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test.jsonl
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test.jsonl
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{"input": {"genes": ["PCCA", "PGAM1"], "cpd": ["Tetrahydrosarcinapterin", "D-Xylulose 5-phosphate", "CO2", "L-erythro-3-Methylmalyl-CoA", "2-Phosphoglycolate", "5-Formyl-5,6,7,8-tetrahydromethanopterin", "L-Serine", "D-Glucono-1,5-lactone 6-phosphate", "Glycolate", "D-Glucono-1,5-lactone", "D-Fructose 6-phosphate", "D-Gluconic acid", "Glycerone", "D-Glycerate", "4-Hydroxybutyryl-CoA"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["PDHB", "FH", "PKLR", "PCCA", "ALDH6A1", "PGD", "MMUT", "GAPDH", "SDHC", "AGXT", "GLUD1", "GOT1", "SUCLA2", "GCK", "AMT", "DLST"], "cpd": ["L-Alanine", "Phosphoenolpyruvate", "D-Glyceraldehyde 3-phosphate", "L-threo-3-Methylaspartate", "Succinyl-CoA", "D-Glyceraldehyde", "Dimethylamine", "Glycolate", "Trimethylamine", "Coenzyme B", "Methylamine", "Formate", "(3S)-Citryl-CoA", "beta-D-Glucose 6-phosphate", "4-Hydroxybutyryl-CoA", "O-Phospho-L-serine", "(3S)-Citramalyl-CoA", "D-Xylulose 5-phosphate", "D-Ribose 5-phosphate", "Propenoyl-CoA", "D-Fructose 1,6-bisphosphate", "alpha-D-Glucose"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["NAGLU", "IDUA", "ARSB", "IDS", "GALNS", "HYAL3", "GNS", "HPSE2", "HEXA", "SGSH", "HYAL4"], "cpd": ["Chondroitin 4-sulfate", "Hyaluronic acid", "Dermatan sulfate", "DWA-2", "Keratan sulfate", "Heparan sulfate"]}, "target": "Glycosaminoglycan degradation"}
{"input": {"genes": ["ACADL", "HACD4", "PPT1", "CPT1B", "ACSF3", "SCP2", "CPT1C", "ECHS1", "HADH", "MECR", "SCD", "HSD17B8", "ACSBG1", "ACSL4", "ACADM", "HACD1", "OXSM", "ELOVL1", "ACSL1", "CPT2", "ELOVL4", "ELOVL2", "ACACA", "MCAT", "FADS1"], "cpd": ["(8Z,11Z)-Icosadienoyl-CoA", "gamma-Linolenoyl-CoA", "trans-Hexadec-2-enoyl-CoA", "Malonate", "Oleoyl-[acyl-carrier protein]", "3-Oxohexanoyl-CoA", "(13Z,16Z)-Docosadienoyl-CoA", "Acetyl-CoA", "Butanoyl-CoA", "Tetradecanoyl-[acp]", "(3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]", "3-Oxodecanoyl-CoA", "(10Z,13Z,16Z,19Z,22Z)-Octacosapentaenoyl-CoA", "Acetyl-CoA", "3-Oxotetradecanoyl-CoA"]}, "target": "Fatty acid metabolism"}
{"input": {"genes": ["AACS", "HMGCS2", "MMUT", "HSD17B10", "HMGCS1", "MCCC1", "EHHADH", "PCCA", "ALDH3A2", "ACSF3", "ACADS", "ECHS1", "HADHB", "IL4I1", "ALDH6A1", "DLD"], "cpd": ["3-Methyl-1-hydroxybutyl-ThPP", "(S)-Methylmalonyl-CoA", "Enzyme N6-(lipoyl)lysine", "L-Leucine", "Acetoacetate", "2-Methylpropanoyl-CoA", "2-Methylbut-2-enoyl-CoA", "[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine"]}, "target": "Valine, leucine and isoleucine degradation"}
{"input": {"genes": ["HADH", "ACAT2", "AACS", "ACSF3", "HIBADH", "ACADSB", "HMGCLL1", "AUH", "ALDH7A1", "MCCC1", "BCKDHA", "IL4I1", "HMGCS2", "HMGCS1", "PCCB", "OXCT2", "ALDH9A1", "ALDH3A2", "BCAT1", "ACADS", "ALDH2", "ACAT1", "OXCT1"], "cpd": ["Acetyl-CoA", "3-Methyl-2-oxobutanoic acid", "L-Isoleucine", "(S)-Methylmalonyl-CoA", "2-Methylacetoacetyl-CoA", "Acetoacetate", "Methylmalonate", "Thiamin diphosphate", "[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine", "L-Leucine", "(S)-3-Hydroxyisobutyrate", "Enzyme N6-(lipoyl)lysine", "Branched chain fatty acid", "2-Methylbut-2-enoyl-CoA", "2-Methylprop-2-enoyl-CoA", "[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine", "Enzyme N6-(lipoyl)lysine", "3-Methylcrotonyl-CoA", "3-Hydroxyisovalerate", "2-Methylpropanoyl-CoA", "3-Methylglutaconyl-CoA", "(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA", "(R)-3-Amino-2-methylpropanoate"]}, "target": "Valine, leucine and isoleucine degradation"}
