diff --git a/src/libraries/Microsoft.Extensions.Caching.Abstractions/ref/Microsoft.Extensions.Caching.Abstractions.cs b/src/libraries/Microsoft.Extensions.Caching.Abstractions/ref/Microsoft.Extensions.Caching.Abstractions.cs
index 11479bb17ef608..2545c9d147aba9 100644
--- a/src/libraries/Microsoft.Extensions.Caching.Abstractions/ref/Microsoft.Extensions.Caching.Abstractions.cs
+++ b/src/libraries/Microsoft.Extensions.Caching.Abstractions/ref/Microsoft.Extensions.Caching.Abstractions.cs
@@ -193,7 +193,7 @@ public enum HybridCacheEntryFlags
         DisableUnderlyingData = 1 << 4,
         DisableCompression = 1 << 5,
     }
-    public abstract class HybridCache
+    public abstract partial class HybridCache
     {
         public abstract System.Threading.Tasks.ValueTask<T> GetOrCreateAsync<TState, T>(string key, TState state, System.Func<TState, System.Threading.CancellationToken, System.Threading.Tasks.ValueTask<T>> factory,
             HybridCacheEntryOptions? options = null, System.Collections.Generic.IEnumerable<string>? tags = null, System.Threading.CancellationToken cancellationToken = default);
diff --git a/src/libraries/Microsoft.Extensions.Caching.Abstractions/ref/Microsoft.Extensions.Caching.Abstractions.csproj b/src/libraries/Microsoft.Extensions.Caching.Abstractions/ref/Microsoft.Extensions.Caching.Abstractions.csproj
index 8619d10a530691..d3ee579507d087 100644
--- a/src/libraries/Microsoft.Extensions.Caching.Abstractions/ref/Microsoft.Extensions.Caching.Abstractions.csproj
+++ b/src/libraries/Microsoft.Extensions.Caching.Abstractions/ref/Microsoft.Extensions.Caching.Abstractions.csproj
@@ -1,4 +1,4 @@
-<Project Sdk="Microsoft.NET.Sdk">
+<Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
     <TargetFrameworks>$(NetCoreAppCurrent);$(NetCoreAppPrevious);$(NetCoreAppMinimum);netstandard2.0;$(NetFrameworkMinimum)</TargetFrameworks>
@@ -11,6 +11,9 @@
   <ItemGroup Condition="'$(TargetFrameworkIdentifier)' == '.NETCoreApp'">
     <Compile Include="Microsoft.Extensions.Caching.Abstractions.netcoreapp.cs" />
   </ItemGroup>
+  <ItemGroup Condition="$([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', 'net10.0'))">
+    <Compile Include="Microsoft.Extensions.Caching.Abstractions.net10.cs" />
+  </ItemGroup>
 
   <ItemGroup Condition="'$(TargetFrameworkIdentifier)' != '.NETCoreApp'">
     <Compile Include="$(CoreLibSharedDir)System\Runtime\CompilerServices\IsExternalInit.cs"
diff --git a/src/libraries/Microsoft.Extensions.Caching.Abstractions/ref/Microsoft.Extensions.Caching.Abstractions.net10.cs b/src/libraries/Microsoft.Extensions.Caching.Abstractions/ref/Microsoft.Extensions.Caching.Abstractions.net10.cs
new file mode 100644
index 00000000000000..57aa53f1e513f7
--- /dev/null
+++ b/src/libraries/Microsoft.Extensions.Caching.Abstractions/ref/Microsoft.Extensions.Caching.Abstractions.net10.cs
@@ -0,0 +1,38 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.
+// ------------------------------------------------------------------------------
+// Changes to this file must follow the https://aka.ms/api-review process.
