diff --git a/eng/native/gen-buildsys.cmd b/eng/native/gen-buildsys.cmd
index 4a6bd162063682..d48996ac579dbe 100644
--- a/eng/native/gen-buildsys.cmd
+++ b/eng/native/gen-buildsys.cmd
@@ -2,26 +2,38 @@
 rem
 rem This file invokes cmake and generates the build system for windows.
 
-setlocal
+set __argCount=0
+for %%x in (%*) do set /A __argCount+=1
 
-set argC=0
-for %%x in (%*) do Set /A argC+=1
+if %__argCount% lss 4 goto :USAGE
+if %1=="/?" goto :USAGE
 
-if %argC% lss 4 GOTO :USAGE
-if %1=="/?" GOTO :USAGE
-
-setlocal enabledelayedexpansion
+set __Os=%5
 set "__repoRoot=%~dp0..\.."
 :: normalize
 for %%i in ("%__repoRoot%") do set "__repoRoot=%%~fi"
 
+:: Set up the EMSDK environment before setlocal so that it propagates to the caller.
+if /i "%__Os%" == "browser" (
+    if "%EMSDK_PATH%" == "" (
+        if not exist "%__repoRoot%\src\mono\browser\emsdk" (
+            echo Error: Should set EMSDK_PATH environment variable pointing to emsdk root.
+            exit /B 1
+        )
+        set EMSDK_QUIET=1 && call "%__repoRoot%\src\mono\browser\emsdk\emsdk_env"
+    ) else (
+        set EMSDK_QUIET=1 && call "%EMSDK_PATH%\emsdk_env"
+    )
+)
+
+setlocal enabledelayedexpansion
+
 set __SourceDir=%1
 set __IntermediatesDir=%2
 set __VSVersion=%3
 set __Arch=%4
-set __Os=%5
 set __CmakeGenerator=Visual Studio
-set __UseEmcmake=0
+set __ExtraCmakeParams=
 if /i "%__Ninja%" == "1" (
     set __CmakeGenerator=Ninja
 ) else (
@@ -38,22 +50,14 @@ if /i "%__Ninja%" == "1" (
 )
 
 if /i "%__Arch%" == "wasm" (
-
     if "%__Os%" == "" (
         echo Error: Please add target OS parameter
         exit /B 1
     )
     if /i "%__Os%" == "browser" (
-        if "%EMSDK_PATH%" == "" (
-            echo Error: Should set EMSDK_PATH environment variable pointing to emsdk root.
-            exit /B 1
-        )
-
         set CMakeToolPrefix=emcmake
     )
     if /i "%__Os%" == "wasi" (
-        set "__repoRoot=!__repoRoot:\=/!"
-        if not "!__repoRoot:~-1!" == "/" set "__repoRoot=!__repoRoot!/"
         if "%WASI_SDK_PATH%" == "" (
             if not exist "%__repoRoot%\src\mono\wasi\wasi-sdk" (
                 echo Error: Should set WASI_SDK_PATH environment variable pointing to WASI SDK root.
@@ -62,11 +66,8 @@ if /i "%__Arch%" == "wasm" (
 
