(ptr nonnull readonly align 1 %3, ptr nonnull readonly align 1 %15, i64 %4), !alias.scope !99, !noalias !106
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %14) ]
+  %bcmp.i.i.i.i29.i.i = tail call i32 @bcmp(ptr nonnull readonly align 1 %3, ptr nonnull readonly align 1 %14, i64 %4), !alias.scope !99, !noalias !106
   %bcmp.i.i.i.fr.i30.i.i = freeze i32 %bcmp.i.i.i.i29.i.i
   %.not37.i.i.not = icmp eq i32 %bcmp.i.i.i.fr.i30.i.i, 0
   br i1 %.not37.i.i.not, label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find17h7c8b5932dcb2a7d0E.exit.thread16", label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find17h7c8b5932dcb2a7d0E.exit.thread"
@@ -264,7 +270,7 @@ define void @"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrE
   br i1 %17, label %18, label %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h2e16e49de880e58eE.llvm.8584779980762939608.exit"
 
 18:                                               ; preds = %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find17h7c8b5932dcb2a7d0E.exit.thread16"
-  tail call void @_ZN4core5slice5index24slice_end_index_len_fail17h9163fa4abd3ca1acE(i64 noundef %.sroa.4.0.i19, i64 noundef %2, ptr noalias noundef nonnull readonly align 8 dereferenceable(24) @anon.9acd36be39784948a154da50af79fd9d.6.llvm.8584779980762939608) #7, !noalias !111
+  tail call void @_ZN4core5slice5index24slice_end_index_len_fail17h9163fa4abd3ca1acE(i64 noundef %.sroa.4.0.i19, i64 noundef %2, ptr noalias noundef nonnull readonly align 8 dereferenceable(24) @anon.9acd36be39784948a154da50af79fd9d.6.llvm.8584779980762939608) #8, !noalias !111
   unreachable
 
 "_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h2e16e49de880e58eE.llvm.8584779980762939608.exit": ; preds = %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$4find17h7c8b5932dcb2a7d0E.exit.thread16"
@@ -316,6 +322,9 @@ declare hidden void @_ZN4core9panicking13assert_failed17h78db69186c9d5469E(i8 no
 ; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite)
 declare void @llvm.lifetime.start.p0(ptr captures(none)) #4
 
+; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #5
+
 ; Function Attrs: nocallback nofree nounwind nonlazybind willreturn memory(argmem: read)
 declare i32 @bcmp(ptr captures(none), ptr captures(none), i64) local_unnamed_addr #5
 
@@ -324,12 +333,13 @@ declare void @llvm.experimental.noalias.scope.decl(metadata) #6
 
 attributes #0 = { inlinehint nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #1 = { nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #2 = { mustprogress nofree norecurse nounwind nonlazybind willreturn memory(argmem: read) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #2 = { mustprogress nofree norecurse nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: write) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #3 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #4 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
-attributes #5 = { nocallback nofree nounwind nonlazybind willreturn memory(argmem: read) }
-attributes #6 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
-attributes #7 = { noreturn }
+attributes #5 = { nocallback nofree nounwind nonlazybind willreturn memory(argmem: write) }
+attributes #6 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: read) }
+attributes #7 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #8 = { noreturn }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/clap-rs/optimized/4r6y4qxwk52m92uh.ll b/bench/clap-rs/optimized/4r6y4qxwk52m92uh.ll
index ed28694df85..8fcead03839 100644
--- a/bench/clap-rs/optimized/4r6y4qxwk52m92uh.ll
+++ b/bench/clap-rs/optimized/4r6y4qxwk52m92uh.ll
@@ -217,18 +217,19 @@ define { ptr, i64 } @_ZN8clap_lex7RawArgs7peek_os17he56275292fcdee6aE(ptr noalia
 ; Function Attrs: nonlazybind uwtable
 define { ptr, ptr } @_ZN8clap_lex7RawArgs9remaining17h51b7b126f9c1f904E(ptr noalias noundef readonly align 8 captures(none) dereferenceable(24) %0, ptr noalias noundef align 8 captures(none) dereferenceable(8) %1) unnamed_addr #2 personality ptr @rust_eh_personality {
   %3 = load i64, ptr %1, align 8, !noundef !4
-  %4 = getelementptr inbounds nuw i8, ptr %0, i64 16
-  %.val2 = load i64, ptr %4, align 8, !noundef !4
-  %5 = icmp ugt i64 %3, %.val2
-  br i1 %5, label %6, label %"_ZN81_$LT$alloc..vec..Vec$LT$T$C$A$GT$$u20$as$u20$core..ops..index..Index$LT$I$GT$$GT$5index17hfb34af44b3b02965E.exit"
+  %4 = getelementptr inbounds nuw i8, ptr %0, i64 8
+  %.val2 = load ptr, ptr %4, align 8, !nonnull !4, !noundef !4
+  %5 = getelementptr inbounds nuw i8, ptr %0, i64 16
+  %.val2 = load i64, ptr %5, align 8, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  %6 = icmp ugt i64 %3, %.val2
+  br i1 %6, label %7, label %"_ZN81_$LT$alloc..vec..Vec$LT$T$C$A$GT$$u20$as$u20$core..ops..index..Index$LT$I$GT$$GT$5index17hfb34af44b3b02965E.exit"
 
 6:                                                ; preds = %2
-  tail call void @_ZN4core5slice5index26slice_start_index_len_fail17h0187bf4d120fc375E(i64 noundef %3, i64 noundef %.val2, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.248846a2e22cbdbe35d199858cf2b949.23) #23, !noalias !22
+  tail call void @_ZN4core5slice5index26slice_start_index_len_fail17h0187bf4d120fc375E(i64 noundef %3, i64 noundef %.val2, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.248846a2e22cbdbe35d199858cf2b949.23) #24, !noalias !22
   unreachable
 
 "_ZN81_$LT$alloc..vec..Vec$LT$T$C$A$GT$$u20$as$u20$core..ops..index..Index$LT$I$GT$$GT$5index17hfb34af44b3b02965E.exit": ; preds = %2
-  %7 = getelementptr inbounds nuw i8, ptr %0, i64 8
-  %.val = load ptr, ptr %7, align 8, !nonnull !4, !noundef !4
   %8 = getelementptr inbounds { { { { i64, ptr }, i64 } } }, ptr %.val, i64 %3
   %9 = getelementptr inbounds { { { { i64, ptr }, i64 } } }, ptr %.val, i64 %.val2
   store i64 %.val2, ptr %1, align 8
@@ -351,6 +352,7 @@ define noundef zeroext i1 @_ZN8clap_lex9ParsedArg18is_negative_number17he6231e86
   br i1 %or.cond, label %"_ZN8clap_lex9ParsedArg18is_negative_number28_$u7b$$u7b$closure$u7d$$u7d$17h413729e608f85e83E.exit", label %"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$11starts_with17hd16f7bb69e6397e5E.exit.i.i"
 
 "_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$11starts_with17hd16f7bb69e6397e5E.exit.i.i": ; preds = %1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   %rhsc.i = load i8, ptr %8, align 1, !alias.scope !43
   %rhsc.fr.i = freeze i8 %rhsc.i
   %11 = icmp eq i8 %rhsc.fr.i, 45
@@ -460,7 +462,7 @@ define void @_ZN8clap_lex9ParsedArg7to_long17hdc1aac1c7ed190f0E(ptr noalias noun
   br i1 %18, label %19, label %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h2e16e49de880e58eE.llvm.8584779980762939608.exit.i"
 
 19:                                               ; preds = %16
-  tail call void @_ZN4core5slice5index24slice_end_index_len_fail17h9163fa4abd3ca1acE(i64 noundef %.fca.1.extract.i20, i64 noundef %.fca.1.extract.i, ptr noalias noundef nonnull readonly align 8 dereferenceable(24) @anon.9acd36be39784948a154da50af79fd9d.6.llvm.8584779980762939608) #23, !noalias !52
+  tail call void @_ZN4core5slice5index24slice_end_index_len_fail17h9163fa4abd3ca1acE(i64 noundef %.fca.1.extract.i20, i64 noundef %.fca.1.extract.i, ptr noalias noundef nonnull readonly align 8 dereferenceable(24) @anon.9acd36be39784948a154da50af79fd9d.6.llvm.8584779980762939608) #24, !noalias !52
   unreachable
 
 "_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h2e16e49de880e58eE.llvm.8584779980762939608.exit.i": ; preds = %16
@@ -468,7 +470,7 @@ define void @_ZN8clap_lex9ParsedArg7to_long17hdc1aac1c7ed190f0E(ptr noalias noun
   br i1 %20, label %21, label %23
 
 21:                                               ; preds = %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h2e16e49de880e58eE.llvm.8584779980762939608.exit.i"
-  tail call void @_ZN4core5slice5index26slice_start_index_len_fail17h0187bf4d120fc375E(i64 noundef %17, i64 noundef %.fca.1.extract.i, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.9acd36be39784948a154da50af79fd9d.7.llvm.8584779980762939608) #23, !noalias !49
+  tail call void @_ZN4core5slice5index26slice_start_index_len_fail17h0187bf4d120fc375E(i64 noundef %17, i64 noundef %.fca.1.extract.i, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.9acd36be39784948a154da50af79fd9d.7.llvm.8584779980762939608) #24, !noalias !49
   unreachable
 
 22:                                               ; preds = %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$10split_once17h509237bc95af7a93E.exit.thread", %12, %11
@@ -506,8 +508,8 @@ define void @_ZN8clap_lex9ParsedArg7to_long17hdc1aac1c7ed190f0E(ptr noalias noun
   br label %22
 }
 
-; Function Attrs: mustprogress nofree norecurse nounwind nonlazybind willreturn memory(read, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable
-define noundef zeroext i1 @_ZN8clap_lex9ParsedArg7is_long17h0d06ccc45c5ff929E(ptr noalias noundef readonly align 8 captures(none) dereferenceable(16) %0) unnamed_addr #11 {
+; Function Attrs: mustprogress nofree norecurse nounwind nonlazybind willreturn memory(read, inaccessiblemem: write, target_mem0: none, target_mem1: none) uwtable
+define noundef zeroext i1 @_ZN8clap_lex9ParsedArg7is_long17h0d06ccc45c5ff929E(ptr noalias noundef readonly align 8 captures(none) dereferenceable(16) %0) unnamed_addr #12 {
   %2 = load ptr, ptr %0, align 8, !nonnull !4, !align !31, !noundef !4
   %3 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %4 = load i64, ptr %3, align 8, !noundef !4
@@ -515,6 +517,7 @@ define noundef zeroext i1 @_ZN8clap_lex9ParsedArg7is_long17h0d06ccc45c5ff929E(pt
   br i1 %.not.i.i, label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE.exit.thread", label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE.exit"
 
 "_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE.exit": ; preds = %1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   %bcmp.i.i.i = tail call i32 @bcmp(ptr noundef nonnull readonly align 1 dereferenceable(2) @anon.248846a2e22cbdbe35d199858cf2b949.26, ptr noundef nonnull readonly align 1 dereferenceable(2) %2, i64 2), !alias.scope !55
   %5 = icmp eq i32 %bcmp.i.i.i, 0
   br i1 %5, label %6, label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE.exit.thread"
@@ -552,6 +555,7 @@ define void @_ZN8clap_lex9ParsedArg8to_short17h5708d56a9045f7a7E(ptr noalias nou
   br i1 %.not.i.i, label %15, label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE.exit"
 
 "_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE.exit": ; preds = %11
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.fca.0.extract.i) ]
   %rhsc = load i8, ptr %.fca.0.extract.i, align 1
   %12 = icmp eq i8 %rhsc, 45
   br i1 %12, label %14, label %16
@@ -588,7 +592,7 @@ define void @_ZN8clap_lex9ParsedArg8to_short17h5708d56a9045f7a7E(ptr noalias nou
   br i1 %.not.i.i.i, label %24, label %_ZN8clap_lex3ext8split_at17hf432e678d412a774E.exit.i.i
 
 24:                                               ; preds = %23
-  tail call void @_ZN4core9panicking5panic17hb837a5ebbbe5b188E(ptr noalias noundef nonnull readonly align 1 @anon.fc1c78a371a506ea9d587e654a45c3a3.1.llvm.9337090908805262772, i64 noundef 35, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.fc1c78a371a506ea9d587e654a45c3a3.3.llvm.9337090908805262772) #23, !noalias !80
+  tail call void @_ZN4core9panicking5panic17hb837a5ebbbe5b188E(ptr noalias noundef nonnull readonly align 1 @anon.fc1c78a371a506ea9d587e654a45c3a3.1.llvm.9337090908805262772, i64 noundef 35, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.fc1c78a371a506ea9d587e654a45c3a3.3.llvm.9337090908805262772) #24, !noalias !80
   unreachable
 
 _ZN8clap_lex3ext8split_at17hf432e678d412a774E.exit.i.i: ; preds = %23
@@ -603,7 +607,7 @@ _ZN8clap_lex3ext8split_at17hf432e678d412a774E.exit.i.i: ; preds = %23
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !87
   %27 = getelementptr inbounds nuw i8, ptr %4, i64 8
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(16) %3, ptr noundef nonnull readonly align 8 dereferenceable(16) %27, i64 16, i1 false), !noalias !72
-  call void @_ZN4core6result13unwrap_failed17h03d8a5018196e1cdE(ptr noalias noundef nonnull readonly align 1 @anon.248846a2e22cbdbe35d199858cf2b949.15, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.248846a2e22cbdbe35d199858cf2b949.16, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.248846a2e22cbdbe35d199858cf2b949.30) #23, !noalias !88
+  call void @_ZN4core6result13unwrap_failed17h03d8a5018196e1cdE(ptr noalias noundef nonnull readonly align 1 @anon.248846a2e22cbdbe35d199858cf2b949.15, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.248846a2e22cbdbe35d199858cf2b949.16, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.248846a2e22cbdbe35d199858cf2b949.30) #24, !noalias !88
   unreachable
 
 "_ZN4core6result19Result$LT$T$C$E$GT$6unwrap17he9d986bffa271cbbE.exit.i.i": ; preds = %_ZN8clap_lex3ext8split_at17hf432e678d412a774E.exit.i.i
@@ -642,8 +646,8 @@ _ZN8clap_lex10ShortFlags3new17hc050306f15f417c3E.exit: ; preds = %19, %"_ZN4core
   ret void
 }
 
-; Function Attrs: mustprogress nofree norecurse nounwind nonlazybind willreturn memory(read, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable
-define noundef zeroext i1 @_ZN8clap_lex9ParsedArg8is_short17h4f124932d060574aE(ptr noalias noundef readonly align 8 captures(none) dereferenceable(16) %0) unnamed_addr #11 {
+; Function Attrs: mustprogress nofree norecurse nounwind nonlazybind willreturn memory(read, inaccessiblemem: write, target_mem0: none, target_mem1: none) uwtable
+define noundef zeroext i1 @_ZN8clap_lex9ParsedArg8is_short17h4f124932d060574aE(ptr noalias noundef readonly align 8 captures(none) dereferenceable(16) %0) unnamed_addr #12 {
   %2 = load ptr, ptr %0, align 8, !nonnull !4, !align !31, !noundef !4
   %3 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %4 = load i64, ptr %3, align 8, !noundef !4
@@ -651,6 +655,7 @@ define noundef zeroext i1 @_ZN8clap_lex9ParsedArg8is_short17h4f124932d060574aE(p
   br i1 %.not.i.i, label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE.exit.thread", label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE.exit"
 
 "_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE.exit": ; preds = %1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   %rhsc = load i8, ptr %2, align 1
   %5 = icmp ne i8 %rhsc, 45
   %.not.i.i1 = icmp eq i64 %4, 1
@@ -658,6 +663,7 @@ define noundef zeroext i1 @_ZN8clap_lex9ParsedArg8is_short17h4f124932d060574aE(p
   br i1 %or.cond, label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE.exit.thread", label %"_ZN73_$LT$$u5b$A$u5d$$u20$as$u20$core..slice..cmp..SlicePartialEq$LT$B$GT$$GT$5equal17ha932f9614aebdad1E.exit.i.i4"
 
 "_ZN73_$LT$$u5b$A$u5d$$u20$as$u20$core..slice..cmp..SlicePartialEq$LT$B$GT$$GT$5equal17ha932f9614aebdad1E.exit.i.i4": ; preds = %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE.exit"
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   %bcmp.i.i.i5 = tail call i32 @bcmp(ptr noundef nonnull readonly align 1 dereferenceable(2) @anon.248846a2e22cbdbe35d199858cf2b949.26, ptr noundef nonnull readonly align 1 dereferenceable(2) %2, i64 2), !alias.scope !89
   %6 = icmp ne i32 %bcmp.i.i.i5, 0
   br label %"_ZN67_$LT$std..ffi..os_str..OsStr$u20$as$u20$clap_lex..ext..OsStrExt$GT$11starts_with17h4baa0d2223d7544fE.exit.thread"
@@ -712,7 +718,7 @@ define void @_ZN8clap_lex9ParsedArg7display17h9976f60a07ce43b9E(ptr noalias noun
 }
 
 ; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: readwrite, target_mem0: none, target_mem1: none) uwtable
-define { i64, i64 } @_ZN8clap_lex10ShortFlags10advance_by17hd7b5dc76a7f69860E(ptr noalias noundef align 8 captures(none) dereferenceable(56) %0, i64 noundef %1) unnamed_addr #12 {
+define { i64, i64 } @_ZN8clap_lex10ShortFlags10advance_by17hd7b5dc76a7f69860E(ptr noalias noundef align 8 captures(none) dereferenceable(56) %0, i64 noundef %1) unnamed_addr #13 {
   %.not = icmp eq i64 %1, 0
   br i1 %.not, label %.thread, label %.lr.ph
 
@@ -751,6 +757,7 @@ define { i64, i64 } @_ZN8clap_lex10ShortFlags10advance_by17hd7b5dc76a7f69860E(pt
   tail call void @llvm.assume(i1 %18)
   %19 = getelementptr inbounds nuw i8, ptr %9, i64 2
   store ptr %19, ptr %3, align 8, !alias.scope !122, !noalias !108
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %14) ]
   %20 = icmp samesign ugt i8 %15, -33
   br i1 %20, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17ha2daf1f17116cc3bE.exit15.i.i.i.i", label %.thread53
 
@@ -760,6 +767,7 @@ define { i64, i64 } @_ZN8clap_lex10ShortFlags10advance_by17hd7b5dc76a7f69860E(pt
   tail call void @llvm.assume(i1 %22)
   %23 = getelementptr inbounds nuw i8, ptr %9, i64 3
   store ptr %23, ptr %3, align 8, !alias.scope !125, !noalias !108
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %19) ]
   %24 = icmp samesign ugt i8 %15, -17
   br i1 %24, label %25, label %.thread53
 
@@ -773,6 +781,7 @@ define { i64, i64 } @_ZN8clap_lex10ShortFlags10advance_by17hd7b5dc76a7f69860E(pt
   tail call void @llvm.assume(i1 %31)
   %32 = getelementptr inbounds nuw i8, ptr %9, i64 4
   store ptr %32, ptr %3, align 8, !alias.scope !128, !noalias !108
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %23) ]
   %33 = load i8, ptr %23, align 1, !noalias !121, !noundef !4
   %34 = shl nuw nsw i32 %17, 18
   %35 = and i32 %34, 1835008
@@ -828,7 +837,7 @@ define noundef zeroext i1 @_ZN8clap_lex10ShortFlags8is_empty17h0654b78f2bbd285aE
 }
 
 ; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable
-define noundef zeroext i1 @_ZN8clap_lex10ShortFlags18is_negative_number17hfbe51699063bd852E(ptr noalias noundef readonly align 8 captures(none) dereferenceable(56) %0) unnamed_addr #13 personality ptr @rust_eh_personality {
+define noundef zeroext i1 @_ZN8clap_lex10ShortFlags18is_negative_number17hfbe51699063bd852E(ptr noalias noundef readonly align 8 captures(none) dereferenceable(56) %0) unnamed_addr #14 personality ptr @rust_eh_personality {
   %2 = getelementptr inbounds nuw i8, ptr %0, i64 40
   %3 = load ptr, ptr %2, align 8, !noundef !4
   %.not = icmp eq ptr %3, null
@@ -929,6 +938,7 @@ define void @_ZN8clap_lex10ShortFlags9next_flag17ha2bfb32424d88ce6E(ptr noalias
   tail call void @llvm.assume(i1 %15)
   %16 = getelementptr inbounds nuw i8, ptr %6, i64 2
   store ptr %16, ptr %3, align 8, !alias.scope !151
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %10) ]
   %17 = load i8, ptr %10, align 1, !noalias !150, !noundef !4
   %18 = shl nuw nsw i32 %14, 6
   %19 = and i8 %17, 63
@@ -946,6 +956,7 @@ define void @_ZN8clap_lex10ShortFlags9next_flag17ha2bfb32424d88ce6E(ptr noalias
   tail call void @llvm.assume(i1 %25)
   %26 = getelementptr inbounds nuw i8, ptr %6, i64 3
   store ptr %26, ptr %3, align 8, !alias.scope !154
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %16) ]
   %27 = load i8, ptr %16, align 1, !noalias !150, !noundef !4
   %28 = shl nuw nsw i32 %20, 6
   %29 = and i8 %27, 63
@@ -961,6 +972,7 @@ define void @_ZN8clap_lex10ShortFlags9next_flag17ha2bfb32424d88ce6E(ptr noalias
   tail call void @llvm.assume(i1 %36)
   %37 = getelementptr inbounds nuw i8, ptr %6, i64 4
   store ptr %37, ptr %3, align 8, !alias.scope !157
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %26) ]
   %38 = load i8, ptr %26, align 1, !noalias !150, !noundef !4
   %39 = shl nuw nsw i32 %14, 18
   %40 = and i32 %39, 1835008
@@ -1031,6 +1043,7 @@ define { ptr, i64 } @_ZN8clap_lex10ShortFlags13next_value_os17hb3f4ea668f9a5a12E
   %12 = icmp ne ptr %8, %4
   tail call void @llvm.assume(i1 %12)
   %13 = getelementptr inbounds nuw i8, ptr %5, i64 2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   %14 = icmp samesign ugt i8 %9, -33
   br i1 %14, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17ha2daf1f17116cc3bE.exit15.i.i", label %"_ZN87_$LT$core..str..iter..CharIndices$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17hfe4b4302862dc0f7E.exit"
 
@@ -1038,6 +1051,7 @@ define { ptr, i64 } @_ZN8clap_lex10ShortFlags13next_value_os17hb3f4ea668f9a5a12E
   %15 = load i8, ptr %8, align 1, !noalias !169, !noundef !4
   %16 = icmp ne ptr %13, %4
   tail call void @llvm.assume(i1 %16)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %13) ]
   %17 = icmp samesign ugt i8 %9, -17
   br i1 %17, label %18, label %"_ZN87_$LT$core..str..iter..CharIndices$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17hfe4b4302862dc0f7E.exit"
 
@@ -1052,6 +1066,7 @@ define { ptr, i64 } @_ZN8clap_lex10ShortFlags13next_value_os17hb3f4ea668f9a5a12E
   tail call void @llvm.assume(i1 %25)
   %26 = getelementptr inbounds nuw i8, ptr %5, i64 4
   store ptr %26, ptr %2, align 8, !alias.scope !170
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %19) ]
   %27 = load i8, ptr %19, align 1, !noalias !169, !noundef !4
   %28 = shl nuw nsw i32 %11, 18
   %29 = and i32 %28, 1835008
@@ -1077,7 +1092,7 @@ define { ptr, i64 } @_ZN8clap_lex10ShortFlags13next_value_os17hb3f4ea668f9a5a12E
   br i1 %.not.i, label %42, label %_ZN8clap_lex3ext8split_at17hf432e678d412a774E.exit
 
 42:                                               ; preds = %"_ZN87_$LT$core..str..iter..CharIndices$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17hfe4b4302862dc0f7E.exit"
-  tail call void @_ZN4core9panicking5panic17hb837a5ebbbe5b188E(ptr noalias noundef nonnull readonly align 1 @anon.fc1c78a371a506ea9d587e654a45c3a3.1.llvm.9337090908805262772, i64 noundef 35, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.fc1c78a371a506ea9d587e654a45c3a3.3.llvm.9337090908805262772) #23, !noalias !173
+  tail call void @_ZN4core9panicking5panic17hb837a5ebbbe5b188E(ptr noalias noundef nonnull readonly align 1 @anon.fc1c78a371a506ea9d587e654a45c3a3.1.llvm.9337090908805262772, i64 noundef 35, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.fc1c78a371a506ea9d587e654a45c3a3.3.llvm.9337090908805262772) #24, !noalias !173
   unreachable
 
 _ZN8clap_lex3ext8split_at17hf432e678d412a774E.exit: ; preds = %"_ZN87_$LT$core..str..iter..CharIndices$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17hfe4b4302862dc0f7E.exit"
@@ -1134,6 +1149,7 @@ define void @"_ZN79_$LT$clap_lex..ShortFlags$u20$as$u20$core..iter..traits..iter
   tail call void @llvm.assume(i1 %15)
   %16 = getelementptr inbounds nuw i8, ptr %6, i64 2
   store ptr %16, ptr %3, align 8, !alias.scope !195, !noalias !177
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %10) ]
   %17 = load i8, ptr %10, align 1, !noalias !194, !noundef !4
   %18 = shl nuw nsw i32 %14, 6
   %19 = and i8 %17, 63
@@ -1151,6 +1167,7 @@ define void @"_ZN79_$LT$clap_lex..ShortFlags$u20$as$u20$core..iter..traits..iter
   tail call void @llvm.assume(i1 %25)
   %26 = getelementptr inbounds nuw i8, ptr %6, i64 3
   store ptr %26, ptr %3, align 8, !alias.scope !198, !noalias !177
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %16) ]
   %27 = load i8, ptr %16, align 1, !noalias !194, !noundef !4
   %28 = shl nuw nsw i32 %20, 6
   %29 = and i8 %27, 63
@@ -1166,6 +1183,7 @@ define void @"_ZN79_$LT$clap_lex..ShortFlags$u20$as$u20$core..iter..traits..iter
   tail call void @llvm.assume(i1 %36)
   %37 = getelementptr inbounds nuw i8, ptr %6, i64 4
   store ptr %37, ptr %3, align 8, !alias.scope !201, !noalias !177
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %26) ]
   %38 = load i8, ptr %26, align 1, !noalias !194, !noundef !4
   %39 = shl nuw nsw i32 %14, 18
   %40 = and i32 %39, 1835008
@@ -1310,18 +1328,19 @@ attributes #8 = { mustprogress nofree norecurse nosync nounwind nonlazybind will
 attributes #9 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: read) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #10 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #11 = { mustprogress nofree norecurse nounwind nonlazybind willreturn memory(read, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #12 = { nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: readwrite, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #13 = { nofree norecurse nosync nounwind nonlazybind memory(read, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #14 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #15 = { mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
-attributes #16 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
-attributes #17 = { mustprogress nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
-attributes #18 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: write) }
-attributes #19 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
-attributes #20 = { nocallback nofree nounwind nonlazybind willreturn memory(argmem: read) }
-attributes #21 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
-attributes #22 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
-attributes #23 = { noreturn }
+attributes #12 = { nofree norecurse nosync nounwind nonlazybind memory(read, argmem: write, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #13 = { nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: readwrite, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #14 = { nofree norecurse nosync nounwind nonlazybind memory(read, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #15 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #16 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: write) }
+attributes #17 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
+attributes #18 = { mustprogress nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
+attributes #19 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: write) }
+attributes #20 = { nocallback nofree nounwind nonlazybind willreturn memory(argmem: readwrite) }
+attributes #21 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: read) }
+attributes #22 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #23 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
+attributes #24 = { noreturn }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/cmake/optimized/nghttp2_session.ll b/bench/cmake/optimized/nghttp2_session.ll
index ea85043f44c..12cebc4e196 100644
--- a/bench/cmake/optimized/nghttp2_session.ll
+++ b/bench/cmake/optimized/nghttp2_session.ll
@@ -13324,17 +13324,16 @@ define dso_local i32 @nghttp2_session_upgrade(ptr noundef %0, ptr noundef %1, i6
 
 nghttp2_session_get_stream.exit:                  ; preds = %4
   %6 = tail call ptr @nghttp2_map_find(ptr noundef %0, i32 noundef 1) #20
-  %7 = icmp ne ptr %6, null
-  tail call void @llvm.assume(i1 %7)
-  %8 = getelementptr inbounds nuw i8, ptr %6, i64 204
-  %9 = load i32, ptr %8, align 4, !tbaa !42
-  %10 = icmp eq i32 %9, 5
-  %spec.select.i = select i1 %10, ptr null, ptr %6
-  %11 = getelementptr inbounds nuw i8, ptr %spec.select.i, i64 212
-  %12 = load i32, ptr %11, align 4, !tbaa !246
-  %13 = or i32 %12, 1024
-  store i32 %13, ptr %11, align 4, !tbaa !246
-  br label %14
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
+  %7 = getelementptr inbounds nuw i8, ptr %6, i64 204
+  %8 = load i32, ptr %7, align 4, !tbaa !42
+  %9 = icmp eq i32 %8, 5
+  %spec.select.i = select i1 %9, ptr null, ptr %6
+  %10 = getelementptr inbounds nuw i8, ptr %spec.select.i, i64 212
+  %11 = load i32, ptr %10, align 4, !tbaa !246
+  %12 = or i32 %11, 1024
+  store i32 %12, ptr %10, align 4, !tbaa !246
+  br label %13
 
 14:                                               ; preds = %4, %nghttp2_session_get_stream.exit
   ret i32 %5
diff --git a/bench/cpython/optimized/_functoolsmodule.ll b/bench/cpython/optimized/_functoolsmodule.ll
index 88b5e3023c7..aa31bdaaafb 100644
--- a/bench/cpython/optimized/_functoolsmodule.ll
+++ b/bench/cpython/optimized/_functoolsmodule.ll
@@ -1870,23 +1870,22 @@ define internal ptr @placeholder_new(ptr noundef %0, ptr noundef readonly captur
 
 get_functools_state_by_type.exit:                 ; preds = %6, %5
   %10 = tail call ptr @PyType_GetModuleByDef(ptr noundef %0, ptr noundef nonnull @_functools_module) #10
-  %11 = icmp ne ptr %10, null
-  tail call void @llvm.assume(i1 %11)
-  %12 = getelementptr i8, ptr %10, i64 32
-  %.val.i = load ptr, ptr %12, align 8, !tbaa !4
-  %13 = getelementptr inbounds nuw i8, ptr %.val.i, i64 16
-  %14 = load ptr, ptr %13, align 8, !tbaa !16
-  %.not18 = icmp eq ptr %14, null
-  br i1 %.not18, label %20, label %15
-
-15:                                               ; preds = %get_functools_state_by_type.exit
-  %16 = load i32, ptr %14, align 8, !tbaa !21
-  %17 = icmp slt i32 %16, 0
-  br i1 %17, label %_Py_NewRef.exit, label %18
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %10) ]
+  %11 = getelementptr i8, ptr %10, i64 32
+  %.val.i = load ptr, ptr %11, align 8, !tbaa !4
+  %12 = getelementptr inbounds nuw i8, ptr %.val.i, i64 16
+  %13 = load ptr, ptr %12, align 8, !tbaa !16
+  %.not18 = icmp eq ptr %13, null
+  br i1 %.not18, label %19, label %14
+
+14:                                               ; preds = %get_functools_state_by_type.exit
+  %15 = load i32, ptr %13, align 8, !tbaa !21
+  %16 = icmp slt i32 %15, 0
+  br i1 %16, label %_Py_NewRef.exit, label %17
 
-18:                                               ; preds = %15
-  %19 = add nuw i32 %16, 1
-  store i32 %19, ptr %14, align 8, !tbaa !21
+18:                                               ; preds = %14
+  %19 = add nuw i32 %15, 1
+  store i32 %19, ptr %13, align 8, !tbaa !21
   br label %_Py_NewRef.exit
 
 20:                                               ; preds = %get_functools_state_by_type.exit
@@ -1895,7 +1894,7 @@ get_functools_state_by_type.exit:                 ; preds = %6, %5
   br i1 %22, label %_Py_NewRef.exit, label %23
 
 23:                                               ; preds = %20
-  %24 = load ptr, ptr %13, align 8, !tbaa !16
+  %24 = load ptr, ptr %12, align 8, !tbaa !16
   %25 = icmp eq ptr %24, null
   br i1 %25, label %26, label %_Py_NewRef.exit
 
@@ -1910,11 +1909,11 @@ get_functools_state_by_type.exit:                 ; preds = %6, %5
   br label %_Py_NewRef.exit20
 
 _Py_NewRef.exit20:                                ; preds = %26, %29
-  store ptr %21, ptr %13, align 8, !tbaa !16
+  store ptr %21, ptr %12, align 8, !tbaa !16
   br label %_Py_NewRef.exit
 
-_Py_NewRef.exit:                                  ; preds = %18, %15, %23, %_Py_NewRef.exit20, %20, %8
-  %.0 = phi ptr [ null, %8 ], [ %21, %23 ], [ null, %20 ], [ %21, %_Py_NewRef.exit20 ], [ %14, %15 ], [ %14, %18 ]
+_Py_NewRef.exit:                                  ; preds = %18, %14, %23, %_Py_NewRef.exit20, %20, %8
+  %.0 = phi ptr [ null, %8 ], [ %21, %22 ], [ null, %19 ], [ %21, %_Py_NewRef.exit20 ], [ %13, %14 ], [ %13, %17 ]
   ret ptr %.0
 }
 
diff --git a/bench/csmith/optimized/FactUnion.ll b/bench/csmith/optimized/FactUnion.ll
index 9c070843711..a5b55a32b60 100644
--- a/bench/csmith/optimized/FactUnion.ll
+++ b/bench/csmith/optimized/FactUnion.ll
@@ -234,12 +234,11 @@ _ZNSt6vectorIPK8VariableSaIS2_EED2Ev.exit:        ; preds = %27, %24
   %57 = getelementptr inbounds nuw i8, ptr %56, i64 208
   %58 = load ptr, ptr %57, align 8, !tbaa !60
   %59 = tail call noundef ptr @_Z30get_return_fact_for_invocationPK22FunctionInvocationUserPK8Variable13eFactCategory(ptr noundef nonnull %54, ptr noundef %58, i32 noundef 2)
-  %60 = icmp ne ptr %59, null
-  tail call void @llvm.assume(i1 %60)
-  %61 = tail call ptr @__dynamic_cast(ptr nonnull %59, ptr nonnull @_ZTI4Fact, ptr nonnull @_ZTI9FactUnion, i64 0) #16
-  %62 = getelementptr inbounds nuw i8, ptr %61, i64 24
-  %63 = load i32, ptr %62, align 8, !tbaa !15
-  tail call void @_ZN9FactUnion10make_factsERKSt6vectorIPK8VariableSaIS3_EEi(ptr dead_on_unwind writable sret(%"class.std::vector.7") align 8 %0, ptr noundef nonnull align 8 dereferenceable(24) %3, i32 noundef %63)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %59) ]
+  %60 = tail call ptr @__dynamic_cast(ptr nonnull %59, ptr nonnull @_ZTI4Fact, ptr nonnull @_ZTI9FactUnion, i64 0) #16
+  %61 = getelementptr inbounds nuw i8, ptr %60, i64 24
+  %62 = load i32, ptr %61, align 8, !tbaa !15
+  tail call void @_ZN9FactUnion10make_factsERKSt6vectorIPK8VariableSaIS3_EEi(ptr dead_on_unwind writable sret(%"class.std::vector.7") align 8 %0, ptr noundef nonnull align 8 dereferenceable(24) %3, i32 noundef %62)
   br label %_ZNSt6vectorIPK4FactSaIS2_EED2Ev.exit
 
 64:                                               ; preds = %tailrecurse
@@ -250,7 +249,7 @@ _ZNSt6vectorIPK8VariableSaIS2_EED2Ev.exit:        ; preds = %27, %24
   br label %tailrecurse.backedge
 
 tailrecurse.backedge:                             ; preds = %64, %69
-  %.tr79.be.in = phi ptr [ %68, %64 ], [ %71, %69 ]
+  %.tr79.be.in = phi ptr [ %68, %63 ], [ %71, %68 ]
   %.tr79.be = load ptr, ptr %.tr79.be.in, align 8, !tbaa !77
   br label %tailrecurse
 
@@ -934,8 +933,7 @@ _ZNK8Variable14is_union_fieldEv.exit.i:           ; preds = %tailrecurse.i
   br i1 %9, label %_ZNK8Variable21is_inside_union_fieldEv.exit.preheader, label %tailrecurse.i
 
 _ZNK8Variable21is_inside_union_fieldEv.exit.preheader: ; preds = %_ZNK8Variable14is_union_fieldEv.exit.i
-  %.not23 = icmp ne ptr %0, null
-  tail call void @llvm.assume(i1 %.not23)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   br label %.lr.ph
 
 .lr.ph:                                           ; preds = %_ZNK8Variable21is_inside_union_fieldEv.exit.preheader, %.lr.ph
diff --git a/bench/csmith/optimized/Variable.ll b/bench/csmith/optimized/Variable.ll
index 5e657a9ce92..1962a7e31e1 100644
--- a/bench/csmith/optimized/Variable.ll
+++ b/bench/csmith/optimized/Variable.ll
@@ -6663,7 +6663,8 @@ _ZNK8Variable14is_union_fieldEv.exit.i.i:         ; preds = %tailrecurse.i.i
   br i1 %116, label %117, label %tailrecurse.i.i
 
 117:                                              ; preds = %_ZNK8Variable14is_union_fieldEv.exit.i.i
-  %118 = load ptr, ptr %110, align 8, !tbaa !39, !nonnull !105, !noundef !105
+  %118 = load ptr, ptr %110, align 8, !tbaa !39
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %118) ]
   %119 = load i32, ptr %118, align 8, !tbaa !57
   %.not7.i6.i = icmp eq i32 %119, 2
   br i1 %.not7.i6.i, label %tailrecurse.i42, label %.preheader.i.i44
@@ -9798,7 +9799,8 @@ _ZNK8Variable14is_union_fieldEv.exit.i:           ; preds = %tailrecurse.i
   br i1 %8, label %9, label %tailrecurse.i
 
 9:                                                ; preds = %_ZNK8Variable14is_union_fieldEv.exit.i
-  %10 = load ptr, ptr %2, align 8, !tbaa !39, !nonnull !105, !noundef !105
+  %10 = load ptr, ptr %2, align 8, !tbaa !39
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %10) ]
   %11 = load i32, ptr %10, align 8, !tbaa !57
   %.not7.i6 = icmp eq i32 %11, 2
   br i1 %.not7.i6, label %tailrecurse, label %.preheader.i
diff --git a/bench/deku-rs/optimized/5vpv8kgcwbq2ocxo8cxpek7im.ll b/bench/deku-rs/optimized/5vpv8kgcwbq2ocxo8cxpek7im.ll
index bdf8e25708c..faf7b4a5012 100644
--- a/bench/deku-rs/optimized/5vpv8kgcwbq2ocxo8cxpek7im.ll
+++ b/bench/deku-rs/optimized/5vpv8kgcwbq2ocxo8cxpek7im.ll
@@ -208,9 +208,11 @@ _ZN4core3fmt9Formatter9write_fmt17h84cdd179c532562aE.exit: ; preds = %2
   store ptr %16, ptr %25, align 8
   %.sroa.423.0..sroa_idx = getelementptr inbounds nuw i8, ptr %18, i64 24
   store ptr @"_ZN4core3fmt3num3imp54_$LT$impl$u20$core..fmt..Display$u20$for$u20$usize$GT$3fmt17hd8f455fd1d89d1b2E", ptr %.sroa.423.0..sroa_idx, align 8
-  %.val = load ptr, ptr %1, align 8, !nonnull !4, !noundef !4
+  %.val = load ptr, ptr %1, align 8
   %26 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val24 = load ptr, ptr %26, align 8, !nonnull !4, !noundef !4
+  %.val24 = load ptr, ptr %26, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val24) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %7), !noalias !31
   store ptr @anon.add384122a720165492a0d3fd8ad951f.15, ptr %7, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %7, i64 8
@@ -236,9 +238,11 @@ _ZN4core3fmt9Formatter9write_fmt17h84cdd179c532562aE.exit41: ; preds = %2
   store ptr %15, ptr %14, align 8
   %.sroa.415.0..sroa_idx = getelementptr inbounds nuw i8, ptr %14, i64 8
   store ptr @"_ZN44_$LT$$RF$T$u20$as$u20$core..fmt..Display$GT$3fmt17h79d8723a8353efdbE", ptr %.sroa.415.0..sroa_idx, align 8
-  %.val35 = load ptr, ptr %1, align 8, !nonnull !4, !noundef !4
+  %.val35 = load ptr, ptr %1, align 8
   %29 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val36 = load ptr, ptr %29, align 8, !nonnull !4, !noundef !4
+  %.val36 = load ptr, ptr %29, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val35) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val36) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %6), !noalias !34
   store ptr @anon.add384122a720165492a0d3fd8ad951f.17, ptr %6, align 8
   %.sroa.568.0..sroa_idx = getelementptr inbounds nuw i8, ptr %6, i64 8
@@ -263,9 +267,11 @@ _ZN4core3fmt9Formatter9write_fmt17h84cdd179c532562aE.exit46: ; preds = %2
   store ptr %13, ptr %12, align 8
   %.sroa.411.0..sroa_idx = getelementptr inbounds nuw i8, ptr %12, i64 8
   store ptr @"_ZN44_$LT$$RF$T$u20$as$u20$core..fmt..Display$GT$3fmt17h79d8723a8353efdbE", ptr %.sroa.411.0..sroa_idx, align 8
-  %.val33 = load ptr, ptr %1, align 8, !nonnull !4, !noundef !4
+  %.val33 = load ptr, ptr %1, align 8
   %32 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val34 = load ptr, ptr %32, align 8, !nonnull !4, !noundef !4
+  %.val34 = load ptr, ptr %32, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val33) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val34) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %5), !noalias !37
   store ptr @anon.add384122a720165492a0d3fd8ad951f.19, ptr %5, align 8
   %.sroa.574.0..sroa_idx = getelementptr inbounds nuw i8, ptr %5, i64 8
@@ -290,9 +296,11 @@ _ZN4core3fmt9Formatter9write_fmt17h84cdd179c532562aE.exit51: ; preds = %2
   store ptr %11, ptr %10, align 8
   %.sroa.47.0..sroa_idx = getelementptr inbounds nuw i8, ptr %10, i64 8
   store ptr @"_ZN44_$LT$$RF$T$u20$as$u20$core..fmt..Display$GT$3fmt17h79d8723a8353efdbE", ptr %.sroa.47.0..sroa_idx, align 8
-  %.val31 = load ptr, ptr %1, align 8, !nonnull !4, !noundef !4
+  %.val31 = load ptr, ptr %1, align 8
   %35 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val32 = load ptr, ptr %35, align 8, !nonnull !4, !noundef !4
+  %.val32 = load ptr, ptr %35, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val31) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val32) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !40
   store ptr @anon.add384122a720165492a0d3fd8ad951f.21, ptr %4, align 8
   %.sroa.580.0..sroa_idx = getelementptr inbounds nuw i8, ptr %4, i64 8
@@ -310,18 +318,22 @@ _ZN4core3fmt9Formatter9write_fmt17h84cdd179c532562aE.exit51: ; preds = %2
   br label %_ZN4core3fmt9Formatter9write_fmt17h84cdd179c532562aE.exit56
 
 37:                                               ; preds = %2
-  %.val29 = load ptr, ptr %1, align 8, !nonnull !4, !noundef !4
+  %.val29 = load ptr, ptr %1, align 8
   %38 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val30 = load ptr, ptr %38, align 8, !nonnull !4, !noundef !4
+  %.val30 = load ptr, ptr %38, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val29) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val30) ]
   %39 = getelementptr inbounds nuw i8, ptr %.val30, i64 24
   %40 = load ptr, ptr %39, align 8, !invariant.load !4, !noalias !43, !nonnull !4
   %41 = tail call noundef zeroext i1 %40(ptr noundef nonnull align 1 %.val29, ptr noalias noundef nonnull readonly align 1 @anon.add384122a720165492a0d3fd8ad951f.22, i64 noundef 15), !noalias !43
   br label %_ZN4core3fmt9Formatter9write_fmt17h84cdd179c532562aE.exit56
 
 42:                                               ; preds = %2
-  %.val27 = load ptr, ptr %1, align 8, !nonnull !4, !noundef !4
+  %.val27 = load ptr, ptr %1, align 8
   %43 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val28 = load ptr, ptr %43, align 8, !nonnull !4, !noundef !4
+  %.val28 = load ptr, ptr %43, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val27) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val28) ]
   %44 = getelementptr inbounds nuw i8, ptr %.val28, i64 24
   %45 = load ptr, ptr %44, align 8, !invariant.load !4, !noalias !46, !nonnull !4
   %46 = tail call noundef zeroext i1 %45(ptr noundef nonnull align 1 %.val27, ptr noalias noundef nonnull readonly align 1 @anon.add384122a720165492a0d3fd8ad951f.24, i64 noundef 34), !noalias !46
@@ -335,9 +347,11 @@ _ZN4core3fmt9Formatter9write_fmt17h84cdd179c532562aE.exit66: ; preds = %2
   store ptr %9, ptr %8, align 8
   %.sroa.43.0..sroa_idx = getelementptr inbounds nuw i8, ptr %8, i64 8
   store ptr @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$GT$3fmt17h6998ef2b5006b15dE", ptr %.sroa.43.0..sroa_idx, align 8
-  %.val25 = load ptr, ptr %1, align 8, !nonnull !4, !noundef !4
+  %.val25 = load ptr, ptr %1, align 8
   %48 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val26 = load ptr, ptr %48, align 8, !nonnull !4, !noundef !4
+  %.val26 = load ptr, ptr %48, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val25) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val26) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !49
   store ptr @anon.add384122a720165492a0d3fd8ad951f.27, ptr %3, align 8
   %.sroa.598.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 8
@@ -452,6 +466,9 @@ declare noundef range(i32 0, 10) i32 @rust_eh_personality(i32 noundef, i32 nound
 ; Function Attrs: nonlazybind uwtable
 declare void @_ZN5alloc3fmt6format12format_inner17hbc00c97fd665fffbE(ptr dead_on_unwind noalias noundef writable sret([24 x i8]) align 8 captures(none) dereferenceable(24), ptr noalias noundef align 8 captures(none) dereferenceable(48)) unnamed_addr #0
 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #5
+
 ; Function Attrs: nonlazybind uwtable
 declare noundef zeroext i1 @"_ZN42_$LT$str$u20$as$u20$core..fmt..Display$GT$3fmt17h46a919a088a4abb1E"(ptr noalias noundef nonnull readonly align 1, i64 noundef, ptr noalias noundef align 8 dereferenceable(24)) unnamed_addr #0
 
@@ -496,8 +513,9 @@ attributes #1 = { mustprogress nofree norecurse nosync nounwind nonlazybind will
 attributes #2 = { inlinehint nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #3 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #4 = { nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #5 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
-attributes #6 = { noreturn }
+attributes #5 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: write) }
+attributes #6 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
+attributes #7 = { noreturn }
 
 !llvm.module.flags = !{!0, !1}
 !llvm.ident = !{!2}
diff --git a/bench/delta-rs/optimized/2x36mf26z3hhv78u.ll b/bench/delta-rs/optimized/2x36mf26z3hhv78u.ll
index d7cdf4e648c..c9cf5bda534 100644
--- a/bench/delta-rs/optimized/2x36mf26z3hhv78u.ll
+++ b/bench/delta-rs/optimized/2x36mf26z3hhv78u.ll
@@ -3097,13 +3097,12 @@ define hidden noundef range(i8 0, 3) i8 @"_ZN22aws_smithy_runtime_api6client12in
   %4 = alloca { i64, [42 x i64] }, align 8
   %5 = getelementptr inbounds nuw i8, ptr %0, i64 344
   %6 = load i64, ptr %5, align 8, !range !6, !noundef !5
-  %7 = icmp ne i64 %6, 2
+  %7 = icmp eq i64 %6, 2
   %8 = getelementptr inbounds nuw i8, ptr %0, i64 1056
   %9 = load i8, ptr %8, align 8, !range !84, !noundef !5
   %10 = trunc nuw i8 %9 to i1
-  %.not1 = xor i1 %10, true
-  %brmerge = or i1 %7, %.not1
-  br i1 %brmerge, label %11, label %12
+  %brmerge.not = and i1 %7, %10
+  br i1 %brmerge.not, label %12, label %11
 
 11:                                               ; preds = %2
   br i1 %10, label %14, label %13
@@ -3117,7 +3116,6 @@ define hidden noundef range(i8 0, 3) i8 @"_ZN22aws_smithy_runtime_api6client12in
   br label %12
 
 14:                                               ; preds = %11
-  tail call void @llvm.assume(i1 %7)
   call void @_ZN22aws_smithy_runtime_api4http7request7Request9try_clone17h6791bb70b2509758E(ptr noalias noundef nonnull sret({ i64, [42 x i64] }) align 8 captures(none) dereferenceable(344) %4, ptr noundef nonnull align 8 %5)
   %15 = getelementptr inbounds nuw i8, ptr %0, i64 1057
   store i8 2, ptr %15, align 1
diff --git a/bench/delta-rs/optimized/52n0zllxvyme4vg7.ll b/bench/delta-rs/optimized/52n0zllxvyme4vg7.ll
index cbed0b731b6..3c521aa6a3e 100644
--- a/bench/delta-rs/optimized/52n0zllxvyme4vg7.ll
+++ b/bench/delta-rs/optimized/52n0zllxvyme4vg7.ll
@@ -791,6 +791,7 @@ define hidden noundef zeroext i1 @"_ZN48_$LT$$u5b$T$u5d$$u20$as$u20$core..fmt..D
   call void @llvm.lifetime.start.p0(ptr nonnull %5)
   call void @_ZN4core3fmt9Formatter10debug_list17he7f95665c58b7f1eE(ptr noalias noundef nonnull sret({ { ptr, i8, i8, [6 x i8] } }) align 8 captures(none) dereferenceable(16) %5, ptr noalias noundef nonnull align 8 dereferenceable(64) %2)
   %6 = getelementptr inbounds i8, ptr %0, i64 %1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
   %7 = icmp eq i64 %1, 0
   br i1 %7, label %_ZN4core3fmt8builders9DebugList7entries17hc9b6119b1b27d029E.exit, label %.lr.ph.i
 
@@ -1853,6 +1854,7 @@ define hidden noundef zeroext i1 @"_ZN80_$LT$std..io..Write..write_fmt..Adapter$
 
 16:                                               ; preds = %11
   %.val.i = load ptr, ptr %9, align 8, !noalias !268, !nonnull !4, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   %17 = ptrtoint ptr %.val.i to i64
   %18 = and i64 %17, 3
   switch i64 %18, label %default.unreachable [
@@ -2006,6 +2008,7 @@ define hidden void @"_ZN15deltalake_mount4file14regular_rename28_$u7b$$u7b$closu
   %25 = load ptr, ptr %24, align 8, !alias.scope !309, !noalias !312, !nonnull !4, !noundef !4
   call void @llvm.lifetime.end.p0(ptr nonnull %12), !noalias !300
   call void @llvm.lifetime.start.p0(ptr nonnull %11), !noalias !314
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %25) ]
   invoke void @_ZN3std2io5error14repr_bitpacked11decode_repr17h7f8e389ca306a717E.llvm.16543861533300112609(ptr noalias noundef nonnull sret({ i8, [15 x i8] }) align 8 captures(none) dereferenceable(16) %11, ptr noundef nonnull %25)
           to label %.noexc26 unwind label %21
 
@@ -2127,6 +2130,7 @@ _ZN3std2fs6rename17hfdc0114d0fce9968E.exit:       ; preds = %46
   call void @llvm.lifetime.end.p0(ptr nonnull %9), !noalias !345
   call void @llvm.lifetime.end.p0(ptr nonnull %8), !noalias !345
   %.val.i.i = load ptr, ptr %10, align 8, !noalias !345, !nonnull !4, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i.i) ]
   %63 = ptrtoint ptr %.val.i.i to i64
   %64 = and i64 %63, 3
   switch i64 %64, label %default.unreachable [
diff --git a/bench/diesel-rs/optimized/qtsoo9cro2f5z9.ll b/bench/diesel-rs/optimized/qtsoo9cro2f5z9.ll
index c24a7c41edc..a9f8c6bd996 100644
--- a/bench/diesel-rs/optimized/qtsoo9cro2f5z9.ll
+++ b/bench/diesel-rs/optimized/qtsoo9cro2f5z9.ll
@@ -572,6 +572,7 @@ define hidden void @_ZN25diesel_table_macro_syntax8take_lit17h33c0a88e25bfec0dE(
   br i1 %31, label %"_ZN25diesel_table_macro_syntax8take_lit28_$u7b$$u7b$closure$u7d$$u7d$17hd19b4a66119bc535E.exit.thread.i", label %"_ZN25diesel_table_macro_syntax8take_lit28_$u7b$$u7b$closure$u7d$$u7d$17hd19b4a66119bc535E.exit.i"
 
 "_ZN25diesel_table_macro_syntax8take_lit28_$u7b$$u7b$closure$u7d$$u7d$17hd19b4a66119bc535E.exit.i": ; preds = %23
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %14) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %8), !noalias !70
   store ptr %2, ptr %8, align 8, !noalias !70
   store i64 %3, ptr %22, align 8, !noalias !70
@@ -892,6 +893,7 @@ define hidden void @_ZN25diesel_table_macro_syntax8take_lit17hfb9bb12205efe714E(
   br i1 %31, label %"_ZN25diesel_table_macro_syntax8take_lit28_$u7b$$u7b$closure$u7d$$u7d$17hb928ac29e79f69e7E.exit.thread.i", label %"_ZN25diesel_table_macro_syntax8take_lit28_$u7b$$u7b$closure$u7d$$u7d$17hb928ac29e79f69e7E.exit.i"
 
 "_ZN25diesel_table_macro_syntax8take_lit28_$u7b$$u7b$closure$u7d$$u7d$17hb928ac29e79f69e7E.exit.i": ; preds = %23
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %14) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %8), !noalias !108
   store ptr %2, ptr %8, align 8, !noalias !108
   store i64 %3, ptr %22, align 8, !noalias !108
diff --git a/bench/egg-rs/optimized/1m5ocab1mrcx5l24.ll b/bench/egg-rs/optimized/1m5ocab1mrcx5l24.ll
index 43f0a7defd8..13d50c936a1 100644
--- a/bench/egg-rs/optimized/1m5ocab1mrcx5l24.ll
+++ b/bench/egg-rs/optimized/1m5ocab1mrcx5l24.ll
@@ -88,7 +88,7 @@ define hidden noundef nonnull align 8 dereferenceable(56) ptr @"_ZN84_$LT$alloc.
   br i1 %6, label %"_ZN75_$LT$usize$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$9index_mut17h3bffe445e68c4870E.llvm.16079354848027093366.exit", label %7, !prof !10
 
 7:                                                ; preds = %3
-  tail call void @_ZN4core9panicking18panic_bounds_check17hd7e618b1b39cc1c3E(i64 noundef %1, i64 noundef %5, ptr noalias noundef nonnull readonly align 8 dereferenceable(24) %2) #10, !noalias !11
+  tail call void @_ZN4core9panicking18panic_bounds_check17hd7e618b1b39cc1c3E(i64 noundef %1, i64 noundef %5, ptr noalias noundef nonnull readonly align 8 dereferenceable(24) %2) #11, !noalias !11
   unreachable
 
 "_ZN75_$LT$usize$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$9index_mut17h3bffe445e68c4870E.llvm.16079354848027093366.exit": ; preds = %3
@@ -112,7 +112,7 @@ define hidden noundef nonnull align 8 dereferenceable(40) ptr @"_ZN8indexmap3map
   br i1 %9, label %"_ZN84_$LT$alloc..vec..Vec$LT$T$C$A$GT$$u20$as$u20$core..ops..index..IndexMut$LT$I$GT$$GT$9index_mut17hc19996dc9490530eE.llvm.16079354848027093366.exit", label %10, !prof !10
 
 10:                                               ; preds = %1
-  tail call void @_ZN4core9panicking18panic_bounds_check17hd7e618b1b39cc1c3E(i64 noundef %5, i64 noundef %8, ptr noalias noundef nonnull readonly align 8 dereferenceable(24) @anon.281238473684458937f08731efa41452.7.llvm.16079354848027093366) #10, !noalias !19
+  tail call void @_ZN4core9panicking18panic_bounds_check17hd7e618b1b39cc1c3E(i64 noundef %5, i64 noundef %8, ptr noalias noundef nonnull readonly align 8 dereferenceable(24) @anon.281238473684458937f08731efa41452.7.llvm.16079354848027093366) #11, !noalias !19
   unreachable
 
 "_ZN84_$LT$alloc..vec..Vec$LT$T$C$A$GT$$u20$as$u20$core..ops..index..IndexMut$LT$I$GT$$GT$9index_mut17hc19996dc9490530eE.llvm.16079354848027093366.exit": ; preds = %1
@@ -313,9 +313,11 @@ _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i:
   %.sroa.46.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 24
   store ptr @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$GT$3fmt17h29975e959083d87cE", ptr %.sroa.46.0..sroa_idx, align 8
   %8 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %8, align 8, !nonnull !4, !noundef !4
+  %.val = load ptr, ptr %8, align 8
   %9 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val7 = load ptr, ptr %9, align 8, !nonnull !4, !noundef !4
+  %.val7 = load ptr, ptr %9, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val7) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !56
   store ptr @anon.281238473684458937f08731efa41452.10, ptr %2, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
@@ -370,6 +372,9 @@ declare noundef i32 @rust_eh_personality(i32 noundef, i32 noundef, i64 noundef,
 ; Function Attrs: cold noreturn nounwind nonlazybind uwtable
 declare void @_ZN4core9panicking16panic_in_cleanup17hd62aa59d1fda1c9fE() unnamed_addr #7
 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #8
+
 ; Function Attrs: nonlazybind uwtable
 declare noundef zeroext i1 @"_ZN73_$LT$symbol_table..global..GlobalSymbol$u20$as$u20$core..fmt..Display$GT$3fmt17hbdf2ce995d09039dE"(ptr noalias noundef readonly align 4 dereferenceable(4), ptr noalias noundef align 8 dereferenceable(64)) unnamed_addr #0
 
@@ -405,11 +410,12 @@ attributes #4 = { mustprogress nofree norecurse nosync nounwind nonlazybind will
 attributes #5 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
 attributes #6 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #7 = { cold noreturn nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #8 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
+attributes #8 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: write) }
 attributes #9 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
-attributes #10 = { noreturn }
-attributes #11 = { cold }
-attributes #12 = { cold noreturn nounwind }
+attributes #10 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #11 = { noreturn }
+attributes #12 = { cold }
+attributes #13 = { cold noreturn nounwind }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/egg-rs/optimized/2fp1d0strj8iokyf.ll b/bench/egg-rs/optimized/2fp1d0strj8iokyf.ll
index 1bee66b018e..286a80e5b44 100644
--- a/bench/egg-rs/optimized/2fp1d0strj8iokyf.ll
+++ b/bench/egg-rs/optimized/2fp1d0strj8iokyf.ll
@@ -37,6 +37,7 @@ define hidden { ptr, i64 } @"_ZN4core3str21_$LT$impl$u20$str$GT$12trim_matches17
 5:                                                ; preds = %"_ZN81_$LT$core..str..pattern..CharSearcher$u20$as$u20$core..str..pattern..Searcher$GT$4next17hcd7a1fbf0842f8b6E.llvm.6823518425481094615.exit.i", %"_ZN52_$LT$char$u20$as$u20$core..str..pattern..Pattern$GT$13into_searcher17h3b0bc60b23cdc925E.llvm.6823518425481094615.exit"
   %.sroa.6.0 = phi i64 [ 0, %"_ZN52_$LT$char$u20$as$u20$core..str..pattern..Pattern$GT$13into_searcher17h3b0bc60b23cdc925E.llvm.6823518425481094615.exit" ], [ %50, %"_ZN81_$LT$core..str..pattern..CharSearcher$u20$as$u20$core..str..pattern..Searcher$GT$4next17hcd7a1fbf0842f8b6E.llvm.6823518425481094615.exit.i" ]
   %6 = getelementptr inbounds i8, ptr %0, i64 %.sroa.6.0
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
   %7 = icmp eq i64 %.sroa.6.0, %1
   br i1 %7, label %_ZN4core3str7pattern8Searcher11next_reject17hda43b8b455e3452aE.llvm.6823518425481094615.exit, label %8
 
@@ -53,6 +54,7 @@ define hidden { ptr, i64 } @"_ZN4core3str21_$LT$impl$u20$str$GT$12trim_matches17
   %15 = icmp ne i64 %14, %1
   tail call void @llvm.assume(i1 %15)
   %16 = getelementptr inbounds nuw i8, ptr %6, i64 2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %9) ]
   %17 = load i8, ptr %9, align 1, !noalias !4, !noundef !15
   %18 = shl nuw nsw i32 %13, 6
   %19 = and i8 %17, 63
@@ -70,6 +72,7 @@ define hidden { ptr, i64 } @"_ZN4core3str21_$LT$impl$u20$str$GT$12trim_matches17
   %26 = icmp ne i64 %25, %1
   tail call void @llvm.assume(i1 %26)
   %27 = getelementptr inbounds nuw i8, ptr %6, i64 3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %16) ]
   %28 = load i8, ptr %16, align 1, !noalias !4, !noundef !15
   %29 = shl nuw nsw i32 %20, 6
   %30 = and i8 %28, 63
@@ -85,6 +88,7 @@ define hidden { ptr, i64 } @"_ZN4core3str21_$LT$impl$u20$str$GT$12trim_matches17
   %37 = icmp ne i64 %36, %1
   tail call void @llvm.assume(i1 %37)
   %38 = getelementptr inbounds nuw i8, ptr %6, i64 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %27) ]
   %39 = load i8, ptr %27, align 1, !noalias !4, !noundef !15
   %40 = shl nuw nsw i32 %13, 18
   %41 = and i32 %40, 1835008
@@ -111,6 +115,7 @@ _ZN4core3str7pattern8Searcher11next_reject17hda43b8b455e3452aE.llvm.682351842548
   %.sroa.614.0 = phi i64 [ %50, %"_ZN81_$LT$core..str..pattern..CharSearcher$u20$as$u20$core..str..pattern..Searcher$GT$4next17hcd7a1fbf0842f8b6E.llvm.6823518425481094615.exit.i" ], [ undef, %5 ], [ undef, %"_ZN81_$LT$core..str..iter..Chars$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17h917887c7fa076885E.exit.i.i" ]
   %storemerge.i = phi i1 [ true, %"_ZN81_$LT$core..str..pattern..CharSearcher$u20$as$u20$core..str..pattern..Searcher$GT$4next17hcd7a1fbf0842f8b6E.llvm.6823518425481094615.exit.i" ], [ false, %5 ], [ false, %"_ZN81_$LT$core..str..iter..Chars$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17h917887c7fa076885E.exit.i.i" ]
   %51 = getelementptr inbounds i8, ptr %0, i64 %.sroa.6.1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %51) ]
   %52 = ptrtoint ptr %51 to i64
   %53 = sub i64 %.sroa.6.1, %52
   br label %54
@@ -132,6 +137,7 @@ _ZN4core3str7pattern8Searcher11next_reject17hda43b8b455e3452aE.llvm.682351842548
   %63 = icmp ne i64 %.sroa.6.1, %62
   tail call void @llvm.assume(i1 %63)
   %64 = getelementptr inbounds i8, ptr %56, i64 -2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %64) ]
   %65 = load i8, ptr %64, align 1, !noalias !16, !noundef !15
   %66 = and i8 %65, 31
   %67 = zext nneg i8 %66 to i32
@@ -147,6 +153,7 @@ _ZN4core3str7pattern8Searcher11next_reject17hda43b8b455e3452aE.llvm.682351842548
   %71 = icmp ne i64 %.sroa.6.1, %70
   tail call void @llvm.assume(i1 %71)
   %72 = getelementptr inbounds i8, ptr %56, i64 -3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %72) ]
   %73 = load i8, ptr %72, align 1, !noalias !16, !noundef !15
   %74 = and i8 %73, 15
   %75 = zext nneg i8 %74 to i32
@@ -158,6 +165,7 @@ _ZN4core3str7pattern8Searcher11next_reject17hda43b8b455e3452aE.llvm.682351842548
   %78 = icmp ne i64 %.sroa.6.1, %77
   tail call void @llvm.assume(i1 %78)
   %79 = getelementptr inbounds i8, ptr %56, i64 -4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %79) ]
   %80 = load i8, ptr %79, align 1, !noalias !16, !noundef !15
   %81 = and i8 %80, 7
   %82 = zext nneg i8 %81 to i32
@@ -229,6 +237,7 @@ define hidden void @_ZN4core3str7pattern15ReverseSearcher16next_reject_back17h5e
   %5 = getelementptr inbounds nuw i8, ptr %1, i64 16
   %6 = load i64, ptr %5, align 8, !alias.scope !27, !noalias !30, !noundef !15
   %7 = getelementptr inbounds i8, ptr %4, i64 %6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %7) ]
   %8 = ptrtoint ptr %7 to i64
   %.promoted = load i64, ptr %3, align 8, !alias.scope !27, !noalias !30
   %9 = getelementptr inbounds nuw i8, ptr %1, i64 36
@@ -253,6 +262,7 @@ define hidden void @_ZN4core3str7pattern15ReverseSearcher16next_reject_back17h5e
   %20 = icmp ne i64 %6, %19
   tail call void @llvm.assume(i1 %20)
   %21 = getelementptr inbounds i8, ptr %13, i64 -2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %21) ]
   %22 = load i8, ptr %21, align 1, !noalias !34, !noundef !15
   %23 = and i8 %22, 31
   %24 = zext nneg i8 %23 to i32
@@ -268,6 +278,7 @@ define hidden void @_ZN4core3str7pattern15ReverseSearcher16next_reject_back17h5e
   %28 = icmp ne i64 %6, %27
   tail call void @llvm.assume(i1 %28)
   %29 = getelementptr inbounds i8, ptr %13, i64 -3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %29) ]
   %30 = load i8, ptr %29, align 1, !noalias !34, !noundef !15
   %31 = and i8 %30, 15
   %32 = zext nneg i8 %31 to i32
@@ -279,6 +290,7 @@ define hidden void @_ZN4core3str7pattern15ReverseSearcher16next_reject_back17h5e
   %35 = icmp ne i64 %6, %34
   tail call void @llvm.assume(i1 %35)
   %36 = getelementptr inbounds i8, ptr %13, i64 -4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %36) ]
   %37 = load i8, ptr %36, align 1, !noalias !34, !noundef !15
   %38 = and i8 %37, 7
   %39 = zext nneg i8 %38 to i32
@@ -347,6 +359,7 @@ define hidden void @_ZN4core3str7pattern8Searcher11next_reject17hda43b8b455e3452
   %12 = phi i64 [ %57, %"_ZN81_$LT$core..str..pattern..CharSearcher$u20$as$u20$core..str..pattern..Searcher$GT$4next17hcd7a1fbf0842f8b6E.llvm.6823518425481094615.exit" ], [ %.promoted, %2 ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !39)
   %13 = getelementptr inbounds i8, ptr %4, i64 %12
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %13) ]
   %14 = icmp eq i64 %12, %6
   br i1 %14, label %"_ZN81_$LT$core..str..pattern..CharSearcher$u20$as$u20$core..str..pattern..Searcher$GT$4next17hcd7a1fbf0842f8b6E.llvm.6823518425481094615.exit.thread", label %15
 
@@ -363,6 +376,7 @@ define hidden void @_ZN4core3str7pattern8Searcher11next_reject17hda43b8b455e3452
   %22 = icmp ne i64 %21, %6
   tail call void @llvm.assume(i1 %22)
   %23 = getelementptr inbounds nuw i8, ptr %13, i64 2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %16) ]
   %24 = load i8, ptr %16, align 1, !noalias !44, !noundef !15
   %25 = shl nuw nsw i32 %20, 6
   %26 = and i8 %24, 63
@@ -380,6 +394,7 @@ define hidden void @_ZN4core3str7pattern8Searcher11next_reject17hda43b8b455e3452
   %33 = icmp ne i64 %32, %6
   tail call void @llvm.assume(i1 %33)
   %34 = getelementptr inbounds nuw i8, ptr %13, i64 3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %23) ]
   %35 = load i8, ptr %23, align 1, !noalias !44, !noundef !15
   %36 = shl nuw nsw i32 %27, 6
   %37 = and i8 %35, 63
@@ -395,6 +410,7 @@ define hidden void @_ZN4core3str7pattern8Searcher11next_reject17hda43b8b455e3452
   %44 = icmp ne i64 %43, %6
   tail call void @llvm.assume(i1 %44)
   %45 = getelementptr inbounds nuw i8, ptr %13, i64 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %34) ]
   %46 = load i8, ptr %34, align 1, !noalias !44, !noundef !15
   %47 = shl nuw nsw i32 %20, 18
   %48 = and i32 %47, 1835008
@@ -669,6 +685,7 @@ define hidden void @"_ZN81_$LT$core..str..pattern..CharSearcher$u20$as$u20$core.
   %7 = load i64, ptr %6, align 8, !noundef !15
   %8 = getelementptr inbounds i8, ptr %5, i64 %4
   %9 = getelementptr inbounds i8, ptr %5, i64 %7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   %10 = ptrtoint ptr %9 to i64
   %11 = icmp eq i64 %4, %7
   br i1 %11, label %"_ZN81_$LT$core..str..iter..Chars$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17h917887c7fa076885E.exit.thread11", label %12
@@ -686,6 +703,7 @@ define hidden void @"_ZN81_$LT$core..str..pattern..CharSearcher$u20$as$u20$core.
   %19 = icmp ne i64 %18, %7
   tail call void @llvm.assume(i1 %19)
   %20 = getelementptr inbounds nuw i8, ptr %8, i64 2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %13) ]
   %21 = load i8, ptr %13, align 1, !noalias !49, !noundef !15
   %22 = shl nuw nsw i32 %17, 6
   %23 = and i8 %21, 63
@@ -703,6 +721,7 @@ define hidden void @"_ZN81_$LT$core..str..pattern..CharSearcher$u20$as$u20$core.
   %30 = icmp ne i64 %29, %7
   tail call void @llvm.assume(i1 %30)
   %31 = getelementptr inbounds nuw i8, ptr %8, i64 3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %20) ]
   %32 = load i8, ptr %20, align 1, !noalias !49, !noundef !15
   %33 = shl nuw nsw i32 %24, 6
   %34 = and i8 %32, 63
@@ -718,6 +737,7 @@ define hidden void @"_ZN81_$LT$core..str..pattern..CharSearcher$u20$as$u20$core.
   %41 = icmp ne i64 %40, %7
   tail call void @llvm.assume(i1 %41)
   %42 = getelementptr inbounds nuw i8, ptr %8, i64 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %31) ]
   %43 = load i8, ptr %31, align 1, !noalias !49, !noundef !15
   %44 = shl nuw nsw i32 %17, 18
   %45 = and i32 %44, 1835008
@@ -761,6 +781,7 @@ define hidden void @"_ZN88_$LT$core..str..pattern..CharSearcher$u20$as$u20$core.
   %7 = load i64, ptr %6, align 8, !noundef !15
   %8 = getelementptr inbounds i8, ptr %5, i64 %7
   %9 = getelementptr inbounds i8, ptr %5, i64 %4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   %10 = ptrtoint ptr %8 to i64
   %11 = icmp eq i64 %7, %4
   br i1 %11, label %"_ZN96_$LT$core..str..iter..Chars$u20$as$u20$core..iter..traits..double_ended..DoubleEndedIterator$GT$9next_back17h189d834bc25f9481E.exit.thread", label %12
@@ -776,6 +797,7 @@ define hidden void @"_ZN88_$LT$core..str..pattern..CharSearcher$u20$as$u20$core.
   %17 = icmp ne i64 %7, %16
   tail call void @llvm.assume(i1 %17)
   %18 = getelementptr inbounds i8, ptr %9, i64 -2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %18) ]
   %19 = load i8, ptr %18, align 1, !noalias !54, !noundef !15
   %20 = and i8 %19, 31
   %21 = zext nneg i8 %20 to i32
@@ -791,6 +813,7 @@ define hidden void @"_ZN88_$LT$core..str..pattern..CharSearcher$u20$as$u20$core.
   %25 = icmp ne i64 %7, %24
   tail call void @llvm.assume(i1 %25)
   %26 = getelementptr inbounds i8, ptr %9, i64 -3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %26) ]
   %27 = load i8, ptr %26, align 1, !noalias !54, !noundef !15
   %28 = and i8 %27, 15
   %29 = zext nneg i8 %28 to i32
@@ -802,6 +825,7 @@ define hidden void @"_ZN88_$LT$core..str..pattern..CharSearcher$u20$as$u20$core.
   %32 = icmp ne i64 %7, %31
   tail call void @llvm.assume(i1 %32)
   %33 = getelementptr inbounds i8, ptr %9, i64 -4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %33) ]
   %34 = load i8, ptr %33, align 1, !noalias !54, !noundef !15
   %35 = and i8 %34, 7
   %36 = zext nneg i8 %35 to i32
diff --git a/bench/egg-rs/optimized/c6cke9vz8fsxl18.ll b/bench/egg-rs/optimized/c6cke9vz8fsxl18.ll
index 8e7a0d95e1a..96000c18959 100644
--- a/bench/egg-rs/optimized/c6cke9vz8fsxl18.ll
+++ b/bench/egg-rs/optimized/c6cke9vz8fsxl18.ll
@@ -12,6 +12,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %.val = load ptr, ptr %4, align 8, !nonnull !4, !noundef !4
   %5 = getelementptr i8, ptr %3, i64 16
   %.val1 = load i64, ptr %5, align 8, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %6 = tail call noundef zeroext i1 @"_ZN40_$LT$str$u20$as$u20$core..fmt..Debug$GT$3fmt17hbb23b6687f8daeb3E"(ptr noalias noundef nonnull readonly align 1 %.val, i64 noundef %.val1, ptr noalias noundef nonnull align 8 dereferenceable(64) %1)
   ret i1 %6
 }
@@ -197,6 +198,9 @@ declare void @llvm.lifetime.start.p0(ptr captures(none)) #4
 ; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite)
 declare void @llvm.lifetime.end.p0(ptr captures(none)) #4
 
+; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #5
+
 ; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite)
 declare void @llvm.experimental.noalias.scope.decl(metadata) #5
 
@@ -205,7 +209,8 @@ attributes #1 = { inlinehint nonlazybind uwtable "probe-stack"="inline-asm" "tar
 attributes #2 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
 attributes #3 = { cold nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #4 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
-attributes #5 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #5 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #6 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/egg-rs/optimized/ptoyfq63qf7sowp.ll b/bench/egg-rs/optimized/ptoyfq63qf7sowp.ll
index 17721080409..720a5e7689c 100644
--- a/bench/egg-rs/optimized/ptoyfq63qf7sowp.ll
+++ b/bench/egg-rs/optimized/ptoyfq63qf7sowp.ll
@@ -47,10 +47,8 @@ target triple = "x86_64-unknown-linux-gnu"
 define internal fastcc noundef zeroext i1 @_ZN4core3fmt9Formatter9write_fmt17h221a3e46c5f11a57E(ptr %.32.val, ptr %.40.val, ptr noalias noundef nonnull readonly align 8 captures(none) dereferenceable(48) %0) unnamed_addr #0 {
 _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit:
   %1 = alloca [48 x i8], align 8
-  %2 = icmp ne ptr %.32.val, null
-  tail call void @llvm.assume(i1 %2)
-  %3 = icmp ne ptr %.40.val, null
-  tail call void @llvm.assume(i1 %3)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.32.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.40.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %1)
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(48) %1, ptr noundef nonnull align 8 dereferenceable(48) %0, i64 48, i1 false)
   %4 = call noundef zeroext i1 @_ZN4core3fmt5write17hc090a2ffd6b28c4aE(ptr noundef nonnull align 1 %.32.val, ptr noalias noundef nonnull readonly align 8 dereferenceable(24) %.40.val, ptr noalias noundef nonnull align 8 captures(none) dereferenceable(48) %1)
@@ -388,15 +386,19 @@ _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i:
   %22 = alloca [16 x i8], align 8
   %23 = alloca [16 x i8], align 8
   %24 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val169 = load ptr, ptr %24, align 8, !nonnull !14, !noundef !14
+  %.val169 = load ptr, ptr %24, align 8
   %25 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val170 = load ptr, ptr %25, align 8, !nonnull !14, !noundef !14
+  %.val170 = load ptr, ptr %25, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val169) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val170) ]
   %26 = getelementptr inbounds nuw i8, ptr %.val170, i64 24
   %27 = load ptr, ptr %26, align 8, !invariant.load !14, !noalias !124, !nonnull !14
   %28 = tail call noundef zeroext i1 %27(ptr noundef nonnull align 1 %.val169, ptr noalias noundef nonnull readonly align 1 @anon.b1f18bcfaa6eebcdd00c9bf773d8bb51.12, i64 noundef 14), !noalias !124
   br i1 %28, label %95, label %_ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i171
 
 _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i171: ; preds = %_ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val169) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val170) ]
   %29 = tail call noundef zeroext i1 %27(ptr noundef nonnull align 1 %.val169, ptr noalias noundef nonnull readonly align 1 @anon.b1f18bcfaa6eebcdd00c9bf773d8bb51.14, i64 noundef 14), !noalias !127
   br i1 %29, label %95, label %_ZN4core3fmt9Formatter9write_fmt17h221a3e46c5f11a57E.exit182
 
@@ -405,6 +407,8 @@ _ZN4core3fmt9Formatter9write_fmt17h221a3e46c5f11a57E.exit182: ; preds = %_ZN4cor
   store ptr %0, ptr %23, align 8
   %.sroa.488.0..sroa_idx = getelementptr inbounds nuw i8, ptr %23, i64 8
   store ptr @"_ZN57_$LT$egg..run..StopReason$u20$as$u20$core..fmt..Debug$GT$3fmt17h05e07cc7d21ba61eE", ptr %.sroa.488.0..sroa_idx, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val169) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val170) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !130
   store ptr @anon.b1f18bcfaa6eebcdd00c9bf773d8bb51.18, ptr %3, align 8
   %.sroa.5200.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 8
@@ -426,6 +430,8 @@ _ZN4core3fmt9Formatter9write_fmt17h221a3e46c5f11a57E.exit188: ; preds = %_ZN4cor
   store ptr %31, ptr %22, align 8
   %.sroa.492.0..sroa_idx = getelementptr inbounds nuw i8, ptr %22, i64 8
   store ptr @"_ZN4core3fmt3num3imp54_$LT$impl$u20$core..fmt..Display$u20$for$u20$usize$GT$3fmt17h7e93687954fa76c5E", ptr %.sroa.492.0..sroa_idx, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val169) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val170) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !133
   store ptr @anon.b1f18bcfaa6eebcdd00c9bf773d8bb51.20, ptr %2, align 8
   %.sroa.5206.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
diff --git a/bench/faiss/optimized/IVFlib.ll b/bench/faiss/optimized/IVFlib.ll
index dae2a07da8c..40c8890bd5d 100644
--- a/bench/faiss/optimized/IVFlib.ll
+++ b/bench/faiss/optimized/IVFlib.ll
@@ -740,27 +740,26 @@ _ZNSt10unique_ptrIA_fSt14default_deleteIS0_EE5resetIPfvEEvT_.exit: ; preds = %6
   %.sroa.0.0 = phi ptr [ null, %6 ], [ %9, %_ZNSt10unique_ptrIA_fSt14default_deleteIS0_EE5resetIPfvEEvT_.exit ], [ null, %4 ]
   %.015 = phi ptr [ %1, %6 ], [ %9, %_ZNSt10unique_ptrIA_fSt14default_deleteIS0_EE5resetIPfvEEvT_.exit ], [ %1, %4 ]
   %.0 = phi ptr [ %0, %6 ], [ %11, %_ZNSt10unique_ptrIA_fSt14default_deleteIS0_EE5resetIPfvEEvT_.exit ], [ null, %4 ]
-  %12 = icmp ne ptr %.0, null
-  tail call void @llvm.assume(i1 %12)
-  %13 = tail call ptr @__dynamic_cast(ptr nonnull %.0, ptr nonnull @_ZTIN5faiss5IndexE, ptr nonnull @_ZTIN5faiss8IndexIVFE, i64 0) #20
-  %14 = getelementptr inbounds nuw i8, ptr %13, i64 48
-  %15 = load ptr, ptr %14, align 8, !tbaa !36
-  %16 = sext i32 %2 to i64
-  %17 = load ptr, ptr %15, align 8, !tbaa !32
-  %18 = getelementptr inbounds nuw i8, ptr %17, i64 56
-  %19 = load ptr, ptr %18, align 8
-  invoke void %19(ptr noundef nonnull align 8 dereferenceable(36) %15, i64 noundef %16, ptr noundef %.015, ptr noundef %3, i64 noundef 1)
-          to label %20 unwind label %21
-
-20:                                               ; preds = %.thread
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.0) ]
+  %12 = tail call ptr @__dynamic_cast(ptr nonnull %.0, ptr nonnull @_ZTIN5faiss5IndexE, ptr nonnull @_ZTIN5faiss8IndexIVFE, i64 0) #20
+  %13 = getelementptr inbounds nuw i8, ptr %12, i64 48
+  %14 = load ptr, ptr %13, align 8, !tbaa !36
+  %15 = sext i32 %2 to i64
+  %16 = load ptr, ptr %14, align 8, !tbaa !32
+  %17 = getelementptr inbounds nuw i8, ptr %16, i64 56
+  %18 = load ptr, ptr %17, align 8
+  invoke void %18(ptr noundef nonnull align 8 dereferenceable(36) %14, i64 noundef %15, ptr noundef %.015, ptr noundef %3, i64 noundef 1)
+          to label %19 unwind label %20
+
+19:                                               ; preds = %.thread
   %.not.i = icmp eq ptr %.sroa.0.0, null
   br i1 %.not.i, label %_ZNSt10unique_ptrIA_fSt14default_deleteIS0_EED2Ev.exit, label %_ZNKSt14default_deleteIA_fEclIfEENSt9enable_ifIXsr14is_convertibleIPA_T_PS0_EE5valueEvE4typeEPS4_.exit.i
 
