diff --git a/eng/Dependencies.props b/eng/Dependencies.props
index b78ad89a9e3a..4f64075c07cb 100644
--- a/eng/Dependencies.props
+++ b/eng/Dependencies.props
@@ -79,12 +79,6 @@ and are generated based on the last package release.
     <LatestPackageReference Include="System.Threading.Channels" />
     <LatestPackageReference Include="System.ValueTuple" />
 
-    <!-- Runtime packages referenced only for exclusions -->
-    <LatestPackageReference Include="Microsoft.Win32.SystemEvents" />
-    <LatestPackageReference Include="System.Drawing.Common" />
-    <LatestPackageReference Include="System.Security.Permissions" />
-    <LatestPackageReference Include="System.Windows.Extensions" />
-
     <!-- Runtime packages required for crossgen -->
     <LatestPackageReference Include="Microsoft.NETCore.App.Runtime.win-x64" />
     <LatestPackageReference Include="Microsoft.NETCore.App.Runtime.win-x86" />
diff --git a/eng/Version.Details.xml b/eng/Version.Details.xml
index f870b0eb391e..6cc9f639f806 100644
--- a/eng/Version.Details.xml
+++ b/eng/Version.Details.xml
@@ -177,10 +177,6 @@
       <Uri>https://github.com/dotnet/runtime</Uri>
       <Sha>b7e72a4ab2cb4832d88f7f23a2493287f7bcc43b</Sha>
     </Dependency>
-    <Dependency Name="Microsoft.Win32.SystemEvents" Version="6.0.0-rc.2.21454.1">
-      <Uri>https://github.com/dotnet/runtime</Uri>
-      <Sha>b7e72a4ab2cb4832d88f7f23a2493287f7bcc43b</Sha>
-    </Dependency>
     <Dependency Name="Microsoft.Internal.Runtime.AspNetCore.Transport" Version="6.0.0-rc.2.21454.1">
       <Uri>https://github.com/dotnet/runtime</Uri>
       <Sha>b7e72a4ab2cb4832d88f7f23a2493287f7bcc43b</Sha>
@@ -197,10 +193,6 @@
       <Uri>https://github.com/dotnet/runtime</Uri>
       <Sha>b7e72a4ab2cb4832d88f7f23a2493287f7bcc43b</Sha>
     </Dependency>
-    <Dependency Name="System.Drawing.Common" Version="6.0.0-rc.2.21454.1">
-      <Uri>https://github.com/dotnet/runtime</Uri>
-      <Sha>b7e72a4ab2cb4832d88f7f23a2493287f7bcc43b</Sha>
-    </Dependency>
     <Dependency Name="System.IO.Pipelines" Version="6.0.0-rc.2.21454.1">
       <Uri>https://github.com/dotnet/runtime</Uri>
       <Sha>b7e72a4ab2cb4832d88f7f23a2493287f7bcc43b</Sha>
@@ -233,10 +225,6 @@
       <Uri>https://github.com/dotnet/runtime</Uri>
       <Sha>b7e72a4ab2cb4832d88f7f23a2493287f7bcc43b</Sha>
     </Dependency>
-    <Dependency Name="System.Security.Permissions" Version="6.0.0-rc.2.21454.1">
-      <Uri>https://github.com/dotnet/runtime</Uri>
-      <Sha>b7e72a4ab2cb4832d88f7f23a2493287f7bcc43b</Sha>
-    </Dependency>
     <Dependency Name="System.ServiceProcess.ServiceController" Version="6.0.0-rc.2.21454.1">
       <Uri>https://github.com/dotnet/runtime</Uri>
       <Sha>b7e72a4ab2cb4832d88f7f23a2493287f7bcc43b</Sha>
@@ -253,10 +241,6 @@
       <Uri>https://github.com/dotnet/runtime</Uri>
       <Sha>b7e72a4ab2cb4832d88f7f23a2493287f7bcc43b</Sha>
     </Dependency>
-    <Dependency Name="System.Windows.Extensions" Version="6.0.0-rc.2.21454.1">
-      <Uri>https://github.com/dotnet/runtime</Uri>
-      <Sha>b7e72a4ab2cb4832d88f7f23a2493287f7bcc43b</Sha>
-    </Dependency>
     <Dependency Name="Microsoft.Extensions.DependencyModel" Version="6.0.0-rc.2.21454.1">
       <Uri>https://github.com/dotnet/runtime</Uri>
       <Sha>b7e72a4ab2cb4832d88f7f23a2493287f7bcc43b</Sha>
diff --git a/eng/Versions.props b/eng/Versions.props
index a4b114298bae..a6cec994112b 100644
--- a/eng/Versions.props
+++ b/eng/Versions.props
@@ -106,12 +106,10 @@
     <MicrosoftExtensionsOptionsDataAnnotationsVersion>6.0.0-rc.2.21454.1</MicrosoftExtensionsOptionsDataAnnotationsVersion>
     <MicrosoftExtensionsOptionsVersion>6.0.0-rc.2.21454.1</MicrosoftExtensionsOptionsVersion>
     <MicrosoftExtensionsPrimitivesVersion>6.0.0-rc.2.21454.1</MicrosoftExtensionsPrimitivesVersion>
-    <MicrosoftWin32SystemEventsVersion>6.0.0-rc.2.21454.1</MicrosoftWin32SystemEventsVersion>
     <MicrosoftInternalRuntimeAspNetCoreTransportVersion>6.0.0-rc.2.21454.1</MicrosoftInternalRuntimeAspNetCoreTransportVersion>
     <SystemDiagnosticsDiagnosticSourceVersion>6.0.0-rc.2.21454.1</SystemDiagnosticsDiagnosticSourceVersion>
     <SystemDiagnosticsEventLogVersion>6.0.0-rc.2.21454.1</SystemDiagnosticsEventLogVersion>
     <SystemDirectoryServicesProtocolsVersion>6.0.0-rc.2.21454.1</SystemDirectoryServicesProtocolsVersion>
-    <SystemDrawingCommonVersion>6.0.0-rc.2.21454.1</SystemDrawingCommonVersion>
     <SystemIOPipelinesVersion>6.0.0-rc.2.21454.1</SystemIOPipelinesVersion>
     <SystemNetHttpJsonVersion>6.0.0-rc.2.21454.1</SystemNetHttpJsonVersion>
     <SystemNetHttpWinHttpHandlerVersion>6.0.0-rc.2.21454.1</SystemNetHttpWinHttpHandlerVersion>
@@ -120,12 +118,10 @@
     <SystemRuntimeCompilerServicesUnsafeVersion>6.0.0-rc.2.21454.1</SystemRuntimeCompilerServicesUnsafeVersion>
     <SystemSecurityCryptographyPkcsVersion>6.0.0-rc.2.21454.1</SystemSecurityCryptographyPkcsVersion>
     <SystemSecurityCryptographyXmlVersion>6.0.0-rc.2.21454.1</SystemSecurityCryptographyXmlVersion>
-    <SystemSecurityPermissionsVersion>6.0.0-rc.2.21454.1</SystemSecurityPermissionsVersion>
     <SystemServiceProcessServiceControllerVersion>6.0.0-rc.2.21454.1</SystemServiceProcessServiceControllerVersion>
     <SystemTextEncodingsWebVersion>6.0.0-rc.2.21454.1</SystemTextEncodingsWebVersion>
     <SystemTextJsonVersion>6.0.0-rc.2.21454.1</SystemTextJsonVersion>
     <SystemThreadingChannelsVersion>6.0.0-rc.2.21454.1</SystemThreadingChannelsVersion>
-    <SystemWindowsExtensionsVersion>6.0.0-rc.2.21454.1</SystemWindowsExtensionsVersion>
     <!-- Only listed explicitly to workaround https://github.com/dotnet/cli/issues/10528 -->
     <MicrosoftNETCorePlatformsVersion>6.0.0-rc.2.21454.1</MicrosoftNETCorePlatformsVersion>
     <!-- Packages from dotnet/efcore -->
diff --git a/src/Framework/App.Ref/src/Microsoft.AspNetCore.App.Ref.csproj b/src/Framework/App.Ref/src/Microsoft.AspNetCore.App.Ref.csproj
index 48791e68f596..e7868125ebf3 100644
--- a/src/Framework/App.Ref/src/Microsoft.AspNetCore.App.Ref.csproj
+++ b/src/Framework/App.Ref/src/Microsoft.AspNetCore.App.Ref.csproj
@@ -68,14 +68,6 @@ This package is an internal implementation of the .NET Core SDK and is not meant
       SkipGetTargetFrameworkProperties="true"
       UndefineProperties="TargetFramework;TargetFrameworks;RuntimeIdentifier;PublishDir" />
 