             set "WASI_SDK_PATH=%__repoRoot%\src\mono\wasi\wasi-sdk"
         )
-        :: replace backslash with forward slash and append last slash
-        set "WASI_SDK_PATH=!WASI_SDK_PATH:\=/!"
-        if not "!WASI_SDK_PATH:~-1!" == "/" set "WASI_SDK_PATH=!WASI_SDK_PATH!/"
         set __CmakeGenerator=Ninja
-        set __ExtraCmakeParams=%__ExtraCmakeParams% -DCLR_CMAKE_TARGET_OS=wasi -DCLR_CMAKE_TARGET_ARCH=wasm "-DWASI_SDK_PREFIX=!WASI_SDK_PATH!" "-DCMAKE_TOOLCHAIN_FILE=!WASI_SDK_PATH!/share/cmake/wasi-sdk-p2.cmake" "-DCMAKE_SYSROOT=!WASI_SDK_PATH!share/wasi-sysroot" "-DCMAKE_CROSSCOMPILING_EMULATOR=node --experimental-wasm-bigint --experimental-wasi-unstable-preview1"
+        set __ExtraCmakeParams=%__ExtraCmakeParams% -DCLR_CMAKE_TARGET_OS=wasi "-DCMAKE_TOOLCHAIN_FILE=!WASI_SDK_PATH!/share/cmake/wasi-sdk-p2.cmake" "-DCMAKE_CROSSCOMPILING_EMULATOR=node --experimental-wasm-bigint --experimental-wasi-unstable-preview1"
     )
 ) else (
     set __ExtraCmakeParams=%__ExtraCmakeParams%  "-DCMAKE_SYSTEM_VERSION=10.0"
@@ -140,6 +141,6 @@ exit /B %errorlevel%
 :USAGE
   echo "Usage..."
   echo "gen-buildsys.cmd <path to top level CMakeLists.txt> <path to location for intermediate files> <VSVersion> <arch> <os>"
-  echo "Specify the path to the top level CMake file - <ProjectK>/src/NDP"
-  echo "Specify the VSVersion to be used - VS2017 or VS2019"
+  echo "Specify the path to the top level CMake file"
+  echo "Specify the VSVersion to be used, e. g. 17.0 for VS2022"
   EXIT /B 1
diff --git a/eng/native/gen-buildsys.sh b/eng/native/gen-buildsys.sh
index d4028cb9577ade..588a1cc6509799 100755
--- a/eng/native/gen-buildsys.sh
+++ b/eng/native/gen-buildsys.sh
@@ -97,9 +97,26 @@ fi
 cmake_extra_defines_wasm=()
 if [[ "$host_arch" == "wasm" ]]; then
     if [[ "$target_os" == "browser" ]]; then
+        if [[ -z "$EMSDK_PATH" ]]; then
+            if [[ -d "$reporoot"/src/mono/browser/emsdk/ ]]; then
+                export EMSDK_PATH="$reporoot"/src/mono/browser/emsdk/
+            else
+                echo "Error: You need to set the EMSDK_PATH environment variable pointing to the emscripten SDK root."
+                exit 1
+            fi
+        fi
+        export EMSDK_QUIET=1 && source "$EMSDK_PATH"/emsdk_env.sh
         cmake_command="emcmake $cmake_command"
     elif [[ "$target_os" == "wasi" ]]; then
-        cmake_extra_defines_wasm=("-DCLR_CMAKE_TARGET_OS=wasi" "-DCLR_CMAKE_TARGET_ARCH=wasm" "-DWASI_SDK_PREFIX=$WASI_SDK_PATH" "-DCMAKE_TOOLCHAIN_FILE=${WASI_SDK_PATH}/share/cmake/wasi-sdk-p2.cmake" "-DCMAKE_SYSROOT=${WASI_SDK_PATH}/share/wasi-sysroot" "-DCMAKE_CROSSCOMPILING_EMULATOR=node --experimental-wasm-bigint --experimental-wasi-unstable-preview1")
+        if [[ -z "$WASI_SDK_PATH" ]]; then
+            if [[ -d "$reporoot"/src/mono/wasi/wasi-sdk ]]; then
+                export WASI_SDK_PATH="$reporoot"/src/mono/wasi/wasi-sdk
+            else
+                echo "Error: You need to set the WASI_SDK_PATH environment variable pointing to the WASI SDK root."
+                exit 1
+            fi
+        fi
+        cmake_extra_defines_wasm=("-DCLR_CMAKE_TARGET_OS=wasi" "-DCMAKE_TOOLCHAIN_FILE=${WASI_SDK_PATH}/share/cmake/wasi-sdk-p2.cmake" "-DCMAKE_CROSSCOMPILING_EMULATOR=node --experimental-wasm-bigint --experimental-wasi-unstable-preview1")
     else
         echo "target_os was not specified"
         exit 1
diff --git a/src/coreclr/runtime.proj b/src/coreclr/runtime.proj
index efe3c5bf21cb4a..f18b970698520d 100644
--- a/src/coreclr/runtime.proj
+++ b/src/coreclr/runtime.proj
@@ -109,8 +109,6 @@
       <_CoreClrBuildScript Condition="$([MSBuild]::IsOsPlatform(Windows))">build-runtime.cmd</_CoreClrBuildScript>
       <_CoreClrBuildScript Condition="!$([MSBuild]::IsOsPlatform(Windows))">build-runtime.sh</_CoreClrBuildScript>
       <_CoreClrBuildCommand>&quot;$(MSBuildThisFileDirectory)$(_CoreClrBuildScript)&quot; @(_CoreClrBuildArg, ' ')</_CoreClrBuildCommand>
-      <_CoreClrBuildCommand Condition="'$(TargetsBrowser)' == 'true' and $([MSBuild]::IsOsPlatform(Windows))">call &quot;$([MSBuild]::NormalizePath('$(RepoRoot)src/mono/browser/emsdk', 'emsdk_env.cmd'))&quot; &amp;&amp; $(_CoreClrBuildCommand)</_CoreClrBuildCommand>
-      <_CoreClrBuildCommand Condition="'$(TargetsBrowser)' == 'true' and !$([MSBuild]::IsOsPlatform(Windows))">bash -c 'source &quot;$(RepoRoot)src/mono/browser/emsdk/emsdk_env.sh&quot; &amp;&amp; $(_CoreClrBuildCommand)'</_CoreClrBuildCommand>
     </PropertyGroup>
 