{"input": {"genes": ["GOT1L1", "GOT1", "IL4I1", "GOT2"], "cpd": ["3-(4-Hydroxyphenyl)pyruvate", "Phenylpyruvate", "Phosphoenolpyruvate", "Shikimate", "D-Erythrose 4-phosphate", "1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "5-O-(1-Carboxyvinyl)-3-phosphoshikimate", "L-Tryptophan", "2-Benzylmalic acid", "D-Fructose 1-phosphate", "3-Dehydroquinate", "L-Homophenylalanine", "(4R,5R)-4,5-Dihydroxycyclohexa-1(6),2-diene-1-carboxylate", "Quinate", "Shikimate 3-phosphate", "2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate", "Indole", "L-Arogenate"]}, "target": "Phenylalanine, tyrosine and tryptophan biosynthesis"}
{"input": {"genes": ["ACAT2", "ACADL", "ACSL3", "ADH5", "CPT1B", "HADHB", "ACOX3", "ACADSB", "ADH7", "ACSL4"], "cpd": ["Acyl-carrier protein", "(S)-3-Hydroxyhexadecanoyl-CoA", "CoA", "Palmitoyl-CoA", "(R)-3-Hydroxybutanoyl-CoA", "Fatty acid", "3-Oxododecanoyl-CoA", "omega-Hydroxy fatty acid", "(S)-3-Hydroxyoctanoyl-CoA", "(S)-3-Hydroxytetradecanoyl-CoA", "(S)-3-Hydroxydodecanoyl-CoA", "L-Palmitoylcarnitine", "3-Oxopalmitoyl-CoA", "Aldehyde"]}, "target": "Fatty acid degradation"}
{"input": {"genes": ["ACOT8", "AMACR", "SLC27A5", "HSD3B7", "BAAT", "CYP46A1", "CYP27A1", "AKR1D1", "AKR1C4", "ACOX2", "SCP2", "CYP7A1", "HSD17B4", "CH25H"], "cpd": ["Glycine", "7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one", "3alpha,7alpha-Dihydroxy-5beta-cholestanate", "3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate", "(24R,25R)-3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA", "Cholic acid", "(24E)-3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA", "(25S)-3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA", "3alpha,7alpha-Dihydroxy-5beta-24-oxocholestanoyl-CoA", "7alpha,25-Dihydroxy-4-cholesten-3-one", "3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al", "Cerebrosterol", "(25R)-3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA", "Glycine", "(24S)-Cholest-5-ene-3beta,7alpha,24-triol", "4-Cholesten-7alpha,12alpha-diol-3-one", "Chenodeoxycholate", "Cholest-5-ene-3beta,26-diol", "7alpha,27-Dihydroxycholesterol", "Chenodeoxycholoyl-CoA"]}, "target": "Primary bile acid biosynthesis"}
{"input": {"genes": ["GALNT3", "GCNT1", "GALNT8", "GALNT11", "B3GNT3", "GALNT1", "GALNT5", "ST6GALNAC3", "ST6GALNAC4", "ST3GAL2", "POC1B-GALNT4", "GALNT9", "GALNT10", "GALNT16", "C1GALT1C1", "GALNT6"], "cpd": ["[Protein]-L-serine", "UDP-N-acetyl-D-galactosamine", "Tn antigen", "Sialyl-Tn antigen", "T antigen"]}, "target": "Mucin type O-glycan biosynthesis"}
{"input": {"genes": ["B4GALT3", "B4GAT1", "POMGNT2", "B4GALT1", "FUT4", "RXYLT1", "LARGE2"], "cpd": ["O-mannose core M3", "CDP-ribitol", "O-Mannose core M2", "O-Mannose core M1", "[Protein]-L-serine", "CTP"]}, "target": "Mannose type O-glycan biosynthesis"}
{"input": {"genes": ["AGXT", "AMT"], "cpd": ["Oxalate", "Oxaloacetate", "Propanoyl-CoA", "Acetate", "Ethylene glycol", "Glycine", "cis-Aconitate", "Mesaconate", "Succinyl-CoA", "D-Ribulose 1-phosphate", "Hydrogen peroxide", "Glycolate", "Succinate", "2-Hydroxy-3-oxopropanoate"]}, "target": "Glyoxylate and dicarboxylate metabolism"}