+// ------------------------------------------------------------------------------
+
+namespace Microsoft.Extensions.Caching.Hybrid
+{
+    public abstract partial class HybridCache
+    {
+        public System.Threading.Tasks.ValueTask<T> GetOrCreateAsync<T>(
+            System.ReadOnlySpan<char> key,
+            System.Func<System.Threading.CancellationToken, System.Threading.Tasks.ValueTask<T>> factory,
+            Microsoft.Extensions.Caching.Hybrid.HybridCacheEntryOptions? options = null,
+            System.Collections.Generic.IEnumerable<string>? tags = null,
+            System.Threading.CancellationToken cancellationToken = default) => throw null;
+        public virtual System.Threading.Tasks.ValueTask<T> GetOrCreateAsync<TState, T>(
+            System.ReadOnlySpan<char> key,
+            TState state,
+            System.Func<TState, System.Threading.CancellationToken, System.Threading.Tasks.ValueTask<T>> factory,
+            Microsoft.Extensions.Caching.Hybrid.HybridCacheEntryOptions? options = null,
+            System.Collections.Generic.IEnumerable<string>? tags = null,
+            System.Threading.CancellationToken cancellationToken = default) => throw null;
+        public System.Threading.Tasks.ValueTask<T> GetOrCreateAsync<T>(
+            ref System.Runtime.CompilerServices.DefaultInterpolatedStringHandler key,
+            System.Func<System.Threading.CancellationToken, System.Threading.Tasks.ValueTask<T>> factory,
+            Microsoft.Extensions.Caching.Hybrid.HybridCacheEntryOptions? options = null,
+            System.Collections.Generic.IEnumerable<string>? tags = null,
+            System.Threading.CancellationToken cancellationToken = default) => throw null;
+        public System.Threading.Tasks.ValueTask<T> GetOrCreateAsync<TState, T>(
+            ref System.Runtime.CompilerServices.DefaultInterpolatedStringHandler key,
+            TState state,
+            System.Func<TState, System.Threading.CancellationToken, System.Threading.Tasks.ValueTask<T>> factory,
+            Microsoft.Extensions.Caching.Hybrid.HybridCacheEntryOptions? options = null,
+            System.Collections.Generic.IEnumerable<string>? tags = null,
+            System.Threading.CancellationToken cancellationToken = default) => throw null;
+    }
+}
diff --git a/src/libraries/Microsoft.Extensions.Caching.Abstractions/src/Hybrid/HybridCache.cs b/src/libraries/Microsoft.Extensions.Caching.Abstractions/src/Hybrid/HybridCache.cs
index d1867d1090c0e8..40a7f5eff1e058 100644
--- a/src/libraries/Microsoft.Extensions.Caching.Abstractions/src/Hybrid/HybridCache.cs
+++ b/src/libraries/Microsoft.Extensions.Caching.Abstractions/src/Hybrid/HybridCache.cs
@@ -5,6 +5,7 @@
 using System.Collections;
 using System.Collections.Generic;
 using System.Linq;
+using System.Runtime.CompilerServices;
 using System.Threading;
 using System.Threading.Tasks;
 using Microsoft.Extensions.Caching.Distributed;
@@ -45,6 +46,101 @@ public ValueTask<T> GetOrCreateAsync<T>(string key, Func<CancellationToken, Valu
         HybridCacheEntryOptions? options = null, IEnumerable<string>? tags = null, CancellationToken cancellationToken = default)
         => GetOrCreateAsync(key, factory, WrappedCallbackCache<T>.Instance, options, tags, cancellationToken);
 
+#if NET10_0_OR_GREATER
+    /// <summary>
+    /// Asynchronously gets the value associated with the key if it exists, or generates a new entry using the provided key and a value from the given factory if the key is not found.
+    /// </summary>
+    /// <typeparam name="T">The type of the data being considered.</typeparam>
+    /// <param name="key">The key of the entry to look for or create.</param>
+    /// <param name="factory">Provides the underlying data service if the data is not available in the cache.</param>
+    /// <param name="options">Additional options for this cache entry.</param>
+    /// <param name="tags">The tags to associate with this cache item.</param>
+    /// <param name="cancellationToken">The <see cref="CancellationToken"/> used to propagate notifications that the operation should be canceled.</param>
+    /// <returns>The data, either from cache or the underlying data service.</returns>
+    public ValueTask<T> GetOrCreateAsync<T>(
+        ReadOnlySpan<char> key,
+        Func<CancellationToken, ValueTask<T>> factory,
+        HybridCacheEntryOptions? options = null,
+        IEnumerable<string>? tags = null,
+        CancellationToken cancellationToken = default)
+        => GetOrCreateAsync(key, factory, WrappedCallbackCache<T>.Instance, options, tags, cancellationToken);
+
+    /// <summary>
+    /// Asynchronously gets the value associated with the key if it exists, or generates a new entry using the provided key and a value from the given factory if the key is not found.