     <!-- Use IgnoreStandardErrorWarningFormat because Arcade sets WarnAsError and we want to avoid upgrading compiler warnings to errors in release branches -->
diff --git a/src/native/libs/CMakeLists.txt b/src/native/libs/CMakeLists.txt
index cf8b2b47fbd67b..4061e33130e8e0 100644
--- a/src/native/libs/CMakeLists.txt
+++ b/src/native/libs/CMakeLists.txt
@@ -119,10 +119,6 @@ if (CLR_CMAKE_TARGET_UNIX OR CLR_CMAKE_TARGET_BROWSER OR CLR_CMAKE_TARGET_WASI)
         add_subdirectory(System.IO.Ports.Native)
     endif ()
 
-    if (MONO_WASM_MT)
-        add_definitions(-DMONO_WASM_MT)
-    endif()
-
     if (CMAKE_C_COMPILER_ID MATCHES "Clang")
         add_compile_options(-Weverything)
         add_compile_options(-Wno-format-nonliteral)
diff --git a/src/native/libs/build-native.cmd b/src/native/libs/build-native.cmd
index 8dd3ad108dee0b..232b7d95b30d6d 100644
--- a/src/native/libs/build-native.cmd
+++ b/src/native/libs/build-native.cmd
@@ -19,7 +19,6 @@ set __TargetOS=windows
 set CMAKE_BUILD_TYPE=Debug
 set __Ninja=1
 set __icuDir=""
-set __usePThreads=0
 set __ExtraCmakeParams=
 set __CrossTarget=0
 
@@ -39,15 +38,11 @@ if /i [%1] == [wasm]        ( set __BuildArch=wasm&&shift&goto Arg_Loop)
 
 if /i [%1] == [outconfig] ( set __outConfig=%2&&shift&&shift&goto Arg_Loop)
 
-if /i [%1] == [browser] ( set __TargetOS=browser&&shift&goto Arg_Loop)
-if /i [%1] == [wasi] ( set __TargetOS=wasi&&shift&goto Arg_Loop)
-
 if /i [%1] == [rebuild] ( set __BuildTarget=rebuild&&shift&goto Arg_Loop)
 
 if /i [%1] == [msbuild] ( set __Ninja=0&&shift&goto Arg_Loop)
 
 if /i [%1] == [icudir] ( set __icuDir=%2&&shift&&shift&goto Arg_Loop)
-if /i [%1] == [usepthreads] ( set __usePThreads=1&&shift&goto Arg_Loop)
 
 if /i [%1] == [-fsanitize] ( set __ExtraCmakeParams=%__ExtraCmakeParams% "-DCLR_CMAKE_ENABLE_SANITIZERS=$2"&&shift&&shift&goto Arg_Loop)
 if /i [%1] == [-cmakeargs] ( set __ExtraCmakeParams=%__ExtraCmakeParams% %2&&shift&&shift&goto Arg_Loop)
@@ -77,16 +72,11 @@ if %__CrossTarget% EQU 0 (
     call powershell -NoProfile -ExecutionPolicy ByPass -File "%__repoRoot%\eng\native\version\copy_version_files.ps1"
 )
 