-_ZNKSt14default_deleteIA_fEclIfEENSt9enable_ifIXsr14is_convertibleIPA_T_PS0_EE5valueEvE4typeEPS4_.exit.i: ; preds = %20
+_ZNKSt14default_deleteIA_fEclIfEENSt9enable_ifIXsr14is_convertibleIPA_T_PS0_EE5valueEvE4typeEPS4_.exit.i: ; preds = %19
   tail call void @_ZdaPv(ptr noundef nonnull %.sroa.0.0) #27
   br label %_ZNSt10unique_ptrIA_fSt14default_deleteIS0_EED2Ev.exit
 
-_ZNSt10unique_ptrIA_fSt14default_deleteIS0_EED2Ev.exit: ; preds = %20, %_ZNKSt14default_deleteIA_fEclIfEENSt9enable_ifIXsr14is_convertibleIPA_T_PS0_EE5valueEvE4typeEPS4_.exit.i
+_ZNSt10unique_ptrIA_fSt14default_deleteIS0_EED2Ev.exit: ; preds = %19, %_ZNKSt14default_deleteIA_fEclIfEENSt9enable_ifIXsr14is_convertibleIPA_T_PS0_EE5valueEvE4typeEPS4_.exit.i
   ret void
 
 21:                                               ; preds = %.thread
diff --git a/bench/fish-rs/optimized/czc1lx326fyc2pd0sgvwfm67e.ll b/bench/fish-rs/optimized/czc1lx326fyc2pd0sgvwfm67e.ll
index b3ead9873f3..17514707e6e 100644
--- a/bench/fish-rs/optimized/czc1lx326fyc2pd0sgvwfm67e.ll
+++ b/bench/fish-rs/optimized/czc1lx326fyc2pd0sgvwfm67e.ll
@@ -85,6 +85,7 @@ define { ptr, i64 } @"_ZN91_$LT$$RF$widestring..utfstr..Utf32Str$u20$as$u20$fish
 .lr.ph.i.i.i:                                     ; preds = %.lr.ph.i.i.i.preheader, %"_ZN115_$LT$core..iter..adapters..take_while..TakeWhile$LT$I$C$P$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$8try_fold5check28_$u7b$$u7b$closure$u7d$$u7d$17h915bea6934e9cd93E.exit.i.i.i"
   %.sroa.01.018.i.i.i = phi i64 [ %14, %"_ZN115_$LT$core..iter..adapters..take_while..TakeWhile$LT$I$C$P$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$8try_fold5check28_$u7b$$u7b$closure$u7d$$u7d$17h915bea6934e9cd93E.exit.i.i.i" ], [ 0, %.lr.ph.i.i.i.preheader ]
   %11 = phi ptr [ %13, %"_ZN115_$LT$core..iter..adapters..take_while..TakeWhile$LT$I$C$P$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$8try_fold5check28_$u7b$$u7b$closure$u7d$$u7d$17h915bea6934e9cd93E.exit.i.i.i" ], [ %3, %.lr.ph.i.i.i.preheader ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %11) ]
   %12 = load i32, ptr %11, align 4, !range !5, !alias.scope !7, !noalias !10, !noundef !3
   %.not.i.i.i.i = icmp eq i32 %12, 37
   br i1 %.not.i.i.i.i, label %"_ZN115_$LT$core..iter..adapters..take_while..TakeWhile$LT$I$C$P$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h3d88d3c339f7a055E.exit", label %"_ZN115_$LT$core..iter..adapters..take_while..TakeWhile$LT$I$C$P$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$8try_fold5check28_$u7b$$u7b$closure$u7d$$u7d$17h915bea6934e9cd93E.exit.i.i.i"
@@ -113,6 +114,7 @@ define { ptr, i64 } @"_ZN91_$LT$$RF$widestring..utfstr..Utf32Str$u20$as$u20$fish
 .lr.ph.i.i.i6:                                    ; preds = %.lr.ph.i.i.i6.preheader, %"_ZN115_$LT$core..iter..adapters..take_while..TakeWhile$LT$I$C$P$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$8try_fold5check28_$u7b$$u7b$closure$u7d$$u7d$17h24347fdb85971813E.exit.i.i.i"
   %.sroa.01.018.i.i.i7 = phi i64 [ %23, %"_ZN115_$LT$core..iter..adapters..take_while..TakeWhile$LT$I$C$P$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$8try_fold5check28_$u7b$$u7b$closure$u7d$$u7d$17h24347fdb85971813E.exit.i.i.i" ], [ 0, %.lr.ph.i.i.i6.preheader ]
   %19 = phi ptr [ %22, %"_ZN115_$LT$core..iter..adapters..take_while..TakeWhile$LT$I$C$P$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$8try_fold5check28_$u7b$$u7b$closure$u7d$$u7d$17h24347fdb85971813E.exit.i.i.i" ], [ %18, %.lr.ph.i.i.i6.preheader ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %19) ]
   %20 = load i32, ptr %19, align 4, !range !5, !alias.scope !19, !noalias !22, !noundef !3
   %21 = icmp eq i32 %20, 37
   br i1 %21, label %"_ZN115_$LT$core..iter..adapters..take_while..TakeWhile$LT$I$C$P$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$8try_fold5check28_$u7b$$u7b$closure$u7d$$u7d$17h24347fdb85971813E.exit.i.i.i", label %"_ZN115_$LT$core..iter..adapters..take_while..TakeWhile$LT$I$C$P$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17hb9cfb931e4583b18E.exit"
@@ -151,7 +153,7 @@ define { ptr, i64 } @"_ZN91_$LT$$RF$widestring..utfstr..Utf32Str$u20$as$u20$fish
   br i1 %36, label %37, label %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h18ff10cb156c632fE.exit", !prof !6
 
 37:                                               ; preds = %30
-  tail call void @_ZN4core5slice5index24slice_end_index_len_fail17h295f890f9c88ef86E(i64 noundef %35, i64 noundef %5, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.db5b5264aa4d041cff4cacb9b40c1303.3) #6, !noalias !30
+  tail call void @_ZN4core5slice5index24slice_end_index_len_fail17h295f890f9c88ef86E(i64 noundef %35, i64 noundef %5, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.db5b5264aa4d041cff4cacb9b40c1303.3) #7, !noalias !30
   unreachable
 
 "_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h18ff10cb156c632fE.exit": ; preds = %30
@@ -171,6 +173,9 @@ declare void @_ZN4core5slice5index24slice_end_index_len_fail17h295f890f9c88ef86E
 ; Function Attrs: nounwind nonlazybind uwtable
 declare noundef range(i32 0, 10) i32 @rust_eh_personality(i32 noundef, i32 noundef, i64 noundef, ptr noundef, ptr noundef) unnamed_addr #5
 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #6
+
 ; Function Attrs: cold noreturn nonlazybind uwtable
 declare void @_ZN4core6option13expect_failed17h89918c64c89b4471E(ptr noalias noundef nonnull readonly align 1, i64 noundef, ptr noalias noundef readonly align 8 dereferenceable(24)) unnamed_addr #4
 
@@ -186,7 +191,8 @@ attributes #2 = { mustprogress nofree norecurse nosync nounwind nonlazybind will
 attributes #3 = { nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #4 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #5 = { nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #6 = { noreturn }
+attributes #6 = { mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #7 = { noreturn }
 
 !llvm.module.flags = !{!0, !1}
 !llvm.ident = !{!2}
diff --git a/bench/fish-rs/optimized/dtp7ktj49b8sopaubz8bv9d8a.ll b/bench/fish-rs/optimized/dtp7ktj49b8sopaubz8bv9d8a.ll
index 72d8f4424fc..d51796d8a0b 100644
--- a/bench/fish-rs/optimized/dtp7ktj49b8sopaubz8bv9d8a.ll
+++ b/bench/fish-rs/optimized/dtp7ktj49b8sopaubz8bv9d8a.ll
@@ -223,6 +223,7 @@ define noundef range(i32 0, 1114113) i32 @"_ZN66_$LT$$RF$str$u20$as$u20$fish_pri
 .lr.ph.i:                                         ; preds = %10
   %.sroa.4.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %3, i64 8
   %.sroa.5.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %3, i64 16
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.5.0..sroa_idx.i) ]
   br label %16
 
 .loopexit.i:                                      ; preds = %38, %.lr.ph40.i, %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17ha21ba39c927a9d87E.exit.thread.i", %2
@@ -259,9 +260,9 @@ define noundef range(i32 0, 1114113) i32 @"_ZN66_$LT$$RF$str$u20$as$u20$fish_pri
   call void @llvm.experimental.noalias.scope.decl(metadata !11)
   br label %.lr.ph.i.i.i
 
-.lr.ph.i.i.i:                                     ; preds = %.lr.ph.i.i.i, %17
-  %.sroa.0.08.i.i.i = phi i8 [ %22, %.lr.ph.i.i.i ], [ 0, %17 ]
-  %18 = phi i64 [ %19, %.lr.ph.i.i.i ], [ 0, %17 ]
+.lr.ph.i.i.i:                                     ; preds = %17, %.lr.ph.i.i.i
+  %.sroa.0.08.i.i.i = phi i8 [ 0, %.lr.ph.i.i.i ], [ %22, %17 ]
+  %18 = phi i64 [ 0, %.lr.ph.i.i.i ], [ %19, %17 ]
   %19 = add nuw nsw i64 %18, 1
   %20 = getelementptr inbounds nuw i8, ptr %.sroa.5.0..sroa_idx.i, i64 %18
   %21 = load i8, ptr %20, align 1, !range !13, !alias.scope !14, !noalias !17, !noundef !3
@@ -347,6 +348,7 @@ define noundef range(i32 0, 1114113) i32 @"_ZN66_$LT$$RF$str$u20$as$u20$fish_pri
   %56 = zext nneg i8 %55 to i32
   %57 = icmp ne ptr %54, %8
   call void @llvm.assume(i1 %57)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %54) ]
   %58 = load i8, ptr %54, align 1, !noalias !20, !noundef !3
   %59 = shl nuw nsw i32 %56, 6
   %60 = and i8 %58, 63
@@ -363,6 +365,7 @@ define noundef range(i32 0, 1114113) i32 @"_ZN66_$LT$$RF$str$u20$as$u20$fish_pri
   %66 = getelementptr inbounds nuw i8, ptr %.sroa.0.3.ph, i64 2
   %67 = icmp ne ptr %66, %8
   call void @llvm.assume(i1 %67)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %66) ]
   %68 = load i8, ptr %66, align 1, !noalias !20, !noundef !3
   %69 = shl nuw nsw i32 %61, 6
   %70 = and i8 %68, 63
@@ -377,6 +380,7 @@ define noundef range(i32 0, 1114113) i32 @"_ZN66_$LT$$RF$str$u20$as$u20$fish_pri
   %76 = getelementptr inbounds nuw i8, ptr %.sroa.0.3.ph, i64 3
   %77 = icmp ne ptr %76, %8
   call void @llvm.assume(i1 %77)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %76) ]
   %78 = load i8, ptr %76, align 1, !noalias !20, !noundef !3
   %79 = shl nuw nsw i32 %56, 18
   %80 = and i32 %79, 1835008
@@ -427,12 +431,14 @@ define void @"_ZN66_$LT$$RF$str$u20$as$u20$fish_printf..printf_impl..FormatStrin
   %16 = icmp ne ptr %13, %7
   tail call void @llvm.assume(i1 %16)
   %17 = getelementptr inbounds nuw i8, ptr %.sroa.0.013, i64 2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %13) ]
   %18 = icmp samesign ugt i8 %14, -33
   br i1 %18, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17hd348f569470c642bE.exit14.i", label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17hd348f569470c642bE.exit16.i"
 
 "_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17hd348f569470c642bE.exit14.i": ; preds = %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17hd348f569470c642bE.exit12.i"
   %19 = icmp ne ptr %17, %7
   tail call void @llvm.assume(i1 %19)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %17) ]
   %20 = icmp samesign ugt i8 %14, -17
   %spec.select.v = select i1 %20, i64 4, i64 3
   %spec.select = getelementptr inbounds nuw i8, ptr %.sroa.0.013, i64 %spec.select.v
@@ -483,6 +489,7 @@ define { ptr, i64 } @"_ZN66_$LT$$RF$str$u20$as$u20$fish_printf..printf_impl..For
   %14 = icmp ne ptr %9, %7
   tail call void @llvm.assume(i1 %14)
   %15 = getelementptr inbounds nuw i8, ptr %8, i64 2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %9) ]
   %16 = load i8, ptr %9, align 1, !noalias !26, !noundef !3
   %17 = shl nuw nsw i32 %13, 6
   %18 = and i8 %16, 63
@@ -499,6 +506,7 @@ define { ptr, i64 } @"_ZN66_$LT$$RF$str$u20$as$u20$fish_printf..printf_impl..For
   %24 = icmp ne ptr %15, %7
   tail call void @llvm.assume(i1 %24)
   %25 = getelementptr inbounds nuw i8, ptr %8, i64 3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %15) ]
   %26 = load i8, ptr %15, align 1, !noalias !26, !noundef !3
   %27 = shl nuw nsw i32 %19, 6
   %28 = and i8 %26, 63
@@ -513,6 +521,7 @@ define { ptr, i64 } @"_ZN66_$LT$$RF$str$u20$as$u20$fish_printf..printf_impl..For
   %34 = icmp ne ptr %25, %7
   tail call void @llvm.assume(i1 %34)
   %35 = getelementptr inbounds nuw i8, ptr %8, i64 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %25) ]
   %36 = load i8, ptr %25, align 1, !noalias !26, !noundef !3
   %37 = shl nuw nsw i32 %13, 18
   %38 = and i32 %37, 1835008
@@ -591,6 +600,7 @@ define { ptr, i64 } @"_ZN66_$LT$$RF$str$u20$as$u20$fish_printf..printf_impl..For
   %67 = icmp ne ptr %62, %7
   tail call void @llvm.assume(i1 %67)
   %68 = getelementptr inbounds nuw i8, ptr %61, i64 2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %62) ]
   %69 = load i8, ptr %62, align 1, !noalias !41, !noundef !3
   %70 = shl nuw nsw i32 %66, 6
   %71 = and i8 %69, 63
@@ -607,6 +617,7 @@ define { ptr, i64 } @"_ZN66_$LT$$RF$str$u20$as$u20$fish_printf..printf_impl..For
   %77 = icmp ne ptr %68, %7
   tail call void @llvm.assume(i1 %77)
   %78 = getelementptr inbounds nuw i8, ptr %61, i64 3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %68) ]
   %79 = load i8, ptr %68, align 1, !noalias !41, !noundef !3
   %80 = shl nuw nsw i32 %72, 6
   %81 = and i8 %79, 63
@@ -621,6 +632,7 @@ define { ptr, i64 } @"_ZN66_$LT$$RF$str$u20$as$u20$fish_printf..printf_impl..For
   %87 = icmp ne ptr %78, %7
   tail call void @llvm.assume(i1 %87)
   %88 = getelementptr inbounds nuw i8, ptr %61, i64 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %78) ]
   %89 = load i8, ptr %78, align 1, !noalias !41, !noundef !3
   %90 = shl nuw nsw i32 %66, 18
   %91 = and i32 %90, 1835008
diff --git a/bench/folly/optimized/CPUThreadPoolExecutor.ll b/bench/folly/optimized/CPUThreadPoolExecutor.ll
index 20837f77591..fb5fd195bb6 100644
--- a/bench/folly/optimized/CPUThreadPoolExecutor.ll
+++ b/bench/folly/optimized/CPUThreadPoolExecutor.ll
@@ -5610,6 +5610,7 @@ _ZN5folly3f146detail8F14ChunkIPKvE6setTagEmm.exit.i: ; preds = %100
   %109 = getelementptr inbounds nuw %"union.std::aligned_storage<8, 8>::type", ptr %108, i64 %102
   %110 = icmp ne ptr %.029.i, @_ZZN5folly3f146detail20getF14EmptyTagVectorEvE8instance
   call void @llvm.assume(i1 %110)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %109) ]
   store ptr %.0.i.i.i.i, ptr %109, align 8, !tbaa !323, !noalias !320
   %111 = lshr i64 %102, 1
   %112 = ptrtoint ptr %109 to i64
@@ -6738,6 +6739,7 @@ _ZN5folly3f146detail8F14TableINS1_20ValueContainerPolicyIPKvvvvvEEE16initializeC
   %57 = getelementptr inbounds nuw %"union.std::aligned_storage<8, 8>::type", ptr %45, i64 %.042133
   call void @llvm.assume(i1 %46)
   %58 = getelementptr inbounds nuw %"union.std::aligned_storage<8, 8>::type", ptr %47, i64 %.0134
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %57) ]
   %59 = load ptr, ptr %58, align 8, !tbaa !323
   store ptr %59, ptr %57, align 8, !tbaa !323
   %60 = add nuw i64 %.042133, 1
@@ -6938,6 +6940,7 @@ _ZN5folly3f146detail8F14ChunkIPKvE25incrOutboundOverflowCountEv.exit.i: ; preds
   %152 = getelementptr inbounds nuw %"union.std::aligned_storage<8, 8>::type", ptr %151, i64 %141
   %153 = icmp ne ptr %.lcssa21.i, @_ZZN5folly3f146detail20getF14EmptyTagVectorEvE8instance
   call void @llvm.assume(i1 %153)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %152) ]
   %154 = load ptr, ptr %98, align 8, !tbaa !323
   store ptr %154, ptr %152, align 8, !tbaa !323
   %.not118 = icmp eq i32 %.sroa.081.1, 0
diff --git a/bench/g2o/optimized/optimizable_graph.ll b/bench/g2o/optimized/optimizable_graph.ll
index c77f7b4b258..dfdce89c8fb 100644
--- a/bench/g2o/optimized/optimizable_graph.ll
+++ b/bench/g2o/optimized/optimizable_graph.ll
@@ -3852,7 +3852,8 @@ _ZNSt8_Rb_treeIPN3g2o16OptimizableGraph6VertexES3_St9_IdentityIS3_ENS1_15VertexI
   %.sroa.15.2 = phi ptr [ %.sroa.15.3, %_ZNSt20back_insert_iteratorISt6vectorIPN3g2o10HyperGraph4EdgeESaIS4_EEEaSERKS4_.exit.i ], [ null, %._crit_edge92 ]
   %.sroa.03.08.i = phi ptr [ %108, %_ZNSt20back_insert_iteratorISt6vectorIPN3g2o10HyperGraph4EdgeESaIS4_EEEaSERKS4_.exit.i ], [ %72, %._crit_edge92 ]
   %79 = getelementptr inbounds nuw i8, ptr %.sroa.03.08.i, i64 32
-  %80 = load ptr, ptr %79, align 8, !tbaa !134, !nonnull !87, !noundef !87
+  %80 = load ptr, ptr %79, align 8, !tbaa !134
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %80) ]
   %81 = call ptr @__dynamic_cast(ptr nonnull readonly %80, ptr nonnull @_ZTIN3g2o10HyperGraph4EdgeE, ptr nonnull @_ZTIN3g2o16OptimizableGraph4EdgeE, i64 0) #46
   %82 = getelementptr inbounds nuw i8, ptr %81, i64 60
   %83 = load i32, ptr %82, align 4, !tbaa !60
diff --git a/bench/graphviz/optimized/mainwindow.ll b/bench/graphviz/optimized/mainwindow.ll
index 88c47887cec..ea03d2dcdba 100644
--- a/bench/graphviz/optimized/mainwindow.ll
+++ b/bench/graphviz/optimized/mainwindow.ll
@@ -7917,8 +7917,7 @@ _ZN11CMainWindow14activeMdiChildEv.exit:          ; preds = %13, %15
 19:                                               ; preds = %_ZN11CMainWindow14activeMdiChildEv.exit
   %20 = load ptr, ptr %3, align 8, !tbaa !48
   %21 = tail call noundef ptr @_ZNK8QMdiArea15activeSubWindowEv(ptr noundef nonnull align 8 dereferenceable(40) %20)
-  %.not.not.i2 = icmp ne ptr %21, null
-  tail call void @llvm.assume(i1 %.not.not.i2)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %21) ]
   %22 = tail call noundef ptr @_ZNK13QMdiSubWindow6widgetEv(ptr noundef nonnull align 8 dereferenceable(40) %21)
   %23 = load ptr, ptr %22, align 8, !tbaa !46
   %24 = getelementptr inbounds nuw i8, ptr %23, i64 8
@@ -8066,8 +8065,7 @@ _ZN11CMainWindow14activeMdiChildEv.exit:          ; preds = %13, %15
 19:                                               ; preds = %_ZN11CMainWindow14activeMdiChildEv.exit
   %20 = load ptr, ptr %3, align 8, !tbaa !48
   %21 = tail call noundef ptr @_ZNK8QMdiArea15activeSubWindowEv(ptr noundef nonnull align 8 dereferenceable(40) %20)
-  %.not.not.i2 = icmp ne ptr %21, null
-  tail call void @llvm.assume(i1 %.not.not.i2)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %21) ]
   %22 = tail call noundef ptr @_ZNK13QMdiSubWindow6widgetEv(ptr noundef nonnull align 8 dereferenceable(40) %21)
   %23 = load ptr, ptr %22, align 8, !tbaa !46
   %24 = getelementptr inbounds nuw i8, ptr %23, i64 8
@@ -8181,8 +8179,7 @@ _ZN11CMainWindow14activeMdiChildEv.exit:          ; preds = %12, %14
 18:                                               ; preds = %_ZN11CMainWindow14activeMdiChildEv.exit
   %19 = load ptr, ptr %2, align 8, !tbaa !48
   %20 = tail call noundef ptr @_ZNK8QMdiArea15activeSubWindowEv(ptr noundef nonnull align 8 dereferenceable(40) %19)
-  %.not.not.i1 = icmp ne ptr %20, null
-  tail call void @llvm.assume(i1 %.not.not.i1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %20) ]
   %21 = tail call noundef ptr @_ZNK13QMdiSubWindow6widgetEv(ptr noundef nonnull align 8 dereferenceable(40) %20)
   %22 = load ptr, ptr %21, align 8, !tbaa !46
   %23 = getelementptr inbounds nuw i8, ptr %22, i64 8
@@ -8249,8 +8246,7 @@ _ZN11CMainWindow14activeMdiChildEv.exit:          ; preds = %12, %14
 18:                                               ; preds = %_ZN11CMainWindow14activeMdiChildEv.exit
   %19 = load ptr, ptr %2, align 8, !tbaa !48
   %20 = tail call noundef ptr @_ZNK8QMdiArea15activeSubWindowEv(ptr noundef nonnull align 8 dereferenceable(40) %19)
-  %.not.not.i1 = icmp ne ptr %20, null
-  tail call void @llvm.assume(i1 %.not.not.i1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %20) ]
   %21 = tail call noundef ptr @_ZNK13QMdiSubWindow6widgetEv(ptr noundef nonnull align 8 dereferenceable(40) %20)
   %22 = load ptr, ptr %21, align 8, !tbaa !46
   %23 = getelementptr inbounds nuw i8, ptr %22, i64 8
@@ -8317,8 +8313,7 @@ _ZN11CMainWindow14activeMdiChildEv.exit:          ; preds = %12, %14
 18:                                               ; preds = %_ZN11CMainWindow14activeMdiChildEv.exit
   %19 = load ptr, ptr %2, align 8, !tbaa !48
   %20 = tail call noundef ptr @_ZNK8QMdiArea15activeSubWindowEv(ptr noundef nonnull align 8 dereferenceable(40) %19)
-  %.not.not.i1 = icmp ne ptr %20, null
-  tail call void @llvm.assume(i1 %.not.not.i1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %20) ]
   %21 = tail call noundef ptr @_ZNK13QMdiSubWindow6widgetEv(ptr noundef nonnull align 8 dereferenceable(40) %20)
   %22 = load ptr, ptr %21, align 8, !tbaa !46
   %23 = getelementptr inbounds nuw i8, ptr %22, i64 8
@@ -8564,8 +8559,7 @@ _ZN11CMainWindow14activeMdiChildEv.exit:          ; preds = %1, %18, %20
           to label %.noexc unwind label %93
 
 .noexc:                                           ; preds = %24
-  %.not.not.i12 = icmp ne ptr %28, null
-  tail call void @llvm.assume(i1 %.not.not.i12)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %28) ]
   %29 = invoke noundef ptr @_ZNK13QMdiSubWindow6widgetEv(ptr noundef nonnull align 8 dereferenceable(40) %28)
           to label %.noexc15 unwind label %93
 
@@ -9037,8 +9031,7 @@ _ZN11CMainWindow14activeMdiChildEv.exit.thread:   ; preds = %1, %_ZN11CMainWindo
   call void @llvm.lifetime.start.p0(ptr nonnull %2)
   %68 = load ptr, ptr %3, align 8, !tbaa !48
   %69 = tail call noundef ptr @_ZNK8QMdiArea15activeSubWindowEv(ptr noundef nonnull align 8 dereferenceable(40) %68)
-  %.not.not.i2 = icmp ne ptr %69, null
-  tail call void @llvm.assume(i1 %.not.not.i2)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %69) ]
   %70 = tail call noundef ptr @_ZNK13QMdiSubWindow6widgetEv(ptr noundef nonnull align 8 dereferenceable(40) %69)
   %71 = load ptr, ptr %70, align 8, !tbaa !46
   %72 = getelementptr inbounds nuw i8, ptr %71, i64 8
diff --git a/bench/html5ever-rs/optimized/126f7y4y0nk6dpjh.ll b/bench/html5ever-rs/optimized/126f7y4y0nk6dpjh.ll
index df5a01adcb6..b6ec58d5a68 100644
--- a/bench/html5ever-rs/optimized/126f7y4y0nk6dpjh.ll
+++ b/bench/html5ever-rs/optimized/126f7y4y0nk6dpjh.ll
@@ -997,6 +997,7 @@ _ZN4core5slice4sort20provide_sorted_batch17hfc511b2652135f95E.exit: ; preds = %_
   br label %.invoke293
 
 158:                                              ; preds = %155
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre) ]
   %159 = getelementptr inbounds { i64, i64 }, ptr %.pre, i64 %.sroa.4.0.i56.ph
   %160 = load i64, ptr %159, align 8, !noundef !16
   %161 = getelementptr inbounds nuw i8, ptr %159, i64 8
@@ -1028,6 +1029,7 @@ _ZN4core5slice4sort20provide_sorted_batch17hfc511b2652135f95E.exit: ; preds = %_
   unreachable
 
 167:                                              ; preds = %158
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre) ]
   %168 = getelementptr inbounds { i64, i64 }, ptr %.pre, i64 %163
   %169 = load i64, ptr %168, align 8, !noundef !16
   %170 = getelementptr inbounds nuw i8, ptr %168, i64 8
@@ -1113,6 +1115,7 @@ _ZN4core5slice4sort20provide_sorted_batch17hfc511b2652135f95E.exit: ; preds = %_
   %.02823.i = phi ptr [ %210, %207 ], [ %184, %192 ]
   %.sroa.0.222.i = phi ptr [ %213, %207 ], [ %16, %192 ]
   %.sroa.18.321.i = phi ptr [ %208, %207 ], [ %183, %192 ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.222.i) ]
   %206 = invoke fastcc noundef zeroext i1 @_ZN4core3ops8function5FnMut8call_mut17h2ba0d34c37be0f42E(ptr noundef nonnull align 8 %.02823.i, ptr noundef nonnull align 8 %.sroa.0.222.i)
           to label %207 unwind label %.loopexit.split-lp.i
 
@@ -1148,7 +1151,7 @@ _ZN4core5slice4sort20provide_sorted_batch17hfc511b2652135f95E.exit: ; preds = %_
   %217 = ptrtoint ptr %.sroa.10.2.i to i64
   %218 = ptrtoint ptr %.sroa.0.1.i68 to i64
   %219 = sub nuw i64 %217, %218
-  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 8 %.sroa.18.2.i, ptr align 8 %.sroa.0.1.i68, i64 %219, i1 false), !noalias !154
+  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 8 %.sroa.18.2.i, ptr nonnull align 8 %.sroa.0.1.i68, i64 %219, i1 false), !noalias !154
   br label %.body
 
 "_ZN4core5slice4sort10merge_sort37RunVec$LT$RunAllocF$C$RunDeallocF$GT$6remove17h0f724e5ad5439e18E.exit": ; preds = %207, %199, %192, %187
@@ -1158,7 +1161,8 @@ _ZN4core5slice4sort20provide_sorted_batch17hfc511b2652135f95E.exit: ; preds = %_
   %220 = ptrtoint ptr %.sroa.10.1.i to i64
   %221 = ptrtoint ptr %.sroa.0.0.i66 to i64
   %222 = sub nuw i64 %220, %221
-  tail call void @llvm.memcpy.p0.p0.i64(ptr align 8 %.sroa.18.1.i, ptr align 8 %.sroa.0.0.i66, i64 %222, i1 false), !noalias !159
+  tail call void @llvm.memcpy.p0.p0.i64(ptr align 8 %.sroa.18.1.i, ptr nonnull align 8 %.sroa.0.0.i66, i64 %222, i1 false), !noalias !159
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre) ]
   %223 = add i64 %169, %160
   store i64 %223, ptr %168, align 8
   store i64 %162, ptr %170, align 8
diff --git a/bench/html5ever-rs/optimized/3n74qlghvzguzx1d.ll b/bench/html5ever-rs/optimized/3n74qlghvzguzx1d.ll
index 2378e31e86c..a3749c16b65 100644
--- a/bench/html5ever-rs/optimized/3n74qlghvzguzx1d.ll
+++ b/bench/html5ever-rs/optimized/3n74qlghvzguzx1d.ll
@@ -58,6 +58,7 @@ define hidden noundef zeroext i1 @"_ZN48_$LT$$u5b$T$u5d$$u20$as$u20$core..fmt..D
   call void @_ZN4core3fmt9Formatter10debug_list17h1616b9a56f5bf339E(ptr noalias noundef nonnull sret({ { ptr, i8, i8, [6 x i8] } }) align 8 captures(none) dereferenceable(16) %5, ptr noalias noundef nonnull align 8 dereferenceable(64) %2)
   %.idx = mul nsw i64 %1, 40
   %6 = getelementptr inbounds i8, ptr %0, i64 %.idx
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
   %7 = icmp eq i64 %1, 0
   br i1 %7, label %_ZN4core3fmt8builders9DebugList7entries17h4c9f8454ccc349d4E.exit, label %.lr.ph.i
 
@@ -446,6 +447,9 @@ declare noundef zeroext i1 @_ZN4core3fmt9Formatter9write_fmt17heacf5dba8c40948fE
 ; Function Attrs: nonlazybind uwtable
 declare noundef i32 @rust_eh_personality(i32 noundef, i32 noundef, i64 noundef, ptr noundef, ptr noundef) unnamed_addr #0
 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #8
+
 ; Function Attrs: nonlazybind uwtable
 declare noundef align 8 dereferenceable(16) ptr @_ZN4core3fmt8builders9DebugList5entry17h2ed5a4f4153b90ddE(ptr noalias noundef align 8 dereferenceable(16), ptr noundef nonnull align 1, ptr noalias noundef readonly align 8 dereferenceable(24)) unnamed_addr #0
 
@@ -472,10 +476,11 @@ attributes #4 = { mustprogress nofree norecurse nosync nounwind nonlazybind will
 attributes #5 = { inlinehint mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #6 = { mustprogress nofree norecurse nounwind nonlazybind willreturn memory(argmem: readwrite) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #7 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #8 = { cold nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #9 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
+attributes #8 = { mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #9 = { cold nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #10 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
-attributes #11 = { noreturn }
+attributes #11 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #12 = { noreturn }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/html5ever-rs/optimized/43v1czcn8mbp77o0.ll b/bench/html5ever-rs/optimized/43v1czcn8mbp77o0.ll
index 5b36b757243..57462d4e97b 100644
--- a/bench/html5ever-rs/optimized/43v1czcn8mbp77o0.ll
+++ b/bench/html5ever-rs/optimized/43v1czcn8mbp77o0.ll
@@ -44,6 +44,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   store i64 %10, ptr %6, align 8, !noalias !6
   %11 = getelementptr inbounds nuw i8, ptr %6, i64 8
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
   store ptr %11, ptr %4, align 8, !noalias !6
   %12 = getelementptr inbounds nuw i8, ptr %4, i64 8
   store ptr %6, ptr %12, align 8, !noalias !6
@@ -308,6 +309,7 @@ define hidden noundef zeroext i1 @"_ZN65_$LT$core..cell..RefCell$LT$T$GT$$u20$as
   store i64 %9, ptr %0, align 8
   %10 = getelementptr inbounds nuw i8, ptr %0, i64 8
   call void @llvm.lifetime.start.p0(ptr nonnull %4)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   store ptr %10, ptr %4, align 8
   %11 = getelementptr inbounds nuw i8, ptr %4, i64 8
   store ptr %0, ptr %11, align 8
@@ -374,6 +376,7 @@ define hidden noundef zeroext i1 @"_ZN65_$LT$core..cell..RefCell$LT$T$GT$$u20$as
   store i64 %9, ptr %0, align 8
   %10 = getelementptr inbounds nuw i8, ptr %0, i64 8
   call void @llvm.lifetime.start.p0(ptr nonnull %4)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   store ptr %10, ptr %4, align 8
   %11 = getelementptr inbounds nuw i8, ptr %4, i64 8
   store ptr %0, ptr %11, align 8
@@ -440,6 +443,7 @@ define hidden noundef zeroext i1 @"_ZN65_$LT$core..cell..RefCell$LT$T$GT$$u20$as
   store i64 %9, ptr %0, align 8
   %10 = getelementptr inbounds nuw i8, ptr %0, i64 8
   call void @llvm.lifetime.start.p0(ptr nonnull %4)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   store ptr %10, ptr %4, align 8
   %11 = getelementptr inbounds nuw i8, ptr %4, i64 8
   store ptr %0, ptr %11, align 8
@@ -553,6 +557,9 @@ declare void @llvm.lifetime.start.p0(ptr captures(none)) #3
 ; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite)
 declare void @llvm.lifetime.end.p0(ptr captures(none)) #3
 
+; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #4
+
 ; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite)
 declare void @llvm.experimental.noalias.scope.decl(metadata) #4
 
@@ -560,7 +567,8 @@ attributes #0 = { nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x
 attributes #1 = { inlinehint mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #2 = { inlinehint nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #3 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
-attributes #4 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #4 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #5 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/hyper-rs/optimized/4hz5u2ddz2sd8g08.ll b/bench/hyper-rs/optimized/4hz5u2ddz2sd8g08.ll
index 06c9d699203..dd397a57961 100644
--- a/bench/hyper-rs/optimized/4hz5u2ddz2sd8g08.ll
+++ b/bench/hyper-rs/optimized/4hz5u2ddz2sd8g08.ll
@@ -50,6 +50,7 @@ define hidden { i64, ptr } @"_ZN82_$LT$hyper..common..io..rewind..Rewind$LT$T$GT
   %21 = sub i64 %18, %20
   %.0.sroa.speculated.i = tail call noundef i64 @llvm.umin.i64(i64 range(i64 1, 0) %8, i64 %21)
   %22 = load ptr, ptr %10, align 8, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   %23 = add i64 %.0.sroa.speculated.i, %20
   %24 = load ptr, ptr %2, align 8, !noalias !13, !nonnull !4, !align !16, !noundef !4
   %25 = icmp ugt i64 %20, %23
@@ -232,6 +233,9 @@ declare void @llvm.experimental.noalias.scope.decl(metadata) #5
 ; Function Attrs: nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none)
 declare i64 @llvm.umin.i64(i64, i64) #6
 
+; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #7
+
 attributes #0 = { nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #1 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #2 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
@@ -239,8 +243,9 @@ attributes #3 = { cold noreturn nounwind nonlazybind uwtable "probe-stack"="inli
 attributes #4 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
 attributes #5 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
 attributes #6 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
-attributes #7 = { noreturn }
-attributes #8 = { cold noreturn nounwind }
+attributes #7 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #8 = { noreturn }
+attributes #9 = { cold noreturn nounwind }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/hyper-rs/optimized/5drhzjx8c241ue20.ll b/bench/hyper-rs/optimized/5drhzjx8c241ue20.ll
index 647de3cb607..3405c754c36 100644
--- a/bench/hyper-rs/optimized/5drhzjx8c241ue20.ll
+++ b/bench/hyper-rs/optimized/5drhzjx8c241ue20.ll
@@ -33,6 +33,8 @@ define internal void @"_ZN4core3ptr118drop_in_place$LT$alloc..boxed..Box$LT$dyn$
 6:                                                ; preds = %1
   %7 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %4) ]
   %8 = getelementptr inbounds nuw i8, ptr %4, i64 8
   %9 = load i64, ptr %8, align 8, !range !6, !invariant.load !4
   %10 = getelementptr inbounds nuw i8, ptr %4, i64 16
@@ -47,6 +49,8 @@ define internal void @"_ZN4core3ptr118drop_in_place$LT$alloc..boxed..Box$LT$dyn$
   br label %"_ZN72_$LT$alloc..boxed..Box$LT$T$C$A$GT$$u20$as$u20$core..ops..drop..Drop$GT$4drop17h952641b8fa9b7806E.exit"
 
 15:                                               ; preds = %1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %4) ]
   %16 = getelementptr inbounds nuw i8, ptr %4, i64 8
   %17 = load i64, ptr %16, align 8, !range !6, !invariant.load !4
   %18 = getelementptr inbounds nuw i8, ptr %4, i64 16
@@ -213,28 +217,27 @@ define noundef zeroext i1 @_ZN5hyper5error5Error10is_timeout17h1bdf15bba89e103aE
   br label %.lr.ph.i
 
 .lr.ph.i:                                         ; preds = %11, %.lr.ph.preheader.i
-  %.sroa.0.014.i = phi ptr [ %.sroa.0.0.i, %11 ], [ %3, %.lr.ph.preheader.i ]
-  %.sroa.4.013.i = phi ptr [ %.sroa.4.0.i, %11 ], [ %6, %.lr.ph.preheader.i ]
-  %7 = icmp ne ptr %.sroa.4.013.i, null
-  tail call void @llvm.assume(i1 %7)
+  %.sroa.0.014.i = phi ptr [ %.sroa.0.0.i, %10 ], [ %3, %.lr.ph.preheader.i ]
+  %.sroa.4.013.i = phi ptr [ %.sroa.4.0.i, %10 ], [ %6, %.lr.ph.preheader.i ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.4.013.i) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !16)
   %8 = getelementptr inbounds nuw i8, ptr %.sroa.4.013.i, i64 56
   %9 = load ptr, ptr %8, align 8, !invariant.load !4, !alias.scope !16, !noalias !9, !nonnull !4
-  %10 = tail call noundef i128 %9(ptr noundef nonnull align 1 %.sroa.0.014.i), !noalias !19
+  %10 = tail call noundef i128 %8(ptr noundef nonnull align 1 %.sroa.0.014.i), !noalias !19
   %.not11.i = icmp eq i128 %10, -3455604291313433198194752821752098272
   br i1 %.not11.i, label %_ZN5hyper5error5Error11find_source17ha0785acde139003fE.exit, label %11
 
 11:                                               ; preds = %.lr.ph.i
   %12 = getelementptr inbounds nuw i8, ptr %.sroa.4.013.i, i64 48
   %13 = load ptr, ptr %12, align 8, !invariant.load !4, !noalias !9, !nonnull !4
-  %14 = tail call { ptr, ptr } %13(ptr noundef nonnull align 1 %.sroa.0.014.i), !noalias !9
+  %14 = tail call { ptr, ptr } %12(ptr noundef nonnull align 1 %.sroa.0.014.i), !noalias !9
   %.sroa.4.0.i = extractvalue { ptr, ptr } %14, 1
   %.sroa.0.0.i = extractvalue { ptr, ptr } %14, 0
   %.not.i = icmp eq ptr %.sroa.0.0.i, null
   br i1 %.not.i, label %_ZN5hyper5error5Error11find_source17ha0785acde139003fE.exit, label %.lr.ph.i
 
 _ZN5hyper5error5Error11find_source17ha0785acde139003fE.exit: ; preds = %.lr.ph.i, %11, %1
-  %.0.i = phi i1 [ false, %1 ], [ %.not11.i, %11 ], [ %.not11.i, %.lr.ph.i ]
+  %.0.i = phi i1 [ false, %1 ], [ %.not11.i, %10 ], [ %.not11.i, %.lr.ph.i ]
   ret i1 %.0.i
 }
 
@@ -423,6 +426,7 @@ define noundef zeroext i1 @"_ZN56_$LT$hyper..error..Error$u20$as$u20$core..fmt..
 ; Function Attrs: nonlazybind uwtable
 define noundef zeroext i1 @"_ZN58_$LT$hyper..error..Error$u20$as$u20$core..fmt..Display$GT$3fmt17hc5e7a82ff744cd55E"(ptr noalias noundef readonly align 8 captures(none) dereferenceable(8) %0, ptr noalias noundef align 8 dereferenceable(64) %1) unnamed_addr #0 {
   %.val = load ptr, ptr %0, align 8, !nonnull !4, !align !5, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %3 = getelementptr inbounds nuw i8, ptr %.val, i64 16
   %4 = load i8, ptr %3, align 8, !range !8, !noundef !4
   %5 = icmp samesign ugt i8 %4, 2
diff --git a/bench/icu/optimized/fpositer.ll b/bench/icu/optimized/fpositer.ll
index b15675e060b..1af62c19e27 100644
--- a/bench/icu/optimized/fpositer.ll
+++ b/bench/icu/optimized/fpositer.ll
@@ -78,16 +78,15 @@ define void @_ZN6icu_7721FieldPositionIteratorC2ERKS0_(ptr noundef nonnull align
   call void @llvm.lifetime.start.p0(ptr nonnull %3)
   store i32 0, ptr %3, align 4, !tbaa !14
   %11 = tail call noundef ptr @_ZN6icu_777UMemorynwEm(i64 noundef 32) #8
-  %12 = icmp ne ptr %11, null
-  tail call void @llvm.assume(i1 %12)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %11) ]
   invoke void @_ZN6icu_779UVector32C1ER10UErrorCode(ptr noundef nonnull align 8 dereferenceable(32) %11, ptr noundef nonnull align 4 dereferenceable(4) %3)
-          to label %13 unwind label %25
+          to label %12 unwind label %25
 
 13:                                               ; preds = %10
   store ptr %11, ptr %4, align 8, !tbaa !6
   %14 = load ptr, ptr %8, align 8, !tbaa !6
   invoke void @_ZN6icu_779UVector326assignERKS0_R10UErrorCode(ptr noundef nonnull align 8 dereferenceable(32) %11, ptr noundef nonnull align 8 dereferenceable(32) %14, ptr noundef nonnull align 4 dereferenceable(4) %3)
-          to label %15 unwind label %27
+          to label %14 unwind label %27
 
 15:                                               ; preds = %13
   %16 = load i32, ptr %3, align 4, !tbaa !14
@@ -103,7 +102,7 @@ define void @_ZN6icu_7721FieldPositionIteratorC2ERKS0_(ptr noundef nonnull align
   %21 = load ptr, ptr %18, align 8, !tbaa !3
   %22 = getelementptr inbounds nuw i8, ptr %21, i64 8
   %23 = load ptr, ptr %22, align 8
-  call void %23(ptr noundef nonnull align 8 dereferenceable(32) %18) #8
+  call void %22(ptr noundef nonnull align 8 dereferenceable(32) %18) #8
   br label %24
 
 24:                                               ; preds = %20, %17
@@ -127,7 +126,7 @@ define void @_ZN6icu_7721FieldPositionIteratorC2ERKS0_(ptr noundef nonnull align
   br label %31
 
 30:                                               ; preds = %25, %27
-  %.pn = phi { ptr, i32 } [ %28, %27 ], [ %26, %25 ]
+  %.pn = phi { ptr, i32 } [ %28, %26 ], [ %26, %24 ]
   call void @llvm.lifetime.end.p0(ptr nonnull %3)
   call void @_ZN6icu_777UObjectD2Ev(ptr noundef nonnull align 8 dereferenceable(8) %0) #8
   resume { ptr, i32 } %.pn
diff --git a/bench/icu/optimized/rematch.ll b/bench/icu/optimized/rematch.ll
index ebef5246feb..03d3b31f4eb 100644
--- a/bench/icu/optimized/rematch.ll
+++ b/bench/icu/optimized/rematch.ll
@@ -16473,10 +16473,9 @@ define noundef nonnull align 8 dereferenceable(64) ptr @_ZNK6icu_7712RegexMatche
 19:                                               ; preds = %17, %15
   %.0 = phi i32 [ %16, %15 ], [ %18, %17 ]
   %20 = call noundef ptr @_ZN6icu_777UMemorynwEm(i64 noundef 64) #21
-  %21 = icmp ne ptr %20, null
-  call void @llvm.assume(i1 %21)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %20) ]
   invoke void @_ZN6icu_7713UnicodeStringC1Eiii(ptr noundef nonnull align 8 dereferenceable(64) %20, i32 noundef %.0, i32 noundef 0, i32 noundef 0)
-          to label %22 unwind label %28
+          to label %21 unwind label %28
 
 22:                                               ; preds = %19
   %23 = call noundef ptr @_ZN6icu_7713UnicodeString9getBufferEi(ptr noundef nonnull align 8 dereferenceable(64) %20, i32 noundef %.0)
@@ -16497,7 +16496,7 @@ define noundef nonnull align 8 dereferenceable(64) ptr @_ZNK6icu_7712RegexMatche
   resume { ptr, i32 } %29
 
 30:                                               ; preds = %22, %1
-  %31 = phi ptr [ %20, %22 ], [ %4, %1 ]
+  %31 = phi ptr [ %20, %21 ], [ %4, %1 ]
   ret ptr %31
 }
 
diff --git a/bench/jiff-rs/optimized/bc87zufzpghb0zqt1svthjsy4.ll b/bench/jiff-rs/optimized/bc87zufzpghb0zqt1svthjsy4.ll
index ff0b50df50b..1cb7393dc2c 100644
--- a/bench/jiff-rs/optimized/bc87zufzpghb0zqt1svthjsy4.ll
+++ b/bench/jiff-rs/optimized/bc87zufzpghb0zqt1svthjsy4.ll
@@ -2469,7 +2469,9 @@ _ZN4jiff3fmt8temporal7printer15DateTimePrinter10print_date17h334f2ef5618d5284E.e
   %206 = select i1 %205, i8 32, i8 0
   %.sroa.09.0 = or i8 %202, %206
   %.val = load ptr, ptr %15, align 8, !nonnull !6, !align !121, !noundef !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %.val.i = load ptr, ptr %.val, align 8, !nonnull !6, !align !121, !noundef !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %9), !noalias !122
   store i32 0, ptr %9, align 4, !noalias !122
   %207 = icmp sgt i8 %202, -1
@@ -3313,6 +3315,7 @@ _ZN4jiff3fmt8temporal7printer15DateTimePrinter10print_date17h4e3d6d1218f1fff7E.e
   %207 = select i1 %206, i8 32, i8 0
   %.sroa.09.0 = or i8 %203, %207
   %.val = load ptr, ptr %16, align 8, !nonnull !6, !align !121, !noundef !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %10), !noalias !207
   store i32 0, ptr %10, align 4, !noalias !207
   %208 = icmp sgt i8 %203, -1
@@ -3796,6 +3799,7 @@ define hidden { i64, ptr } @_ZN4jiff3fmt8temporal7printer15DateTimePrinter14prin
   %27 = select i1 %26, i8 32, i8 0
   %.sroa.09.0 = or i8 %23, %27
   %.val = load ptr, ptr %12, align 8, !nonnull !6, !align !121, !noundef !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %10), !noalias !255
   store i32 0, ptr %10, align 4, !noalias !255
   %28 = icmp sgt i8 %23, -1
@@ -9425,6 +9429,7 @@ _ZN4jiff3fmt4util7Decimal3new17hfa803fb8c2dfdc3fE.exit: ; preds = %71, %.prehead
 100:                                              ; preds = %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h3d0deea6cfc1c6d6E.exit"
   %101 = call noundef i32 @_ZN4jiff3fmt8temporal7printer11SpanPrinter5label17hf5ca1f9add08c92dE(ptr noalias noundef nonnull readonly align 1 dereferenceable(1) %0, i32 noundef 89)
   %.val = load ptr, ptr %17, align 8, !nonnull !6, !align !121, !noundef !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %7), !noalias !695
   store i32 0, ptr %7, align 4, !noalias !695
   %102 = icmp samesign ult i32 %101, 128
@@ -9624,6 +9629,7 @@ _ZN4jiff3fmt4util7Decimal3new17hfa803fb8c2dfdc3fE.exit228: ; preds = %173, %.pre
 201:                                              ; preds = %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h3d0deea6cfc1c6d6E.exit218"
   %202 = call noundef i32 @_ZN4jiff3fmt8temporal7printer11SpanPrinter5label17hf5ca1f9add08c92dE(ptr noalias noundef nonnull readonly align 1 dereferenceable(1) %0, i32 noundef 77)
   %.val253 = load ptr, ptr %17, align 8, !nonnull !6, !align !121, !noundef !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val253) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %6), !noalias !710
   store i32 0, ptr %6, align 4, !noalias !710
   %203 = icmp samesign ult i32 %202, 128
@@ -9823,6 +9829,7 @@ _ZN4jiff3fmt4util7Decimal3new17hfa803fb8c2dfdc3fE.exit232: ; preds = %274, %.pre
 302:                                              ; preds = %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h3d0deea6cfc1c6d6E.exit219"
   %303 = call noundef i32 @_ZN4jiff3fmt8temporal7printer11SpanPrinter5label17hf5ca1f9add08c92dE(ptr noalias noundef nonnull readonly align 1 dereferenceable(1) %0, i32 noundef 87)
   %.val254 = load ptr, ptr %17, align 8, !nonnull !6, !align !121, !noundef !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val254) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %5), !noalias !725
   store i32 0, ptr %5, align 4, !noalias !725
   %304 = icmp samesign ult i32 %303, 128
@@ -10022,6 +10029,7 @@ _ZN4jiff3fmt4util7Decimal3new17hfa803fb8c2dfdc3fE.exit236: ; preds = %375, %.pre
 403:                                              ; preds = %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h3d0deea6cfc1c6d6E.exit220"
   %404 = call noundef i32 @_ZN4jiff3fmt8temporal7printer11SpanPrinter5label17hf5ca1f9add08c92dE(ptr noalias noundef nonnull readonly align 1 dereferenceable(1) %0, i32 noundef 68)
   %.val255 = load ptr, ptr %17, align 8, !nonnull !6, !align !121, !noundef !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val255) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !740
   store i32 0, ptr %4, align 4, !noalias !740
   %405 = icmp samesign ult i32 %404, 128
@@ -13578,6 +13586,7 @@ _ZN4jiff3fmt4util7Decimal3new17hfa803fb8c2dfdc3fE.exit115: ; preds = %125, %.pre
 151:                                              ; preds = %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h3d0deea6cfc1c6d6E.exit"
   %152 = call noundef i32 @_ZN4jiff3fmt8temporal7printer11SpanPrinter5label17hf5ca1f9add08c92dE(ptr noalias noundef nonnull readonly align 1 dereferenceable(1) %0, i32 noundef 72)
   %.val = load ptr, ptr %12, align 8, !nonnull !6, !align !121, !noundef !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %6), !noalias !1024
   store i32 0, ptr %6, align 4, !noalias !1024
   %153 = icmp samesign ult i32 %152, 128
@@ -13662,6 +13671,7 @@ _ZN4jiff3fmt4util7Decimal3new17hfa803fb8c2dfdc3fE.exit115: ; preds = %125, %.pre
 196:                                              ; preds = %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h3d0deea6cfc1c6d6E.exit109"
   %197 = call noundef i32 @_ZN4jiff3fmt8temporal7printer11SpanPrinter5label17hf5ca1f9add08c92dE(ptr noalias noundef nonnull readonly align 1 dereferenceable(1) %0, i32 noundef 77)
   %.val124 = load ptr, ptr %12, align 8, !nonnull !6, !align !121, !noundef !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val124) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %5), !noalias !1030
   store i32 0, ptr %5, align 4, !noalias !1030
   %198 = icmp samesign ult i32 %197, 128
@@ -13848,6 +13858,7 @@ _ZN4jiff3fmt4util7Decimal3new17hfa803fb8c2dfdc3fE.exit119: ; preds = %268, %.pre
 290:                                              ; preds = %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17h3d0deea6cfc1c6d6E.exit110"
   %291 = call noundef i32 @_ZN4jiff3fmt8temporal7printer11SpanPrinter5label17hf5ca1f9add08c92dE(ptr noalias noundef nonnull readonly align 1 dereferenceable(1) %0, i32 noundef 83)
   %.val125 = load ptr, ptr %12, align 8, !nonnull !6, !align !121, !noundef !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val125) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !1045
   store i32 0, ptr %4, align 4, !noalias !1045
   %292 = icmp samesign ult i32 %291, 128
@@ -14172,8 +14183,7 @@ _ZN4core4char7methods15encode_utf8_raw17h47e0c198e2a85c4bE.exit: ; preds = %8, %
 ; Function Attrs: inlinehint nonlazybind uwtable
 define internal fastcc void @"_ZN50_$LT$$RF$mut$u20$W$u20$as$u20$jiff..fmt..Write$GT$10write_char17hc8773bada09487b2E"(ptr %.0.val, i32 noundef range(i32 0, 1114112) %0) unnamed_addr #0 {
   %2 = alloca [4 x i8], align 4
-  %3 = icmp ne ptr %.0.val, null
-  tail call void @llvm.assume(i1 %3)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.0.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !1067
   store i32 0, ptr %2, align 4, !noalias !1067
   %4 = icmp samesign ult i32 %0, 128
@@ -14245,7 +14255,7 @@ define internal fastcc void @"_ZN50_$LT$$RF$mut$u20$W$u20$as$u20$jiff..fmt..Writ
   br label %_ZN4jiff3fmt5Write10write_char17h6e26dc6cb2678f54E.exit
 
 _ZN4jiff3fmt5Write10write_char17h6e26dc6cb2678f54E.exit: ; preds = %7, %11, %18, %33
-  %.sroa.0.05.i.sroa.phi.i = phi ptr [ %.sroa.0.05.i.sroa.gep.i, %7 ], [ %.sroa.0.05.i.sroa.gep1.i, %11 ], [ %.sroa.0.05.i.sroa.gep2.i, %18 ], [ %.sroa.0.05.i.sroa.gep3.i, %33 ]
+  %.sroa.0.05.i.sroa.phi.i = phi ptr [ %.sroa.0.05.i.sroa.gep.i, %6 ], [ %.sroa.0.05.i.sroa.gep1.i, %10 ], [ %.sroa.0.05.i.sroa.gep2.i, %17 ], [ %.sroa.0.05.i.sroa.gep3.i, %32 ]
   call void @"_ZN132_$LT$alloc..vec..Vec$LT$T$C$A$GT$$u20$as$u20$alloc..vec..spec_extend..SpecExtend$LT$$RF$T$C$core..slice..iter..Iter$LT$T$GT$$GT$$GT$11spec_extend17he8c9407ef5b33ecaE"(ptr noalias noundef nonnull align 8 dereferenceable(24) %.0.val, ptr noundef nonnull readonly align 1 %2, ptr noundef nonnull readonly %.sroa.0.05.i.sroa.phi.i, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.defb23c543a0d58eda124284528ab762.11)
   call void @llvm.lifetime.end.p0(ptr nonnull %2), !noalias !1067
   ret void
diff --git a/bench/jiff-rs/optimized/d5ptug8pk58j4ioidoz8wi1r8.ll b/bench/jiff-rs/optimized/d5ptug8pk58j4ioidoz8wi1r8.ll
index 173e1665bc4..a2aef4a9522 100644
--- a/bench/jiff-rs/optimized/d5ptug8pk58j4ioidoz8wi1r8.ll
+++ b/bench/jiff-rs/optimized/d5ptug8pk58j4ioidoz8wi1r8.ll
@@ -185,10 +185,9 @@ define hidden { ptr, ptr } @"_ZN103_$LT$alloc..vec..into_iter..IntoIter$LT$T$C$A
 22:                                               ; preds = %14
   %23 = extractvalue { ptr, i64 } %19, 0
   %24 = extractvalue { ptr, i64 } %19, 1
-  %25 = icmp ne ptr %23, null
-  call void @llvm.assume(i1 %25)
-  %26 = getelementptr inbounds nuw i8, ptr %23, i64 16
-  %27 = invoke noundef i64 @_ZN5alloc4sync11data_offset17hfe7aaf128a4a50a1E(ptr noundef nonnull %26, i64 noundef %24)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %23) ]
+  %25 = getelementptr inbounds nuw i8, ptr %23, i64 16
+  %26 = invoke noundef i64 @_ZN5alloc4sync11data_offset17hfe7aaf128a4a50a1E(ptr noundef nonnull %25, i64 noundef %24)
           to label %"_ZN96_$LT$alloc..sync..Arc$LT$str$GT$$u20$as$u20$core..convert..From$LT$alloc..string..String$GT$$GT$4from17h2d8af5a8cb08cd1cE.exit.i.i" unwind label %20, !noalias !20
 
 28:                                               ; preds = %20
@@ -210,9 +209,9 @@ define hidden { ptr, ptr } @"_ZN103_$LT$alloc..vec..into_iter..IntoIter$LT$T$C$A
   resume { ptr, i32 } %eh.lpad-body.i
 
 .body.i:                                          ; preds = %30, %20
-  %eh.lpad-body.i = phi { ptr, i32 } [ %31, %30 ], [ %21, %20 ]
+  %eh.lpad-body.i = phi { ptr, i32 } [ %31, %29 ], [ %21, %20 ]
   invoke fastcc void @"_ZN4core3ptr94drop_in_place$LT$alloc..vec..in_place_drop..InPlaceDrop$LT$alloc..sync..Arc$LT$str$GT$$GT$$GT$17he6145e324304d180E"(ptr noalias noundef align 8 dereferenceable(16) %7) #20
-          to label %32 unwind label %33, !noalias !11
+          to label %31 unwind label %33, !noalias !11
 
 33:                                               ; preds = %.body.i
   %34 = landingpad { ptr, i32 }
@@ -221,8 +220,8 @@ define hidden { ptr, ptr } @"_ZN103_$LT$alloc..vec..into_iter..IntoIter$LT$T$C$A
   unreachable
 
 "_ZN4core4iter8adapters3map12map_try_fold28_$u7b$$u7b$closure$u7d$$u7d$17h1430871834013720E.exit": ; preds = %"_ZN96_$LT$alloc..sync..Arc$LT$str$GT$$u20$as$u20$core..convert..From$LT$alloc..string..String$GT$$GT$4from17h2d8af5a8cb08cd1cE.exit.i.i"
-  %35 = sub nsw i64 0, %27
-  %36 = getelementptr inbounds i8, ptr %26, i64 %35
+  %35 = sub nsw i64 0, %26
+  %36 = getelementptr inbounds i8, ptr %25, i64 %35
   call void @llvm.lifetime.end.p0(ptr nonnull %6), !noalias !11
   store ptr %36, ptr %.sroa.4.014, align 8, !noalias !11
   %37 = getelementptr inbounds nuw i8, ptr %.sroa.4.014, i64 8
@@ -415,6 +414,8 @@ define hidden void @"_ZN5alloc3vec9into_iter21IntoIter$LT$T$C$A$GT$32forget_allo
   %4 = load ptr, ptr %3, align 8, !nonnull !3, !noundef !3
   %5 = getelementptr inbounds nuw i8, ptr %0, i64 24
   %.val1 = load ptr, ptr %5, align 8, !nonnull !3, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %4) ]
   %6 = ptrtoint ptr %.val1 to i64
   %7 = ptrtoint ptr %4 to i64
   %8 = sub nuw i64 %6, %7
@@ -2081,9 +2082,11 @@ _ZN4core3fmt9Formatter9write_fmt17h84cdd179c532562aE.exit: ; preds = %22
   store ptr %12, ptr %13, align 8
   %.sroa.45.0..sroa_idx = getelementptr inbounds nuw i8, ptr %13, i64 8
   store ptr @"_ZN4core3fmt3num3imp52_$LT$impl$u20$core..fmt..Display$u20$for$u20$i64$GT$3fmt17h40b427f40fae239aE", ptr %.sroa.45.0..sroa_idx, align 8
-  %.val23 = load ptr, ptr %1, align 8, !nonnull !3, !noundef !3
+  %.val23 = load ptr, ptr %1, align 8
   %30 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val24 = load ptr, ptr %30, align 8, !nonnull !3, !noundef !3
+  %.val24 = load ptr, ptr %30, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val23) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val24) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %5), !noalias !153
   store ptr @anon.f4f476f25df25ce4cf7c271eb4237b82.50, ptr %5, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %5, i64 8
@@ -2112,9 +2115,11 @@ _ZN4core3fmt9Formatter9write_fmt17h84cdd179c532562aE.exit29: ; preds = %32
   store ptr %10, ptr %11, align 8
   %.sroa.49.0..sroa_idx = getelementptr inbounds nuw i8, ptr %11, i64 8
   store ptr @"_ZN4core3fmt3num3imp52_$LT$impl$u20$core..fmt..Display$u20$for$u20$i32$GT$3fmt17hd42deda1b830d1a7E", ptr %.sroa.49.0..sroa_idx, align 8
-  %.val21 = load ptr, ptr %1, align 8, !nonnull !3, !noundef !3
+  %.val21 = load ptr, ptr %1, align 8
   %35 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val22 = load ptr, ptr %35, align 8, !nonnull !3, !noundef !3
+  %.val22 = load ptr, ptr %35, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val21) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val22) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !156
   store ptr @anon.f4f476f25df25ce4cf7c271eb4237b82.52, ptr %4, align 8
   %.sroa.536.0..sroa_idx = getelementptr inbounds nuw i8, ptr %4, i64 8
@@ -2145,9 +2150,11 @@ _ZN4core3fmt9Formatter9write_fmt17h84cdd179c532562aE.exit34: ; preds = %32
   store ptr %7, ptr %37, align 8
   %.sroa.418.0..sroa_idx = getelementptr inbounds nuw i8, ptr %9, i64 24
   store ptr @"_ZN4core3fmt3num3imp52_$LT$impl$u20$core..fmt..Display$u20$for$u20$u32$GT$3fmt17h192ecd7f68372d7fE", ptr %.sroa.418.0..sroa_idx, align 8
-  %.val = load ptr, ptr %1, align 8, !nonnull !3, !noundef !3
+  %.val = load ptr, ptr %1, align 8
   %38 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val20 = load ptr, ptr %38, align 8, !nonnull !3, !noundef !3
+  %.val20 = load ptr, ptr %38, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val20) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !159
   store ptr @anon.f4f476f25df25ce4cf7c271eb4237b82.54, ptr %3, align 8
   %.sroa.542.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 8
diff --git a/bench/libigl/optimized/point_areas.ll b/bench/libigl/optimized/point_areas.ll
index a9cdbcac1d4..7609f730f5a 100644
--- a/bench/libigl/optimized/point_areas.ll
+++ b/bench/libigl/optimized/point_areas.ll
@@ -34432,8 +34432,7 @@ define linkonce_odr dso_local ptr @_ZN4CGAL15Triangulation_2INS_5EpickENS_30Tria
   br i1 %226, label %._crit_edge, label %.lr.ph166, !llvm.loop !1216
 
 ._crit_edge:                                      ; preds = %221, %.preheader
-  %227 = icmp ne ptr %182, null
-  call void @llvm.assume(i1 %227)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %182) ]
   %.sroa.0.0.copyload.i.i.i.i112 = load ptr, ptr %182, align 8, !tbaa !188, !nonnull !244, !noundef !244
   %228 = getelementptr inbounds nuw i8, ptr %.sroa.0.0.copyload.i.i.i.i112, i64 16
   %229 = load ptr, ptr %228, align 8, !tbaa !179
@@ -34450,9 +34449,9 @@ define linkonce_odr dso_local ptr @_ZN4CGAL15Triangulation_2INS_5EpickENS_30Tria
   br i1 %or.cond.i.i167, label %_ZNSt7__cxx1110_List_baseIN4CGAL8internal11CC_iteratorINS1_17Compact_containerINS1_28Triangulation_ds_face_base_2INS1_30Triangulation_data_structure_2INS1_37Triangulation_vertex_base_with_info_2IjNS1_5EpickENS1_27Triangulation_vertex_base_2IS8_NS1_30Triangulation_ds_vertex_base_2IvEEEEEENS5_IvEEEEEENS1_7DefaultESH_SH_EELb0EEESaISJ_EED2Ev.exit, label %_ZNK4CGAL15Triangulation_2INS_5EpickENS_30Triangulation_data_structure_2INS_37Triangulation_vertex_base_with_info_2IjS1_NS_27Triangulation_vertex_base_2IS1_NS_30Triangulation_ds_vertex_base_2IvEEEEEENS_28Triangulation_ds_face_base_2IvEEEEE11is_infiniteENS_8internal11CC_iteratorINS_17Compact_containerINS9_ISB_EENS_7DefaultESH_SH_EELb0EEE.exit
 
 _ZNK4CGAL15Triangulation_2INS_5EpickENS_30Triangulation_data_structure_2INS_37Triangulation_vertex_base_with_info_2IjS1_NS_27Triangulation_vertex_base_2IS1_NS_30Triangulation_ds_vertex_base_2IvEEEEEENS_28Triangulation_ds_face_base_2IvEEEEE11is_infiniteENS_8internal11CC_iteratorINS_17Compact_containerINS9_ISB_EENS_7DefaultESH_SH_EELb0EEE.exit: ; preds = %._crit_edge, %240
-  %235 = phi ptr [ %253, %240 ], [ %233, %._crit_edge ]
-  %236 = phi ptr [ %250, %240 ], [ %230, %._crit_edge ]
-  %.sroa.9.2168 = phi ptr [ %.sroa.0.0.copyload.i.i.i118, %240 ], [ %spec.select4.i.i107, %._crit_edge ]
+  %235 = phi ptr [ %253, %239 ], [ %233, %._crit_edge ]
+  %236 = phi ptr [ %250, %239 ], [ %230, %._crit_edge ]
+  %.sroa.9.2168 = phi ptr [ %.sroa.0.0.copyload.i.i.i118, %239 ], [ %spec.select4.i.i107, %._crit_edge ]
   %237 = getelementptr inbounds nuw i8, ptr %.sroa.9.2168, i64 16
   %238 = load ptr, ptr %237, align 8, !tbaa !179
   %239 = icmp eq ptr %238, %.sroa.0.0.copyload.i.i
@@ -34478,7 +34477,7 @@ _ZNK4CGAL15Triangulation_2INS_5EpickENS_30Triangulation_data_structure_2INS_37Tr
   br i1 %or.cond.i.i, label %_ZNSt7__cxx1110_List_baseIN4CGAL8internal11CC_iteratorINS1_17Compact_containerINS1_28Triangulation_ds_face_base_2INS1_30Triangulation_data_structure_2INS1_37Triangulation_vertex_base_with_info_2IjNS1_5EpickENS1_27Triangulation_vertex_base_2IS8_NS1_30Triangulation_ds_vertex_base_2IvEEEEEENS5_IvEEEEEENS1_7DefaultESH_SH_EELb0EEESaISJ_EED2Ev.exit, label %_ZNK4CGAL15Triangulation_2INS_5EpickENS_30Triangulation_data_structure_2INS_37Triangulation_vertex_base_with_info_2IjS1_NS_27Triangulation_vertex_base_2IS1_NS_30Triangulation_ds_vertex_base_2IvEEEEEENS_28Triangulation_ds_face_base_2IvEEEEE11is_infiniteENS_8internal11CC_iteratorINS_17Compact_containerINS9_ISB_EENS_7DefaultESH_SH_EELb0EEE.exit
 
 _ZNSt7__cxx1110_List_baseIN4CGAL8internal11CC_iteratorINS1_17Compact_containerINS1_28Triangulation_ds_face_base_2INS1_30Triangulation_data_structure_2INS1_37Triangulation_vertex_base_with_info_2IjNS1_5EpickENS1_27Triangulation_vertex_base_2IS8_NS1_30Triangulation_ds_vertex_base_2IvEEEEEENS5_IvEEEEEENS1_7DefaultESH_SH_EELb0EEESaISJ_EED2Ev.exit: ; preds = %_ZNK4CGAL15Triangulation_2INS_5EpickENS_30Triangulation_data_structure_2INS_37Triangulation_vertex_base_with_info_2IjS1_NS_27Triangulation_vertex_base_2IS1_NS_30Triangulation_ds_vertex_base_2IvEEEEEENS_28Triangulation_ds_face_base_2IvEEEEE11is_infiniteENS_8internal11CC_iteratorINS_17Compact_containerINS9_ISB_EENS_7DefaultESH_SH_EELb0EEE.exit, %240, %._crit_edge
-  %.sroa.9.2.lcssa = phi ptr [ %spec.select4.i.i107, %._crit_edge ], [ %.sroa.0.0.copyload.i.i.i118, %240 ], [ %.sroa.9.2168, %_ZNK4CGAL15Triangulation_2INS_5EpickENS_30Triangulation_data_structure_2INS_37Triangulation_vertex_base_with_info_2IjS1_NS_27Triangulation_vertex_base_2IS1_NS_30Triangulation_ds_vertex_base_2IvEEEEEENS_28Triangulation_ds_face_base_2IvEEEEE11is_infiniteENS_8internal11CC_iteratorINS_17Compact_containerINS9_ISB_EENS_7DefaultESH_SH_EELb0EEE.exit ]
+  %.sroa.9.2.lcssa = phi ptr [ %spec.select4.i.i107, %._crit_edge ], [ %.sroa.0.0.copyload.i.i.i118, %239 ], [ %.sroa.9.2168, %_ZNK4CGAL15Triangulation_2INS_5EpickENS_30Triangulation_data_structure_2INS_37Triangulation_vertex_base_with_info_2IjS1_NS_27Triangulation_vertex_base_2IS1_NS_30Triangulation_ds_vertex_base_2IvEEEEEENS_28Triangulation_ds_face_base_2IvEEEEE11is_infiniteENS_8internal11CC_iteratorINS_17Compact_containerINS9_ISB_EENS_7DefaultESH_SH_EELb0EEE.exit ]
   store ptr %.sroa.9.2.lcssa, ptr %.sroa.0.0.copyload.i.i, align 8, !tbaa !188
   call void @llvm.lifetime.end.p0(ptr nonnull %7)
   %255 = load ptr, ptr %6, align 8, !tbaa !938
@@ -34503,7 +34502,7 @@ _ZNSt7__cxx1110_List_baseIN4CGAL8internal11CC_iteratorINS1_17Compact_containerIN
   br i1 %.not8.i.i128, label %_ZNSt7__cxx1110_List_baseIN4CGAL8internal11CC_iteratorINS1_17Compact_containerINS1_28Triangulation_ds_face_base_2INS1_30Triangulation_data_structure_2INS1_37Triangulation_vertex_base_with_info_2IjNS1_5EpickENS1_27Triangulation_vertex_base_2IS8_NS1_30Triangulation_ds_vertex_base_2IvEEEEEENS5_IvEEEEEENS1_7DefaultESH_SH_EELb0EEESaISJ_EED2Ev.exit132, label %.lr.ph.i.i129
 
 .lr.ph.i.i129:                                    ; preds = %257, %.lr.ph.i.i129
-  %.09.i.i130 = phi ptr [ %259, %.lr.ph.i.i129 ], [ %258, %257 ]
+  %.09.i.i130 = phi ptr [ %259, %.lr.ph.i.i129 ], [ %258, %256 ]
   %259 = load ptr, ptr %.09.i.i130, align 8, !tbaa !938
   call void @_ZdlPvm(ptr noundef nonnull %.09.i.i130, i64 noundef 24) #42
   %.not.i.i131 = icmp eq ptr %259, %7
diff --git a/bench/libquic/optimized/x509name.ll b/bench/libquic/optimized/x509name.ll
index a418cb8c4c3..33926f9c6d1 100644
--- a/bench/libquic/optimized/x509name.ll
+++ b/bench/libquic/optimized/x509name.ll
@@ -62,27 +62,26 @@ X509_NAME_get_entry.exit:                         ; preds = %X509_NAME_get_index
   tail call void @llvm.assume(i1 %.not.i)
   %21 = load ptr, ptr %0, align 8, !tbaa !6
   %22 = tail call ptr @sk_value(ptr noundef %21, i64 noundef %20) #7
-  %23 = icmp ne ptr %22, null
-  tail call void @llvm.assume(i1 %23)
-  %24 = getelementptr inbounds nuw i8, ptr %22, i64 8
-  %25 = load ptr, ptr %24, align 8, !tbaa !21
-  %26 = load i32, ptr %25, align 8, !tbaa !22
-  %27 = icmp eq ptr %2, null
-  br i1 %27, label %X509_NAME_get_index_by_OBJ.exit.thread, label %28
-
-28:                                               ; preds = %X509_NAME_get_entry.exit
-  %29 = add nsw i32 %3, -1
-  %30 = tail call i32 @llvm.smin.i32(i32 %26, i32 %29)
-  %31 = getelementptr inbounds nuw i8, ptr %25, i64 8
-  %32 = load ptr, ptr %31, align 8, !tbaa !25
-  %33 = sext i32 %30 to i64
-  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %2, ptr align 1 %32, i64 %33, i1 false)
-  %34 = getelementptr inbounds i8, ptr %2, i64 %33
-  store i8 0, ptr %34, align 1, !tbaa !26
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %22) ]
+  %23 = getelementptr inbounds nuw i8, ptr %22, i64 8
+  %24 = load ptr, ptr %23, align 8, !tbaa !21
+  %25 = load i32, ptr %24, align 8, !tbaa !22
+  %26 = icmp eq ptr %2, null
+  br i1 %26, label %X509_NAME_get_index_by_OBJ.exit.thread, label %27
+
+27:                                               ; preds = %X509_NAME_get_entry.exit
+  %28 = add nsw i32 %3, -1
+  %29 = tail call i32 @llvm.smin.i32(i32 %25, i32 %28)
+  %30 = getelementptr inbounds nuw i8, ptr %24, i64 8
+  %31 = load ptr, ptr %30, align 8, !tbaa !25
+  %32 = sext i32 %29 to i64
+  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %2, ptr align 1 %31, i64 %32, i1 false)
+  %33 = getelementptr inbounds i8, ptr %2, i64 %32
+  store i8 0, ptr %33, align 1, !tbaa !26
   br label %X509_NAME_get_index_by_OBJ.exit.thread
 
-X509_NAME_get_index_by_OBJ.exit.thread:           ; preds = %11, %4, %X509_NAME_get_entry.exit, %X509_NAME_get_index_by_OBJ.exit, %28
-  %.0 = phi i32 [ %30, %28 ], [ %26, %X509_NAME_get_entry.exit ], [ -1, %X509_NAME_get_index_by_OBJ.exit ], [ -1, %4 ], [ -1, %11 ]
+X509_NAME_get_index_by_OBJ.exit.thread:           ; preds = %11, %4, %X509_NAME_get_entry.exit, %X509_NAME_get_index_by_OBJ.exit, %27
+  %.0 = phi i32 [ %29, %27 ], [ %25, %X509_NAME_get_entry.exit ], [ -1, %X509_NAME_get_index_by_OBJ.exit ], [ -1, %4 ], [ -1, %11 ]
   ret i32 %.0
 }
 
diff --git a/bench/libzmq/optimized/socket_base.ll b/bench/libzmq/optimized/socket_base.ll
index 0bc98bf9a21..f22e1bebc57 100644
--- a/bench/libzmq/optimized/socket_base.ll
+++ b/bench/libzmq/optimized/socket_base.ll
@@ -9691,28 +9691,27 @@ _ZNSt8multimapINSt7__cxx1112basic_stringIcSt11char_traitsIcESaIcEEEPN3zmq6pipe_t
 
 _ZN3zmq13socket_base_t9inprocs_t10erase_pipeEPKNS_6pipe_tE.exit: ; preds = %21, %2, %_ZNSt8multimapINSt7__cxx1112basic_stringIcSt11char_traitsIcESaIcEEEPN3zmq6pipe_tESt4lessIS5_ESaISt4pairIKS5_S8_EEE5eraseB5cxx11ESt17_Rb_tree_iteratorISD_E.exit.i
   %23 = getelementptr inbounds nuw i8, ptr %0, i64 1640
-  %24 = icmp ne ptr %1, null
-  tail call void @llvm.assume(i1 %24)
-  %25 = load ptr, ptr %23, align 8, !tbaa !218
-  %26 = getelementptr inbounds nuw i8, ptr %0, i64 1648
-  %27 = load ptr, ptr %26, align 8, !tbaa !218
-  %28 = icmp eq ptr %25, %27
-  br i1 %28, label %_ZN3zmq7array_tINS_6pipe_tELi3EE5eraseEPS1_.exit, label %29
-
-29:                                               ; preds = %_ZN3zmq13socket_base_t9inprocs_t10erase_pipeEPKNS_6pipe_tE.exit
-  %30 = getelementptr inbounds nuw i8, ptr %1, i64 64
-  %31 = load i32, ptr %30, align 8, !tbaa !134
-  %32 = sext i32 %31 to i64
-  %33 = getelementptr inbounds i8, ptr %27, i64 -8
-  %34 = load ptr, ptr %33, align 8, !tbaa !3, !nonnull !98, !noundef !98
-  %35 = getelementptr inbounds nuw i8, ptr %34, i64 64
-  store i32 %31, ptr %35, align 8, !tbaa !134
-  %36 = getelementptr inbounds nuw ptr, ptr %25, i64 %32
-  store ptr %34, ptr %36, align 8, !tbaa !3
-  store ptr %33, ptr %26, align 8, !tbaa !133
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
+  %24 = load ptr, ptr %23, align 8, !tbaa !218
+  %25 = getelementptr inbounds nuw i8, ptr %0, i64 1648
+  %26 = load ptr, ptr %25, align 8, !tbaa !218
+  %27 = icmp eq ptr %24, %26
+  br i1 %27, label %_ZN3zmq7array_tINS_6pipe_tELi3EE5eraseEPS1_.exit, label %28
+
+28:                                               ; preds = %_ZN3zmq13socket_base_t9inprocs_t10erase_pipeEPKNS_6pipe_tE.exit
+  %29 = getelementptr inbounds nuw i8, ptr %1, i64 64
+  %30 = load i32, ptr %29, align 8, !tbaa !134
+  %31 = sext i32 %30 to i64
+  %32 = getelementptr inbounds i8, ptr %26, i64 -8
+  %33 = load ptr, ptr %32, align 8, !tbaa !3, !nonnull !98, !noundef !98
+  %34 = getelementptr inbounds nuw i8, ptr %33, i64 64
+  store i32 %30, ptr %34, align 8, !tbaa !134
+  %35 = getelementptr inbounds nuw ptr, ptr %24, i64 %31
+  store ptr %33, ptr %35, align 8, !tbaa !3
+  store ptr %32, ptr %25, align 8, !tbaa !133
   br label %_ZN3zmq7array_tINS_6pipe_tELi3EE5eraseEPS1_.exit
 
-_ZN3zmq7array_tINS_6pipe_tELi3EE5eraseEPS1_.exit: ; preds = %_ZN3zmq13socket_base_t9inprocs_t10erase_pipeEPKNS_6pipe_tE.exit, %29
+_ZN3zmq7array_tINS_6pipe_tELi3EE5eraseEPS1_.exit: ; preds = %_ZN3zmq13socket_base_t9inprocs_t10erase_pipeEPKNS_6pipe_tE.exit, %28
   %37 = tail call noundef nonnull align 8 dereferenceable(68) ptr @_ZNK3zmq6pipe_t17get_endpoint_pairEv(ptr noundef nonnull align 8 dereferenceable(328) %1)
   %38 = getelementptr inbounds nuw i8, ptr %37, i64 64
   %39 = load i32, ptr %38, align 8, !tbaa !119
@@ -9733,7 +9732,7 @@ _ZN3zmq7array_tINS_6pipe_tELi3EE5eraseEPS1_.exit: ; preds = %_ZN3zmq13socket_bas
   br i1 %.not14, label %.loopexit, label %.lr.ph
 
 .lr.ph:                                           ; preds = %45, %55
-  %.sroa.0.015 = phi ptr [ %56, %55 ], [ %48, %45 ]
+  %.sroa.0.015 = phi ptr [ %56, %54 ], [ %48, %44 ]
   %50 = getelementptr inbounds nuw i8, ptr %.sroa.0.015, i64 72
   %51 = load ptr, ptr %50, align 8, !tbaa !202
   %52 = icmp eq ptr %51, %1
diff --git a/bench/log-rs/optimized/2fembjqwp89ywpt5.ll b/bench/log-rs/optimized/2fembjqwp89ywpt5.ll
index 334a1276d55..c0140cb5b50 100644
--- a/bench/log-rs/optimized/2fembjqwp89ywpt5.ll
+++ b/bench/log-rs/optimized/2fembjqwp89ywpt5.ll
@@ -101,6 +101,7 @@ define noundef range(i64 0, 6) i64 @"_ZN57_$LT$log..Level$u20$as$u20$core..str..
   %3 = alloca { i64, { i64, i64 } }, align 8
   %4 = alloca { ptr, ptr }, align 8
   %5 = alloca { ptr, ptr }, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   %6 = getelementptr inbounds nuw i8, ptr %5, i64 8
   %7 = getelementptr inbounds nuw i8, ptr %4, i64 8
   %8 = getelementptr inbounds i8, ptr %0, i64 %1
@@ -111,13 +112,14 @@ define noundef range(i64 0, 6) i64 @"_ZN57_$LT$log..Level$u20$as$u20$core..str..
   %.idx = phi i64 [ 0, %.lr.ph.i ], [ %.add, %.loopexit.i ]
   %.ptr = getelementptr inbounds nuw i8, ptr @_ZN3log15LOG_LEVEL_NAMES17h19681b37bc026262E, i64 %.idx
   %.add = add nuw nsw i64 %.idx, 16
+  %.val8.i = load ptr, ptr %.ptr, align 8, !noalias !4, !nonnull !7, !align !8, !noundef !7
   %10 = getelementptr i8, ptr %.ptr, i64 8
   %.val9.i = load i64, ptr %10, align 8, !noalias !4, !noundef !7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val8.i) ]
   %11 = icmp eq i64 %.val9.i, %1
   br i1 %11, label %12, label %.loopexit.i
 
 12:                                               ; preds = %9
-  %.val8.i = load ptr, ptr %.ptr, align 8, !noalias !4, !nonnull !7, !align !8, !noundef !7
   %13 = getelementptr inbounds i8, ptr %.val8.i, i64 %1
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !9
   call void @llvm.lifetime.start.p0(ptr nonnull %5), !noalias !9
@@ -147,8 +149,11 @@ define noundef range(i64 0, 6) i64 @"_ZN57_$LT$log..Level$u20$as$u20$core..str..
 