-    <!-- Omit System.Security.Permissions closure. https://github.com/dotnet/runtime/issues/54341
-         It is brought in by System.Security.Cryptography.Xml for netstandard2.0 compatibility
-         but not required in net6.0 since the types required exist in System.Security.AccessControl. -->
-    <Reference Include="Microsoft.Win32.SystemEvents" ExcludeAssets="All" />
-    <Reference Include="System.Drawing.Common" ExcludeAssets="All" />
-    <Reference Include="System.Security.Permissions" ExcludeAssets="All" />
-    <Reference Include="System.Windows.Extensions" ExcludeAssets="All" />
-
     <!-- Enforce build order. Targeting pack needs to bundle information about the runtime. -->
     <ProjectReference Include="..\..\App.Runtime\src\Microsoft.AspNetCore.App.Runtime.csproj">
       <ReferenceOutputAssembly>false</ReferenceOutputAssembly>
diff --git a/src/Framework/App.Runtime/src/Microsoft.AspNetCore.App.Runtime.csproj b/src/Framework/App.Runtime/src/Microsoft.AspNetCore.App.Runtime.csproj
index 7db491507a73..76362c47aad5 100644
--- a/src/Framework/App.Runtime/src/Microsoft.AspNetCore.App.Runtime.csproj
+++ b/src/Framework/App.Runtime/src/Microsoft.AspNetCore.App.Runtime.csproj
@@ -120,14 +120,6 @@ This package is an internal implementation of the .NET Core SDK and is not meant
       <IncludeAssets>Runtime;Native</IncludeAssets>
     </Reference>
 
-    <!-- Omit System.Security.Permissions closure. https://github.com/dotnet/runtime/issues/54341
-         It is brought in by System.Security.Cryptography.Xml for netstandard2.0 compatibility
-         but not required in net6.0 since the types required exist in System.Security.AccessControl. -->
-    <Reference Include="Microsoft.Win32.SystemEvents" ExcludeAssets="All" />
-    <Reference Include="System.Drawing.Common" ExcludeAssets="All" />
-    <Reference Include="System.Security.Permissions" ExcludeAssets="All" />
-    <Reference Include="System.Windows.Extensions" ExcludeAssets="All" />
-
     <Reference Include="Microsoft.NETCore.App.Runtime.$(RuntimeIdentifier)"
         ExcludeAssets="All"
         PrivateAssets="All"