{"input": {"genes": ["MAT2A", "IDH2", "RPE", "ALDH18A1", "PFKL", "ABHD14A-ACY1", "GAPDH", "ARG2", "SDS", "ENO4", "PRPS1L1"], "cpd": ["2-Oxoadipate", "N-Acetylornithine", "LysW-L-ornithine", "L-Lysine", "D-Fructose 1,6-bisphosphate", "L-Aspartate 4-semialdehyde", "Phosphoribosyl-AMP", "N-Succinyl-2-L-amino-6-oxoheptanedioate", "3-Methyl-2-oxobutanoic acid", "LL-2,6-Diaminoheptanedioate", "L-Proline", "L-Citrulline"]}, "target": "Biosynthesis of amino acids"}
{"input": {"genes": ["CPT1C", "ELOVL5", "ACAT1", "MECR", "ACSL6", "CPT2", "ELOVL4", "SCD", "ACOX1", "ACSBG1", "HADHA", "ACADM", "ECHS1", "ACAA2"], "cpd": ["(4Z,7Z,10Z,13Z,16Z)-Docosapentaenoyl-CoA", "Decanoyl-CoA", "Docosenoyl-CoA", "trans-Dec-2-enoyl-CoA", "(2E)-Octadecenoyl-CoA"]}, "target": "Fatty acid metabolism"}
{"input": {"genes": ["SUCLG1", "PCCB", "DLD", "LDHAL6B", "SUCLA2", "SUCLG2", "MLYCD", "ACSS3", "ACACB", "LDHB", "LDHA", "BCKDHA", "HADHA", "ACACA", "PCCA", "MCEE", "ACSS2"], "cpd": ["Propenoyl-CoA", "2-Hydroxybutanoic acid", "beta-Alanine", "2-(alpha-Hydroxypropyl)thiamine diphosphate", "(S)-Lactaldehyde", "(S)-Methylmalonate semialdehyde", "(S)-Methylmalonyl-CoA", "3-Oxopropanoate"]}, "target": "Propanoate metabolism"}
{"input": {"genes": ["GPT", "NIT2", "GLS2", "ALDH5A1", "ADSS1", "IL4I1", "ASNS", "RIMKLA", "ASPA", "GLUD2", "ASS1", "FOLH1", "PPAT", "ALDH4A1", "ASRGL1", "ADSS2"], "cpd": ["L-Glutamine", "N-Acetylaspartylglutamate", "5-Phosphoribosylamine", "L-Asparagine", "N-(L-Arginino)succinate", "Succinate", "L-Glutamate", "N-Acetylaspartylglutamylglutamate", "Pyruvate", "2-Oxoglutarate", "L-Alanine", "D-Glucosamine 6-phosphate", "Fumarate", "Citrate", "Succinate semialdehyde", "N6-(1,2-Dicarboxyethyl)-AMP", "D-Aspartate", "N-Acetyl-L-aspartate", "N-Carbamoyl-L-aspartate", "Ammonia", "Carbamoyl phosphate", "beta-Citryl-L-glutamate", "4-Aminobutanoate"]}, "target": "Alanine, aspartate and glutamate metabolism"}
{"input": {"genes": ["ACAT2", "HMGCS2", "HMGCS1", "PMVK", "ZMPSTE24", "GGPS1", "CHURC1-FNTB", "ICMT", "NUS1", "PDSS1"], "cpd": ["(R)-Mevalonate", "Protein C-terminal S-farnesyl-L-cysteine methyl ester", "Acetyl-CoA", "2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol", "trans,trans-Farnesyl diphosphate", "(S)-3-Hydroxy-3-methylglutaryl-CoA", "2-trans,6-trans-Farnesal", "Polyprenol", "tritrans,heptacis-Undecaprenyl diphosphate", "Isopentenyl diphosphate", "trans,octacis-Decaprenyl diphosphate", "Geranyl diphosphate", "Acetoacetyl-CoA", "2-C-Methyl-D-erythritol 4-phosphate", "(R)-Mevalonate 3,5-bisphosphate", "all-trans-Heptaprenyl diphosphate", "all-trans-Octaprenyl diphosphate", "Protein C-terminal S-farnesyl-L-cysteine", "di-trans,poly-cis-Undecaprenyl diphosphate", "Geranylgeranyl diphosphate"]}, "target": "Terpenoid backbone biosynthesis"}
{"input": {"genes": ["OXCT2", "HADH", "HMGCS1", "ACSM4", "ACAT1", "HMGCS2", "OXCT1", "HMGCLL1", "AACS", "ACSM5", "ACSM2A", "EHHADH", "L2HGDH", "BDH1", "ACSM1", "HADHA"], "cpd": ["(S)-Acetoin", "Butanal", "4-Aminobutanoate", "Butanoic acid", "Pyruvate", "4-Hydroxybutyryl-CoA"]}, "target": "Butanoate metabolism"}