 21:                                               ; preds = %19
   %22 = add i64 %20, 1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %17) ]
   %23 = getelementptr inbounds i8, ptr %17, i64 %20
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %18) ]
   %24 = getelementptr inbounds i8, ptr %18, i64 %20
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %24) ]
   %.fca.0.extract.val.i.i.i.i = load i8, ptr %23, align 1, !noalias !28, !noundef !7
   %.fca.1.extract.val.i.i.i.i = load i8, ptr %24, align 1, !noalias !28, !noundef !7
   %25 = add i8 %.fca.0.extract.val.i.i.i.i, -65
@@ -226,6 +231,7 @@ define noundef range(i64 0, 7) i64 @"_ZN63_$LT$log..LevelFilter$u20$as$u20$core.
   %3 = alloca { i64, { i64, i64 } }, align 8
   %4 = alloca { ptr, ptr }, align 8
   %5 = alloca { ptr, ptr }, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   %6 = getelementptr inbounds nuw i8, ptr %5, i64 8
   %7 = getelementptr inbounds nuw i8, ptr %4, i64 8
   %8 = getelementptr inbounds i8, ptr %0, i64 %1
@@ -236,13 +242,14 @@ define noundef range(i64 0, 7) i64 @"_ZN63_$LT$log..LevelFilter$u20$as$u20$core.
   %.idx = phi i64 [ 0, %.lr.ph.i ], [ %.add, %.loopexit.i ]
   %.ptr = getelementptr inbounds nuw i8, ptr @_ZN3log15LOG_LEVEL_NAMES17h19681b37bc026262E, i64 %.idx
   %.add = add nuw nsw i64 %.idx, 16
+  %.val8.i = load ptr, ptr %.ptr, align 8, !noalias !35, !nonnull !7, !align !8, !noundef !7
   %10 = getelementptr i8, ptr %.ptr, i64 8
   %.val9.i = load i64, ptr %10, align 8, !noalias !35, !noundef !7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val8.i) ]
   %11 = icmp eq i64 %.val9.i, %1
   br i1 %11, label %12, label %.loopexit.i
 
 12:                                               ; preds = %9
-  %.val8.i = load ptr, ptr %.ptr, align 8, !noalias !35, !nonnull !7, !align !8, !noundef !7
   %13 = getelementptr inbounds i8, ptr %.val8.i, i64 %1
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !38
   call void @llvm.lifetime.start.p0(ptr nonnull %5), !noalias !38
@@ -272,8 +279,11 @@ define noundef range(i64 0, 7) i64 @"_ZN63_$LT$log..LevelFilter$u20$as$u20$core.
 
 21:                                               ; preds = %19
   %22 = add i64 %20, 1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %17) ]
   %23 = getelementptr inbounds i8, ptr %17, i64 %20
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %18) ]
   %24 = getelementptr inbounds i8, ptr %18, i64 %20
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %24) ]
   %.fca.0.extract.val.i.i.i.i = load i8, ptr %23, align 1, !noalias !57, !noundef !7
   %.fca.1.extract.val.i.i.i.i = load i8, ptr %24, align 1, !noalias !57, !noundef !7
   %25 = add i8 %.fca.0.extract.val.i.i.i.i, -65
diff --git a/bench/meilisearch-rs/optimized/1f5rio4m04ghssoy.ll b/bench/meilisearch-rs/optimized/1f5rio4m04ghssoy.ll
index 5b7f6a1121d..eb3e66a4043 100644
--- a/bench/meilisearch-rs/optimized/1f5rio4m04ghssoy.ll
+++ b/bench/meilisearch-rs/optimized/1f5rio4m04ghssoy.ll
@@ -27,27 +27,26 @@ target triple = "x86_64-unknown-linux-gnu"
 
 ; Function Attrs: nonlazybind uwtable
 define internal fastcc void @"_ZN4core3ptr127drop_in_place$LT$std..sync..mutex..MutexGuard$LT$std..collections..hash..map..HashMap$LT$std..path..PathBuf$C$usize$GT$$GT$$GT$17he19c1a5a167e0c8aE"(ptr %.0.val, i8 %.8.val) unnamed_addr #0 {
-  %1 = icmp ne ptr %.0.val, null
-  tail call void @llvm.assume(i1 %1)
-  %2 = getelementptr inbounds nuw i8, ptr %.0.val, i64 4
-  %3 = trunc nuw i8 %.8.val to i1
-  br i1 %3, label %_ZN3std4sync6poison4Flag4done17h493818bfcfebdf65E.exit.i, label %4
-
-4:                                                ; preds = %0
-  %5 = load atomic i64, ptr @_ZN3std9panicking11panic_count18GLOBAL_PANIC_COUNT17h69e92bec4f5667f3E monotonic, align 8
-  %6 = and i64 %5, 9223372036854775807
-  %7 = icmp eq i64 %6, 0
-  br i1 %7, label %_ZN3std4sync6poison4Flag4done17h493818bfcfebdf65E.exit.i, label %8
-
-8:                                                ; preds = %4
-  %9 = tail call noundef zeroext i1 @_ZN3std9panicking11panic_count17is_zero_slow_path17heeecc5f696389655E()
-  br i1 %9, label %_ZN3std4sync6poison4Flag4done17h493818bfcfebdf65E.exit.i, label %10
-
-10:                                               ; preds = %8
-  store atomic i8 1, ptr %2 monotonic, align 1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.0.val) ]
+  %1 = getelementptr inbounds nuw i8, ptr %.0.val, i64 4
+  %2 = trunc nuw i8 %.8.val to i1
+  br i1 %2, label %_ZN3std4sync6poison4Flag4done17h493818bfcfebdf65E.exit.i, label %3
+
+3:                                                ; preds = %0
+  %4 = load atomic i64, ptr @_ZN3std9panicking11panic_count18GLOBAL_PANIC_COUNT17h69e92bec4f5667f3E monotonic, align 8
+  %5 = and i64 %4, 9223372036854775807
+  %6 = icmp eq i64 %5, 0
+  br i1 %6, label %_ZN3std4sync6poison4Flag4done17h493818bfcfebdf65E.exit.i, label %7
+
+7:                                                ; preds = %3
+  %8 = tail call noundef zeroext i1 @_ZN3std9panicking11panic_count17is_zero_slow_path17heeecc5f696389655E()
+  br i1 %8, label %_ZN3std4sync6poison4Flag4done17h493818bfcfebdf65E.exit.i, label %9
+
+9:                                                ; preds = %7
+  store atomic i8 1, ptr %1 monotonic, align 1
   br label %_ZN3std4sync6poison4Flag4done17h493818bfcfebdf65E.exit.i
 
-_ZN3std4sync6poison4Flag4done17h493818bfcfebdf65E.exit.i: ; preds = %10, %8, %4, %0
+_ZN3std4sync6poison4Flag4done17h493818bfcfebdf65E.exit.i: ; preds = %9, %7, %3, %0
   %11 = atomicrmw xchg ptr %.0.val, i32 0 release, align 4
   %12 = icmp eq i32 %11, 2
   br i1 %12, label %13, label %"_ZN79_$LT$std..sync..mutex..MutexGuard$LT$T$GT$$u20$as$u20$core..ops..drop..Drop$GT$4drop17haafa48b421243f22E.exit"
@@ -156,6 +155,7 @@ define internal fastcc { ptr, i64 } @"_ZN4core3str4iter22SplitInternal$LT$P$GT$9
   %.val = load ptr, ptr %17, align 8, !nonnull !5, !align !27, !noundef !5
   %18 = getelementptr inbounds nuw i8, ptr %0, i64 80
   %.val11 = load i64, ptr %18, align 8, !noundef !5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !28)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !31)
@@ -213,6 +213,7 @@ define internal fastcc { ptr, i64 } @"_ZN4core3str4iter22SplitInternal$LT$P$GT$9
   %42 = icmp ne i64 %30, 1
   tail call void @llvm.assume(i1 %42)
   %43 = getelementptr inbounds i8, ptr %38, i64 -2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %43) ]
   %44 = load i8, ptr %43, align 1, !noalias !46, !noundef !5
   %45 = and i8 %44, 31
   %46 = zext nneg i8 %45 to i32
@@ -227,6 +228,7 @@ define internal fastcc { ptr, i64 } @"_ZN4core3str4iter22SplitInternal$LT$P$GT$9
   %50 = icmp ne i64 %30, 2
   tail call void @llvm.assume(i1 %50)
   %51 = getelementptr inbounds i8, ptr %38, i64 -3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %51) ]
   %52 = load i8, ptr %51, align 1, !noalias !46, !noundef !5
   %53 = and i8 %52, 15
   %54 = zext nneg i8 %53 to i32
@@ -245,6 +247,7 @@ define internal fastcc { ptr, i64 } @"_ZN4core3str4iter22SplitInternal$LT$P$GT$9
   %61 = icmp ne i64 %30, 3
   tail call void @llvm.assume(i1 %61)
   %62 = getelementptr inbounds i8, ptr %38, i64 -4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %62) ]
   %63 = load i8, ptr %62, align 1, !noalias !46, !noundef !5
   %64 = and i8 %63, 7
   %65 = zext nneg i8 %64 to i32
@@ -748,6 +751,7 @@ define void @_ZN10meili_snap34default_snapshot_settings_for_test17h23bbead29b6e1
 "_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$9ends_with17h56b0c0ceaa5aa866E.exit.i": ; preds = %62
   %63 = getelementptr i8, ptr %1, i64 %2
   %64 = getelementptr i8, ptr %63, i64 -13
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %64) ]
   %bcmp.i.i.i = call i32 @bcmp(ptr noundef nonnull readonly align 1 dereferenceable(13) @anon.0d18f9b890c379d9c30b9e9e5116147c.29, ptr noundef nonnull readonly align 1 dereferenceable(13) %64, i64 13), !alias.scope !76
   %65 = icmp eq i32 %bcmp.i.i.i, 0
   %66 = add i64 %2, -13
@@ -837,6 +841,7 @@ define void @_ZN10meili_snap34default_snapshot_settings_for_test17h23bbead29b6e1
   %.val = load ptr, ptr %87, align 8, !nonnull !5, !noundef !5
   %88 = getelementptr inbounds nuw i8, ptr %36, i64 16
   %.val41 = load i64, ptr %88, align 8, !noundef !5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %35)
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %35, ptr noundef nonnull align 8 dereferenceable(24) %39, i64 24, i1 false)
   call void @llvm.experimental.noalias.scope.decl(metadata !88)
@@ -1223,6 +1228,7 @@ _ZN5alloc3fmt6format17h7fed6a266585da9dE.exit:    ; preds = %218
   call void @llvm.lifetime.end.p0(ptr nonnull %28)
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %33, ptr noundef nonnull align 8 dereferenceable(24) %29, i64 24, i1 false)
   call void @llvm.lifetime.end.p0(ptr nonnull %31)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %164) ]
   %221 = getelementptr inbounds nuw i8, ptr %164, i64 4
   br i1 %167, label %_ZN3std4sync6poison4Flag4done17h493818bfcfebdf65E.exit.i.i, label %222
 
diff --git a/bench/meshlab/optimized/paintbox.ll b/bench/meshlab/optimized/paintbox.ll
index 9fa242b26f2..637fd203860 100644
--- a/bench/meshlab/optimized/paintbox.ll
+++ b/bench/meshlab/optimized/paintbox.ll
@@ -13742,10 +13742,9 @@ define void @_ZN8Paintbox19restorePreviousTypeEv(ptr noundef nonnull readonly al
   %11 = getelementptr inbounds nuw i8, ptr %10, i64 104
   %12 = load ptr, ptr %11, align 8
   %13 = tail call noundef ptr %12(ptr noundef nonnull align 8 dereferenceable(12) %9)
-  %14 = icmp ne ptr %13, null
-  tail call void @llvm.assume(i1 %14)
-  %15 = tail call ptr @__dynamic_cast(ptr nonnull %13, ptr nonnull @_ZTI7QWidget, ptr nonnull @_ZTI11QToolButton, i64 0) #19
-  tail call void @_ZN15QAbstractButton6toggleEv(ptr noundef nonnull align 8 dereferenceable(48) %15)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %13) ]
+  %14 = tail call ptr @__dynamic_cast(ptr nonnull %13, ptr nonnull @_ZTI7QWidget, ptr nonnull @_ZTI11QToolButton, i64 0) #19
+  tail call void @_ZN15QAbstractButton6toggleEv(ptr noundef nonnull align 8 dereferenceable(48) %14)
   ret void
 }
 
diff --git a/bench/minetest/optimized/l_nodemeta.ll b/bench/minetest/optimized/l_nodemeta.ll
index f3090aadd37..465ef664c14 100644
--- a/bench/minetest/optimized/l_nodemeta.ll
+++ b/bench/minetest/optimized/l_nodemeta.ll
@@ -773,16 +773,15 @@ declare i32 @lua_isstring(ptr noundef, i32 noundef) local_unnamed_addr #0
 define dso_local void @_ZN11NodeMetaRef13handleToTableEP9lua_StateP9IMetadata(ptr noundef nonnull align 8 dereferenceable(32) %this, ptr noundef %L, ptr noundef %_meta) unnamed_addr #4 align 2 {
 entry:
   tail call void @_ZN11MetaDataRef13handleToTableEP9lua_StateP9IMetadata(ptr noundef nonnull align 8 dereferenceable(8) %this, ptr noundef %L, ptr noundef %_meta)
-  %0 = icmp ne ptr %_meta, null
-  tail call void @llvm.assume(i1 %0)
-  %1 = tail call ptr @__dynamic_cast(ptr nonnull %_meta, ptr nonnull @_ZTI9IMetadata, ptr nonnull @_ZTI12NodeMetadata, i64 -1) #24
-  %m_inventory.i = getelementptr inbounds nuw i8, ptr %1, i64 72
-  %2 = load ptr, ptr %m_inventory.i, align 8, !tbaa !126
-  %tobool.not = icmp eq ptr %2, null
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %_meta) ]
+  %0 = tail call ptr @__dynamic_cast(ptr nonnull %_meta, ptr nonnull @_ZTI9IMetadata, ptr nonnull @_ZTI12NodeMetadata, i64 -1) #24
+  %m_inventory.i = getelementptr inbounds nuw i8, ptr %0, i64 72
+  %1 = load ptr, ptr %m_inventory.i, align 8, !tbaa !126
+  %tobool.not = icmp eq ptr %1, null
   br i1 %tobool.not, label %if.else, label %if.then
 
 if.then:                                          ; preds = %entry
-  tail call void @_Z20push_inventory_listsP9lua_StateRK9Inventory(ptr noundef %L, ptr noundef nonnull align 8 dereferenceable(33) %2)
+  tail call void @_Z20push_inventory_listsP9lua_StateRK9Inventory(ptr noundef %L, ptr noundef nonnull align 8 dereferenceable(33) %1)
   br label %if.end
 
 if.else:                                          ; preds = %entry
@@ -811,11 +810,10 @@ entry:
   br i1 %call, label %if.end, label %return
 
 if.end:                                           ; preds = %entry
-  %0 = icmp ne ptr %_meta, null
-  tail call void @llvm.assume(i1 %0)
-  %1 = tail call ptr @__dynamic_cast(ptr nonnull %_meta, ptr nonnull @_ZTI9IMetadata, ptr nonnull @_ZTI12NodeMetadata, i64 -1) #24
-  %m_inventory.i = getelementptr inbounds nuw i8, ptr %1, i64 72
-  %2 = load ptr, ptr %m_inventory.i, align 8, !tbaa !126
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %_meta) ]
+  %0 = tail call ptr @__dynamic_cast(ptr nonnull %_meta, ptr nonnull @_ZTI9IMetadata, ptr nonnull @_ZTI12NodeMetadata, i64 -1) #24
+  %m_inventory.i = getelementptr inbounds nuw i8, ptr %0, i64 72
+  %1 = load ptr, ptr %m_inventory.i, align 8, !tbaa !126
   tail call void @lua_getfield(ptr noundef %L, i32 noundef %table, ptr noundef nonnull @.str.16)
   %call3 = tail call i32 @lua_type(ptr noundef %L, i32 noundef -1)
   %cmp = icmp eq i32 %call3, 5
@@ -889,7 +887,7 @@ invoke.cont11:                                    ; preds = %invoke.cont
   %10 = icmp eq ptr %call12, null
   %add.ptr = getelementptr inbounds nuw i8, ptr %call12, i64 16
   %spec.select = select i1 %10, ptr null, ptr %add.ptr
-  invoke void @_Z19read_inventory_listP9lua_StateiP9InventoryPKcP8IGameDefi(ptr noundef %L, i32 noundef -1, ptr noundef %2, ptr noundef %9, ptr noundef %spec.select, i32 noundef -1)
+  invoke void @_Z19read_inventory_listP9lua_StateiP9InventoryPKcP8IGameDefi(ptr noundef %L, i32 noundef -1, ptr noundef %1, ptr noundef %9, ptr noundef %spec.select, i32 noundef -1)
           to label %invoke.cont13 unwind label %lpad10
 
 invoke.cont13:                                    ; preds = %invoke.cont11
diff --git a/bench/mini-lsm-rs/optimized/2ysi1cyianhw3g5t.ll b/bench/mini-lsm-rs/optimized/2ysi1cyianhw3g5t.ll
index d1a6b21bed2..a07d53a2a87 100644
--- a/bench/mini-lsm-rs/optimized/2ysi1cyianhw3g5t.ll
+++ b/bench/mini-lsm-rs/optimized/2ysi1cyianhw3g5t.ll
@@ -53,6 +53,7 @@ define hidden noundef ptr @_ZN3std2io5Write9write_all17he304e79fffe0735cE(ptr no
 
 14:                                               ; preds = %9
   %.val = load ptr, ptr %7, align 8, !nonnull !5, !noundef !5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %15 = ptrtoint ptr %.val to i64
   %16 = and i64 %15, 3
   switch i64 %16, label %default.unreachable [
@@ -384,11 +385,13 @@ define hidden void @_ZN6anyhow5error11object_drop17hdd15c42e34e8fd3eE(ptr nounde
 9:                                                ; preds = %7, %1
   %10 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   call void @__rust_dealloc(ptr noundef nonnull %0, i64 noundef 16, i64 noundef 8) #26
   resume { ptr, i32 } %10
 
 "_ZN4core3ptr99drop_in_place$LT$alloc..boxed..Box$LT$anyhow..error..ErrorImpl$LT$std..io..error..Error$GT$$GT$$GT$17hf8a5ade6738e83ecE.exit": ; preds = %.noexc.i, %7
   call void @llvm.lifetime.end.p0(ptr nonnull %2), !noalias !72
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   call void @__rust_dealloc(ptr noundef nonnull %0, i64 noundef 16, i64 noundef 8) #26
   ret void
 }
@@ -403,6 +406,7 @@ define hidden noundef ptr @_ZN6anyhow5error15object_downcast17h910b7cad67d1db79E
 
 ; Function Attrs: nounwind nonlazybind uwtable
 define hidden void @_ZN6anyhow5error17object_drop_front17h5979a5a0a1a81395E(ptr noundef nonnull %0, i128 noundef %1) unnamed_addr #7 personality ptr @rust_eh_personality {
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %0, i64 noundef 16, i64 noundef 8) #26
   ret void
 }
@@ -461,6 +465,7 @@ define hidden void @"_ZN80_$LT$core..core_arch..x86..__m128i$u20$as$u20$core..co
 ; Function Attrs: nounwind nonlazybind uwtable
 define hidden void @"_ZN8triomphe3arc12Arc$LT$T$GT$9drop_slow17h9f771290ad7f2269E"(ptr noalias noundef readonly align 8 captures(none) dereferenceable(8) %0) unnamed_addr #7 personality ptr @rust_eh_personality {
   %2 = load ptr, ptr %0, align 8, !nonnull !5, !noundef !5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %2, i64 noundef 32, i64 noundef 8) #26
   ret void
 }
@@ -505,10 +510,12 @@ define hidden void @"_ZN8triomphe3arc12Arc$LT$T$GT$9drop_slow17hc0c93dbdc9469a1c
 17:                                               ; preds = %16, %15
   %18 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %2, i64 noundef 40, i64 noundef 8) #26
   resume { ptr, i32 } %18
 
 "_ZN4core3ptr351drop_in_place$LT$alloc..boxed..Box$LT$triomphe..arc..ArcInner$LT$lock_api..rwlock..RwLock$LT$parking_lot..raw_rwlock..RawRwLock$C$core..option..Option$LT$core..result..Result$LT$alloc..sync..Arc$LT$mini_lsm_starter..block..Block$GT$$C$alloc..sync..Arc$LT$dyn$u20$core..any..Any$u2b$core..marker..Send$u2b$core..marker..Sync$GT$$GT$$GT$$GT$$GT$$GT$$GT$17hb5c31de2e99d4282E.exit": ; preds = %1, %10, %15, %16
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %2, i64 noundef 40, i64 noundef 8) #26
   ret void
 }
@@ -516,6 +523,7 @@ define hidden void @"_ZN8triomphe3arc12Arc$LT$T$GT$9drop_slow17hc0c93dbdc9469a1c
 ; Function Attrs: nounwind nonlazybind uwtable
 define hidden void @"_ZN8triomphe3arc12Arc$LT$T$GT$9drop_slow17hca5d343cb6183e14E"(ptr noalias noundef readonly align 8 captures(none) dereferenceable(8) %0) unnamed_addr #7 personality ptr @rust_eh_personality {
   %2 = load ptr, ptr %0, align 8, !nonnull !5, !noundef !5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %2, i64 noundef 16, i64 noundef 8) #26
   ret void
 }
@@ -560,6 +568,7 @@ define hidden void @"_ZN8triomphe3arc12Arc$LT$T$GT$9drop_slow17hf8dd516bba673eed
           to label %.noexc.i unwind label %20
 
 .noexc.i:                                         ; preds = %15
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %16) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %16, i64 noundef 32, i64 noundef 8) #26, !noalias !121
   br label %"_ZN4core3ptr199drop_in_place$LT$alloc..boxed..Box$LT$triomphe..arc..ArcInner$LT$moka..common..concurrent..ValueEntry$LT$$LP$usize$C$usize$RP$$C$alloc..sync..Arc$LT$mini_lsm_starter..block..Block$GT$$GT$$GT$$GT$$GT$17ha76b0d8a670e9423E.exit"
 
@@ -576,10 +585,12 @@ define hidden void @"_ZN8triomphe3arc12Arc$LT$T$GT$9drop_slow17hf8dd516bba673eed
 
 22:                                               ; preds = %20, %8
   %eh.lpad-body.i = phi { ptr, i32 } [ %21, %20 ], [ %9, %8 ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %2, i64 noundef 48, i64 noundef 8) #26
   resume { ptr, i32 } %eh.lpad-body.i
 
 "_ZN4core3ptr199drop_in_place$LT$alloc..boxed..Box$LT$triomphe..arc..ArcInner$LT$moka..common..concurrent..ValueEntry$LT$$LP$usize$C$usize$RP$$C$alloc..sync..Arc$LT$mini_lsm_starter..block..Block$GT$$GT$$GT$$GT$$GT$17ha76b0d8a670e9423E.exit": ; preds = %"_ZN4core3ptr75drop_in_place$LT$alloc..sync..Arc$LT$mini_lsm_starter..block..Block$GT$$GT$17h0c660c363b45c0dcE.llvm.8684371289217427975.exit.i.i.i", %.noexc.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %2, i64 noundef 48, i64 noundef 8) #26
   ret void
 }
@@ -614,6 +625,7 @@ define hidden noundef ptr @"_ZN91_$LT$hashbrown..raw..RawIter$LT$T$GT$$u20$as$u2
   %.val911.i = phi ptr [ %.promoted.i, %.lr.ph.i ], [ %13, %9 ]
   %11 = load <16 x i8>, ptr %10, align 16, !noalias !130
   %12 = icmp sgt <16 x i8> %11, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911.i) ]
   %13 = getelementptr inbounds i8, ptr %.val911.i, i64 -256
   %14 = getelementptr inbounds nuw i8, ptr %10, i64 16
   %.cast.i = bitcast <16 x i1> %12 to i16
@@ -628,6 +640,7 @@ define hidden noundef ptr @"_ZN91_$LT$hashbrown..raw..RawIter$LT$T$GT$$u20$as$u2
   %17 = add i16 %.lcssa.i, -1
   %18 = and i16 %17, %.lcssa.i
   store i16 %18, ptr %6, align 8, !alias.scope !127
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3.i) ]
   %19 = sub nsw i64 0, %16
   %20 = getelementptr inbounds { i64, ptr }, ptr %.val3.i, i64 %19
   %21 = add i64 %3, -1
@@ -669,6 +682,7 @@ define hidden noundef ptr @"_ZN91_$LT$hashbrown..raw..RawIter$LT$T$GT$$u20$as$u2
   %.val911.i = phi ptr [ %.promoted.i, %.lr.ph.i ], [ %13, %9 ]
   %11 = load <16 x i8>, ptr %10, align 16, !noalias !139
   %12 = icmp sgt <16 x i8> %11, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911.i) ]
   %13 = getelementptr inbounds i8, ptr %.val911.i, i64 -64
   %14 = getelementptr inbounds nuw i8, ptr %10, i64 16
   %.cast.i = bitcast <16 x i1> %12 to i16
@@ -683,6 +697,7 @@ define hidden noundef ptr @"_ZN91_$LT$hashbrown..raw..RawIter$LT$T$GT$$u20$as$u2
   %17 = add i16 %.lcssa.i, -1
   %18 = and i16 %17, %.lcssa.i
   store i16 %18, ptr %6, align 8, !alias.scope !136
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3.i) ]
   %19 = sub nsw i64 0, %16
   %20 = getelementptr inbounds i32, ptr %.val3.i, i64 %19
   %21 = add i64 %3, -1
@@ -724,6 +739,7 @@ define hidden noundef ptr @"_ZN91_$LT$hashbrown..raw..RawIter$LT$T$GT$$u20$as$u2
   %.val911.i = phi ptr [ %.promoted.i, %.lr.ph.i ], [ %13, %9 ]
   %11 = load <16 x i8>, ptr %10, align 16, !noalias !148
   %12 = icmp sgt <16 x i8> %11, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911.i) ]
   %13 = getelementptr inbounds i8, ptr %.val911.i, i64 -1152
   %14 = getelementptr inbounds nuw i8, ptr %10, i64 16
   %.cast.i = bitcast <16 x i1> %12 to i16
@@ -738,6 +754,7 @@ define hidden noundef ptr @"_ZN91_$LT$hashbrown..raw..RawIter$LT$T$GT$$u20$as$u2
   %17 = add i16 %.lcssa.i, -1
   %18 = and i16 %17, %.lcssa.i
   store i16 %18, ptr %6, align 8, !alias.scope !145
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3.i) ]
   %19 = sub nsw i64 0, %16
   %20 = getelementptr inbounds { { { { i64, ptr }, i64 } }, { { { { i64, ptr }, i64 } }, { ptr, ptr }, i64 } }, ptr %.val3.i, i64 %19
   %21 = add i64 %3, -1
@@ -870,6 +887,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner13drop_elements17h1960b0817b
   %.val911.i.i = phi ptr [ %15, %.lr.ph.i.i ], [ %.sroa.03.018, %11 ]
   %13 = load <16 x i8>, ptr %12, align 16, !noalias !156
   %14 = icmp sgt <16 x i8> %13, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911.i.i) ]
   %15 = getelementptr inbounds i8, ptr %.val911.i.i, i64 -256
   %16 = getelementptr inbounds nuw i8, ptr %12, i64 16
   %.cast.i.i = bitcast <16 x i1> %14 to i16
@@ -882,6 +900,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner13drop_elements17h1960b0817b
   %.lcssa.i.i = phi i16 [ %.sroa.84.015, %11 ], [ %.cast.i.i, %.lr.ph.i.i ]
   %17 = add i16 %.lcssa.i.i, -1
   %18 = and i16 %17, %.lcssa.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.03.1) ]
   %19 = add i64 %.sroa.105.016, -1
   %20 = tail call range(i16 0, 17) i16 @llvm.cttz.i16(i16 %.lcssa.i.i, i1 true)
   %21 = zext nneg i16 %20 to i64
@@ -945,6 +964,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner13drop_elements17hdff477a9b6
   %.val911.i.i = phi ptr [ %18, %.lr.ph.i.i ], [ %.sroa.03.019, %14 ]
   %16 = load <16 x i8>, ptr %15, align 16, !noalias !182
   %17 = icmp sgt <16 x i8> %16, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911.i.i) ]
   %18 = getelementptr inbounds i8, ptr %.val911.i.i, i64 -1152
   %19 = getelementptr inbounds nuw i8, ptr %15, i64 16
   %.cast.i.i = bitcast <16 x i1> %17 to i16
@@ -959,6 +979,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner13drop_elements17hdff477a9b6
   %21 = zext nneg i16 %20 to i64
   %22 = add i16 %.lcssa.i.i, -1
   %23 = and i16 %22, %.lcssa.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.03.1) ]
   %24 = sub nsw i64 0, %21
   %25 = getelementptr inbounds { { { { i64, ptr }, i64 } }, { { { { i64, ptr }, i64 } }, { ptr, ptr }, i64 } }, ptr %.sroa.03.1, i64 %24
   %26 = add i64 %.sroa.105.017, -1
@@ -1115,6 +1136,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner16drop_inner_table17h8881906
   %.val911.i.i.i = phi ptr [ %22, %.lr.ph.i.i.i ], [ %.sroa.03.018.i, %18 ]
   %20 = load <16 x i8>, ptr %19, align 16, !noalias !217
   %21 = icmp sgt <16 x i8> %20, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911.i.i.i) ]
   %22 = getelementptr inbounds i8, ptr %.val911.i.i.i, i64 -256
   %23 = getelementptr inbounds nuw i8, ptr %19, i64 16
   %.cast.i.i.i = bitcast <16 x i1> %21 to i16
@@ -1127,6 +1149,7 @@ define hidden void @_ZN9hashbrown3raw13RawTableInner16drop_inner_table17h8881906
   %.lcssa.i.i.i = phi i16 [ %.sroa.84.015.i, %18 ], [ %.cast.i.i.i, %.lr.ph.i.i.i ]
   %24 = add i16 %.lcssa.i.i.i, -1
   %25 = and i16 %24, %.lcssa.i.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.03.1.i) ]
   %26 = add i64 %.sroa.105.016.i, -1
   %27 = tail call range(i16 0, 17) i16 @llvm.cttz.i16(i16 %.lcssa.i.i.i, i1 true)
   %28 = zext nneg i16 %27 to i64
@@ -1322,7 +1345,7 @@ define hidden void @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$3new17hec1f4442d8ff
   ret void
 }
 
-; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable
+; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: write, target_mem0: none, target_mem1: none) uwtable
 define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9next_impl17h9d9fa56a7fcb32ebE.llvm.13249522725285578715"(ptr noalias noundef align 8 captures(none) dereferenceable(32) %0) unnamed_addr #13 {
   %2 = getelementptr inbounds nuw i8, ptr %0, i64 24
   %3 = load i16, ptr %2, align 8, !alias.scope !271, !noundef !5
@@ -1348,6 +1371,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   %7 = add i16 %.lcssa, -1
   %8 = and i16 %7, %.lcssa
   store i16 %8, ptr %2, align 8, !alias.scope !271
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3) ]
   %9 = sub nsw i64 0, %6
   %10 = getelementptr inbounds { i64, ptr }, ptr %.val3, i64 %9
   ret ptr %10
@@ -1357,6 +1381,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   %.val911 = phi ptr [ %.promoted, %.lr.ph ], [ %15, %11 ]
   %13 = load <16 x i8>, ptr %12, align 16, !noalias !274
   %14 = icmp sgt <16 x i8> %13, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911) ]
   %15 = getelementptr inbounds i8, ptr %.val911, i64 -256
   %16 = getelementptr inbounds nuw i8, ptr %12, i64 16
   %.cast = bitcast <16 x i1> %14 to i16
@@ -1364,7 +1389,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   br i1 %.not.not.i, label %11, label %._crit_edge
 }
 
-; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable
+; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: write, target_mem0: none, target_mem1: none) uwtable
 define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9next_impl17hc4c134bc9dc60071E.llvm.13249522725285578715"(ptr noalias noundef align 8 captures(none) dereferenceable(32) %0) unnamed_addr #13 {
   %2 = getelementptr inbounds nuw i8, ptr %0, i64 24
   %3 = load i16, ptr %2, align 8, !alias.scope !277, !noundef !5
@@ -1390,6 +1415,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   %7 = add i16 %.lcssa, -1
   %8 = and i16 %7, %.lcssa
   store i16 %8, ptr %2, align 8, !alias.scope !277
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3) ]
   %9 = sub nsw i64 0, %6
   %10 = getelementptr inbounds { { { { i64, ptr }, i64 } }, { { { { i64, ptr }, i64 } }, { ptr, ptr }, i64 } }, ptr %.val3, i64 %9
   ret ptr %10
@@ -1399,6 +1425,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   %.val911 = phi ptr [ %.promoted, %.lr.ph ], [ %15, %11 ]
   %13 = load <16 x i8>, ptr %12, align 16, !noalias !280
   %14 = icmp sgt <16 x i8> %13, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911) ]
   %15 = getelementptr inbounds i8, ptr %.val911, i64 -1152
   %16 = getelementptr inbounds nuw i8, ptr %12, i64 16
   %.cast = bitcast <16 x i1> %14 to i16
@@ -1406,7 +1433,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   br i1 %.not.not.i, label %11, label %._crit_edge
 }
 
-; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable
+; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: write, target_mem0: none, target_mem1: none) uwtable
 define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9next_impl17he96b67e0b4b6e4fbE.llvm.13249522725285578715"(ptr noalias noundef align 8 captures(none) dereferenceable(32) %0) unnamed_addr #13 {
   %2 = getelementptr inbounds nuw i8, ptr %0, i64 24
   %3 = load i16, ptr %2, align 8, !alias.scope !283, !noundef !5
@@ -1432,6 +1459,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   %7 = add i16 %.lcssa, -1
   %8 = and i16 %7, %.lcssa
   store i16 %8, ptr %2, align 8, !alias.scope !283
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3) ]
   %9 = sub nsw i64 0, %6
   %10 = getelementptr inbounds i32, ptr %.val3, i64 %9
   ret ptr %10
@@ -1441,6 +1469,7 @@ define hidden noundef nonnull ptr @"_ZN9hashbrown3raw21RawIterRange$LT$T$GT$9nex
   %.val911 = phi ptr [ %.promoted, %.lr.ph ], [ %15, %11 ]
   %13 = load <16 x i8>, ptr %12, align 16, !noalias !286
   %14 = icmp sgt <16 x i8> %13, splat (i8 -1)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val911) ]
   %15 = getelementptr inbounds i8, ptr %.val911, i64 -64
   %16 = getelementptr inbounds nuw i8, ptr %12, i64 16
   %.cast = bitcast <16 x i1> %14 to i16
@@ -1654,7 +1683,7 @@ attributes #9 = { nofree norecurse nosync nounwind nonlazybind memory(read, argm
 attributes #10 = { inlinehint mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: write, inaccessiblemem: write) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #11 = { inlinehint mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #12 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: readwrite) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #13 = { nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #13 = { nofree norecurse nosync nounwind nonlazybind memory(read, argmem: readwrite, inaccessiblemem: write, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #14 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #15 = { cold noreturn nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #16 = { mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
diff --git a/bench/mini-lsm-rs/optimized/56vhdkxtzvzc0a1c.ll b/bench/mini-lsm-rs/optimized/56vhdkxtzvzc0a1c.ll
index 14cb2abf456..8116dcb695f 100644
--- a/bench/mini-lsm-rs/optimized/56vhdkxtzvzc0a1c.ll
+++ b/bench/mini-lsm-rs/optimized/56vhdkxtzvzc0a1c.ll
@@ -1473,8 +1473,7 @@ define hidden void @"_ZN5alloc11collections5btree8navigate75LazyLeafRange$LT$all
   br label %13
 
 7:                                                ; preds = %4
-  %8 = icmp ne ptr %.sroa.4.sroa.4.0.copyload, null
-  tail call void @llvm.assume(i1 %8)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.4.sroa.4.0.copyload) ]
   %.not11.i = icmp eq i64 %.sroa.4.sroa.5.0.copyload, 0
   br i1 %.not11.i, label %"_ZN5alloc11collections5btree8navigate142_$LT$impl$u20$alloc..collections..btree..node..NodeRef$LT$BorrowType$C$K$C$V$C$alloc..collections..btree..node..marker..LeafOrInternal$GT$$GT$15first_leaf_edge17h9217d05fd4f8a77dE.llvm.1533238098547642317.exit", label %.lr.ph.i
 
@@ -1528,8 +1527,7 @@ define hidden void @"_ZN5alloc11collections5btree8navigate75LazyLeafRange$LT$all
   br label %13
 
 7:                                                ; preds = %4
-  %8 = icmp ne ptr %.sroa.4.sroa.4.0.copyload, null
-  tail call void @llvm.assume(i1 %8)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.4.sroa.4.0.copyload) ]
   %.not11.i = icmp eq i64 %.sroa.4.sroa.5.0.copyload, 0
   br i1 %.not11.i, label %"_ZN5alloc11collections5btree8navigate142_$LT$impl$u20$alloc..collections..btree..node..NodeRef$LT$BorrowType$C$K$C$V$C$alloc..collections..btree..node..marker..LeafOrInternal$GT$$GT$15first_leaf_edge17hd832304ec3fd3eddE.llvm.1533238098547642317.exit", label %.lr.ph.i
 
diff --git a/bench/mini-lsm-rs/optimized/pew1bqmcl3zb6gg.ll b/bench/mini-lsm-rs/optimized/pew1bqmcl3zb6gg.ll
index e3060fda396..78965c41f22 100644
--- a/bench/mini-lsm-rs/optimized/pew1bqmcl3zb6gg.ll
+++ b/bench/mini-lsm-rs/optimized/pew1bqmcl3zb6gg.ll
@@ -737,7 +737,8 @@ default.unreachable10:                            ; preds = %3
   br label %"_ZN99_$LT$crossbeam_channel..flavors..at..Channel$u20$as$u20$crossbeam_channel..select..SelectHandle$GT$10try_select17h5af93ce364f752b7E.exit"
 
 14:                                               ; preds = %3
-  %.val = load ptr, ptr %2, align 8, !nonnull !5, !noundef !5
+  %.val = load ptr, ptr %2, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %15 = getelementptr inbounds nuw i8, ptr %.val, i64 40
   %16 = load atomic i64, ptr %15 acquire, align 8
   %17 = icmp eq i64 %16, 0
@@ -920,7 +921,8 @@ default.unreachable10:                            ; preds = %3
   br label %"_ZN99_$LT$crossbeam_channel..flavors..at..Channel$u20$as$u20$crossbeam_channel..select..SelectHandle$GT$10try_select17h5af93ce364f752b7E.exit"
 
 14:                                               ; preds = %3
-  %.val = load ptr, ptr %2, align 8, !nonnull !5, !noundef !5
+  %.val = load ptr, ptr %2, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %15 = getelementptr inbounds nuw i8, ptr %.val, i64 40
   %16 = load atomic i64, ptr %15 acquire, align 8
   %17 = icmp eq i64 %16, 0
@@ -1859,6 +1861,7 @@ common.resume:                                    ; preds = %.body, %23
   %.0 = phi i8 [ %46, %43 ], [ 0, %39 ]
   %48 = getelementptr inbounds nuw i8, ptr %0, i64 56
   store atomic i8 %.0, ptr %48 seq_cst, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   %49 = trunc nuw i8 %.0.i.i.i to i1
   br i1 %49, label %_ZN3std4sync6poison4Flag4done17h5bffa24fa61aa5e0E.exit.i.i, label %50
 
@@ -2215,27 +2218,26 @@ default.unreachable35:                            ; preds = %2
 
 ; Function Attrs: nonlazybind uwtable
 define internal fastcc void @"_ZN4core3ptr88drop_in_place$LT$std..sync..mutex..MutexGuard$LT$crossbeam_channel..waker..Waker$GT$$GT$17h7af576d7a64c4377E"(ptr %.0.val, i8 %.8.val) unnamed_addr #0 {
-  %1 = icmp ne ptr %.0.val, null
-  tail call void @llvm.assume(i1 %1)
-  %2 = getelementptr inbounds nuw i8, ptr %.0.val, i64 4
-  %3 = trunc nuw i8 %.8.val to i1
-  br i1 %3, label %_ZN3std4sync6poison4Flag4done17h5bffa24fa61aa5e0E.exit.i, label %4
-
-4:                                                ; preds = %0
-  %5 = load atomic i64, ptr @_ZN3std9panicking11panic_count18GLOBAL_PANIC_COUNT17ha93a1baa6fc65cd0E monotonic, align 8
-  %6 = and i64 %5, 9223372036854775807
-  %7 = icmp eq i64 %6, 0
-  br i1 %7, label %_ZN3std4sync6poison4Flag4done17h5bffa24fa61aa5e0E.exit.i, label %_ZN3std9panicking11panic_count13count_is_zero17h66cf19443d869469E.exit.i.i
-
-_ZN3std9panicking11panic_count13count_is_zero17h66cf19443d869469E.exit.i.i: ; preds = %4
-  %8 = tail call noundef zeroext i1 @_ZN3std9panicking11panic_count17is_zero_slow_path17h658c934b8397a2acE()
-  br i1 %8, label %_ZN3std4sync6poison4Flag4done17h5bffa24fa61aa5e0E.exit.i, label %9
-
-9:                                                ; preds = %_ZN3std9panicking11panic_count13count_is_zero17h66cf19443d869469E.exit.i.i
-  store atomic i8 1, ptr %2 monotonic, align 1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.0.val) ]
+  %1 = getelementptr inbounds nuw i8, ptr %.0.val, i64 4
+  %2 = trunc nuw i8 %.8.val to i1
+  br i1 %2, label %_ZN3std4sync6poison4Flag4done17h5bffa24fa61aa5e0E.exit.i, label %3
+
+3:                                                ; preds = %0
+  %4 = load atomic i64, ptr @_ZN3std9panicking11panic_count18GLOBAL_PANIC_COUNT17ha93a1baa6fc65cd0E monotonic, align 8
+  %5 = and i64 %4, 9223372036854775807
+  %6 = icmp eq i64 %5, 0
+  br i1 %6, label %_ZN3std4sync6poison4Flag4done17h5bffa24fa61aa5e0E.exit.i, label %_ZN3std9panicking11panic_count13count_is_zero17h66cf19443d869469E.exit.i.i
+
+_ZN3std9panicking11panic_count13count_is_zero17h66cf19443d869469E.exit.i.i: ; preds = %3
+  %7 = tail call noundef zeroext i1 @_ZN3std9panicking11panic_count17is_zero_slow_path17h658c934b8397a2acE()
+  br i1 %7, label %_ZN3std4sync6poison4Flag4done17h5bffa24fa61aa5e0E.exit.i, label %8
+
+8:                                                ; preds = %_ZN3std9panicking11panic_count13count_is_zero17h66cf19443d869469E.exit.i.i
+  store atomic i8 1, ptr %1 monotonic, align 1
   br label %_ZN3std4sync6poison4Flag4done17h5bffa24fa61aa5e0E.exit.i
 
-_ZN3std4sync6poison4Flag4done17h5bffa24fa61aa5e0E.exit.i: ; preds = %9, %_ZN3std9panicking11panic_count13count_is_zero17h66cf19443d869469E.exit.i.i, %4, %0
+_ZN3std4sync6poison4Flag4done17h5bffa24fa61aa5e0E.exit.i: ; preds = %8, %_ZN3std9panicking11panic_count13count_is_zero17h66cf19443d869469E.exit.i.i, %3, %0
   %10 = atomicrmw xchg ptr %.0.val, i32 0 release, align 4
   %11 = icmp eq i32 %10, 2
   br i1 %11, label %12, label %"_ZN79_$LT$std..sync..mutex..MutexGuard$LT$T$GT$$u20$as$u20$core..ops..drop..Drop$GT$4drop17h4a7cd94354db338dE.exit"
diff --git a/bench/mitsuba3/optimized/builder.ll b/bench/mitsuba3/optimized/builder.ll
index ac1cf2255fb..2ad95565ee2 100644
--- a/bench/mitsuba3/optimized/builder.ll
+++ b/bench/mitsuba3/optimized/builder.ll
@@ -2183,7 +2183,7 @@ define dso_local noundef i32 @_ZN6asmjit9_abi_1_1011BaseBuilder5alignENS0_9Align
   %5 = getelementptr inbounds nuw i8, ptr %0, i64 48
   %6 = load ptr, ptr %5, align 8, !tbaa !46
   %7 = icmp eq ptr %6, null
-  br i1 %7, label %55, label %8, !prof !15
+  br i1 %7, label %54, label %8, !prof !15
 
 8:                                                ; preds = %3
   %9 = getelementptr inbounds nuw i8, ptr %0, i64 240
@@ -2212,70 +2212,69 @@ define dso_local noundef i32 @_ZN6asmjit9_abi_1_1011BaseBuilder5alignENS0_9Align
 20:                                               ; preds = %8
   %21 = call noundef i32 @_ZN6asmjit9_abi_1_1011BaseEmitter11reportErrorEjPKc(ptr noundef nonnull align 8 dereferenceable(144) %0, i32 noundef 1, ptr noundef null)
   %22 = icmp eq i32 %21, 0
-  br i1 %22, label %23, label %55
+  br i1 %22, label %23, label %54
 
 23:                                               ; preds = %20, %12
-  %24 = icmp ne ptr %10, null
-  call void @llvm.assume(i1 %24)
-  %25 = getelementptr inbounds nuw i8, ptr %0, i64 384
-  %26 = load ptr, ptr %25, align 8, !tbaa !63
-  %27 = icmp eq ptr %26, null
-  br i1 %27, label %28, label %37
-
-28:                                               ; preds = %23
-  %29 = getelementptr inbounds nuw i8, ptr %0, i64 392
-  %30 = load ptr, ptr %29, align 8, !tbaa !64
-  %31 = icmp eq ptr %30, null
-  br i1 %31, label %32, label %34
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %10) ]
+  %24 = getelementptr inbounds nuw i8, ptr %0, i64 384
+  %25 = load ptr, ptr %24, align 8, !tbaa !63
+  %26 = icmp eq ptr %25, null
+  br i1 %26, label %27, label %36
+
+27:                                               ; preds = %23
+  %28 = getelementptr inbounds nuw i8, ptr %0, i64 392
+  %29 = load ptr, ptr %28, align 8, !tbaa !64
+  %30 = icmp eq ptr %29, null
+  br i1 %30, label %31, label %33
+
+28:                                               ; preds = %27
+  store ptr %10, ptr %28, align 8, !tbaa !64
+  %32 = getelementptr inbounds nuw i8, ptr %0, i64 400
+  br label %43
 
-32:                                               ; preds = %28
-  store ptr %10, ptr %29, align 8, !tbaa !64
-  %33 = getelementptr inbounds nuw i8, ptr %0, i64 400
-  br label %44
+32:                                               ; preds = %27
+  %34 = getelementptr inbounds nuw i8, ptr %10, i64 8
+  store ptr %29, ptr %34, align 8, !tbaa !16
+  %35 = load ptr, ptr %28, align 8, !tbaa !64
+  store ptr %10, ptr %35, align 8, !tbaa !16
+  br label %43
 
-34:                                               ; preds = %28
-  %35 = getelementptr inbounds nuw i8, ptr %10, i64 8
-  store ptr %30, ptr %35, align 8, !tbaa !16
-  %36 = load ptr, ptr %29, align 8, !tbaa !64
-  store ptr %10, ptr %36, align 8, !tbaa !16
-  br label %44
+34:                                               ; preds = %23
+  %35 = getelementptr inbounds nuw i8, ptr %25, i64 8
+  %38 = load ptr, ptr %35, align 8, !tbaa !16
+  store ptr %25, ptr %10, align 8, !tbaa !16
+  %39 = getelementptr inbounds nuw i8, ptr %10, i64 8
+  store ptr %38, ptr %39, align 8, !tbaa !16
+  store ptr %10, ptr %37, align 8, !tbaa !16
+  %40 = icmp eq ptr %38, null
+  %41 = getelementptr inbounds nuw i8, ptr %0, i64 400
+  %42 = select i1 %40, ptr %41, ptr %38
+  br label %43
 
-37:                                               ; preds = %23
-  %38 = getelementptr inbounds nuw i8, ptr %26, i64 8
-  %39 = load ptr, ptr %38, align 8, !tbaa !16
-  store ptr %26, ptr %10, align 8, !tbaa !16
-  %40 = getelementptr inbounds nuw i8, ptr %10, i64 8
-  store ptr %39, ptr %40, align 8, !tbaa !16
-  store ptr %10, ptr %38, align 8, !tbaa !16
-  %41 = icmp eq ptr %39, null
-  %42 = getelementptr inbounds nuw i8, ptr %0, i64 400
-  %43 = select i1 %41, ptr %42, ptr %39
-  br label %44
+37:                                               ; preds = %36, %33, %31
+  %44 = phi ptr [ %32, %31 ], [ %28, %33 ], [ %42, %36 ]
+  store ptr %10, ptr %44, align 8, !tbaa !16
+  %45 = getelementptr inbounds nuw i8, ptr %10, i64 17
+  %46 = load i8, ptr %45, align 1, !tbaa !61
+  %47 = or i8 %46, -128
+  store i8 %47, ptr %45, align 1, !tbaa !61
+  %48 = getelementptr inbounds nuw i8, ptr %10, i64 16
+  %49 = load i8, ptr %48, align 8, !tbaa !16
+  %50 = icmp eq i8 %49, 2
+  br i1 %50, label %51, label %44
+
+51:                                               ; preds = %43
+  %52 = getelementptr inbounds nuw i8, ptr %0, i64 409
+  store i8 1, ptr %52, align 1, !tbaa !65
+  br label %53
 
-44:                                               ; preds = %37, %34, %32
-  %45 = phi ptr [ %33, %32 ], [ %29, %34 ], [ %43, %37 ]
-  store ptr %10, ptr %45, align 8, !tbaa !16
-  %46 = getelementptr inbounds nuw i8, ptr %10, i64 17
-  %47 = load i8, ptr %46, align 1, !tbaa !61
-  %48 = or i8 %47, -128
-  store i8 %48, ptr %46, align 1, !tbaa !61
-  %49 = getelementptr inbounds nuw i8, ptr %10, i64 16
-  %50 = load i8, ptr %49, align 8, !tbaa !16
-  %51 = icmp eq i8 %50, 2
-  br i1 %51, label %52, label %54
-
-52:                                               ; preds = %44
-  %53 = getelementptr inbounds nuw i8, ptr %0, i64 409
-  store i8 1, ptr %53, align 1, !tbaa !65
+44:                                               ; preds = %51, %43
+  store ptr %10, ptr %24, align 8, !tbaa !63
   br label %54
 
-54:                                               ; preds = %52, %44
-  store ptr %10, ptr %25, align 8, !tbaa !63
-  br label %55
-
-55:                                               ; preds = %54, %20, %3
-  %56 = phi i32 [ 5, %3 ], [ 0, %54 ], [ %21, %20 ]
-  ret i32 %56
+54:                                               ; preds = %53, %20, %3
+  %55 = phi i32 [ 5, %3 ], [ 0, %53 ], [ %21, %20 ]
+  ret i32 %55
 }
 
 ; Function Attrs: mustprogress uwtable
diff --git a/bench/mitsuba3/optimized/rapass.ll b/bench/mitsuba3/optimized/rapass.ll
index 20ba5b7c9b5..706fba41e74 100644
--- a/bench/mitsuba3/optimized/rapass.ll
+++ b/bench/mitsuba3/optimized/rapass.ll
@@ -1499,8 +1499,8 @@ define hidden noundef i32 @_ZN6asmjit9_abi_1_1010BaseRAPass18buildCFGDominatorsE
   br label %32
 
 32:                                               ; preds = %100, %30
-  %33 = phi i64 [ %31, %30 ], [ %35, %100 ]
-  %34 = phi i8 [ 0, %30 ], [ %101, %100 ]
+  %33 = phi i64 [ %31, %30 ], [ %35, %99 ]
+  %34 = phi i8 [ 0, %30 ], [ %101, %99 ]
   %35 = add nsw i64 %33, -1
   %36 = load ptr, ptr %21, align 8, !tbaa !9
   %37 = getelementptr inbounds nuw ptr, ptr %36, i64 %35
@@ -1591,24 +1591,23 @@ define hidden noundef i32 @_ZN6asmjit9_abi_1_1010BaseRAPass18buildCFGDominatorsE
   br i1 %90, label %100, label %91
 
 91:                                               ; preds = %.loopexit18
-  %92 = icmp ne ptr %87, null
-  tail call void @llvm.assume(i1 %92)
-  br i1 %9, label %99, label %93
-
-93:                                               ; preds = %91
-  %94 = getelementptr inbounds nuw i8, ptr %38, i64 8
-  %95 = load i32, ptr %94, align 8, !tbaa !144
-  %96 = getelementptr inbounds nuw i8, ptr %87, i64 8
-  %97 = load i32, ptr %96, align 8, !tbaa !144
-  %98 = tail call noundef i32 (ptr, ptr, ...) @_ZN6asmjit9_abi_1_106Logger4logfEPKcz(ptr noundef nonnull align 8 dereferenceable(20) %7, ptr noundef nonnull @.str.6, i32 noundef %95, i32 noundef %97) #17
-  br label %99
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %87) ]
+  br i1 %9, label %98, label %92
+
+92:                                               ; preds = %91
+  %93 = getelementptr inbounds nuw i8, ptr %38, i64 8
+  %94 = load i32, ptr %93, align 8, !tbaa !144
+  %95 = getelementptr inbounds nuw i8, ptr %87, i64 8
+  %96 = load i32, ptr %95, align 8, !tbaa !144
+  %97 = tail call noundef i32 (ptr, ptr, ...) @_ZN6asmjit9_abi_1_106Logger4logfEPKcz(ptr noundef nonnull align 8 dereferenceable(20) %7, ptr noundef nonnull @.str.6, i32 noundef %94, i32 noundef %96) #17
+  br label %98
 
-99:                                               ; preds = %93, %91
+99:                                               ; preds = %92, %91
   store ptr %87, ptr %88, align 8, !tbaa !168
   br label %100
 
 100:                                              ; preds = %99, %.loopexit18, %32
-  %101 = phi i8 [ %34, %32 ], [ 1, %99 ], [ %34, %.loopexit18 ]
+  %101 = phi i8 [ %34, %32 ], [ 1, %98 ], [ %34, %.loopexit18 ]
   %102 = icmp eq i64 %35, 0
   br i1 %102, label %23, label %32
 
diff --git a/bench/opencv/optimized/node.ll b/bench/opencv/optimized/node.ll
index 785e72dd0c1..1733d189587 100644
--- a/bench/opencv/optimized/node.ll
+++ b/bench/opencv/optimized/node.ll
@@ -908,8 +908,6 @@ _ZN9__gnu_cxx27__exchange_and_add_dispatchEPii.exit.i.i.i.i.i: ; preds = %30, %2
   br label %_ZNK3ade6HandleINS_4EdgeEEptEv.exit
 
 _ZNK3ade6HandleINS_4EdgeEEptEv.exit:              ; preds = %18, %_ZN9__gnu_cxx27__exchange_and_add_dispatchEPii.exit.i.i.i.i.i, %33
-  %34 = icmp ne ptr %14, null
-  tail call void @llvm.assume(i1 %34)
   tail call void @_ZNK3ade4Edge7srcNodeEv(ptr dead_on_unwind writable sret(%"class.ade::Handle.55") align 8 %0, ptr noundef nonnull align 8 dereferenceable(32) %14)
   ret void
 }
@@ -980,8 +978,6 @@ _ZN9__gnu_cxx27__exchange_and_add_dispatchEPii.exit.i.i.i.i.i: ; preds = %30, %2
   br label %_ZNK3ade6HandleINS_4EdgeEEptEv.exit
 
 _ZNK3ade6HandleINS_4EdgeEEptEv.exit:              ; preds = %18, %_ZN9__gnu_cxx27__exchange_and_add_dispatchEPii.exit.i.i.i.i.i, %33
-  %34 = icmp ne ptr %14, null
-  tail call void @llvm.assume(i1 %34)
   tail call void @_ZNK3ade4Edge7dstNodeEv(ptr dead_on_unwind writable sret(%"class.ade::Handle.55") align 8 %0, ptr noundef nonnull align 8 dereferenceable(32) %14)
   ret void
 }
diff --git a/bench/opencv/optimized/ransac_solvers.ll b/bench/opencv/optimized/ransac_solvers.ll
index 114c1abbf31..855b7a5c61e 100644
--- a/bench/opencv/optimized/ransac_solvers.ll
+++ b/bench/opencv/optimized/ransac_solvers.ll
@@ -11039,8 +11039,7 @@ _ZNSt6vectorIN2cv3MatESaIS1_EED2Ev.exit427:       ; preds = %.thread1322, %_ZSt8
   call void @llvm.experimental.noalias.scope.decl(metadata !450)
   %730 = load ptr, ptr %729, align 8, !tbaa !426, !noalias !453, !nonnull !102, !noundef !102
   %731 = call ptr @__dynamic_cast(ptr nonnull %730, ptr nonnull @_ZTIN2cv4usac7SamplerE, ptr nonnull @_ZTIN2cv4usac13ProsacSamplerE, i64 0) #28, !noalias !453
-  %.not.not.i.i = icmp ne ptr %731, null
-  call void @llvm.assume(i1 %.not.not.i.i)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %731) ]
   %732 = getelementptr inbounds nuw i8, ptr %0, i64 72
   %733 = load ptr, ptr %732, align 8, !tbaa !43, !noalias !453
   %.not.i.i.i.i.i428 = icmp eq ptr %733, null
@@ -12656,8 +12655,7 @@ _ZNSt13_Bvector_baseISaIbEED2Ev.exit600:          ; preds = %_ZNSt6vectorIfSaIfE
   call void @llvm.experimental.noalias.scope.decl(metadata !495)
   %1297 = load ptr, ptr %1296, align 8, !tbaa !428, !noalias !498, !nonnull !102, !noundef !102
   %1298 = call ptr @__dynamic_cast(ptr nonnull %1297, ptr nonnull @_ZTIN2cv4usac10DegeneracyE, ptr nonnull @_ZTIN2cv4usac21FundamentalDegeneracyE, i64 0) #28, !noalias !498
-  %.not.not.i.i601 = icmp ne ptr %1298, null
-  call void @llvm.assume(i1 %.not.not.i.i601)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1298) ]
   %1299 = getelementptr inbounds nuw i8, ptr %0, i64 120
   %1300 = load ptr, ptr %1299, align 8, !tbaa !43, !noalias !498
   %.not.i.i.i.i.i602 = icmp eq ptr %1300, null
@@ -22933,8 +22931,7 @@ _ZNSt7__cxx1112basic_stringIcSt11char_traitsIcESaIcEED2Ev.exit880: ; preds = %33
   call void @llvm.experimental.noalias.scope.decl(metadata !642)
   %3374 = load ptr, ptr %3373, align 8, !tbaa !645, !noalias !646, !nonnull !102, !noundef !102
   %3375 = call ptr @__dynamic_cast(ptr nonnull %3374, ptr nonnull @_ZTIN2cv4usac11TerminationE, ptr nonnull @_ZTIN2cv4usac25ProsacTerminationCriteriaE, i64 0) #28, !noalias !646
-  %.not.not.i.i = icmp ne ptr %3375, null
-  call void @llvm.assume(i1 %.not.not.i.i)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3375) ]
   %3376 = getelementptr inbounds nuw i8, ptr %0, i64 88
   %3377 = load ptr, ptr %3376, align 8, !tbaa !43, !noalias !646
   %.not.i.i.i.i.i881 = icmp eq ptr %3377, null
@@ -32845,8 +32842,7 @@ _ZNSt6vectorIS_IiSaIiEESaIS1_EE12emplace_backIJRS1_EEEvDpOT_.exit: ; preds = %11
   call void @llvm.experimental.noalias.scope.decl(metadata !841)
   %161 = load ptr, ptr %160, align 8, !tbaa !645, !noalias !844, !nonnull !102, !noundef !102
   %162 = call ptr @__dynamic_cast(ptr nonnull %161, ptr nonnull @_ZTIN2cv4usac11TerminationE, ptr nonnull @_ZTIN2cv4usac25ProsacTerminationCriteriaE, i64 0) #28, !noalias !844
-  %.not.not.i.i = icmp ne ptr %162, null
-  call void @llvm.assume(i1 %.not.not.i.i)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %162) ]
   %163 = getelementptr inbounds nuw i8, ptr %160, i64 8
   %164 = load ptr, ptr %163, align 8, !tbaa !43, !noalias !844
   %.not.i.i.i.i.i = icmp eq ptr %164, null
diff --git a/bench/openssl/optimized/ml_kem_codecs.ll b/bench/openssl/optimized/ml_kem_codecs.ll
index 7d805530b52..1e9f090a3d5 100644
--- a/bench/openssl/optimized/ml_kem_codecs.ll
+++ b/bench/openssl/optimized/ml_kem_codecs.ll
@@ -465,7 +465,7 @@ declare void @CRYPTO_free(ptr noundef, ptr noundef, i32 noundef) local_unnamed_a
 declare void @PKCS8_PRIV_KEY_INFO_free(ptr noundef) local_unnamed_addr #1
 
 ; Function Attrs: nounwind uwtable
-define noundef i32 @ossl_ml_kem_i2d_pubkey(ptr noundef %0, ptr noundef captures(address_is_null) %1) local_unnamed_addr #0 {
+define noundef i32 @ossl_ml_kem_i2d_pubkey(ptr noundef %0, ptr noundef captures(none) %1) local_unnamed_addr #0 {
   %3 = getelementptr inbounds nuw i8, ptr %0, i64 64
   %4 = load ptr, ptr %3, align 8, !tbaa !48
   %.not = icmp eq ptr %4, null
@@ -483,8 +483,7 @@ define noundef i32 @ossl_ml_kem_i2d_pubkey(ptr noundef %0, ptr noundef captures(
   %9 = load ptr, ptr %0, align 8, !tbaa !49
   %10 = getelementptr inbounds nuw i8, ptr %9, i64 24
   %11 = load i64, ptr %10, align 8, !tbaa !3
-  %.not13 = icmp ne ptr %1, null
-  tail call void @llvm.assume(i1 %.not13)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %12 = tail call noalias ptr @CRYPTO_malloc(i64 noundef %11, ptr noundef nonnull @.str, i32 noundef 293) #7
   store ptr %12, ptr %1, align 8, !tbaa !14
   %13 = icmp eq ptr %12, null
diff --git a/bench/openssl/optimized/quic_impl.ll b/bench/openssl/optimized/quic_impl.ll
index c4ed02d04d4..819cb33d471 100644
--- a/bench/openssl/optimized/quic_impl.ll
+++ b/bench/openssl/optimized/quic_impl.ll
@@ -7487,7 +7487,7 @@ ql_listen.exit:                                   ; preds = %qctx_lock_for_io.ex
   %50 = call ptr @ossl_quic_engine_get0_reactor(ptr noundef %.val32.val) #12
   %51 = call i32 @ossl_quic_reactor_block_until_pred(ptr noundef %50, ptr noundef nonnull @quic_accept_connection_wait, ptr noundef %48, i32 noundef 0) #12
   %52 = icmp slt i32 %51, 1
-  br i1 %52, label %110, label %qctx_maybe_autotick.exit
+  br i1 %52, label %109, label %qctx_maybe_autotick.exit
 
 53:                                               ; preds = %43, %42
   %.val31 = load ptr, ptr %3, align 8, !tbaa !157
@@ -7523,7 +7523,7 @@ qctx_maybe_autotick.exit:                         ; preds = %54, %qctx_should_au
   %67 = load ptr, ptr %66, align 8, !tbaa !139
   %68 = call i32 @ossl_quic_port_is_running(ptr noundef %67) #12
   %.not28 = icmp eq i32 %68, 0
-  br i1 %.not28, label %110, label %69
+  br i1 %.not28, label %109, label %69
 
 69:                                               ; preds = %qctx_maybe_autotick.exit
   %70 = load ptr, ptr %22, align 8, !tbaa !163
@@ -7552,47 +7552,46 @@ qctx_maybe_autotick.exit:                         ; preds = %54, %qctx_should_au
   %87 = load ptr, ptr %86, align 8, !tbaa !139
   %88 = call ptr @ossl_quic_port_pop_incoming(ptr noundef %87) #12
   %89 = icmp eq ptr %88, null
-  br i1 %89, label %110, label %.thread35
+  br i1 %89, label %109, label %.thread35
 
 .thread35:                                        ; preds = %ql_listen.exit, %79, %.thread, %69
   %.1 = phi ptr [ %88, %79 ], [ null, %.thread ], [ %73, %69 ], [ %35, %ql_listen.exit ]
   %90 = call ptr @ossl_quic_channel_get0_tls(ptr noundef %.1) #12
-  %91 = icmp ne ptr %90, null
-  call void @llvm.assume(i1 %91)
-  %92 = load i32, ptr %90, align 8, !tbaa !31
-  %93 = icmp eq i32 %92, 0
-  br i1 %93, label %98, label %94
-
-94:                                               ; preds = %.thread35
-  %95 = and i32 %92, 128
-  %96 = icmp ne i32 %95, 0
-  call void @llvm.assume(i1 %96)
-  %97 = call ptr @ossl_quic_obj_get0_handshake_layer(ptr noundef nonnull %90) #12
-  br label %98
-
-98:                                               ; preds = %.thread35, %94
-  %99 = phi ptr [ %97, %94 ], [ %90, %.thread35 ]
-  %100 = getelementptr inbounds nuw i8, ptr %99, i64 64
-  %101 = load ptr, ptr %100, align 8, !tbaa !235
-  %102 = load ptr, ptr %22, align 8, !tbaa !163
-  %103 = getelementptr inbounds nuw i8, ptr %101, i64 128
-  store ptr %102, ptr %103, align 8, !tbaa !135
-  %104 = getelementptr inbounds nuw i8, ptr %101, i64 336
-  %105 = load i16, ptr %104, align 8
-  %106 = and i16 %105, -513
-  store i16 %106, ptr %104, align 8
-  %107 = call i32 @SSL_up_ref(ptr noundef %102) #12
-  %.not30 = icmp eq i32 %107, 0
-  br i1 %.not30, label %108, label %110
-
-108:                                              ; preds = %98
-  call void @SSL_free(ptr noundef nonnull %101) #12
-  %109 = call ptr @ossl_quic_channel_get0_tls(ptr noundef %.1) #12
-  call void @SSL_free(ptr noundef %109) #12
-  br label %110
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %90) ]
+  %91 = load i32, ptr %90, align 8, !tbaa !31
+  %92 = icmp eq i32 %91, 0
+  br i1 %92, label %110, label %93
+
+93:                                               ; preds = %.thread35
+  %94 = and i32 %91, 128
+  %95 = icmp ne i32 %94, 0
+  call void @llvm.assume(i1 %95)
+  %96 = call ptr @ossl_quic_obj_get0_handshake_layer(ptr noundef nonnull %90) #12
+  br label %97
 
-110:                                              ; preds = %98, %108, %79, %qctx_maybe_autotick.exit, %45
-  %.019 = phi ptr [ null, %79 ], [ %101, %98 ], [ null, %108 ], [ null, %qctx_maybe_autotick.exit ], [ null, %45 ]
+110:                                              ; preds = %.thread35, %93
+  %.019 = phi ptr [ %96, %93 ], [ %90, %.thread35 ]
+  %99 = getelementptr inbounds nuw i8, ptr %98, i64 64
+  %100 = load ptr, ptr %99, align 8, !tbaa !235
+  %101 = load ptr, ptr %22, align 8, !tbaa !163
+  %102 = getelementptr inbounds nuw i8, ptr %100, i64 128
+  store ptr %101, ptr %102, align 8, !tbaa !135
+  %103 = getelementptr inbounds nuw i8, ptr %100, i64 336
+  %104 = load i16, ptr %103, align 8
+  %105 = and i16 %104, -513
+  store i16 %105, ptr %103, align 8
+  %106 = call i32 @SSL_up_ref(ptr noundef %101) #12
+  %.not30 = icmp eq i32 %106, 0
+  br i1 %.not30, label %107, label %109
+
+107:                                              ; preds = %97
+  call void @SSL_free(ptr noundef nonnull %100) #12
+  %108 = call ptr @ossl_quic_channel_get0_tls(ptr noundef %.1) #12
+  call void @SSL_free(ptr noundef %108) #12
+  br label %109
+
+109:                                              ; preds = %97, %107, %79, %qctx_maybe_autotick.exit, %45
+  %.019 = phi ptr [ null, %79 ], [ %100, %97 ], [ null, %107 ], [ null, %qctx_maybe_autotick.exit ], [ null, %45 ]
   %.val33 = load ptr, ptr %3, align 8, !tbaa !157
   %111 = getelementptr i8, ptr %.val33, i64 88
   %.val33.val = load ptr, ptr %111, align 8, !tbaa !143
@@ -7600,8 +7599,8 @@ qctx_maybe_autotick.exit:                         ; preds = %54, %qctx_should_au
   call void @ossl_crypto_mutex_unlock(ptr noundef %112) #12
   br label %113
 
-113:                                              ; preds = %2, %110
-  %.0 = phi ptr [ %.019, %110 ], [ null, %2 ]
+113:                                              ; preds = %2, %109
+  %.0 = phi ptr [ %.019, %109 ], [ null, %2 ]
   call void @llvm.lifetime.end.p0(ptr nonnull %3)
   ret ptr %.0
 }
diff --git a/bench/openssl/optimized/quic_tls_api.ll b/bench/openssl/optimized/quic_tls_api.ll
index 297f24aa657..bd3f23b60a8 100644
--- a/bench/openssl/optimized/quic_tls_api.ll
+++ b/bench/openssl/optimized/quic_tls_api.ll
@@ -449,21 +449,20 @@ declare i32 @ossl_quic_tls_configure(ptr noundef) local_unnamed_addr #1
 
 ; Function Attrs: nounwind uwtable
 define i32 @SSL_set_quic_tls_transport_params(ptr noundef %0, ptr noundef %1, i64 noundef %2) local_unnamed_addr #0 {
-  %4 = icmp ne ptr %0, null
-  tail call void @llvm.assume(i1 %4)
-  %5 = load i32, ptr %0, align 8, !tbaa !3
-  %6 = icmp eq i32 %5, 0
-  br i1 %6, label %10, label %7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
+  %4 = load i32, ptr %0, align 8, !tbaa !3
+  %5 = icmp eq i32 %4, 0
+  br i1 %5, label %10, label %6
 
 7:                                                ; preds = %3
-  %8 = and i32 %5, 128
+  %8 = and i32 %4, 128
   %.not = icmp ne i32 %8, 0
   tail call void @llvm.assume(i1 %.not)
   %9 = tail call ptr @ossl_quic_obj_get0_handshake_layer(ptr noundef nonnull %0) #5
   br label %10
 
 10:                                               ; preds = %3, %7
-  %11 = phi ptr [ %0, %3 ], [ %9, %7 ]
+  %11 = phi ptr [ %0, %3 ], [ %9, %6 ]
   %12 = getelementptr inbounds nuw i8, ptr %11, i64 344
   %13 = load ptr, ptr %12, align 8, !tbaa !81
   %14 = icmp eq ptr %13, null
@@ -480,7 +479,7 @@ define i32 @SSL_set_quic_tls_transport_params(ptr noundef %0, ptr noundef %1, i6
   br label %18
 
 18:                                               ; preds = %16, %15
-  %.0 = phi i32 [ 0, %15 ], [ %17, %16 ]
+  %.0 = phi i32 [ 0, %14 ], [ %17, %15 ]
   ret i32 %.0
 }
 
diff --git a/bench/openusd/optimized/testHdDataSource.ll b/bench/openusd/optimized/testHdDataSource.ll
index 1c0caee952e..66fcaa6c043 100644
--- a/bench/openusd/optimized/testHdDataSource.ll
+++ b/bench/openusd/optimized/testHdDataSource.ll
@@ -14408,8 +14408,7 @@ define dso_local noundef zeroext i1 @_Z33TestRetainedSmallVectorDataSourcev() lo
   call void @llvm.experimental.noalias.scope.decl(metadata !42)
   %74 = load ptr, ptr %9, align 8, !noalias !45, !nonnull !46, !noundef !46
   %75 = call ptr @__dynamic_cast(ptr nonnull %74, ptr nonnull @_ZTIN32pxrInternal_v0_24__pxrReserved__16HdDataSourceBaseE, ptr nonnull @_ZTIN32pxrInternal_v0_24__pxrReserved__32HdRetainedTypedSampledDataSourceIiEE, i64 0) #22, !noalias !45
-  %.not.i.i = icmp ne ptr %75, null
-  call void @llvm.assume(i1 %.not.i.i)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %75) ]
   store ptr %75, ptr %12, align 8, !alias.scope !45
   %76 = getelementptr inbounds nuw i8, ptr %12, i64 8
   %77 = getelementptr inbounds nuw i8, ptr %9, i64 8
@@ -14452,8 +14451,7 @@ _ZN32pxrInternal_v0_24__pxrReserved__32HdRetainedTypedSampledDataSourceIiE4CastE
   call void @llvm.experimental.noalias.scope.decl(metadata !50)
   %94 = load ptr, ptr %10, align 8, !noalias !53, !nonnull !46, !noundef !46
   %95 = call ptr @__dynamic_cast(ptr nonnull %94, ptr nonnull @_ZTIN32pxrInternal_v0_24__pxrReserved__16HdDataSourceBaseE, ptr nonnull @_ZTIN32pxrInternal_v0_24__pxrReserved__32HdRetainedTypedSampledDataSourceIiEE, i64 0) #22, !noalias !53
-  %.not.i.i43 = icmp ne ptr %95, null
-  call void @llvm.assume(i1 %.not.i.i43)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %95) ]
   store ptr %95, ptr %13, align 8, !alias.scope !53
   %96 = getelementptr inbounds nuw i8, ptr %13, i64 8
   %97 = getelementptr inbounds nuw i8, ptr %10, i64 8
@@ -14496,8 +14494,7 @@ _ZN32pxrInternal_v0_24__pxrReserved__32HdRetainedTypedSampledDataSourceIiE4CastE
   call void @llvm.experimental.noalias.scope.decl(metadata !57)
   %114 = load ptr, ptr %11, align 8, !noalias !60, !nonnull !46, !noundef !46
   %115 = call ptr @__dynamic_cast(ptr nonnull %114, ptr nonnull @_ZTIN32pxrInternal_v0_24__pxrReserved__16HdDataSourceBaseE, ptr nonnull @_ZTIN32pxrInternal_v0_24__pxrReserved__32HdRetainedTypedSampledDataSourceIiEE, i64 0) #22, !noalias !60
-  %.not.i.i48 = icmp ne ptr %115, null
-  call void @llvm.assume(i1 %.not.i.i48)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %115) ]
   store ptr %115, ptr %14, align 8, !alias.scope !60
   %116 = getelementptr inbounds nuw i8, ptr %14, i64 8
   %117 = getelementptr inbounds nuw i8, ptr %11, i64 8
diff --git a/bench/pingora-rs/optimized/9ivpbe6von87vkj0l3ykagsem.ll b/bench/pingora-rs/optimized/9ivpbe6von87vkj0l3ykagsem.ll
index 865c308d8a3..9418d0f8803 100644
--- a/bench/pingora-rs/optimized/9ivpbe6von87vkj0l3ykagsem.ll
+++ b/bench/pingora-rs/optimized/9ivpbe6von87vkj0l3ykagsem.ll
@@ -133,6 +133,7 @@ define hidden { i64, ptr } @_ZN5tokio2io11async_write10AsyncWrite19poll_write_ve
 
 9:                                                ; preds = %6
   %10 = getelementptr inbounds nuw i8, ptr %7, i64 16
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %7) ]
   %11 = getelementptr i8, ptr %7, i64 8
   %12 = load i64, ptr %11, align 8, !noalias !9, !noundef !8
   %.not.i = icmp eq i64 %12, 0
@@ -145,10 +146,9 @@ define hidden { i64, ptr } @_ZN5tokio2io11async_write10AsyncWrite19poll_write_ve
 "_ZN4core6option15Option$LT$T$GT$6map_or17h1a055a8159305d80E.exit": ; preds = %6, %13
   %.sroa.3.0.i = phi i64 [ %12, %13 ], [ 0, %6 ]
   %.sroa.02.0.i = phi ptr [ %.val.i, %13 ], [ inttoptr (i64 1 to ptr), %6 ]
-  %14 = icmp ne ptr %.sroa.02.0.i, null
-  tail call void @llvm.assume(i1 %14)
-  %15 = tail call { i64, ptr } @"_ZN89_$LT$pingora_proxy..subrequest..DummyIO$u20$as$u20$tokio..io..async_write..AsyncWrite$GT$10poll_write17hf05cd47417d7183cE"(ptr noalias noundef nonnull align 8 dereferenceable(32) %0, ptr noalias noundef nonnull align 8 dereferenceable(32) %1, ptr noalias noundef nonnull readonly align 1 %.sroa.02.0.i, i64 noundef %.sroa.3.0.i)
-  ret { i64, ptr } %15
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.02.0.i) ]
+  %14 = tail call { i64, ptr } @"_ZN89_$LT$pingora_proxy..subrequest..DummyIO$u20$as$u20$tokio..io..async_write..AsyncWrite$GT$10poll_write17hf05cd47417d7183cE"(ptr noalias noundef nonnull align 8 dereferenceable(32) %0, ptr noalias noundef nonnull align 8 dereferenceable(32) %1, ptr noalias noundef nonnull readonly align 1 %.sroa.02.0.i, i64 noundef %.sroa.3.0.i)
+  ret { i64, ptr } %14
 }
 