-:: cmake requires forward slashes in paths
-set __cmakeRepoRoot=%__repoRoot:\=/%
-set __ExtraCmakeParams=%__ExtraCmakeParams% "-DCMAKE_REPO_ROOT=%__cmakeRepoRoot%"
 set __ExtraCmakeParams=%__ExtraCmakeParams% "-DCMAKE_BUILD_TYPE=%CMAKE_BUILD_TYPE%"
 
 if NOT %__icuDir% == "" (
     set __ExtraCmakeParams=%__ExtraCmakeParams% "-DCMAKE_ICU_DIR=%__icuDir%"
 )
-set __ExtraCmakeParams=%__ExtraCmakeParams% "-DCMAKE_USE_PTHREADS=%__usePThreads%"
-
 
 if [%__outConfig%] == [] set __outConfig=%__TargetOS%-%__BuildArch%-%CMAKE_BUILD_TYPE%
 
diff --git a/src/native/libs/build-native.proj b/src/native/libs/build-native.proj
index 32965c2e584c58..4bb1f0164d9e83 100644
--- a/src/native/libs/build-native.proj
+++ b/src/native/libs/build-native.proj
@@ -13,13 +13,13 @@
 
     <_RuntimeVariant />
     <_RuntimeVariant Condition="'$(WasmEnableThreads)' == 'true'">-threads</_RuntimeVariant>
-    <_UsePThreads />
-    <_UsePThreads Condition="'$(WasmEnableThreads)' == 'true'"> usepthreads</_UsePThreads>
-
     <_IcuDir Condition="'$(PkgMicrosoft_NETCore_Runtime_ICU_Transport)' != ''">$(PkgMicrosoft_NETCore_Runtime_ICU_Transport)/runtimes/$(TargetOS)-$(TargetArchitecture)$(_RuntimeVariant)/native</_IcuDir>
     <_IcuDirArg Condition="'$(_IcuDir)' != ''"> icudir "$(_IcuDir)"</_IcuDirArg>
 
-    <_BuildNativeArgs>$(_BuildNativeArgs)$(_IcuDirArg)$(_UsePThreads)</_BuildNativeArgs>
+    <_CMakeArgs Condition="'$(CMakeArgs)' != ''"> -cmakeargs "$(CMakeArgs)"</_CMakeArgs>
+    <_CMakeArgs Condition="'$(WasmEnableThreads)' == 'true'">$(_CMakeArgs) -cmakeargs "-DCMAKE_USE_PTHREADS=1"</_CMakeArgs>
+
+    <_BuildNativeArgs>$(_BuildNativeArgs)$(_IcuDirArg)$(_CMakeArgs)</_BuildNativeArgs>
   </PropertyGroup>
 
   <ItemGroup>
@@ -50,17 +50,14 @@
       <_PortableBuildArg Condition="'$(PortableBuild)' != 'true'"> -portablebuild=false</_PortableBuildArg>
       <_CrossBuildArg Condition="'$(CrossBuild)' == 'true'"> -cross</_CrossBuildArg>
       <_KeepNativeSymbolsBuildArg Condition="'$(KeepNativeSymbols)' != 'false'"> -keepnativesymbols</_KeepNativeSymbolsBuildArg>
-      <_MonoWasmMTCMakeArgs Condition="'$(WasmEnableThreads)' == 'true'"> -DMONO_WASM_MT=1</_MonoWasmMTCMakeArgs>
-      <_CMakeArgs Condition="'$(CMakeArgs)' != '' or '$(_MonoWasmMTCMakeArgs)' != ''"> -cmakeargs "$(CMakeArgs)$(_MonoWasmMTCMakeArgs)"</_CMakeArgs>
 
       <!--
         BuildNativeCompiler is a pass-through argument, to pass an argument to build-native.sh. It is intended to be
         used to force a specific compiler toolset.
       -->
       <_BuildNativeCompilerArg Condition="'$(BuildNativeCompiler)' != ''"> $(BuildNativeCompiler)</_BuildNativeCompilerArg>
-      <_BuildNativeUnixArgs>$(_BuildNativeArgs)$(_ProcessorCountArg)$(_PortableBuildArg)$(_CrossBuildArg)$(_BuildNativeCompilerArg)$(_KeepNativeSymbolsBuildArg)$(_CMakeArgs) $(Compiler)</_BuildNativeUnixArgs>
+      <_BuildNativeUnixArgs>$(_BuildNativeArgs)$(_ProcessorCountArg)$(_PortableBuildArg)$(_CrossBuildArg)$(_BuildNativeCompilerArg)$(_KeepNativeSymbolsBuildArg) $(Compiler)</_BuildNativeUnixArgs>
       <_BuildNativeBuildCommand>&quot;$(MSBuildThisFileDirectory)build-native.sh&quot; $(_BuildNativeUnixArgs)</_BuildNativeBuildCommand>
-      <_BuildNativeBuildCommand Condition="'$(TargetsBrowser)' == 'true'">bash -c 'source &quot;$(RepoRoot)src/mono/browser/emsdk/emsdk_env.sh&quot; &amp;&amp; $(_BuildNativeBuildCommand)'</_BuildNativeBuildCommand>
     </PropertyGroup>
 