{"input": {"genes": ["PCBD1", "ALPP", "QDPR", "AKR1C3", "TPH2", "AKR1B1", "MOCOS", "AKR1B15", "GPHN", "DHFR", "ALPL", "TPH1", "FPGS", "PCBD2", "MOCS1", "GGH", "GCH1", "TH", "MOCS2", "ALPI", "PAH", "SPR"], "cpd": ["Precursor Z", "7,8-Dihydroneopterin 2',3'-cyclic phosphate", "Molybdopterin"]}, "target": "Folate biosynthesis"}
{"input": {"genes": ["SRR", "GLS", "DAO", "GLS2"], "cpd": ["Pyruvate", "5-Oxo-D-proline", "Cadaverine", "D-Cysteine", "D-Arginine", "D-Proline", "L-Phenylalanine", "5-Aminopentanoate", "L-Proline", "L-Serine"]}, "target": "D-Amino acid metabolism"}
{"input": {"genes": ["ST6GAL1", "ALG3", "DOLPP1", "DPM1", "STT3A", "ALG14", "B4GALT1", "ST6GAL2", "TUSC3", "RPN1", "DPM3", "MGAT2", "MGAT4D", "GANAB", "ALG2", "ALG1", "MAN1B1", "ALG12", "MAN1A1", "ALG6", "MGAT4C", "TMEM258", "ALG5", "MGAT3"], "cpd": ["Dolichol", "Dolichyl phosphate D-mannose", "Polyprenol", "N,N'-Chitobiosyldiphosphodolichol"]}, "target": "N-Glycan biosynthesis"}
{"input": {"genes": ["GNS", "NAGLU", "GALNS", "HYAL1", "HEXA", "IDUA", "IDS", "HEXB", "SGSH"], "cpd": ["Hyaluronic acid", "DWA-2"]}, "target": "Glycosaminoglycan degradation"}
{"input": {"genes": ["UPB1", "VNN2"], "cpd": ["(R)-Pantoate", "(R)-4-Phosphopantoate", "Dephospho-CoA", "L-Cysteine", "Apo-[acyl-carrier-protein]", "3-Methyl-2-oxobutanoic acid", "CoA", "N-((R)-Pantothenoyl)-L-cysteine", "(R)-3,3-Dimethylmalate", "(S)-2-Acetolactate", "Pantetheine", "Pyruvate", "Uracil", "Pantothenol", "(R)-4'-Phosphopantothenoyl-L-cysteine"]}, "target": "Pantothenate and CoA biosynthesis"}
{"input": {"genes": ["GAD1", "GLS2", "NIT2", "CPS1", "ASRGL1", "GFPT1", "ADSS1", "GPT", "GLUD1", "GLUL", "IL4I1", "GOT1", "RIMKLA", "GAD2", "GLS", "GOT1L1", "NAT8L", "ASS1", "ABAT", "ADSL", "GLUD2", "ADSS2", "PPAT", "ASNS"], "cpd": ["Succinate semialdehyde", "D-Aspartate", "beta-Citryl-L-glutamate", "5-Phosphoribosylamine", "2-Oxoglutarate"]}, "target": "Alanine, aspartate and glutamate metabolism"}
{"input": {"genes": ["PDHB", "DHTKD1", "LIPT2", "", "ACSM1", "DLD"], "cpd": ["2-Oxoglutarate", "Enzyme N6-(dihydrolipoyl)lysine", "Glycine", "3-Methyl-2-oxobutanoic acid", "Ammonia", "[Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine"]}, "target": "Lipoic acid metabolism"}
{"input": {"genes": ["BBOX1", "AASS", "PLOD3", "DOT1L", "KMT2C", "PIPOX", "SETMAR", "HADH", "COLGALT1", "SETD1B", "PRDM2", "EZH2", "KMT2B", "SMYD3", "PHYKPL", "EZH1", "PLOD1"], "cpd": ["Glutarate", "L-2-Aminoadipate", "(2R,5S)-2,5-Diaminohexanoate", "4-Carboxy-1-hydroxybutyryl-ThPP", "(S)-3-Hydroxybutanoyl-CoA", "Protein N6,N6,N6-trimethyl-L-lysine", "(3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine"]}, "target": "Lysine degradation"}
{"input": {"genes": ["PFKP", "PGD", "RPE", "H6PD", "G6PD", "ALDOB", "PGM2", "FBP1", "PGM1", "TKTL1", "GPI", "ALDOC", "PRPS1L1", "FBP2", "PGLS", "TKTL2", "SHPK", "RPEL1", "PRPS1", "PFKM", "TKT", "RBKS", "TALDO1"], "cpd": ["D-Glyceraldehyde 3-phosphate", "D-Ribulose 5-phosphate", "D-Xylulose 5-phosphate", "2-Keto-D-gluconic acid", "alpha-D-Ribose 1-phosphate", "D-Ribulose 1,5-bisphosphate", "2-Phospho-D-glycerate", "D-Glucono-1,5-lactone 6-phosphate", "5-Phospho-alpha-D-ribose 1-diphosphate", "D-Glucose"]}, "target": "Pentose phosphate pathway"}