+    /// </summary>
+    /// <typeparam name="TState">The type of additional state required by <paramref name="factory"/>.</typeparam>
+    /// <typeparam name="T">The type of the data being considered.</typeparam>
+    /// <param name="key">The key of the entry to look for or create.</param>
+    /// <param name="factory">Provides the underlying data service if the data is not available in the cache.</param>
+    /// <param name="state">The state required for <paramref name="factory"/>.</param>
+    /// <param name="options">Additional options for this cache entry.</param>
+    /// <param name="tags">The tags to associate with this cache item.</param>
+    /// <param name="cancellationToken">The <see cref="CancellationToken"/> used to propagate notifications that the operation should be canceled.</param>
+    /// <returns>The data, either from cache or the underlying data service.</returns>
+    /// <remarks>Implementors may use the key span to attempt a local-cache synchronous 'get' without requiring the key as a <see cref="string"/>.</remarks>
+    public virtual ValueTask<T> GetOrCreateAsync<TState, T>(
+        ReadOnlySpan<char> key,
+        TState state,
+        Func<TState, CancellationToken, ValueTask<T>> factory,
+        HybridCacheEntryOptions? options = null,
+        IEnumerable<string>? tags = null,
+        CancellationToken cancellationToken = default)
+        => GetOrCreateAsync(key.ToString(), state, factory, options, tags, cancellationToken);
+
+    /// <summary>
+    /// Asynchronously gets the value associated with the key if it exists, or generates a new entry using the provided key and a value from the given factory if the key is not found.
+    /// </summary>
+    /// <typeparam name="T">The type of the data being considered.</typeparam>
+    /// <param name="key">The key of the entry to look for or create.</param>
+    /// <param name="factory">Provides the underlying data service if the data is not available in the cache.</param>
+    /// <param name="options">Additional options for this cache entry.</param>
+    /// <param name="tags">The tags to associate with this cache item.</param>
+    /// <param name="cancellationToken">The <see cref="CancellationToken"/> used to propagate notifications that the operation should be canceled.</param>
+    /// <returns>The data, either from cache or the underlying data service.</returns>
+    public ValueTask<T> GetOrCreateAsync<T>(
+        ref DefaultInterpolatedStringHandler key,
+        Func<CancellationToken, ValueTask<T>> factory,
+        HybridCacheEntryOptions? options = null,
+        IEnumerable<string>? tags = null,
+        CancellationToken cancellationToken = default)
+    {
+        // It is *not* an error that this Clear occurs before the "await"; by definition, the implementation is *required* to copy
+        // the value locally before an await, precisely because the ref-struct cannot bridge an await. Thus: we are fine to clean
+        // the buffer even in the non-synchronous completion scenario.
+        ValueTask<T> result = GetOrCreateAsync(key.Text, factory, WrappedCallbackCache<T>.Instance, options, tags, cancellationToken);
+        key.Clear();
+        return result;
+    }
+
+    /// <summary>
+    /// Asynchronously gets the value associated with the key if it exists, or generates a new entry using the provided key and a value from the given factory if the key is not found.
+    /// </summary>
+    /// <typeparam name="TState">The type of additional state required by <paramref name="factory"/>.</typeparam>
+    /// <typeparam name="T">The type of the data being considered.</typeparam>
+    /// <param name="key">The key of the entry to look for or create.</param>
+    /// <param name="factory">Provides the underlying data service if the data is not available in the cache.</param>
+    /// <param name="state">The state required for <paramref name="factory"/>.</param>
+    /// <param name="options">Additional options for this cache entry.</param>
+    /// <param name="tags">The tags to associate with this cache item.</param>
+    /// <param name="cancellationToken">The <see cref="CancellationToken"/> used to propagate notifications that the operation should be canceled.</param>
+    /// <returns>The data, either from cache or the underlying data service.</returns>
+    public ValueTask<T> GetOrCreateAsync<TState, T>(
+        ref DefaultInterpolatedStringHandler key,
+        TState state,
+        Func<TState, CancellationToken, ValueTask<T>> factory,
+        HybridCacheEntryOptions? options = null,
+        IEnumerable<string>? tags = null,
+        CancellationToken cancellationToken = default)
+    {
+        // It is *not* an error that this Clear occurs before the "await"; by definition, the implementation is *required* to copy
+        // the value locally before an await, precisely because the ref-struct cannot bridge an await. Thus: we are fine to clean
+        // the buffer even in the non-synchronous completion scenario.
+        ValueTask<T> result = GetOrCreateAsync(key.Text, state, factory, options, tags, cancellationToken);
+        key.Clear();
+        return result;
+    }
+#endif
+
     private static class WrappedCallbackCache<T> // per-T memoized helper that allows GetOrCreateAsync<T> and GetOrCreateAsync<TState, T> to share an implementation
     {
         // for the simple usage scenario (no TState), pack the original callback as the "state", and use a wrapper function that just unrolls and invokes from the state