diff --git a/src/coreclr/jit/emit.h b/src/coreclr/jit/emit.h
index 3c892ec072fd6e..94ded1df85fcdf 100644
--- a/src/coreclr/jit/emit.h
+++ b/src/coreclr/jit/emit.h
@@ -3930,6 +3930,19 @@ emitAttr emitter::emitGetBaseMemOpSize(instrDesc* id) const
             }
         }
 
+        case INS_psrlw:
+        case INS_psrld:
+        case INS_psrlq:
+        case INS_psraw:
+        case INS_psrad:
+        case INS_psllw:
+        case INS_pslld:
+        case INS_psllq:
+        {
+            // These always have 16-byte memory loads
+            return EA_16BYTE;
+        }
+
         case INS_vpmovdb:
         case INS_vpmovdw:
         case INS_vpmovqb:
diff --git a/src/coreclr/jit/emitxarch.cpp b/src/coreclr/jit/emitxarch.cpp
index 980d40a47ac318..ba599c9e465ad0 100644
--- a/src/coreclr/jit/emitxarch.cpp
+++ b/src/coreclr/jit/emitxarch.cpp
@@ -14098,11 +14098,11 @@ BYTE* emitter::emitOutputCV(BYTE* dst, instrDesc* id, code_t code, CnsVal* addc)
         {
             if (emitComp->compCodeOpt() == Compiler::SMALL_CODE)
             {
-                assert((reinterpret_cast<size_t>(addr) & 3) == 0);
+                assert(IS_ALIGNED(addr, 4));
             }
             else
             {
-                assert((reinterpret_cast<size_t>(addr) & (byteSize - 1)) == 0);
+                assert(IS_ALIGNED(addr, byteSize));
             }
         }
 #endif // DEBUG
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_91335/Runtime_91335.cs b/src/tests/JIT/Regression/JitBlue/Runtime_91335/Runtime_91335.cs
new file mode 100644
index 00000000000000..b89d6c71d78ce5
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_91335/Runtime_91335.cs
@@ -0,0 +1,90 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.aa
+
+// Found by Antigen
+
+using System;
+using System.Runtime.CompilerServices;
+using System.Runtime.Intrinsics;
+using System.Runtime.Intrinsics.X86;
+using Xunit;
+
+public class TestClass
+{
+    public struct S1
+    {
+        public Vector64<short> v64_short_0;
+        public ulong ulong_1;
+    }
+    public struct S2
+    {
+        public S1 s1_3;
+    }
+    static float s_float_13 = -1f;
+    static uint s_uint_16 = 1;
+    static ulong s_ulong_17 = 5;
+    static Vector128<short> s_v128_short_30 = Vector128.Create((short)2);
+    static Vector128<ushort> s_v128_ushort_31 = Vector128<ushort>.AllBitsSet;
+    static Vector128<int> s_v128_int_32 = Vector128.CreateScalar(2);
+    static Vector128<uint> s_v128_uint_33 = Vector128.Create((uint)1, 1, 1, 2);
+    static Vector128<long> s_v128_long_34 = Vector128.Create(-2, 2);
+    static Vector128<ulong> s_v128_ulong_35 = Vector128.Create((ulong)1);
+    static Vector128<float> s_v128_float_36 = Vector128.CreateScalar(0.1f);
+    static Vector128<double> s_v128_double_37 = Vector128.Create(1.0235294117647058, 2);
+    static Vector256<byte> s_v256_byte_38 = Vector256.CreateScalar((byte)5);
+    static Vector256<sbyte> s_v256_sbyte_39 = Vector256.Create(1, 0, -2, 2, 97, 97, -2, -5, 5, 5, -5, 1, 2, 1, 5, -2, 97, 2, 6, 2, 5, -5, 1, -2, 97, 2, 5, 5, 2, -2, 2, 5);
+    static Vector256<short> s_v256_short_40 = Vector256.CreateScalar((short)2);
+    static Vector256<ushort> s_v256_ushort_41 = Vector256.Create((ushort)97);
+    static Vector256<int> s_v256_int_42 = Vector256<int>.Zero;