{"input": {"genes": ["B4GALT1", "LARGE1", "FUT4", "B4GALT3", "RXYLT1", "FKTN", "MGAT5B", "B3GAT1", "B3GAT2", "POMGNT1", "LARGE2", "POMK", "POMGNT2", "POMT2", "ST3GAL3", "B4GAT1", "POMT1", "CRPPA", "FKRP"], "cpd": ["CTP", "[Protein]-L-serine", "Phospho-core M3", "O-Mannose core M1", "D-Ribitol 5-phosphate", "O-mannose core M3", "CDP-ribitol", "Dolichyl phosphate D-mannose", "O-Mannose core M2"]}, "target": "Mannose type O-glycan biosynthesis"}
{"input": {"genes": ["UGP2", "GFPT2", "HK1", "GPI", "GNE", "GFPT1", "NANP", "UXS1", "GMPPA", "HK3", "GALT", "GALE", "FCSK", "CMAS"], "cpd": ["CDP-3,6-dideoxy-D-mannose", "GDP-N-formyl-alpha-D-perosamine", "dTDP-4-oxo-2,6-dideoxy-D-allose", "N-Acetyl-D-galactosamine", "UDP-2-acetamido-2,6-dideoxy-beta-L-mannose", "L-Fucose", "dTDP-3-methyl-4-oxo-2,6-dideoxy-L-allose", "D-Glucosamine", "UDP-L-arabinose", "ADP-glucose", "5-N-Acetyl-7-N-(D-alanyl)-legionaminic acid", "N-Acetyl-alpha-D-glucosamine 1-phosphate", "CMP-5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic acid", "UDP-D-xylose", "dTDP-L-olivose", "alpha-D-Glucose"]}, "target": "Biosynthesis of nucleotide sugars"}
{"input": {"genes": ["PDXK", "AOX1"], "cpd": ["Pyridoxamine", "2-Oxo-3-hydroxy-4-phosphobutanoate", "3-Hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate", "Pyridoxamine phosphate", "2-(Acetamidomethylene)succinate", "4-Pyridoxate", "2-Amino-3-oxo-4-phosphonooxybutyrate", "3-Hydroxy-2-methylpyridine-5-carboxylate", "D-Ribose 5-phosphate", "3-Hydroxy-2-methylpyridine-4,5-dicarboxylate", "4-Hydroxy-L-threonine"]}, "target": "Vitamin B6 metabolism"}
{"input": {"genes": ["ECHS1", "THEM4", "HACD4", "THEM5", "PPT1", "HACD2", "TECR", "HADHA", "ELOVL7", "ACAA2", "ELOVL1", "ELOVL3", "HACD3", "ELOVL6", "ELOVL2", "ACOT2", "PPT2", "HSD17B12", "HADH", "ACOT1", "ELOVL4", "HACD1"], "cpd": ["Very-long-chain acyl-CoA", "trans-Hex-2-enoyl-CoA", "(S)-3-Hydroxyoctanoyl-CoA", "Hexanoyl-CoA"]}, "target": "Fatty acid elongation"}
{"input": {"genes": ["MTR", "TXNRD1"], "cpd": ["L-Selenocysteinyl-tRNA(Sec)", "Dimethyl selenide", "L-Selenocystathionine", "Methylselenocysteine Se-oxide", "Selenohomocysteine", "O-Phosphoseryl-tRNA(Sec)", "L-Alanine", "L-Seryl-tRNA(Sec)", "Selenomethionyl-tRNA(Met)", "1-Methylseleno-N-acetyl-D-galactosamine", "Glutathioselenol", "gamma-Glutamyl-Se-methylselenocysteine", "L-Selenomethionine", "Methylselenic acid", "Selenate", "Se-Methyl-L-selenocysteine", "Selenodiglutathione", "Selenite", "L-Seryl-tRNA(Sec)", "Trimethylselenonium", "Methylselenopyruvate"]}, "target": "Selenocompound metabolism"}
{"input": {"genes": ["ALDH3B2", "HDC"], "cpd": ["L-Glutamate", "4-(beta-Acetylaminoethyl)imidazole", "Ergothioneine", "Phosphoribosyl-AMP", "Imidazole-4-acetaldehyde", "Imidazole lactate", "beta-Alanyl-N(pi)-methyl-L-histidine", "N-Carbamyl-L-glutamate", "N-Formimino-L-glutamate", "5-Phospho-alpha-D-ribose 1-diphosphate", "4-Oxoglutaramate", "S-(Hercyn-2-yl)-L-cysteine S-oxide", "L-Histidinal", "Thiourocanic acid", "N(pi)-Methyl-L-histidine", "1-(5-Phosphoribosyl)imidazole-4-acetate", "5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide", "N-Formyl-L-glutamate", "1-(5-Phospho-D-ribosyl)-ATP", "3-(Imidazol-4-yl)-2-oxopropyl phosphate", "Methylimidazoleacetic acid", "4-Imidazolone-5-acetate", "gamma-L-Glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide"]}, "target": "Histidine metabolism"}