     <ItemGroup>
@@ -100,11 +97,7 @@
           Condition="$([MSBuild]::IsOsPlatform(Windows))">
     <PropertyGroup>
         <_BuildNativeArgs Condition="'$(Ninja)' == 'false'">$(_BuildNativeArgs) msbuild</_BuildNativeArgs>
-        <_MonoWasmMTCMakeArgs Condition="'$(WasmEnableThreads)' == 'true'">-DMONO_WASM_MT=1</_MonoWasmMTCMakeArgs>
-        <_MonoWasmMTCMakeArgs Condition="'$(CMakeArgs)' != ''"> $(_MonoWasmMTCMakeArgs)</_MonoWasmMTCMakeArgs>
-        <_BuildNativeArgs Condition="'$(CMakeArgs)' != '' or '$(_MonoWasmMTCMakeArgs)' != ''">$(_BuildNativeArgs) -cmakeargs "$(CMakeArgs)$(_MonoWasmMTCMakeArgs)"</_BuildNativeArgs>
         <_BuildNativeBuildCommand>&quot;$(MSBuildThisFileDirectory)build-native.cmd&quot; $(_BuildNativeArgs)</_BuildNativeBuildCommand>
-        <_BuildNativeBuildCommand Condition="'$(TargetsBrowser)' == 'true'">call &quot;$([MSBuild]::NormalizePath('$(RepoRoot)src/mono/browser/emsdk', 'emsdk_env.cmd'))&quot; &amp;&amp; $(_BuildNativeBuildCommand)</_BuildNativeBuildCommand>
     </PropertyGroup>
     <!-- Run script that uses CMake to generate and build the native files. -->
     <!-- Use IgnoreStandardErrorWarningFormat because Arcade sets WarnAsError and we want to avoid upgrading compiler warnings to errors in release branches -->
diff --git a/src/native/libs/build-native.sh b/src/native/libs/build-native.sh
index 5055b05839de15..51d24980e7e9cb 100755
--- a/src/native/libs/build-native.sh
+++ b/src/native/libs/build-native.sh
@@ -21,10 +21,6 @@ handle_arguments() {
             __ShiftArgs=1
             ;;
 
-        usepthreads|-usepthreads)
-            __usePThreads=1
-            ;;
-
         staticliblink|-staticliblink)
             __StaticLibLink=1
             ;;
@@ -48,36 +44,11 @@ __StaticLibLink=0
 __UnprocessedBuildArgs=
 __VerboseBuild=false
 __icuDir=""
-__usePThreads=0
 
 source "$__RepoRootDir"/eng/native/build-commons.sh
 
 # Set cross build
-if [[ "$__TargetOS" == browser ]]; then
-    if [[ -z "$EMSDK_PATH" ]]; then
-        if [[ -d "$__RepoRootDir"/src/mono/browser/emsdk/ ]]; then
-            export EMSDK_PATH="$__RepoRootDir"/src/mono/browser/emsdk/
-        else
-            echo "Error: You need to set the EMSDK_PATH environment variable pointing to the emscripten SDK root."
-            exit 1
-        fi
-    fi
-    source "$EMSDK_PATH"/emsdk_env.sh
-    export CLR_CC=$(which emcc)
-elif [[ "$__TargetOS" == wasi ]]; then
-    if [[ -z "$WASI_SDK_PATH" ]]; then
-        if [[ -d "$__RepoRootDir"/src/mono/wasi/wasi-sdk ]]; then
-            export WASI_SDK_PATH="$__RepoRootDir"/src/mono/wasi/wasi-sdk
-        else
-            echo "Error: You need to set the WASI_SDK_PATH environment variable pointing to the WASI SDK root."
-            exit 1
-        fi
-    fi
-    export WASI_SDK_PATH="${WASI_SDK_PATH%/}/"
-    export CLR_CC="$WASI_SDK_PATH"bin/clang
-    export TARGET_BUILD_ARCH=wasm
-    __CMakeArgs="-DCLR_CMAKE_TARGET_OS=wasi -DCLR_CMAKE_TARGET_ARCH=wasm -DWASI_SDK_PREFIX=$WASI_SDK_PATH -DCMAKE_TOOLCHAIN_FILE=${WASI_SDK_PATH}/share/cmake/wasi-sdk-p2.cmake $__CMakeArgs"
-elif [[ "$__TargetOS" == ios || "$__TargetOS" == iossimulator ]]; then
+if [[ "$__TargetOS" == browser || "$__TargetOS" == wasi || "$__TargetOS" == ios || "$__TargetOS" == iossimulator ]]; then
     # nothing to do here
     true
 elif [[ "$__TargetOS" == tvos || "$__TargetOS" == tvossimulator ]]; then
@@ -158,7 +129,6 @@ fi
 if [[ -n "$__icuDir" ]]; then
     __CMakeArgs="-DCMAKE_ICU_DIR=\"$__icuDir\" $__CMakeArgs"
 fi
-__CMakeArgs="-DCMAKE_USE_PTHREADS=$__usePThreads $__CMakeArgs"
 