 ; Function Attrs: nonlazybind uwtable
@@ -177,6 +177,7 @@ define hidden noundef nonnull ptr @"_ZN5tokio4sync4mpsc5block14Block$LT$T$GT$4gr
   br i1 %13, label %.loopexit, label %.preheader
 
 .preheader:                                       ; preds = %"_ZN5tokio4sync4mpsc5block14Block$LT$T$GT$3new17h5b8de3a0a9a5239bE.exit"
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %5) ]
   %14 = getelementptr inbounds nuw i8, ptr %12, i64 6656
   %15 = load i64, ptr %14, align 8, !noundef !8
   %16 = add i64 %15, 32
diff --git a/bench/pola-rs/optimized/0vv5nrmroubc6gns0tdninfa0.ll b/bench/pola-rs/optimized/0vv5nrmroubc6gns0tdninfa0.ll
index 5f4b93fd241..673f8199cb7 100644
--- a/bench/pola-rs/optimized/0vv5nrmroubc6gns0tdninfa0.ll
+++ b/bench/pola-rs/optimized/0vv5nrmroubc6gns0tdninfa0.ll
@@ -21,6 +21,7 @@ define internal void @"_ZN3std4sync6poison4once4Once15call_once_force28_$u7b$$u7
   br i1 %.not, label %12, label %4, !prof !5
 
 4:                                                ; preds = %2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.0.copyload) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !6)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !9)
   %5 = load ptr, ptr %.sroa.0.0.copyload, align 8, !alias.scope !12, !noundef !3
@@ -35,10 +36,8 @@ define internal void @"_ZN3std4sync6poison4once4Once15call_once_force28_$u7b$$u7
   unreachable
 
 "_ZN3std4sync9once_lock17OnceLock$LT$T$GT$10initialize28_$u7b$$u7b$closure$u7d$$u7d$17hc48fc75216420739E.exit": ; preds = %4
-  %9 = icmp ne ptr %7, null
-  tail call void @llvm.assume(i1 %9)
-  %10 = icmp ne ptr %.sroa.5.sroa.0.0.copyload, null
-  tail call void @llvm.assume(i1 %10)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %7) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.5.sroa.0.0.copyload) ]
   store ptr %5, ptr %.sroa.5.sroa.0.0.copyload, align 8
   %11 = getelementptr inbounds nuw i8, ptr %.sroa.5.sroa.0.0.copyload, i64 8
   store ptr %7, ptr %11, align 8
@@ -89,6 +88,7 @@ define internal void @"_ZN4core3ops8function6FnOnce40call_once$u7b$$u7b$vtable.s
   br i1 %.not.i.i, label %9, label %4, !prof !5
 
 4:                                                ; preds = %2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.0.copyload.i.i) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !23)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !26)
   %5 = load ptr, ptr %.sroa.0.0.copyload.i.i, align 8, !alias.scope !29, !noalias !30, !noundef !3
@@ -107,10 +107,8 @@ define internal void @"_ZN4core3ops8function6FnOnce40call_once$u7b$$u7b$vtable.s
   unreachable
 
 _ZN4core3ops8function6FnOnce9call_once17h056f857c880df310E.exit: ; preds = %4
-  %10 = icmp ne ptr %7, null
-  tail call void @llvm.assume(i1 %10)
-  %11 = icmp ne ptr %.sroa.5.sroa.0.0.copyload.i.i, null
-  tail call void @llvm.assume(i1 %11)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %7) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.5.sroa.0.0.copyload.i.i) ]
   store ptr %5, ptr %.sroa.5.sroa.0.0.copyload.i.i, align 8, !noalias !30
   %12 = getelementptr inbounds nuw i8, ptr %.sroa.5.sroa.0.0.copyload.i.i, i64 8
   store ptr %7, ptr %12, align 8, !noalias !30
diff --git a/bench/pola-rs/optimized/5529vdmdygdg4sx1xlpwmczeg.ll b/bench/pola-rs/optimized/5529vdmdygdg4sx1xlpwmczeg.ll
index 773a0064233..5c4ef8a6b9b 100644
--- a/bench/pola-rs/optimized/5529vdmdygdg4sx1xlpwmczeg.ll
+++ b/bench/pola-rs/optimized/5529vdmdygdg4sx1xlpwmczeg.ll
@@ -21,6 +21,7 @@ target triple = "x86_64-unknown-linux-gnu"
 ; Function Attrs: nonlazybind uwtable
 define hidden noundef ptr @"_ZN3std6thread5local17LocalKey$LT$T$GT$4with17h334be6ccbd10af4cE"(ptr noalias noundef readonly align 8 captures(none) dereferenceable(8) %0) unnamed_addr #0 personality ptr @rust_eh_personality {
   %.val = load ptr, ptr %0, align 8, !nonnull !3, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %2 = tail call noundef ptr %.val(ptr noalias noundef align 8 dereferenceable_or_null(16) null)
   %3 = icmp eq ptr %2, null
   br i1 %3, label %4, label %5
@@ -40,6 +41,7 @@ define hidden void @"_ZN3std6thread5local17LocalKey$LT$T$GT$4with17h77173e52ce54
   %4 = alloca [136 x i8], align 8
   %.val = load ptr, ptr %0, align 8, !nonnull !3, !noundef !3
   tail call void @llvm.experimental.noalias.scope.decl(metadata !4)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = tail call noundef ptr %.val(ptr noalias noundef align 4 dereferenceable_or_null(16) null), !noalias !4
   %6 = icmp eq ptr %5, null
   br i1 %6, label %16, label %7
@@ -95,6 +97,7 @@ define hidden void @"_ZN3std6thread5local17LocalKey$LT$T$GT$4with17hb1e965b06dc0
   %4 = alloca [64 x i8], align 8
   %.val = load ptr, ptr %0, align 8, !nonnull !3, !noundef !3
   tail call void @llvm.experimental.noalias.scope.decl(metadata !10)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = tail call noundef ptr %.val(ptr noalias noundef align 4 dereferenceable_or_null(16) null), !noalias !10
   %6 = icmp eq ptr %5, null
   br i1 %6, label %16, label %7
@@ -149,6 +152,7 @@ define hidden void @"_ZN3std6thread5local17LocalKey$LT$T$GT$4with17heaed4184b911
   %5 = alloca [24 x i8], align 8
   %6 = alloca [16 x i8], align 8
   %.val = load ptr, ptr %1, align 8, !nonnull !3, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %7 = tail call noundef ptr %.val(ptr noalias noundef align 8 dereferenceable_or_null(128) null), !noalias !16
   %8 = icmp eq ptr %7, null
   br i1 %8, label %39, label %9
@@ -442,6 +446,8 @@ define hidden void @"_ZN5alloc3vec16in_place_collect108_$LT$impl$u20$alloc..vec.
   %.val.i.i = load ptr, ptr %9, align 8, !alias.scope !56, !noalias !57, !nonnull !3, !noundef !3
   %10 = getelementptr inbounds nuw i8, ptr %1, i64 24
   %.val3.i.i = load ptr, ptr %10, align 8, !alias.scope !56, !noalias !57, !nonnull !3, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3.i.i) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i.i) ]
   %11 = ptrtoint ptr %.val3.i.i to i64
   %12 = ptrtoint ptr %.val.i.i to i64
   %13 = sub nuw i64 %11, %12
@@ -486,6 +492,8 @@ define hidden void @"_ZN5alloc3vec16in_place_collect108_$LT$impl$u20$alloc..vec.
   %.val.i.i.i.i = load ptr, ptr %27, align 8, !alias.scope !73, !noalias !74, !nonnull !3, !noundef !3
   %28 = getelementptr inbounds nuw i8, ptr %7, i64 24
   %.val3.i.i.i.i = load ptr, ptr %28, align 8, !alias.scope !73, !noalias !74, !nonnull !3, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3.i.i.i.i) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i.i.i.i) ]
   %29 = ptrtoint ptr %.val3.i.i.i.i to i64
   %30 = ptrtoint ptr %.val.i.i.i.i to i64
   %31 = sub nuw i64 %29, %30
@@ -630,6 +638,7 @@ define hidden void @"_ZN61_$LT$$u5b$V$u5d$$u20$as$u20$alloc..slice..Concat$LT$T$
   %.val = load ptr, ptr %.sroa.0.010, align 8, !nonnull !3, !align !86, !noundef !3
   %28 = getelementptr i8, ptr %.sroa.0.010, i64 8
   %.val6 = load i64, ptr %28, align 8, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %29 = load i64, ptr %5, align 8, !range !34, !alias.scope !87, !noundef !3
   %30 = sub i64 %29, %26
   %31 = icmp ugt i64 %.val6, %30
@@ -963,6 +972,7 @@ define hidden noundef align 8 dereferenceable_or_null(72) ptr @"_ZN7slotmap5basi
   %13 = load ptr, ptr %12, align 8, !nonnull !3
   %14 = getelementptr inbounds nuw { { [9 x i64] }, i32, [1 x i32] }, ptr %13, i64 %10
   %15 = extractvalue { i32, i32 } %6, 0
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %14) ]
   %16 = getelementptr inbounds nuw i8, ptr %14, i64 72
   %17 = load i32, ptr %16, align 8, !alias.scope !115, !noundef !3
   %18 = icmp eq i32 %17, %15
@@ -996,6 +1006,7 @@ define hidden noundef nonnull align 8 dereferenceable(72) ptr @"_ZN89_$LT$slotma
 13:                                               ; preds = %4
   %14 = getelementptr inbounds nuw { { [9 x i64] }, i32, [1 x i32] }, ptr %.val, i64 %11
   %15 = extractvalue { i32, i32 } %9, 0
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %14) ]
   %16 = getelementptr inbounds nuw i8, ptr %14, i64 72
   %17 = load i32, ptr %16, align 8, !alias.scope !118, !noundef !3
   %18 = icmp eq i32 %17, %15
@@ -1032,6 +1043,7 @@ define hidden noundef nonnull align 8 dereferenceable(72) ptr @"_ZN92_$LT$slotma
   %14 = load ptr, ptr %13, align 8, !alias.scope !121, !nonnull !3
   %15 = getelementptr inbounds nuw { { [9 x i64] }, i32, [1 x i32] }, ptr %14, i64 %11
   %16 = extractvalue { i32, i32 } %7, 0
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %15) ]
   %17 = getelementptr inbounds nuw i8, ptr %15, i64 72
   %18 = load i32, ptr %17, align 8, !alias.scope !124, !noalias !121, !noundef !3
   %19 = icmp eq i32 %18, %16
diff --git a/bench/pola-rs/optimized/5ery43j47n3swq9jsoogxo0r0.ll b/bench/pola-rs/optimized/5ery43j47n3swq9jsoogxo0r0.ll
index 8df5d8d26bb..3c371bf7f2f 100644
--- a/bench/pola-rs/optimized/5ery43j47n3swq9jsoogxo0r0.ll
+++ b/bench/pola-rs/optimized/5ery43j47n3swq9jsoogxo0r0.ll
@@ -81,30 +81,29 @@ target triple = "x86_64-unknown-linux-gnu"
 
 ; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(argmem: read, inaccessiblemem: write) uwtable
 define hidden noundef i32 @"_ZN104_$LT$core..iter..adapters..copied..Copied$LT$I$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h35768d8aae598695E"(ptr noundef nonnull %0, ptr noundef %1, i32 noundef %2) unnamed_addr #0 personality ptr @rust_eh_personality {
-  %4 = icmp ne ptr %1, null
-  tail call void @llvm.assume(i1 %4)
-  %5 = icmp eq ptr %0, %1
-  br i1 %5, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h68279598991a4ca2E.exit", label %6
-
-6:                                                ; preds = %3
-  %7 = ptrtoint ptr %1 to i64
-  %8 = ptrtoint ptr %0 to i64
-  %9 = sub nuw i64 %7, %8
-  %10 = lshr exact i64 %9, 2
-  br label %11
-
-11:                                               ; preds = %11, %6
-  %.sroa.07.0.i = phi i32 [ %2, %6 ], [ %.sroa.0.0.i.sroa.speculated.i.i.i, %11 ]
-  %.sroa.09.0.i = phi i64 [ 0, %6 ], [ %13, %11 ]
-  %12 = getelementptr inbounds nuw i32, ptr %0, i64 %.sroa.09.0.i
-  %.val.i = load i32, ptr %12, align 4, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
+  %4 = icmp eq ptr %0, %1
+  br i1 %4, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h68279598991a4ca2E.exit", label %5
+
+5:                                                ; preds = %3
+  %6 = ptrtoint ptr %1 to i64
+  %7 = ptrtoint ptr %0 to i64
+  %8 = sub nuw i64 %6, %7
+  %9 = lshr exact i64 %8, 2
+  br label %10
+
+10:                                               ; preds = %10, %5
+  %.sroa.07.0.i = phi i32 [ %2, %5 ], [ %.sroa.0.0.i.sroa.speculated.i.i.i, %10 ]
+  %.sroa.07.0.i = phi i64 [ 0, %5 ], [ %12, %10 ]
+  %11 = getelementptr inbounds nuw i32, ptr %0, i64 %.sroa.09.0.i
+  %.val.i = load i32, ptr %11, align 4, !noundef !3
   %.sroa.0.0.i.sroa.speculated.i.i.i = tail call noundef i32 @llvm.umax.i32(i32 %.sroa.07.0.i, i32 %.val.i)
   %13 = add nuw i64 %.sroa.09.0.i, 1
-  %14 = icmp eq i64 %13, %10
-  br i1 %14, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h68279598991a4ca2E.exit", label %11
+  %14 = icmp eq i64 %13, %9
+  br i1 %14, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h68279598991a4ca2E.exit", label %10
 
-"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h68279598991a4ca2E.exit": ; preds = %11, %3
-  %.sroa.04.0.i = phi i32 [ %2, %3 ], [ %.sroa.0.0.i.sroa.speculated.i.i.i, %11 ]
+"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h68279598991a4ca2E.exit": ; preds = %10, %3
+  %.sroa.04.0.i = phi i32 [ %2, %3 ], [ %.sroa.0.0.i.sroa.speculated.i.i.i, %10 ]
   ret i32 %.sroa.04.0.i
 }
 
@@ -149,6 +148,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %.val = load ptr, ptr %3, align 8, !nonnull !3, !align !8, !noundef !3
   %4 = getelementptr i8, ptr %3, i64 8
   %.val1 = load i64, ptr %4, align 8, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = tail call noundef zeroext i1 @"_ZN40_$LT$str$u20$as$u20$core..fmt..Debug$GT$3fmt17hcf6a5cb102847ddcE"(ptr noalias noundef nonnull readonly align 1 %.val, i64 noundef %.val1, ptr noalias noundef nonnull align 8 dereferenceable(24) %1)
   ret i1 %5
 }
@@ -343,11 +343,13 @@ define internal void @"_ZN4core3ptr71drop_in_place$LT$alloc..boxed..Box$LT$polar
   br label %31
 
 "_ZN4core3ptr46drop_in_place$LT$polars_error..PolarsError$GT$17h9d30786684d9210fE.exit": ; preds = %.invoke, %5, %"_ZN4core3ptr66drop_in_place$LT$alloc..sync..Arc$LT$std..io..error..Error$GT$$GT$17haa627bd948fa0910E.exit"
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   tail call void @_RNvCsjH7bwORMyv9_7___rustc14___rust_dealloc(ptr noundef nonnull %2, i64 noundef 64, i64 noundef 8) #15
   ret void
 
 31:                                               ; preds = %29, %12, %17, %24
   %eh.lpad-body = phi { ptr, i32 } [ %30, %29 ], [ %25, %24 ], [ %13, %17 ], [ %13, %12 ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   tail call void @_RNvCsjH7bwORMyv9_7___rustc14___rust_dealloc(ptr noundef nonnull %2, i64 noundef 64, i64 noundef 8) #15
   resume { ptr, i32 } %eh.lpad-body
 }
@@ -421,12 +423,14 @@ define internal void @"_ZN4core3ptr85drop_in_place$LT$alloc..boxed..Box$LT$polar
           to label %"_ZN4core3ptr60drop_in_place$LT$polars_core..datatypes..dtype..DataType$GT$17h14f360565a6e873aE.exit" unwind label %29
 
 "_ZN4core3ptr60drop_in_place$LT$polars_core..datatypes..dtype..DataType$GT$17h14f360565a6e873aE.exit": ; preds = %.invoke12, %.invoke, %1, %4, %8, %16, %12, %23, %19, %27
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   tail call void @_RNvCsjH7bwORMyv9_7___rustc14___rust_dealloc(ptr noundef nonnull %2, i64 noundef 48, i64 noundef 16) #15
   ret void
 
 29:                                               ; preds = %.invoke12, %.invoke, %27, %8
   %30 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   tail call void @_RNvCsjH7bwORMyv9_7___rustc14___rust_dealloc(ptr noundef nonnull %2, i64 noundef 48, i64 noundef 16) #15
   resume { ptr, i32 } %30
 }
diff --git a/bench/proxygen/optimized/Huffman.ll b/bench/proxygen/optimized/Huffman.ll
index 77131495044..230ed45680a 100644
--- a/bench/proxygen/optimized/Huffman.ll
+++ b/bench/proxygen/optimized/Huffman.ll
@@ -644,12 +644,7 @@ if.else:                                          ; preds = %for.body
   %sub.ptr.rhs.cast.i.i.i.i = ptrtoint ptr %7 to i64
   %sub.ptr.sub.i.i.i.i = sub i64 %sub.ptr.lhs.cast.i.i.i.i, %sub.ptr.rhs.cast.i.i.i.i
   %cmp.i.i = icmp ugt i64 %sub.ptr.sub.i.i.i.i, 3
-  br i1 %cmp.i.i, label %if.then.i.i, label %if.else.i.i
-
-if.then.i.i:                                      ; preds = %if.else
-  %cmp.i.i.i = icmp ne ptr %7, null
-  tail call void @llvm.assume(i1 %cmp.i.i.i)
-  br label %_ZN5folly2io6detail8WritableINS0_13QueueAppenderEE7writeBEIjEEvT_.exit
+  br i1 %cmp.i.i, label %_ZN5folly2io6detail8WritableINS0_13QueueAppenderEE7writeBEIjEEvT_.exit, label %if.else.i.i
 
 if.else.i.i:                                      ; preds = %if.else
   %8 = load ptr, ptr %queue_.i.i.i.i, align 8
@@ -698,13 +693,14 @@ if.then.i.i.i.i.i:                                ; preds = %_ZN5folly10IOBufQue
   br label %_ZN5folly2io13QueueAppender9writeSlowIjEENSt9enable_ifIXsr3std13is_arithmeticIT_EE5valueEvE4typeES4_m.exit.i.i
 
 _ZN5folly2io13QueueAppender9writeSlowIjEENSt9enable_ifIXsr3std13is_arithmeticIT_EE5valueEvE4typeES4_m.exit.i.i: ; preds = %if.then.i.i.i.i.i, %_ZN5folly10IOBufQueue11preallocateEmmm.exit.i.i.i
-  %18 = load ptr, ptr %buf, align 8, !nonnull !8, !noundef !8
+  %18 = load ptr, ptr %buf, align 8
   br label %_ZN5folly2io6detail8WritableINS0_13QueueAppenderEE7writeBEIjEEvT_.exit
 
-_ZN5folly2io6detail8WritableINS0_13QueueAppenderEE7writeBEIjEEvT_.exit: ; preds = %if.then.i.i, %_ZN5folly2io13QueueAppender9writeSlowIjEENSt9enable_ifIXsr3std13is_arithmeticIT_EE5valueEvE4typeES4_m.exit.i.i
-  %.sink.i.i = phi ptr [ %18, %_ZN5folly2io13QueueAppender9writeSlowIjEENSt9enable_ifIXsr3std13is_arithmeticIT_EE5valueEvE4typeES4_m.exit.i.i ], [ %7, %if.then.i.i ]
+_ZN5folly2io6detail8WritableINS0_13QueueAppenderEE7writeBEIjEEvT_.exit: ; preds = %if.else, %_ZN5folly2io13QueueAppender9writeSlowIjEENSt9enable_ifIXsr3std13is_arithmeticIT_EE5valueEvE4typeES4_m.exit.i.i
+  %.sink.i.i = phi ptr [ %18, %_ZN5folly2io13QueueAppender9writeSlowIjEENSt9enable_ifIXsr3std13is_arithmeticIT_EE5valueEvE4typeES4_m.exit.i.i ], [ %7, %if.else ]
   %19 = tail call noundef i32 @llvm.bswap.i32(i32 %or21)
-  store i32 %19, ptr %.sink.i.i, align 1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sink.i.i) ]
+  store i32 %19, ptr %.sink4.i.i, align 1
   %.pn.i.i = load ptr, ptr %buf, align 8
   %storemerge.i.i = getelementptr inbounds nuw i8, ptr %.pn.i.i, i64 4
   store ptr %storemerge.i.i, ptr %buf, align 8
@@ -720,7 +716,7 @@ for.inc:                                          ; preds = %if.then, %_ZN5folly
   %wbits.1 = phi i8 [ %conv11, %if.then ], [ %conv15, %_ZN5folly2io6detail8WritableINS0_13QueueAppenderEE7writeBEIjEEvT_.exit ]
   %inc = add nuw i64 %i.038, 1
   %exitcond.not = icmp eq i64 %inc, %sub.ptr.sub.i
-  br i1 %exitcond.not, label %for.end, label %for.body, !llvm.loop !9
+  br i1 %exitcond.not, label %for.end, label %for.body, !llvm.loop !8
 
 for.end:                                          ; preds = %for.inc
   %20 = and i8 %wbits.1, 7
@@ -770,7 +766,7 @@ if.then.i.i32:                                    ; preds = %if.then46
   br label %if.end.i.i
 
 if.end.i.i:                                       ; preds = %if.then.i.i32, %if.then46
-  %buf.addr.0.i.i = phi ptr [ %add.ptr.i.i, %if.then.i.i32 ], [ %w, %if.then46 ]
+  %buf.addr.0.i.i = phi ptr [ %add.ptr.i.i, %if.then.i.i ], [ %w, %if.then46 ]
   %sub.i.i = sub nsw i64 %conv54, %.sroa.speculated24.i.i
   %cmp4.not29.i.i = icmp eq i64 %sub.i.i, 0
   br i1 %cmp4.not29.i.i, label %_ZN5folly2io6detail8WritableINS0_13QueueAppenderEE4pushEPKhm.exit, label %while.body.lr.ph.i.i
@@ -825,7 +821,7 @@ _ZN5folly10IOBufQueue11preallocateEmmm.exit.i.i:  ; preds = %if.end.i.i.i, %if.t
   %add.ptr14.i.i = getelementptr inbounds i8, ptr %buf.addr.131.i.i, i64 %31
   %sub16.i.i = sub i64 %storemerge30.i.i, %31
   %cmp4.not.i.i = icmp eq i64 %sub16.i.i, 0
-  br i1 %cmp4.not.i.i, label %_ZN5folly2io6detail8WritableINS0_13QueueAppenderEE4pushEPKhm.exit, label %while.body.i.i, !llvm.loop !10
+  br i1 %cmp4.not.i.i, label %_ZN5folly2io6detail8WritableINS0_13QueueAppenderEE4pushEPKhm.exit, label %while.body.i.i, !llvm.loop !9
 
 _ZN5folly2io6detail8WritableINS0_13QueueAppenderEE4pushEPKhm.exit: ; preds = %_ZN5folly10IOBufQueue11preallocateEmmm.exit.i.i, %if.end.i.i
   %conv55 = zext nneg i8 %shr48 to i32
@@ -866,7 +862,7 @@ for.body:                                         ; preds = %for.body.lr.ph, %fo
   %add = add i32 %totalBits.09, %conv
   %inc = add nuw i64 %i.08, 1
   %exitcond.not = icmp eq i64 %inc, %sub.ptr.sub.i
-  br i1 %exitcond.not, label %for.end, label %for.body, !llvm.loop !11
+  br i1 %exitcond.not, label %for.end, label %for.body, !llvm.loop !10
 
 for.end:                                          ; preds = %for.body, %entry
   %totalBits.0.lcssa = phi i32 [ 0, %entry ], [ %add, %for.body ]
@@ -903,7 +899,7 @@ entry:
   %ref.tmp = alloca %"class.proxygen::huffman::HuffTree", align 8
   %0 = load atomic i8, ptr @_ZGVZN8proxygen7huffman8huffTreeEvE8huffTree acquire, align 8
   %guard.uninitialized = icmp eq i8 %0, 0
-  br i1 %guard.uninitialized, label %init.check, label %init.end, !prof !12
+  br i1 %guard.uninitialized, label %init.check, label %init.end, !prof !11
 
 init.check:                                       ; preds = %entry
   %1 = tail call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZN8proxygen7huffman8huffTreeEvE8huffTree) #27
@@ -1113,7 +1109,7 @@ if.then3:                                         ; preds = %if.else
   call void @llvm.lifetime.start.p0(ptr nonnull %ref.tmp.i.i.i.i)
   %0 = load atomic i8, ptr @_ZGVZN5folly6detail14FastStaticBoolIZNS0_23usingJEMallocOrTCMallocEvE11InitializerE3getESt12memory_orderE2rv acquire, align 8
   %guard.uninitialized.i.i.i.i = icmp eq i8 %0, 0
-  br i1 %guard.uninitialized.i.i.i.i, label %init.check.i.i.i.i, label %_ZN5folly10canNallocxEv.exit.i, !prof !12
+  br i1 %guard.uninitialized.i.i.i.i, label %init.check.i.i.i.i, label %_ZN5folly10canNallocxEv.exit.i, !prof !11
 
 init.check.i.i.i.i:                               ; preds = %if.then3
   %1 = tail call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZN5folly6detail14FastStaticBoolIZNS0_23usingJEMallocOrTCMallocEvE11InitializerE3getESt12memory_orderE2rv) #27
@@ -1241,7 +1237,7 @@ if.end.i:                                         ; preds = %if.end7
   call void @llvm.lifetime.start.p0(ptr nonnull %ref.tmp.i.i.i.i)
   %9 = load atomic i8, ptr @_ZGVZN5folly6detail14FastStaticBoolIZNS0_23usingJEMallocOrTCMallocEvE11InitializerE3getESt12memory_orderE2rv acquire, align 8
   %guard.uninitialized.i.i.i.i = icmp eq i8 %9, 0
-  br i1 %guard.uninitialized.i.i.i.i, label %init.check.i.i.i.i, label %_ZN5folly10canNallocxEv.exit.i, !prof !12
+  br i1 %guard.uninitialized.i.i.i.i, label %init.check.i.i.i.i, label %_ZN5folly10canNallocxEv.exit.i, !prof !11
 
 init.check.i.i.i.i:                               ; preds = %if.end.i
   %10 = tail call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZN5folly6detail14FastStaticBoolIZNS0_23usingJEMallocOrTCMallocEvE11InitializerE3getESt12memory_orderE2rv) #27
@@ -1301,7 +1297,7 @@ entry:
   call void @llvm.lifetime.start.p0(ptr nonnull %ref.tmp.i.i)
   %0 = load atomic i8, ptr @_ZGVZN5folly6detail14FastStaticBoolIZNS_13usingJEMallocEvE11InitializerE3getESt12memory_orderE2rv acquire, align 8
   %guard.uninitialized.i.i = icmp eq i8 %0, 0
-  br i1 %guard.uninitialized.i.i, label %init.check.i.i, label %_ZN5folly13usingJEMallocEv.exit, !prof !12
+  br i1 %guard.uninitialized.i.i, label %init.check.i.i, label %_ZN5folly13usingJEMallocEv.exit, !prof !11
 
 init.check.i.i:                                   ; preds = %entry
   %1 = tail call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZN5folly6detail14FastStaticBoolIZNS_13usingJEMallocEvE11InitializerE3getESt12memory_orderE2rv) #27
@@ -1325,7 +1321,7 @@ lor.rhs:                                          ; preds = %_ZN5folly13usingJEM
   call void @llvm.lifetime.start.p0(ptr nonnull %ref.tmp.i.i1)
   %3 = load atomic i8, ptr @_ZGVZN5folly6detail14FastStaticBoolIZNS_13usingTCMallocEvE11InitializerE3getESt12memory_orderE2rv acquire, align 8
   %guard.uninitialized.i.i2 = icmp eq i8 %3, 0
-  br i1 %guard.uninitialized.i.i2, label %init.check.i.i4, label %_ZN5folly13usingTCMallocEv.exit, !prof !12
+  br i1 %guard.uninitialized.i.i2, label %init.check.i.i4, label %_ZN5folly13usingTCMallocEv.exit, !prof !11
 
 init.check.i.i4:                                  ; preds = %lor.rhs
   %4 = call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZN5folly6detail14FastStaticBoolIZNS_13usingTCMallocEvE11InitializerE3getESt12memory_orderE2rv) #27
@@ -1402,7 +1398,7 @@ if.end14:                                         ; preds = %if.end
   %12 = load volatile i64, ptr %11, align 8
   %13 = load atomic i8, ptr @_ZGVZZN5folly13usingJEMallocEvENK11InitializerclEvE3ptr acquire, align 8
   %guard.uninitialized = icmp eq i8 %13, 0
-  br i1 %guard.uninitialized, label %init.check, label %init.end, !prof !12
+  br i1 %guard.uninitialized, label %init.check, label %init.end, !prof !11
 
 init.check:                                       ; preds = %if.end14
   %14 = call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZZN5folly13usingJEMallocEvENK11InitializerclEvE3ptr) #27
@@ -1493,7 +1489,7 @@ terminate.lpad.i:                                 ; preds = %if.end
 _ZN5folly26getTCMallocNumericPropertyEPKcPm.exit: ; preds = %if.end
   %5 = load atomic i8, ptr @_ZGVZZN5folly13usingTCMallocEvENK11InitializerclEvE3ptr acquire, align 8
   %guard.uninitialized = icmp eq i8 %5, 0
-  br i1 %guard.uninitialized, label %init.check, label %init.end, !prof !12
+  br i1 %guard.uninitialized, label %init.check, label %init.end, !prof !11
 
 init.check:                                       ; preds = %_ZN5folly26getTCMallocNumericPropertyEPKcPm.exit
   %6 = call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZZN5folly13usingTCMallocEvENK11InitializerclEvE3ptr) #27
@@ -1622,7 +1618,7 @@ if.then3:                                         ; preds = %if.end
   call void @llvm.lifetime.start.p0(ptr nonnull %ref.tmp.i.i.i.i)
   %1 = load atomic i8, ptr @_ZGVZN5folly6detail14FastStaticBoolIZNS0_23usingJEMallocOrTCMallocEvE11InitializerE3getESt12memory_orderE2rv acquire, align 8
   %guard.uninitialized.i.i.i.i = icmp eq i8 %1, 0
-  br i1 %guard.uninitialized.i.i.i.i, label %init.check.i.i.i.i, label %_ZN5folly10canNallocxEv.exit.i, !prof !12
+  br i1 %guard.uninitialized.i.i.i.i, label %init.check.i.i.i.i, label %_ZN5folly10canNallocxEv.exit.i, !prof !11
 
 init.check.i.i.i.i:                               ; preds = %if.then3
   %2 = tail call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZN5folly6detail14FastStaticBoolIZNS0_23usingJEMallocOrTCMallocEvE11InitializerE3getESt12memory_orderE2rv) #27
@@ -1886,7 +1882,7 @@ if.end.i:                                         ; preds = %if.end7
   call void @llvm.lifetime.start.p0(ptr nonnull %ref.tmp.i.i.i.i)
   %9 = load atomic i8, ptr @_ZGVZN5folly6detail14FastStaticBoolIZNS0_23usingJEMallocOrTCMallocEvE11InitializerE3getESt12memory_orderE2rv acquire, align 8
   %guard.uninitialized.i.i.i.i = icmp eq i8 %9, 0
-  br i1 %guard.uninitialized.i.i.i.i, label %init.check.i.i.i.i, label %_ZN5folly10canNallocxEv.exit.i, !prof !12
+  br i1 %guard.uninitialized.i.i.i.i, label %init.check.i.i.i.i, label %_ZN5folly10canNallocxEv.exit.i, !prof !11
 
 init.check.i.i.i.i:                               ; preds = %if.end.i
   %10 = tail call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZN5folly6detail14FastStaticBoolIZNS0_23usingJEMallocOrTCMallocEvE11InitializerE3getESt12memory_orderE2rv) #27
@@ -2024,8 +2020,7 @@ attributes #32 = { nounwind allocsize(1) }
 !5 = !{!"llvm.loop.mustprogress"}
 !6 = distinct !{!6, !5}
 !7 = distinct !{!7, !5}
-!8 = !{}
+!8 = distinct !{!8, !5}
 !9 = distinct !{!9, !5}
 !10 = distinct !{!10, !5}
-!11 = distinct !{!11, !5}
-!12 = !{!"branch_weights", i32 1, i32 1048575}
+!11 = !{!"branch_weights", i32 1, i32 1048575}
diff --git a/bench/proxygen/optimized/QPACKHeaderTable.ll b/bench/proxygen/optimized/QPACKHeaderTable.ll
index 9396746a86e..b9ef5357ecc 100644
--- a/bench/proxygen/optimized/QPACKHeaderTable.ll
+++ b/bench/proxygen/optimized/QPACKHeaderTable.ll
@@ -933,12 +933,15 @@ if.end20.i:                                       ; preds = %while.end.i
 
 if.end:                                           ; preds = %land.rhs.i.i.i.i, %while.body.i, %if.end.i.i.i.i.i
   %arrayidx.i.i.i.i.le = getelementptr inbounds nuw %"union.std::aligned_storage<4, 4>::type", ptr %rawItems_.i.i, i64 %conv9.i
-  %20 = load ptr, ptr %names_, align 8, !nonnull !12, !noundef !12
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %arrayidx.i.i.i.i.le) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %arrayidx.i.i.i.i.le) ]
+  %20 = load ptr, ptr %names_, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %20) ]
   %21 = load i32, ptr %arrayidx.i.i.i.i.le, align 4
   %idx.ext8.i.i = zext i32 %21 to i64
   %add.ptr9.i.i = getelementptr inbounds nuw %"struct.std::pair", ptr %20, i64 %idx.ext8.i.i
   %second = getelementptr inbounds nuw i8, ptr %add.ptr9.i.i, i64 8
-  %22 = load ptr, ptr %second, align 8, !noalias !13
+  %22 = load ptr, ptr %second, align 8, !noalias !12
   %cmp.i.i.i34.not57 = icmp eq ptr %second, %22
   br i1 %cmp.i.i.i34.not57, label %for.end, label %for.body.lr.ph
 
@@ -978,9 +981,9 @@ for.body.us:                                      ; preds = %for.body.lr.ph.spli
 
 for.inc.us:                                       ; preds = %for.body.us
   %29 = load ptr, ptr %_M_prev.i.i.us, align 8
-  %30 = load ptr, ptr %second, align 8, !noalias !13
+  %30 = load ptr, ptr %second, align 8, !noalias !12
   %cmp.i.i.i34.not.us = icmp eq ptr %29, %30
-  br i1 %cmp.i.i.i34.not.us, label %for.end, label %for.body.us, !llvm.loop !16
+  br i1 %cmp.i.i.i34.not.us, label %for.end, label %for.body.us, !llvm.loop !15
 
 for.body.lr.ph.split:                             ; preds = %for.body.lr.ph
   br i1 %allowVulnerable, label %for.body.lr.ph.split.split.us, label %for.body
@@ -1010,7 +1013,7 @@ for.body.us61.us:                                 ; preds = %for.body.lr.ph.spli
 
 for.inc.us67.us:                                  ; preds = %for.body.us61.us
   %cmp.i.i.i34.not.us69.us = icmp eq ptr %32, %22
-  br i1 %cmp.i.i.i34.not.us69.us, label %for.end, label %for.body.us61.us, !llvm.loop !16
+  br i1 %cmp.i.i.i34.not.us69.us, label %for.end, label %for.body.us61.us, !llvm.loop !15
 
 for.body.us61:                                    ; preds = %for.body.lr.ph.split.split.us, %for.inc.us67
   %indexIt.sroa.0.058.us63 = phi ptr [ %36, %for.inc.us67 ], [ %second, %for.body.lr.ph.split.split.us ]
@@ -1042,7 +1045,7 @@ land.rhs.i.i.us:                                  ; preds = %for.body.us61
 
 for.inc.us67:                                     ; preds = %land.rhs.i.i.us, %for.body.us61
   %cmp.i.i.i34.not.us69 = icmp eq ptr %36, %22
-  br i1 %cmp.i.i.i34.not.us69, label %for.end, label %for.body.us61, !llvm.loop !16
+  br i1 %cmp.i.i.i34.not.us69, label %for.end, label %for.body.us61, !llvm.loop !15
 
 for.body:                                         ; preds = %for.body.lr.ph.split, %for.inc
   %41 = phi ptr [ %50, %for.inc ], [ %22, %for.body.lr.ph.split ]
@@ -1089,7 +1092,7 @@ if.then15:                                        ; preds = %_ZNSt11char_traitsI
 
 if.then15.for.inc_crit_edge:                      ; preds = %if.then15
   %.pre = load ptr, ptr %_M_prev.i.i, align 8
-  %.pre96 = load ptr, ptr %second, align 8, !noalias !13
+  %.pre96 = load ptr, ptr %second, align 8, !noalias !12
   br label %for.inc
 
 if.then19:                                        ; preds = %if.then15, %land.rhs.i.i.us, %for.body.us61.us, %for.body.us, %for.body.us.us
@@ -1102,14 +1105,14 @@ for.inc:                                          ; preds = %if.then15.for.inc_c
   %51 = phi ptr [ %.pre, %if.then15.for.inc_crit_edge ], [ %42, %for.body ], [ %42, %_ZNSt11char_traitsIcE7compareEPKcS2_m.exit.i.i.i ]
   %encoderHasUnackedEntry.1 = phi i8 [ 1, %if.then15.for.inc_crit_edge ], [ %encoderHasUnackedEntry.059, %for.body ], [ %encoderHasUnackedEntry.059, %_ZNSt11char_traitsIcE7compareEPKcS2_m.exit.i.i.i ]
   %cmp.i.i.i34.not = icmp eq ptr %51, %50
-  br i1 %cmp.i.i.i34.not, label %for.end.loopexit87, label %for.body, !llvm.loop !16
+  br i1 %cmp.i.i.i34.not, label %for.end.loopexit87, label %for.body, !llvm.loop !15
 
 for.end.loopexit87:                               ; preds = %for.inc
   %52 = zext nneg i8 %encoderHasUnackedEntry.1 to i32
   br label %for.end
 
 for.end:                                          ; preds = %for.inc.us67, %for.inc.us67.us, %for.inc.us, %for.end.loopexit87, %if.end
-  %encoderHasUnackedEntry.0.lcssa = phi i32 [ 0, %if.end ], [ 0, %for.inc.us67.us ], [ 1, %for.inc.us ], [ %52, %for.end.loopexit87 ], [ 0, %for.inc.us67 ]
+  %encoderHasUnackedEntry.0.lcssa = phi i32 [ 0, %_ZNK5folly3f146detail21VectorContainerPolicyIN8proxygen15HPACKHeaderNameENSt7__cxx114listIjSaIjEEEvvvSt17integral_constantIbLb1EEE13makeConstIterERKNS1_11F14ItemIterIPNS1_8F14ChunkIjEEEE.exit ], [ 0, %for.inc.us67.us ], [ 1, %for.inc.us ], [ %52, %for.end.loopexit87 ], [ 0, %for.inc.us67 ]
   %. = sub nsw i32 0, %encoderHasUnackedEntry.0.lcssa
   br label %return
 
@@ -1715,7 +1718,7 @@ while.body:                                       ; preds = %land.rhs
   %cmp5 = icmp ult i32 %inc14, %14
   %cmp6 = icmp ult i32 %add, %needed
   %or.cond = select i1 %cmp5, i1 %cmp6, i1 false
-  br i1 %or.cond, label %land.lhs.true7, label %while.end, !llvm.loop !17
+  br i1 %or.cond, label %land.lhs.true7, label %while.end, !llvm.loop !16
 
 while.end:                                        ; preds = %land.rhs, %while.body, %land.lhs.true7, %if.end
   %cmp6.lcssa = phi i1 [ %cmp610, %if.end ], [ true, %land.lhs.true7 ], [ %cmp6, %while.body ], [ true, %land.rhs ]
@@ -1791,11 +1794,11 @@ _ZN8proxygen16QPACKHeaderTable8canIndexERKNS_15HPACKHeaderNameEN5folly5RangeIPKc
   br i1 %call8.i, label %if.then40, label %return
 
 if.then40:                                        ; preds = %land.rhs.i, %_ZN8proxygen16QPACKHeaderTable8canIndexERKNS_15HPACKHeaderNameEN5folly5RangeIPKcEE.exit
-  %9 = load ptr, ptr %value, align 8, !noalias !18
-  %10 = load i8, ptr %arrayidx.i.i.i.i.i, align 1, !noalias !18
+  %9 = load ptr, ptr %value, align 8, !noalias !17
+  %10 = load i8, ptr %arrayidx.i.i.i.i.i, align 1, !noalias !17
   %cmp.i.i.i.i.i = icmp ult i8 %10, 64
   %cond.i.i.i.i.i = select i1 %cmp.i.i.i.i.i, ptr %value, ptr %9
-  %11 = load i64, ptr %size_.i.i.i, align 8, !noalias !18
+  %11 = load i64, ptr %size_.i.i.i, align 8, !noalias !17
   %conv.i.i.i.i = zext i8 %10 to i64
   %sub.i.i.i.i = sub nsw i64 23, %conv.i.i.i.i
   %cmp.i.i.i.i6 = icmp ult i8 %10, 24
@@ -2294,7 +2297,7 @@ while.body.i.i.i.i.i.i:                           ; preds = %for.body, %while.bo
   %2 = load ptr, ptr %__cur.05.i.i.i.i.i.i, align 8
   tail call void @_ZdlPv(ptr noundef nonnull %__cur.05.i.i.i.i.i.i) #31
   %cmp.not.i.i.i.i.i.i = icmp eq ptr %2, %second.i.i.i
-  br i1 %cmp.not.i.i.i.i.i.i, label %_ZNSt7__cxx114listIjSaIjEED2Ev.exit.i.i.i, label %while.body.i.i.i.i.i.i, !llvm.loop !21
+  br i1 %cmp.not.i.i.i.i.i.i, label %_ZNSt7__cxx114listIjSaIjEED2Ev.exit.i.i.i, label %while.body.i.i.i.i.i.i, !llvm.loop !20
 
 _ZNSt7__cxx114listIjSaIjEED2Ev.exit.i.i.i:        ; preds = %while.body.i.i.i.i.i.i, %for.body
   %3 = load ptr, ptr %arrayidx, align 8
@@ -2335,7 +2338,7 @@ _ZNSt16allocator_traitsISaISt4pairIKN8proxygen15HPACKHeaderNameENSt7__cxx114list
   store ptr null, ptr %arrayidx, align 8
   %inc = add nuw i64 %i.04, 1
   %exitcond.not = icmp eq i64 %inc, %size
-  br i1 %exitcond.not, label %for.end, label %for.body, !llvm.loop !22
+  br i1 %exitcond.not, label %for.end, label %for.body, !llvm.loop !21
 
 for.end:                                          ; preds = %_ZNSt16allocator_traitsISaISt4pairIKN8proxygen15HPACKHeaderNameENSt7__cxx114listIjSaIjEEEEEE7destroyIS8_EEvRS9_PT_.exit, %entry
   ret void
@@ -2574,7 +2577,7 @@ if.end.i:                                         ; preds = %entry
   call void @llvm.lifetime.start.p0(ptr nonnull %ref.tmp.i.i.i.i)
   %0 = load atomic i8, ptr @_ZGVZN5folly6detail14FastStaticBoolIZNS0_23usingJEMallocOrTCMallocEvE11InitializerE3getESt12memory_orderE2rv acquire, align 8
   %guard.uninitialized.i.i.i.i = icmp eq i8 %0, 0
-  br i1 %guard.uninitialized.i.i.i.i, label %init.check.i.i.i.i, label %_ZN5folly10canNallocxEv.exit.i, !prof !23
+  br i1 %guard.uninitialized.i.i.i.i, label %init.check.i.i.i.i, label %_ZN5folly10canNallocxEv.exit.i, !prof !22
 
 init.check.i.i.i.i:                               ; preds = %if.end.i
   %1 = tail call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZN5folly6detail14FastStaticBoolIZNS0_23usingJEMallocOrTCMallocEvE11InitializerE3getESt12memory_orderE2rv) #28
@@ -2645,7 +2648,7 @@ entry:
   call void @llvm.lifetime.start.p0(ptr nonnull %ref.tmp.i.i)
   %0 = load atomic i8, ptr @_ZGVZN5folly6detail14FastStaticBoolIZNS_13usingJEMallocEvE11InitializerE3getESt12memory_orderE2rv acquire, align 8
   %guard.uninitialized.i.i = icmp eq i8 %0, 0
-  br i1 %guard.uninitialized.i.i, label %init.check.i.i, label %_ZN5folly13usingJEMallocEv.exit, !prof !23
+  br i1 %guard.uninitialized.i.i, label %init.check.i.i, label %_ZN5folly13usingJEMallocEv.exit, !prof !22
 
 init.check.i.i:                                   ; preds = %entry
   %1 = tail call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZN5folly6detail14FastStaticBoolIZNS_13usingJEMallocEvE11InitializerE3getESt12memory_orderE2rv) #28
@@ -2669,7 +2672,7 @@ lor.rhs:                                          ; preds = %_ZN5folly13usingJEM
   call void @llvm.lifetime.start.p0(ptr nonnull %ref.tmp.i.i1)
   %3 = load atomic i8, ptr @_ZGVZN5folly6detail14FastStaticBoolIZNS_13usingTCMallocEvE11InitializerE3getESt12memory_orderE2rv acquire, align 8
   %guard.uninitialized.i.i2 = icmp eq i8 %3, 0
-  br i1 %guard.uninitialized.i.i2, label %init.check.i.i4, label %_ZN5folly13usingTCMallocEv.exit, !prof !23
+  br i1 %guard.uninitialized.i.i2, label %init.check.i.i4, label %_ZN5folly13usingTCMallocEv.exit, !prof !22
 
 init.check.i.i4:                                  ; preds = %lor.rhs
   %4 = call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZN5folly6detail14FastStaticBoolIZNS_13usingTCMallocEvE11InitializerE3getESt12memory_orderE2rv) #28
@@ -2737,7 +2740,7 @@ if.end14:                                         ; preds = %if.end
   %12 = load volatile i64, ptr %11, align 8
   %13 = load atomic i8, ptr @_ZGVZZN5folly13usingJEMallocEvENK11InitializerclEvE3ptr acquire, align 8
   %guard.uninitialized = icmp eq i8 %13, 0
-  br i1 %guard.uninitialized, label %init.check, label %init.end, !prof !23
+  br i1 %guard.uninitialized, label %init.check, label %init.end, !prof !22
 
 init.check:                                       ; preds = %if.end14
   %14 = call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZZN5folly13usingJEMallocEvENK11InitializerclEvE3ptr) #28
@@ -2828,7 +2831,7 @@ terminate.lpad.i:                                 ; preds = %if.end
 _ZN5folly26getTCMallocNumericPropertyEPKcPm.exit: ; preds = %if.end
   %5 = load atomic i8, ptr @_ZGVZZN5folly13usingTCMallocEvENK11InitializerclEvE3ptr acquire, align 8
   %guard.uninitialized = icmp eq i8 %5, 0
-  br i1 %guard.uninitialized, label %init.check, label %init.end, !prof !23
+  br i1 %guard.uninitialized, label %init.check, label %init.end, !prof !22
 
 init.check:                                       ; preds = %_ZN5folly26getTCMallocNumericPropertyEPKcPm.exit
   %6 = call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZZN5folly13usingTCMallocEvENK11InitializerclEvE3ptr) #28
@@ -2960,7 +2963,7 @@ if.end.i:                                         ; preds = %if.end7
   call void @llvm.lifetime.start.p0(ptr nonnull %ref.tmp.i.i.i.i)
   %9 = load atomic i8, ptr @_ZGVZN5folly6detail14FastStaticBoolIZNS0_23usingJEMallocOrTCMallocEvE11InitializerE3getESt12memory_orderE2rv acquire, align 8
   %guard.uninitialized.i.i.i.i = icmp eq i8 %9, 0
-  br i1 %guard.uninitialized.i.i.i.i, label %init.check.i.i.i.i, label %_ZN5folly10canNallocxEv.exit.i, !prof !23
+  br i1 %guard.uninitialized.i.i.i.i, label %init.check.i.i.i.i, label %_ZN5folly10canNallocxEv.exit.i, !prof !22
 
 init.check.i.i.i.i:                               ; preds = %if.end.i
   %10 = tail call i32 @__cxa_guard_acquire(ptr nonnull @_ZGVZN5folly6detail14FastStaticBoolIZNS0_23usingJEMallocOrTCMallocEvE11InitializerE3getESt12memory_orderE2rv) #28
@@ -3236,15 +3239,14 @@ attributes #34 = { nounwind allocsize(0) }
 !9 = distinct !{!9, !8}
 !10 = distinct !{!10, !8}
 !11 = distinct !{!11, !8}
-!12 = !{}
-!13 = !{!14}
-!14 = distinct !{!14, !15, !"_ZNKSt7__cxx114listIjSaIjEE4rendEv: %agg.result"}
-!15 = distinct !{!15, !"_ZNKSt7__cxx114listIjSaIjEE4rendEv"}
+!12 = !{!13}
+!13 = distinct !{!13, !14, !"_ZNKSt7__cxx114listIjSaIjEE4rendEv: %agg.result"}
+!14 = distinct !{!14, !"_ZNKSt7__cxx114listIjSaIjEE4rendEv"}
+!15 = distinct !{!15, !8}
 !16 = distinct !{!16, !8}
-!17 = distinct !{!17, !8}
-!18 = !{!19}
-!19 = distinct !{!19, !20, !"_ZNK8proxygen11HPACKHeader4copyEv: %agg.result"}
-!20 = distinct !{!20, !"_ZNK8proxygen11HPACKHeader4copyEv"}
+!17 = !{!18}
+!18 = distinct !{!18, !19, !"_ZNK8proxygen11HPACKHeader4copyEv: %agg.result"}
+!19 = distinct !{!19, !"_ZNK8proxygen11HPACKHeader4copyEv"}
+!20 = distinct !{!20, !8}
 !21 = distinct !{!21, !8}
-!22 = distinct !{!22, !8}
-!23 = !{!"branch_weights", i32 1, i32 1048575}
+!22 = !{!"branch_weights", i32 1, i32 1048575}
diff --git a/bench/pyo3-rs/optimized/5a36ggkdtm8ke8bq.ll b/bench/pyo3-rs/optimized/5a36ggkdtm8ke8bq.ll
index 1e84dd27fae..69ba384bc50 100644
--- a/bench/pyo3-rs/optimized/5a36ggkdtm8ke8bq.ll
+++ b/bench/pyo3-rs/optimized/5a36ggkdtm8ke8bq.ll
@@ -93,7 +93,7 @@ define void @_ZN8pyo3_ffi8datetime17PyDateTime_IMPORT17hb5076f9810e237b1E() unna
 9:                                                ; preds = %6
   %10 = landingpad { ptr, i32 }
           filter [0 x ptr] zeroinitializer
-  call void @_ZN4core9panicking16panic_in_cleanup17hd62aa59d1fda1c9fE() #11, !noalias !5
+  call void @_ZN4core9panicking16panic_in_cleanup17hd62aa59d1fda1c9fE() #12, !noalias !5
   unreachable
 
 common.resume:                                    ; preds = %16, %19, %6
@@ -112,21 +112,25 @@ common.resume:                                    ; preds = %16, %19, %6
 16:                                               ; preds = %"_ZN4core6result19Result$LT$T$C$E$GT$6unwrap17h1901a67b92b931bbE.exit"
   %17 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %12) ]
   store i8 0, ptr %12, align 1
   %18 = icmp eq i64 %14, 0
   br i1 %18, label %common.resume, label %19
 
 19:                                               ; preds = %16
-  tail call void @__rust_dealloc(ptr noundef nonnull %12, i64 noundef range(i64 1, 0) %14, i64 noundef 1) #12
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %12) ]
+  tail call void @__rust_dealloc(ptr noundef nonnull %12, i64 noundef range(i64 1, 0) %14, i64 noundef 1) #13
   br label %common.resume
 
 20:                                               ; preds = %"_ZN4core6result19Result$LT$T$C$E$GT$6unwrap17h1901a67b92b931bbE.exit"
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %12) ]
   store i8 0, ptr %12, align 1
   %21 = icmp eq i64 %14, 0
   br i1 %21, label %"_ZN4core3ptr47drop_in_place$LT$alloc..ffi..c_str..CString$GT$17h66c7b83b18eb3a5cE.exit4", label %22
 
 22:                                               ; preds = %20
-  tail call void @__rust_dealloc(ptr noundef nonnull %12, i64 noundef range(i64 1, 0) %14, i64 noundef 1) #12
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %12) ]
+  tail call void @__rust_dealloc(ptr noundef nonnull %12, i64 noundef range(i64 1, 0) %14, i64 noundef 1) #13
   br label %"_ZN4core3ptr47drop_in_place$LT$alloc..ffi..c_str..CString$GT$17h66c7b83b18eb3a5cE.exit4"
 
 "_ZN4core3ptr47drop_in_place$LT$alloc..ffi..c_str..CString$GT$17h66c7b83b18eb3a5cE.exit4": ; preds = %20, %22
@@ -194,6 +198,9 @@ declare void @llvm.memcpy.p0.p0.i64(ptr noalias writeonly captures(none), ptr no
 ; Function Attrs: cold noreturn nonlazybind uwtable
 declare void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1, i64 noundef, ptr noundef nonnull align 1, ptr noalias noundef readonly align 8 dereferenceable(24), ptr noalias noundef readonly align 8 dereferenceable(24)) unnamed_addr #5
 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #6
+
 ; Function Attrs: nounwind nonlazybind allockind("free") uwtable
 declare void @__rust_dealloc(ptr allocptr noundef, i64 noundef, i64 noundef) unnamed_addr #6
 
@@ -227,13 +234,14 @@ attributes #2 = { nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x
 attributes #3 = { cold noreturn nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #4 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
 attributes #5 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #6 = { nounwind nonlazybind allockind("free") uwtable "alloc-family"="__rust_alloc" "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #7 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
+attributes #6 = { mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #7 = { nounwind nonlazybind allockind("free") uwtable "alloc-family"="__rust_alloc" "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #8 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
-attributes #9 = { noreturn }
-attributes #10 = { cold }
-attributes #11 = { cold noreturn nounwind }
-attributes #12 = { nounwind }
+attributes #9 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #10 = { noreturn }
+attributes #11 = { cold }
+attributes #12 = { cold noreturn nounwind }
+attributes #13 = { nounwind }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/qdrant-rs/optimized/23nlkzsh9fgdn4zq.ll b/bench/qdrant-rs/optimized/23nlkzsh9fgdn4zq.ll
index a1d976b91a6..ecab116ed91 100644
--- a/bench/qdrant-rs/optimized/23nlkzsh9fgdn4zq.ll
+++ b/bench/qdrant-rs/optimized/23nlkzsh9fgdn4zq.ll
@@ -104,6 +104,7 @@ define hidden void @_ZN3std10sys_common4once5futex4Once4call17h77a8a08035c8bad9E
   %28 = getelementptr inbounds nuw i8, ptr %7, i64 8
   store i32 1, ptr %28, align 8
   %.val = load ptr, ptr %2, align 8, !nonnull !9, !align !10, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %29 = load ptr, ptr %.val, align 8, !align !10, !noundef !9
   store ptr null, ptr %.val, align 8
   %30 = icmp eq ptr %29, null
@@ -118,6 +119,7 @@ define hidden void @_ZN3std10sys_common4once5futex4Once4call17h77a8a08035c8bad9E
 
 32:                                               ; preds = %.split19.us
   %.val.i = load ptr, ptr %29, align 8, !nonnull !9, !align !10, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   %33 = invoke noundef i64 @_ZN6common3cpu12get_num_cpus17h977909401643c6caE()
           to label %36 unwind label %34
 
@@ -216,6 +218,9 @@ declare void @llvm.lifetime.start.p0(ptr captures(none)) #6
 ; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite)
 declare void @llvm.lifetime.end.p0(ptr captures(none)) #6
 
+; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #7
+
 ; Function Attrs: nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none)
 declare i64 @llvm.umin.i64(i64, i64) #7
 
@@ -229,9 +234,10 @@ attributes #3 = { inlinehint mustprogress nofree norecurse nosync nounwind nonla
 attributes #4 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #5 = { cold noreturn nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #6 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
-attributes #7 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
-attributes #8 = { noreturn }
-attributes #9 = { cold noreturn nounwind }
+attributes #7 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #8 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
+attributes #9 = { noreturn }
+attributes #10 = { cold noreturn nounwind }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/qdrant-rs/optimized/242gbngcvruxs88t.ll b/bench/qdrant-rs/optimized/242gbngcvruxs88t.ll
index 0b3a8bf5398..87625a11068 100644
--- a/bench/qdrant-rs/optimized/242gbngcvruxs88t.ll
+++ b/bench/qdrant-rs/optimized/242gbngcvruxs88t.ll
@@ -175,6 +175,7 @@ define { ptr, i64 } @_ZN6common3cpu9CpuBudget3new17h4641c308df318575E(i64 %0) un
   store i64 1, ptr %.sroa.2.0..sroa_idx, align 8
   %.sroa.3.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 16
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %.sroa.3.0..sroa_idx, ptr noundef nonnull align 8 dereferenceable(40) %.sroa.3, i64 40, i1 false)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3) ]
   %4 = insertvalue { ptr, i64 } poison, ptr %3, 0
   %5 = insertvalue { ptr, i64 } %4, i64 %0, 1
   ret { ptr, i64 } %5
@@ -321,6 +322,7 @@ _ZN6common3cpu14get_cpu_budget17h98b86ed8cdaa4d53E.exit: ; preds = %0, %4, %6, %
   store i64 1, ptr %.sroa.2.0..sroa_idx.i, align 8
   %.sroa.3.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %17, i64 16
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %.sroa.3.0..sroa_idx.i, ptr noundef nonnull align 8 dereferenceable(40) %.sroa.3.i, i64 40, i1 false)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %17) ]
   %18 = insertvalue { ptr, i64 } poison, ptr %17, 0
   %19 = insertvalue { ptr, i64 } %18, i64 %16, 1
   call void @llvm.lifetime.end.p0(ptr nonnull %.sroa.3.i)
@@ -571,6 +573,9 @@ declare void @_ZN15thread_priority4unix27set_current_thread_priority17h314f853b5
 ; Function Attrs: inlinehint nonlazybind uwtable
 declare void @"_ZN4core6result19Result$LT$T$C$E$GT$7map_err17hf3fb010157cee8d6E"(ptr sret({ i32, [5 x i32] }) align 8, ptr align 8) unnamed_addr #4
 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #9
+
 ; Function Attrs: nonlazybind uwtable
 declare zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$GT$3fmt17h3926bd7f0c49eda5E"(ptr align 8, ptr align 8) unnamed_addr #0
 
@@ -601,12 +606,13 @@ attributes #5 = { mustprogress nocallback nofree nounwind willreturn memory(argm
 attributes #6 = { cold noreturn nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #7 = { mustprogress nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
 attributes #8 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #9 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
-attributes #10 = { nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
+attributes #9 = { mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #10 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
 attributes #11 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
-attributes #12 = { cold }
-attributes #13 = { cold noreturn nounwind }
-attributes #14 = { noreturn }
+attributes #12 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #13 = { cold }
+attributes #14 = { cold noreturn nounwind }
+attributes #15 = { noreturn }
 
 !llvm.module.flags = !{!0, !1}
 !llvm.ident = !{!2}
diff --git a/bench/qdrant-rs/optimized/pgs97hhgng8x0qz.ll b/bench/qdrant-rs/optimized/pgs97hhgng8x0qz.ll
index 1665f6f4bfe..49e0be53df9 100644
--- a/bench/qdrant-rs/optimized/pgs97hhgng8x0qz.ll
+++ b/bench/qdrant-rs/optimized/pgs97hhgng8x0qz.ll
@@ -452,6 +452,7 @@ _ZN4core5slice4sort20provide_sorted_batch17h009278cd587dc262E.exit: ; preds = %.
   br label %.invoke198
 
 162:                                              ; preds = %159
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre137) ]
   %163 = getelementptr inbounds { i64, i64 }, ptr %.pre137, i64 %.sroa.4.0.i46.ph
   %164 = load i64, ptr %163, align 8, !noundef !14
   %165 = getelementptr inbounds nuw i8, ptr %163, i64 8
@@ -483,6 +484,7 @@ _ZN4core5slice4sort20provide_sorted_batch17h009278cd587dc262E.exit: ; preds = %.
   unreachable
 
 171:                                              ; preds = %162
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre137) ]
   %172 = getelementptr inbounds { i64, i64 }, ptr %.pre137, i64 %167
   %173 = load i64, ptr %172, align 8, !noundef !14
   %174 = getelementptr inbounds nuw i8, ptr %172, i64 8
@@ -569,6 +571,7 @@ _ZN4core5slice4sort20provide_sorted_batch17h009278cd587dc262E.exit: ; preds = %.
   %.02819.i = phi ptr [ %214, %.lr.ph.i56 ], [ %188, %196 ]
   %.sroa.0.118.i = phi ptr [ %217, %.lr.ph.i56 ], [ %14, %196 ]
   %.sroa.18.217.i = phi ptr [ %212, %.lr.ph.i56 ], [ %187, %196 ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.118.i) ]
   %.028.val.i = load i32, ptr %.02819.i, align 4, !alias.scope !53, !noundef !14
   %.val36.i = load i32, ptr %.sroa.0.118.i, align 4, !noalias !53, !noundef !14
   %210 = icmp ult i32 %.028.val.i, %.val36.i
@@ -593,7 +596,8 @@ _ZN4core5slice4sort20provide_sorted_batch17h009278cd587dc262E.exit: ; preds = %.
   %220 = ptrtoint ptr %.sroa.10.1.i to i64
   %221 = ptrtoint ptr %.sroa.0.0.i55 to i64
   %222 = sub nuw i64 %220, %221
-  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 4 %.sroa.18.1.i, ptr align 4 %.sroa.0.0.i55, i64 %222, i1 false), !noalias !56
+  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 4 %.sroa.18.1.i, ptr nonnull align 4 %.sroa.0.0.i55, i64 %222, i1 false), !noalias !56
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre137) ]
   %223 = add i64 %173, %164
   store i64 %223, ptr %172, align 8
   store i64 %166, ptr %174, align 8
diff --git a/bench/quantlib/optimized/gaussian1dcapfloorengine.ll b/bench/quantlib/optimized/gaussian1dcapfloorengine.ll
index 05c449c13fd..2640dd5ce12 100644
--- a/bench/quantlib/optimized/gaussian1dcapfloorengine.ll
+++ b/bench/quantlib/optimized/gaussian1dcapfloorengine.ll
@@ -2096,16 +2096,19 @@ lpad273:                                          ; preds = %invoke.cont280
 invoke.cont280:                                   ; preds = %invoke.cont267, %invoke.cont297
   %j271.01155 = phi i64 [ %add, %invoke.cont297 ], [ 0, %invoke.cont267 ]
   %price.01154 = phi double [ %add299, %invoke.cont297 ], [ 0.000000e+00, %invoke.cont267 ]
-  %193 = load ptr, ptr %impl_.i.i, align 8, !tbaa !116, !nonnull !27, !noundef !27
+  %193 = load ptr, ptr %impl_.i.i, align 8, !tbaa !116
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %193) ]
   %194 = call noundef nonnull align 8 dereferenceable(152) ptr @__dynamic_cast(ptr nonnull %193, ptr nonnull @_ZTIN8QuantLib13Interpolation4ImplE, ptr nonnull @_ZTIN8QuantLib6detail17CoefficientHolderE, i64 -2) #26
   %c_.i = getelementptr inbounds nuw i8, ptr %194, i64 88
   %195 = load ptr, ptr %c_.i, align 8, !tbaa !105
   %add.ptr.i359 = getelementptr inbounds nuw double, ptr %195, i64 %j271.01155
   %196 = load double, ptr %add.ptr.i359, align 8, !tbaa !42
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %193) ]
   %b_.i = getelementptr inbounds nuw i8, ptr %194, i64 64
   %197 = load ptr, ptr %b_.i, align 8, !tbaa !105
   %add.ptr.i361 = getelementptr inbounds nuw double, ptr %197, i64 %j271.01155
   %198 = load double, ptr %add.ptr.i361, align 8, !tbaa !42
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %193) ]
   %a_.i = getelementptr inbounds nuw i8, ptr %194, i64 40
   %199 = load ptr, ptr %a_.i, align 8, !tbaa !105
   %add.ptr.i363 = getelementptr inbounds nuw double, ptr %199, i64 %j271.01155
@@ -2162,16 +2165,19 @@ lpad307:                                          ; preds = %invoke.cont377, %co
   br label %ehcleanup385
 
 invoke.cont336:                                   ; preds = %if.then304
-  %215 = load ptr, ptr %impl_.i.i, align 8, !tbaa !116, !nonnull !27, !noundef !27
+  %215 = load ptr, ptr %impl_.i.i, align 8, !tbaa !116
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %215) ]
   %216 = call noundef nonnull align 8 dereferenceable(152) ptr @__dynamic_cast(ptr nonnull %215, ptr nonnull @_ZTIN8QuantLib13Interpolation4ImplE, ptr nonnull @_ZTIN8QuantLib6detail17CoefficientHolderE, i64 -2) #26
   %c_.i378 = getelementptr inbounds nuw i8, ptr %216, i64 88
   %217 = load ptr, ptr %c_.i378, align 8, !tbaa !105
   %add.ptr.i380 = getelementptr inbounds nuw double, ptr %217, i64 %.lcssa1049
   %218 = load double, ptr %add.ptr.i380, align 8, !tbaa !42
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %215) ]
   %b_.i382 = getelementptr inbounds nuw i8, ptr %216, i64 64
   %219 = load ptr, ptr %b_.i382, align 8, !tbaa !105
   %add.ptr.i384 = getelementptr inbounds nuw double, ptr %219, i64 %.lcssa1049
   %220 = load double, ptr %add.ptr.i384, align 8, !tbaa !42
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %215) ]
   %a_.i386 = getelementptr inbounds nuw i8, ptr %216, i64 40
   %221 = load ptr, ptr %a_.i386, align 8, !tbaa !105
   %add.ptr.i388 = getelementptr inbounds nuw double, ptr %221, i64 %.lcssa1049
@@ -3098,16 +3104,19 @@ lpad559:                                          ; preds = %invoke.cont566
 invoke.cont566:                                   ; preds = %invoke.cont552, %invoke.cont584
   %j557.01165 = phi i64 [ %add581, %invoke.cont584 ], [ 0, %invoke.cont552 ]
   %price556.01164 = phi double [ %add586, %invoke.cont584 ], [ 0.000000e+00, %invoke.cont552 ]
-  %361 = load ptr, ptr %impl_.i.i624, align 8, !tbaa !116, !nonnull !27, !noundef !27
+  %361 = load ptr, ptr %impl_.i.i624, align 8, !tbaa !116
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %361) ]
   %362 = call noundef nonnull align 8 dereferenceable(152) ptr @__dynamic_cast(ptr nonnull %361, ptr nonnull @_ZTIN8QuantLib13Interpolation4ImplE, ptr nonnull @_ZTIN8QuantLib6detail17CoefficientHolderE, i64 -2) #26
   %c_.i625 = getelementptr inbounds nuw i8, ptr %362, i64 88
   %363 = load ptr, ptr %c_.i625, align 8, !tbaa !105
   %add.ptr.i626 = getelementptr inbounds nuw double, ptr %363, i64 %j557.01165
   %364 = load double, ptr %add.ptr.i626, align 8, !tbaa !42
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %361) ]
   %b_.i628 = getelementptr inbounds nuw i8, ptr %362, i64 64
   %365 = load ptr, ptr %b_.i628, align 8, !tbaa !105
   %add.ptr.i629 = getelementptr inbounds nuw double, ptr %365, i64 %j557.01165
   %366 = load double, ptr %add.ptr.i629, align 8, !tbaa !42
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %361) ]
   %a_.i631 = getelementptr inbounds nuw i8, ptr %362, i64 40
   %367 = load ptr, ptr %a_.i631, align 8, !tbaa !105
   %add.ptr.i632 = getelementptr inbounds nuw double, ptr %367, i64 %j557.01165
@@ -3164,14 +3173,17 @@ lpad597:                                          ; preds = %invoke.cont649, %co
   br label %ehcleanup656
 
 invoke.cont626:                                   ; preds = %if.then593
-  %383 = load ptr, ptr %impl_.i.i624, align 8, !tbaa !116, !nonnull !27, !noundef !27
+  %383 = load ptr, ptr %impl_.i.i624, align 8, !tbaa !116
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %383) ]
   %384 = call noundef nonnull align 8 dereferenceable(152) ptr @__dynamic_cast(ptr nonnull %383, ptr nonnull @_ZTIN8QuantLib13Interpolation4ImplE, ptr nonnull @_ZTIN8QuantLib6detail17CoefficientHolderE, i64 -2) #26
   %c_.i647 = getelementptr inbounds nuw i8, ptr %384, i64 88
   %385 = load ptr, ptr %c_.i647, align 8, !tbaa !105
   %386 = load double, ptr %385, align 8, !tbaa !42
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %383) ]
   %b_.i650 = getelementptr inbounds nuw i8, ptr %384, i64 64
   %387 = load ptr, ptr %b_.i650, align 8, !tbaa !105
   %388 = load double, ptr %387, align 8, !tbaa !42
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %383) ]
   %a_.i653 = getelementptr inbounds nuw i8, ptr %384, i64 40
   %389 = load ptr, ptr %a_.i653, align 8, !tbaa !105
   %390 = load double, ptr %389, align 8, !tbaa !42
diff --git a/bench/quantlib/optimized/gaussian1dmodel.ll b/bench/quantlib/optimized/gaussian1dmodel.ll
index a781b79162c..1260f4df13a 100644
--- a/bench/quantlib/optimized/gaussian1dmodel.ll
+++ b/bench/quantlib/optimized/gaussian1dmodel.ll
@@ -4483,7 +4483,10 @@ invoke.cont60:                                    ; preds = %for.cond.cleanup
 
 invoke.cont73.lr.ph:                              ; preds = %invoke.cont60
   %impl_.i.i = getelementptr inbounds nuw i8, ptr %payoff, i64 16
-  %25 = load ptr, ptr %impl_.i.i, align 8, !tbaa !180, !nonnull !38, !noundef !38
+  %25 = load ptr, ptr %impl_.i.i, align 8, !tbaa !180
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %25) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %25) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %25) ]
   %.pre = load double, ptr %12, align 8, !tbaa !176
   br label %invoke.cont73
 
@@ -4661,17 +4664,20 @@ if.else:                                          ; preds = %if.then
 
 if.end.thread:                                    ; preds = %if.else
   %impl_.i.i107 = getelementptr inbounds nuw i8, ptr %payoff, i64 16
-  %88 = load ptr, ptr %impl_.i.i107, align 8, !tbaa !180, !nonnull !38, !noundef !38
+  %88 = load ptr, ptr %impl_.i.i107, align 8, !tbaa !180
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %88) ]
   %89 = call noundef nonnull align 8 dereferenceable(152) ptr @__dynamic_cast(ptr nonnull %88, ptr nonnull @_ZTIN8QuantLib13Interpolation4ImplE, ptr nonnull @_ZTIN8QuantLib6detail17CoefficientHolderE, i64 -2) #29
   %c_.i108 = getelementptr inbounds nuw i8, ptr %89, i64 88
   %sub133 = add i64 %13, -2
   %90 = load ptr, ptr %c_.i108, align 8, !tbaa !182
   %add.ptr.i110 = getelementptr inbounds nuw double, ptr %90, i64 %sub133
   %91 = load double, ptr %add.ptr.i110, align 8, !tbaa !176
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %88) ]
   %b_.i112 = getelementptr inbounds nuw i8, ptr %89, i64 64
   %92 = load ptr, ptr %b_.i112, align 8, !tbaa !182
   %add.ptr.i114 = getelementptr inbounds nuw double, ptr %92, i64 %sub133
   %93 = load double, ptr %add.ptr.i114, align 8, !tbaa !176
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %88) ]
   %a_.i116 = getelementptr inbounds nuw i8, ptr %89, i64 40
   %94 = load ptr, ptr %a_.i116, align 8, !tbaa !182
   %add.ptr.i118 = getelementptr inbounds nuw double, ptr %94, i64 %sub133
@@ -4746,14 +4752,17 @@ if.end.thread:                                    ; preds = %if.else
 
 invoke.cont167:                                   ; preds = %if.else
   %impl_.i.i162 = getelementptr inbounds nuw i8, ptr %payoff, i64 16
-  %121 = load ptr, ptr %impl_.i.i162, align 8, !tbaa !180, !nonnull !38, !noundef !38
+  %121 = load ptr, ptr %impl_.i.i162, align 8, !tbaa !180
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %121) ]
   %122 = call noundef nonnull align 8 dereferenceable(152) ptr @__dynamic_cast(ptr nonnull %121, ptr nonnull @_ZTIN8QuantLib13Interpolation4ImplE, ptr nonnull @_ZTIN8QuantLib6detail17CoefficientHolderE, i64 -2) #29
   %c_.i163 = getelementptr inbounds nuw i8, ptr %122, i64 88
   %123 = load ptr, ptr %c_.i163, align 8, !tbaa !182
   %124 = load double, ptr %123, align 8, !tbaa !176
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %121) ]
   %b_.i166 = getelementptr inbounds nuw i8, ptr %122, i64 64
   %125 = load ptr, ptr %b_.i166, align 8, !tbaa !182
   %126 = load double, ptr %125, align 8, !tbaa !176
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %121) ]
   %a_.i169 = getelementptr inbounds nuw i8, ptr %122, i64 40
   %127 = load ptr, ptr %a_.i169, align 8, !tbaa !182
   %128 = load double, ptr %127, align 8, !tbaa !176
diff --git a/bench/quantlib/optimized/gaussian1dnonstandardswaptionengine.ll b/bench/quantlib/optimized/gaussian1dnonstandardswaptionengine.ll
index 8416af32cb5..66e1430ec69 100644
--- a/bench/quantlib/optimized/gaussian1dnonstandardswaptionengine.ll
+++ b/bench/quantlib/optimized/gaussian1dnonstandardswaptionengine.ll
@@ -3847,16 +3847,19 @@ lpad377:                                          ; preds = %invoke.cont384
 invoke.cont384:                                   ; preds = %invoke.cont371, %invoke.cont402
   %i375.01763 = phi i64 [ %add399, %invoke.cont402 ], [ 0, %invoke.cont371 ]
   %price.11762 = phi double [ %166, %invoke.cont402 ], [ 0.000000e+00, %invoke.cont371 ]
-  %154 = load ptr, ptr %impl_.i.i, align 8, !tbaa !167, !nonnull !27, !noundef !27
+  %154 = load ptr, ptr %impl_.i.i, align 8, !tbaa !167
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %154) ]
   %155 = call noundef nonnull align 8 dereferenceable(152) ptr @__dynamic_cast(ptr nonnull %154, ptr nonnull @_ZTIN8QuantLib13Interpolation4ImplE, ptr nonnull @_ZTIN8QuantLib6detail17CoefficientHolderE, i64 -2) #28
   %c_.i = getelementptr inbounds nuw i8, ptr %155, i64 88
   %156 = load ptr, ptr %c_.i, align 8, !tbaa !69
   %add.ptr.i433 = getelementptr inbounds nuw double, ptr %156, i64 %i375.01763
   %157 = load double, ptr %add.ptr.i433, align 8, !tbaa !70
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %154) ]
   %b_.i = getelementptr inbounds nuw i8, ptr %155, i64 64
   %158 = load ptr, ptr %b_.i, align 8, !tbaa !69
   %add.ptr.i435 = getelementptr inbounds nuw double, ptr %158, i64 %i375.01763
   %159 = load double, ptr %add.ptr.i435, align 8, !tbaa !70
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %154) ]
   %a_.i = getelementptr inbounds nuw i8, ptr %155, i64 40
   %160 = load ptr, ptr %a_.i, align 8, !tbaa !69
   %add.ptr.i437 = getelementptr inbounds nuw double, ptr %160, i64 %i375.01763
@@ -3913,7 +3916,8 @@ lpad412:                                          ; preds = %invoke.cont482, %in
   br label %ehcleanup503
 
 if.else440:                                       ; preds = %if.then409
-  %179 = load ptr, ptr %impl_.i.i, align 8, !tbaa !167, !nonnull !27, !noundef !27
+  %179 = load ptr, ptr %impl_.i.i, align 8, !tbaa !167
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %179) ]
   %180 = call noundef nonnull align 8 dereferenceable(152) ptr @__dynamic_cast(ptr nonnull %179, ptr nonnull @_ZTIN8QuantLib13Interpolation4ImplE, ptr nonnull @_ZTIN8QuantLib6detail17CoefficientHolderE, i64 -2) #28
   %c_.i452 = getelementptr inbounds nuw i8, ptr %180, i64 88
   %181 = load ptr, ptr %c_.i452, align 8, !tbaa !69
@@ -3922,10 +3926,12 @@ if.else440:                                       ; preds = %if.then409
 invoke.cont443:                                   ; preds = %if.else440
   %add.ptr.i454 = getelementptr inbounds nuw double, ptr %181, i64 %.lcssa
   %182 = load double, ptr %add.ptr.i454, align 8, !tbaa !70
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %179) ]
   %b_.i456 = getelementptr inbounds nuw i8, ptr %180, i64 64
   %183 = load ptr, ptr %b_.i456, align 8, !tbaa !69
   %add.ptr.i458 = getelementptr inbounds nuw double, ptr %183, i64 %.lcssa
   %184 = load double, ptr %add.ptr.i458, align 8, !tbaa !70
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %179) ]
   %a_.i460 = getelementptr inbounds nuw i8, ptr %180, i64 40
   %185 = load ptr, ptr %a_.i460, align 8, !tbaa !69
   %add.ptr.i462 = getelementptr inbounds nuw double, ptr %185, i64 %.lcssa
@@ -3946,9 +3952,11 @@ if.end479.thread:                                 ; preds = %invoke.cont443
 
 invoke.cont482:                                   ; preds = %if.else440
   %192 = load double, ptr %181, align 8, !tbaa !70
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %179) ]
   %b_.i473 = getelementptr inbounds nuw i8, ptr %180, i64 64
   %193 = load ptr, ptr %b_.i473, align 8, !tbaa !69
   %194 = load double, ptr %193, align 8, !tbaa !70
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %179) ]
   %a_.i476 = getelementptr inbounds nuw i8, ptr %180, i64 40
   %195 = load ptr, ptr %a_.i476, align 8, !tbaa !69
   %196 = load double, ptr %195, align 8, !tbaa !70
@@ -4327,16 +4335,19 @@ lpad626:                                          ; preds = %invoke.cont633
 invoke.cont633:                                   ; preds = %invoke.cont620, %invoke.cont651
   %i624.01771 = phi i64 [ %add648, %invoke.cont651 ], [ 0, %invoke.cont620 ]
   %price522.11770 = phi double [ %269, %invoke.cont651 ], [ 0.000000e+00, %invoke.cont620 ]
-  %257 = load ptr, ptr %impl_.i.i554, align 8, !tbaa !167, !nonnull !27, !noundef !27
+  %257 = load ptr, ptr %impl_.i.i554, align 8, !tbaa !167
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %257) ]
   %258 = call noundef nonnull align 8 dereferenceable(152) ptr @__dynamic_cast(ptr nonnull %257, ptr nonnull @_ZTIN8QuantLib13Interpolation4ImplE, ptr nonnull @_ZTIN8QuantLib6detail17CoefficientHolderE, i64 -2) #28
   %c_.i555 = getelementptr inbounds nuw i8, ptr %258, i64 88
   %259 = load ptr, ptr %c_.i555, align 8, !tbaa !69
   %add.ptr.i556 = getelementptr inbounds nuw double, ptr %259, i64 %i624.01771
   %260 = load double, ptr %add.ptr.i556, align 8, !tbaa !70
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %257) ]
   %b_.i558 = getelementptr inbounds nuw i8, ptr %258, i64 64
   %261 = load ptr, ptr %b_.i558, align 8, !tbaa !69
   %add.ptr.i559 = getelementptr inbounds nuw double, ptr %261, i64 %i624.01771
   %262 = load double, ptr %add.ptr.i559, align 8, !tbaa !70
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %257) ]
   %a_.i561 = getelementptr inbounds nuw i8, ptr %258, i64 40
   %263 = load ptr, ptr %a_.i561, align 8, !tbaa !69
   %add.ptr.i562 = getelementptr inbounds nuw double, ptr %263, i64 %i624.01771
@@ -4393,7 +4404,8 @@ lpad664:                                          ; preds = %invoke.cont734, %in
   br label %ehcleanup755
 
 if.else692:                                       ; preds = %if.then660
-  %282 = load ptr, ptr %impl_.i.i554, align 8, !tbaa !167, !nonnull !27, !noundef !27
+  %282 = load ptr, ptr %impl_.i.i554, align 8, !tbaa !167
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %282) ]
   %283 = call noundef nonnull align 8 dereferenceable(152) ptr @__dynamic_cast(ptr nonnull %282, ptr nonnull @_ZTIN8QuantLib13Interpolation4ImplE, ptr nonnull @_ZTIN8QuantLib6detail17CoefficientHolderE, i64 -2) #28
   %c_.i577 = getelementptr inbounds nuw i8, ptr %283, i64 88
   %284 = load ptr, ptr %c_.i577, align 8, !tbaa !69
@@ -4402,10 +4414,12 @@ if.else692:                                       ; preds = %if.then660
 invoke.cont695:                                   ; preds = %if.else692
   %add.ptr.i579 = getelementptr inbounds nuw double, ptr %284, i64 %.lcssa1550
   %285 = load double, ptr %add.ptr.i579, align 8, !tbaa !70
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %282) ]
   %b_.i581 = getelementptr inbounds nuw i8, ptr %283, i64 64
   %286 = load ptr, ptr %b_.i581, align 8, !tbaa !69
   %add.ptr.i583 = getelementptr inbounds nuw double, ptr %286, i64 %.lcssa1550
   %287 = load double, ptr %add.ptr.i583, align 8, !tbaa !70
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %282) ]
   %a_.i585 = getelementptr inbounds nuw i8, ptr %283, i64 40
   %288 = load ptr, ptr %a_.i585, align 8, !tbaa !69
   %add.ptr.i587 = getelementptr inbounds nuw double, ptr %288, i64 %.lcssa1550
@@ -4426,9 +4440,11 @@ if.end731.thread:                                 ; preds = %invoke.cont695
 
 invoke.cont734:                                   ; preds = %if.else692
   %295 = load double, ptr %284, align 8, !tbaa !70
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %282) ]
   %b_.i598 = getelementptr inbounds nuw i8, ptr %283, i64 64
   %296 = load ptr, ptr %b_.i598, align 8, !tbaa !69
   %297 = load double, ptr %296, align 8, !tbaa !70
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %282) ]
   %a_.i601 = getelementptr inbounds nuw i8, ptr %283, i64 40
   %298 = load ptr, ptr %a_.i601, align 8, !tbaa !69
   %299 = load double, ptr %298, align 8, !tbaa !70
diff --git a/bench/quantlib/optimized/varianceswap.ll b/bench/quantlib/optimized/varianceswap.ll
index 2fb4cfda539..c63c2fb0155 100644
--- a/bench/quantlib/optimized/varianceswap.ll
+++ b/bench/quantlib/optimized/varianceswap.ll
@@ -1045,13 +1045,12 @@ unreachable:                                      ; preds = %invoke.cont13
 define void @_ZNK8QuantLib12VarianceSwap12fetchResultsEPKNS_13PricingEngine7resultsE(ptr noundef nonnull align 8 dereferenceable(152) %this, ptr noundef %r) unnamed_addr #6 align 2 {
 entry:
   tail call void @_ZNK8QuantLib10Instrument12fetchResultsEPKNS_13PricingEngine7resultsE(ptr noundef nonnull align 8 dereferenceable(104) %this, ptr noundef %r)
-  %0 = icmp ne ptr %r, null
-  tail call void @llvm.assume(i1 %0)
-  %1 = tail call ptr @__dynamic_cast(ptr nonnull %r, ptr nonnull @_ZTIN8QuantLib13PricingEngine7resultsE, ptr nonnull @_ZTIN8QuantLib12VarianceSwap7resultsE, i64 -1) #25
-  %variance = getelementptr inbounds nuw i8, ptr %1, i64 80
-  %2 = load double, ptr %variance, align 8, !tbaa !62
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %r) ]
+  %0 = tail call ptr @__dynamic_cast(ptr nonnull %r, ptr nonnull @_ZTIN8QuantLib13PricingEngine7resultsE, ptr nonnull @_ZTIN8QuantLib12VarianceSwap7resultsE, i64 -1) #25
+  %variance = getelementptr inbounds nuw i8, ptr %0, i64 80
+  %1 = load double, ptr %variance, align 8, !tbaa !62
   %variance_ = getelementptr inbounds nuw i8, ptr %this, i64 144
-  store double %2, ptr %variance_, align 8, !tbaa !57
+  store double %1, ptr %variance_, align 8, !tbaa !57
   ret void
 }
 
diff --git a/bench/quiche-rs/optimized/8qvxqomhv7zamn8arx2q9ya4o.ll b/bench/quiche-rs/optimized/8qvxqomhv7zamn8arx2q9ya4o.ll
index 4cadcd881d0..e7f0f911851 100644
--- a/bench/quiche-rs/optimized/8qvxqomhv7zamn8arx2q9ya4o.ll
+++ b/bench/quiche-rs/optimized/8qvxqomhv7zamn8arx2q9ya4o.ll
@@ -707,8 +707,9 @@ _ZN4core5alloc6layout6Layout6repeat17hfd062edb70f5ec8fE.exit.i: ; preds = %2
   br i1 %11, label %"_ZN5alloc7raw_vec20RawVecInner$LT$A$GT$14current_memory17h8357e2e2933c373fE.exit.i", label %12
 