{"input": {"genes": ["ASL", "CAD", "CPS1", "GLS", "GOT2", "NOS2", "GLS2", "ABHD14A-ACY1", "NOS3", "ARG2"], "cpd": ["Fumarate", "Ammonia", "LysW-L-glutamate", "L-Ornithine", "L-Glutamine", "LysW-L-ornithine", "CO2", "LysW-L-glutamyl 5-phosphate", "N-Acetyl-L-glutamate 5-phosphate", "2-Oxoglutarate", "L-Glutamate"]}, "target": "Arginine biosynthesis"}
{"input": {"genes": ["GSTM1", "PGD", "GPX2", "GSS", "GSTT4", "GGT6", "IDH2"], "cpd": ["Homotrypanothione disulfide", "Trypanothione", "Dehydroascorbate", "L-Glutamate", "Putrescine", "R-S-Glutathione", "Glutathione", "L-Ornithine", "gamma-L-Glutamyl-L-cysteine", "Glutathionylspermidine", "Ascorbate", "Cys-Gly", "Spermine", "NADPH", "S-Substituted L-cysteine", "Cadaverine", "Tryparedoxin disulfide", "RX", "Glutathione disulfide", "NADPH"]}, "target": "Glutathione metabolism"}
{"input": {"genes": ["GAD1", "AOC2", "CNDP1", "ABAT", "UPB1", "CARNS1", "ALDH3B1", "GAD2", "CNDP2", "ALDH9A1", "ACOX1", "ALDH6A1", "SMOX", "AOC3"], "cpd": ["D-4'-Phosphopantothenate", "3-Aminopropanal", "4-Aminobutanoate", "beta-Alanyl-L-lysine", "Propanoyl-CoA", "Spermine", "Quinolinate", "Propenoyl-CoA", "L-Histidine", "beta-Alanine", "beta-Alanyl-L-arginine", "Pantothenate", "1,3-Diaminopropane", "L-Aspartate", "Malonyl-CoA", "3-Hydroxypropanoate", "Propynoate", "beta-Nitropropanoate", "Uracil", "4-Aminobutyraldehyde", "3-Aminopropiononitrile", "3-Ureidopropionate"]}, "target": "beta-Alanine metabolism"}
{"input": {"genes": ["FPGS", "MOCS2", "TH", "MOCS1", "GGH", "ALPG", "CBR1", "ALPL", "GCH1", "DHFR", "DHFR2", "PCBD1", "AKR1B1", "PTS", "ALPI", "PCBD2", "PAH", "TPH1", "ALPP", "TPH2", "SPR"], "cpd": ["Biopterin", "Tetrahydrofolate", "Neopterin", "Glycolaldehyde", "6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin", "4-Hydroxybenzoate", "(8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate", "N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate", "Adenylated molybdopterin", "THF-polyglutamate", "4-(beta-D-Ribofuranosyl)phenol 5'-phosphate"]}, "target": "Folate biosynthesis"}
{"input": {"genes": ["ACOT8", "CYP7A1", "AMACR", "CYP7B1", "BAAT", "CH25H"], "cpd": ["Taurine", "Cholest-5-ene-3beta,26-diol", "(24S)-Cholest-5-ene-3beta,7alpha,24-triol", "Chenodeoxycholate", "Glycochenodeoxycholate", "Cholic acid", "3beta,7alpha-Dihydroxy-5-cholestenoate", "Chenodeoxycholate"]}, "target": "Primary bile acid biosynthesis"}
{"input": {"genes": ["GANC", "GALM", "AKR1B1", "HK3", "AKR1B10", "AKR1B15", "UGP2", "GCK", "G6PC1", "PFKP", "PGM2", "G6PC3", "HKDC1", "B4GALT1", "GALE", "GLA"], "cpd": ["Lactose 6'-phosphate", "D-Tagatose", "alpha-D-Glucose", "Glycerol", "D-Sorbitol", "myo-Inositol", "D-Galactose", "D-Fructose 6-phosphate", "Sucrose", "D-Glyceraldehyde 3-phosphate", "2-Dehydro-3-deoxy-6-phospho-D-galactonate", "D-Tagatose 1,6-bisphosphate", "D-Mannose", "D-Fructose", "Raffinose", "Galactitol 1-phosphate", "D-Glyceraldehyde", "alpha-D-Galactose", "3-beta-D-Galactosyl-sn-glycerol"]}, "target": "Galactose metabolism"}
{"input": {"genes": ["SRD5A3", "DAD1", "DOLPP1", "ALG12", "MAN2A2", "DPM2", "MAN1B1", "MGAT3", "ST6GAL1", "RPN1", "B4GALT3", "ALG10", "MGAT4D", "DDOST", "MAN1A1", "MGAT5", "STT3B"], "cpd": ["Protein asparagine", "N,N'-Chitobiosyldiphosphodolichol", "N-Acetyl-D-glucosaminyldiphosphodolichol", "Dolichyl beta-D-glucosyl phosphate", "Dolichol", "Dolichyl phosphate D-mannose", "Polyprenol", "Dolichyl diphosphate", "GDP-mannose", "Dolichyl phosphate", "DS 3"]}, "target": "N-Glycan biosynthesis"}
