diff --git a/src/coreclr/jit/emitarm.cpp b/src/coreclr/jit/emitarm.cpp
index b526eafa53e2e3..c1dc431c937287 100644
--- a/src/coreclr/jit/emitarm.cpp
+++ b/src/coreclr/jit/emitarm.cpp
@@ -4848,6 +4848,7 @@ void emitter::emitIns_Call(EmitCallType          callType,
 
     dispIns(id);
     appendToCurIG(id);
+    emitLastMemBarrier = nullptr; // Cannot optimize away future memory barriers
 }
 
 /*****************************************************************************
diff --git a/src/coreclr/jit/emitarm64.cpp b/src/coreclr/jit/emitarm64.cpp
index 86e23282f11de3..f0428d222fc6c5 100644
--- a/src/coreclr/jit/emitarm64.cpp
+++ b/src/coreclr/jit/emitarm64.cpp
@@ -8908,6 +8908,7 @@ void emitter::emitIns_Call(EmitCallType          callType,
 
     dispIns(id);
     appendToCurIG(id);
+    emitLastMemBarrier = nullptr; // Cannot optimize away future memory barriers
 }
 
 /*****************************************************************************