+    static Vector256<uint> s_v256_uint_43 = Vector256.CreateScalar((uint)2);
+    static Vector256<long> s_v256_long_44 = Vector256.Create((long)-1);
+    static Vector256<ulong> s_v256_ulong_45 = Vector256<ulong>.Zero;
+    static Vector256<float> s_v256_float_46 = Vector256.CreateScalar(-4.969697f);
+    static Vector256<double> s_v256_double_47 = Vector256.Create(97.03448275862068);
+    static Vector512<byte> s_v512_byte_48 = Vector512.Create((byte)1);
+    static Vector512<sbyte> s_v512_sbyte_49 = Vector512.Create((sbyte)5);
+    static Vector512<short> s_v512_short_50 = Vector512<short>.AllBitsSet;
+    static Vector512<ushort> s_v512_ushort_51 = Vector512<ushort>.AllBitsSet;
+    static Vector512<int> s_v512_int_52 = Vector512<int>.AllBitsSet;
+    static Vector512<uint> s_v512_uint_53 = Vector512.CreateScalar((uint)5);
+    static Vector512<long> s_v512_long_54 = Vector512.CreateScalar((long)2);
+    static Vector512<ulong> s_v512_ulong_55 = Vector512<ulong>.Zero;
+    static S1 s_s1_61 = new S1();
+    static S2 s_s2_62 = new S2();
+    int int_69 = 2;
+    Vector128<sbyte> v128_sbyte_88 = Vector128<sbyte>.Zero;
+    Vector128<short> v128_short_89 = Vector128.CreateScalar((short)97);
+    Vector128<ushort> v128_ushort_90 = Vector128<ushort>.Zero;
+    Vector128<long> v128_long_93 = Vector128<long>.AllBitsSet;
+    Vector128<ulong> v128_ulong_94 = Vector128<ulong>.Zero;
+    Vector128<float> v128_float_95 = Vector128.Create(1.1153846f, 5f, 1.0232558f, 97.01786f);
+    Vector128<double> v128_double_96 = Vector128.Create(2.0375, 2);
+    Vector256<byte> v256_byte_97 = Vector256.CreateScalar((byte)5);
+    Vector256<short> v256_short_99 = Vector256.CreateScalar((short)5);
+    Vector256<ushort> v256_ushort_100 = Vector256<ushort>.Zero;
+    Vector256<int> v256_int_101 = Vector256.CreateScalar(97);
+    Vector256<uint> v256_uint_102 = Vector256.Create((uint)97);
+    Vector256<long> v256_long_103 = Vector256.CreateScalar((long)2);
+    Vector256<ulong> v256_ulong_104 = Vector256.CreateScalar((ulong)2);
+    Vector256<float> v256_float_105 = Vector256.Create(5.0869565f);
+    Vector256<double> v256_double_106 = Vector256.Create(-1.9411764705882353);
+    S1 s1_120 = new S1();
+    S2 s2_121 = new S2();
+
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    public Vector256<int> Method31()
+    {
+            byte byte_929 = 2;
+            return s_v256_int_42 += v256_int_101 | v256_int_101 ^ v256_int_101 | 
+                Vector256<int>.AllBitsSet & s_v256_int_42 ^ (s_v256_int_42 *= v256_int_101) - (v256_int_101 ^ Vector256<int>.Zero) & (v256_int_101 *= v256_int_101) - Avx2.ShiftRightLogical(v256_int_101, byte_929);
+    }
+
+    [Fact]
+    public static void TestEntryPoint()
+    {
+        if (Avx2.IsSupported)
+        {
+            new TestClass().Method31();
+        }
+    }
+}
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_91335/Runtime_91335.csproj b/src/tests/JIT/Regression/JitBlue/Runtime_91335/Runtime_91335.csproj
new file mode 100644
index 00000000000000..de6d5e08882e86
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_91335/Runtime_91335.csproj
@@ -0,0 +1,8 @@
+<Project Sdk="Microsoft.NET.Sdk">
+  <PropertyGroup>
+    <Optimize>True</Optimize>
+  </PropertyGroup>
+  <ItemGroup>
+    <Compile Include="$(MSBuildProjectName).cs" />
+  </ItemGroup>
+</Project>