{"input": {"genes": ["AOC2", "ALDH3B2", "AOC3", "ACOX1", "HIBCH"], "cpd": ["Malonate", "Acetyl-CoA", "L-Histidine", "3-Ureidopropionate", "L-Aspartate", "5,6-Dihydrouracil", "N-Acetyl-beta-alanine", "3-Hydroxypropionyl-CoA", "beta-Alanyl-L-arginine"]}, "target": "beta-Alanine metabolism"}
{"input": {"genes": ["BCAT1", "PHGDH", "APIP", "AMD1", "SMS", "MAT2A", "LDHAL6B", "SRM", "SDS", "CBS", "TST", "LACC1", "LDHAL6A"], "cpd": ["Aminoacyl-L-methionine", "L-Serine", "S-Methyl-5-thio-D-ribulose 1-phosphate", "(S)-2-Aminobutanoate"]}, "target": "Cysteine and methionine metabolism"}
{"input": {"genes": ["ST6GALNAC3", "HEXB", "ST3GAL5", "ST3GAL1", "ST6GALNAC5", "HEXA", "B4GALNT1"], "cpd": ["GT1aalpha", "GM2", "N-Acetylgalactosaminyl GD1a", "GD1a", "GQ1c", "N-Acetylgalactosaminyl GM1b", "GM1b", "GT1c", "GA2", "GT1b", "GQ1b", "Lactosylceramide", "GM1alpha", "GD3"]}, "target": "Glycosphingolipid biosynthesis - ganglio series"}
{"input": {"genes": ["ENO3", "PFKP", "ALDOB", "PDHA1", "BPGM", "ADH1A", "LDHC", "ALDOC", "PGK2", "ALDH9A1", "PDHB", "PGM1", "ACSS2", "GAPDHS", "ENO1", "HKDC1", "ALDH1B1", "PFKM", "PCK2", "PGM2", "TPI1"], "cpd": ["alpha-D-Glucose 6-phosphate", "alpha-D-Glucose", "Arbutin 6-phosphate", "Arbutin", "(S)-Lactate", "D-Glyceraldehyde 3-phosphate", "2-(alpha-Hydroxyethyl)thiamine diphosphate", "[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine", "Salicin", "Oxaloacetate", "Pyruvate", "Thiamin diphosphate", "D-Glucose 1-phosphate", "beta-D-Glucose 6-phosphate"]}, "target": "Glycolysis / Gluconeogenesis"}
{"input": {"genes": ["ACADS", "AACS", "HMGCLL1"], "cpd": ["(S)-2-Acetolactate", "Succinate semialdehyde", "Diacetyl", "meso-2,3-Butanediol", "2-Oxoglutarate", "Methanol", "Succinyl-CoA", "Poly-beta-hydroxybutyrate", "Glutaconyl-1-CoA", "(S,S)-Butane-2,3-diol", "Succinate"]}, "target": "Butanoate metabolism"}
{"input": {"genes": ["UGT1A5", "UGT2B11"], "cpd": ["Magnesium protoporphyrin monomethyl ester", "12,18-Didecarboxysiroheme", "Magnesium protoporphyrin"]}, "target": "Porphyrin metabolism"}
{"input": {"genes": ["TIGAR", "GMPPA", "PMM2", "PFKFB3", "ENOSF1", "MPI", "PFKL", "PFKP", "AKR1B15", "GFUS", "GMDS", "HK3", "FBP2", "SORD", "TKFC", "ALDOA", "PFKM", "PFKFB2", "PFKFB4", "FCSK", "ALDOB"], "cpd": ["L-Fuconate", "D-Glyceraldehyde", "D-Mannitol 1-phosphate", "L-Sorbose", "D-Allulose 6-phosphate", "GDP-L-fucose", "L-Rhamnonate"]}, "target": "Fructose and mannose metabolism"}
{"input": {"genes": ["PANK3", "BCAT2", "ENPP1", "AASDHPPT", "COASY", "ENPP3", "PANK2", "PANK1", "BCAT1", "PPCS", "CSAD", "ALDH1B1", "VNN2", "ALDH3A2", "ALDH2", "DPYS", "VNN1", "DPYD", "PPCDC", "GADL1"], "cpd": ["(R)-Pantoate", "Pantothenol", "3-Aminopropanal", "2-Dehydropantoate", "Apo-[acyl-carrier-protein]", "(R)-2,3-Dihydroxy-3-methylbutanoate", "CoA", "Adenosine 3',5'-bisphosphate", "N-((R)-Pantothenoyl)-L-cysteine", "Dephospho-CoA", "Pyruvate", "(R)-4'-Phosphopantothenoyl-L-cysteine", "Pantetheine", "beta-Alanine", "L-Cysteine", "Spermine", "(S)-2-Acetolactate", "Acyl-carrier protein", "3-Methyl-2-oxobutanoic acid", "Pantothenate", "5,6-Dihydrouracil", "Uracil", "(R)-4-Dehydropantoate", "(R)-3,3-Dimethylmalate"]}, "target": "Pantothenate and CoA biosynthesis"}