 12:                                               ; preds = %_ZN4core5alloc6layout6Layout6repeat17hfd062edb70f5ec8fE.exit.i
-  %.val39.i = load ptr, ptr %10, align 8, !alias.scope !82, !nonnull !3, !noundef !3
+  %.val39.i = load ptr, ptr %10, align 8, !alias.scope !82
   %13 = mul nuw nsw i64 %5, 232
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val39.i) ]
   store ptr %.val39.i, ptr %3, align 8, !alias.scope !85, !noalias !82
   %.sroa.5.0..sroa_idx.i41.i = getelementptr inbounds nuw i8, ptr %3, i64 16
   store i64 %13, ptr %.sroa.5.0..sroa_idx.i41.i, align 8, !alias.scope !85, !noalias !82
@@ -766,8 +767,9 @@ _ZN4core5alloc6layout6Layout6repeat17hfd062edb70f5ec8fE.exit.i: ; preds = %2
   br i1 %11, label %"_ZN5alloc7raw_vec20RawVecInner$LT$A$GT$14current_memory17h8357e2e2933c373fE.exit.i", label %12
 
 12:                                               ; preds = %_ZN4core5alloc6layout6Layout6repeat17hfd062edb70f5ec8fE.exit.i
-  %.val39.i = load ptr, ptr %10, align 8, !alias.scope !89, !nonnull !3, !noundef !3
+  %.val39.i = load ptr, ptr %10, align 8, !alias.scope !89
   %13 = mul nuw nsw i64 %5, 168
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val39.i) ]
   store ptr %.val39.i, ptr %3, align 8, !alias.scope !92, !noalias !89
   %.sroa.5.0..sroa_idx.i41.i = getelementptr inbounds nuw i8, ptr %3, i64 16
   store i64 %13, ptr %.sroa.5.0..sroa_idx.i41.i, align 8, !alias.scope !92, !noalias !89
@@ -815,8 +817,9 @@ define hidden void @"_ZN5alloc7raw_vec20RawVecInner$LT$A$GT$10deallocate17hb0fd2
 
 6:                                                ; preds = %3
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 8
-  %.val1 = load ptr, ptr %7, align 8, !nonnull !3, !noundef !3
+  %.val1 = load ptr, ptr %7, align 8
   %8 = mul nuw i64 %.val, %2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1) ]
   tail call void @_RNvCshjvJWTf7CV5_7___rustc14___rust_dealloc(ptr noundef nonnull %.val1, i64 noundef %8, i64 noundef range(i64 1, -9223372036854775807) %1) #23
   br label %"_ZN63_$LT$alloc..alloc..Global$u20$as$u20$core..alloc..Allocator$GT$10deallocate17hbe0bed701c47e163E.exit"
 
@@ -933,8 +936,9 @@ _ZN4core5alloc6layout6Layout6repeat17hfd062edb70f5ec8fE.exit.i: ; preds = %12
   br i1 %29, label %"_ZN5alloc7raw_vec20RawVecInner$LT$A$GT$14current_memory17h8357e2e2933c373fE.exit.i", label %30
 
 30:                                               ; preds = %_ZN4core5alloc6layout6Layout6repeat17hfd062edb70f5ec8fE.exit.i
-  %.val39.i = load ptr, ptr %28, align 8, !alias.scope !95, !nonnull !3, !noundef !3
+  %.val39.i = load ptr, ptr %28, align 8, !alias.scope !95
   %31 = mul nuw i64 %14, %4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val39.i) ]
   store ptr %.val39.i, ptr %6, align 8, !alias.scope !98, !noalias !95
   %.sroa.5.0..sroa_idx.i41.i = getelementptr inbounds nuw i8, ptr %6, i64 16
   store i64 %31, ptr %.sroa.5.0..sroa_idx.i41.i, align 8, !alias.scope !98, !noalias !95
diff --git a/bench/quiche-rs/optimized/ef5wjav2twwy2d1ucao7uchw2.ll b/bench/quiche-rs/optimized/ef5wjav2twwy2d1ucao7uchw2.ll
index 85d4f8d66f2..fffacfec7ed 100644
--- a/bench/quiche-rs/optimized/ef5wjav2twwy2d1ucao7uchw2.ll
+++ b/bench/quiche-rs/optimized/ef5wjav2twwy2d1ucao7uchw2.ll
@@ -30,9 +30,10 @@ define hidden noundef i64 @"_ZN109_$LT$alloc..collections..vec_deque..iter..Iter
   %5 = alloca [8 x i8], align 8
   %6 = load ptr, ptr %0, align 8, !nonnull !3, !noundef !3
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 8
-  %8 = load ptr, ptr %7, align 8, !nonnull !3, !noundef !3
+  %8 = load ptr, ptr %7, align 8, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %5)
   store ptr %3, ptr %5, align 8, !noalias !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   %9 = icmp eq ptr %6, %8
   br i1 %9, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h649fa7f3d27dd9a2E.exit", label %10
 
@@ -58,9 +59,10 @@ define hidden noundef i64 @"_ZN109_$LT$alloc..collections..vec_deque..iter..Iter
   %20 = getelementptr inbounds nuw i8, ptr %0, i64 16
   %21 = load ptr, ptr %20, align 8, !nonnull !3, !noundef !3
   %22 = getelementptr inbounds nuw i8, ptr %0, i64 24
-  %23 = load ptr, ptr %22, align 8, !nonnull !3, !noundef !3
+  %23 = load ptr, ptr %22, align 8, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %4)
   store ptr %3, ptr %4, align 8, !noalias !7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %23) ]
   %24 = icmp eq ptr %21, %23
   br i1 %24, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h649fa7f3d27dd9a2E.exit4", label %25
 
@@ -93,9 +95,10 @@ define hidden noundef i64 @"_ZN109_$LT$alloc..collections..vec_deque..iter..Iter
   %5 = alloca [8 x i8], align 8
   %6 = load ptr, ptr %0, align 8, !nonnull !3, !noundef !3
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 8
-  %8 = load ptr, ptr %7, align 8, !nonnull !3, !noundef !3
+  %8 = load ptr, ptr %7, align 8, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %5)
   store ptr %3, ptr %5, align 8, !noalias !10
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   %9 = icmp eq ptr %6, %8
   br i1 %9, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h9d751ead39484ef2E.exit", label %10
 
@@ -121,9 +124,10 @@ define hidden noundef i64 @"_ZN109_$LT$alloc..collections..vec_deque..iter..Iter
   %20 = getelementptr inbounds nuw i8, ptr %0, i64 16
   %21 = load ptr, ptr %20, align 8, !nonnull !3, !noundef !3
   %22 = getelementptr inbounds nuw i8, ptr %0, i64 24
-  %23 = load ptr, ptr %22, align 8, !nonnull !3, !noundef !3
+  %23 = load ptr, ptr %22, align 8, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %4)
   store ptr %3, ptr %4, align 8, !noalias !13
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %23) ]
   %24 = icmp eq ptr %21, %23
   br i1 %24, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h9d751ead39484ef2E.exit4", label %25
 
@@ -156,9 +160,10 @@ define hidden noundef i64 @"_ZN109_$LT$alloc..collections..vec_deque..iter..Iter
   %5 = alloca [8 x i8], align 8
   %6 = load ptr, ptr %0, align 8, !nonnull !3, !noundef !3
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 8
-  %8 = load ptr, ptr %7, align 8, !nonnull !3, !noundef !3
+  %8 = load ptr, ptr %7, align 8, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %5)
   store ptr %3, ptr %5, align 8, !noalias !16
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   %9 = icmp eq ptr %6, %8
   br i1 %9, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17hef43fce312229576E.exit", label %10
 
@@ -184,9 +189,10 @@ define hidden noundef i64 @"_ZN109_$LT$alloc..collections..vec_deque..iter..Iter
   %20 = getelementptr inbounds nuw i8, ptr %0, i64 16
   %21 = load ptr, ptr %20, align 8, !nonnull !3, !noundef !3
   %22 = getelementptr inbounds nuw i8, ptr %0, i64 24
-  %23 = load ptr, ptr %22, align 8, !nonnull !3, !noundef !3
+  %23 = load ptr, ptr %22, align 8, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %4)
   store ptr %3, ptr %4, align 8, !noalias !19
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %23) ]
   %24 = icmp eq ptr %21, %23
   br i1 %24, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17hef43fce312229576E.exit4", label %25
 
@@ -307,10 +313,12 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h16389e01dc96481
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !30
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !30
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %10 = getelementptr inbounds nuw i8, ptr %1, i64 8
   %.val.i = load ptr, ptr %10, align 8, !noalias !33, !nonnull !3, !noundef !3
   %11 = getelementptr inbounds nuw i8, ptr %1, i64 16
   %.val1.i = load i64, ptr %11, align 8, !noalias !33, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !36
   store i64 %.val1.i, ptr %3, align 8, !noalias !36
   call fastcc void @"_ZN71_$LT$core..hash..sip..Hasher$LT$S$GT$$u20$as$u20$core..hash..Hasher$GT$5write17h7ba78031ab13fc7aE"(ptr noalias noundef nonnull align 8 dereferenceable(72) %4, ptr noalias noundef nonnull readonly align 1 %3, i64 noundef 8)
@@ -411,6 +419,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h1ad0e864dbef2a1
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !48
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %3, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !48
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   call void @"_ZN97_$LT$tokio_quiche..metrics..labels..QuicInvalidInitialPacketError$u20$as$u20$core..hash..Hash$GT$4hash17he8e12a64870240faE"(ptr noalias noundef nonnull readonly align 1 dereferenceable(1) %1, ptr noalias noundef nonnull align 8 dereferenceable(72) %3)
   %.sroa.0.0.copyload.i.i = load i64, ptr %3, align 8, !alias.scope !51
   %.sroa.10.0.copyload.i.i = load i64, ptr %.sroa.48.0..sroa_idx.i, align 8, !alias.scope !51
@@ -508,10 +517,12 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h1b27a0b97908d3a
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !56
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !56
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %10 = getelementptr inbounds nuw i8, ptr %1, i64 8
   %.val.i = load ptr, ptr %10, align 8, !noalias !59, !nonnull !3, !noundef !3
   %11 = getelementptr inbounds nuw i8, ptr %1, i64 16
   %.val1.i = load i64, ptr %11, align 8, !noalias !59, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   call fastcc void @"_ZN71_$LT$core..hash..sip..Hasher$LT$S$GT$$u20$as$u20$core..hash..Hasher$GT$5write17h7ba78031ab13fc7aE"(ptr noalias noundef nonnull align 8 dereferenceable(72) %4, ptr noalias noundef nonnull readonly align 1 %.val.i, i64 noundef %.val1.i)
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !62
   store i8 -1, ptr %3, align 1, !noalias !62
@@ -613,9 +624,11 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h349884ae6f8deae
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !81
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !81
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load ptr, ptr %1, align 8, !noalias !84, !nonnull !3, !noundef !3
   %10 = getelementptr inbounds nuw i8, ptr %1, i64 8
   %.val1.i = load i64, ptr %10, align 8, !noalias !84, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   %11 = getelementptr inbounds nuw i8, ptr %.val.i, i64 16
   call fastcc void @"_ZN71_$LT$core..hash..sip..Hasher$LT$S$GT$$u20$as$u20$core..hash..Hasher$GT$5write17h7ba78031ab13fc7aE"(ptr noalias noundef nonnull align 8 dereferenceable(72) %4, ptr noalias noundef nonnull readonly align 1 %11, i64 noundef %.val1.i)
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !87
@@ -720,6 +733,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h58a214004060624
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !104
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %6, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !104
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !107)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !110)
   %12 = getelementptr inbounds nuw i8, ptr %1, i64 17
@@ -848,6 +862,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h5a0d8effeefcad5
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !140
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !140
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i8, ptr %1, align 1, !range !116, !noalias !143, !noundef !3
   %10 = zext nneg i8 %.val.i to i64
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !146
@@ -950,6 +965,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h655a5ffc4b7255d
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !160
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !160
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i64, ptr %1, align 8, !noalias !163, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !166
   store i64 %.val.i, ptr %3, align 8, !noalias !166
@@ -1051,6 +1067,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h6d9fa23c89d4cf3
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !178
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !178
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i64, ptr %1, align 8, !noalias !181, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !184
   store i64 %.val.i, ptr %3, align 8, !noalias !184
@@ -1152,6 +1169,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h867b67c5d795194
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !196
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !196
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i64, ptr %1, align 8, !noalias !199, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !202
   store i64 %.val.i, ptr %3, align 8, !noalias !202
@@ -1253,9 +1271,11 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h96c975ae2cdab72
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !212
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !212
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load ptr, ptr %1, align 8, !noalias !215, !nonnull !3, !noundef !3
   %10 = getelementptr inbounds nuw i8, ptr %1, i64 8
   %.val1.i = load i64, ptr %10, align 8, !noalias !215, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   %11 = getelementptr inbounds nuw i8, ptr %.val.i, i64 16
   call fastcc void @"_ZN71_$LT$core..hash..sip..Hasher$LT$S$GT$$u20$as$u20$core..hash..Hasher$GT$5write17h7ba78031ab13fc7aE"(ptr noalias noundef nonnull align 8 dereferenceable(72) %4, ptr noalias noundef nonnull readonly align 1 %11, i64 noundef %.val1.i)
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !218
@@ -1358,6 +1378,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h9b0b8cc6f8ab2eb
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !235
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !235
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i8, ptr %1, align 1, !range !238, !noalias !239, !noundef !3
   %10 = zext nneg i8 %.val.i to i64
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !242
@@ -1460,6 +1481,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17haf7726d8f37142b
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !256
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !256
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i8, ptr %1, align 1, !range !259, !noalias !260, !noundef !3
   %10 = zext nneg i8 %.val.i to i64
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !263
@@ -1562,9 +1584,11 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17hb5ea6ee04e0a0ab
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !277
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !277
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load ptr, ptr %1, align 8, !noalias !280, !nonnull !3, !noundef !3
   %10 = getelementptr inbounds nuw i8, ptr %1, i64 8
   %.val1.i = load i64, ptr %10, align 8, !noalias !280, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   %11 = getelementptr inbounds nuw i8, ptr %.val.i, i64 16
   call fastcc void @"_ZN71_$LT$core..hash..sip..Hasher$LT$S$GT$$u20$as$u20$core..hash..Hasher$GT$5write17h7ba78031ab13fc7aE"(ptr noalias noundef nonnull align 8 dereferenceable(72) %4, ptr noalias noundef nonnull readonly align 1 %11, i64 noundef %.val1.i)
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !283
@@ -1667,6 +1691,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17hb894f5e3cd0868f
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !300
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !300
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i64, ptr %1, align 8, !noalias !303, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !306
   store i64 %.val.i, ptr %3, align 8, !noalias !306
@@ -1768,6 +1793,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17hc000e9e36c15750
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !316
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !316
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i64, ptr %1, align 8, !noalias !319, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !322
   store i64 %.val.i, ptr %3, align 8, !noalias !322
@@ -1869,6 +1895,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17hc5a5208e0d7a224
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !334
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !334
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i64, ptr %1, align 8, !noalias !337, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !340
   store i64 %.val.i, ptr %3, align 8, !noalias !340
@@ -1972,6 +1999,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17hf403354d36f8093
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !352
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %6, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !352
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !355)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !358)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !361)
@@ -3134,6 +3162,7 @@ _ZN4core4hash3sip9u8to64_le17hdbc674c1681e6e6fE.exit18: ; preds = %91, %93
 ; Function Attrs: nonlazybind uwtable
 define hidden noundef zeroext i1 @"_ZN72_$LT$core..pin..Pin$LT$P$GT$$u20$as$u20$core..future..future..Future$GT$4poll17h7ca37aa47d6afce9E"(ptr noalias noundef readonly align 8 captures(none) dereferenceable(8) %0, ptr noalias noundef align 8 dereferenceable(32) %1) unnamed_addr #0 {
   %.val = load ptr, ptr %0, align 8, !nonnull !3, !align !27, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %3 = tail call noundef zeroext i1 @"_ZN74_$LT$tokio..time..sleep..Sleep$u20$as$u20$core..future..future..Future$GT$4poll17hae5b2de500a97bfaE"(ptr noundef nonnull align 8 %.val, ptr noalias noundef nonnull align 8 dereferenceable(32) %1)
   ret i1 %3
 }
@@ -3176,6 +3205,7 @@ define hidden noundef ptr @"_ZN88_$LT$prometools..serde..top..StructSerializer$u
   %.val = load ptr, ptr %3, align 8, !nonnull !3, !noundef !3
   %21 = getelementptr inbounds nuw i8, ptr %3, i64 8
   %.val32 = load i64, ptr %21, align 8, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %22 = getelementptr inbounds nuw i8, ptr %.val, i64 16
   %23 = tail call noundef ptr @"_ZN84_$LT$prometools..serde..value..ValueSerializer$u20$as$u20$serde..ser..Serializer$GT$13serialize_str17hd407fed70cb2436eE"(ptr noundef nonnull align 1 %18, ptr noalias noundef nonnull readonly align 8 dereferenceable(80) %20, ptr noalias noundef nonnull readonly align 1 %22, i64 noundef %.val32)
   br label %24
@@ -3267,6 +3297,7 @@ define hidden noundef ptr @"_ZN88_$LT$prometools..serde..top..StructSerializer$u
   %.val = load ptr, ptr %21, align 8, !nonnull !3, !noundef !3
   %22 = getelementptr inbounds nuw i8, ptr %3, i64 16
   %.val32 = load i64, ptr %22, align 8, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %23 = tail call noundef ptr @"_ZN84_$LT$prometools..serde..value..ValueSerializer$u20$as$u20$serde..ser..Serializer$GT$13serialize_str17hd407fed70cb2436eE"(ptr noundef nonnull align 1 %18, ptr noalias noundef nonnull readonly align 8 dereferenceable(80) %20, ptr noalias noundef nonnull readonly align 1 %.val, i64 noundef %.val32)
   br label %24
 
@@ -3573,6 +3604,7 @@ define hidden noalias noundef ptr @"_ZN95_$LT$std..io..cursor..Cursor$LT$alloc..
 _ZN3std2io6cursor15reserve_and_pad17h6a89407623b28e46E.exit.i: ; preds = %18, %13
   %23 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %.val9.i = load ptr, ptr %23, align 8, !alias.scope !417, !noalias !424, !nonnull !3, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val9.i) ]
   %24 = getelementptr inbounds nuw i8, ptr %.val9.i, i64 %.val.i
   tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %24, ptr nonnull readonly align 1 %1, i64 %2, i1 false), !noalias !414
   %25 = add i64 %.val.i, %2
diff --git a/bench/quiche-rs/optimized/f0vxo8kdo04wz5kbvnjzws46n.ll b/bench/quiche-rs/optimized/f0vxo8kdo04wz5kbvnjzws46n.ll
index b220ee27b53..677833fdff4 100644
--- a/bench/quiche-rs/optimized/f0vxo8kdo04wz5kbvnjzws46n.ll
+++ b/bench/quiche-rs/optimized/f0vxo8kdo04wz5kbvnjzws46n.ll
@@ -271,9 +271,10 @@ define hidden noundef i64 @"_ZN109_$LT$alloc..collections..vec_deque..iter..Iter
   %5 = alloca [8 x i8], align 8
   %6 = load ptr, ptr %0, align 8, !nonnull !3, !noundef !3
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 8
-  %8 = load ptr, ptr %7, align 8, !nonnull !3, !noundef !3
+  %8 = load ptr, ptr %7, align 8, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %5)
   store ptr %3, ptr %5, align 8, !noalias !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   %9 = icmp eq ptr %6, %8
   br i1 %9, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h8bb7aaf3d4e5c8bcE.exit", label %10
 
@@ -299,9 +300,10 @@ define hidden noundef i64 @"_ZN109_$LT$alloc..collections..vec_deque..iter..Iter
   %20 = getelementptr inbounds nuw i8, ptr %0, i64 16
   %21 = load ptr, ptr %20, align 8, !nonnull !3, !noundef !3
   %22 = getelementptr inbounds nuw i8, ptr %0, i64 24
-  %23 = load ptr, ptr %22, align 8, !nonnull !3, !noundef !3
+  %23 = load ptr, ptr %22, align 8, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %4)
   store ptr %3, ptr %4, align 8, !noalias !7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %23) ]
   %24 = icmp eq ptr %21, %23
   br i1 %24, label %"_ZN91_$LT$core..slice..iter..Iter$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h8bb7aaf3d4e5c8bcE.exit4", label %25
 
@@ -708,6 +710,7 @@ define internal noundef zeroext i1 @"_ZN44_$LT$$RF$T$u20$as$u20$core..fmt..Displ
 define hidden { i64, i64 } @"_ZN4core3ops8function5impls79_$LT$impl$u20$core..ops..function..FnMut$LT$A$GT$$u20$for$u20$$RF$mut$u20$F$GT$8call_mut17h36cd24b3ca078315E"(ptr noalias noundef readonly align 8 captures(none) dereferenceable(8) %0, i64 noundef %1, ptr noalias noundef readonly align 8 dereferenceable(16) %2) unnamed_addr #0 {
   %4 = load ptr, ptr %0, align 8, !nonnull !3, !align !112, !noundef !3
   %.val = load ptr, ptr %4, align 8, !nonnull !3, !align !112, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = load ptr, ptr %.val, align 8, !noalias !113, !nonnull !3, !align !112, !noundef !3
   %6 = getelementptr inbounds nuw i8, ptr %5, i64 80
   %7 = load ptr, ptr %6, align 8, !noalias !113, !nonnull !3, !noundef !3
@@ -869,9 +872,12 @@ define internal fastcc noundef zeroext i1 @"_ZN4core3str7pattern13simd_contains2
 
 27:                                               ; preds = %26
   %28 = add i64 %.sroa.9.0.i.us, 1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %25) ]
   %29 = getelementptr inbounds nuw i8, ptr %25, i64 %.sroa.9.0.i.us
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %12) ]
   %30 = getelementptr inbounds nuw i8, ptr %12, i64 %.sroa.9.0.i.us
   %31 = load i8, ptr %29, align 1, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %30) ]
   %32 = load i8, ptr %30, align 1, !alias.scope !134, !noalias !131, !noundef !3
   %.not12.i.us = icmp eq i8 %31, %32
   br i1 %.not12.i.us, label %26, label %_ZN4core3str7pattern14small_slice_eq17h93367e4799060334E.exit.thread.loopexit.us
@@ -953,10 +959,12 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h93a854afdaeb285
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !144
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !144
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %10 = getelementptr inbounds nuw i8, ptr %1, i64 8
   %.val.i = load ptr, ptr %10, align 8, !noalias !147, !nonnull !3, !noundef !3
   %11 = getelementptr inbounds nuw i8, ptr %1, i64 16
   %.val1.i = load i64, ptr %11, align 8, !noalias !147, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !150
   store i64 %.val1.i, ptr %3, align 8, !noalias !150
   call fastcc void @"_ZN71_$LT$std..hash..random..DefaultHasher$u20$as$u20$core..hash..Hasher$GT$5write17h16e314fb9560002cE"(ptr noalias noundef nonnull align 8 dereferenceable(72) %4, ptr noalias noundef nonnull readonly align 1 %3, i64 noundef 8)
@@ -1058,6 +1066,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h97f7ef3dbadfbe6
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !162
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %5, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !162
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !165
   store i64 %2, ptr %4, align 8, !noalias !165
   call fastcc void @"_ZN71_$LT$std..hash..random..DefaultHasher$u20$as$u20$core..hash..Hasher$GT$5write17h16e314fb9560002cE"(ptr noalias noundef nonnull align 8 dereferenceable(72) %5, ptr noalias noundef nonnull readonly align 1 %4, i64 noundef 8), !noalias !175
@@ -1159,6 +1168,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17hac54f8c4e6feaef
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !181
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !181
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i64, ptr %1, align 8, !noalias !184, !noundef !3
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !187
   store i64 %.val.i, ptr %3, align 8, !noalias !187
@@ -1540,6 +1550,7 @@ define hidden noundef nonnull align 8 ptr @"_ZN61_$LT$serde_json..error..Error$u
   call void @llvm.lifetime.start.p0(ptr nonnull %4)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !201)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !204)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !207
   call void @"_ZN5alloc7raw_vec20RawVecInner$LT$A$GT$15try_allocate_in17hf2643b92c386aa41E"(ptr noalias noundef nonnull sret([24 x i8]) align 8 captures(none) dereferenceable(24) %3, i64 noundef %1, i1 noundef zeroext false, i64 noundef 1, i64 noundef 1), !noalias !207
   %5 = load i64, ptr %3, align 8, !range !108, !noalias !207, !noundef !3
@@ -1669,6 +1680,7 @@ define hidden noundef nonnull align 8 ptr @"_ZN62_$LT$serde_json..error..Error$u
   call void @llvm.lifetime.start.p0(ptr nonnull %4)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !262)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !265)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !268
   call void @"_ZN5alloc7raw_vec20RawVecInner$LT$A$GT$15try_allocate_in17hf2643b92c386aa41E"(ptr noalias noundef nonnull sret([24 x i8]) align 8 captures(none) dereferenceable(24) %3, i64 noundef %1, i1 noundef zeroext false, i64 noundef 1, i64 noundef 1), !noalias !268
   %5 = load i64, ptr %3, align 8, !range !108, !noalias !268, !noundef !3
@@ -1781,6 +1793,7 @@ define hidden void @"_ZN6quiche9range_buf17RangeBuf$LT$F$GT$9split_off17h98dbeae
 
 15:                                               ; preds = %3
   %.val = load ptr, ptr %1, align 8, !nonnull !3, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %16 = atomicrmw add ptr %.val, i64 1 monotonic, align 8
   %17 = icmp slt i64 %16, 0
   br i1 %17, label %18, label %19
@@ -3175,6 +3188,7 @@ _ZN4core3str7pattern13simd_contains17he2e01193d3743636E.exit.i: ; preds = %250,
   %93 = add nuw nsw i64 %74, 1
   %94 = icmp samesign ne i64 %93, %57
   tail call void @llvm.assume(i1 %94)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %90) ]
   %95 = load i8, ptr %90, align 1, !noalias !448, !noundef !3
   %96 = shl nuw nsw i32 %92, 6
   %97 = and i8 %95, 63
@@ -3192,6 +3206,7 @@ _ZN4core3str7pattern13simd_contains17he2e01193d3743636E.exit.i: ; preds = %250,
   %104 = add nuw nsw i64 %74, 2
   %105 = icmp samesign ne i64 %104, %57
   tail call void @llvm.assume(i1 %105)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %103) ]
   %106 = load i8, ptr %103, align 1, !noalias !448, !noundef !3
   %107 = shl nuw nsw i32 %98, 6
   %108 = and i8 %106, 63
@@ -3207,6 +3222,7 @@ _ZN4core3str7pattern13simd_contains17he2e01193d3743636E.exit.i: ; preds = %250,
   %115 = add nuw nsw i64 %74, 3
   %116 = icmp samesign ne i64 %115, %57
   tail call void @llvm.assume(i1 %116)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %114) ]
   %117 = load i8, ptr %114, align 1, !noalias !448, !noundef !3
   %118 = shl nuw nsw i32 %92, 18
   %119 = and i32 %118, 1835008
@@ -4542,8 +4558,11 @@ define hidden void @_ZN3h3i19encode_header_block17h83321b2f7ae84fbfE(ptr dead_on
 
 76:                                               ; preds = %74
   %77 = add i64 %75, 1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %73) ]
   %78 = getelementptr inbounds nuw i8, ptr %73, i64 %75
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %67) ]
   %79 = getelementptr inbounds nuw i8, ptr %67, i64 %75
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %79) ]
   %.val.i.i.i = load i8, ptr %78, align 1, !noalias !580, !noundef !3
   %.val5.i.i.i = load i8, ptr %79, align 1, !noalias !580, !noundef !3
   %80 = add i8 %.val5.i.i.i, -65
diff --git a/bench/quinn-rs/optimized/94z0rmq3mlh67s9f6xgkqgoqb.ll b/bench/quinn-rs/optimized/94z0rmq3mlh67s9f6xgkqgoqb.ll
index 44c22b01271..e0eedb6daa0 100644
--- a/bench/quinn-rs/optimized/94z0rmq3mlh67s9f6xgkqgoqb.ll
+++ b/bench/quinn-rs/optimized/94z0rmq3mlh67s9f6xgkqgoqb.ll
@@ -56,6 +56,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %3 = alloca [8 x i8], align 8
   %4 = load ptr, ptr %0, align 8, !nonnull !3, !align !4, !noundef !3
   %.val = load ptr, ptr %4, align 8, !nonnull !3, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !5
   store ptr %.val, ptr %3, align 8, !noalias !5
   %5 = call noundef zeroext i1 @"_ZN54_$LT$$BP$const$u20$T$u20$as$u20$core..fmt..Pointer$GT$3fmt17h0f8d257a9ce4c8b8E"(ptr noalias noundef nonnull readonly align 8 dereferenceable(8) %3, ptr noalias noundef nonnull align 8 dereferenceable(24) %1)
@@ -67,6 +68,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
 define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$GT$3fmt17hec414442bf54fec9E"(ptr noalias noundef readonly align 8 captures(none) dereferenceable(8) %0, ptr noalias noundef align 8 dereferenceable(24) %1) unnamed_addr #0 {
   %3 = load ptr, ptr %0, align 8, !nonnull !3, !align !4, !noundef !3
   %.val = load ptr, ptr %3, align 8, !nonnull !3, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %4 = getelementptr inbounds nuw i8, ptr %.val, i64 16
   %5 = tail call noundef zeroext i1 @"_ZN86_$LT$tokio..runtime..scheduler..current_thread..Handle$u20$as$u20$core..fmt..Debug$GT$3fmt17h89ff6ac5f5a15ff2E"(ptr noundef nonnull align 8 %4, ptr noalias noundef nonnull align 8 dereferenceable(24) %1)
   ret i1 %5
@@ -380,8 +382,7 @@ define hidden noundef nonnull align 8 dereferenceable(16) ptr @_ZN4core3fmt8buil
   call void @llvm.lifetime.start.p0(ptr nonnull %4)
   store ptr %8, ptr %4, align 8
   call void @llvm.lifetime.start.p0(ptr nonnull %3)
-  %11 = icmp ne ptr %10, null
-  call void @llvm.assume(i1 %11)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %10) ]
   store ptr %10, ptr %3, align 8
   %12 = call noundef align 8 dereferenceable(16) ptr @_ZN4core3fmt8builders8DebugMap5entry17hada7ef8221dc89edE(ptr noalias noundef nonnull align 8 dereferenceable(16) %0, ptr noundef nonnull align 1 %4, ptr noalias noundef readonly align 8 dereferenceable(32) @anon.d16563b45468e483725d44465c1d4f32.7, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(32) @anon.d16563b45468e483725d44465c1d4f32.8)
   call void @llvm.lifetime.end.p0(ptr nonnull %3)
@@ -440,11 +441,13 @@ define hidden noundef nonnull align 8 dereferenceable(16) ptr @_ZN4core3fmt8buil
   ret ptr %0
 }
 
-; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read) uwtable
+; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: write) uwtable
 define hidden noundef range(i64 0, 1152921504606846976) i64 @_ZN4core4iter8adapters3zip27TrustedRandomAccessNoCoerce4size17h05245f1b60dba1daE(ptr noalias noundef readonly align 8 captures(none) dereferenceable(16) %0) unnamed_addr #1 {
   %.val = load ptr, ptr %0, align 8, !nonnull !3, !noundef !3
   %2 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %.val1 = load ptr, ptr %2, align 8, !nonnull !3, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %3 = ptrtoint ptr %.val1 to i64
   %4 = ptrtoint ptr %.val to i64
   %5 = sub nuw i64 %3, %4
@@ -452,11 +455,13 @@ define hidden noundef range(i64 0, 1152921504606846976) i64 @_ZN4core4iter8adapt
   ret i64 %6
 }
 
-; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read) uwtable
+; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: write) uwtable
 define hidden noundef range(i64 0, 256204778801521551) i64 @_ZN4core4iter8adapters3zip27TrustedRandomAccessNoCoerce4size17h3c4fe4c0ac4c4c04E(ptr noalias noundef readonly align 8 captures(none) dereferenceable(16) %0) unnamed_addr #1 {
   %.val = load ptr, ptr %0, align 8, !nonnull !3, !noundef !3
   %2 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %.val1 = load ptr, ptr %2, align 8, !nonnull !3, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %3 = ptrtoint ptr %.val1 to i64
   %4 = ptrtoint ptr %.val to i64
   %5 = sub nuw i64 %3, %4
@@ -483,6 +488,7 @@ define hidden void @"_ZN5alloc11collections5btree3map25IntoIter$LT$K$C$V$C$A$GT$
 10:                                               ; preds = %8
   %.sroa.2.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 8
   %.sroa.2.0.copyload.i = load i64, ptr %.sroa.2.0..sroa_idx.i, align 8, !noalias !22
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %9) ]
   %11 = load ptr, ptr %9, align 8, !noalias !25, !noundef !3
   %.not.i.i4.i.i = icmp eq ptr %11, null
   br i1 %.not.i.i4.i.i, label %"_ZN5alloc11collections5btree8navigate263_$LT$impl$u20$alloc..collections..btree..node..Handle$LT$alloc..collections..btree..node..NodeRef$LT$alloc..collections..btree..node..marker..Dying$C$K$C$V$C$alloc..collections..btree..node..marker..Leaf$GT$$C$alloc..collections..btree..node..marker..Edge$GT$$GT$16deallocating_end17h6423e49bbc7095ceE.exit.i", label %.lr.ph.i.i
@@ -642,6 +648,7 @@ define hidden void @"_ZN5alloc11collections5btree3map25IntoIter$LT$K$C$V$C$A$GT$
 10:                                               ; preds = %8
   %.sroa.2.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 8
   %.sroa.2.0.copyload.i = load i64, ptr %.sroa.2.0..sroa_idx.i, align 8, !noalias !58
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %9) ]
   %11 = load ptr, ptr %9, align 8, !noalias !61, !noundef !3
   %.not.i.i4.i.i = icmp eq ptr %11, null
   br i1 %.not.i.i4.i.i, label %"_ZN5alloc11collections5btree8navigate263_$LT$impl$u20$alloc..collections..btree..node..Handle$LT$alloc..collections..btree..node..NodeRef$LT$alloc..collections..btree..node..marker..Dying$C$K$C$V$C$alloc..collections..btree..node..marker..Leaf$GT$$C$alloc..collections..btree..node..marker..Edge$GT$$GT$16deallocating_end17hf21932443fedf91cE.exit.i", label %.lr.ph.i.i
@@ -1302,7 +1309,7 @@ declare void @llvm.lifetime.end.p0(ptr captures(none)) #9
 declare void @llvm.experimental.noalias.scope.decl(metadata) #10
 
 attributes #0 = { nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #1 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #1 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: write) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #2 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(read, inaccessiblemem: write, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #3 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
 attributes #4 = { nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
diff --git a/bench/raft-rs/optimized/co15qijodcfgouonod77sxo2v.ll b/bench/raft-rs/optimized/co15qijodcfgouonod77sxo2v.ll
index 6b12b8d7540..d76830d8ebe 100644
--- a/bench/raft-rs/optimized/co15qijodcfgouonod77sxo2v.ll
+++ b/bench/raft-rs/optimized/co15qijodcfgouonod77sxo2v.ll
@@ -40,6 +40,7 @@ target triple = "x86_64-unknown-linux-gnu"
 
 ; Function Attrs: nonlazybind uwtable
 define hidden void @_ZN3std3env3var17h1aa5320d34507570E(ptr dead_on_unwind noalias noundef writable sret([32 x i8]) align 8 captures(none) dereferenceable(32) %0, ptr noalias noundef nonnull readonly align 1 %1, i64 noundef %2) unnamed_addr #0 personality ptr @rust_eh_personality {
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   tail call void @_ZN3std3env4_var17hab6bfcdd7c8600aeE(ptr noalias noundef nonnull sret([32 x i8]) align 8 captures(none) dereferenceable(32) %0, ptr noalias noundef nonnull readonly align 1 %1, i64 noundef %2)
   ret void
 }
@@ -575,6 +576,7 @@ define hidden void @_ZN5alloc3str17join_generic_copy17ha626a64902a2a2f3E(ptr dea
   %.val = load ptr, ptr %56, align 8, !nonnull !3, !noundef !3
   %57 = getelementptr i8, ptr %1, i64 16
   %.val90 = load i64, ptr %57, align 8, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %58 = getelementptr inbounds nuw i8, ptr %.val, i64 %.val90
   invoke void @"_ZN132_$LT$alloc..vec..Vec$LT$T$C$A$GT$$u20$as$u20$alloc..vec..spec_extend..SpecExtend$LT$$RF$T$C$core..slice..iter..Iter$LT$T$GT$$GT$$GT$11spec_extend17hf7bf2c8c90fc11c6E"(ptr noalias noundef nonnull align 8 dereferenceable(24) %18, ptr noundef nonnull %.val, ptr noundef nonnull %58, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.248a150cfb6d17530aed19b80d6c6424.26)
           to label %59 unwind label %49
@@ -625,8 +627,11 @@ define hidden void @_ZN5alloc3str17join_generic_copy17ha626a64902a2a2f3E(ptr dea
   %.sroa.06.1321 = phi ptr [ %71, %"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$15copy_from_slice17h44bff27bd06e0be4E.exit108" ], [ %63, %.preheader279 ]
   %.sroa.27.1320 = phi i64 [ %72, %"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$15copy_from_slice17h44bff27bd06e0be4E.exit108" ], [ %64, %.preheader279 ]
   %.sroa.0153.0319 = phi ptr [ %70, %"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$15copy_from_slice17h44bff27bd06e0be4E.exit108" ], [ %22, %.preheader279 ]
-  %67 = getelementptr i8, ptr %.sroa.0153.0319, i64 16
-  %.val92 = load i64, ptr %67, align 8, !noundef !3
+  %67 = getelementptr i8, ptr %.sroa.0153.0319, i64 8
+  %.val92 = load ptr, ptr %67, align 8, !nonnull !3, !noundef !3
+  %68 = getelementptr i8, ptr %.sroa.0153.0319, i64 16
+  %.val92 = load i64, ptr %68, align 8, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val91) ]
   %.not85 = icmp ugt i64 %.val92, %.sroa.27.1320
   br i1 %.not85, label %68, label %"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$15copy_from_slice17h44bff27bd06e0be4E.exit108", !prof !37
 
@@ -635,8 +640,6 @@ define hidden void @_ZN5alloc3str17join_generic_copy17ha626a64902a2a2f3E(ptr dea
   br label %.invoke
 
 "_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$15copy_from_slice17h44bff27bd06e0be4E.exit108": ; preds = %.lr.ph322
-  %69 = getelementptr i8, ptr %.sroa.0153.0319, i64 8
-  %.val91 = load ptr, ptr %69, align 8, !nonnull !3, !noundef !3
   %70 = getelementptr inbounds nuw i8, ptr %.sroa.0153.0319, i64 24
   %71 = getelementptr inbounds nuw i8, ptr %.sroa.06.1321, i64 %.val92
   %72 = sub nuw i64 %.sroa.27.1320, %.val92
@@ -653,6 +656,7 @@ define hidden void @_ZN5alloc3str17join_generic_copy17ha626a64902a2a2f3E(ptr dea
   %.val93 = load ptr, ptr %75, align 8, !nonnull !3, !noundef !3
   %76 = getelementptr i8, ptr %.sroa.0154.0314, i64 16
   %.val94 = load i64, ptr %76, align 8, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val93) ]
   %.not81 = icmp eq i64 %.sroa.27.2315, 0
   br i1 %.not81, label %77, label %78, !prof !37
 
@@ -688,6 +692,7 @@ define hidden void @_ZN5alloc3str17join_generic_copy17ha626a64902a2a2f3E(ptr dea
   %.val95 = load ptr, ptr %87, align 8, !nonnull !3, !noundef !3
   %88 = getelementptr i8, ptr %.sroa.0156.0309, i64 16
   %.val96 = load i64, ptr %88, align 8, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val95) ]
   %89 = icmp ugt i64 %.sroa.27.3310, 1
   br i1 %89, label %91, label %90, !prof !86
 
@@ -723,6 +728,7 @@ define hidden void @_ZN5alloc3str17join_generic_copy17ha626a64902a2a2f3E(ptr dea
   %.val97 = load ptr, ptr %100, align 8, !nonnull !3, !noundef !3
   %101 = getelementptr i8, ptr %.sroa.0158.0304, i64 16
   %.val98 = load i64, ptr %101, align 8, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val97) ]
   %102 = icmp ugt i64 %.sroa.27.4305, 2
   br i1 %102, label %104, label %103, !prof !86
 
@@ -757,6 +763,7 @@ define hidden void @_ZN5alloc3str17join_generic_copy17ha626a64902a2a2f3E(ptr dea
   %.val99 = load ptr, ptr %112, align 8, !nonnull !3, !noundef !3
   %113 = getelementptr i8, ptr %.sroa.0160.0301, i64 16
   %.val100 = load i64, ptr %113, align 8, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val99) ]
   %114 = icmp ugt i64 %.sroa.27.5302, 3
   br i1 %114, label %116, label %115, !prof !86
 
@@ -792,6 +799,7 @@ define hidden void @_ZN5alloc3str17join_generic_copy17ha626a64902a2a2f3E(ptr dea
   %.val101 = load ptr, ptr %125, align 8, !nonnull !3, !noundef !3
   %126 = getelementptr i8, ptr %.sroa.0162.0324, i64 16
   %.val102 = load i64, ptr %126, align 8, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val101) ]
   %.not88 = icmp ugt i64 %4, %.sroa.27.0325
   br i1 %.not88, label %127, label %128, !prof !37
 
@@ -801,6 +809,7 @@ define hidden void @_ZN5alloc3str17join_generic_copy17ha626a64902a2a2f3E(ptr dea
 
 128:                                              ; preds = %.lr.ph327
   %129 = sub nuw i64 %.sroa.27.0325, %4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.06.0326) ]
   call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %.sroa.06.0326, ptr nonnull readonly align 1 %3, i64 %4, i1 false), !alias.scope !111
   %.not89 = icmp ugt i64 %.val102, %129
   br i1 %.not89, label %130, label %"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$15copy_from_slice17h44bff27bd06e0be4E.exit148", !prof !37
@@ -810,11 +819,11 @@ define hidden void @_ZN5alloc3str17join_generic_copy17ha626a64902a2a2f3E(ptr dea
   br label %.invoke
 
 .invoke:                                          ; preds = %68, %77, %81, %90, %94, %103, %106, %115, %119, %127, %130
-  %.sink.sroa.phi = phi ptr [ %.sink.sroa.gep, %68 ], [ %.sink.sroa.gep391, %77 ], [ %.sink.sroa.gep392, %81 ], [ %.sink.sroa.gep393, %90 ], [ %.sink.sroa.gep394, %94 ], [ %.sink.sroa.gep395, %103 ], [ %.sink.sroa.gep396, %106 ], [ %.sink.sroa.gep397, %115 ], [ %.sink.sroa.gep398, %119 ], [ %.sink.sroa.gep399, %127 ], [ %.sink.sroa.gep400, %130 ]
-  %.sink.sroa.phi401 = phi ptr [ %.sink.sroa.gep402, %68 ], [ %.sink.sroa.gep403, %77 ], [ %.sink.sroa.gep404, %81 ], [ %.sink.sroa.gep405, %90 ], [ %.sink.sroa.gep406, %94 ], [ %.sink.sroa.gep407, %103 ], [ %.sink.sroa.gep408, %106 ], [ %.sink.sroa.gep409, %115 ], [ %.sink.sroa.gep410, %119 ], [ %.sink.sroa.gep411, %127 ], [ %.sink.sroa.gep412, %130 ]
-  %.sink.sroa.phi413 = phi ptr [ %.sink.sroa.gep414, %68 ], [ %.sink.sroa.gep415, %77 ], [ %.sink.sroa.gep416, %81 ], [ %.sink.sroa.gep417, %90 ], [ %.sink.sroa.gep418, %94 ], [ %.sink.sroa.gep419, %103 ], [ %.sink.sroa.gep420, %106 ], [ %.sink.sroa.gep421, %115 ], [ %.sink.sroa.gep422, %119 ], [ %.sink.sroa.gep423, %127 ], [ %.sink.sroa.gep424, %130 ]
-  %.sink.sroa.phi425 = phi ptr [ %.sink.sroa.gep426, %68 ], [ %.sink.sroa.gep427, %77 ], [ %.sink.sroa.gep428, %81 ], [ %.sink.sroa.gep429, %90 ], [ %.sink.sroa.gep430, %94 ], [ %.sink.sroa.gep431, %103 ], [ %.sink.sroa.gep432, %106 ], [ %.sink.sroa.gep433, %115 ], [ %.sink.sroa.gep434, %119 ], [ %.sink.sroa.gep435, %127 ], [ %.sink.sroa.gep436, %130 ]
-  %.sink = phi ptr [ %17, %68 ], [ %16, %77 ], [ %15, %81 ], [ %14, %90 ], [ %13, %94 ], [ %12, %103 ], [ %11, %106 ], [ %10, %115 ], [ %9, %119 ], [ %8, %127 ], [ %7, %130 ]
+  %.sink.sroa.phi = phi ptr [ %.sink.sroa.gep, %69 ], [ %.sink.sroa.gep391, %77 ], [ %.sink.sroa.gep392, %81 ], [ %.sink.sroa.gep393, %90 ], [ %.sink.sroa.gep394, %94 ], [ %.sink.sroa.gep395, %103 ], [ %.sink.sroa.gep396, %106 ], [ %.sink.sroa.gep397, %115 ], [ %.sink.sroa.gep398, %119 ], [ %.sink.sroa.gep399, %127 ], [ %.sink.sroa.gep400, %130 ]
+  %.sink.sroa.phi401 = phi ptr [ %.sink.sroa.gep402, %69 ], [ %.sink.sroa.gep403, %77 ], [ %.sink.sroa.gep404, %81 ], [ %.sink.sroa.gep405, %90 ], [ %.sink.sroa.gep406, %94 ], [ %.sink.sroa.gep407, %103 ], [ %.sink.sroa.gep408, %106 ], [ %.sink.sroa.gep409, %115 ], [ %.sink.sroa.gep410, %119 ], [ %.sink.sroa.gep411, %127 ], [ %.sink.sroa.gep412, %130 ]
+  %.sink.sroa.phi413 = phi ptr [ %.sink.sroa.gep414, %69 ], [ %.sink.sroa.gep415, %77 ], [ %.sink.sroa.gep416, %81 ], [ %.sink.sroa.gep417, %90 ], [ %.sink.sroa.gep418, %94 ], [ %.sink.sroa.gep419, %103 ], [ %.sink.sroa.gep420, %106 ], [ %.sink.sroa.gep421, %115 ], [ %.sink.sroa.gep422, %119 ], [ %.sink.sroa.gep423, %127 ], [ %.sink.sroa.gep424, %130 ]
+  %.sink.sroa.phi425 = phi ptr [ %.sink.sroa.gep426, %69 ], [ %.sink.sroa.gep427, %77 ], [ %.sink.sroa.gep428, %81 ], [ %.sink.sroa.gep429, %90 ], [ %.sink.sroa.gep430, %94 ], [ %.sink.sroa.gep431, %103 ], [ %.sink.sroa.gep432, %106 ], [ %.sink.sroa.gep433, %115 ], [ %.sink.sroa.gep434, %119 ], [ %.sink.sroa.gep435, %127 ], [ %.sink.sroa.gep436, %130 ]
+  %.sink = phi ptr [ %17, %69 ], [ %16, %77 ], [ %15, %81 ], [ %14, %90 ], [ %13, %94 ], [ %12, %103 ], [ %11, %106 ], [ %10, %115 ], [ %9, %119 ], [ %8, %127 ], [ %7, %130 ]
   store ptr @anon.248a150cfb6d17530aed19b80d6c6424.18, ptr %.sink, align 8
   store i64 1, ptr %.sink.sroa.phi, align 8
   store ptr null, ptr %.sink.sroa.phi401, align 8
diff --git a/bench/rayon-rs/optimized/3gtpnk30hls61mxx.ll b/bench/rayon-rs/optimized/3gtpnk30hls61mxx.ll
index 663dd38b664..f21122cb1b2 100644
--- a/bench/rayon-rs/optimized/3gtpnk30hls61mxx.ll
+++ b/bench/rayon-rs/optimized/3gtpnk30hls61mxx.ll
@@ -64,7 +64,7 @@ _ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit: ; preds = %12, %16
   br i1 %23, label %28, label %24
 
 24:                                               ; preds = %"_ZN4core3str21_$LT$impl$u20$str$GT$16is_char_boundary17ha20072214ca7ea98E.exit.i", %19
-  call void @_ZN4core3str16slice_error_fail17hae3b26614aa3049fE(ptr noalias noundef nonnull readonly align 1 %1, i64 noundef %2, i64 noundef 0, i64 noundef range(i64 1, 0) %.0.i, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.3d131fa51848d5b1ae8500cd42c0b3a9.1) #6, !noalias !12
+  call void @_ZN4core3str16slice_error_fail17hae3b26614aa3049fE(ptr noalias noundef nonnull readonly align 1 %1, i64 noundef %2, i64 noundef 0, i64 noundef range(i64 1, 0) %.0.i, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.3d131fa51848d5b1ae8500cd42c0b3a9.1) #7, !noalias !12
   unreachable
 
 25:                                               ; preds = %_ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit, %_ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit.thread
@@ -78,6 +78,7 @@ _ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit: ; preds = %12, %16
 28:                                               ; preds = %19, %"_ZN4core3str21_$LT$impl$u20$str$GT$16is_char_boundary17ha20072214ca7ea98E.exit.i"
   %29 = getelementptr inbounds i8, ptr %1, i64 %.0.i
   %30 = sub i64 %2, %.0.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %29) ]
   store ptr %1, ptr %0, align 8
   %31 = getelementptr inbounds nuw i8, ptr %0, i64 8
   store i64 %.0.i, ptr %31, align 8
@@ -152,7 +153,7 @@ _ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit: ; preds = %14, %18
   br i1 %25, label %29, label %26
 
 26:                                               ; preds = %"_ZN4core3str21_$LT$impl$u20$str$GT$16is_char_boundary17ha20072214ca7ea98E.exit.i", %21
-  call void @_ZN4core3str16slice_error_fail17hae3b26614aa3049fE(ptr noalias noundef nonnull readonly align 1 %5, i64 noundef %7, i64 noundef 0, i64 noundef range(i64 1, 0) %.0.i, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.3d131fa51848d5b1ae8500cd42c0b3a9.1) #6, !noalias !24
+  call void @_ZN4core3str16slice_error_fail17hae3b26614aa3049fE(ptr noalias noundef nonnull readonly align 1 %5, i64 noundef %7, i64 noundef 0, i64 noundef range(i64 1, 0) %.0.i, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.3d131fa51848d5b1ae8500cd42c0b3a9.1) #7, !noalias !24
   unreachable
 
 27:                                               ; preds = %_ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit, %_ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit.thread
@@ -164,6 +165,7 @@ _ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit: ; preds = %14, %18
 29:                                               ; preds = %21, %"_ZN4core3str21_$LT$impl$u20$str$GT$16is_char_boundary17ha20072214ca7ea98E.exit.i"
   %30 = getelementptr inbounds i8, ptr %5, i64 %.0.i
   %31 = sub i64 %7, %.0.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %30) ]
   %32 = getelementptr inbounds nuw i8, ptr %1, i64 16
   %33 = load i64, ptr %32, align 8, !noundef !14
   %34 = add i64 %33, %.0.i
@@ -242,7 +244,7 @@ _ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit: ; preds = %12, %16
   br i1 %23, label %28, label %24
 
 24:                                               ; preds = %"_ZN4core3str21_$LT$impl$u20$str$GT$16is_char_boundary17ha20072214ca7ea98E.exit.i", %19
-  call void @_ZN4core3str16slice_error_fail17hae3b26614aa3049fE(ptr noalias noundef nonnull readonly align 1 %1, i64 noundef %2, i64 noundef 0, i64 noundef range(i64 1, 0) %.0.i, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.3d131fa51848d5b1ae8500cd42c0b3a9.1) #6, !noalias !34
+  call void @_ZN4core3str16slice_error_fail17hae3b26614aa3049fE(ptr noalias noundef nonnull readonly align 1 %1, i64 noundef %2, i64 noundef 0, i64 noundef range(i64 1, 0) %.0.i, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.3d131fa51848d5b1ae8500cd42c0b3a9.1) #7, !noalias !34
   unreachable
 
 25:                                               ; preds = %_ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit, %_ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit.thread
@@ -256,6 +258,7 @@ _ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit: ; preds = %12, %16
 28:                                               ; preds = %19, %"_ZN4core3str21_$LT$impl$u20$str$GT$16is_char_boundary17ha20072214ca7ea98E.exit.i"
   %29 = getelementptr inbounds i8, ptr %1, i64 %.0.i
   %30 = sub i64 %2, %.0.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %29) ]
   store ptr %1, ptr %0, align 8
   %31 = getelementptr inbounds nuw i8, ptr %0, i64 8
   store i64 %.0.i, ptr %31, align 8
@@ -327,7 +330,7 @@ _ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit: ; preds = %12, %16
   br i1 %23, label %28, label %24
 
 24:                                               ; preds = %"_ZN4core3str21_$LT$impl$u20$str$GT$16is_char_boundary17ha20072214ca7ea98E.exit.i", %19
-  call void @_ZN4core3str16slice_error_fail17hae3b26614aa3049fE(ptr noalias noundef nonnull readonly align 1 %1, i64 noundef %2, i64 noundef 0, i64 noundef range(i64 1, 0) %.0.i, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.3d131fa51848d5b1ae8500cd42c0b3a9.1) #6, !noalias !44
+  call void @_ZN4core3str16slice_error_fail17hae3b26614aa3049fE(ptr noalias noundef nonnull readonly align 1 %1, i64 noundef %2, i64 noundef 0, i64 noundef range(i64 1, 0) %.0.i, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.3d131fa51848d5b1ae8500cd42c0b3a9.1) #7, !noalias !44
   unreachable
 
 25:                                               ; preds = %_ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit, %_ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit.thread
@@ -341,6 +344,7 @@ _ZN5rayon3str18find_char_midpoint17h6911442dcb4bfac0E.exit: ; preds = %12, %16
 28:                                               ; preds = %19, %"_ZN4core3str21_$LT$impl$u20$str$GT$16is_char_boundary17ha20072214ca7ea98E.exit.i"
   %29 = getelementptr inbounds i8, ptr %1, i64 %.0.i
   %30 = sub i64 %2, %.0.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %29) ]
   store ptr %1, ptr %0, align 8
   %31 = getelementptr inbounds nuw i8, ptr %0, i64 8
   store i64 %.0.i, ptr %31, align 8
@@ -364,6 +368,9 @@ define void @"_ZN5rayon3str77_$LT$impl$u20$rayon..str..private..Pattern$u20$for$
   ret void
 }
 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #2
+
 ; Function Attrs: cold noreturn nonlazybind uwtable
 declare void @_ZN4core3str16slice_error_fail17hae3b26614aa3049fE(ptr noalias noundef nonnull readonly align 1, i64 noundef, i64 noundef, i64 noundef, ptr noalias noundef readonly align 8 dereferenceable(24)) unnamed_addr #2
 
@@ -387,11 +394,12 @@ declare void @llvm.lifetime.end.p0(ptr captures(none)) #5
 
 attributes #0 = { nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #1 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #2 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #3 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
-attributes #4 = { inlinehint nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #5 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
-attributes #6 = { noreturn }
+attributes #2 = { mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #3 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #4 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
+attributes #5 = { inlinehint nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #6 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
+attributes #7 = { noreturn }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/rayon-rs/optimized/4ho2e9t13rrkhaa8.ll b/bench/rayon-rs/optimized/4ho2e9t13rrkhaa8.ll
index ac804a543f7..c1c1c8567ae 100644
--- a/bench/rayon-rs/optimized/4ho2e9t13rrkhaa8.ll
+++ b/bench/rayon-rs/optimized/4ho2e9t13rrkhaa8.ll
@@ -14,32 +14,31 @@ target triple = "x86_64-unknown-linux-gnu"
 
 ; Function Attrs: nonlazybind uwtable
 define hidden void @"_ZN132_$LT$alloc..vec..Vec$LT$T$C$A$GT$$u20$as$u20$alloc..vec..spec_extend..SpecExtend$LT$$RF$T$C$core..slice..iter..Iter$LT$T$GT$$GT$$GT$11spec_extend17ha43a06245ab7360bE.llvm.10518328448262610784"(ptr noalias noundef align 8 dereferenceable(24) %0, ptr noundef nonnull %1, ptr noundef %2) unnamed_addr #0 {
-  %4 = icmp ne ptr %2, null
-  tail call void @llvm.assume(i1 %4)
-  %5 = ptrtoint ptr %2 to i64
-  %6 = ptrtoint ptr %1 to i64
-  %7 = sub nuw i64 %5, %6
-  %8 = getelementptr inbounds nuw i8, ptr %0, i64 16
-  %9 = load i64, ptr %8, align 8, !alias.scope !4, !noundef !7
-  %10 = load i64, ptr %0, align 8, !alias.scope !4, !noundef !7
-  %11 = sub i64 %10, %9
-  %12 = icmp ugt i64 %7, %11
-  br i1 %12, label %13, label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h9143d68ca1389f62E.llvm.10518328448262610784.exit"
-
-13:                                               ; preds = %3
-  tail call void @"_ZN5alloc7raw_vec19RawVec$LT$T$C$A$GT$7reserve21do_reserve_and_handle17h006f831228e4b58bE"(ptr noalias noundef nonnull align 8 dereferenceable(24) %0, i64 noundef %9, i64 noundef %7)
-  %.pre = load i64, ptr %8, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  %4 = ptrtoint ptr %2 to i64
+  %5 = ptrtoint ptr %1 to i64
+  %6 = sub nuw i64 %4, %5
+  %7 = getelementptr inbounds nuw i8, ptr %0, i64 16
+  %8 = load i64, ptr %7, align 8, !alias.scope !4, !noundef !7
+  %9 = load i64, ptr %0, align 8, !alias.scope !4, !noundef !7
+  %10 = sub i64 %9, %8
+  %11 = icmp ugt i64 %6, %10
+  br i1 %11, label %12, label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h9143d68ca1389f62E.llvm.10518328448262610784.exit"
+
+12:                                               ; preds = %3
+  tail call void @"_ZN5alloc7raw_vec19RawVec$LT$T$C$A$GT$7reserve21do_reserve_and_handle17h006f831228e4b58bE"(ptr noalias noundef nonnull align 8 dereferenceable(24) %0, i64 noundef %8, i64 noundef %6)
+  %.pre = load i64, ptr %7, align 8
   br label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h9143d68ca1389f62E.llvm.10518328448262610784.exit"
 
-"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h9143d68ca1389f62E.llvm.10518328448262610784.exit": ; preds = %3, %13
-  %14 = phi i64 [ %9, %3 ], [ %.pre, %13 ]
+"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h9143d68ca1389f62E.llvm.10518328448262610784.exit": ; preds = %3, %12
+  %14 = phi i64 [ %8, %3 ], [ %.pre, %12 ]
   %15 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %16 = load ptr, ptr %15, align 8, !nonnull !7, !noundef !7
   %17 = getelementptr inbounds i8, ptr %16, i64 %14
-  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %17, ptr nonnull align 1 %1, i64 %7, i1 false)
-  %18 = load i64, ptr %8, align 8, !noundef !7
-  %19 = add i64 %18, %7
-  store i64 %19, ptr %8, align 8
+  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %17, ptr nonnull align 1 %1, i64 %6, i1 false)
+  %18 = load i64, ptr %7, align 8, !noundef !7
+  %19 = add i64 %18, %6
+  store i64 %19, ptr %7, align 8
   ret void
 }
 
diff --git a/bench/rayon-rs/optimized/4k8zt5cv4x2jivhi.ll b/bench/rayon-rs/optimized/4k8zt5cv4x2jivhi.ll
index 758901c018b..739777aefec 100644
--- a/bench/rayon-rs/optimized/4k8zt5cv4x2jivhi.ll
+++ b/bench/rayon-rs/optimized/4k8zt5cv4x2jivhi.ll
@@ -61,10 +61,11 @@ define hidden void @_ZN15crossbeam_epoch8deferred8Deferred3new4call17h2c83d87f31
   %3 = load i64, ptr %0, align 8, !noundef !4
   %4 = and i64 %3, -8
   %5 = inttoptr i64 %4 to ptr
-  %6 = load ptr, ptr %5, align 8, !nonnull !4, !noundef !4
+  %6 = load ptr, ptr %5, align 8, !noundef !4
   %7 = getelementptr inbounds nuw i8, ptr %5, i64 8
   %8 = load i64, ptr %7, align 8, !noundef !4
   call void @llvm.lifetime.start.p0(ptr nonnull %2)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
   store ptr %6, ptr %2, align 8
   %9 = getelementptr inbounds nuw i8, ptr %2, i64 8
   store i64 %8, ptr %9, align 8
@@ -74,11 +75,13 @@ define hidden void @_ZN15crossbeam_epoch8deferred8Deferred3new4call17h2c83d87f31
 10:                                               ; preds = %1
   %11 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %5) ]
   call void @__rust_dealloc(ptr noundef nonnull %5, i64 noundef 16, i64 noundef 8) #19
   resume { ptr, i32 } %11
 
 "_ZN15crossbeam_epoch5guard5Guard15defer_unchecked28_$u7b$$u7b$closure$u7d$$u7d$17h389c90f79e7d37dcE.exit": ; preds = %1
   call void @llvm.lifetime.end.p0(ptr nonnull %2)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %5) ]
   call void @__rust_dealloc(ptr noundef nonnull %5, i64 noundef 16, i64 noundef 8) #19
   ret void
 }
@@ -90,10 +93,11 @@ define hidden void @_ZN15crossbeam_epoch8deferred8Deferred3new4call17h94c2fe8421
   %4 = load i64, ptr %3, align 8, !noundef !4
   %5 = and i64 %4, -8
   %6 = inttoptr i64 %5 to ptr
-  %7 = load ptr, ptr %6, align 8, !nonnull !4, !noundef !4
+  %7 = load ptr, ptr %6, align 8, !noundef !4
   %8 = getelementptr inbounds nuw i8, ptr %6, i64 8
   %9 = load i64, ptr %8, align 8, !noundef !4
   call void @llvm.lifetime.start.p0(ptr nonnull %2)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %7) ]
   store ptr %7, ptr %2, align 8
   %10 = getelementptr inbounds nuw i8, ptr %2, i64 8
   store i64 %9, ptr %10, align 8
@@ -103,13 +107,17 @@ define hidden void @_ZN15crossbeam_epoch8deferred8Deferred3new4call17h94c2fe8421
 11:                                               ; preds = %1
   %12 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
   call void @__rust_dealloc(ptr noundef nonnull %6, i64 noundef 16, i64 noundef 8) #19
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3) ]
   call void @__rust_dealloc(ptr noundef nonnull %3, i64 noundef 8, i64 noundef 8) #19
   resume { ptr, i32 } %12
 
 13:                                               ; preds = %1
   call void @llvm.lifetime.end.p0(ptr nonnull %2)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
   call void @__rust_dealloc(ptr noundef nonnull %6, i64 noundef 16, i64 noundef 8) #19
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3) ]
   call void @__rust_dealloc(ptr noundef nonnull %3, i64 noundef 8, i64 noundef 8) #19
   ret void
 }
@@ -803,6 +811,7 @@ _ZN10rayon_core8registry12WorkerThread10wait_until17hfd0b4b8b47e514f2E.exit: ; p
 9:                                                ; preds = %8
   %10 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3) ]
   %11 = load ptr, ptr %3, align 8, !invariant.load !4, !nonnull !4
   invoke void %11(ptr noundef nonnull align 1 %2)
           to label %21 unwind label %12
@@ -810,6 +819,8 @@ _ZN10rayon_core8registry12WorkerThread10wait_until17hfd0b4b8b47e514f2E.exit: ; p
 12:                                               ; preds = %9
   %13 = landingpad { ptr, i32 }
           filter [0 x ptr] zeroinitializer
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3) ]
   %14 = getelementptr inbounds nuw i8, ptr %3, i64 8
   %15 = load i64, ptr %14, align 8, !range !19, !invariant.load !4
   %16 = getelementptr inbounds nuw i8, ptr %3, i64 16
@@ -824,6 +835,8 @@ _ZN10rayon_core8registry12WorkerThread10wait_until17hfd0b4b8b47e514f2E.exit: ; p
   br label %.body
 
 21:                                               ; preds = %9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3) ]
   %22 = getelementptr inbounds nuw i8, ptr %3, i64 8
   %23 = load i64, ptr %22, align 8, !range !19, !invariant.load !4
   %24 = getelementptr inbounds nuw i8, ptr %3, i64 16
@@ -1180,6 +1193,7 @@ define hidden void @_ZN10rayon_core5latch10CountLatch3new17hd2fc7d765e79c2b4E(pt
 4:                                                ; preds = %2
   %5 = getelementptr inbounds nuw i8, ptr %1, i64 272
   %.val.i = load ptr, ptr %5, align 16, !noalias !69, !nonnull !4, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   %6 = atomicrmw add ptr %.val.i, i64 1 monotonic, align 8, !noalias !69
   %7 = icmp slt i64 %6, 0
   br i1 %7, label %8, label %"_ZN68_$LT$alloc..sync..Arc$LT$T$C$A$GT$$u20$as$u20$core..clone..Clone$GT$5clone17hc6f63d21865d5022E.exit.i"
@@ -1214,6 +1228,7 @@ define void @_ZN10rayon_core5latch10CountLatch10with_count17h7b8f7be430f1b6bbE(p
 5:                                                ; preds = %3
   %6 = getelementptr inbounds nuw i8, ptr %2, i64 272
   %.val = load ptr, ptr %6, align 16, !nonnull !4, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %7 = atomicrmw add ptr %.val, i64 1 monotonic, align 8
   %8 = icmp slt i64 %7, 0
   br i1 %8, label %9, label %"_ZN68_$LT$alloc..sync..Arc$LT$T$C$A$GT$$u20$as$u20$core..clone..Clone$GT$5clone17hc6f63d21865d5022E.exit"
diff --git a/bench/re2/optimized/regexp.ll b/bench/re2/optimized/regexp.ll
index 078ab1f6e9b..1fff577d3a2 100644
--- a/bench/re2/optimized/regexp.ll
+++ b/bench/re2/optimized/regexp.ll
@@ -583,16 +583,13 @@ _ZN4absl7debian218container_internal12raw_hash_mapINS1_17FlatHashMapPolicyIPN3re
   %15 = phi ptr [ %.pre20.i, %if.then.i ], [ %6, %for.body.i.i ]
   %16 = phi ptr [ %.pre.i, %if.then.i ], [ %2, %for.body.i.i ]
   %retval.sroa.0.0.i15.i = phi i64 [ %call33.i.i, %if.then.i ], [ %and.i.i.i, %for.body.i.i ]
-  %cmp.not.i.i = icmp eq ptr %16, null
-  br i1 %cmp.not.i.i, label %cond.false.i.i, label %land.lhs.true.i.i
-
-land.lhs.true.i.i:                                ; preds = %_ZN4absl7debian218container_internal12raw_hash_mapINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE16try_emplace_implIS6_JEEESC_INS1_12raw_hash_setIS7_SA_SB_SF_E8iteratorEbEOT_DpOT0_.exit
   %add.ptr.i4.i = getelementptr inbounds i8, ptr %16, i64 %retval.sroa.0.0.i15.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %add.ptr.i4.i) ]
   %17 = load i8, ptr %add.ptr.i4.i, align 1
   %cmp.i.i.i = icmp sgt i8 %17, -1
   br i1 %cmp.i.i.i, label %_ZNK4absl7debian218container_internal12raw_hash_setINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE8iteratordeEv.exit, label %cond.false.i.i
 
-cond.false.i.i:                                   ; preds = %land.lhs.true.i.i, %_ZN4absl7debian218container_internal12raw_hash_mapINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE16try_emplace_implIS6_JEEESC_INS1_12raw_hash_setIS7_SA_SB_SF_E8iteratorEbEOT_DpOT0_.exit
+cond.false.i.i:                                   ; preds = %_ZN4absl7debian218container_internal12raw_hash_mapINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE16try_emplace_implIS6_JEEESC_INS1_12raw_hash_setIS7_SA_SB_SF_E8iteratorEbEOT_DpOT0_.exit
   tail call void @llvm.trap()
   unreachable
 
@@ -859,10 +856,7 @@ if.end29.i.i:                                     ; preds = %for.end.i.i
 
 _ZN4absl7debian218container_internal12raw_hash_setINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE4findIS6_EENSG_8iteratorERKT_.exit: ; preds = %for.body.i.i
   %add.ptr.i.i.i = getelementptr inbounds i8, ptr %2, i64 %and.i.i.i
-  %cmp.i.i = icmp eq ptr %2, null
-  br i1 %cmp.i.i, label %return, label %lor.lhs.false.i.i
-
-lor.lhs.false.i.i:                                ; preds = %_ZN4absl7debian218container_internal12raw_hash_setINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE4findIS6_EENSG_8iteratorERKT_.exit
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %add.ptr.i.i.i) ]
   %13 = load i8, ptr %add.ptr.i.i.i, align 1
   %cmp.i.i.i = icmp sgt i8 %13, -1
   br i1 %cmp.i.i.i, label %_ZN4absl7debian218container_internal12AssertIsFullEPa.exit.i, label %cond.false.i.i
@@ -921,8 +915,8 @@ _ZN4absl7debian218container_internal12raw_hash_setINS1_17FlatHashMapPolicyIPN3re
   store i64 %add16.i.i, ptr %settings_.i.i.i, align 8
   br label %return
 
-return:                                           ; preds = %for.end.i.i, %_ZN4absl7debian218container_internal12raw_hash_setINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE4findIS6_EENSG_8iteratorERKT_.exit, %_ZN4absl7debian218container_internal12raw_hash_setINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE5eraseENSG_8iteratorE.exit
-  %retval.0 = phi i64 [ 1, %_ZN4absl7debian218container_internal12raw_hash_setINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE5eraseENSG_8iteratorE.exit ], [ 0, %_ZN4absl7debian218container_internal12raw_hash_setINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE4findIS6_EENSG_8iteratorERKT_.exit ], [ 0, %for.end.i.i ]
+return:                                           ; preds = %for.end.i.i, %_ZN4absl7debian218container_internal12raw_hash_setINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE5eraseENSG_8iteratorE.exit
+  %retval.0 = phi i64 [ 1, %_ZN4absl7debian218container_internal12raw_hash_setINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE5eraseENSG_8iteratorE.exit ], [ 0, %for.end.i.i ]
   ret i64 %retval.0
 }
 
@@ -1122,16 +1116,13 @@ _ZN4absl7debian218container_internal12raw_hash_mapINS1_17FlatHashMapPolicyIPN3re
   %24 = phi ptr [ %.pre20.i.i, %call33.i.i.i.noexc ], [ %16, %for.body.i.i.i ]
   %25 = phi ptr [ %.pre.i.i, %call33.i.i.i.noexc ], [ %12, %for.body.i.i.i ]
   %retval.sroa.0.0.i15.i.i = phi i64 [ %call33.i.i.i46, %call33.i.i.i.noexc ], [ %and.i.i.i.i, %for.body.i.i.i ]
-  %cmp.not.i.i.i = icmp eq ptr %25, null
-  br i1 %cmp.not.i.i.i, label %cond.false.i.i.i, label %land.lhs.true.i.i.i
-
-land.lhs.true.i.i.i:                              ; preds = %_ZN4absl7debian218container_internal12raw_hash_mapINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE16try_emplace_implIS6_JEEESC_INS1_12raw_hash_setIS7_SA_SB_SF_E8iteratorEbEOT_DpOT0_.exit.i
   %add.ptr.i4.i.i = getelementptr inbounds i8, ptr %25, i64 %retval.sroa.0.0.i15.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %add.ptr.i4.i.i) ]
   %26 = load i8, ptr %add.ptr.i4.i.i, align 1
   %cmp.i.i.i.i = icmp sgt i8 %26, -1
   br i1 %cmp.i.i.i.i, label %invoke.cont3.i, label %cond.false.i.i.i
 
-cond.false.i.i.i:                                 ; preds = %land.lhs.true.i.i.i, %_ZN4absl7debian218container_internal12raw_hash_mapINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE16try_emplace_implIS6_JEEESC_INS1_12raw_hash_setIS7_SA_SB_SF_E8iteratorEbEOT_DpOT0_.exit.i
+cond.false.i.i.i:                                 ; preds = %_ZN4absl7debian218container_internal12raw_hash_mapINS1_17FlatHashMapPolicyIPN3re26RegexpEiEENS1_6HashEqIS6_vE4HashENS9_2EqESaISt4pairIKS6_iEEE16try_emplace_implIS6_JEEESC_INS1_12raw_hash_setIS7_SA_SB_SF_E8iteratorEbEOT_DpOT0_.exit.i
   call void @llvm.trap()
   unreachable
 
diff --git a/bench/regex-rs/optimized/3q3ceyp25m3d5uar.ll b/bench/regex-rs/optimized/3q3ceyp25m3d5uar.ll
index f90b006805d..f3dc5902fa8 100644
--- a/bench/regex-rs/optimized/3q3ceyp25m3d5uar.ll
+++ b/bench/regex-rs/optimized/3q3ceyp25m3d5uar.ll
@@ -56,6 +56,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !11
   call void @_ZN4core3fmt9Formatter10debug_list17h1616b9a56f5bf339E(ptr noalias noundef nonnull sret({ { ptr, i8, i8, [6 x i8] } }) align 8 captures(none) dereferenceable(16) %4, ptr noalias noundef nonnull align 8 dereferenceable(64) %1), !noalias !15
   %8 = getelementptr inbounds i8, ptr %5, i64 %7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   %9 = icmp eq i64 %7, 0
   br i1 %9, label %"_ZN48_$LT$$u5b$T$u5d$$u20$as$u20$core..fmt..Debug$GT$3fmt17h4613671e274b1b60E.exit", label %.lr.ph.i.i
 
