diff --git a/src/System.Windows.Forms/src/System/Windows/Forms/ComboBox.cs b/src/System.Windows.Forms/src/System/Windows/Forms/ComboBox.cs
index 7da0309d6ea..c8bede8ac02 100644
--- a/src/System.Windows.Forms/src/System/Windows/Forms/ComboBox.cs
+++ b/src/System.Windows.Forms/src/System/Windows/Forms/ComboBox.cs
@@ -3058,6 +3058,11 @@ protected virtual void OnDropDownClosed(EventArgs e)
                     AccessibilityObject.RaiseAutomationEvent(UiaCore.UIA.AutomationFocusChangedEventId);
                 }
 
+                // Some accessibility tools (e.g., NVDA) could recognize ComboBox as IAccessible object
+                // and ignore UIA focus change event. For such cases we need to additionaly raise MSAA focus event.
+                // childID = CHILDID_SELF - 1 (the -1 will resolve to CHILDID_SELF when we call NotifyWinEvent)
+                AccessibilityNotifyClients(AccessibleEvents.Focus, childID: -1);
+
                 // Notify Collapsed/expanded property change.
                 AccessibilityObject.RaiseAutomationPropertyChangedEvent(
                     UiaCore.UIA.ExpandCollapseExpandCollapseStatePropertyId,