 # Set the remaining variables based upon the determined build configuration
 __outConfig="${__outConfig:-"$__TargetOS-$__TargetArch-$__BuildType"}"
diff --git a/src/native/minipal/descriptorlimit.c b/src/native/minipal/descriptorlimit.c
index b1550fdc8f74e3..e0605552705d7a 100644
--- a/src/native/minipal/descriptorlimit.c
+++ b/src/native/minipal/descriptorlimit.c
@@ -13,7 +13,7 @@
 
 bool minipal_increase_descriptor_limit(void)
 {
-#if TARGET_WASM
+#ifdef __wasm__
     // WebAssembly cannot set limits
 #elif TARGET_LINUX_MUSL
     // Setting RLIMIT_NOFILE breaks debugging of coreclr on Alpine Linux for some reason
diff --git a/src/native/minipal/memorybarrierprocesswide.c b/src/native/minipal/memorybarrierprocesswide.c
index b2fcad9ef789c0..7582332f86c9e9 100644
--- a/src/native/minipal/memorybarrierprocesswide.c
+++ b/src/native/minipal/memorybarrierprocesswide.c
@@ -2,14 +2,17 @@
 // The .NET Foundation licenses this file to you under the MIT license.
 
 #ifndef HOST_WINDOWS
-#include <assert.h>
-#include <pthread.h>
+
 #include <stdbool.h>
 #include <stdint.h>
+#include <assert.h>
+#include <minipal/memorybarrierprocesswide.h>
+
+#ifndef HOST_WASM
+#include <pthread.h>
 #include <stdio.h>
 #include <sys/mman.h>
 #include <unistd.h>
-#include <minipal/memorybarrierprocesswide.h>
 
 #ifdef __APPLE__
 #include <stdlib.h>
@@ -72,7 +75,7 @@ static bool CanFlushUsingMembarrier(void)
 static bool s_flushUsingMemBarrier = false;
 #endif // HAVE_SYS_MEMBARRIER_H
 
-#if !defined(HOST_APPLE) && !defined(HOST_WASM)
+#ifndef HOST_APPLE
 // Helper memory page used by the fallback path
 static uint8_t* g_helperPage = NULL;
 
@@ -80,7 +83,8 @@ static uint8_t* g_helperPage = NULL;
 static pthread_mutex_t g_flushProcessWriteBuffersMutex;
 
 static size_t s_pageSize = 0;
-#endif // !TARGET_APPLE && !HOST_WASM
+#endif // !HOST_APPLE
+#endif // !HOST_WASM
 
 static bool s_initializedMemoryBarrierSuccessfullyInitialized = false;
 
diff --git a/src/native/minipal/thread.h b/src/native/minipal/thread.h
index 48405dfb3195ae..a407cf28c69c60 100644
--- a/src/native/minipal/thread.h
+++ b/src/native/minipal/thread.h
@@ -43,7 +43,7 @@ extern "C" {
  */
 static inline size_t minipal_get_current_thread_id(void)
 {
-#if defined(__wasm) && defined(MONO_WASM_MT)
+#if defined(__wasm) && !defined(_REENTRANT)
     return 0;
 #else
 #if defined(__GNUC__) && !defined(__clang__) && defined(__cplusplus)