@@ -380,6 +381,7 @@ define void @"_ZN80_$LT$alloc..borrow..Cow$LT$str$GT$$u20$as$u20$regex..regex..s
   %4 = getelementptr inbounds nuw i8, ptr %1, i64 16
   %.val1 = load i64, ptr %4, align 8, !alias.scope !95, !noundef !4
   tail call void @llvm.experimental.noalias.scope.decl(metadata !100)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = getelementptr inbounds i8, ptr %.val, i64 %.val1
   %6 = tail call noundef ptr @_ZN4core4sync6atomic11atomic_load17h705600093d4b62c0E.llvm.15639794734364571569(ptr noundef nonnull @_ZN6memchr4arch6x86_646memchr10memchr_raw2FN17h16b0072529d6b791E, i8 noundef 0), !noalias !103
   %7 = tail call { i64, ptr } %6(i8 noundef 36, ptr noundef nonnull readonly align 1 %.val, ptr noundef nonnull readonly %5), !noalias !110
@@ -420,6 +422,7 @@ define void @"_ZN84_$LT$$RF$alloc..borrow..Cow$LT$str$GT$$u20$as$u20$regex..rege
 define void @"_ZN84_$LT$$RF$alloc..borrow..Cow$LT$str$GT$$u20$as$u20$regex..regex..string..Replacer$GT$12no_expansion17hec643b6db3fd41ccE"(ptr noalias noundef writeonly sret({ i64, [2 x i64] }) align 8 captures(none) dereferenceable(24) initializes((0, 8)) %0, ptr noalias noundef readonly align 8 captures(none) dereferenceable(8) %1) unnamed_addr #0 personality ptr @rust_eh_personality {
   %.val = load ptr, ptr %1, align 8, !nonnull !4, !align !19, !noundef !4
   tail call void @llvm.experimental.noalias.scope.decl(metadata !121)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %.pn1.in.i.i.i.i = getelementptr inbounds nuw i8, ptr %.val, i64 16
   %.pn1.i.i.i.i = load i64, ptr %.pn1.in.i.i.i.i, align 8, !alias.scope !124, !noalias !121, !noundef !4
   %.pn3.in.i.i.i.i = getelementptr inbounds nuw i8, ptr %.val, i64 8
@@ -546,7 +549,7 @@ define void @_ZN5regex8regexset6string8RegexSet5empty17h8a63d6d8e63de650E(ptr no
 9:                                                ; preds = %7
   %10 = landingpad { ptr, i32 }
           filter [0 x ptr] zeroinitializer
-  call void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() #13, !noalias !173
+  call void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() #14, !noalias !173
   unreachable
 
 common.resume:                                    ; preds = %.body, %7
@@ -595,7 +598,7 @@ _ZN5regex8builders6string15RegexSetBuilder5build17hffb6420d29d8fa68E.exit: ; pre
 20:                                               ; preds = %17
   %21 = landingpad { ptr, i32 }
           filter [0 x ptr] zeroinitializer
-  call void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() #13, !noalias !181
+  call void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() #14, !noalias !181
   unreachable
 
 22:                                               ; preds = %_ZN5regex8builders6string15RegexSetBuilder5build17hffb6420d29d8fa68E.exit
@@ -874,6 +877,9 @@ declare noundef zeroext i1 @_ZN4core3fmt9Formatter9write_fmt17heacf5dba8c40948fE
 ; Function Attrs: nonlazybind uwtable
 declare void @"_ZN67_$LT$regex..builders..Builder$u20$as$u20$core..default..Default$GT$7default17hea6e786948e237ffE"(ptr noalias noundef sret({ { { i64, i64 }, { i64, i64 }, { i64, i64 }, { i64, i64 }, { i64, i64 }, { [16 x i8], i8, [7 x i8] }, { i8, i8 }, i8, i8, i8, i8, i8, i8, i8, i8, i8, [5 x i8] }, { { i64, ptr }, i64 }, { i32, i8, i8, i8, i8, i8, i8, i8, i8, i8, i8, [2 x i8] } }) align 8 captures(none) dereferenceable(160)) unnamed_addr #0
 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #8
+
 ; Function Attrs: nonlazybind uwtable
 declare hidden void @_ZN5regex8builders7Builder17build_many_string17hec7233caad9e5720E(ptr noalias noundef sret({ ptr, [3 x i64] }) align 8 captures(none) dereferenceable(32), ptr noalias noundef readonly align 8 dereferenceable(160)) unnamed_addr #0
 
@@ -924,13 +930,14 @@ attributes #4 = { mustprogress nofree norecurse nosync nounwind nonlazybind will
 attributes #5 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
 attributes #6 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #7 = { cold noreturn nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #8 = { inlinehint nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #9 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
+attributes #8 = { mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #9 = { inlinehint nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #10 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
-attributes #11 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
-attributes #12 = { cold }
-attributes #13 = { cold noreturn nounwind }
-attributes #14 = { noreturn }
+attributes #11 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #12 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
+attributes #13 = { cold }
+attributes #14 = { cold noreturn nounwind }
+attributes #15 = { noreturn }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/regex-rs/optimized/4p7mqoqm6h8kkgbs.ll b/bench/regex-rs/optimized/4p7mqoqm6h8kkgbs.ll
index 307e56b1a19..f4baa006b36 100644
--- a/bench/regex-rs/optimized/4p7mqoqm6h8kkgbs.ll
+++ b/bench/regex-rs/optimized/4p7mqoqm6h8kkgbs.ll
@@ -87,32 +87,30 @@ define hidden { i32, ptr } @"_ZN119_$LT$regex_automata..util..primitives..WithPa
 
 ; Function Attrs: nonlazybind uwtable
 define hidden void @"_ZN14regex_automata4util10primitives26WithPatternIDIter$LT$I$GT$3new17h164bef4487389f03E"(ptr noalias noundef writeonly sret({ { ptr, ptr }, { i64, i64 } }) align 8 captures(none) dereferenceable(32) initializes((0, 32)) %0, ptr noundef nonnull %1, ptr noundef %2) unnamed_addr #1 personality ptr @rust_eh_personality {
-  %4 = icmp ne ptr %2, null
-  tail call void @llvm.assume(i1 %4)
-  %5 = ptrtoint ptr %2 to i64
-  %6 = ptrtoint ptr %1 to i64
-  %7 = sub nuw i64 %5, %6
-  %8 = udiv exact i64 %7, 24
-  %9 = tail call { i64, i64 } @_ZN14regex_automata4util10primitives9PatternID4iter17h1c20efa7ef38c895E(i64 noundef %8)
-  %10 = extractvalue { i64, i64 } %9, 0
-  %11 = extractvalue { i64, i64 } %9, 1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  %4 = ptrtoint ptr %2 to i64
+  %5 = ptrtoint ptr %1 to i64
+  %6 = sub nuw i64 %4, %5
+  %7 = udiv exact i64 %6, 24
+  %8 = tail call { i64, i64 } @_ZN14regex_automata4util10primitives9PatternID4iter17h1c20efa7ef38c895E(i64 noundef %7)
+  %9 = extractvalue { i64, i64 } %8, 0
+  %10 = extractvalue { i64, i64 } %9, 1
   store ptr %1, ptr %0, align 8
   %12 = getelementptr inbounds nuw i8, ptr %0, i64 8
   store ptr %2, ptr %12, align 8
   %13 = getelementptr inbounds nuw i8, ptr %0, i64 16
+  store i64 %9, ptr %12, align 8
+  %13 = getelementptr inbounds nuw i8, ptr %0, i64 24
   store i64 %10, ptr %13, align 8
-  %14 = getelementptr inbounds nuw i8, ptr %0, i64 24
-  store i64 %11, ptr %14, align 8
   ret void
 }
 
 ; Function Attrs: nonlazybind uwtable
 define hidden noundef nonnull align 8 dereferenceable(16) ptr @_ZN4core3fmt8builders9DebugList7entries17h638ebb64988d77fbE(ptr noalias noundef returned align 8 dereferenceable(16) %0, ptr noundef nonnull %1, ptr noundef readnone captures(address) %2) unnamed_addr #1 personality ptr @rust_eh_personality {
   %4 = alloca ptr, align 8
-  %5 = icmp ne ptr %2, null
-  tail call void @llvm.assume(i1 %5)
-  %6 = icmp eq ptr %1, %2
-  br i1 %6, label %._crit_edge, label %.lr.ph
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  %5 = icmp eq ptr %1, %2
+  br i1 %5, label %._crit_edge, label %.lr.ph
 
 ._crit_edge:                                      ; preds = %.lr.ph, %3
   ret ptr %0
@@ -131,10 +129,9 @@ define hidden noundef nonnull align 8 dereferenceable(16) ptr @_ZN4core3fmt8buil
 ; Function Attrs: nonlazybind uwtable
 define hidden noundef nonnull align 8 dereferenceable(16) ptr @_ZN4core3fmt8builders9DebugList7entries17hb2f13a246b67dd1fE(ptr noalias noundef returned align 8 dereferenceable(16) %0, ptr noundef nonnull %1, ptr noundef readnone captures(address) %2) unnamed_addr #1 personality ptr @rust_eh_personality {
   %4 = alloca ptr, align 8
-  %5 = icmp ne ptr %2, null
-  tail call void @llvm.assume(i1 %5)
-  %6 = icmp eq ptr %1, %2
-  br i1 %6, label %._crit_edge, label %.lr.ph
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  %5 = icmp eq ptr %1, %2
+  br i1 %5, label %._crit_edge, label %.lr.ph
 
 ._crit_edge:                                      ; preds = %.lr.ph, %3
   ret ptr %0
diff --git a/bench/regex-rs/optimized/gbxkn0az9l87aop.ll b/bench/regex-rs/optimized/gbxkn0az9l87aop.ll
index 9bc6c8f86bf..340430026ae 100644
--- a/bench/regex-rs/optimized/gbxkn0az9l87aop.ll
+++ b/bench/regex-rs/optimized/gbxkn0az9l87aop.ll
@@ -495,6 +495,7 @@ _ZN4core5slice4sort20provide_sorted_batch17h0d7e2195e03eaf6dE.exit: ; preds = %.
   br label %.invoke217
 
 173:                                              ; preds = %170
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre154) ]
   %174 = getelementptr inbounds { i64, i64 }, ptr %.pre154, i64 %.sroa.4.0.i52.ph
   %175 = load i64, ptr %174, align 8, !noundef !14
   %176 = getelementptr inbounds nuw i8, ptr %174, i64 8
@@ -526,6 +527,7 @@ _ZN4core5slice4sort20provide_sorted_batch17h0d7e2195e03eaf6dE.exit: ; preds = %.
   unreachable
 
 182:                                              ; preds = %173
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre154) ]
   %183 = getelementptr inbounds { i64, i64 }, ptr %.pre154, i64 %178
   %184 = load i64, ptr %183, align 8, !noundef !14
   %185 = getelementptr inbounds nuw i8, ptr %183, i64 8
@@ -618,6 +620,7 @@ _ZN4core5slice4sort20provide_sorted_batch17h0d7e2195e03eaf6dE.exit: ; preds = %.
   %.02818.i = phi ptr [ %231, %.lr.ph.i63 ], [ %199, %207 ]
   %.sroa.0.117.i = phi ptr [ %234, %.lr.ph.i63 ], [ %14, %207 ]
   %.sroa.18.216.i = phi ptr [ %229, %.lr.ph.i63 ], [ %198, %207 ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.117.i) ]
   %.028.val.i = load i64, ptr %.02818.i, align 8, !alias.scope !100, !noalias !101, !noundef !14
   %224 = getelementptr i8, ptr %.02818.i, i64 24
   %.028.val35.i = load i64, ptr %224, align 8, !alias.scope !86
@@ -648,7 +651,8 @@ _ZN4core5slice4sort20provide_sorted_batch17h0d7e2195e03eaf6dE.exit: ; preds = %.
   %237 = ptrtoint ptr %.sroa.10.1.i to i64
   %238 = ptrtoint ptr %.sroa.0.0.i62 to i64
   %239 = sub nuw i64 %237, %238
-  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 8 %.sroa.18.1.i, ptr align 8 %.sroa.0.0.i62, i64 %239, i1 false), !noalias !102
+  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 8 %.sroa.18.1.i, ptr nonnull align 8 %.sroa.0.0.i62, i64 %239, i1 false), !noalias !102
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre154) ]
   %240 = add i64 %184, %175
   store i64 %240, ptr %183, align 8
   store i64 %177, ptr %185, align 8
@@ -1214,6 +1218,7 @@ _ZN4core5slice4sort20provide_sorted_batch17hfd7792d2e61b7fbbE.exit: ; preds = %.
   br label %.invoke221
 
 175:                                              ; preds = %172
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre155) ]
   %176 = getelementptr inbounds { i64, i64 }, ptr %.pre155, i64 %.sroa.4.0.i52.ph
   %177 = load i64, ptr %176, align 8, !noundef !14
   %178 = getelementptr inbounds nuw i8, ptr %176, i64 8
@@ -1245,6 +1250,7 @@ _ZN4core5slice4sort20provide_sorted_batch17hfd7792d2e61b7fbbE.exit: ; preds = %.
   unreachable
 
 184:                                              ; preds = %175
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre155) ]
   %185 = getelementptr inbounds { i64, i64 }, ptr %.pre155, i64 %180
   %186 = load i64, ptr %185, align 8, !noundef !14
   %187 = getelementptr inbounds nuw i8, ptr %185, i64 8
@@ -1349,6 +1355,7 @@ _ZN4core3ops8function5FnMut8call_mut17hc471639bb37c37ffE.exit.thread.i: ; preds
   %.02829.i = phi ptr [ %239, %_ZN4core3ops8function5FnMut8call_mut17hc471639bb37c37ffE.exit43.thread.i ], [ %201, %209 ]
   %.sroa.0.128.i = phi ptr [ %242, %_ZN4core3ops8function5FnMut8call_mut17hc471639bb37c37ffE.exit43.thread.i ], [ %13, %209 ]
   %.sroa.18.227.i = phi ptr [ %237, %_ZN4core3ops8function5FnMut8call_mut17hc471639bb37c37ffE.exit43.thread.i ], [ %200, %209 ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.128.i) ]
   %.028.val.i = load i8, ptr %.02829.i, align 1, !alias.scope !183, !noundef !14
   %.val.i65 = load i8, ptr %.sroa.0.128.i, align 1, !noalias !183, !noundef !14
   %230 = icmp ult i8 %.028.val.i, %.val.i65
@@ -1390,7 +1397,8 @@ _ZN4core3ops8function5FnMut8call_mut17hc471639bb37c37ffE.exit43.thread.i: ; pred
   %245 = ptrtoint ptr %.sroa.10.1.i to i64
   %246 = ptrtoint ptr %.sroa.0.0.i63 to i64
   %247 = sub nuw i64 %245, %246
-  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %.sroa.18.1.i, ptr align 1 %.sroa.0.0.i63, i64 %247, i1 false), !noalias !186
+  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %.sroa.18.1.i, ptr nonnull align 1 %.sroa.0.0.i63, i64 %247, i1 false), !noalias !186
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre155) ]
   %248 = add i64 %186, %177
   store i64 %248, ptr %185, align 8
   store i64 %179, ptr %187, align 8
@@ -1960,6 +1968,7 @@ _ZN4core5slice4sort20provide_sorted_batch17h43f6f797a37a05edE.exit: ; preds = %.
   br label %.invoke221
 
 175:                                              ; preds = %172
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre155) ]
   %176 = getelementptr inbounds { i64, i64 }, ptr %.pre155, i64 %.sroa.4.0.i52.ph
   %177 = load i64, ptr %176, align 8, !noundef !14
   %178 = getelementptr inbounds nuw i8, ptr %176, i64 8
@@ -1991,6 +2000,7 @@ _ZN4core5slice4sort20provide_sorted_batch17h43f6f797a37a05edE.exit: ; preds = %.
   unreachable
 
 184:                                              ; preds = %175
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre155) ]
   %185 = getelementptr inbounds { i64, i64 }, ptr %.pre155, i64 %180
   %186 = load i64, ptr %185, align 8, !noundef !14
   %187 = getelementptr inbounds nuw i8, ptr %185, i64 8
@@ -2095,6 +2105,7 @@ _ZN4core3ops8function5FnMut8call_mut17h903e79e8964f77fcE.exit.thread.i: ; preds
   %.02829.i = phi ptr [ %239, %_ZN4core3ops8function5FnMut8call_mut17h903e79e8964f77fcE.exit43.thread.i ], [ %201, %209 ]
   %.sroa.0.128.i = phi ptr [ %242, %_ZN4core3ops8function5FnMut8call_mut17h903e79e8964f77fcE.exit43.thread.i ], [ %14, %209 ]
   %.sroa.18.227.i = phi ptr [ %237, %_ZN4core3ops8function5FnMut8call_mut17h903e79e8964f77fcE.exit43.thread.i ], [ %200, %209 ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.128.i) ]
   %.028.val.i = load i32, ptr %.02829.i, align 4, !range !216, !alias.scope !255, !noundef !14
   %.val.i65 = load i32, ptr %.sroa.0.128.i, align 4, !range !216, !noalias !255, !noundef !14
   %230 = icmp samesign ult i32 %.028.val.i, %.val.i65
@@ -2136,7 +2147,8 @@ _ZN4core3ops8function5FnMut8call_mut17h903e79e8964f77fcE.exit43.thread.i: ; pred
   %245 = ptrtoint ptr %.sroa.10.1.i to i64
   %246 = ptrtoint ptr %.sroa.0.0.i63 to i64
   %247 = sub nuw i64 %245, %246
-  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 4 %.sroa.18.1.i, ptr align 4 %.sroa.0.0.i63, i64 %247, i1 false), !noalias !258
+  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 4 %.sroa.18.1.i, ptr nonnull align 4 %.sroa.0.0.i63, i64 %247, i1 false), !noalias !258
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.pre155) ]
   %248 = add i64 %186, %177
   store i64 %248, ptr %185, align 8
   store i64 %179, ptr %187, align 8
diff --git a/bench/ring-rs/optimized/1ifa1mnaz8f3h6jb.ll b/bench/ring-rs/optimized/1ifa1mnaz8f3h6jb.ll
index 7697d3166cf..654be86b186 100644
--- a/bench/ring-rs/optimized/1ifa1mnaz8f3h6jb.ll
+++ b/bench/ring-rs/optimized/1ifa1mnaz8f3h6jb.ll
@@ -1190,6 +1190,8 @@ default.unreachable:                              ; preds = %_ZN4ring4aead5block
 _ZN4ring4aead3aes3Key13encrypt_block17hb516baeef254fb70E.exit: ; preds = %86, %87, %88
   call void @llvm.lifetime.start.p0(ptr nonnull %21)
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 16 dereferenceable(16) %21, ptr noundef nonnull align 1 dereferenceable(16) %.sroa.087, i64 16, i1 false)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %21) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.i) ]
   br label %89
 
 89:                                               ; preds = %89, %_ZN4ring4aead3aes3Key13encrypt_block17hb516baeef254fb70E.exit
@@ -1197,6 +1199,7 @@ _ZN4ring4aead3aes3Key13encrypt_block17hb516baeef254fb70E.exit: ; preds = %86, %8
   %90 = add nuw nsw i64 %.sroa.8.013.i, 1
   %91 = getelementptr inbounds nuw i8, ptr %21, i64 %.sroa.8.013.i
   %92 = getelementptr inbounds nuw i8, ptr %.sroa.0.i, i64 %.sroa.8.013.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %92) ]
   %93 = load i8, ptr %92, align 1, !noundef !4
   %94 = load i8, ptr %91, align 1, !alias.scope !156, !noalias !159, !noundef !4
   %95 = xor i8 %94, %93
@@ -2400,27 +2403,34 @@ _ZN4ring6digest7Context6finish17ha820283835585a81E.exit: ; preds = %.split11
   unreachable
 
 "_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17heb3913cfe867f2eeE.exit": ; preds = %_ZN4ring6digest7Context6finish17ha820283835585a81E.exit
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %26) ]
   %.0.sroa.speculated.i.i.i13 = call noundef i64 @llvm.umin.i64(i64 %.0.sroa.speculated.i.i.i, i64 %39)
   %.not = icmp eq i64 %39, 0
-  br i1 %.not, label %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit.thread", label %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit"
+  br i1 %.not, label %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit.thread", label %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit.lr.ph"
+
+"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit.lr.ph": ; preds = %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17heb3913cfe867f2eeE.exit"
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.045) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %20) ]
+  br label %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit"
+
+"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit": ; preds = %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit.lr.ph", %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit"
+  %.sroa.826.044 = phi i64 [ 0, %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit.lr.ph" ], [ %44, %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit" ]
+  %42 = getelementptr inbounds i8, ptr %.sroa.0.045, i64 %.sroa.826.044
+  %43 = getelementptr inbounds i8, ptr %20, i64 %.sroa.826.044
+  %44 = add nuw i64 %.sroa.826.044, 1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %43) ]
+  %45 = load i8, ptr %43, align 1, !noundef !4
+  %46 = load i8, ptr %42, align 1, !noundef !4
+  %47 = xor i8 %46, %45
+  store i8 %47, ptr %42, align 1
+  %exitcond.not = icmp eq i64 %44, %.0.sroa.speculated.i.i.i13
+  br i1 %exitcond.not, label %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit.thread", label %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit"
 
 "_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit.thread": ; preds = %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit", %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17heb3913cfe867f2eeE.exit"
   call void @llvm.lifetime.end.p0(ptr nonnull %10)
   call void @llvm.lifetime.end.p0(ptr nonnull %12)
   %42 = icmp eq i64 %27, 0
   br i1 %42, label %"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$10chunks_mut17hbb007d906e555d86E.exit._crit_edge", label %"_ZN96_$LT$core..slice..iter..ChunksMut$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17heddf377f49250887E.exit.i"
-
-"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit": ; preds = %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17heb3913cfe867f2eeE.exit", %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit"
-  %.sroa.826.044 = phi i64 [ %45, %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit" ], [ 0, %"_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$5index17heb3913cfe867f2eeE.exit" ]
-  %43 = getelementptr inbounds i8, ptr %.sroa.0.045, i64 %.sroa.826.044
-  %44 = getelementptr inbounds i8, ptr %20, i64 %.sroa.826.044
-  %45 = add nuw i64 %.sroa.826.044, 1
-  %46 = load i8, ptr %44, align 1, !noundef !4
-  %47 = load i8, ptr %43, align 1, !noundef !4
-  %48 = xor i8 %47, %46
-  store i8 %48, ptr %43, align 1
-  %exitcond.not = icmp eq i64 %45, %.0.sroa.speculated.i.i.i13
-  br i1 %exitcond.not, label %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit.thread", label %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h43496d6b3ada6ba2E.exit"
 }
 
 ; Function Attrs: nonlazybind uwtable
diff --git a/bench/ring-rs/optimized/d308x8t7de9vep4.ll b/bench/ring-rs/optimized/d308x8t7de9vep4.ll
index 13e1a8928a7..e9ddf1422b9 100644
--- a/bench/ring-rs/optimized/d308x8t7de9vep4.ll
+++ b/bench/ring-rs/optimized/d308x8t7de9vep4.ll
@@ -53,7 +53,7 @@ define internal void @_ZN4core3ops8function6FnOnce9call_once17h13bc0bb185bac1d6E
   br i1 %6, label %7, label %"_ZN4ring2ec7suite_b3ops4p38417PUBLIC_SCALAR_OPS28_$u7b$$u7b$closure$u7d$$u7d$17h11b51cb358a6c563E.exit"
 
 7:                                                ; preds = %2
-  tail call void @_ZN4core9panicking5panic17hb837a5ebbbe5b188E(ptr noalias noundef nonnull readonly align 1 @anon.a08cbc0fed5954eef0273385eb99bffc.58.llvm.8403485840513791397, i64 noundef 52, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.a08cbc0fed5954eef0273385eb99bffc.59.llvm.8403485840513791397) #10, !noalias !8
+  tail call void @_ZN4core9panicking5panic17hb837a5ebbbe5b188E(ptr noalias noundef nonnull readonly align 1 @anon.a08cbc0fed5954eef0273385eb99bffc.58.llvm.8403485840513791397, i64 noundef 52, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.a08cbc0fed5954eef0273385eb99bffc.59.llvm.8403485840513791397) #11, !noalias !8
   unreachable
 
 "_ZN4ring2ec7suite_b3ops4p38417PUBLIC_SCALAR_OPS28_$u7b$$u7b$closure$u7d$$u7d$17h11b51cb358a6c563E.exit": ; preds = %2
@@ -133,6 +133,7 @@ define hidden { i8, i8 } @"_ZN4core4iter8adapters8peekable17Peekable$LT$I$GT$7ne
 
 18:                                               ; preds = %16
   %.val = load ptr, ptr %1, align 8, !nonnull !67, !align !71, !noundef !67
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %.val2.i = load i8, ptr %.val, align 1, !noundef !67
   %19 = icmp eq i8 %.sroa.6.0, %.val2.i
   br i1 %19, label %22, label %20
@@ -195,6 +196,7 @@ define hidden { i8, i8 } @"_ZN4core4iter8adapters8peekable17Peekable$LT$I$GT$7ne
 
 18:                                               ; preds = %16
   %.val = load ptr, ptr %1, align 8, !nonnull !67, !align !71, !noundef !67
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %.val2.i = load i8, ptr %.val, align 1, !noundef !67
   %19 = icmp eq i8 %.sroa.6.0, %.val2.i
   br i1 %19, label %22, label %20
@@ -942,7 +944,7 @@ _ZN9untrusted6reader6Reader4peek17hd8bdc58f301fd15eE.exit.thread.i: ; preds = %_
 47:                                               ; preds = %44
   %48 = landingpad { ptr, i32 }
           filter [0 x ptr] zeroinitializer
-  call void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() #12, !noalias !137
+  call void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() #13, !noalias !137
   unreachable
 
 common.resume:                                    ; preds = %61, %44
@@ -1191,7 +1193,7 @@ _ZN9untrusted6reader6Reader4peek17hd8bdc58f301fd15eE.exit.thread.i: ; preds = %_
 47:                                               ; preds = %44
   %48 = landingpad { ptr, i32 }
           filter [0 x ptr] zeroinitializer
-  call void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() #12, !noalias !158
+  call void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() #13, !noalias !158
   unreachable
 
 common.resume:                                    ; preds = %61, %44
@@ -1440,7 +1442,7 @@ _ZN9untrusted6reader6Reader4peek17hd8bdc58f301fd15eE.exit.thread.i: ; preds = %_
 47:                                               ; preds = %44
   %48 = landingpad { ptr, i32 }
           filter [0 x ptr] zeroinitializer
-  call void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() #12, !noalias !178
+  call void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() #13, !noalias !178
   unreachable
 
 common.resume:                                    ; preds = %61, %44
@@ -1689,7 +1691,7 @@ _ZN9untrusted6reader6Reader4peek17hd8bdc58f301fd15eE.exit.thread.i: ; preds = %_
 47:                                               ; preds = %44
   %48 = landingpad { ptr, i32 }
           filter [0 x ptr] zeroinitializer
-  call void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() #12, !noalias !198
+  call void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() #13, !noalias !198
   unreachable
 
 common.resume:                                    ; preds = %61, %44
@@ -2024,7 +2026,7 @@ define hidden void @"_ZN4ring10arithmetic6bigint7modulus21OwnedModulus$LT$M$GT$8
   br i1 %10, label %11, label %_ZN4ring4limb19unstripped_be_bytes17h0b353aee86fe7c5cE.exit
 
 11:                                               ; preds = %2
-  tail call void @_ZN4core9panicking5panic17hb837a5ebbbe5b188E(ptr noalias noundef nonnull readonly align 1 @anon.459a524322d1240f21a5a0b37f1bf450.18.llvm.9292951165861561203, i64 noundef 43, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.459a524322d1240f21a5a0b37f1bf450.19.llvm.9292951165861561203) #10, !noalias !233
+  tail call void @_ZN4core9panicking5panic17hb837a5ebbbe5b188E(ptr noalias noundef nonnull readonly align 1 @anon.459a524322d1240f21a5a0b37f1bf450.18.llvm.9292951165861561203, i64 noundef 43, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.459a524322d1240f21a5a0b37f1bf450.19.llvm.9292951165861561203) #11, !noalias !233
   unreachable
 
 _ZN4ring4limb19unstripped_be_bytes17h0b353aee86fe7c5cE.exit: ; preds = %2
@@ -3072,6 +3074,9 @@ declare void @llvm.memcpy.p0.p0.i64(ptr noalias writeonly captures(none), ptr no
 ; Function Attrs: cold noreturn nounwind nonlazybind uwtable
 declare void @_ZN4core9panicking16panic_in_cleanup17h55eb1d85cadde1a1E() unnamed_addr #6
 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #7
+
 ; Function Attrs: nonlazybind uwtable
 declare hidden { ptr, i64 } @"_ZN5alloc3vec16Vec$LT$T$C$A$GT$16into_boxed_slice17h74bbbcbcd4e8da8dE"(ptr noalias noundef align 8 captures(none) dereferenceable(24)) unnamed_addr #1
 
@@ -3167,11 +3172,12 @@ attributes #4 = { nonlazybind "target-cpu"="x86-64" }
 attributes #5 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
 attributes #6 = { cold noreturn nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #7 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: write) }
-attributes #8 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
+attributes #8 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: write) }
 attributes #9 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
-attributes #10 = { noreturn }
-attributes #11 = { cold }
-attributes #12 = { cold noreturn nounwind }
+attributes #10 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #11 = { noreturn }
+attributes #12 = { cold }
+attributes #13 = { cold noreturn nounwind }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/ripgrep-rs/optimized/5ckxrdy9v0i8g3uf.ll b/bench/ripgrep-rs/optimized/5ckxrdy9v0i8g3uf.ll
index 52d4bc2e511..94bf396ff4c 100644
--- a/bench/ripgrep-rs/optimized/5ckxrdy9v0i8g3uf.ll
+++ b/bench/ripgrep-rs/optimized/5ckxrdy9v0i8g3uf.ll
@@ -170,9 +170,11 @@ define hidden { i64, i64 } @"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$16bina
   br i1 %.not, label %._crit_edge, label %.lr.ph
 
 .lr.ph:                                           ; preds = %4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3) ]
   %.val4.i = load ptr, ptr %3, align 8, !nonnull !5, !align !29, !noundef !5
   %5 = getelementptr inbounds nuw i8, ptr %3, i64 8
   %.val5.i = load i64, ptr %5, align 8, !noundef !5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val4.i) ]
   br label %7
 
 ._crit_edge:                                      ; preds = %20, %4
@@ -193,6 +195,8 @@ define hidden { i64, i64 } @"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$16bina
   %.val23 = load ptr, ptr %11, align 8, !nonnull !5, !align !29, !noundef !5
   %12 = getelementptr i8, ptr %11, i64 8
   %.val24 = load i64, ptr %12, align 8, !noundef !5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val23) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val23) ]
   %13 = sub i64 %.val24, %.val5.i
   %..i.i.i.i = tail call i64 @llvm.umin.i64(i64 %.val24, i64 %.val5.i)
   %14 = tail call i32 @memcmp(ptr nonnull readonly align 1 %.val23, ptr nonnull readonly align 1 %.val4.i, i64 %..i.i.i.i), !alias.scope !40
@@ -228,9 +232,11 @@ define hidden { i64, i64 } @"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$20bina
   br i1 %.not.i, label %._crit_edge.i, label %.lr.ph.i
 
 .lr.ph.i:                                         ; preds = %3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
   %.val4.i.i = load ptr, ptr %2, align 8, !alias.scope !50, !noalias !47, !nonnull !5, !align !29, !noundef !5
   %4 = getelementptr inbounds nuw i8, ptr %2, i64 8
   %.val5.i.i = load i64, ptr %4, align 8, !alias.scope !50, !noalias !47, !noundef !5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val4.i.i) ]
   br label %6
 
 ._crit_edge.i:                                    ; preds = %17, %3
@@ -251,6 +257,8 @@ define hidden { i64, i64 } @"_ZN4core5slice29_$LT$impl$u20$$u5b$T$u5d$$GT$20bina
   %.val23.i = load ptr, ptr %10, align 8, !alias.scope !47, !noalias !50, !nonnull !5, !align !29, !noundef !5
   %11 = getelementptr i8, ptr %10, i64 8
   %.val24.i = load i64, ptr %11, align 8, !alias.scope !47, !noalias !50, !noundef !5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val23.i) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val23.i) ]
   %12 = sub i64 %.val24.i, %.val5.i.i
   %..i.i.i.i.i = tail call i64 @llvm.umin.i64(i64 %.val24.i, i64 %.val5.i.i)
   %13 = tail call i32 @memcmp(ptr nonnull readonly align 1 %.val23.i, ptr nonnull readonly align 1 %.val4.i.i, i64 %..i.i.i.i.i), !alias.scope !52, !noalias !59
@@ -316,6 +324,7 @@ define hidden void @"_ZN4core6result19Result$LT$T$C$E$GT$3map17h6a87aff857aa28b1
 define hidden { ptr, i64 } @_ZN12grep_printer17hyperlink_aliases4find17h74de6dce8637fe14E(ptr noalias noundef nonnull readonly align 1 captures(none) %0, i64 noundef %1) unnamed_addr #5 personality ptr @rust_eh_personality {
   tail call void @llvm.experimental.noalias.scope.decl(metadata !61)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !64)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   br label %3
 
 3:                                                ; preds = %14, %2
@@ -330,6 +339,8 @@ define hidden { ptr, i64 } @_ZN12grep_printer17hyperlink_aliases4find17h74de6dce
   %.val23.i.i = load ptr, ptr %7, align 8, !alias.scope !67, !noalias !68, !nonnull !5, !align !29, !noundef !5
   %8 = getelementptr i8, ptr %7, i64 8
   %.val24.i.i = load i64, ptr %8, align 8, !alias.scope !67, !noalias !68, !noundef !5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val23.i.i) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val23.i.i) ]
   %9 = sub i64 %.val24.i.i, %1
   %..i.i.i.i.i.i = tail call i64 @llvm.umin.i64(i64 %.val24.i.i, i64 %1)
   %10 = tail call i32 @memcmp(ptr nonnull readonly align 1 %.val23.i.i, ptr nonnull readonly align 1 %0, i64 %..i.i.i.i.i.i), !alias.scope !71, !noalias !78
diff --git a/bench/rocksdb/optimized/arena_wrapped_db_iter.ll b/bench/rocksdb/optimized/arena_wrapped_db_iter.ll
index 62ac30a1d21..9140527220b 100644
--- a/bench/rocksdb/optimized/arena_wrapped_db_iter.ll
+++ b/bench/rocksdb/optimized/arena_wrapped_db_iter.ll
@@ -2258,23 +2258,22 @@ define linkonce_odr void @_ZN7rocksdb18ArenaWrappedDBIter18SetIterUnderDBIterEPN
   %4 = load ptr, ptr %3, align 8, !tbaa !17
   %5 = getelementptr inbounds nuw i8, ptr %4, i64 88
   store ptr %1, ptr %5, align 8, !tbaa !290
-  %6 = icmp ne ptr %1, null
-  tail call void @llvm.assume(i1 %6)
-  %7 = load ptr, ptr %1, align 8, !tbaa !95
-  %8 = getelementptr inbounds nuw i8, ptr %7, i64 24
-  %9 = load ptr, ptr %8, align 8
-  %10 = tail call noundef zeroext i1 %9(ptr noundef nonnull align 8 dereferenceable(40) %1)
-  %11 = getelementptr inbounds nuw i8, ptr %4, i64 120
-  %12 = zext i1 %10 to i8
-  store i8 %12, ptr %11, align 8, !tbaa !361
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
+  %6 = load ptr, ptr %1, align 8, !tbaa !95
+  %7 = getelementptr inbounds nuw i8, ptr %6, i64 24
+  %8 = load ptr, ptr %7, align 8
+  %9 = tail call noundef zeroext i1 %8(ptr noundef nonnull align 8 dereferenceable(40) %1)
+  %10 = getelementptr inbounds nuw i8, ptr %4, i64 120
+  %11 = zext i1 %9 to i8
+  store i8 %11, ptr %10, align 8, !tbaa !361
   %.pre2.i = load ptr, ptr %5, align 8, !tbaa !290
-  br i1 %10, label %13, label %_ZN7rocksdb6DBIter7SetIterEPNS_20InternalIteratorBaseINS_5SliceEEE.exit
+  br i1 %9, label %13, label %_ZN7rocksdb6DBIter7SetIterEPNS_20InternalIteratorBaseINS_5SliceEEE.exit
 
 13:                                               ; preds = %2
   %14 = load ptr, ptr %.pre2.i, align 8, !tbaa !95
   %15 = getelementptr inbounds nuw i8, ptr %14, i64 88
   %16 = load ptr, ptr %15, align 8
-  %17 = tail call { ptr, i64 } %16(ptr noundef nonnull align 8 dereferenceable(40) %.pre2.i)
+  %17 = tail call { ptr, i64 } %15(ptr noundef nonnull align 8 dereferenceable(40) %.pre2.i)
   %18 = extractvalue { ptr, i64 } %17, 0
   %19 = extractvalue { ptr, i64 } %17, 1
   %20 = getelementptr inbounds nuw i8, ptr %4, i64 96
@@ -2289,12 +2288,12 @@ define linkonce_odr void @_ZN7rocksdb18ArenaWrappedDBIter18SetIterUnderDBIterEPN
   br label %_ZN7rocksdb6DBIter7SetIterEPNS_20InternalIteratorBaseINS_5SliceEEE.exit
 
 _ZN7rocksdb6DBIter7SetIterEPNS_20InternalIteratorBaseINS_5SliceEEE.exit: ; preds = %2, %13
-  %23 = phi ptr [ %.pre.i, %13 ], [ %.pre2.i, %2 ]
+  %23 = phi ptr [ %.pre.i, %12 ], [ %.pre2.i, %2 ]
   %24 = getelementptr inbounds nuw i8, ptr %4, i64 984
   %25 = load ptr, ptr %23, align 8, !tbaa !95
   %26 = getelementptr inbounds nuw i8, ptr %25, i64 152
   %27 = load ptr, ptr %26, align 8
-  tail call void %27(ptr noundef nonnull align 8 dereferenceable(40) %23, ptr noundef nonnull %24)
+  tail call void %26(ptr noundef nonnull align 8 dereferenceable(40) %23, ptr noundef nonnull %24)
   ret void
 }
 
diff --git a/bench/ropey-rs/optimized/30mvp109esc0xeg6.ll b/bench/ropey-rs/optimized/30mvp109esc0xeg6.ll
index abd5590ca1f..16b6882f323 100644
--- a/bench/ropey-rs/optimized/30mvp109esc0xeg6.ll
+++ b/bench/ropey-rs/optimized/30mvp109esc0xeg6.ll
@@ -110,6 +110,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %.val = load ptr, ptr %5, align 8, !nonnull !4, !align !15, !noundef !4
   %6 = getelementptr i8, ptr %5, i64 8
   %.val1 = load i64, ptr %6, align 8, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !16
   call void @_ZN4core3fmt9Formatter10debug_list17h6fd145ef502d86b6E(ptr noalias noundef nonnull sret([16 x i8]) align 8 captures(none) dereferenceable(16) %4, ptr noalias noundef nonnull align 8 dereferenceable(64) %1), !noalias !22
   %.idx.i.i = shl nsw i64 %.val1, 3
@@ -146,6 +147,7 @@ define internal noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug
   %4 = alloca [8 x i8], align 8
   %5 = load ptr, ptr %0, align 8, !nonnull !4, !align !15, !noundef !4
   %.val = load ptr, ptr %5, align 8, !nonnull !4, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %6 = getelementptr inbounds nuw i8, ptr %.val, i64 16
   tail call void @llvm.experimental.noalias.scope.decl(metadata !26)
   %7 = load i8, ptr %6, align 8, !range !29, !alias.scope !26, !noalias !30, !noundef !4
@@ -290,10 +292,9 @@ define hidden noundef nonnull align 8 dereferenceable(16) ptr @_ZN4core3fmt8buil
 ; Function Attrs: nonlazybind uwtable
 define hidden noundef nonnull align 8 dereferenceable(16) ptr @_ZN4core3fmt8builders9DebugList7entries17hd97c7bde1f7a3dd2E(ptr noalias noundef returned align 8 dereferenceable(16) %0, ptr noundef nonnull %1, ptr noundef readnone captures(address) %2) unnamed_addr #6 personality ptr @rust_eh_personality {
   %4 = alloca [8 x i8], align 8
-  %5 = icmp ne ptr %2, null
-  tail call void @llvm.assume(i1 %5)
-  %6 = icmp eq ptr %1, %2
-  br i1 %6, label %._crit_edge, label %.lr.ph
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  %5 = icmp eq ptr %1, %2
+  br i1 %5, label %._crit_edge, label %.lr.ph
 
 ._crit_edge:                                      ; preds = %.lr.ph, %3
   ret ptr %0
diff --git a/bench/ropey-rs/optimized/3dnc959gvadodw9w.ll b/bench/ropey-rs/optimized/3dnc959gvadodw9w.ll
index 9f02b38e49f..69369f7d712 100644
--- a/bench/ropey-rs/optimized/3dnc959gvadodw9w.ll
+++ b/bench/ropey-rs/optimized/3dnc959gvadodw9w.ll
@@ -244,6 +244,7 @@ define hidden void @"_ZN4core3ptr44drop_in_place$LT$ropey..tree..node..Node$GT$1
 "_ZN4core3ptr46drop_in_place$LT$alloc..vec..Vec$LT$u8$GT$$GT$17ha53c611e89e7adbdE.llvm.10316259052761615454.exit.i.i.i.i": ; preds = %5
   %11 = getelementptr inbounds nuw i8, ptr %0, i64 24
   %12 = load ptr, ptr %11, align 8, !alias.scope !97, !nonnull !4, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %12) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %12, i64 noundef %7, i64 noundef 1) #18, !noalias !101
   br label %"_ZN4core3ptr53drop_in_place$LT$ropey..tree..node_text..NodeText$GT$17h06903e8b80578e21E.exit"
 
@@ -265,6 +266,7 @@ define hidden void @"_ZN4core3ptr44drop_in_place$LT$ropey..tree..node..Node$GT$1
   %19 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %.idx.i.i.i = shl nuw nsw i64 %16, 3
   %20 = getelementptr inbounds nuw i8, ptr %19, i64 %.idx.i.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %19) ]
   %21 = icmp eq i8 %15, 0
   br i1 %21, label %"_ZN4core3ptr53drop_in_place$LT$ropey..tree..node_text..NodeText$GT$17h06903e8b80578e21E.exit", label %.lr.ph.i.i.i
 
@@ -390,6 +392,7 @@ define hidden void @"_ZN4core3ptr53drop_in_place$LT$ropey..tree..node_text..Node
 "_ZN4core3ptr46drop_in_place$LT$alloc..vec..Vec$LT$u8$GT$$GT$17ha53c611e89e7adbdE.llvm.10316259052761615454.exit.i.i.i": ; preds = %1
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 16
   %8 = load ptr, ptr %7, align 8, !alias.scope !186, !nonnull !4, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %8, i64 noundef %4, i64 noundef 1) #18, !noalias !190
   br label %"_ZN4core3ptr67drop_in_place$LT$ropey..tree..node_text..inner..NodeSmallString$GT$17h76f674562ae8b056E.exit"
 
@@ -414,6 +417,7 @@ define hidden void @"_ZN4core3ptr61drop_in_place$LT$ropey..tree..node_children..
 "_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$9index_mut17h435e5dd35a2eaf23E.llvm.10316259052761615454.exit.i.i": ; preds = %1
   %.idx.i.i = shl nuw nsw i64 %4, 3
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 %.idx.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   %8 = icmp eq i8 %3, 0
   br i1 %8, label %"_ZN4core3ptr76drop_in_place$LT$ropey..tree..node_children..inner..NodeChildrenInternal$GT$17haf21cb8a7decc8feE.exit", label %.lr.ph.i.i
 
@@ -457,6 +461,7 @@ define hidden void @"_ZN4core3ptr67drop_in_place$LT$ropey..tree..node_text..inne
 "_ZN4core3ptr46drop_in_place$LT$alloc..vec..Vec$LT$u8$GT$$GT$17ha53c611e89e7adbdE.llvm.10316259052761615454.exit.i.i": ; preds = %1
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 16
   %8 = load ptr, ptr %7, align 8, !alias.scope !213, !nonnull !4, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %8, i64 noundef %4, i64 noundef 1) #18, !noalias !217
   br label %"_ZN4core3ptr90drop_in_place$LT$smallvec..SmallVec$LT$ropey..tree..node_text..inner..BackingArray$GT$$GT$17h042faa891899c314E.exit"
 
@@ -532,6 +537,7 @@ define hidden void @"_ZN4core3ptr73drop_in_place$LT$alloc..sync..ArcInner$LT$rop
 "_ZN4core3ptr46drop_in_place$LT$alloc..vec..Vec$LT$u8$GT$$GT$17ha53c611e89e7adbdE.llvm.10316259052761615454.exit.i.i.i.i.i": ; preds = %6
   %12 = getelementptr inbounds nuw i8, ptr %0, i64 40
   %13 = load ptr, ptr %12, align 8, !alias.scope !245, !nonnull !4, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %13) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %13, i64 noundef %8, i64 noundef 1) #18, !noalias !249
   br label %"_ZN4core3ptr44drop_in_place$LT$ropey..tree..node..Node$GT$17h20cd6a5fa0832ca3E.llvm.10316259052761615454.exit"
 
@@ -553,6 +559,7 @@ define hidden void @"_ZN4core3ptr73drop_in_place$LT$alloc..sync..ArcInner$LT$rop
   %20 = getelementptr inbounds nuw i8, ptr %0, i64 24
   %.idx.i.i.i.i = shl nuw nsw i64 %17, 3
   %21 = getelementptr inbounds nuw i8, ptr %20, i64 %.idx.i.i.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %20) ]
   %22 = icmp eq i8 %16, 0
   br i1 %22, label %"_ZN4core3ptr44drop_in_place$LT$ropey..tree..node..Node$GT$17h20cd6a5fa0832ca3E.llvm.10316259052761615454.exit", label %.lr.ph.i.i.i.i
 
@@ -593,6 +600,7 @@ define hidden void @"_ZN4core3ptr76drop_in_place$LT$ropey..tree..node_children..
 "_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$9index_mut17h435e5dd35a2eaf23E.llvm.10316259052761615454.exit.i": ; preds = %1
   %.idx.i = shl nuw nsw i64 %4, 3
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 %.idx.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   %8 = icmp eq i8 %3, 0
   br i1 %8, label %"_ZN97_$LT$ropey..tree..node_children..inner..NodeChildrenInternal$u20$as$u20$core..ops..drop..Drop$GT$4drop17h0810109c904f8a5fE.exit", label %.lr.ph.i
 
@@ -699,6 +707,7 @@ define hidden void @"_ZN4core3ptr90drop_in_place$LT$smallvec..SmallVec$LT$ropey.
 "_ZN4core3ptr46drop_in_place$LT$alloc..vec..Vec$LT$u8$GT$$GT$17ha53c611e89e7adbdE.llvm.10316259052761615454.exit.i": ; preds = %1
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 16
   %8 = load ptr, ptr %7, align 8, !alias.scope !289, !nonnull !4, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %8, i64 noundef %4, i64 noundef 1) #18, !noalias !295
   br label %"_ZN69_$LT$smallvec..SmallVec$LT$A$GT$$u20$as$u20$core..ops..drop..Drop$GT$4drop17hba1f0457f5a4ef8cE.llvm.10316259052761615454.exit"
 
@@ -933,20 +942,18 @@ define hidden void @"_ZN5alloc7raw_vec19RawVec$LT$T$C$A$GT$14current_memory17hd0
 
 ; Function Attrs: inlinehint mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(inaccessiblemem: write) uwtable
 define hidden { i64, ptr } @"_ZN5alloc7raw_vec19RawVec$LT$T$C$A$GT$17from_raw_parts_in17h31a3f1e3234e71fdE.llvm.10316259052761615454"(ptr noundef %0, i64 noundef %1) unnamed_addr #9 {
-  %3 = icmp ne ptr %0, null
-  tail call void @llvm.assume(i1 %3)
-  %4 = insertvalue { i64, ptr } poison, i64 %1, 0
-  %5 = insertvalue { i64, ptr } %4, ptr %0, 1
-  ret { i64, ptr } %5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
+  %3 = insertvalue { i64, ptr } poison, i64 %1, 0
+  %4 = insertvalue { i64, ptr } %3, ptr %0, 1
+  ret { i64, ptr } %4
 }
 
 ; Function Attrs: inlinehint mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(inaccessiblemem: write) uwtable
 define hidden { i64, ptr } @"_ZN5alloc7raw_vec19RawVec$LT$T$C$A$GT$17from_raw_parts_in17h8277551db2175a1dE.llvm.10316259052761615454"(ptr noundef %0, i64 noundef %1) unnamed_addr #9 {
-  %3 = icmp ne ptr %0, null
-  tail call void @llvm.assume(i1 %3)
-  %4 = insertvalue { i64, ptr } poison, i64 %1, 0
-  %5 = insertvalue { i64, ptr } %4, ptr %0, 1
-  ret { i64, ptr } %5
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
+  %3 = insertvalue { i64, ptr } poison, i64 %1, 0
+  %4 = insertvalue { i64, ptr } %3, ptr %0, 1
+  ret { i64, ptr } %4
 }
 
 ; Function Attrs: inlinehint nounwind nonlazybind uwtable
@@ -982,6 +989,7 @@ define hidden void @"_ZN69_$LT$smallvec..SmallVec$LT$A$GT$$u20$as$u20$core..ops.
 "_ZN4core3ptr46drop_in_place$LT$alloc..vec..Vec$LT$u8$GT$$GT$17ha53c611e89e7adbdE.llvm.10316259052761615454.exit": ; preds = %1
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 16
   %8 = load ptr, ptr %7, align 8, !nonnull !4, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %8, i64 noundef %4, i64 noundef 1) #18, !noalias !364
   br label %9
 
@@ -1070,6 +1078,7 @@ define hidden void @"_ZN69_$LT$smallvec..SmallVec$LT$A$GT$$u20$as$u20$core..ops.
   %35 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %36 = load i64, ptr %35, align 8, !noundef !4
   call void @llvm.lifetime.start.p0(ptr nonnull %3)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %34) ]
   store i64 %5, ptr %3, align 8
   %37 = getelementptr inbounds nuw i8, ptr %3, i64 8
   store ptr %34, ptr %37, align 8
@@ -1323,6 +1332,7 @@ define void @"_ZN97_$LT$ropey..tree..node_children..inner..NodeChildrenInternal$
 "_ZN106_$LT$core..ops..range..Range$LT$usize$GT$$u20$as$u20$core..slice..index..SliceIndex$LT$$u5b$T$u5d$$GT$$GT$9index_mut17h435e5dd35a2eaf23E.llvm.10316259052761615454.exit": ; preds = %1
   %.idx = shl nuw nsw i64 %4, 3
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 %.idx
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   %8 = icmp eq i8 %3, 0
   br i1 %8, label %._crit_edge, label %.lr.ph
 
diff --git a/bench/ropey-rs/optimized/598mb8dcqw4tyfm.ll b/bench/ropey-rs/optimized/598mb8dcqw4tyfm.ll
index e444d8c832b..1797453364f 100644
--- a/bench/ropey-rs/optimized/598mb8dcqw4tyfm.ll
+++ b/bench/ropey-rs/optimized/598mb8dcqw4tyfm.ll
@@ -66,6 +66,7 @@ define internal fastcc void @"_ZN4core3ptr44drop_in_place$LT$ropey..tree..node..
   %16 = getelementptr inbounds nuw i8, ptr %0, i64 16
   %17 = load i64, ptr %16, align 8, !alias.scope !18, !noundef !5
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !18
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %15) ]
   store i64 %10, ptr %4, align 8, !noalias !18
   %18 = getelementptr inbounds nuw i8, ptr %4, i64 8
   store ptr %15, ptr %18, align 8, !noalias !18
@@ -161,6 +162,7 @@ define internal fastcc noundef nonnull align 8 dereferenceable(1008) ptr @"_ZN5a
   store i64 1, ptr %20, align 8
   %23 = getelementptr inbounds nuw i8, ptr %20, i64 8
   store i64 1, ptr %23, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %20) ]
   store ptr %20, ptr %6, align 8
   %24 = load ptr, ptr %0, align 8, !nonnull !5, !noundef !5
   %25 = getelementptr inbounds nuw i8, ptr %24, i64 16
@@ -185,6 +187,7 @@ define internal fastcc noundef nonnull align 8 dereferenceable(1008) ptr @"_ZN5a
   %32 = load i64, ptr %31, align 8, !noalias !45, !noundef !5
   call void @llvm.lifetime.end.p0(ptr nonnull %4), !noalias !45
   %33 = getelementptr inbounds i8, ptr %30, i64 %32
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %30) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !51
   %34 = getelementptr inbounds nuw i8, ptr %3, i64 992
   store i64 0, ptr %34, align 8, !alias.scope !54, !noalias !51
@@ -261,6 +264,7 @@ define internal fastcc noundef nonnull align 8 dereferenceable(1008) ptr @"_ZN5a
   store i64 1, ptr %55, align 8
   %59 = getelementptr inbounds nuw i8, ptr %55, i64 8
   store i64 1, ptr %59, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %55) ]
   %60 = getelementptr inbounds nuw i8, ptr %55, i64 16
   %61 = getelementptr inbounds nuw i8, ptr %11, i64 16
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(1008) %60, ptr noundef nonnull align 8 dereferenceable(1008) %61, i64 1008, i1 false)
@@ -1175,6 +1179,7 @@ _ZN5ropey4tree4node4Node9text_info17h9289799a1c03cf13E.exit: ; preds = %37, %_ZN
   %111 = getelementptr inbounds nuw i8, ptr %96, i64 16
   %112 = load i64, ptr %111, align 8, !alias.scope !240, !noundef !5
   call void @llvm.lifetime.start.p0(ptr nonnull %11), !noalias !240
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %110) ]
   store i64 %105, ptr %11, align 8, !noalias !240
   %113 = getelementptr inbounds nuw i8, ptr %11, i64 8
   store ptr %110, ptr %113, align 8, !noalias !240
@@ -1470,6 +1475,7 @@ _ZN5ropey4tree4node4Node9text_info17h9289799a1c03cf13E.exit73: ; preds = %_ZN5ro
   %212 = getelementptr inbounds nuw i8, ptr %197, i64 16
   %213 = load i64, ptr %212, align 8, !alias.scope !292, !noundef !5
   call void @llvm.lifetime.start.p0(ptr nonnull %7), !noalias !292
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %211) ]
   store i64 %206, ptr %7, align 8, !noalias !292
   %214 = getelementptr inbounds nuw i8, ptr %7, i64 8
   store ptr %211, ptr %214, align 8, !noalias !292
@@ -1911,6 +1917,7 @@ _ZN5ropey4tree4node4Node9text_info17h9289799a1c03cf13E.exit100.thread: ; preds =
   store i64 %.lcssa6.i.i93, ptr %156, align 8, !alias.scope !395, !noalias !396
   call void @llvm.lifetime.start.p0(ptr nonnull %17)
   store i64 0, ptr %17, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %126) ]
   %159 = getelementptr inbounds nuw i8, ptr %126, i64 16
   call void @llvm.lifetime.start.p0(ptr nonnull %12)
   br label %167
@@ -1922,6 +1929,7 @@ _ZN5ropey4tree4node4Node9text_info17h9289799a1c03cf13E.exit100: ; preds = %.noex
   %160 = trunc nuw i8 %.pre413 to i1
   call void @llvm.lifetime.start.p0(ptr nonnull %17)
   store i64 0, ptr %17, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.pre) ]
   %161 = getelementptr inbounds nuw i8, ptr %.val.pre, i64 16
   call void @llvm.lifetime.start.p0(ptr nonnull %12)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !397)
@@ -1983,6 +1991,7 @@ _ZN5ropey4tree4node4Node9text_info17h9289799a1c03cf13E.exit.i.i: ; preds = %.lr.
   br i1 %.not.i.i101, label %_ZN5ropey4rope4Rope8get_char17h296e029f71685c1fE.exit.thread5.i, label %181
 
 181:                                              ; preds = %_ZN5ropey4tree4node4Node9text_info17h9289799a1c03cf13E.exit.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val460) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %8), !noalias !413
   tail call void @llvm.experimental.noalias.scope.decl(metadata !418)
   %182 = load i8, ptr %179, align 8, !range !4, !alias.scope !418, !noalias !421, !noundef !5
@@ -2252,6 +2261,7 @@ _ZN11str_indices5chars16to_byte_idx_impl17h0e1ffa1c9b40da34E.exit.i.i: ; preds =
   %308 = add nsw i64 %.sroa.0.4.i.i.i, 1
   %309 = icmp ne i64 %308, %196
   tail call void @llvm.assume(i1 %309)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %305) ]
   %310 = load i8, ptr %305, align 1, !noalias !443, !noundef !5
   %311 = shl nuw nsw i32 %307, 6
   %312 = and i8 %310, 63
@@ -2269,6 +2279,7 @@ _ZN11str_indices5chars16to_byte_idx_impl17h0e1ffa1c9b40da34E.exit.i.i: ; preds =
   %319 = add nsw i64 %.sroa.0.4.i.i.i, 2
   %320 = icmp ne i64 %319, %196
   tail call void @llvm.assume(i1 %320)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %318) ]
   %321 = load i8, ptr %318, align 1, !noalias !443, !noundef !5
   %322 = shl nuw nsw i32 %313, 6
   %323 = and i8 %321, 63
@@ -2284,6 +2295,7 @@ _ZN11str_indices5chars16to_byte_idx_impl17h0e1ffa1c9b40da34E.exit.i.i: ; preds =
   %330 = add nsw i64 %.sroa.0.4.i.i.i, 3
   %331 = icmp ne i64 %330, %196
   tail call void @llvm.assume(i1 %331)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %329) ]
   %332 = load i8, ptr %329, align 1, !noalias !443, !noundef !5
   %333 = shl nuw nsw i32 %307, 18
   %334 = and i32 %333, 1835008
@@ -4394,6 +4406,7 @@ _ZN5ropey4rope4Rope22pull_up_singular_nodes17hb14933cc99a419cfE.exit._ZN5ropey4r
   %79 = getelementptr inbounds nuw i8, ptr %12, i64 16
   %80 = load i64, ptr %79, align 8, !alias.scope !972, !noundef !5
   call void @llvm.lifetime.start.p0(ptr nonnull %7), !noalias !972
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %78) ]
   store i64 %73, ptr %7, align 8, !noalias !972
   %81 = getelementptr inbounds nuw i8, ptr %7, i64 8
   store ptr %78, ptr %81, align 8, !noalias !972
@@ -4533,6 +4546,7 @@ _ZN5ropey4rope4Rope22pull_up_singular_nodes17hb14933cc99a419cfE.exit22: ; preds
   %132 = getelementptr inbounds nuw i8, ptr %118, i64 16
   %133 = load i64, ptr %132, align 8, !alias.scope !1020, !noundef !5
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !1020
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %131) ]
   store i64 %126, ptr %4, align 8, !noalias !1020
   %134 = getelementptr inbounds nuw i8, ptr %4, i64 8
   store ptr %131, ptr %134, align 8, !noalias !1020
diff --git a/bench/ropey-rs/optimized/q87dnuin1j2jq4x.ll b/bench/ropey-rs/optimized/q87dnuin1j2jq4x.ll
index 6af0975f4a2..61bdf836980 100644
--- a/bench/ropey-rs/optimized/q87dnuin1j2jq4x.ll
+++ b/bench/ropey-rs/optimized/q87dnuin1j2jq4x.ll
@@ -20,32 +20,31 @@ target triple = "x86_64-unknown-linux-gnu"
 
 ; Function Attrs: nonlazybind uwtable
 define hidden void @"_ZN132_$LT$alloc..vec..Vec$LT$T$C$A$GT$$u20$as$u20$alloc..vec..spec_extend..SpecExtend$LT$$RF$T$C$core..slice..iter..Iter$LT$T$GT$$GT$$GT$11spec_extend17h436592eca368d2f9E.llvm.11761237816275622986"(ptr noalias noundef align 8 dereferenceable(24) %0, ptr noundef nonnull %1, ptr noundef %2) unnamed_addr #0 {
-  %4 = icmp ne ptr %2, null
-  tail call void @llvm.assume(i1 %4)
-  %5 = ptrtoint ptr %2 to i64
-  %6 = ptrtoint ptr %1 to i64
-  %7 = sub nuw i64 %5, %6
-  %8 = getelementptr inbounds nuw i8, ptr %0, i64 16
-  %9 = load i64, ptr %8, align 8, !alias.scope !4, !noundef !9
-  %10 = load i64, ptr %0, align 8, !alias.scope !4, !noundef !9
-  %11 = sub i64 %10, %9
-  %12 = icmp ugt i64 %7, %11
-  br i1 %12, label %13, label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$15append_elements17hab39dd1fb96859a6E.llvm.11761237816275622986.exit"
-
-13:                                               ; preds = %3
-  tail call void @"_ZN5alloc7raw_vec19RawVec$LT$T$C$A$GT$7reserve21do_reserve_and_handle17he044785a704de353E"(ptr noalias noundef nonnull align 8 dereferenceable(24) %0, i64 noundef %9, i64 noundef %7)
-  %.pre.i = load i64, ptr %8, align 8, !alias.scope !10
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  %4 = ptrtoint ptr %2 to i64
+  %5 = ptrtoint ptr %1 to i64
+  %6 = sub nuw i64 %4, %5
+  %7 = getelementptr inbounds nuw i8, ptr %0, i64 16
+  %8 = load i64, ptr %7, align 8, !alias.scope !4, !noundef !9
+  %9 = load i64, ptr %0, align 8, !alias.scope !4, !noundef !9
+  %10 = sub i64 %9, %8
+  %11 = icmp ugt i64 %6, %10
+  br i1 %11, label %12, label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$15append_elements17hab39dd1fb96859a6E.llvm.11761237816275622986.exit"
+
+12:                                               ; preds = %3
+  tail call void @"_ZN5alloc7raw_vec19RawVec$LT$T$C$A$GT$7reserve21do_reserve_and_handle17he044785a704de353E"(ptr noalias noundef nonnull align 8 dereferenceable(24) %0, i64 noundef %8, i64 noundef %6)
+  %.pre.i = load i64, ptr %7, align 8, !alias.scope !10
   br label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$15append_elements17hab39dd1fb96859a6E.llvm.11761237816275622986.exit"
 
-"_ZN5alloc3vec16Vec$LT$T$C$A$GT$15append_elements17hab39dd1fb96859a6E.llvm.11761237816275622986.exit": ; preds = %3, %13
-  %14 = phi i64 [ %9, %3 ], [ %.pre.i, %13 ]
+"_ZN5alloc3vec16Vec$LT$T$C$A$GT$15append_elements17hab39dd1fb96859a6E.llvm.11761237816275622986.exit": ; preds = %3, %12
+  %14 = phi i64 [ %8, %3 ], [ %.pre.i, %12 ]
   %15 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %16 = load ptr, ptr %15, align 8, !alias.scope !10, !nonnull !9, !noundef !9
   %17 = getelementptr inbounds i8, ptr %16, i64 %14
-  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %17, ptr nonnull readonly align 1 %1, i64 %7, i1 false)
-  %18 = load i64, ptr %8, align 8, !alias.scope !10, !noundef !9
-  %19 = add i64 %18, %7
-  store i64 %19, ptr %8, align 8, !alias.scope !10
+  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %17, ptr nonnull readonly align 1 %1, i64 %6, i1 false)
+  %18 = load i64, ptr %7, align 8, !alias.scope !10, !noundef !9
+  %19 = add i64 %18, %6
+  store i64 %19, ptr %7, align 8, !alias.scope !10
   ret void
 }
 
@@ -57,10 +56,12 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %.val = load ptr, ptr %5, align 8, !nonnull !9, !align !11, !noundef !9
   %6 = getelementptr i8, ptr %5, i64 8
   %.val1 = load i64, ptr %6, align 8, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !12
   call void @_ZN4core3fmt9Formatter10debug_list17h6fd145ef502d86b6E(ptr noalias noundef nonnull sret([16 x i8]) align 8 captures(none) dereferenceable(16) %4, ptr noalias noundef nonnull align 8 dereferenceable(64) %1), !noalias !18
   %.idx.i.i = shl nsw i64 %.val1, 5
   %7 = getelementptr inbounds i8, ptr %.val, i64 %.idx.i.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %7) ]
   %8 = icmp eq i64 %.val1, 0
   br i1 %8, label %"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$GT$3fmt17hfe2e676908234756E.exit", label %.lr.ph.i.i.i
 
diff --git a/bench/ruby/optimized/vm_trace.ll b/bench/ruby/optimized/vm_trace.ll
index 76c73085acd..5f65ca1bfa4 100644
--- a/bench/ruby/optimized/vm_trace.ll
+++ b/bench/ruby/optimized/vm_trace.ll
@@ -353,7 +353,8 @@ rb_threadptr_add_event_hook.exit:                 ; preds = %4
   store i32 0, ptr %16, align 8, !tbaa !37
   store ptr %7, ptr %15, align 8, !tbaa !38
   %17 = getelementptr i8, ptr %6, i64 48
-  %.val.i = load ptr, ptr %17, align 8, !tbaa !39, !nonnull !32, !noundef !32
+  %.val.i = load ptr, ptr %17, align 8, !tbaa !39
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   %18 = getelementptr inbounds nuw i8, ptr %.val.i, i64 24
   %19 = load ptr, ptr %18, align 8, !tbaa !48
   %20 = getelementptr inbounds nuw i8, ptr %19, i64 16
@@ -398,7 +399,8 @@ rb_add_event_hook2.exit:                          ; preds = %3
   %13 = tail call align 8 ptr @llvm.threadlocal.address.p0(ptr align 8 @ruby_current_ec)
   %14 = load ptr, ptr %13, align 8, !tbaa !33
   %15 = getelementptr i8, ptr %14, i64 48
-  %.val.i = load ptr, ptr %15, align 8, !tbaa !39, !nonnull !32, !noundef !32
+  %.val.i = load ptr, ptr %15, align 8, !tbaa !39
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   %16 = getelementptr inbounds nuw i8, ptr %.val.i, i64 24
   %17 = load ptr, ptr %16, align 8, !tbaa !48
   %18 = getelementptr inbounds nuw i8, ptr %17, i64 16
@@ -443,7 +445,8 @@ alloc_event_hook.exit:                            ; preds = %4
   %14 = tail call align 8 ptr @llvm.threadlocal.address.p0(ptr align 8 @ruby_current_ec)
   %15 = load ptr, ptr %14, align 8, !tbaa !33
   %16 = getelementptr i8, ptr %15, i64 48
-  %.val = load ptr, ptr %16, align 8, !tbaa !39, !nonnull !32, !noundef !32
+  %.val = load ptr, ptr %16, align 8, !tbaa !39
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %17 = getelementptr inbounds nuw i8, ptr %.val, i64 24
   %18 = load ptr, ptr %17, align 8, !tbaa !48
   %19 = getelementptr inbounds nuw i8, ptr %18, i64 16
@@ -489,7 +492,8 @@ rb_threadptr_add_event_hook.exit:                 ; preds = %5
   store i32 0, ptr %17, align 8, !tbaa !37
   store ptr %8, ptr %16, align 8, !tbaa !38
   %18 = getelementptr i8, ptr %7, i64 48
-  %.val.i = load ptr, ptr %18, align 8, !tbaa !39, !nonnull !32, !noundef !32
+  %.val.i = load ptr, ptr %18, align 8, !tbaa !39
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   %19 = getelementptr inbounds nuw i8, ptr %.val.i, i64 24
   %20 = load ptr, ptr %19, align 8, !tbaa !48
   %21 = getelementptr inbounds nuw i8, ptr %20, i64 16
@@ -2696,7 +2700,8 @@ rb_add_event_hook2.exit:                          ; preds = %29
   %.sink21 = phi ptr [ %34, %rb_add_event_hook2.exit ], [ %23, %rb_thread_add_event_hook2.exit ]
   %.sink16 = phi i32 [ %30, %rb_add_event_hook2.exit ], [ %16, %rb_thread_add_event_hook2.exit ]
   %43 = getelementptr i8, ptr %.sink26, i64 48
-  %.val.i = load ptr, ptr %43, align 8, !tbaa !39, !nonnull !32, !noundef !32
+  %.val.i = load ptr, ptr %43, align 8, !tbaa !39
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   %44 = getelementptr inbounds nuw i8, ptr %.val.i, i64 24
   %45 = load ptr, ptr %44, align 8, !tbaa !48
   %46 = getelementptr inbounds nuw i8, ptr %45, i64 16
@@ -5147,7 +5152,8 @@ rb_remove_event_hook.exit:                        ; preds = %._crit_edge.i.i, %2
   store i32 0, ptr %42, align 8, !tbaa !37
   %43 = load ptr, ptr %3, align 8, !tbaa !33
   %44 = getelementptr i8, ptr %43, i64 48
-  %.val.i.i = load ptr, ptr %44, align 8, !tbaa !39, !nonnull !32, !noundef !32
+  %.val.i.i = load ptr, ptr %44, align 8, !tbaa !39
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i.i) ]
   %45 = getelementptr inbounds nuw i8, ptr %.val.i.i, i64 24
   %46 = load ptr, ptr %45, align 8, !tbaa !48
   %47 = getelementptr inbounds nuw i8, ptr %46, i64 16
@@ -5284,7 +5290,8 @@ thread_add_trace_func.exit:                       ; preds = %42
   %51 = getelementptr inbounds nuw i8, ptr %46, i64 40
   store i32 0, ptr %51, align 8, !tbaa !37
   store ptr %5, ptr %50, align 8, !tbaa !38
-  %.val.i.i = load ptr, ptr %6, align 8, !tbaa !39, !nonnull !32, !noundef !32
+  %.val.i.i = load ptr, ptr %6, align 8, !tbaa !39
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i.i) ]
   %52 = getelementptr inbounds nuw i8, ptr %.val.i.i, i64 24
   %53 = load ptr, ptr %52, align 8, !tbaa !48
   %54 = getelementptr inbounds nuw i8, ptr %53, i64 16
@@ -5331,7 +5338,8 @@ thread_add_trace_func.exit:                       ; preds = %2
   store i32 0, ptr %14, align 8, !tbaa !37
   store ptr %5, ptr %13, align 8, !tbaa !38
   %15 = getelementptr i8, ptr %4, i64 48
-  %.val.i.i = load ptr, ptr %15, align 8, !tbaa !39, !nonnull !32, !noundef !32
+  %.val.i.i = load ptr, ptr %15, align 8, !tbaa !39
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i.i) ]
   %16 = getelementptr inbounds nuw i8, ptr %.val.i.i, i64 24
   %17 = load ptr, ptr %16, align 8, !tbaa !48
   %18 = getelementptr inbounds nuw i8, ptr %17, i64 16
diff --git a/bench/salsa-rs/optimized/35mx14hjf8oh90noer0x3ymew.ll b/bench/salsa-rs/optimized/35mx14hjf8oh90noer0x3ymew.ll
index a47a9b62ff7..3f9411a6f9d 100644
--- a/bench/salsa-rs/optimized/35mx14hjf8oh90noer0x3ymew.ll
+++ b/bench/salsa-rs/optimized/35mx14hjf8oh90noer0x3ymew.ll
@@ -363,8 +363,9 @@ define internal noundef zeroext i1 @_ZN4core3fmt5Write9write_fmt17hdfc15abedd9df
   ret i1 %3
 }
 
-; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read) uwtable
+; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: write) uwtable
 define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h159e1867fda72a7cE(ptr noalias noundef nonnull readonly align 1 captures(none) %0, ptr noalias noundef readonly align 4 captures(none) dereferenceable(4) %1) unnamed_addr #2 personality ptr @rust_eh_personality {
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i32, ptr %1, align 4, !noalias !39, !noundef !3
   %3 = zext i32 %.val.i to i64
   %4 = mul i64 %3, -1065810590584100411
@@ -372,8 +373,9 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h159e1867fda72a7
   ret i64 %5
 }
 
-; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read) uwtable
+; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: write) uwtable
 define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h1e17d21150f52b02E(ptr noalias noundef nonnull readonly align 1 captures(none) %0, ptr noalias noundef readonly align 4 captures(none) dereferenceable(4) %1) unnamed_addr #2 personality ptr @rust_eh_personality {
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i32, ptr %1, align 4, !range !42, !noalias !43, !noundef !3
   %3 = zext i32 %.val.i to i64
   %4 = mul i64 %3, -1065810590584100411
@@ -381,16 +383,18 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h1e17d21150f52b0
   ret i64 %5
 }
 
-; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read) uwtable
+; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: write) uwtable
 define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h7f7d654077a360bdE(ptr noalias noundef nonnull readonly align 1 captures(none) %0, ptr noalias noundef readonly align 8 captures(none) dereferenceable(8) %1) unnamed_addr #2 personality ptr @rust_eh_personality {
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i64, ptr %1, align 8, !range !46, !noalias !47, !noundef !3
   %3 = mul i64 %.val.i, -1065810590584100411
   %4 = tail call noundef i64 @llvm.fshl.i64(i64 %3, i64 %3, i64 26)
   ret i64 %4
 }
 
-; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read) uwtable
+; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: write) uwtable
 define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17hed7c2a8e913fc00bE(ptr noalias noundef nonnull readonly align 1 captures(none) %0, ptr noalias noundef readonly align 4 captures(none) dereferenceable(8) %1) unnamed_addr #2 personality ptr @rust_eh_personality {
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load i32, ptr %1, align 4, !range !42, !noalias !50, !noundef !3
   %3 = getelementptr inbounds nuw i8, ptr %1, i64 4
   %.val1.i = load i32, ptr %3, align 4, !noalias !50, !noundef !3
@@ -445,6 +449,7 @@ define hidden void @"_ZN5alloc3vec16Vec$LT$T$C$A$GT$11resize_with17h9ec1ef132d96
   br i1 %20, label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$14extend_trusted17ha90d52c797e78adcE.exit", label %16
 
 "_ZN5alloc3vec16Vec$LT$T$C$A$GT$14extend_trusted17ha90d52c797e78adcE.exit": ; preds = %16
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %4) ]
   store i64 %19, ptr %4, align 8, !alias.scope !59, !noalias !71
   br label %"_ZN4core3ptr83drop_in_place$LT$$u5b$alloc..vec..Vec$LT$salsa..zalsa..IngredientIndex$GT$$u5d$$GT$17he9272eb733861d96E.exit"
 
@@ -732,7 +737,8 @@ define hidden void @"_ZN5alloc3vec16Vec$LT$T$C$A$GT$6resize17hc41b86dc214e83b0E"
   %storemerge.lcssa16.i = phi i64 [ %22, %._crit_edge.thread.i ], [ %15, %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h59e8b04981d518b1E.exit.i" ]
   store i32 %2, ptr %.sroa.0.0.lcssa17.i, align 4
   %23 = add i64 %storemerge.lcssa16.i, 1
-  br label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$11extend_with17h6f6eeee5879a3705E.exit"
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %5) ]
+  br label %26
 
 .lr.ph.i:                                         ; preds = %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h59e8b04981d518b1E.exit.i", %.lr.ph.i
   %.sroa.0.010.i = phi ptr [ %25, %.lr.ph.i ], [ %19, %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h59e8b04981d518b1E.exit.i" ]
@@ -744,7 +750,7 @@ define hidden void @"_ZN5alloc3vec16Vec$LT$T$C$A$GT$6resize17hc41b86dc214e83b0E"
   br i1 %exitcond.not.i, label %._crit_edge.thread.i, label %.lr.ph.i
 
 "_ZN5alloc3vec16Vec$LT$T$C$A$GT$11extend_with17h6f6eeee5879a3705E.exit": ; preds = %4, %._crit_edge.i
-  %storemerge = phi i64 [ %1, %4 ], [ %23, %._crit_edge.i ]
+  %storemerge = phi i64 [ %23, %._crit_edge.i ], [ %1, %4 ]
   store i64 %storemerge, ptr %5, align 8
   ret void
 }
@@ -912,8 +918,8 @@ define hidden void @"_ZN98_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..s
   %6 = alloca [24 x i8], align 8
   %7 = alloca [24 x i8], align 8
   call void @llvm.lifetime.start.p0(ptr nonnull %7), !noalias !128
-  %8 = icmp ne ptr %2, null
-  tail call void @llvm.assume(i1 %8)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %9 = ptrtoint ptr %2 to i64
   %10 = ptrtoint ptr %1 to i64
   %11 = sub nuw i64 %9, %10
@@ -942,6 +948,8 @@ define hidden void @"_ZN98_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..s
   store ptr %20, ptr %22, align 8, !noalias !128
   %23 = getelementptr inbounds nuw i8, ptr %7, i64 16
   store i64 0, ptr %23, align 8, !noalias !128
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %5), !noalias !136
   store ptr %23, ptr %5, align 8, !noalias !145
   %.sroa.4.0..sroa_idx.i.i.i = getelementptr inbounds nuw i8, ptr %5, i64 8
@@ -955,7 +963,7 @@ define hidden void @"_ZN98_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..s
   %25 = landingpad { ptr, i32 }
           cleanup
   invoke void @"_ZN4core3ptr78drop_in_place$LT$alloc..vec..Vec$LT$salsa..active_query..CapturedQuery$GT$$GT$17h54309d6316355cdbE"(ptr noalias noundef nonnull align 8 dereferenceable(24) %7) #14
-          to label %28 unwind label %26, !noalias !128
+          to label %27 unwind label %26, !noalias !128
 
 26:                                               ; preds = %24
   %27 = landingpad { ptr, i32 }
@@ -1109,6 +1117,7 @@ define hidden void @"_ZN98_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..s
   %57 = landingpad { ptr, i32 }
           cleanup
   store ptr %59, ptr %6, align 8, !alias.scope !192, !noalias !189
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %36) ]
   store i64 %.val3.i.i.i.i.i.i, ptr %36, align 8, !alias.scope !170, !noalias !194
   invoke void @"_ZN4core3ptr117drop_in_place$LT$alloc..vec..drain..Drain$LT$indexmap..Bucket$LT$salsa..zalsa_local..QueryEdge$C$$LP$$RP$$GT$$GT$$GT$17haf47ec01f04f88b9E"(ptr noalias noundef nonnull align 8 dereferenceable(40) %6) #14
           to label %.body.i unwind label %65, !noalias !195
@@ -1171,6 +1180,7 @@ _ZN4core4iter6traits8iterator8Iterator4fold17h0630ac1c34c1c65aE.exit.loopexit.i.
 
 "_ZN5alloc3vec16Vec$LT$T$C$A$GT$14extend_trusted17h03aaa80852199ad4E.exit.i.i": ; preds = %_ZN4core4iter6traits8iterator8Iterator4fold17h0630ac1c34c1c65aE.exit.loopexit.i.i.i.i.i, %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17hd801353fc9fa1c9cE.exit.i.i.i"
   %.val5.i.i.i.i.i.i = phi i64 [ %51, %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17hd801353fc9fa1c9cE.exit.i.i.i" ], [ %.val5.i.ph.i.i.i.i.i, %_ZN4core4iter6traits8iterator8Iterator4fold17h0630ac1c34c1c65aE.exit.loopexit.i.i.i.i.i ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %36) ]
   store i64 %.val5.i.i.i.i.i.i, ptr %36, align 8, !alias.scope !170, !noalias !194
   invoke void @"_ZN4core3ptr117drop_in_place$LT$alloc..vec..drain..Drain$LT$indexmap..Bucket$LT$salsa..zalsa_local..QueryEdge$C$$LP$$RP$$GT$$GT$$GT$17haf47ec01f04f88b9E"(ptr noalias noundef nonnull align 8 dereferenceable(40) %6)
           to label %"_ZN111_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..spec_from_iter_nested..SpecFromIterNested$LT$T$C$I$GT$$GT$9from_iter17ha33e24eba77344f9E.exit" unwind label %71, !noalias !152
@@ -1390,7 +1400,7 @@ declare void @llvm.experimental.noalias.scope.decl(metadata) #12
 
 attributes #0 = { nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #1 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #2 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #2 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: write) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #3 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
 attributes #4 = { nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #5 = { cold minsize noreturn nounwind nonlazybind optsize uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
diff --git a/bench/salsa-rs/optimized/bfvulplr01a8w79gvhbwzr5ai.ll b/bench/salsa-rs/optimized/bfvulplr01a8w79gvhbwzr5ai.ll
index 71d0c1ef767..94b75eb8b35 100644
--- a/bench/salsa-rs/optimized/bfvulplr01a8w79gvhbwzr5ai.ll
+++ b/bench/salsa-rs/optimized/bfvulplr01a8w79gvhbwzr5ai.ll
@@ -69,6 +69,7 @@ define internal void @"_ZN3std4sync6poison4once4Once15call_once_force28_$u7b$$u7
   br i1 %.not, label %7, label %4, !prof !5
 
 4:                                                ; preds = %2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.0.copyload) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !6)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !9)
   %.sroa.0.0.copyload.i.i.i = load ptr, ptr %.sroa.0.0.copyload, align 8, !alias.scope !12, !noalias !13
@@ -84,8 +85,7 @@ define internal void @"_ZN3std4sync6poison4once4Once15call_once_force28_$u7b$$u7
   %.sroa.5.0..sroa_idx.i.i.i = getelementptr inbounds nuw i8, ptr %.sroa.0.0.copyload, i64 8
   call void @llvm.lifetime.start.p0(ptr nonnull %.sroa.45.i)
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(16) %.sroa.45.i, ptr noundef nonnull align 8 dereferenceable(16) %.sroa.5.0..sroa_idx.i.i.i, i64 16, i1 false)
-  %6 = icmp ne ptr %.sroa.5.sroa.0.0.copyload, null
-  tail call void @llvm.assume(i1 %6)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.5.sroa.0.0.copyload) ]
   store ptr %.sroa.0.0.copyload.i.i.i, ptr %.sroa.5.sroa.0.0.copyload, align 8
   %.sroa.45.0..8.val.sroa_idx.i = getelementptr inbounds nuw i8, ptr %.sroa.5.sroa.0.0.copyload, i64 8
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(16) %.sroa.45.0..8.val.sroa_idx.i, ptr noundef nonnull align 8 dereferenceable(16) %.sroa.45.i, i64 16, i1 false)
@@ -138,6 +138,7 @@ define internal void @"_ZN4core3ops8function6FnOnce40call_once$u7b$$u7b$vtable.s
   br i1 %.not.i.i, label %6, label %4, !prof !5
 
 4:                                                ; preds = %2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.0.copyload.i.i) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !27)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !30)
   %.sroa.0.0.copyload.i.i.i.i.i = load ptr, ptr %.sroa.0.0.copyload.i.i, align 8, !alias.scope !33, !noalias !34
@@ -157,8 +158,7 @@ _ZN4core3ops8function6FnOnce9call_once17h1836a743e5b97eafE.exit: ; preds = %4
   %.sroa.5.0..sroa_idx.i.i.i.i.i = getelementptr inbounds nuw i8, ptr %.sroa.0.0.copyload.i.i, i64 8
   call void @llvm.lifetime.start.p0(ptr nonnull %.sroa.45.i.i.i)
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(16) %.sroa.45.i.i.i, ptr noundef nonnull align 8 dereferenceable(16) %.sroa.5.0..sroa_idx.i.i.i.i.i, i64 16, i1 false), !noalias !38
-  %7 = icmp ne ptr %.sroa.5.sroa.0.0.copyload.i.i, null
-  tail call void @llvm.assume(i1 %7)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.5.sroa.0.0.copyload.i.i) ]
   store ptr %.sroa.0.0.copyload.i.i.i.i.i, ptr %.sroa.5.sroa.0.0.copyload.i.i, align 8, !noalias !38
   %.sroa.45.0..8.val.sroa_idx.i.i.i = getelementptr inbounds nuw i8, ptr %.sroa.5.sroa.0.0.copyload.i.i, i64 8
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(16) %.sroa.45.0..8.val.sroa_idx.i.i.i, ptr noundef nonnull align 8 dereferenceable(16) %.sroa.45.i.i.i, i64 16, i1 false), !noalias !38
@@ -363,6 +363,7 @@ define void @_ZN5salsa8function4sync9SyncTable9try_claim17hc3347ac797fe07c9E(ptr
   store i32 %3, ptr %.sroa.59.0..sroa_idx, align 8
   %.sroa.6.0..sroa_idx = getelementptr inbounds nuw i8, ptr %0, i64 20
   store i8 0, ptr %.sroa.6.0..sroa_idx, align 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %42 = cmpxchg ptr %1, i8 1, i8 0 release monotonic, align 1
   %43 = extractvalue { i8, i1 } %42, 1
   br i1 %43, label %"_ZN4core3ptr211drop_in_place$LT$lock_api..mutex..MutexGuard$LT$parking_lot..raw_mutex..RawMutex$C$std..collections..hash..map..HashMap$LT$salsa..id..Id$C$salsa..function..sync..SyncState$C$rustc_hash..FxBuildHasher$GT$$GT$$GT$17h5d44fd46d70a7ec2E.exit", label %44, !prof !20
@@ -382,6 +383,7 @@ define void @_ZN5salsa8function4sync9SyncTable9try_claim17hc3347ac797fe07c9E(ptr
 
 .thread:                                          ; preds = %38, %.thread28
   %.pn27 = phi { ptr, i32 } [ %lpad.thr_comm, %.thread28 ], [ %39, %38 ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %47 = cmpxchg ptr %1, i8 1, i8 0 release monotonic, align 1
   %48 = extractvalue { i8, i1 } %47, 1
   br i1 %48, label %"_ZN4core3ptr211drop_in_place$LT$lock_api..mutex..MutexGuard$LT$parking_lot..raw_mutex..RawMutex$C$std..collections..hash..map..HashMap$LT$salsa..id..Id$C$salsa..function..sync..SyncState$C$rustc_hash..FxBuildHasher$GT$$GT$$GT$17h5d44fd46d70a7ec2E.exit23", label %49, !prof !20
@@ -412,6 +414,7 @@ define hidden void @_ZN5salsa8function4sync10ClaimGuard35remove_from_map_and_unb
 12:                                               ; preds = %36, %33, %19, %8
   %13 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3) ]
   %14 = cmpxchg ptr %3, i8 1, i8 0 release monotonic, align 1
   %15 = extractvalue { i8, i1 } %14, 1
   br i1 %15, label %"_ZN4core3ptr211drop_in_place$LT$lock_api..mutex..MutexGuard$LT$parking_lot..raw_mutex..RawMutex$C$std..collections..hash..map..HashMap$LT$salsa..id..Id$C$salsa..function..sync..SyncState$C$rustc_hash..FxBuildHasher$GT$$GT$$GT$17h5d44fd46d70a7ec2E.exit", label %16, !prof !20
@@ -435,6 +438,7 @@ define hidden void @_ZN5salsa8function4sync10ClaimGuard35remove_from_map_and_unb
   unreachable
 
 21:                                               ; preds = %36, %17
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3) ]
   %22 = cmpxchg ptr %3, i8 1, i8 0 release monotonic, align 1
   %23 = extractvalue { i8, i1 } %22, 1
   br i1 %23, label %"_ZN4core3ptr211drop_in_place$LT$lock_api..mutex..MutexGuard$LT$parking_lot..raw_mutex..RawMutex$C$std..collections..hash..map..HashMap$LT$salsa..id..Id$C$salsa..function..sync..SyncState$C$rustc_hash..FxBuildHasher$GT$$GT$$GT$17h5d44fd46d70a7ec2E.exit6", label %24, !prof !20
@@ -870,6 +874,7 @@ _ZN11parking_lot10raw_rwlock9RawRwLock20try_lock_shared_fast17h3d018d9c9ce997a4E
 13:                                               ; preds = %.invoke
   %14 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %4) ]
   %15 = atomicrmw sub ptr %4, i64 16 release, align 8
   %16 = and i64 %15, -14
   %17 = icmp eq i64 %16, 18
@@ -901,6 +906,7 @@ _ZN11parking_lot10raw_rwlock9RawRwLock20try_lock_shared_fast17h3d018d9c9ce997a4E
   %34 = load ptr, ptr %33, align 8, !nonnull !3, !noundef !3
   %35 = getelementptr inbounds nuw i32, ptr %34, i64 %28
   %36 = load i32, ptr %35, align 4, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %4) ]
   %37 = atomicrmw sub ptr %4, i64 16 release, align 8
   %38 = and i64 %37, -14
   %39 = icmp eq i64 %38, 18
@@ -947,6 +953,7 @@ define noundef i32 @_ZN5salsa5zalsa5Zalsa26next_memo_ingredient_index17hefc79685
 9:                                                ; preds = %36, %32, %25, %19
   %10 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %4) ]
   %11 = cmpxchg ptr %4, i64 8, i64 0 release monotonic, align 8
   %12 = extractvalue { i64, i1 } %11, 1
   br i1 %12, label %"_ZN4core3ptr175drop_in_place$LT$lock_api..rwlock..RwLockWriteGuard$LT$parking_lot..raw_rwlock..RawRwLock$C$alloc..vec..Vec$LT$alloc..vec..Vec$LT$salsa..zalsa..IngredientIndex$GT$$GT$$GT$$GT$17hc268aa1d7ac90c8eE.exit", label %13, !prof !20
@@ -1014,6 +1021,7 @@ define noundef i32 @_ZN5salsa5zalsa5Zalsa26next_memo_ingredient_index17hefc79685
   store i32 %2, ptr %40, align 4
   %41 = add nuw nsw i64 %29, 1
   store i64 %41, ptr %28, align 8, !alias.scope !61
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %4) ]
   %42 = cmpxchg ptr %4, i64 8, i64 0 release monotonic, align 8
   %43 = extractvalue { i64, i1 } %42, 1
   br i1 %43, label %"_ZN4core3ptr175drop_in_place$LT$lock_api..rwlock..RwLockWriteGuard$LT$parking_lot..raw_rwlock..RawRwLock$C$alloc..vec..Vec$LT$alloc..vec..Vec$LT$salsa..zalsa..IngredientIndex$GT$$GT$$GT$$GT$17hc268aa1d7ac90c8eE.exit9", label %44, !prof !20
diff --git a/bench/serde-rs-json/optimized/36shr7j8gl5gy6fn.ll b/bench/serde-rs-json/optimized/36shr7j8gl5gy6fn.ll
index 42b6268825b..82c5d63cdba 100644
--- a/bench/serde-rs-json/optimized/36shr7j8gl5gy6fn.ll
+++ b/bench/serde-rs-json/optimized/36shr7j8gl5gy6fn.ll
@@ -28,6 +28,7 @@ define hidden noundef ptr @_ZN3std2io5Write9write_all17h6ffa51b6097a75eaE(ptr no
   call void @llvm.experimental.noalias.scope.decl(metadata !4)
   %9 = call noundef nonnull ptr @_ZN3std2io5error5Error3new17h33be6581caccd802E(i8 noundef 39, ptr noalias noundef nonnull readonly align 1 @anon.7b12c2ab9e1ce74a96d00cd7e4c1ea31.28.llvm.8370777945629324, i64 noundef 9), !noalias !14
   %10 = ptrtoint ptr %9 to i64
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %9) ]
   %11 = and i64 %10, 3
   switch i64 %11, label %default.unreachable [
     i64 2, label %12
@@ -134,6 +135,7 @@ define hidden noundef zeroext i1 @"_ZN48_$LT$$u5b$T$u5d$$u20$as$u20$core..fmt..D
   call void @_ZN4core3fmt9Formatter10debug_list17h1616b9a56f5bf339E(ptr noalias noundef nonnull sret({ { ptr, i8, i8, [6 x i8] } }) align 8 captures(none) dereferenceable(16) %5, ptr noalias noundef nonnull align 8 dereferenceable(64) %2)
   %.idx = shl nsw i64 %1, 5
   %6 = getelementptr inbounds i8, ptr %0, i64 %.idx
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
   %7 = icmp eq i64 %1, 0
   br i1 %7, label %_ZN4core3fmt8builders9DebugList7entries17h98a615cf2a9210e6E.exit, label %.lr.ph.i
 
@@ -375,8 +377,7 @@ define hidden void @"_ZN5alloc11collections5btree8navigate75LazyLeafRange$LT$all
   br label %13
 
 7:                                                ; preds = %4
-  %8 = icmp ne ptr %.sroa.4.sroa.4.0.copyload, null
-  tail call void @llvm.assume(i1 %8)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.4.sroa.4.0.copyload) ]
   %.not11.i = icmp eq i64 %.sroa.4.sroa.5.0.copyload, 0
   br i1 %.not11.i, label %"_ZN5alloc11collections5btree8navigate142_$LT$impl$u20$alloc..collections..btree..node..NodeRef$LT$BorrowType$C$K$C$V$C$alloc..collections..btree..node..marker..LeafOrInternal$GT$$GT$15first_leaf_edge17hd6164a78f528b522E.llvm.12841644863924027351.exit", label %.lr.ph.i
 
@@ -476,6 +477,7 @@ define noundef nonnull align 8 dereferenceable(24) ptr @_ZN10serde_json3map5Entr
   %10 = icmp ult i64 %8, 11
   tail call void @llvm.assume(i1 %10)
   %11 = getelementptr inbounds nuw { [3 x i64] }, ptr %9, i64 %8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %11) ]
   br label %12
 
 12:                                               ; preds = %1, %4
diff --git a/bench/serde-rs-json/optimized/3o41byb1p1zh3720.ll b/bench/serde-rs-json/optimized/3o41byb1p1zh3720.ll
index 23188bc3bd7..20bfc78963c 100644
--- a/bench/serde-rs-json/optimized/3o41byb1p1zh3720.ll
+++ b/bench/serde-rs-json/optimized/3o41byb1p1zh3720.ll
@@ -352,9 +352,8 @@ define noundef align 8 dereferenceable_or_null(32) ptr @"_ZN73_$LT$alloc..string
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %3, ptr noundef nonnull align 8 dereferenceable(24) %20, i64 24, i1 false), !noalias !49
   %21 = call { ptr, ptr } @"_ZN5alloc11collections5btree4node173Handle$LT$alloc..collections..btree..node..NodeRef$LT$alloc..collections..btree..node..marker..Immut$C$K$C$V$C$NodeType$GT$$C$alloc..collections..btree..node..marker..KV$GT$7into_kv17ha248e88e5d7f0c6dE"(ptr noalias noundef nonnull align 8 captures(none) dereferenceable(24) %3), !noalias !46
   %.fca.1.extract.i.i = extractvalue { ptr, ptr } %21, 1
-  %22 = icmp ne ptr %.fca.1.extract.i.i, null
-  tail call void @llvm.assume(i1 %22)
-  br label %23
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.fca.1.extract.i.i) ]
+  br label %22
 
 23:                                               ; preds = %19, %15
   %.1.i.i = phi ptr [ %.fca.1.extract.i.i, %19 ], [ null, %15 ]
@@ -362,7 +361,7 @@ define noundef align 8 dereferenceable_or_null(32) ptr @"_ZN73_$LT$alloc..string
   br label %"_ZN5alloc11collections5btree3map25BTreeMap$LT$K$C$V$C$A$GT$3get17h6c60ddd5564b8f49E.exit.i"
 
 "_ZN5alloc11collections5btree3map25BTreeMap$LT$K$C$V$C$A$GT$3get17h6c60ddd5564b8f49E.exit.i": ; preds = %23, %11
-  %.0.i.i = phi ptr [ %.1.i.i, %23 ], [ null, %11 ]
+  %.0.i.i = phi ptr [ %.1.i.i, %22 ], [ null, %11 ]
   call void @llvm.lifetime.end.p0(ptr nonnull %3), !noalias !45
   br label %"_ZN55_$LT$str$u20$as$u20$serde_json..value..index..Index$GT$10index_into17h111be33034785bb5E.exit"
 
diff --git a/bench/smol-rs/optimized/2s1v940hwu43buna.ll b/bench/smol-rs/optimized/2s1v940hwu43buna.ll
index 425d6e5e6d0..97743790656 100644
--- a/bench/smol-rs/optimized/2s1v940hwu43buna.ll
+++ b/bench/smol-rs/optimized/2s1v940hwu43buna.ll
@@ -223,7 +223,7 @@ define hidden void @"_ZN16concurrent_queue7bounded16Bounded$LT$T$GT$3pop17h07238
 33:                                               ; preds = %26
   call void @llvm.lifetime.start.p0(ptr nonnull %3)
   store i64 0, ptr %3, align 8
-  call void asm sideeffect inteldialect "lock not qword ptr [${0:q}]", "r,~{memory}"(ptr nonnull %3) #10, !srcloc !7
+  call void asm sideeffect inteldialect "lock not qword ptr [${0:q}]", "r,~{memory}"(ptr nonnull %3) #11, !srcloc !7
   call void @llvm.lifetime.end.p0(ptr nonnull %3)
   %34 = load atomic i64, ptr %17 monotonic, align 128
   %35 = load i64, ptr %5, align 8, !noundef !4
@@ -359,7 +359,7 @@ define hidden { i64, ptr } @"_ZN16concurrent_queue7bounded16Bounded$LT$T$GT$4pus
 40:                                               ; preds = %30
   call void @llvm.lifetime.start.p0(ptr nonnull %3)
   store i64 0, ptr %3, align 8
-  call void asm sideeffect inteldialect "lock not qword ptr [${0:q}]", "r,~{memory}"(ptr nonnull %3) #10, !srcloc !7
+  call void asm sideeffect inteldialect "lock not qword ptr [${0:q}]", "r,~{memory}"(ptr nonnull %3) #11, !srcloc !7
   call void @llvm.lifetime.end.p0(ptr nonnull %3)
   %41 = load atomic i64, ptr %0 monotonic, align 128
   %42 = load i64, ptr %11, align 128, !noundef !4
@@ -443,12 +443,12 @@ define hidden void @"_ZN3std4sync6rwlock24RwLockReadGuard$LT$T$GT$3new17hbe8e28c
   %3 = getelementptr inbounds nuw i8, ptr %1, i64 8
   %4 = load atomic i8, ptr %3 monotonic, align 8
   %5 = icmp ne i8 %4, 0
+  %6 = getelementptr inbounds nuw i8, ptr %1, i64 16
   %spec.select.i = zext i1 %5 to i64
-  %.sink.i = getelementptr inbounds nuw i8, ptr %1, i64 16
-  %6 = getelementptr inbounds nuw i8, ptr %0, i64 8
-  store ptr %.sink.i, ptr %6, align 8, !alias.scope !10
-  %7 = getelementptr inbounds nuw i8, ptr %0, i64 16
-  store ptr %1, ptr %7, align 8, !alias.scope !10
+  %.sink.i = getelementptr inbounds nuw i8, ptr %0, i64 8
+  store ptr %6, ptr %7, align 8, !alias.scope !10
+  %8 = getelementptr inbounds nuw i8, ptr %0, i64 16
+  store ptr %1, ptr %8, align 8, !alias.scope !10
   store i64 %spec.select.i, ptr %0, align 8, !alias.scope !10
   ret void
 }
@@ -463,6 +463,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %.val = load ptr, ptr %7, align 8, !nonnull !4, !noundef !4
   %8 = getelementptr i8, ptr %6, i64 16
   %.val1 = load i64, ptr %8, align 8, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %5), !noalias !13
   call void @_ZN4core3fmt9Formatter10debug_list17h1616b9a56f5bf339E(ptr noalias noundef nonnull sret({ { ptr, i8, i8, [6 x i8] } }) align 8 captures(none) dereferenceable(16) %5, ptr noalias noundef nonnull align 8 dereferenceable(64) %1), !noalias !19
   %9 = getelementptr inbounds i8, ptr %.val, i64 %.val1
@@ -1019,6 +1020,9 @@ declare void @llvm.lifetime.start.p0(ptr captures(none)) #7
 ; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite)
 declare void @llvm.lifetime.end.p0(ptr captures(none)) #7
 
+; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #8
+
 ; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite)
 declare void @llvm.experimental.noalias.scope.decl(metadata) #8
 
@@ -1030,10 +1034,11 @@ attributes #4 = { cold noreturn nounwind nonlazybind uwtable "probe-stack"="inli
 attributes #5 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #6 = { cold nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #7 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
-attributes #8 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
-attributes #9 = { noreturn }
-attributes #10 = { nounwind }
-attributes #11 = { cold noreturn nounwind }
+attributes #8 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #9 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #10 = { noreturn }
+attributes #11 = { nounwind }
+attributes #12 = { cold noreturn nounwind }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/smol-rs/optimized/5836b0ge3mikiq0d.ll b/bench/smol-rs/optimized/5836b0ge3mikiq0d.ll
index de971cc8a6a..9e6997fe68b 100644
--- a/bench/smol-rs/optimized/5836b0ge3mikiq0d.ll
+++ b/bench/smol-rs/optimized/5836b0ge3mikiq0d.ll
@@ -74,6 +74,7 @@ define internal fastcc void @"_ZN4core3ptr127drop_in_place$LT$$LP$parking..Parke
   %.val = load ptr, ptr %8, align 8, !nonnull !17, !align !18, !noundef !17
   %9 = getelementptr inbounds nuw i8, ptr %0, i64 16
   %.val2 = load ptr, ptr %9, align 8, !noundef !17
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %10 = getelementptr inbounds nuw i8, ptr %.val, i64 24
   %11 = load ptr, ptr %10, align 8, !nonnull !17, !noundef !17
   invoke void %11(ptr noundef %.val2)
@@ -84,6 +85,7 @@ define internal fastcc void @"_ZN4core3ptr127drop_in_place$LT$$LP$parking..Parke
   %.val3 = load ptr, ptr %12, align 8, !nonnull !17, !align !18, !noundef !17
   %13 = getelementptr inbounds nuw i8, ptr %0, i64 16
   %.val4 = load ptr, ptr %13, align 8, !noundef !17
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3) ]
   %14 = getelementptr inbounds nuw i8, ptr %.val3, i64 24
   %15 = load ptr, ptr %14, align 8, !nonnull !17, !noundef !17
   invoke void %15(ptr noundef %.val4)
@@ -487,6 +489,7 @@ _ZN8async_io6driver8block_on5CACHE7__getit17h278e05a6d0505739E.exit.thread.i: ;
 83:                                               ; preds = %_ZN8async_io6driver8block_on5CACHE7__getit17h278e05a6d0505739E.exit.thread.i
   store i64 -1, ptr %.0.i.i6.i, align 8, !noalias !104
   %84 = getelementptr inbounds nuw i8, ptr %.0.i.i6.i, i64 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.0.i.i6.i) ]
   br label %86
 
 85:                                               ; preds = %_ZN8async_io6driver8block_on5CACHE7__getit17h278e05a6d0505739E.exit.thread.i
@@ -624,6 +627,7 @@ default.unreachable:                              ; preds = %.backedge.i.i
 
 131:                                              ; preds = %126
   %.val.i.i.i = load ptr, ptr %128, align 8, !noalias !107, !nonnull !17, !noundef !17
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i.i.i) ]
   %132 = getelementptr inbounds nuw i8, ptr %.val.i.i.i, i64 128
   invoke void @_ZN14async_executor6Runner3new17h7accacdf95488721E(ptr noalias noundef nonnull sret({ ptr, { ptr, { i64 } }, ptr, { i64 } }) align 8 captures(none) dereferenceable(40) %92, ptr noundef nonnull align 128 %132)
           to label %133 unwind label %129, !noalias !107
@@ -652,6 +656,7 @@ _ZN8fastrand10global_rng3RNG7__getit17h976a44bdba5e523cE.exit.i.i.i.i.i: ; preds
   %144 = lshr i128 %143, 64
   %145 = xor i128 %144, %143
   %146 = trunc i128 %145 to i64
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.0.i.i2.i.i.i.i.i) ]
   store i64 %139, ptr %.0.i.i2.i.i.i.i.i, align 8, !noalias !107
   br label %149
 
@@ -922,6 +927,7 @@ _ZN12tracing_core8callsite15DefaultCallsite8interest17h75ffbf7bbedb93daE.exit.i.
   %.val.i357.i.i = load ptr, ptr %226, align 8, !alias.scope !134, !noalias !104, !nonnull !17, !align !18, !noundef !17
   %227 = getelementptr inbounds nuw i8, ptr %42, i64 16
   %.val2.i.i.i = load ptr, ptr %227, align 8, !alias.scope !134, !noalias !104, !noundef !17
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i357.i.i) ]
   %228 = getelementptr inbounds nuw i8, ptr %.val.i357.i.i, i64 24
   %229 = load ptr, ptr %228, align 8, !noalias !104, !nonnull !17, !noundef !17
   invoke void %229(ptr noundef %.val2.i.i.i)
@@ -932,6 +938,7 @@ _ZN12tracing_core8callsite15DefaultCallsite8interest17h75ffbf7bbedb93daE.exit.i.
   %.val3.i.i.i = load ptr, ptr %230, align 8, !alias.scope !134, !noalias !104, !nonnull !17, !align !18, !noundef !17
   %231 = getelementptr inbounds nuw i8, ptr %42, i64 16
   %.val4.i.i.i = load ptr, ptr %231, align 8, !alias.scope !134, !noalias !104, !noundef !17
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3.i.i.i) ]
   %232 = getelementptr inbounds nuw i8, ptr %.val3.i.i.i, i64 24
   %233 = load ptr, ptr %232, align 8, !noalias !104, !nonnull !17, !noundef !17
   invoke void %233(ptr noundef %.val4.i.i.i)
@@ -1952,6 +1959,7 @@ _ZN3std4sync6poison4Flag4done17h5bffa24fa61aa5e0E.llvm.14408593437386099104.exit
 
 "_ZN4core3ptr254drop_in_place$LT$async_io..driver..CallOnDrop$LT$async_io..driver..block_on$LT$$LP$$RP$$C$async_executor..Executor..run$LT$$LP$$RP$$C$core..future..pending..Pending$LT$$LP$$RP$$GT$$GT$..$u7b$$u7b$closure$u7d$$u7d$$GT$..$u7b$$u7b$closure$u7d$$u7d$$GT$$GT$17h7e3b733b22200500E.exit": ; preds = %.noexc22, %534
   %.pn = phi { ptr, i32 } [ %535, %534 ], [ %eh.lpad-body, %.noexc22 ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %46) ]
   %530 = load i64, ptr %46, align 8, !range !52, !alias.scope !256, !noalias !259, !noundef !17
   %531 = icmp eq i64 %530, 2
   br i1 %531, label %"_ZN4core3ptr43drop_in_place$LT$tracing..span..Entered$GT$17h9d67df26919f87a1E.exit", label %532
@@ -1967,6 +1975,7 @@ _ZN3std4sync6poison4Flag4done17h5bffa24fa61aa5e0E.llvm.14408593437386099104.exit
   br label %"_ZN4core3ptr254drop_in_place$LT$async_io..driver..CallOnDrop$LT$async_io..driver..block_on$LT$$LP$$RP$$C$async_executor..Executor..run$LT$$LP$$RP$$C$core..future..pending..Pending$LT$$LP$$RP$$GT$$GT$..$u7b$$u7b$closure$u7d$$u7d$$GT$..$u7b$$u7b$closure$u7d$$u7d$$GT$$GT$17h7e3b733b22200500E.exit"
 
 "_ZN4core3ptr254drop_in_place$LT$async_io..driver..CallOnDrop$LT$async_io..driver..block_on$LT$$LP$$RP$$C$async_executor..Executor..run$LT$$LP$$RP$$C$core..future..pending..Pending$LT$$LP$$RP$$GT$$GT$..$u7b$$u7b$closure$u7d$$u7d$$GT$..$u7b$$u7b$closure$u7d$$u7d$$GT$$GT$17h7e3b733b22200500E.exit27": ; preds = %.noexc25
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %46) ]
   %536 = load i64, ptr %46, align 8, !range !52, !noundef !17
   %537 = icmp eq i64 %536, 2
   br i1 %537, label %"_ZN4core3ptr40drop_in_place$LT$tracing..span..Span$GT$17h69eb9e1cbda42f23E.exit", label %538
diff --git a/bench/softposit-rs/optimized/1jooigl29qhneyer.ll b/bench/softposit-rs/optimized/1jooigl29qhneyer.ll
index e12e1c4518c..5daaac2e200 100644
--- a/bench/softposit-rs/optimized/1jooigl29qhneyer.ll
+++ b/bench/softposit-rs/optimized/1jooigl29qhneyer.ll
@@ -1855,9 +1855,11 @@ _ZN4core3fmt9Formatter9write_fmt17h40252474da72b710E.exit: ; preds = %2, %7, %_Z
   %38 = getelementptr inbounds nuw i8, ptr %5, i64 8
   store ptr @"_ZN4core3fmt5float52_$LT$impl$u20$core..fmt..Display$u20$for$u20$f64$GT$3fmt17h2ea2ae54310fbdaeE", ptr %38, align 8
   %39 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %39, align 8, !nonnull !4, !noundef !4
+  %.val = load ptr, ptr %39, align 8
   %40 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val1 = load ptr, ptr %40, align 8, !nonnull !4, !noundef !4
+  %.val1 = load ptr, ptr %40, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !5
   store ptr @anon.5be969b161c3ca3248ac477383ae4705.7, ptr %3, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 8
@@ -1885,9 +1887,11 @@ _ZN4core3fmt9Arguments12as_const_str17h12e0cdd0f797b759E.exit.i:
   %4 = getelementptr inbounds nuw i8, ptr %3, i64 8
   store ptr @"_ZN4core3fmt3num3imp52_$LT$impl$u20$core..fmt..Display$u20$for$u20$i32$GT$3fmt17h299accfbede7160dE", ptr %4, align 8
   %5 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %5, align 8, !nonnull !4, !noundef !4
+  %.val = load ptr, ptr %5, align 8
   %6 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val1 = load ptr, ptr %6, align 8, !nonnull !4, !noundef !4
+  %.val1 = load ptr, ptr %6, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !8
   store ptr @anon.5be969b161c3ca3248ac477383ae4705.10, ptr %2, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
@@ -3737,6 +3741,9 @@ declare void @llvm.lifetime.start.p0(ptr captures(none)) #8
 ; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite)
 declare void @llvm.lifetime.end.p0(ptr captures(none)) #8
 
+; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #9
+
 ; Function Attrs: nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none)
 declare float @llvm.fabs.f32(float) #9
 
@@ -3776,9 +3783,10 @@ attributes #5 = { nofree norecurse nosync nounwind nonlazybind memory(argmem: re
 attributes #6 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #7 = { inlinehint nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #8 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
-attributes #9 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
-attributes #10 = { nocallback nofree nosync nounwind speculatable willreturn memory(none) }
-attributes #11 = { noreturn }
+attributes #9 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #10 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
+attributes #11 = { nocallback nofree nosync nounwind speculatable willreturn memory(none) }
+attributes #12 = { noreturn }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/softposit-rs/optimized/kf9u47qfx5x7qom.ll b/bench/softposit-rs/optimized/kf9u47qfx5x7qom.ll
index 8447db4f2b4..e0db5c5b437 100644
--- a/bench/softposit-rs/optimized/kf9u47qfx5x7qom.ll
+++ b/bench/softposit-rs/optimized/kf9u47qfx5x7qom.ll
@@ -563,9 +563,11 @@ _ZN4core3fmt9Formatter9write_fmt17h40252474da72b710E.exit: ; preds = %2, %7, %_Z
   %38 = getelementptr inbounds nuw i8, ptr %5, i64 8
   store ptr @"_ZN4core3fmt5float52_$LT$impl$u20$core..fmt..Display$u20$for$u20$f64$GT$3fmt17h2ea2ae54310fbdaeE", ptr %38, align 8
   %39 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %39, align 8, !nonnull !7, !noundef !7
+  %.val = load ptr, ptr %39, align 8
   %40 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val1 = load ptr, ptr %40, align 8, !nonnull !7, !noundef !7
+  %.val1 = load ptr, ptr %40, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !14
   store ptr @anon.4540a05e70eb433947f08bd653635aa8.5, ptr %3, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 8
@@ -607,6 +609,9 @@ declare void @llvm.lifetime.start.p0(ptr captures(none)) #6
 ; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite)
 declare void @llvm.lifetime.end.p0(ptr captures(none)) #6
 
+; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #7
+
 ; Function Attrs: nocallback nofree nounwind willreturn memory(argmem: write)
 declare void @llvm.memset.p0.i64(ptr writeonly captures(none), i8, i64, i1 immarg) #7
 
@@ -618,7 +623,8 @@ attributes #4 = { mustprogress nocallback nofree nounwind willreturn memory(argm
 attributes #5 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #6 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
 attributes #7 = { nocallback nofree nounwind willreturn memory(argmem: write) }
-attributes #8 = { noreturn }
+attributes #8 = { nocallback nofree nounwind willreturn memory(argmem: write) }
+attributes #9 = { noreturn }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/sqlite/optimized/sqlite3.ll b/bench/sqlite/optimized/sqlite3.ll
index ebd2352fb1f..1ce9bf1de15 100644
--- a/bench/sqlite/optimized/sqlite3.ll
+++ b/bench/sqlite/optimized/sqlite3.ll
@@ -59548,8 +59548,7 @@ define internal fastcc i32 @pagerWalFrames(ptr noundef captures(none) %0, ptr no
   br i1 %.not, label %.loopexit42, label %.preheader41
 
 .preheader41:                                     ; preds = %4
-  %.not3057 = icmp ne ptr %1, null
-  tail call void @llvm.assume(i1 %.not3057)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   br label %.lr.ph
 
 .lr.ph:                                           ; preds = %.preheader41, %.lr.ph
@@ -199257,9 +199256,8 @@ sqlite3VdbeAddOp2.exit:                           ; preds = %22, %20, %codeReal.
 }
 
 ; Function Attrs: nofree norecurse nosync nounwind memory(read, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable
-define internal fastcc range(i32 0, 2) i32 @sqlite3ExprTruthValue(ptr noundef readonly captures(address_is_null) %0) unnamed_addr #16 {
-  %.not9.i = icmp ne ptr %0, null
-  tail call void @llvm.assume(i1 %.not9.i)
+define internal fastcc range(i32 0, 2) i32 @sqlite3ExprTruthValue(ptr noundef readonly captures(none) %0) unnamed_addr #16 {
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   %2 = getelementptr inbounds nuw i8, ptr %0, i64 4
   %3 = load i32, ptr %2, align 4, !tbaa !291
   %4 = and i32 %3, 532480
@@ -203375,7 +203373,8 @@ define internal void @sqlite3ExprIfFalse(ptr noundef %0, ptr noundef %1, i32 nou
   %41 = load i8, ptr %40, align 2, !tbaa !2126
   %42 = icmp eq i8 %41, 46
   %43 = getelementptr inbounds nuw i8, ptr %1, i64 24
-  %44 = load ptr, ptr %43, align 8, !tbaa !905, !nonnull !851, !noundef !851
+  %44 = load ptr, ptr %43, align 8, !tbaa !905
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %44) ]
   %45 = getelementptr inbounds nuw i8, ptr %44, i64 4
   %46 = load i32, ptr %45, align 4, !tbaa !291
   %47 = and i32 %46, 532480
@@ -206196,6 +206195,7 @@ thread-pre-split:                                 ; preds = %15
   ]
 
 62:                                               ; preds = %58
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %60) ]
   %63 = getelementptr inbounds nuw i8, ptr %60, i64 4
   %64 = load i32, ptr %63, align 4, !tbaa !291
   %65 = and i32 %64, 532480
@@ -212302,7 +212302,8 @@ define internal void @sqlite3ExprIfTrue(ptr noundef %0, ptr noundef %1, i32 noun
   %38 = load i8, ptr %37, align 2, !tbaa !2126
   %39 = icmp eq i8 %38, 46
   %40 = getelementptr inbounds nuw i8, ptr %1, i64 24
-  %41 = load ptr, ptr %40, align 8, !tbaa !905, !nonnull !851, !noundef !851
+  %41 = load ptr, ptr %40, align 8, !tbaa !905
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %41) ]
   %42 = getelementptr inbounds nuw i8, ptr %41, i64 4
   %43 = load i32, ptr %42, align 4, !tbaa !291
   %44 = and i32 %43, 532480
@@ -268989,8 +268990,8 @@ define internal fastcc i32 @whereLoopAddVirtual(ptr noundef nonnull captures(non
   %22 = load ptr, ptr %21, align 8, !tbaa !2793
   %23 = getelementptr inbounds nuw i8, ptr %20, i64 16
   %24 = load ptr, ptr %23, align 8, !tbaa !1926
-  %.not268.i = icmp ne ptr %11, null
-  br i1 %.not268.i, label %.lr.ph272.i, label %._crit_edge273.i
+  %.not268.i = icmp eq ptr %11, null
+  br i1 %.not268.i, label %._crit_edge273.i, label %.lr.ph272.i
 
 .lr.ph272.i:                                      ; preds = %3
   %25 = getelementptr inbounds nuw i8, ptr %20, i64 28
@@ -269398,7 +269399,7 @@ sqlite3PrimaryKeyIndex.exit.i:                    ; preds = %.lr.ph.i.i
   store i32 %.0186.i, ptr %202, align 8, !tbaa !909
   %203 = getelementptr inbounds nuw i8, ptr %.0.i.i216.i, i64 116
   store i32 0, ptr %203, align 4, !tbaa !907
-  br i1 %.not268.i, label %.lr.ph309.i, label %._crit_edge310.i
+  br i1 %.not268.i, label %._crit_edge310.i, label %.lr.ph309.i
 
 .lr.ph309.i:                                      ; preds = %.loopexit.i, %._crit_edge299.i
   %204 = phi i32 [ %282, %._crit_edge299.i ], [ 0, %.loopexit.i ]
@@ -269745,7 +269746,7 @@ whereLoopResize.exit:                             ; preds = %318
 
 .lr.ph150:                                        ; preds = %.preheader
   %360 = load ptr, ptr %175, align 8, !tbaa !891
-  call void @llvm.assume(i1 %.not268.i)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %11) ]
   %361 = load i32, ptr %359, align 4, !tbaa !896
   br label %362
 
@@ -271494,8 +271495,7 @@ define internal fastcc i32 @whereLoopAddVirtualOne(ptr noundef nonnull captures(
 
 .lr.ph244:                                        ; preds = %8
   %26 = load ptr, ptr %24, align 8, !tbaa !3137
-  %.not14.i = icmp ne ptr %10, null
-  tail call void @llvm.assume(i1 %.not14.i)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %10) ]
   %27 = getelementptr inbounds nuw i8, ptr %10, i64 20
   %28 = load i32, ptr %27, align 4, !tbaa !896
   %.not165 = icmp eq ptr %7, null
@@ -321748,8 +321748,7 @@ sqlite3_aggregate_context.exit:                   ; preds = %17, %19
   br i1 %28, label %167, label %58
 
 58:                                               ; preds = %55
-  %.not.i.i = icmp ne ptr %57, null
-  tail call void @llvm.assume(i1 %.not.i.i)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %57) ]
   %59 = getelementptr inbounds nuw i8, ptr %57, i64 20
   %60 = load i16, ptr %59, align 4, !tbaa !147
   %61 = and i16 %60, 514
@@ -426740,8 +426739,7 @@ sqlite3_value_bytes.exit:                         ; preds = %25, %30, %34, %37,
   br label %jsonConvertTextToBlob.exit.thread
 
 44:                                               ; preds = %8
-  %.not.i.i106 = icmp ne ptr %16, null
-  tail call void @llvm.assume(i1 %.not.i.i106)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %16) ]
   %45 = getelementptr inbounds nuw i8, ptr %16, i64 20
   %46 = load i16, ptr %45, align 4, !tbaa !147
   %47 = and i16 %46, 514
diff --git a/bench/stat-rs/optimized/4d9pj14shc9lbmph.ll b/bench/stat-rs/optimized/4d9pj14shc9lbmph.ll
index 6a10a56dda3..12afd491b2c 100644
--- a/bench/stat-rs/optimized/4d9pj14shc9lbmph.ll
+++ b/bench/stat-rs/optimized/4d9pj14shc9lbmph.ll
@@ -152,9 +152,11 @@ _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i:
   %.sroa.46.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 24
   store ptr @"_ZN4core3fmt5float52_$LT$impl$u20$core..fmt..Display$u20$for$u20$f64$GT$3fmt17hf1cee52ef4fcaed8E", ptr %.sroa.46.0..sroa_idx, align 8
   %6 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %6, align 8, !nonnull !5, !noundef !5
+  %.val = load ptr, ptr %6, align 8
   %7 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val7 = load ptr, ptr %7, align 8, !nonnull !5, !noundef !5
+  %.val7 = load ptr, ptr %7, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val7) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !6
   store ptr @anon.add817559d7beeee5c0788ec3c34287f.17, ptr %2, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
@@ -311,9 +313,11 @@ _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i:
   %.sroa.46.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 24
   store ptr @"_ZN4core3fmt5float52_$LT$impl$u20$core..fmt..Display$u20$for$u20$f64$GT$3fmt17hf1cee52ef4fcaed8E", ptr %.sroa.46.0..sroa_idx, align 8
   %6 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %6, align 8, !nonnull !5, !noundef !5
+  %.val = load ptr, ptr %6, align 8
   %7 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val7 = load ptr, ptr %7, align 8, !nonnull !5, !noundef !5
+  %.val7 = load ptr, ptr %7, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val7) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !9
   store ptr @anon.add817559d7beeee5c0788ec3c34287f.20, ptr %2, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
@@ -360,7 +364,7 @@ define noundef double @"_ZN126_$LT$statrs..distribution..fisher_snedecor..Fisher
 19:                                               ; preds = %8
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !17
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %3, ptr noundef nonnull align 8 dereferenceable(40) %4, i64 40, i1 false), !noalias !15
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #15, !noalias !12
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #16, !noalias !12
   unreachable
 
 _ZN6statrs8function4beta8beta_reg17hba0ea301559e3806E.exit: ; preds = %8
@@ -405,7 +409,7 @@ define noundef double @"_ZN126_$LT$statrs..distribution..fisher_snedecor..Fisher
 20:                                               ; preds = %8
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !23
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %3, ptr noundef nonnull align 8 dereferenceable(40) %4, i64 40, i1 false), !noalias !21
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #15, !noalias !18
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #16, !noalias !18
   unreachable
 
 _ZN6statrs8function4beta8beta_reg17hba0ea301559e3806E.exit: ; preds = %8
@@ -565,7 +569,7 @@ define noundef double @"_ZN123_$LT$statrs..distribution..fisher_snedecor..Fisher
   store i64 %.sroa.6.0.ph.i, ptr %.sroa.6.0..sroa_idx.i, align 8, !noalias !28
   %.sroa.9.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %3, i64 16
   store i64 1, ptr %.sroa.9.0..sroa_idx.i, align 8, !noalias !28
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.42.llvm.10715550030521876899) #15, !noalias !29
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.42.llvm.10715550030521876899) #16, !noalias !29
   unreachable
 
 _ZN6statrs8function4beta4beta17h85c22bb6a61a7ba5E.exit: ; preds = %20
@@ -626,9 +630,11 @@ _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i:
   %.sroa.42.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 8
   store ptr @"_ZN4core3fmt5float52_$LT$impl$u20$core..fmt..Display$u20$for$u20$f64$GT$3fmt17hf1cee52ef4fcaed8E", ptr %.sroa.42.0..sroa_idx, align 8
   %4 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %4, align 8, !nonnull !5, !noundef !5
+  %.val = load ptr, ptr %4, align 8
   %5 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val3 = load ptr, ptr %5, align 8, !nonnull !5, !noundef !5
+  %.val3 = load ptr, ptr %5, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !35
   store ptr @anon.add817559d7beeee5c0788ec3c34287f.22, ptr %2, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
@@ -922,9 +928,11 @@ _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i:
   %.sroa.46.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 24
   store ptr @"_ZN4core3fmt5float52_$LT$impl$u20$core..fmt..Display$u20$for$u20$f64$GT$3fmt17hf1cee52ef4fcaed8E", ptr %.sroa.46.0..sroa_idx, align 8
   %6 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %6, align 8, !nonnull !5, !noundef !5
+  %.val = load ptr, ptr %6, align 8
   %7 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val7 = load ptr, ptr %7, align 8, !nonnull !5, !noundef !5
+  %.val7 = load ptr, ptr %7, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val7) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !38
   store ptr @anon.add817559d7beeee5c0788ec3c34287f.28, ptr %2, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
@@ -960,7 +968,7 @@ define noundef double @"_ZN128_$LT$statrs..distribution..negative_binomial..Nega
 12:                                               ; preds = %2
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !46
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %3, ptr noundef nonnull align 8 dereferenceable(40) %4, i64 40, i1 false), !noalias !44
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #15, !noalias !41
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #16, !noalias !41
   unreachable
 
 _ZN6statrs8function4beta8beta_reg17hba0ea301559e3806E.exit: ; preds = %2
@@ -990,7 +998,7 @@ define noundef double @"_ZN128_$LT$statrs..distribution..negative_binomial..Nega
 13:                                               ; preds = %2
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !52
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %3, ptr noundef nonnull align 8 dereferenceable(40) %4, i64 40, i1 false), !noalias !50
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #15, !noalias !47
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #16, !noalias !47
   unreachable
 
 _ZN6statrs8function4beta8beta_reg17hba0ea301559e3806E.exit: ; preds = %2
@@ -1255,7 +1263,7 @@ define noundef double @_ZN6statrs8function4beta7ln_beta17h82d301b62336438bE(doub
   store i64 %.sroa.7.0.ph, ptr %.sroa.7.0..sroa_idx, align 8, !noalias !61
   %.sroa.11.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 16
   store i64 1, ptr %.sroa.11.0..sroa_idx, align 8, !noalias !61
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.39.llvm.10715550030521876899) #15, !noalias !62
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.39.llvm.10715550030521876899) #16, !noalias !62
   unreachable
 
 "_ZN4core6result19Result$LT$T$C$E$GT$6unwrap17hc4e55484334486acE.llvm.10715550030521876899.exit": ; preds = %5
@@ -1327,7 +1335,7 @@ define noundef double @_ZN6statrs8function4beta4beta17h85c22bb6a61a7ba5E(double
   store i64 %.sroa.6.0.ph, ptr %.sroa.6.0..sroa_idx, align 8, !noalias !70
   %.sroa.9.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 16
   store i64 1, ptr %.sroa.9.0..sroa_idx, align 8, !noalias !70
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.42.llvm.10715550030521876899) #15, !noalias !71
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.42.llvm.10715550030521876899) #16, !noalias !71
   unreachable
 
 "_ZN4core6result19Result$LT$T$C$E$GT$6unwrap17hc4e55484334486acE.llvm.10715550030521876899.exit": ; preds = %5
@@ -1419,7 +1427,7 @@ define noundef double @_ZN6statrs8function4beta8beta_inc17hdb112917ca1b2d54E(dou
   store i64 %.sroa.10.0.ph, ptr %.sroa.10.0..sroa_idx, align 8, !noalias !87
   %.sroa.11.0..sroa_idx = getelementptr inbounds nuw i8, ptr %5, i64 24
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(16) %.sroa.11.0..sroa_idx, ptr noundef nonnull align 8 dereferenceable(16) %.sroa.11, i64 16, i1 false), !noalias !87
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %5, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.43) #15, !noalias !88
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %5, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.43) #16, !noalias !88
   unreachable
 
 "_ZN4core6result19Result$LT$T$C$E$GT$6unwrap17hc4e55484334486acE.llvm.10715550030521876899.exit": ; preds = %12
@@ -1502,7 +1510,7 @@ define noundef double @_ZN6statrs8function4beta8beta_reg17hba0ea301559e3806E(dou
 8:                                                ; preds = %3
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !109
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %4, ptr noundef nonnull align 8 dereferenceable(40) %5, i64 40, i1 false), !noalias !107
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %4, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #15, !noalias !104
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %4, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #16, !noalias !104
   unreachable
 
 "_ZN4core6result19Result$LT$T$C$E$GT$6unwrap17hc4e55484334486acE.llvm.10715550030521876899.exit": ; preds = %3
@@ -1723,7 +1731,7 @@ define noundef double @_ZN6statrs8function4beta12inv_beta_reg17h6cd70450337c051a
   store i64 %.sroa.7.0.ph.i, ptr %.sroa.7.0..sroa_idx.i, align 8, !noalias !114
   %.sroa.11.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %6, i64 16
   store i64 1, ptr %.sroa.11.0..sroa_idx.i, align 8, !noalias !114
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %6, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.39.llvm.10715550030521876899) #15, !noalias !115
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %6, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.39.llvm.10715550030521876899) #16, !noalias !115
   unreachable
 
 _ZN6statrs8function4beta7ln_beta17h82d301b62336438bE.exit: ; preds = %8
@@ -1875,7 +1883,7 @@ _ZN6statrs8function4beta7ln_beta17h82d301b62336438bE.exit: ; preds = %8
 119:                                              ; preds = %116
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !124
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %4, ptr noundef nonnull align 8 dereferenceable(40) %5, i64 40, i1 false), !noalias !122
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %4, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #15, !noalias !119
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %4, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #16, !noalias !119
   unreachable
 
 _ZN6statrs8function4beta8beta_reg17hba0ea301559e3806E.exit: ; preds = %116
@@ -1991,7 +1999,7 @@ define noundef double @_ZN6statrs8function8logistic5logit17hac7411a972977cb7E(do
   store ptr @anon.add817559d7beeee5c0788ec3c34287f.49, ptr %.sroa.8.0..sroa_idx, align 8, !noalias !129
   %.sroa.9.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 32
   store i64 1, ptr %.sroa.9.0..sroa_idx, align 8, !noalias !129
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %2, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.48) #15, !noalias !130
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %2, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.48) #16, !noalias !130
   unreachable
 
 "_ZN4core6result19Result$LT$T$C$E$GT$6unwrap17hc4e55484334486acE.llvm.10715550030521876899.exit": ; preds = %1
@@ -2271,6 +2279,9 @@ declare double @llvm.fabs.f64(double) #8
 ; Function Attrs: mustprogress nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none)
 declare double @llvm.copysign.f64(double, double) #8
 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #9
+
 ; Function Attrs: nonlazybind uwtable
 declare noundef zeroext i1 @"_ZN4core3fmt5float50_$LT$impl$u20$core..fmt..Debug$u20$for$u20$f64$GT$3fmt17hfc20ca8ee8067926E"(ptr noalias noundef readonly align 8 dereferenceable(8), ptr noalias noundef align 8 dereferenceable(64)) unnamed_addr #4
 
@@ -2367,13 +2378,14 @@ attributes #5 = { mustprogress nofree norecurse nounwind nonlazybind willreturn
 attributes #6 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #7 = { inlinehint nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #8 = { mustprogress nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
-attributes #9 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
-attributes #10 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #11 = { mustprogress nocallback nofree nounwind nonlazybind willreturn memory(errnomem: write) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #12 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
-attributes #13 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
-attributes #14 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
-attributes #15 = { noreturn }
+attributes #9 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: write) }
+attributes #10 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
+attributes #11 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #12 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: write) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #13 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
+attributes #14 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
+attributes #15 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #16 = { noreturn }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/stat-rs/optimized/rkxxfn3f5mhspne.ll b/bench/stat-rs/optimized/rkxxfn3f5mhspne.ll
index bbfb1b4a708..fa01376f364 100644
--- a/bench/stat-rs/optimized/rkxxfn3f5mhspne.ll
+++ b/bench/stat-rs/optimized/rkxxfn3f5mhspne.ll
@@ -285,9 +285,11 @@ _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i:
   %.sroa.46.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 24
   store ptr @"_ZN4core3fmt5float52_$LT$impl$u20$core..fmt..Display$u20$for$u20$f64$GT$3fmt17hf1cee52ef4fcaed8E", ptr %.sroa.46.0..sroa_idx, align 8
   %6 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %6, align 8, !nonnull !4, !noundef !4
+  %.val = load ptr, ptr %6, align 8
   %7 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val7 = load ptr, ptr %7, align 8, !nonnull !4, !noundef !4
+  %.val7 = load ptr, ptr %7, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val7) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !33
   store ptr @anon.26f4206a9fc8a8c6d289e2be3cec11c9.4, ptr %2, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
@@ -374,7 +376,7 @@ define noundef double @"_ZN105_$LT$statrs..distribution..beta..Beta$u20$as$u20$s
 36:                                               ; preds = %"_ZN47_$LT$f64$u20$as$u20$approx..ulps_eq..UlpsEq$GT$7ulps_eq17hdd68b037342b848bE.llvm.13986783010576937582.exit.thread4"
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !42
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %3, ptr noundef nonnull align 8 dereferenceable(40) %4, i64 40, i1 false), !noalias !40
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #17, !noalias !36
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #18, !noalias !36
   unreachable
 
 _ZN6statrs8function4beta8beta_reg17hba0ea301559e3806E.exit: ; preds = %"_ZN47_$LT$f64$u20$as$u20$approx..ulps_eq..UlpsEq$GT$7ulps_eq17hdd68b037342b848bE.llvm.13986783010576937582.exit.thread4"
@@ -459,7 +461,7 @@ define noundef double @"_ZN105_$LT$statrs..distribution..beta..Beta$u20$as$u20$s
 37:                                               ; preds = %"_ZN47_$LT$f64$u20$as$u20$approx..ulps_eq..UlpsEq$GT$7ulps_eq17hdd68b037342b848bE.llvm.13986783010576937582.exit.thread4"
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !48
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %3, ptr noundef nonnull align 8 dereferenceable(40) %4, i64 40, i1 false), !noalias !46
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #17, !noalias !43
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #18, !noalias !43
   unreachable
 
 _ZN6statrs8function4beta8beta_reg17hba0ea301559e3806E.exit: ; preds = %"_ZN47_$LT$f64$u20$as$u20$approx..ulps_eq..UlpsEq$GT$7ulps_eq17hdd68b037342b848bE.llvm.13986783010576937582.exit.thread4"
@@ -561,7 +563,7 @@ define { i64, double } @"_ZN104_$LT$statrs..distribution..beta..Beta$u20$as$u20$
   store i64 %.sroa.7.0.ph.i, ptr %.sroa.7.0..sroa_idx.i, align 8, !noalias !53
   %.sroa.11.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %2, i64 16
   store i64 1, ptr %.sroa.11.0..sroa_idx.i, align 8, !noalias !53
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %2, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.39.llvm.10715550030521876899) #17, !noalias !54
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %2, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.39.llvm.10715550030521876899) #18, !noalias !54
   unreachable
 
 _ZN6statrs8function4beta7ln_beta17h82d301b62336438bE.exit: ; preds = %13
@@ -1091,9 +1093,11 @@ _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i:
   %.sroa.46.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 24
   store ptr @"_ZN4core3fmt3num3imp52_$LT$impl$u20$core..fmt..Display$u20$for$u20$u64$GT$3fmt17h5386a9d5c884cdb0E", ptr %.sroa.46.0..sroa_idx, align 8
   %6 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %6, align 8, !nonnull !4, !noundef !4
+  %.val = load ptr, ptr %6, align 8
   %7 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val7 = load ptr, ptr %7, align 8, !nonnull !4, !noundef !4
+  %.val7 = load ptr, ptr %7, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val7) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !58
   store ptr @anon.26f4206a9fc8a8c6d289e2be3cec11c9.11, ptr %2, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
@@ -1136,7 +1140,7 @@ define noundef double @"_ZN111_$LT$statrs..distribution..binomial..Binomial$u20$
 16:                                               ; preds = %7
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !66
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %3, ptr noundef nonnull align 8 dereferenceable(40) %4, i64 40, i1 false), !noalias !64
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #17, !noalias !61
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #18, !noalias !61
   unreachable
 
 _ZN6statrs8function4beta8beta_reg17hba0ea301559e3806E.exit: ; preds = %7
@@ -1175,7 +1179,7 @@ define noundef double @"_ZN111_$LT$statrs..distribution..binomial..Binomial$u20$
 15:                                               ; preds = %7
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !72
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %3, ptr noundef nonnull align 8 dereferenceable(40) %4, i64 40, i1 false), !noalias !70
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #17, !noalias !67
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.add817559d7beeee5c0788ec3c34287f.12.llvm.10715550030521876899, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.13.llvm.10715550030521876899, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.add817559d7beeee5c0788ec3c34287f.44.llvm.10715550030521876899) #18, !noalias !67
   unreachable
 
 _ZN6statrs8function4beta8beta_reg17hba0ea301559e3806E.exit: ; preds = %7
@@ -1675,9 +1679,11 @@ _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i:
   %.sroa.42.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 8
   store ptr @"_ZN4core3fmt5float52_$LT$impl$u20$core..fmt..Display$u20$for$u20$f64$GT$3fmt17hf1cee52ef4fcaed8E", ptr %.sroa.42.0..sroa_idx, align 8
   %5 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %5, align 8, !nonnull !4, !noundef !4
+  %.val = load ptr, ptr %5, align 8
   %6 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val3 = load ptr, ptr %6, align 8, !nonnull !4, !noundef !4
+  %.val3 = load ptr, ptr %6, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !150
   store ptr @anon.26f4206a9fc8a8c6d289e2be3cec11c9.13, ptr %2, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
@@ -1904,9 +1910,11 @@ _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i:
   %.sroa.42.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 8
   store ptr @"_ZN4core3fmt5float52_$LT$impl$u20$core..fmt..Display$u20$for$u20$f64$GT$3fmt17hf1cee52ef4fcaed8E", ptr %.sroa.42.0..sroa_idx, align 8
   %4 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %4, align 8, !nonnull !4, !noundef !4
+  %.val = load ptr, ptr %4, align 8
   %5 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val3 = load ptr, ptr %5, align 8, !nonnull !4, !noundef !4
+  %.val3 = load ptr, ptr %5, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !176
   store ptr @anon.26f4206a9fc8a8c6d289e2be3cec11c9.15, ptr %2, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
@@ -1940,7 +1948,7 @@ define noundef double @"_ZN109_$LT$statrs..distribution..poisson..Poisson$u20$as
 10:                                               ; preds = %2
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !184
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %3, ptr noundef nonnull align 8 dereferenceable(40) %4, i64 40, i1 false), !noalias !182
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.c1bf2e375591bb6a447bdf89942637bc.4.llvm.11173233603740741911, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.c1bf2e375591bb6a447bdf89942637bc.5.llvm.11173233603740741911, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.c1bf2e375591bb6a447bdf89942637bc.10.llvm.11173233603740741911) #17, !noalias !179
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.c1bf2e375591bb6a447bdf89942637bc.4.llvm.11173233603740741911, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.c1bf2e375591bb6a447bdf89942637bc.5.llvm.11173233603740741911, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.c1bf2e375591bb6a447bdf89942637bc.10.llvm.11173233603740741911) #18, !noalias !179
   unreachable
 
 _ZN6statrs8function5gamma8gamma_ur17h0b4d3ff45eccbdceE.exit: ; preds = %2
@@ -1967,7 +1975,7 @@ define noundef double @"_ZN109_$LT$statrs..distribution..poisson..Poisson$u20$as
 10:                                               ; preds = %2
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !190
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(40) %3, ptr noundef nonnull align 8 dereferenceable(40) %4, i64 40, i1 false), !noalias !188
-  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.c1bf2e375591bb6a447bdf89942637bc.4.llvm.11173233603740741911, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.c1bf2e375591bb6a447bdf89942637bc.5.llvm.11173233603740741911, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.c1bf2e375591bb6a447bdf89942637bc.14.llvm.11173233603740741911) #17, !noalias !185
+  call void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1 @anon.c1bf2e375591bb6a447bdf89942637bc.4.llvm.11173233603740741911, i64 noundef 43, ptr noundef nonnull align 1 %3, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.c1bf2e375591bb6a447bdf89942637bc.5.llvm.11173233603740741911, ptr noalias noundef readonly align 8 dereferenceable(24) @anon.c1bf2e375591bb6a447bdf89942637bc.14.llvm.11173233603740741911) #18, !noalias !185
   unreachable
 
 _ZN6statrs8function5gamma8gamma_lr17hde27b862f6dd8958E.exit: ; preds = %2
@@ -2179,9 +2187,11 @@ _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i:
   %.sroa.410.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 40
   store ptr @"_ZN4core3fmt5float52_$LT$impl$u20$core..fmt..Display$u20$for$u20$f64$GT$3fmt17hf1cee52ef4fcaed8E", ptr %.sroa.410.0..sroa_idx, align 8
   %8 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %8, align 8, !nonnull !4, !noundef !4
+  %.val = load ptr, ptr %8, align 8
   %9 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val11 = load ptr, ptr %9, align 8, !nonnull !4, !noundef !4
+  %.val11 = load ptr, ptr %9, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val11) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !213
   store ptr @anon.26f4206a9fc8a8c6d289e2be3cec11c9.18, ptr %2, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
@@ -2593,9 +2603,11 @@ _ZN4core3fmt9Arguments23as_statically_known_str17hd4a07815937ed51bE.exit.i:
   %.sroa.46.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 24
   store ptr @"_ZN4core3fmt5float52_$LT$impl$u20$core..fmt..Display$u20$for$u20$f64$GT$3fmt17hf1cee52ef4fcaed8E", ptr %.sroa.46.0..sroa_idx, align 8
   %6 = getelementptr inbounds nuw i8, ptr %1, i64 32
-  %.val = load ptr, ptr %6, align 8, !nonnull !4, !noundef !4
+  %.val = load ptr, ptr %6, align 8
   %7 = getelementptr inbounds nuw i8, ptr %1, i64 40
-  %.val7 = load ptr, ptr %7, align 8, !nonnull !4, !noundef !4
+  %.val7 = load ptr, ptr %7, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val7) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %2), !noalias !219
   store ptr @anon.26f4206a9fc8a8c6d289e2be3cec11c9.24, ptr %2, align 8
   %.sroa.5.0..sroa_idx = getelementptr inbounds nuw i8, ptr %2, i64 8
@@ -2933,6 +2945,9 @@ declare noundef double @"_ZN107_$LT$statrs..distribution..gamma..Gamma$u20$as$u2
 ; Function Attrs: nonlazybind uwtable
 declare noundef double @"_ZN104_$LT$statrs..distribution..gamma..Gamma$u20$as$u20$statrs..distribution..Continuous$LT$f64$C$f64$GT$$GT$3pdf17h1673f1a8c3c39778E"(ptr noalias noundef readonly align 8 dereferenceable(16), double noundef) unnamed_addr #8
 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #14
+
 ; Function Attrs: cold noreturn nonlazybind uwtable
 declare void @_ZN4core6result13unwrap_failed17h82b551e0ff2b2176E(ptr noalias noundef nonnull readonly align 1, i64 noundef, ptr noundef nonnull align 1, ptr noalias noundef readonly align 8 dereferenceable(24), ptr noalias noundef readonly align 8 dereferenceable(24)) unnamed_addr #13
 
@@ -2971,10 +2986,11 @@ attributes #10 = { nofree norecurse nosync nounwind nonlazybind memory(none) uwt
 attributes #11 = { mustprogress nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
 attributes #12 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
 attributes #13 = { cold noreturn nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
-attributes #14 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
-attributes #15 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
-attributes #16 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
-attributes #17 = { noreturn }
+attributes #14 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: write) }
+attributes #15 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
+attributes #16 = { nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
+attributes #17 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #18 = { noreturn }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/sundials/optimized/arkode_splittingstep_coefficients.ll b/bench/sundials/optimized/arkode_splittingstep_coefficients.ll
index 786f94ae62b..1251c471baf 100644
--- a/bench/sundials/optimized/arkode_splittingstep_coefficients.ll
+++ b/bench/sundials/optimized/arkode_splittingstep_coefficients.ll
@@ -52,14 +52,13 @@ define noalias noundef ptr @SplittingStepCoefficients_Alloc(i32 noundef %0, i32
   %15 = zext nneg i32 %0 to i64
   %16 = tail call noalias ptr @calloc(i64 noundef %15, i64 noundef 8) #15
   store ptr %16, ptr %8, align 8, !tbaa !14
-  %17 = icmp ne ptr %16, null
-  tail call void @llvm.assume(i1 %17)
-  %18 = shl nuw nsw i64 %15, 3
-  %19 = tail call noalias ptr @malloc(i64 noundef %18) #14
-  %20 = getelementptr inbounds nuw i8, ptr %8, i64 8
-  store ptr %19, ptr %20, align 8, !tbaa !15
-  %21 = icmp eq ptr %19, null
-  br i1 %21, label %.loopexit.sink.split, label %.lr.ph.preheader
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %16) ]
+  %17 = shl nuw nsw i64 %15, 3
+  %18 = tail call noalias ptr @malloc(i64 noundef %17) #14
+  %19 = getelementptr inbounds nuw i8, ptr %8, i64 8
+  store ptr %18, ptr %19, align 8, !tbaa !15
+  %20 = icmp eq ptr %18, null
+  br i1 %20, label %.loopexit.sink.split, label %.lr.ph.preheader
 
 .lr.ph.preheader:                                 ; preds = %10
   %22 = add nuw nsw i32 %1, 1
@@ -67,9 +66,8 @@ define noalias noundef ptr @SplittingStepCoefficients_Alloc(i32 noundef %0, i32
   %24 = zext nneg i32 %23 to i64
   %25 = shl nuw nsw i64 %24, 3
   %26 = tail call noalias ptr @malloc(i64 noundef %25) #14
-  %27 = icmp ne ptr %26, null
-  tail call void @llvm.assume(i1 %27)
-  %28 = zext nneg i32 %22 to i64
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %26) ]
+  %26 = zext nneg i32 %21 to i64
   br label %.lr.ph
 
 ._crit_edge:                                      ; preds = %.lr.ph
@@ -88,9 +86,9 @@ define noalias noundef ptr @SplittingStepCoefficients_Alloc(i32 noundef %0, i32
 
 .lr.ph:                                           ; preds = %.lr.ph.preheader, %.lr.ph
   %indvars.iv = phi i64 [ 0, %.lr.ph.preheader ], [ %indvars.iv.next, %.lr.ph ]
-  %36 = mul nuw nsw i64 %indvars.iv, %28
+  %36 = mul nuw nsw i64 %indvars.iv, %26
   %37 = getelementptr inbounds nuw ptr, ptr %26, i64 %36
-  %38 = getelementptr inbounds nuw ptr, ptr %19, i64 %indvars.iv
+  %38 = getelementptr inbounds nuw ptr, ptr %18, i64 %indvars.iv
   store ptr %37, ptr %38, align 8, !tbaa !16
   %indvars.iv.next = add nuw nsw i64 %indvars.iv, 1
   %exitcond.not = icmp eq i64 %indvars.iv.next, %15
@@ -98,7 +96,7 @@ define noalias noundef ptr @SplittingStepCoefficients_Alloc(i32 noundef %0, i32
 
 39:                                               ; preds = %._crit_edge
   tail call void @free(ptr noundef nonnull %16) #16
-  %40 = load ptr, ptr %19, align 8, !tbaa !16
+  %40 = load ptr, ptr %18, align 8, !tbaa !16
   %.not19.i65 = icmp eq ptr %40, null
   br i1 %.not19.i65, label %.loopexit.sink.split, label %41
 
@@ -109,18 +107,18 @@ define noalias noundef ptr @SplittingStepCoefficients_Alloc(i32 noundef %0, i32
 
 43:                                               ; preds = %41
   tail call void @free(ptr noundef nonnull %42) #16
-  %.pre21.i68 = load ptr, ptr %19, align 8, !tbaa !16
+  %.pre21.i68 = load ptr, ptr %18, align 8, !tbaa !16
   br label %44
 
 44:                                               ; preds = %43, %41
-  %45 = phi ptr [ %.pre21.i68, %43 ], [ %40, %41 ]
+  %45 = phi ptr [ %.pre21.i68, %41 ], [ %40, %39 ]
   tail call void @free(ptr noundef %45) #16
   br label %.loopexit.sink.split
 
 .preheader:                                       ; preds = %.preheader.preheader, %._crit_edge86
   %indvars.iv95 = phi i64 [ 0, %.preheader.preheader ], [ %indvars.iv.next96, %._crit_edge86 ]
   %46 = mul nuw nsw i64 %indvars.iv95, %35
-  %47 = getelementptr inbounds nuw ptr, ptr %19, i64 %indvars.iv95
+  %47 = getelementptr inbounds nuw ptr, ptr %18, i64 %indvars.iv95
   %48 = load ptr, ptr %47, align 8, !tbaa !16
   br label %49
 
@@ -130,7 +128,7 @@ define noalias noundef ptr @SplittingStepCoefficients_Alloc(i32 noundef %0, i32
   br i1 %exitcond99.not, label %.loopexit, label %.preheader
 
 49:                                               ; preds = %.preheader, %49
-  %indvars.iv90 = phi i64 [ 0, %.preheader ], [ %indvars.iv.next91, %49 ]
+  %indvars.iv90 = phi i64 [ 0, %.preheader ], [ %indvars.iv.next91, %47 ]
   %50 = add nuw nsw i64 %indvars.iv90, %46
   %51 = mul nuw nsw i64 %50, %33
   %52 = getelementptr inbounds nuw double, ptr %31, i64 %51
@@ -141,7 +139,7 @@ define noalias noundef ptr @SplittingStepCoefficients_Alloc(i32 noundef %0, i32
   br i1 %exitcond94.not, label %._crit_edge86, label %49
 
 .loopexit.sink.split:                             ; preds = %39, %44, %10
-  %.sink = phi ptr [ %16, %10 ], [ %19, %44 ], [ %19, %39 ]
+  %.sink = phi ptr [ %16, %10 ], [ %18, %42 ], [ %18, %37 ]
   tail call void @free(ptr noundef nonnull %.sink) #16
   tail call void @free(ptr noundef nonnull %8) #16
   br label %.loopexit
diff --git a/bench/syn/optimized/2i67i8azb4r5b3mw.ll b/bench/syn/optimized/2i67i8azb4r5b3mw.ll
index 577fbc0bf0d..01f4f726df2 100644
--- a/bench/syn/optimized/2i67i8azb4r5b3mw.ll
+++ b/bench/syn/optimized/2i67i8azb4r5b3mw.ll
@@ -1307,10 +1307,12 @@ define internal fastcc void @"_ZN4core3ptr90drop_in_place$LT$core..option..Optio
 4:                                                ; preds = %3
   %5 = landingpad { ptr, i32 }
           cleanup
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.0.val) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %.0.val, i64 noundef 328, i64 noundef 8) #26
   resume { ptr, i32 } %5
 
 "_ZN4core3ptr62drop_in_place$LT$alloc..boxed..Box$LT$syn..data..Field$GT$$GT$17hf57936b74d44e390E.exit": ; preds = %3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.0.val) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %.0.val, i64 noundef 328, i64 noundef 8) #26
   br label %2
 }
@@ -6992,10 +6994,12 @@ define hidden void @"_ZN3syn10punctuated23Punctuated$LT$T$C$P$GT$10push_punct17h
   %29 = add i64 %28, 1
   store i64 %29, ptr %14, align 8, !alias.scope !1419, !noalias !1422
   call void @llvm.lifetime.end.p0(ptr nonnull %3)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %6, i64 noundef 240, i64 noundef 8) #26
   ret void
 
 30:                                               ; preds = %19
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
   call void @__rust_dealloc(ptr noundef nonnull %6, i64 noundef 240, i64 noundef 8) #26
   resume { ptr, i32 } %20
 }
@@ -7582,6 +7586,7 @@ _ZN3syn5parse11ParseBuffer4span17h1ca0c8b0ffc956f0E.exit.i.i: ; preds = %55
   unreachable
 
 75:                                               ; preds = %71
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %60) ]
   call void @__rust_dealloc(ptr noundef nonnull %60, i64 noundef 296, i64 noundef 8) #26
   br label %.body
 
@@ -7608,6 +7613,7 @@ _ZN3syn5parse11ParseBuffer4span17h1ca0c8b0ffc956f0E.exit.i.i: ; preds = %55
   %82 = add i64 %79, 1
   store i64 %82, ptr %.sroa.523.0..sroa_idx, align 8, !alias.scope !1489, !noalias !1492
   call void @llvm.lifetime.end.p0(ptr nonnull %4), !noalias !1486
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %60) ]
   call void @__rust_dealloc(ptr noundef nonnull %60, i64 noundef 296, i64 noundef 8) #26
   %83 = load ptr, ptr %1, align 8, !noundef !64
   %84 = load ptr, ptr %16, align 8, !noundef !64
@@ -7906,6 +7912,7 @@ _ZN3syn5parse11ParseBuffer4span17h1ca0c8b0ffc956f0E.exit.i.i: ; preds = %55
   unreachable
 
 75:                                               ; preds = %71
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %60) ]
   call void @__rust_dealloc(ptr noundef nonnull %60, i64 noundef 176, i64 noundef 8) #26
   br label %.body
 
@@ -7932,6 +7939,7 @@ _ZN3syn5parse11ParseBuffer4span17h1ca0c8b0ffc956f0E.exit.i.i: ; preds = %55
   %82 = add i64 %79, 1
   store i64 %82, ptr %.sroa.523.0..sroa_idx, align 8, !alias.scope !1527, !noalias !1530
   call void @llvm.lifetime.end.p0(ptr nonnull %4), !noalias !1524
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %60) ]
   call void @__rust_dealloc(ptr noundef nonnull %60, i64 noundef 176, i64 noundef 8) #26
   %83 = load ptr, ptr %1, align 8, !noundef !64
   %84 = load ptr, ptr %16, align 8, !noundef !64
@@ -8191,6 +8199,7 @@ _ZN3syn5parse11ParseBuffer4span17h1ca0c8b0ffc956f0E.exit.i.i: ; preds = %55
   unreachable
 
 75:                                               ; preds = %71
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %60) ]
   call void @__rust_dealloc(ptr noundef nonnull %60, i64 noundef 328, i64 noundef 8) #26
   br label %.body
 
@@ -8217,6 +8226,7 @@ _ZN3syn5parse11ParseBuffer4span17h1ca0c8b0ffc956f0E.exit.i.i: ; preds = %55
   %82 = add i64 %79, 1
   store i64 %82, ptr %.sroa.523.0..sroa_idx, align 8, !alias.scope !1555, !noalias !1558
   call void @llvm.lifetime.end.p0(ptr nonnull %4), !noalias !1552
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %60) ]
   call void @__rust_dealloc(ptr noundef nonnull %60, i64 noundef 328, i64 noundef 8) #26
   %83 = load ptr, ptr %1, align 8, !noundef !64
   %84 = load ptr, ptr %16, align 8, !noundef !64
@@ -9893,6 +9903,7 @@ define hidden void @"_ZN102_$LT$syn..punctuated..Punctuated$LT$T$C$P$GT$$u20$as$
   %.sroa.06.0.copyload = load i64, ptr %9, align 8
   %.sroa.4.0..sroa_idx = getelementptr inbounds nuw i8, ptr %9, i64 8
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(320) %.sroa.5, ptr noundef nonnull align 8 dereferenceable(320) %.sroa.4.0..sroa_idx, i64 320, i1 false)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %9) ]
   call void @__rust_dealloc(ptr noundef nonnull %9, i64 noundef 328, i64 noundef 8) #26
   br label %19
 
@@ -10005,6 +10016,7 @@ define hidden void @"_ZN102_$LT$syn..punctuated..Punctuated$LT$T$C$P$GT$$u20$as$
   %.sroa.06.0.copyload = load i64, ptr %.val15, align 8
   %.sroa.4.0..sroa_idx = getelementptr inbounds nuw i8, ptr %.val15, i64 8
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(320) %.sroa.5, ptr noundef nonnull align 8 dereferenceable(320) %.sroa.4.0..sroa_idx, i64 320, i1 false)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val15) ]
   call void @__rust_dealloc(ptr noundef nonnull %.val15, i64 noundef 328, i64 noundef 8) #26
   br label %17
 
@@ -11613,6 +11625,7 @@ define hidden void @"_ZN3syn10punctuated8printing97_$LT$impl$u20$quote..to_token
   %7 = getelementptr inbounds nuw i8, ptr %0, i64 24
   %8 = load ptr, ptr %7, align 8, !alias.scope !2328, !noalias !2331, !noundef !64
   %9 = getelementptr inbounds { { { i64, [21 x i64] }, { { i64, ptr }, i64 }, { i64, [3 x i64] }, { i32, [1 x i32] } }, { [1 x i32] }, [1 x i32] }, ptr %4, i64 %6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %9) ]
   br label %"_ZN3syn10punctuated8printing91_$LT$impl$u20$quote..to_tokens..ToTokens$u20$for$u20$syn..punctuated..Pair$LT$T$C$P$GT$$GT$9to_tokens17hb0fd1541688be8f9E.exit.outer"
 
 "_ZN3syn10punctuated8printing91_$LT$impl$u20$quote..to_tokens..ToTokens$u20$for$u20$syn..punctuated..Pair$LT$T$C$P$GT$$GT$9to_tokens17hb0fd1541688be8f9E.exit.outer": ; preds = %"_ZN3syn10punctuated8printing91_$LT$impl$u20$quote..to_tokens..ToTokens$u20$for$u20$syn..punctuated..Pair$LT$T$C$P$GT$$GT$9to_tokens17hb0fd1541688be8f9E.exit.outer.backedge", %2
@@ -11622,6 +11635,7 @@ define hidden void @"_ZN3syn10punctuated8printing97_$LT$impl$u20$quote..to_token
 
 "_ZN3syn10punctuated8printing91_$LT$impl$u20$quote..to_tokens..ToTokens$u20$for$u20$syn..punctuated..Pair$LT$T$C$P$GT$$GT$9to_tokens17hb0fd1541688be8f9E.exit": ; preds = %"_ZN3syn10punctuated8printing91_$LT$impl$u20$quote..to_tokens..ToTokens$u20$for$u20$syn..punctuated..Pair$LT$T$C$P$GT$$GT$9to_tokens17hb0fd1541688be8f9E.exit.outer", %"_ZN52_$LT$$RF$T$u20$as$u20$quote..to_tokens..ToTokens$GT$9to_tokens17h66042a23a7b7bca7E.exit.i"
   %.sroa.0.0.i = phi ptr [ %14, %"_ZN52_$LT$$RF$T$u20$as$u20$quote..to_tokens..ToTokens$GT$9to_tokens17h66042a23a7b7bca7E.exit.i" ], [ %.sroa.0.0.i.ph, %"_ZN3syn10punctuated8printing91_$LT$impl$u20$quote..to_tokens..ToTokens$u20$for$u20$syn..punctuated..Pair$LT$T$C$P$GT$$GT$9to_tokens17hb0fd1541688be8f9E.exit.outer" ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.0.i) ]
   %10 = icmp eq ptr %.sroa.0.0.i, %9
   br i1 %10, label %11, label %13
 
@@ -11706,12 +11720,14 @@ define hidden void @"_ZN3syn10punctuated8printing97_$LT$impl$u20$quote..to_token
   %8 = getelementptr inbounds nuw i8, ptr %0, i64 24
   %9 = load ptr, ptr %8, align 8, !alias.scope !2370, !noalias !2373, !noundef !64
   %10 = getelementptr inbounds { { i64, [14 x i64] }, { [1 x i32] }, [1 x i32] }, ptr %5, i64 %7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %10) ]
   %.sroa.9.8..sroa_idx.i = getelementptr inbounds nuw i8, ptr %3, i64 8
   br label %11
 
 11:                                               ; preds = %18, %2
   %.sroa.6.0.i = phi ptr [ %9, %2 ], [ %.sroa.6.1.ph.i, %18 ]
   %.sroa.0.0.i = phi ptr [ %5, %2 ], [ %.sroa.0.1.ph.i, %18 ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.0.i) ]
   %12 = icmp eq ptr %.sroa.0.0.i, %10
   br i1 %12, label %13, label %15
 
@@ -11751,6 +11767,7 @@ define hidden void @"_ZN3syn10punctuated8printing97_$LT$impl$u20$quote..to_token
   %9 = getelementptr inbounds nuw i8, ptr %0, i64 24
   %10 = load ptr, ptr %9, align 8, !alias.scope !2380, !noalias !2383, !noundef !64
   %11 = getelementptr inbounds { { { i64, [28 x i64] }, { { i64, ptr }, i64 }, { i64, [4 x i64] } }, { [1 x i32] }, [1 x i32] }, ptr %6, i64 %8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %11) ]
   %12 = getelementptr inbounds nuw i8, ptr %4, i64 8
   %13 = getelementptr inbounds nuw i8, ptr %4, i64 16
   %14 = getelementptr inbounds nuw i8, ptr %3, i64 8
@@ -11764,6 +11781,7 @@ define hidden void @"_ZN3syn10punctuated8printing97_$LT$impl$u20$quote..to_token
 
 "_ZN3syn10punctuated8printing91_$LT$impl$u20$quote..to_tokens..ToTokens$u20$for$u20$syn..punctuated..Pair$LT$T$C$P$GT$$GT$9to_tokens17ha8f636f012a28e1bE.exit": ; preds = %"_ZN3syn10punctuated8printing91_$LT$impl$u20$quote..to_tokens..ToTokens$u20$for$u20$syn..punctuated..Pair$LT$T$C$P$GT$$GT$9to_tokens17ha8f636f012a28e1bE.exit.outer", %"_ZN52_$LT$$RF$T$u20$as$u20$quote..to_tokens..ToTokens$GT$9to_tokens17h8a2ab58f46441019E.exit.i"
   %.sroa.0.0.i = phi ptr [ %20, %"_ZN52_$LT$$RF$T$u20$as$u20$quote..to_tokens..ToTokens$GT$9to_tokens17h8a2ab58f46441019E.exit.i" ], [ %.sroa.0.0.i.ph, %"_ZN3syn10punctuated8printing91_$LT$impl$u20$quote..to_tokens..ToTokens$u20$for$u20$syn..punctuated..Pair$LT$T$C$P$GT$$GT$9to_tokens17ha8f636f012a28e1bE.exit.outer" ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.0.i) ]
   %16 = icmp eq ptr %.sroa.0.0.i, %11
   br i1 %16, label %17, label %19
 
diff --git a/bench/syn/optimized/4llvvcm7ykus6q9g.ll b/bench/syn/optimized/4llvvcm7ykus6q9g.ll
index feb108bd6a8..84281c1ed93 100644
--- a/bench/syn/optimized/4llvvcm7ykus6q9g.ll
+++ b/bench/syn/optimized/4llvvcm7ykus6q9g.ll
@@ -8341,8 +8341,9 @@ define hidden void @"_ZN4core3ptr47drop_in_place$LT$syn..lookahead..Lookahead1$G
 
 4:                                                ; preds = %1
   %5 = getelementptr inbounds nuw i8, ptr %0, i64 16
-  %.val1.i.i2.i.i.i = load ptr, ptr %5, align 8, !alias.scope !3879, !nonnull !4, !noundef !4
+  %.val1.i.i2.i.i.i = load ptr, ptr %5, align 8, !alias.scope !3879
   %6 = shl nuw i64 %.val.i.i1.i.i.i, 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1.i.i2.i.i.i) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %.val1.i.i2.i.i.i, i64 noundef %6, i64 noundef 8) #17, !noalias !3879
   br label %"_ZN4core3ptr78drop_in_place$LT$core..cell..RefCell$LT$alloc..vec..Vec$LT$$RF$str$GT$$GT$$GT$17hefbcd0d5b0d02b63E.llvm.8351105841907204142.exit"
 
@@ -9235,8 +9236,9 @@ define hidden void @"_ZN4core3ptr51drop_in_place$LT$alloc..vec..Vec$LT$$RF$str$G
 
 3:                                                ; preds = %1
   %4 = getelementptr inbounds nuw i8, ptr %0, i64 8
-  %.val1.i.i2 = load ptr, ptr %4, align 8, !alias.scope !4242, !nonnull !4, !noundef !4
+  %.val1.i.i2 = load ptr, ptr %4, align 8, !alias.scope !4242
   %5 = shl nuw i64 %.val.i.i1, 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1.i.i2) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %.val1.i.i2, i64 noundef %5, i64 noundef 8) #17, !noalias !4242
   br label %"_ZN4core3ptr58drop_in_place$LT$alloc..raw_vec..RawVec$LT$$RF$str$GT$$GT$17h183a8870e94296b3E.llvm.8351105841907204142.exit3"
 
@@ -9724,8 +9726,9 @@ define hidden void @"_ZN4core3ptr58drop_in_place$LT$alloc..raw_vec..RawVec$LT$$R
 
 3:                                                ; preds = %1
   %4 = getelementptr inbounds nuw i8, ptr %0, i64 8
-  %.val1.i = load ptr, ptr %4, align 8, !alias.scope !4451, !nonnull !4, !noundef !4
+  %.val1.i = load ptr, ptr %4, align 8, !alias.scope !4451
   %5 = shl nuw i64 %.val.i, 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1.i) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %.val1.i, i64 noundef %5, i64 noundef 8) #17, !noalias !4451
   br label %"_ZN77_$LT$alloc..raw_vec..RawVec$LT$T$C$A$GT$$u20$as$u20$core..ops..drop..Drop$GT$4drop17hf3bcb00eccf542ebE.llvm.8351105841907204142.exit"
 
@@ -13027,8 +13030,9 @@ define hidden void @"_ZN4core3ptr78drop_in_place$LT$core..cell..RefCell$LT$alloc
 
 4:                                                ; preds = %1
   %5 = getelementptr inbounds nuw i8, ptr %0, i64 16
-  %.val1.i.i2.i.i = load ptr, ptr %5, align 8, !alias.scope !5921, !nonnull !4, !noundef !4
+  %.val1.i.i2.i.i = load ptr, ptr %5, align 8, !alias.scope !5921
   %6 = shl nuw i64 %.val.i.i1.i.i, 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1.i.i2.i.i) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %.val1.i.i2.i.i, i64 noundef %6, i64 noundef 8) #17, !noalias !5921
   br label %"_ZN4core3ptr81drop_in_place$LT$core..cell..UnsafeCell$LT$alloc..vec..Vec$LT$$RF$str$GT$$GT$$GT$17hcbfe1f296c3d6a89E.llvm.8351105841907204142.exit"
 
@@ -13294,8 +13298,9 @@ define hidden void @"_ZN4core3ptr81drop_in_place$LT$core..cell..UnsafeCell$LT$al
 
 3:                                                ; preds = %1
   %4 = getelementptr inbounds nuw i8, ptr %0, i64 8
-  %.val1.i.i2.i = load ptr, ptr %4, align 8, !alias.scope !6012, !nonnull !4, !noundef !4
+  %.val1.i.i2.i = load ptr, ptr %4, align 8, !alias.scope !6012
   %5 = shl nuw i64 %.val.i.i1.i, 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1.i.i2.i) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %.val1.i.i2.i, i64 noundef %5, i64 noundef 8) #17, !noalias !6012
   br label %"_ZN4core3ptr51drop_in_place$LT$alloc..vec..Vec$LT$$RF$str$GT$$GT$17h0bdbbbf3baec0f1bE.llvm.8351105841907204142.exit"
 
@@ -18439,8 +18444,9 @@ define hidden void @"_ZN77_$LT$alloc..raw_vec..RawVec$LT$T$C$A$GT$$u20$as$u20$co
 
 3:                                                ; preds = %1
   %4 = getelementptr inbounds nuw i8, ptr %0, i64 8
-  %.val1 = load ptr, ptr %4, align 8, !nonnull !4, !noundef !4
+  %.val1 = load ptr, ptr %4, align 8
   %5 = shl nuw i64 %.val, 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1) ]
   tail call void @__rust_dealloc(ptr noundef nonnull %.val1, i64 noundef %5, i64 noundef 8) #17
   br label %"_ZN63_$LT$alloc..alloc..Global$u20$as$u20$core..alloc..Allocator$GT$10deallocate17hae8e459b587c5295E.llvm.8351105841907204142.exit"
 
@@ -18660,6 +18666,7 @@ define hidden void @"_ZN86_$LT$alloc..vec..into_iter..IntoIter$LT$T$C$A$GT$$u20$
   br i1 %10, label %"_ZN4core3ptr179drop_in_place$LT$$u5b$proc_macro..bridge..TokenTree$LT$proc_macro..bridge..client..TokenStream$C$proc_macro..bridge..client..Span$C$proc_macro..bridge..symbol..Symbol$GT$$u5d$$GT$17h85333a62a6317a64E.llvm.8351105841907204142.exit", label %.lr.ph.i
 
 .body:                                            ; preds = %"_ZN4core3ptr169drop_in_place$LT$proc_macro..bridge..TokenTree$LT$proc_macro..bridge..client..TokenStream$C$proc_macro..bridge..client..Span$C$proc_macro..bridge..symbol..Symbol$GT$$GT$17hbd14e643b3b111acE.exit8.i", %28
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   %11 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %12 = load i64, ptr %11, align 8, !noundef !4
   %13 = icmp eq i64 %12, 0
@@ -18730,6 +18737,7 @@ define hidden void @"_ZN86_$LT$alloc..vec..into_iter..IntoIter$LT$T$C$A$GT$$u20$
   unreachable
 
 "_ZN4core3ptr179drop_in_place$LT$$u5b$proc_macro..bridge..TokenTree$LT$proc_macro..bridge..client..TokenStream$C$proc_macro..bridge..client..Span$C$proc_macro..bridge..symbol..Symbol$GT$$u5d$$GT$17h85333a62a6317a64E.llvm.8351105841907204142.exit": ; preds = %"_ZN4core3ptr169drop_in_place$LT$proc_macro..bridge..TokenTree$LT$proc_macro..bridge..client..TokenStream$C$proc_macro..bridge..client..Span$C$proc_macro..bridge..symbol..Symbol$GT$$GT$17hbd14e643b3b111acE.exit.i", %1
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   %44 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %45 = load i64, ptr %44, align 8, !noundef !4
   %46 = icmp eq i64 %45, 0
@@ -19036,29 +19044,28 @@ define void @"_ZN65_$LT$syn..parse..ParseBuffer$u20$as$u20$core..ops..drop..Drop
   br i1 %switch.i, label %"_ZN4core3ptr43drop_in_place$LT$syn..parse..Unexpected$GT$17h5bf2b0fced757446E.llvm.8351105841907204142.exit", label %14
 
 14:                                               ; preds = %12
-  %15 = icmp ne ptr %.sroa.47.0.copyload, null
-  tail call void @llvm.assume(i1 %15)
-  %16 = load i64, ptr %.sroa.47.0.copyload, align 8, !noalias !7699, !noundef !4
-  %17 = add i64 %16, -1
-  store i64 %17, ptr %.sroa.47.0.copyload, align 8, !noalias !7699
-  %18 = icmp eq i64 %17, 0
-  br i1 %18, label %19, label %"_ZN4core3ptr43drop_in_place$LT$syn..parse..Unexpected$GT$17h5bf2b0fced757446E.llvm.8351105841907204142.exit"
-
-19:                                               ; preds = %14
-  %20 = getelementptr inbounds nuw i8, ptr %.sroa.47.0.copyload, i64 16
-  tail call void @"_ZN4core3ptr67drop_in_place$LT$core..cell..Cell$LT$syn..parse..Unexpected$GT$$GT$17haf2750eab111b2d0E"(ptr noalias noundef nonnull align 8 dereferenceable(16) %20), !noalias !7699
-  %21 = getelementptr inbounds nuw i8, ptr %.sroa.47.0.copyload, i64 8
-  %22 = load i64, ptr %21, align 8, !noalias !7699, !noundef !4
-  %23 = add i64 %22, -1
-  store i64 %23, ptr %21, align 8, !noalias !7699
-  %24 = icmp eq i64 %23, 0
-  br i1 %24, label %25, label %"_ZN4core3ptr43drop_in_place$LT$syn..parse..Unexpected$GT$17h5bf2b0fced757446E.llvm.8351105841907204142.exit"
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.47.0.copyload) ]
+  %15 = load i64, ptr %.sroa.47.0.copyload, align 8, !noalias !7699, !noundef !4
+  %16 = add i64 %15, -1
+  store i64 %16, ptr %.sroa.47.0.copyload, align 8, !noalias !7699
+  %17 = icmp eq i64 %16, 0
+  br i1 %17, label %18, label %"_ZN4core3ptr43drop_in_place$LT$syn..parse..Unexpected$GT$17h5bf2b0fced757446E.llvm.8351105841907204142.exit"
 
-25:                                               ; preds = %19
+18:                                               ; preds = %14
+  %19 = getelementptr inbounds nuw i8, ptr %.sroa.47.0.copyload, i64 16
+  tail call void @"_ZN4core3ptr67drop_in_place$LT$core..cell..Cell$LT$syn..parse..Unexpected$GT$$GT$17haf2750eab111b2d0E"(ptr noalias noundef nonnull align 8 dereferenceable(16) %19), !noalias !7699
+  %20 = getelementptr inbounds nuw i8, ptr %.sroa.47.0.copyload, i64 8
+  %21 = load i64, ptr %20, align 8, !noalias !7699, !noundef !4
+  %22 = add i64 %21, -1
+  store i64 %22, ptr %20, align 8, !noalias !7699
+  %23 = icmp eq i64 %22, 0
+  br i1 %23, label %24, label %"_ZN4core3ptr43drop_in_place$LT$syn..parse..Unexpected$GT$17h5bf2b0fced757446E.llvm.8351105841907204142.exit"
+
+25:                                               ; preds = %18
   tail call void @__rust_dealloc(ptr noundef nonnull %.sroa.47.0.copyload, i64 noundef 32, i64 noundef 8) #17, !noalias !7706
   br label %"_ZN4core3ptr43drop_in_place$LT$syn..parse..Unexpected$GT$17h5bf2b0fced757446E.llvm.8351105841907204142.exit"
 
-"_ZN4core3ptr43drop_in_place$LT$syn..parse..Unexpected$GT$17h5bf2b0fced757446E.llvm.8351105841907204142.exit": ; preds = %12, %14, %19, %25, %8
+"_ZN4core3ptr43drop_in_place$LT$syn..parse..Unexpected$GT$17h5bf2b0fced757446E.llvm.8351105841907204142.exit": ; preds = %12, %14, %18, %25, %8
   %26 = load i64, ptr %9, align 8, !noalias !7707, !noundef !4
   %27 = add i64 %26, -1
   store i64 %27, ptr %9, align 8, !noalias !7707
diff --git a/bench/syn/optimized/4pem7cta6fyqelao.ll b/bench/syn/optimized/4pem7cta6fyqelao.ll
index 8194ad089d5..102911c2adf 100644
--- a/bench/syn/optimized/4pem7cta6fyqelao.ll
+++ b/bench/syn/optimized/4pem7cta6fyqelao.ll
@@ -213,21 +213,20 @@ target triple = "x86_64-unknown-linux-gnu"
 @anon.cb776e29a3edfb21b922828375758a83.4.llvm.11864023271123110445 = external hidden unnamed_addr constant <{}>, align 8
 
 ; Function Attrs: mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: read, inaccessiblemem: write) uwtable
-define hidden { i64, i64 } @"_ZN4core3ops5range18Bound$LT$$RF$T$GT$6cloned17hb6ca3650398b6db3E"(i64 noundef %0, ptr readonly captures(address_is_null) %1) unnamed_addr #0 {
+define hidden { i64, i64 } @"_ZN4core3ops5range18Bound$LT$$RF$T$GT$6cloned17hb6ca3650398b6db3E"(i64 noundef %0, ptr readonly captures(none) %1) unnamed_addr #0 {
   %3 = icmp eq i64 %0, 2
-  br i1 %3, label %6, label %.sink.split
+  br i1 %3, label %5, label %.sink.split
 
 .sink.split:                                      ; preds = %2
-  %4 = icmp ne ptr %1, null
-  tail call void @llvm.assume(i1 %4)
-  %5 = load i64, ptr %1, align 8, !noundef !4
-  br label %6
-
-6:                                                ; preds = %2, %.sink.split
-  %.sroa.4.0 = phi i64 [ undef, %2 ], [ %5, %.sink.split ]
-  %7 = insertvalue { i64, i64 } poison, i64 %0, 0
-  %8 = insertvalue { i64, i64 } %7, i64 %.sroa.4.0, 1
-  ret { i64, i64 } %8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
+  %4 = load i64, ptr %1, align 8, !noundef !4
+  br label %5
+
+5:                                                ; preds = %2, %.sink.split
+  %.sroa.4.0 = phi i64 [ undef, %2 ], [ %4, %.sink.split ]
+  %6 = insertvalue { i64, i64 } poison, i64 %0, 0
+  %7 = insertvalue { i64, i64 } %6, i64 %.sroa.4.0, 1
+  ret { i64, i64 } %7
 }
 
 ; Function Attrs: inlinehint nonlazybind uwtable
diff --git a/bench/tikv-rs/optimized/4sohgqjmmmwbwrelv7h1i20q9.ll b/bench/tikv-rs/optimized/4sohgqjmmmwbwrelv7h1i20q9.ll
index 690c9a7188d..bd21dc4a0fa 100644
--- a/bench/tikv-rs/optimized/4sohgqjmmmwbwrelv7h1i20q9.ll
+++ b/bench/tikv-rs/optimized/4sohgqjmmmwbwrelv7h1i20q9.ll
@@ -38,9 +38,11 @@ define noundef zeroext i1 @"_ZN67_$LT$tikv_alloc..error..ProfError$u20$as$u20$co
   ]
 
 17:                                               ; preds = %2
-  %.val23 = load ptr, ptr %1, align 8, !nonnull !4, !noundef !4
+  %.val23 = load ptr, ptr %1, align 8
   %18 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val24 = load ptr, ptr %18, align 8, !nonnull !4, !noundef !4
+  %.val24 = load ptr, ptr %18, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val23) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val24) ]
   %19 = getelementptr inbounds nuw i8, ptr %.val24, i64 24
   %20 = load ptr, ptr %19, align 8, !invariant.load !4, !noalias !5, !nonnull !4
   %21 = tail call noundef zeroext i1 %20(ptr noundef nonnull align 1 %.val23, ptr noalias noundef nonnull readonly align 1 @anon.365fb1c0c7b0cc2ca1d4ff4f5970e169.1, i64 noundef 29), !noalias !5
@@ -54,9 +56,11 @@ _ZN4core3fmt9Formatter9write_fmt17h3bce49d3b5fbe92dE.exit29: ; preds = %2
   store ptr %14, ptr %13, align 8
   %.sroa.415.0..sroa_idx = getelementptr inbounds nuw i8, ptr %13, i64 8
   store ptr @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$GT$3fmt17h483f12d44b88e77cE", ptr %.sroa.415.0..sroa_idx, align 8
-  %.val21 = load ptr, ptr %1, align 8, !nonnull !4, !noundef !4
+  %.val21 = load ptr, ptr %1, align 8
   %23 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val22 = load ptr, ptr %23, align 8, !nonnull !4, !noundef !4
+  %.val22 = load ptr, ptr %23, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val21) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val22) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %6), !noalias !8
   store ptr @anon.365fb1c0c7b0cc2ca1d4ff4f5970e169.4, ptr %6, align 8
   %.sroa.546.0..sroa_idx = getelementptr inbounds nuw i8, ptr %6, i64 8
@@ -81,9 +85,11 @@ _ZN4core3fmt9Formatter9write_fmt17h3bce49d3b5fbe92dE.exit34: ; preds = %2
   store ptr %12, ptr %11, align 8
   %.sroa.411.0..sroa_idx = getelementptr inbounds nuw i8, ptr %11, i64 8
   store ptr @"_ZN44_$LT$$RF$T$u20$as$u20$core..fmt..Display$GT$3fmt17ha3f27742683d87eeE", ptr %.sroa.411.0..sroa_idx, align 8
-  %.val19 = load ptr, ptr %1, align 8, !nonnull !4, !noundef !4
+  %.val19 = load ptr, ptr %1, align 8
   %26 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val20 = load ptr, ptr %26, align 8, !nonnull !4, !noundef !4
+  %.val20 = load ptr, ptr %26, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val19) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val20) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %5), !noalias !11
   store ptr @anon.365fb1c0c7b0cc2ca1d4ff4f5970e169.6, ptr %5, align 8
   %.sroa.552.0..sroa_idx = getelementptr inbounds nuw i8, ptr %5, i64 8
@@ -108,9 +114,11 @@ _ZN4core3fmt9Formatter9write_fmt17h3bce49d3b5fbe92dE.exit39: ; preds = %2
   store ptr %10, ptr %9, align 8
   %.sroa.47.0..sroa_idx = getelementptr inbounds nuw i8, ptr %9, i64 8
   store ptr @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$GT$3fmt17h0ee4b9ed483bd16dE", ptr %.sroa.47.0..sroa_idx, align 8
-  %.val17 = load ptr, ptr %1, align 8, !nonnull !4, !noundef !4
+  %.val17 = load ptr, ptr %1, align 8
   %29 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val18 = load ptr, ptr %29, align 8, !nonnull !4, !noundef !4
+  %.val18 = load ptr, ptr %29, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val17) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val18) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !14
   store ptr @anon.365fb1c0c7b0cc2ca1d4ff4f5970e169.9, ptr %4, align 8
   %.sroa.558.0..sroa_idx = getelementptr inbounds nuw i8, ptr %4, i64 8
@@ -134,9 +142,11 @@ _ZN4core3fmt9Formatter9write_fmt17h3bce49d3b5fbe92dE.exit44: ; preds = %2
   store ptr %8, ptr %7, align 8
   %.sroa.43.0..sroa_idx = getelementptr inbounds nuw i8, ptr %7, i64 8
   store ptr @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$GT$3fmt17h8c0e8ec45c57c57eE", ptr %.sroa.43.0..sroa_idx, align 8
-  %.val = load ptr, ptr %1, align 8, !nonnull !4, !noundef !4
+  %.val = load ptr, ptr %1, align 8
   %31 = getelementptr inbounds nuw i8, ptr %1, i64 8
-  %.val16 = load ptr, ptr %31, align 8, !nonnull !4, !noundef !4
+  %.val16 = load ptr, ptr %31, align 8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val16) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !17
   store ptr @anon.365fb1c0c7b0cc2ca1d4ff4f5970e169.11, ptr %3, align 8
   %.sroa.564.0..sroa_idx = getelementptr inbounds nuw i8, ptr %3, i64 8
@@ -196,11 +206,15 @@ declare void @llvm.lifetime.start.p0(ptr captures(none)) #4
 ; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite)
 declare void @llvm.lifetime.end.p0(ptr captures(none)) #4
 
+; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #5
+
 attributes #0 = { nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #1 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: write) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #2 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(argmem: readwrite) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #3 = { mustprogress nocallback nofree nounwind willreturn memory(argmem: readwrite) }
 attributes #4 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
+attributes #5 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
 
 !llvm.module.flags = !{!0, !1}
 !llvm.ident = !{!2}
diff --git a/bench/tikv-rs/optimized/96y9hk39bcjsdy0glqmdl20ki.ll b/bench/tikv-rs/optimized/96y9hk39bcjsdy0glqmdl20ki.ll
index bb2d06d5e4e..3fe12e44385 100644
--- a/bench/tikv-rs/optimized/96y9hk39bcjsdy0glqmdl20ki.ll
+++ b/bench/tikv-rs/optimized/96y9hk39bcjsdy0glqmdl20ki.ll
@@ -5,34 +5,33 @@ target triple = "x86_64-unknown-linux-gnu"
 
 ; Function Attrs: nonlazybind uwtable
 define hidden void @"_ZN132_$LT$alloc..vec..Vec$LT$T$C$A$GT$$u20$as$u20$alloc..vec..spec_extend..SpecExtend$LT$$RF$T$C$core..slice..iter..Iter$LT$T$GT$$GT$$GT$11spec_extend17h5abec2e9a6b8744fE"(ptr noalias noundef align 8 dereferenceable(24) %0, ptr noundef nonnull %1, ptr noundef %2, ptr noalias noundef readonly align 8 captures(none) dereferenceable(24) %3) unnamed_addr #0 {
-  %5 = icmp ne ptr %2, null
-  tail call void @llvm.assume(i1 %5)
-  %6 = ptrtoint ptr %2 to i64
-  %7 = ptrtoint ptr %1 to i64
-  %8 = sub nuw i64 %6, %7
-  %9 = getelementptr inbounds nuw i8, ptr %0, i64 16
-  %10 = load i64, ptr %9, align 8, !alias.scope !3, !noundef !8
-  %11 = load i64, ptr %0, align 8, !range !9, !alias.scope !3, !noundef !8
-  %12 = sub i64 %11, %10
-  %13 = icmp ugt i64 %8, %12
-  br i1 %13, label %14, label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$15append_elements17hc308b1263dd722a4E.exit", !prof !10
-
-14:                                               ; preds = %4
-  tail call void @"_ZN5alloc7raw_vec20RawVecInner$LT$A$GT$7reserve21do_reserve_and_handle17h8495e18a400fd0c6E"(ptr noalias noundef nonnull align 8 dereferenceable(24) %0, i64 noundef %10, i64 noundef %8, i64 noundef 1, i64 noundef 1)
-  %.pre.i = load i64, ptr %9, align 8, !alias.scope !11
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %2) ]
+  %5 = ptrtoint ptr %2 to i64
+  %6 = ptrtoint ptr %1 to i64
+  %7 = sub nuw i64 %5, %6
+  %8 = getelementptr inbounds nuw i8, ptr %0, i64 16
+  %9 = load i64, ptr %8, align 8, !alias.scope !3, !noundef !8
+  %10 = load i64, ptr %0, align 8, !range !9, !alias.scope !3, !noundef !8
+  %11 = sub i64 %10, %9
+  %12 = icmp ugt i64 %7, %11
+  br i1 %12, label %13, label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$15append_elements17hc308b1263dd722a4E.exit", !prof !10
+
+13:                                               ; preds = %4
+  tail call void @"_ZN5alloc7raw_vec20RawVecInner$LT$A$GT$7reserve21do_reserve_and_handle17h8495e18a400fd0c6E"(ptr noalias noundef nonnull align 8 dereferenceable(24) %0, i64 noundef %9, i64 noundef %7, i64 noundef 1, i64 noundef 1)
+  %.pre.i = load i64, ptr %8, align 8, !alias.scope !11
   br label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$15append_elements17hc308b1263dd722a4E.exit"
 
-"_ZN5alloc3vec16Vec$LT$T$C$A$GT$15append_elements17hc308b1263dd722a4E.exit": ; preds = %4, %14
-  %15 = phi i64 [ %10, %4 ], [ %.pre.i, %14 ]
+"_ZN5alloc3vec16Vec$LT$T$C$A$GT$15append_elements17hc308b1263dd722a4E.exit": ; preds = %4, %13
+  %15 = phi i64 [ %9, %4 ], [ %.pre.i, %13 ]
   %16 = icmp sgt i64 %15, -1
   tail call void @llvm.assume(i1 %16)
   %17 = getelementptr inbounds nuw i8, ptr %0, i64 8
   %18 = load ptr, ptr %17, align 8, !alias.scope !11, !nonnull !8, !noundef !8
   %19 = getelementptr inbounds nuw i8, ptr %18, i64 %15
-  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %19, ptr nonnull readonly align 1 %1, i64 %8, i1 false)
-  %20 = load i64, ptr %9, align 8, !alias.scope !11, !noundef !8
-  %21 = add i64 %20, %8
-  store i64 %21, ptr %9, align 8, !alias.scope !11
+  tail call void @llvm.memcpy.p0.p0.i64(ptr nonnull align 1 %19, ptr nonnull readonly align 1 %1, i64 %7, i1 false)
+  %20 = load i64, ptr %8, align 8, !alias.scope !11, !noundef !8
+  %21 = add i64 %20, %7
+  store i64 %21, ptr %8, align 8, !alias.scope !11
   ret void
 }
 
@@ -43,6 +42,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %.val = load ptr, ptr %4, align 8, !nonnull !8, !noundef !8
   %5 = getelementptr i8, ptr %3, i64 16
   %.val1 = load i64, ptr %5, align 8, !noundef !8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %6 = tail call noundef zeroext i1 @"_ZN48_$LT$$u5b$T$u5d$$u20$as$u20$core..fmt..Debug$GT$3fmt17h357ece8b4bcec3a3E"(ptr noalias noundef nonnull readonly align 1 %.val, i64 noundef %.val1, ptr noalias noundef nonnull align 8 dereferenceable(24) %1)
   ret i1 %6
 }
@@ -70,6 +70,7 @@ define hidden void @"_ZN98_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..s
 
 "_ZN102_$LT$core..iter..adapters..map..Map$LT$I$C$F$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17h8973db8c426526dbE.exit.i": ; preds = %3
   %.val.i.i = load ptr, ptr %13, align 8, !noalias !20, !nonnull !8, !noundef !8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i.i) ]
   %14 = getelementptr inbounds nuw i8, ptr %.val.i.i, i64 16
   call void @_ZN10tikv_alloc5trace11MemoryTrace8snapshot17h070aa5a6ee7de5cfE(ptr noalias noundef nonnull sret([48 x i8]) align 8 captures(none) dereferenceable(48) %8, ptr noundef nonnull align 8 %14), !noalias !23
   %.pr.i = load i64, ptr %8, align 8, !noalias !18
@@ -154,6 +155,7 @@ define hidden void @"_ZN98_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..s
 "_ZN102_$LT$core..iter..adapters..map..Map$LT$I$C$F$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17h8973db8c426526dbE.exit.i.i.i": ; preds = %.noexc9.i, %"_ZN102_$LT$core..iter..adapters..map..Map$LT$I$C$F$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17h8973db8c426526dbE.exit.lr.ph.i.i.i"
   %36 = phi ptr [ %34, %"_ZN102_$LT$core..iter..adapters..map..Map$LT$I$C$F$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17h8973db8c426526dbE.exit.lr.ph.i.i.i" ], [ %48, %.noexc9.i ]
   %.val.i.i.i.i = load ptr, ptr %36, align 8, !noalias !41, !nonnull !8, !noundef !8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i.i.i.i) ]
   %37 = getelementptr inbounds nuw i8, ptr %.val.i.i.i.i, i64 16
   invoke void @_ZN10tikv_alloc5trace11MemoryTrace8snapshot17h070aa5a6ee7de5cfE(ptr noalias noundef nonnull sret([48 x i8]) align 8 captures(none) dereferenceable(48) %4, ptr noundef nonnull align 8 %37)
           to label %.noexc8.i unwind label %.loopexit.i, !noalias !23
@@ -257,6 +259,8 @@ define hidden void @"_ZN98_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..s
   %.val.i = load ptr, ptr %1, align 8, !alias.scope !49, !noalias !55, !nonnull !8, !noundef !8
   %8 = getelementptr inbounds nuw i8, ptr %1, i64 8
   %.val3.i = load ptr, ptr %8, align 8, !alias.scope !49, !noalias !55, !nonnull !8, !noundef !8
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3.i) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   %9 = ptrtoint ptr %.val3.i to i64
   %10 = ptrtoint ptr %.val.i to i64
   %11 = sub nuw i64 %9, %10
@@ -288,6 +292,8 @@ define hidden void @"_ZN98_$LT$alloc..vec..Vec$LT$T$GT$$u20$as$u20$alloc..vec..s
   %.sroa.6.0..sroa_idx10.i = getelementptr inbounds nuw i8, ptr %5, i64 16
   call void @llvm.lifetime.start.p0(ptr nonnull %5), !noalias !60
   call void @llvm.memcpy.p0.p0.i64(ptr noundef nonnull align 8 dereferenceable(16) %.sroa.6.0..sroa_idx10.i, ptr noundef nonnull readonly align 8 dereferenceable(16) %.sroa.6.0..sroa_idx.i, i64 16, i1 false), !noalias !55
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3.i) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   store ptr %.val.i, ptr %5, align 8, !noalias !67
   %.sroa.57.0..sroa_idx8.i = getelementptr inbounds nuw i8, ptr %5, i64 8
   store ptr %.val3.i, ptr %.sroa.57.0..sroa_idx8.i, align 8, !noalias !67
diff --git a/bench/tikv-rs/optimized/ck1kcp78m0uk16uxeow74g4c6.ll b/bench/tikv-rs/optimized/ck1kcp78m0uk16uxeow74g4c6.ll
index 5c03f44350b..1b7c13f96eb 100644
--- a/bench/tikv-rs/optimized/ck1kcp78m0uk16uxeow74g4c6.ll
+++ b/bench/tikv-rs/optimized/ck1kcp78m0uk16uxeow74g4c6.ll
@@ -3,8 +3,9 @@ source_filename = "bench/tikv-rs/original/ck1kcp78m0uk16uxeow74g4c6.ll"
 target datalayout = "e-m:e-p270:32:32-p271:32:32-p272:64:64-i64:64-i128:128-f80:128-n8:16:32:64-S128"
 target triple = "x86_64-unknown-linux-gnu"
 
-; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable
+; Function Attrs: nofree norecurse nosync nounwind nonlazybind memory(read, inaccessiblemem: write, target_mem0: none, target_mem1: none) uwtable
 define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h439cdb546578af0bE(ptr noalias noundef nonnull readonly align 1 captures(none) %0, ptr noalias noundef readonly align 8 captures(none) dereferenceable(16) %1) unnamed_addr #0 personality ptr @rust_eh_personality {
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load ptr, ptr %1, align 8, !noalias !3, !noundef !6
   %3 = getelementptr inbounds nuw i8, ptr %1, i64 8
   %.val1.i = load i64, ptr %3, align 8, !noalias !3
@@ -87,9 +88,13 @@ declare noundef range(i32 0, 10) i32 @rust_eh_personality(i32 noundef, i32 nound
 ; Function Attrs: mustprogress nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none)
 declare i64 @llvm.fshl.i64(i64, i64, i64) #2
 
-attributes #0 = { nofree norecurse nosync nounwind nonlazybind memory(read, inaccessiblemem: none, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
+attributes #0 = { nofree norecurse nosync nounwind nonlazybind memory(read, inaccessiblemem: mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #3
+
+attributes #0 = { nofree norecurse nosync nounwind nonlazybind memory(read, inaccessiblemem: write, target_mem0: none, target_mem1: none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #1 = { nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #2 = { mustprogress nocallback nocreateundeforpoison nofree nosync nounwind speculatable willreturn memory(none) }
+attributes #3 = { mustprogress nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
 
 !llvm.module.flags = !{!0, !1}
 !llvm.ident = !{!2}
diff --git a/bench/turborepo-rs/optimized/06q4qae34rflpqcqgg2nvmi9u.ll b/bench/turborepo-rs/optimized/06q4qae34rflpqcqgg2nvmi9u.ll
index 44b8f563f8d..3f3d45f3fca 100644
--- a/bench/turborepo-rs/optimized/06q4qae34rflpqcqgg2nvmi9u.ll
+++ b/bench/turborepo-rs/optimized/06q4qae34rflpqcqgg2nvmi9u.ll
@@ -99,6 +99,7 @@ define hidden void @_RINvYNtCseBw3mChBYfU_3hex15BytesToHexCharsNtNtNtNtCs1LoaDTb
   br i1 %4, label %._crit_edge, label %.lr.ph
 
 .lr.ph:                                           ; preds = %2
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.sroa.0.i.i.i.1.i.i.i.1.i.i.i.1.i.i.1.i.i.1.i.1.i.1.gep.sroa_idx = getelementptr inbounds nuw i8, ptr %.sroa.0.i.i.i, i64 1
   %.sroa.0.i.i.i.2.i.i.i.2.i.i.i.2.i.i.2.i.i.2.i.2.i.2.gep1.sroa_idx = getelementptr inbounds nuw i8, ptr %.sroa.0.i.i.i, i64 2
   %.sroa.0.i.i.i.3.i.i.i.3.i.i.i.3.i.i.3.i.i.3.i.3.i.3.gep2.sroa_idx = getelementptr inbounds nuw i8, ptr %.sroa.0.i.i.i, i64 3
@@ -319,6 +320,9 @@ declare void @llvm.lifetime.end.p0(ptr captures(none)) #8
 ; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite)
 declare void @llvm.experimental.noalias.scope.decl(metadata) #9
 
+; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #10
+
 attributes #0 = { nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #1 = { inlinehint nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #2 = { mustprogress nofree norecurse nosync nounwind nonlazybind willreturn memory(none) uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
@@ -329,8 +333,9 @@ attributes #6 = { cold noreturn nounwind nonlazybind uwtable "probe-stack"="inli
 attributes #7 = { cold nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #8 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
 attributes #9 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
-attributes #10 = { cold }
-attributes #11 = { cold noreturn nounwind }
+attributes #10 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #11 = { cold }
+attributes #12 = { cold noreturn nounwind }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/turborepo-rs/optimized/4npj4wsmg2ap1thdgni5ygdc7.ll b/bench/turborepo-rs/optimized/4npj4wsmg2ap1thdgni5ygdc7.ll
index 83b720146ed..ec0d58888dc 100644
--- a/bench/turborepo-rs/optimized/4npj4wsmg2ap1thdgni5ygdc7.ll
+++ b/bench/turborepo-rs/optimized/4npj4wsmg2ap1thdgni5ygdc7.ll
@@ -58,6 +58,8 @@ define noundef i64 @_RINvNtNtNtNtCs1LoaDTb72WA_4core5slice4sort6stable9quicksort
   %.val10.us = load i64, ptr %25, align 8, !noundef !7
   %.val11.us = load ptr, ptr %13, align 8, !nonnull !7, !noundef !7
   %.val12.us = load i64, ptr %14, align 8, !noundef !7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val11.us) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.us) ]
   %26 = tail call noundef range(i8 -1, 3) i8 @_RNvXs5_NtNtCs1LoaDTb72WA_4core5slice3cmphNtB5_15SlicePartialOrd15partial_compareCsgrIngBG6lgl_14regex_automata(ptr noalias noundef nonnull readonly align 1 %.val11.us, i64 noundef %.val12.us, ptr noalias noundef nonnull readonly align 1 %.val.us, i64 noundef %.val10.us), !range !8
   %27 = icmp ne i8 %26, -1
   %28 = getelementptr inbounds i8, ptr %.sroa.19.125.us, i64 -24
@@ -100,6 +102,8 @@ define noundef i64 @_RINvNtNtNtNtCs1LoaDTb72WA_4core5slice4sort6stable9quicksort
   %.val10 = load i64, ptr %39, align 8, !noundef !7
   %.val11 = load ptr, ptr %13, align 8, !nonnull !7, !noundef !7
   %.val12 = load i64, ptr %14, align 8, !noundef !7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val11) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %40 = tail call noundef range(i8 -1, 3) i8 @_RNvXs5_NtNtCs1LoaDTb72WA_4core5slice3cmphNtB5_15SlicePartialOrd15partial_compareCsgrIngBG6lgl_14regex_automata(ptr noalias noundef nonnull readonly align 1 %.val11, i64 noundef %.val12, ptr noalias noundef nonnull readonly align 1 %.val, i64 noundef %.val10), !range !8
   %41 = icmp ne i8 %40, -1
   %42 = getelementptr inbounds i8, ptr %.sroa.19.125, i64 -24
@@ -195,6 +199,8 @@ define noundef i64 @_RINvNtNtNtNtCs1LoaDTb72WA_4core5slice4sort6stable9quicksort
   %.val10.us = load i64, ptr %25, align 8, !noundef !7
   %.val11.us = load ptr, ptr %13, align 8, !nonnull !7, !noundef !7
   %.val12.us = load i64, ptr %14, align 8, !noundef !7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.us) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val11.us) ]
   %26 = tail call noundef range(i8 -1, 3) i8 @_RNvXs5_NtNtCs1LoaDTb72WA_4core5slice3cmphNtB5_15SlicePartialOrd15partial_compareCsgrIngBG6lgl_14regex_automata(ptr noalias noundef nonnull readonly align 1 %.val.us, i64 noundef %.val10.us, ptr noalias noundef nonnull readonly align 1 %.val11.us, i64 noundef %.val12.us), !range !8
   %27 = icmp eq i8 %26, -1
   %28 = getelementptr inbounds i8, ptr %.sroa.19.125.us, i64 -24
@@ -237,6 +243,8 @@ define noundef i64 @_RINvNtNtNtNtCs1LoaDTb72WA_4core5slice4sort6stable9quicksort
   %.val10 = load i64, ptr %39, align 8, !noundef !7
   %.val11 = load ptr, ptr %13, align 8, !nonnull !7, !noundef !7
   %.val12 = load i64, ptr %14, align 8, !noundef !7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val11) ]
   %40 = tail call noundef range(i8 -1, 3) i8 @_RNvXs5_NtNtCs1LoaDTb72WA_4core5slice3cmphNtB5_15SlicePartialOrd15partial_compareCsgrIngBG6lgl_14regex_automata(ptr noalias noundef nonnull readonly align 1 %.val, i64 noundef %.val10, ptr noalias noundef nonnull readonly align 1 %.val11, i64 noundef %.val12), !range !8
   %41 = icmp eq i8 %40, -1
   %42 = getelementptr inbounds i8, ptr %.sroa.19.125, i64 -24
@@ -368,6 +376,8 @@ _RINvNtNtNtNtCs1LoaDTb72WA_4core5slice4sort6shared5pivot12choose_pivotNtNtCs68wO
   %.val = load ptr, ptr %42, align 8, !nonnull !7, !noundef !7
   %43 = getelementptr i8, ptr %39, i64 16
   %.val30 = load i64, ptr %43, align 8, !noundef !7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.022.0.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %44 = call noundef range(i8 -1, 3) i8 @_RNvXs5_NtNtCs1LoaDTb72WA_4core5slice3cmphNtB5_15SlicePartialOrd15partial_compareCsgrIngBG6lgl_14regex_automata(ptr noalias noundef nonnull readonly align 1 %.sroa.022.0.val, i64 noundef %.sroa.022.0.val29, ptr noalias noundef nonnull readonly align 1 %.val, i64 noundef %.val30), !range !8
   %.not43 = icmp eq i8 %44, -1
   br i1 %.not43, label %.thread, label %.thread40
@@ -414,6 +424,8 @@ _RINvNtNtNtNtCs1LoaDTb72WA_4core5slice4sort6shared5pivot12choose_pivotNtNtCs68wO
   %.val10.i = load i64, ptr %55, align 8, !alias.scope !24, !noalias !27, !noundef !7
   %.val11.i = load ptr, ptr %48, align 8, !alias.scope !24, !noalias !27, !nonnull !7, !noundef !7
   %.val12.i = load i64, ptr %49, align 8, !alias.scope !24, !noalias !27, !noundef !7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val11.i) ]
   %56 = call noundef range(i8 -1, 3) i8 @_RNvXs5_NtNtCs1LoaDTb72WA_4core5slice3cmphNtB5_15SlicePartialOrd15partial_compareCsgrIngBG6lgl_14regex_automata(ptr noalias noundef nonnull readonly align 1 %.val.i, i64 noundef %.val10.i, ptr noalias noundef nonnull readonly align 1 %.val11.i, i64 noundef %.val12.i), !range !8, !noalias !29
   %57 = icmp eq i8 %56, -1
   %58 = getelementptr inbounds i8, ptr %.sroa.19.125.i, i64 -24
@@ -508,6 +520,8 @@ _RINvNtNtNtNtCs1LoaDTb72WA_4core5slice4sort6shared5pivot12choose_pivotNtNtCs68wO
   %.val10.us.i = load i64, ptr %92, align 8, !alias.scope !36, !noalias !39, !noundef !7
   %.val11.us.i = load ptr, ptr %81, align 8, !alias.scope !36, !noalias !39, !nonnull !7, !noundef !7
   %.val12.us.i = load i64, ptr %82, align 8, !alias.scope !36, !noalias !39, !noundef !7
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val11.us.i) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.us.i) ]
   %93 = call noundef range(i8 -1, 3) i8 @_RNvXs5_NtNtCs1LoaDTb72WA_4core5slice3cmphNtB5_15SlicePartialOrd15partial_compareCsgrIngBG6lgl_14regex_automata(ptr noalias noundef nonnull readonly align 1 %.val11.us.i, i64 noundef %.val12.us.i, ptr noalias noundef nonnull readonly align 1 %.val.us.i, i64 noundef %.val10.us.i), !range !8, !noalias !41
   %94 = icmp ne i8 %93, -1
   %95 = getelementptr inbounds i8, ptr %.sroa.19.125.us.i, i64 -24
@@ -576,6 +590,7 @@ _RNvXs5_NtNtCs1LoaDTb72WA_4core5slice5indexINtNtNtB9_3ops5range9RangeFromjEINtB5
 
 118:                                              ; preds = %77
   %119 = getelementptr inbounds { { { i64, ptr, {} }, i64 } }, ptr %.sroa.0.0.ph75, i64 %.sroa.11.1.lcssa.i
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.sroa.0.0.ph75) ]
   call void @_RINvNtNtNtNtCs1LoaDTb72WA_4core5slice4sort6stable9quicksort9quicksortNtNtCs68wO5nsWeTG_5alloc6string6StringNvYB15_NtNtBa_3cmp10PartialOrd2ltECsff1zCjKRl2o_13turborepo_env(ptr noalias noundef nonnull align 8 %119, i64 noundef %69, ptr noalias noundef nonnull align 8 %2, i64 noundef %3, i32 noundef %19, ptr noalias noundef nonnull readonly align 8 dereferenceable_or_null(24) %9, ptr noalias noundef nonnull align 1 %6)
   call void @llvm.lifetime.end.p0(ptr nonnull %9)
   %120 = icmp ult i64 %.sroa.11.1.lcssa.i, 33
diff --git a/bench/turborepo-rs/optimized/aooodqa4noqfp1f79p9le8248.ll b/bench/turborepo-rs/optimized/aooodqa4noqfp1f79p9le8248.ll
index ab48bdbb12b..2aae1cc0034 100644
--- a/bench/turborepo-rs/optimized/aooodqa4noqfp1f79p9le8248.ll
+++ b/bench/turborepo-rs/optimized/aooodqa4noqfp1f79p9le8248.ll
@@ -12,6 +12,7 @@ define noundef zeroext i1 @_RNvXsP_NtCs1LoaDTb72WA_4core3fmtRNtNtCs68wO5nsWeTG_5
   %.val = load ptr, ptr %4, align 8, !nonnull !4, !noundef !4
   %5 = getelementptr i8, ptr %3, i64 16
   %.val1 = load i64, ptr %5, align 8, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %6 = tail call noundef zeroext i1 @"_ZN40_$LT$str$u20$as$u20$core..fmt..Debug$GT$3fmt17hf13399e56476983fE"(ptr noalias noundef nonnull readonly align 1 %.val, i64 noundef %.val1, ptr noalias noundef nonnull align 8 dereferenceable(64) %1)
   ret i1 %6
 }
@@ -23,6 +24,7 @@ define noundef zeroext i1 @_RNvXsR_NtCs1LoaDTb72WA_4core3fmtRNtNtCs68wO5nsWeTG_5
   %.val = load ptr, ptr %4, align 8, !nonnull !4, !noundef !4
   %5 = getelementptr i8, ptr %3, i64 16
   %.val1 = load i64, ptr %5, align 8, !noundef !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %6 = tail call noundef zeroext i1 @"_ZN42_$LT$str$u20$as$u20$core..fmt..Display$GT$3fmt17hee1d20a2d69c4613E"(ptr noalias noundef nonnull readonly align 1 %.val, i64 noundef %.val1, ptr noalias noundef nonnull align 8 dereferenceable(64) %1)
   ret i1 %6
 }
@@ -211,6 +213,9 @@ declare void @llvm.lifetime.start.p0(ptr captures(none)) #5
 ; Function Attrs: mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite)
 declare void @llvm.lifetime.end.p0(ptr captures(none)) #5
 
+; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write)
+declare void @llvm.assume(i1 noundef) #6
+
 ; Function Attrs: nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite)
 declare void @llvm.experimental.noalias.scope.decl(metadata) #6
 
@@ -220,7 +225,8 @@ attributes #2 = { mustprogress nocallback nofree nounwind willreturn memory(argm
 attributes #3 = { nounwind nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #4 = { cold nonlazybind uwtable "probe-stack"="inline-asm" "target-cpu"="x86-64" }
 attributes #5 = { mustprogress nocallback nofree nosync nounwind willreturn memory(argmem: readwrite) }
-attributes #6 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
+attributes #6 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: write) }
+attributes #7 = { nocallback nofree nosync nounwind willreturn memory(inaccessiblemem: readwrite) }
 
 !llvm.module.flags = !{!0, !1, !2}
 !llvm.ident = !{!3}
diff --git a/bench/unicode-normalization-rs/optimized/kwscsepwptyv51i.ll b/bench/unicode-normalization-rs/optimized/kwscsepwptyv51i.ll
index 3cff855109e..84c8fcd8526 100644
--- a/bench/unicode-normalization-rs/optimized/kwscsepwptyv51i.ll
+++ b/bench/unicode-normalization-rs/optimized/kwscsepwptyv51i.ll
@@ -46,6 +46,7 @@ define hidden void @_ZN4core4iter6traits8iterator8Iterator4fold17h174e2c69d9c944
   br i1 %11, label %12, label %"_ZN4core6option15Option$LT$T$GT$7or_else17hf3db5b66814f085bE.exit.thread.i"
 
 12:                                               ; preds = %"_ZN4core4iter6traits8iterator8Iterator8for_each4call28_$u7b$$u7b$closure$u7d$$u7d$17ha6cebfed4dedef8bE.exit"
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !8)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !11)
   %13 = icmp eq ptr %10, %5
@@ -65,6 +66,7 @@ define hidden void @_ZN4core4iter6traits8iterator8Iterator4fold17h174e2c69d9c944
   tail call void @llvm.assume(i1 %20)
   %21 = getelementptr inbounds nuw i8, ptr %10, i64 2
   store ptr %21, ptr %0, align 8, !alias.scope !18
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %15) ]
   %22 = load i8, ptr %15, align 1, !noalias !17, !noundef !7
   %23 = shl nuw nsw i32 %19, 6
   %24 = and i8 %22, 63
@@ -82,6 +84,7 @@ define hidden void @_ZN4core4iter6traits8iterator8Iterator4fold17h174e2c69d9c944
   tail call void @llvm.assume(i1 %29)
   %30 = getelementptr inbounds nuw i8, ptr %10, i64 3
   store ptr %30, ptr %0, align 8, !alias.scope !21
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %21) ]
   %31 = load i8, ptr %21, align 1, !noalias !17, !noundef !7
   %32 = shl nuw nsw i32 %25, 6
   %33 = and i8 %31, 63
@@ -97,6 +100,7 @@ define hidden void @_ZN4core4iter6traits8iterator8Iterator4fold17h174e2c69d9c944
   tail call void @llvm.assume(i1 %39)
   %40 = getelementptr inbounds nuw i8, ptr %10, i64 4
   store ptr %40, ptr %0, align 8, !alias.scope !24
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %30) ]
   %41 = load i8, ptr %30, align 1, !noalias !17, !noundef !7
   %42 = shl nuw nsw i32 %19, 18
   %43 = and i32 %42, 1835008
@@ -229,8 +233,9 @@ _ZN21unicode_normalization11stream_safe20classify_nonstarters17hdc3d352c4dbebd42
 .thread15:                                        ; preds = %_ZN21unicode_normalization11stream_safe20classify_nonstarters17hdc3d352c4dbebd42E.exit.i
   store i64 0, ptr %6, align 8, !alias.scope !4
   store i32 %.0.i1014.i, ptr %3, align 8, !alias.scope !4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %.sroa.0.i.i.i)
-  store i32 0, ptr %.sroa.0.i.i.i, align 4, !noalias !39
+  store i32 0, ptr %.sroa.0, align 4, !noalias !39
   br label %96
 
 "_ZN114_$LT$unicode_normalization..stream_safe..StreamSafe$LT$I$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17hc484d1e554794a18E.exit": ; preds = %_ZN21unicode_normalization11stream_safe20classify_nonstarters17hdc3d352c4dbebd42E.exit.i
@@ -242,6 +247,7 @@ _ZN21unicode_normalization11stream_safe20classify_nonstarters17hdc3d352c4dbebd42
   br i1 %.not, label %"_ZN114_$LT$unicode_normalization..stream_safe..StreamSafe$LT$I$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17hc484d1e554794a18E.exit.thread", label %90
 
 90:                                               ; preds = %"_ZN114_$LT$unicode_normalization..stream_safe..StreamSafe$LT$I$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4next17hc484d1e554794a18E.exit"
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !39)
   %91 = icmp samesign ult i32 %.0.i1014.i, 128
   br i1 %91, label %.critedge.i.i.i, label %92
@@ -257,9 +263,9 @@ _ZN21unicode_normalization11stream_safe20classify_nonstarters17hdc3d352c4dbebd42
   br i1 %95, label %104, label %115
 
 96:                                               ; preds = %.thread15, %92
-  %97 = phi i64 [ 0, %.thread15 ], [ %storemerge.i, %92 ]
-  %.0.i1014.i25 = phi i32 [ %.0.i1014.i, %.thread15 ], [ 1114112, %92 ]
-  %.0.i121417 = phi i32 [ 847, %.thread15 ], [ %.0.i1014.i, %92 ]
+  %97 = phi i64 [ 0, %.thread18 ], [ %storemerge.i, %92 ]
+  %.0.i1014.i25 = phi i32 [ %.0.i1014.i, %.thread18 ], [ 1114112, %92 ]
+  %.0.i121417 = phi i32 [ 847, %.thread18 ], [ %.0.i1014.i, %92 ]
   %98 = lshr i32 %.0.i121417, 6
   %99 = trunc nuw nsw i32 %98 to i8
   %100 = or disjoint i8 %99, -64
diff --git a/bench/velox/optimized/SIMDJsonExtractor.ll b/bench/velox/optimized/SIMDJsonExtractor.ll
index 751734d61f2..36e19659c97 100644
--- a/bench/velox/optimized/SIMDJsonExtractor.ll
+++ b/bench/velox/optimized/SIMDJsonExtractor.ll
@@ -753,7 +753,12 @@ if.end.i76:                                       ; preds = %if.then.i94, %if.en
   %arrayidx.i174 = getelementptr inbounds nuw i8, ptr %8, i64 %idxprom.i173
   %15 = load i8, ptr %arrayidx.i174, align 1, !noalias !17
   %cmp.i106 = icmp eq i8 %15, 125
-  br i1 %cmp.i106, label %if.end.i68, label %if.end.i32.lr.ph
+  br i1 %cmp.i106, label %if.end.i68, label %if.end.i68.thread
+
+if.end.i68.thread:                                ; preds = %if.end.i76
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %11) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %11) ]
+  br label %if.end.i32.lr.ph
 
 if.end.i68:                                       ; preds = %if.end.i76
   %_position.i249 = getelementptr inbounds nuw i8, ptr %11, i64 8
@@ -772,14 +777,16 @@ if.end.i68:                                       ; preds = %if.end.i76
   %ref.tmp3.i.sroa.0.sroa.4.0.copyload.pre = load ptr, ptr %_start_position.i, align 8, !noalias !17
   %_depth.i.i311.phi.trans.insert = getelementptr inbounds nuw i8, ptr %ref.tmp3.i.sroa.0.sroa.0.0.copyload.pre, i64 36
   %.pre468 = load i32, ptr %_depth.i.i311.phi.trans.insert, align 4
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %ref.tmp3.i.sroa.0.sroa.0.0.copyload.pre) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %ref.tmp3.i.sroa.0.sroa.0.0.copyload.pre) ]
   %cmp.i313.not456 = icmp slt i32 %.pre468, %ref.tmp3.i.sroa.0.sroa.2.0.copyload.pre
   br i1 %cmp.i313.not456, label %return, label %if.end.i32.lr.ph
 
-if.end.i32.lr.ph:                                 ; preds = %if.end.i76, %if.end.i68
-  %ref.tmp3.i.sroa.0.sroa.0.0.copyload487 = phi ptr [ %ref.tmp3.i.sroa.0.sroa.0.0.copyload.pre, %if.end.i68 ], [ %11, %if.end.i76 ]
-  %ref.tmp3.i.sroa.0.sroa.2.0.copyload486 = phi i32 [ %ref.tmp3.i.sroa.0.sroa.2.0.copyload.pre, %if.end.i68 ], [ %12, %if.end.i76 ]
-  %ref.tmp3.i.sroa.0.sroa.4.0.copyload485 = phi ptr [ %ref.tmp3.i.sroa.0.sroa.4.0.copyload.pre, %if.end.i68 ], [ %9, %if.end.i76 ]
-  %19 = phi i32 [ %.pre468, %if.end.i68 ], [ %12, %if.end.i76 ]
+if.end.i32.lr.ph:                                 ; preds = %if.end.i68.thread, %if.end.i68
+  %ref.tmp3.i.sroa.0.sroa.0.0.copyload487 = phi ptr [ %11, %if.end.i68.thread ], [ %ref.tmp3.i.sroa.0.sroa.0.0.copyload.pre, %if.end.i68 ]
+  %ref.tmp3.i.sroa.0.sroa.2.0.copyload486 = phi i32 [ %12, %if.end.i68.thread ], [ %ref.tmp3.i.sroa.0.sroa.2.0.copyload.pre, %if.end.i68 ]
+  %ref.tmp3.i.sroa.0.sroa.4.0.copyload485 = phi ptr [ %9, %if.end.i68.thread ], [ %ref.tmp3.i.sroa.0.sroa.4.0.copyload.pre, %if.end.i68 ]
+  %19 = phi i32 [ %12, %if.end.i68.thread ], [ %.pre468, %if.end.i68 ]
   %_depth.i.i311488 = getelementptr inbounds nuw i8, ptr %ref.tmp3.i.sroa.0.sroa.0.0.copyload487, i64 36
   %error.i353 = getelementptr inbounds nuw i8, ptr %ref.tmp3.i.sroa.0.sroa.0.0.copyload487, i64 32
   %_position.i262 = getelementptr inbounds nuw i8, ptr %ref.tmp3.i.sroa.0.sroa.0.0.copyload487, i64 8
@@ -843,6 +850,7 @@ if.end.i39:                                       ; preds = %if.end.i365
   store i32 %add.i427, ptr %_depth.i.i311488, align 4, !noalias !23
   %cmp.i278 = icmp ugt ptr %incdec.ptr.i.i419, %ref.tmp3.i.sroa.0.sroa.4.0.copyload485
   tail call void @llvm.assume(i1 %cmp.i278), !noalias !26
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %incdec.ptr.i404) ]
   %28 = load ptr, ptr %_string_buf_loc.i, align 8, !noalias !31
   %29 = load <4 x i64>, ptr %incdec.ptr.i404, align 1
   store <4 x i64> %29, ptr %28, align 1
@@ -1396,8 +1404,8 @@ _ZN5folly5tryToIiEENSt9enable_ifIXntsr3std7is_sameINS_5RangeIPKcEET_EE5valueENS_
 
 _ZNR5folly8ExpectedIiNS_14ConversionCodeEE5valueEv.exit: ; preds = %_ZN5folly5tryToIiEENSt9enable_ifIXntsr3std7is_sameINS_5RangeIPKcEET_EE5valueENS_8ExpectedIS6_NSt16remove_referenceIDTclsr6detailE11parseToWraptlS5_Eclsr3stdE7declvalIRS6_EEEEE4type10error_typeEEEE4typeES5_.exit
   %conv = ashr i64 %retval.sroa.3.0.insert.insert.i.i.i.i, 32
-  %cmp.i.i172 = icmp ne ptr %ref.tmp3.i.sroa.0.sroa.0.0.copyload, null
-  call void @llvm.assume(i1 %cmp.i.i172)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %ref.tmp3.i.sroa.0.sroa.0.0.copyload) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %ref.tmp3.i.sroa.0.sroa.0.0.copyload) ]
   %_depth.i.i.i217 = getelementptr inbounds nuw i8, ptr %ref.tmp3.i.sroa.0.sroa.0.0.copyload, i64 36
   %22 = load i32, ptr %_depth.i.i.i217, align 4
   %cmp.i.i219.not187 = icmp slt i32 %22, %ref.tmp3.i.sroa.0.sroa.2.0.copyload
diff --git a/bench/wasmi-rs/optimized/4akm4xgsbb4qd7scd166b4xk0.ll b/bench/wasmi-rs/optimized/4akm4xgsbb4qd7scd166b4xk0.ll
index 558b7b0814a..b24bcdd0f57 100644
--- a/bench/wasmi-rs/optimized/4akm4xgsbb4qd7scd166b4xk0.ll
+++ b/bench/wasmi-rs/optimized/4akm4xgsbb4qd7scd166b4xk0.ll
@@ -452,6 +452,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %3 = alloca [8 x i8], align 8
   %4 = load ptr, ptr %0, align 8, !nonnull !9, !align !10, !noundef !9
   %.val = load ptr, ptr %4, align 8, !nonnull !9, !align !10, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = getelementptr inbounds nuw i8, ptr %.val, i64 40
   %6 = getelementptr inbounds nuw i8, ptr %.val, i64 88
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !34
@@ -615,6 +616,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %.val = load ptr, ptr %4, align 8, !nonnull !9, !align !49, !noundef !9
   %5 = getelementptr i8, ptr %4, i64 8
   %.val1 = load i64, ptr %5, align 8, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !80
   call void @_ZN4core3fmt9Formatter10debug_list17h6d35c138e0d8eb64E(ptr noalias noundef nonnull sret([16 x i8]) align 8 captures(none) dereferenceable(16) %3, ptr noalias noundef nonnull align 8 dereferenceable(24) %1), !noalias !86
   %6 = getelementptr inbounds nuw i8, ptr %.val, i64 %.val1
@@ -660,6 +662,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %3 = alloca [8 x i8], align 8
   %4 = load ptr, ptr %0, align 8, !nonnull !9, !align !10, !noundef !9
   %.val = load ptr, ptr %4, align 8, !nonnull !9, !align !10, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = getelementptr inbounds nuw i8, ptr %.val, i64 16
   %6 = getelementptr inbounds nuw i8, ptr %.val, i64 48
   %7 = getelementptr inbounds nuw i8, ptr %.val, i64 40
@@ -721,6 +724,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %.val = load ptr, ptr %3, align 8, !nonnull !9, !align !10, !noundef !9
   %4 = getelementptr i8, ptr %3, i64 8
   %.val1 = load i64, ptr %4, align 8, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = tail call noundef zeroext i1 @"_ZN48_$LT$$u5b$T$u5d$$u20$as$u20$core..fmt..Debug$GT$3fmt17h6a6f7f12d816ee5bE"(ptr noalias noundef nonnull readonly align 8 %.val, i64 noundef %.val1, ptr noalias noundef nonnull align 8 dereferenceable(24) %1)
   ret i1 %5
 }
@@ -790,6 +794,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %3 = alloca [8 x i8], align 8
   %4 = load ptr, ptr %0, align 8, !nonnull !9, !align !10, !noundef !9
   %.val = load ptr, ptr %4, align 8, !nonnull !9, !align !10, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = getelementptr inbounds nuw i8, ptr %.val, i64 96
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !116
   %6 = getelementptr inbounds nuw i8, ptr %.val, i64 48
@@ -850,6 +855,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %21 = alloca [8 x i8], align 8
   %22 = load ptr, ptr %0, align 8, !nonnull !9, !align !10, !noundef !9
   %.val = load ptr, ptr %22, align 8, !nonnull !9, !align !10, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !126)
   %23 = load i8, ptr %.val, align 8, !range !129, !alias.scope !126, !noalias !130, !noundef !9
   %24 = add nsw i8 %23, -6
@@ -1116,6 +1122,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %3 = alloca [8 x i8], align 8
   %4 = load ptr, ptr %0, align 8, !nonnull !9, !align !10, !noundef !9
   %.val = load ptr, ptr %4, align 8, !nonnull !9, !align !10, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = getelementptr inbounds nuw i8, ptr %.val, i64 40
   %6 = getelementptr inbounds nuw i8, ptr %.val, i64 88
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !149
@@ -1220,6 +1227,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %3 = alloca [8 x i8], align 8
   %4 = load ptr, ptr %0, align 8, !nonnull !9, !align !10, !noundef !9
   %.val = load ptr, ptr %4, align 8, !nonnull !9, !align !10, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = getelementptr inbounds nuw i8, ptr %.val, i64 72
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !171
   store ptr %.val, ptr %3, align 8, !noalias !171
@@ -1283,6 +1291,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %5 = alloca [8 x i8], align 8
   %6 = load ptr, ptr %0, align 8, !nonnull !9, !align !10, !noundef !9
   %.val = load ptr, ptr %6, align 8, !nonnull !9, !align !10, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !185)
   %7 = load i64, ptr %.val, align 8, !range !188, !alias.scope !185, !noalias !189, !noundef !9
   %8 = xor i64 %7, -9223372036854775808
@@ -1431,6 +1440,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %3 = alloca [8 x i8], align 8
   %4 = load ptr, ptr %0, align 8, !nonnull !9, !align !10, !noundef !9
   %.val = load ptr, ptr %4, align 8, !nonnull !9, !align !10, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = getelementptr inbounds nuw i8, ptr %.val, i64 96
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !217
   %6 = getelementptr inbounds nuw i8, ptr %.val, i64 48
@@ -1488,6 +1498,8 @@ define internal noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug
   %.val = load ptr, ptr %3, align 8, !nonnull !9, !align !49, !noundef !9
   %4 = getelementptr i8, ptr %3, i64 8
   %.val1 = load ptr, ptr %4, align 8, !nonnull !9, !align !10, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1) ]
   %5 = getelementptr inbounds nuw i8, ptr %.val1, i64 32
   %6 = load ptr, ptr %5, align 8, !invariant.load !9, !noalias !233, !nonnull !9
   %7 = tail call noundef zeroext i1 %6(ptr noundef nonnull align 1 %.val, ptr noalias noundef nonnull align 8 dereferenceable(24) %1)
@@ -1500,6 +1512,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %.val = load ptr, ptr %3, align 8, !nonnull !9, !align !10, !noundef !9
   %4 = getelementptr i8, ptr %3, i64 8
   %.val1 = load i64, ptr %4, align 8, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = tail call noundef zeroext i1 @"_ZN48_$LT$$u5b$T$u5d$$u20$as$u20$core..fmt..Debug$GT$3fmt17ha7a0a6c5994e02d4E"(ptr noalias noundef nonnull readonly align 8 %.val, i64 noundef %.val1, ptr noalias noundef nonnull align 8 dereferenceable(24) %1)
   ret i1 %5
 }
@@ -1862,9 +1875,11 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h5f2ae8b6bed3ffa
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !241
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %4, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !241
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   %.val.i = load ptr, ptr %1, align 8, !noalias !244, !nonnull !9, !align !49, !noundef !9
   %10 = getelementptr inbounds nuw i8, ptr %1, i64 8
   %.val1.i = load i64, ptr %10, align 8, !noalias !244, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i) ]
   call fastcc void @"_ZN71_$LT$core..hash..sip..Hasher$LT$S$GT$$u20$as$u20$core..hash..Hasher$GT$5write17he62b249348ac77c6E"(ptr noalias noundef nonnull align 8 dereferenceable(72) %4, ptr noalias noundef nonnull readonly align 1 %.val.i, i64 noundef %.val1.i)
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !247
   store i8 -1, ptr %3, align 1, !noalias !247
@@ -1966,6 +1981,7 @@ define hidden noundef i64 @_ZN4core4hash11BuildHasher8hash_one17h612c5de4e2be311
   store i64 %.val2, ptr %.sroa.812.0..sroa_idx.i, align 8, !alias.scope !265
   %.sroa.913.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %5, i64 48
   call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(24) %.sroa.913.0..sroa_idx.i, i8 0, i64 24, i1 false), !alias.scope !265
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %1) ]
   call fastcc void @"_ZN71_$LT$core..hash..sip..Hasher$LT$S$GT$$u20$as$u20$core..hash..Hasher$GT$5write17he62b249348ac77c6E"(ptr noalias noundef nonnull align 8 dereferenceable(72) %5, ptr noalias noundef nonnull readonly align 1 %1, i64 noundef %2)
   call void @llvm.lifetime.start.p0(ptr nonnull %4), !noalias !268
   store i8 -1, ptr %4, align 1, !noalias !268
@@ -2105,6 +2121,7 @@ define hidden noundef zeroext i1 @"_ZN52_$LT$Q$u20$as$u20$hashbrown..Equivalent$
   %.val = load ptr, ptr %2, align 8, !nonnull !9, !align !49, !noundef !9
   %4 = getelementptr inbounds nuw i8, ptr %2, i64 8
   %.val3 = load i64, ptr %4, align 8, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = tail call noundef zeroext i1 @"_ZN73_$LT$$u5b$A$u5d$$u20$as$u20$core..slice..cmp..SlicePartialEq$LT$B$GT$$GT$5equal17h214329bcf264de1fE"(ptr noalias noundef nonnull readonly align 1 %0, i64 noundef %1, ptr noalias noundef nonnull readonly align 1 %.val, i64 noundef %.val3)
   ret i1 %5
 }
@@ -2117,6 +2134,8 @@ define hidden noundef zeroext i1 @"_ZN52_$LT$Q$u20$as$u20$hashbrown..Equivalent$
   %.val3 = load ptr, ptr %1, align 8, !nonnull !9, !align !49, !noundef !9
   %4 = getelementptr inbounds nuw i8, ptr %1, i64 8
   %.val4 = load i64, ptr %4, align 8, !noundef !9
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val3) ]
   %5 = tail call noundef zeroext i1 @"_ZN73_$LT$$u5b$A$u5d$$u20$as$u20$core..slice..cmp..SlicePartialEq$LT$B$GT$$GT$5equal17h214329bcf264de1fE"(ptr noalias noundef nonnull readonly align 1 %.val, i64 noundef %.val2, ptr noalias noundef nonnull readonly align 1 %.val3, i64 noundef %.val4)
   ret i1 %5
 }
diff --git a/bench/wasmi-rs/optimized/719lozgs6r4m6dzt5mpwrqz2n.ll b/bench/wasmi-rs/optimized/719lozgs6r4m6dzt5mpwrqz2n.ll
index bc221bcedb8..71dee17f60f 100644
--- a/bench/wasmi-rs/optimized/719lozgs6r4m6dzt5mpwrqz2n.ll
+++ b/bench/wasmi-rs/optimized/719lozgs6r4m6dzt5mpwrqz2n.ll
@@ -89,6 +89,8 @@ define internal noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug
   %.val = load ptr, ptr %3, align 8, !nonnull !3, !align !5, !noundef !3
   %4 = getelementptr i8, ptr %3, i64 8
   %.val1 = load ptr, ptr %4, align 8, !nonnull !3, !align !4, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val1) ]
   %5 = getelementptr inbounds nuw i8, ptr %.val1, i64 32
   %6 = load ptr, ptr %5, align 8, !invariant.load !3, !noalias !6, !nonnull !3
   %7 = tail call noundef zeroext i1 %6(ptr noundef nonnull align 1 %.val, ptr noalias noundef nonnull align 8 dereferenceable(24) %1)
@@ -111,6 +113,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %3 = alloca [8 x i8], align 8
   %4 = load ptr, ptr %0, align 8, !nonnull !3, !align !4, !noundef !3
   %.val = load ptr, ptr %4, align 8, !nonnull !3, !align !4, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = getelementptr inbounds nuw i8, ptr %.val, i64 40
   %6 = getelementptr inbounds nuw i8, ptr %.val, i64 88
   call void @llvm.lifetime.start.p0(ptr nonnull %3), !noalias !14
@@ -128,6 +131,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %5 = alloca [8 x i8], align 8
   %6 = load ptr, ptr %0, align 8, !nonnull !3, !align !4, !noundef !3
   %.val = load ptr, ptr %6, align 8, !nonnull !3, !align !4, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !20)
   %7 = load i64, ptr %.val, align 8, !range !23, !alias.scope !20, !noalias !24, !noundef !3
   %8 = xor i64 %7, -9223372036854775808
@@ -189,6 +193,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %21 = alloca [8 x i8], align 8
   %22 = load ptr, ptr %0, align 8, !nonnull !3, !align !4, !noundef !3
   %.val = load ptr, ptr %22, align 8, !nonnull !3, !align !4, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !29)
   %23 = load i8, ptr %.val, align 8, !range !32, !alias.scope !29, !noalias !33, !noundef !3
   %24 = add nsw i8 %23, -6
@@ -382,6 +387,7 @@ define hidden noundef zeroext i1 @"_ZN42_$LT$$RF$T$u20$as$u20$core..fmt..Debug$G
   %3 = alloca [8 x i8], align 8
   %4 = load ptr, ptr %0, align 8, !nonnull !3, !align !4, !noundef !3
   %.val = load ptr, ptr %4, align 8, !nonnull !3, !align !4, !noundef !3
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val) ]
   %5 = getelementptr inbounds nuw i8, ptr %.val, i64 16
   %6 = getelementptr inbounds nuw i8, ptr %.val, i64 48
   %7 = getelementptr inbounds nuw i8, ptr %.val, i64 40
diff --git a/bench/wasmi-rs/optimized/a4jeuqdorkqtqnluubwo07hsf.ll b/bench/wasmi-rs/optimized/a4jeuqdorkqtqnluubwo07hsf.ll
index fdd39918516..ac03d7cd465 100644
--- a/bench/wasmi-rs/optimized/a4jeuqdorkqtqnluubwo07hsf.ll
+++ b/bench/wasmi-rs/optimized/a4jeuqdorkqtqnluubwo07hsf.ll
@@ -184,6 +184,7 @@ define void @_ZN10wasmi_fuzz12crash_inputs21generate_crash_inputs17h3cc47bdd2293
   %.sroa.4.0..sroa_idx.i = getelementptr inbounds nuw i8, ptr %36, i64 32
   store i64 0, ptr %.sroa.4.0..sroa_idx.i, align 8, !alias.scope !7
   tail call void @llvm.experimental.noalias.scope.decl(metadata !10)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %3) ]
   tail call void @llvm.experimental.noalias.scope.decl(metadata !13)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !16)
   tail call void @llvm.experimental.noalias.scope.decl(metadata !19)
@@ -327,13 +328,14 @@ define void @_ZN10wasmi_fuzz12crash_inputs21generate_crash_inputs17h3cc47bdd2293
   %90 = add nuw i64 %89, 1
   store i64 %90, ptr %83, align 8, !alias.scope !120, !noalias !123
   %91 = call { ptr, i64 } @"_ZN101_$LT$core..slice..iter..ChunksExactMut$LT$T$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$24__iterator_get_unchecked17he718173d41498862E"(ptr noalias noundef nonnull align 8 dereferenceable(80) %17, i64 noundef %89), !noalias !125
+  %.val.i.i.i.i.i = load ptr, ptr %88, align 8, !alias.scope !120, !noalias !123, !nonnull !6, !noundef !6
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %.val.i.i.i.i.i) ]
   %92 = extractvalue { ptr, i64 } %91, 0
   %.not.i.i.i.i = icmp eq ptr %92, null
   br i1 %.not.i.i.i.i, label %_ZN6digest11FixedOutput14finalize_fixed17hadcb9a5976a3bd9aE.exit, label %93
 
 93:                                               ; preds = %"_ZN111_$LT$core..iter..adapters..zip..Zip$LT$A$C$B$GT$$u20$as$u20$core..iter..adapters..zip..ZipImpl$LT$A$C$B$GT$$GT$4next17h911bd087de725c8aE.exit.i.i.i.i"
   %94 = extractvalue { ptr, i64 } %91, 1
-  %.val.i.i.i.i.i = load ptr, ptr %88, align 8, !alias.scope !120, !noalias !123, !nonnull !6, !noundef !6
   %95 = getelementptr inbounds nuw i32, ptr %.val.i.i.i.i.i, i64 %89
   %96 = load i32, ptr %95, align 4, !noalias !119, !noundef !6
   call void @llvm.experimental.noalias.scope.decl(metadata !126)
diff --git a/bench/wasmi-rs/optimized/alstpbhsjp4ox5ltqsedewni0.ll b/bench/wasmi-rs/optimized/alstpbhsjp4ox5ltqsedewni0.ll
index 9cce2add207..18820bf27c1 100644
--- a/bench/wasmi-rs/optimized/alstpbhsjp4ox5ltqsedewni0.ll
+++ b/bench/wasmi-rs/optimized/alstpbhsjp4ox5ltqsedewni0.ll
@@ -74,6 +74,7 @@ define hidden void @"_ZN5alloc3vec16Vec$LT$T$C$A$GT$14extend_trusted17h57c4855b1
 
 "_ZN106_$LT$core..iter..sources..repeat_n..RepeatN$LT$A$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17h7ee2b52b5a88c079E.exit.i": ; preds = %.preheader._crit_edge.i.i.i, %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h00ef68c59443dc64E.exit"
   %.val5.i.i.i = phi i64 [ %20, %.preheader._crit_edge.i.i.i ], [ %12, %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h00ef68c59443dc64E.exit" ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
   store i64 %.val5.i.i.i, ptr %6, align 8, !noalias !37
   call void @"_ZN4core3ptr98drop_in_place$LT$core..iter..sources..repeat_n..RepeatN$LT$wasmi_core..untyped..UntypedVal$GT$$GT$17hb7cd976adf301b29E"(ptr noalias noundef nonnull align 8 dereferenceable(24) %4)
   call void @llvm.lifetime.end.p0(ptr nonnull %4)
@@ -148,6 +149,7 @@ define hidden void @"_ZN5alloc3vec16Vec$LT$T$C$A$GT$14extend_trusted17h7e846f384
 
 "_ZN106_$LT$core..iter..sources..repeat_n..RepeatN$LT$A$GT$$u20$as$u20$core..iter..traits..iterator..Iterator$GT$4fold17hc36828d342f3e299E.exit.i": ; preds = %.preheader._crit_edge.i.i.i, %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h09f646a5a3727c7aE.exit"
   %.val5.i.i.i = phi i64 [ %22, %.preheader._crit_edge.i.i.i ], [ %14, %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h09f646a5a3727c7aE.exit" ]
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %8) ]
   store i64 %.val5.i.i.i, ptr %8, align 8, !noalias !66
   call void @"_ZN4core3ptr69drop_in_place$LT$core..iter..sources..repeat_n..RepeatN$LT$u8$GT$$GT$17hb2b4240403592ef8E"(ptr noalias noundef nonnull align 8 dereferenceable(16) %5)
   call void @llvm.lifetime.end.p0(ptr nonnull %5), !noalias !41
@@ -212,7 +214,8 @@ define hidden void @"_ZN5alloc3vec16Vec$LT$T$C$A$GT$6resize17hb6f4580267b547cbE"
   %24 = getelementptr inbounds nuw i8, ptr %.sroa.0.0.lcssa18.i, i64 8
   store i64 %3, ptr %24, align 8
   %25 = add i64 %storemerge.lcssa17.i, 1
-  br label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$11extend_with17h554eacf8da0c13dcE.exit"
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %6) ]
+  br label %29
 
 .lr.ph.i:                                         ; preds = %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h00ef68c59443dc64E.exit.i", %.lr.ph.i
   %.sroa.0.011.i = phi ptr [ %28, %.lr.ph.i ], [ %20, %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h00ef68c59443dc64E.exit.i" ]
@@ -226,7 +229,7 @@ define hidden void @"_ZN5alloc3vec16Vec$LT$T$C$A$GT$6resize17hb6f4580267b547cbE"
   br i1 %exitcond.not.i, label %._crit_edge.thread.i, label %.lr.ph.i
 
 "_ZN5alloc3vec16Vec$LT$T$C$A$GT$11extend_with17h554eacf8da0c13dcE.exit": ; preds = %5, %._crit_edge.i
-  %storemerge = phi i64 [ %1, %5 ], [ %25, %._crit_edge.i ]
+  %storemerge = phi i64 [ %25, %._crit_edge.i ], [ %1, %5 ]
   store i64 %storemerge, ptr %6, align 8
   ret void
 }
@@ -274,10 +277,11 @@ define hidden void @"_ZN5alloc3vec16Vec$LT$T$C$A$GT$6resize17he68b3cb74bd146a2E"
   %storemerge.lcssa16.i = phi i64 [ %22, %._crit_edge.thread.i ], [ %15, %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$7reserve17h09f646a5a3727c7aE.exit.i" ]
   store i8 %2, ptr %.sroa.0.0.lcssa17.i, align 1
   %23 = add i64 %storemerge.lcssa16.i, 1
-  br label %"_ZN5alloc3vec16Vec$LT$T$C$A$GT$11extend_with17hb35e3abaddc6f782E.exit"
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %5) ]
+  br label %24
 
 "_ZN5alloc3vec16Vec$LT$T$C$A$GT$11extend_with17hb35e3abaddc6f782E.exit": ; preds = %4, %._crit_edge.i
-  %storemerge = phi i64 [ %1, %4 ], [ %23, %._crit_edge.i ]
+  %storemerge = phi i64 [ %23, %._crit_edge.i ], [ %1, %4 ]
   store i64 %storemerge, ptr %5, align 8
   ret void
 }
diff --git a/bench/zstd/optimized/xxhash.ll b/bench/zstd/optimized/xxhash.ll
index 801819442a5..2619edfde16 100644
--- a/bench/zstd/optimized/xxhash.ll
+++ b/bench/zstd/optimized/xxhash.ll
@@ -158,9 +158,8 @@ define void @ZSTD_XXH32_copyState(ptr noundef writeonly captures(none) initializ
 }
 
 ; Function Attrs: mustprogress nofree norecurse nosync nounwind willreturn memory(argmem: write, inaccessiblemem: write) uwtable
-define noundef i32 @ZSTD_XXH32_reset(ptr noundef writeonly captures(address_is_null) %0, i32 noundef %1) local_unnamed_addr #5 {
-  %3 = icmp ne ptr %0, null
-  tail call void @llvm.assume(i1 %3)
+define noundef i32 @ZSTD_XXH32_reset(ptr noundef writeonly captures(none) %0, i32 noundef %1) local_unnamed_addr #5 {
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   tail call void @llvm.memset.p0.i64(ptr noundef nonnull align 4 dereferenceable(48) %0, i8 0, i64 48, i1 false)
   %4 = add i32 %1, 606290984
   %5 = getelementptr inbounds nuw i8, ptr %0, i64 8
@@ -649,8 +648,7 @@ define void @ZSTD_XXH64_copyState(ptr noundef writeonly captures(none) initializ
 
 ; Function Attrs: mustprogress nofree norecurse nosync nounwind willreturn memory(argmem: write, inaccessiblemem: write) uwtable
 define noundef i32 @ZSTD_XXH64_reset(ptr noundef writeonly captures(none) %0, i64 noundef %1) local_unnamed_addr #5 {
-  %3 = icmp ne ptr %0, null
-  tail call void @llvm.assume(i1 %3)
+  call void @llvm.assume(i1 true) [ "nonnull"(ptr %0) ]
   tail call void @llvm.memset.p0.i64(ptr noundef nonnull align 8 dereferenceable(88) %0, i8 0, i64 88, i1 false)
   %4 = add i64 %1, 6983438078262162902
   %5 = getelementptr inbounds nuw i8, ptr %0, i64 8
diff --git a/scripts/setup_pre_commit_patch.sh b/scripts/setup_pre_commit_patch.sh
index c8d0fce0bf7..6d1c5ff92d5 100755
--- a/scripts/setup_pre_commit_patch.sh
+++ b/scripts/setup_pre_commit_patch.sh
@@ -2,7 +2,7 @@
 set -euo pipefail
 shopt -s inherit_errexit
 
-export GITHUB_PATCH_ID="<user_name>/llvm-project/commit/<commit_hash>"
+export GITHUB_PATCH_ID=llvm/llvm-project/pull/169923
 export COMPTIME_MODE=0
 export STAT_MODE=0
 export STAT_NAME=""