{"input": {"genes": ["FUT2", "B4GALT2"], "cpd": ["Type II A antigen", "IV4Gala-nLc4-Cer", "III3,IV2Fuca,IV3Gala-nLc4-Cer", "Type IIIA glycolipid", "V3Fuc-nLc6Cer", "IV2Fuc-Lc4Cer", "Type IIIAb", "Type IA glycolipid"]}, "target": "Glycosphingolipid biosynthesis - lacto and neolacto series"}
{"input": {"genes": ["GSTM3", "GSTT4", "GSTA2", "GCLC", "GCLM", "GGT6", "G6PD", "ODC1", "IDH1", "GSTM1", "IDH2", "GPX8", "GSTT1", "LAP3", "SMS", "GSTA5", "RRM1"], "cpd": ["(5-L-Glutamyl)-L-amino acid", "L-Glutamate"]}, "target": "Glutathione metabolism"}
{"input": {"genes": ["PIGY", "GPLD1", "PIGZ", "PIGX", "PIGH", "PIGU", "PIGS", "PIGF", "PGAP1", "PIGG", "PIGA", "PIGO", "GPAA1", "DPM2", "PIGT", "PIGQ", "PIGN", "PIGP", "PIGC", "PIGB"], "cpd": ["6-(alpha-D-glucosaminyl)-1D-myo-inositol", "Phosphatidylethanolamine", "Phosphatidylethanolamine", "1-Phosphatidyl-D-myo-inositol", "Ethanolamine phosphate", "UDP-N-acetyl-D-glucosamine"]}, "target": "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis"}
{"input": {"genes": ["CA3", "GLUD1", "CA14", "CPS1", "CA7", "CA9"], "cpd": ["Ammonia", "Ammonia", "Nitrite", "L-Glutamine", "Nitrate", "Nitrite", "Nitric oxide", "Carbamate", "Nitrite", "Nitrate", "Nitroalkane"]}, "target": "Nitrogen metabolism"}
{"input": {"genes": ["CARNS1", "ALDH1B1"], "cpd": ["N-Carbamyl-L-glutamate", "N-Formimino-L-aspartate", "4-Imidazolone-5-acetate", "Isoglutamine", "Dihydrourocanate", "L-Histidinol phosphate", "S-(Hercyn-2-yl)-L-cysteine S-oxide", "1-(5-Phospho-D-ribosyl)-ATP", "Imidazole-4-acetate", "4-(beta-Acetylaminoethyl)imidazole", "2-Oxoglutarate", "N-Formyl-L-aspartate", "Formylisoglutamine", "4-Imidazolone-5-propanoate", "5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide", "Hercynine", "N-Formimino-L-glutamate", "(1-Ribosylimidazole)-4-acetate", "Imidazol-5-yl-pyruvate", "Hydantoin-5-propionate", "4-Oxoglutaramate", "L-Histidinol", "Carnosine", "L-Aspartate", "N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide"]}, "target": "Histidine metabolism"}
{"input": {"genes": ["IDH3B", "SDHA", "MDH2", "OGDHL", "SUCLA2", "DLST", "PDHA2", "SUCLG1", "PDHA1", "IDH1", "IDH2", "ACO2", "SDHB", "SUCLG2", "PDHB", "MDH1", "DLD", "OGDH", "ACO1", "DLAT", "SDHC", "SDHD"], "cpd": ["Enzyme N6-(lipoyl)lysine", "[Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine", "2-(alpha-Hydroxyethyl)thiamine diphosphate", "Enzyme N6-(lipoyl)lysine"]}, "target": "Citrate cycle (TCA cycle)"}
{"input": {"genes": ["NAGA", "ABO", "HEXB", "FUT2", "GLA", "ST3GAL2", "GBGT1", "ST8SIA1"], "cpd": ["Forssman antigen, IV3GalNAca-Gb4Cer", "Globoside", "Globotriaosylceramide", "GalGb3Cer", "NOR2 antigen", "V3(NeuAc)2-Gb5Cer", "IV4-alpha-Gal-Gb4Cer", "Monosialylgalactosylgloboside"]}, "target": "Glycosphingolipid biosynthesis - globo and isoglobo series"}
{"input": {"genes": ["TECR", "ELOVL6", "ACOX1", "SCP2", "HACD2", "ACOX3"], "cpd": ["(4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid", "Eicosanoyl-CoA", "Docosanoyl-CoA", "Octadecanoyl-[acyl-carrier protein]", "Docosenoyl-CoA", "Ximenoyl-CoA", "(8Z,11Z)-Icosadienoyl-CoA", "(9Z,12Z,15Z)-Octadecatrienoic acid", "Palmitoyl-CoA"]}, "target": "Biosynthesis of unsaturated fatty acids"}
{"input": {"genes": ["PCCB", "SUCLG1", "ACSS3", "MMUT", "LDHA", "DLD", "HIBCH", "LDHC", "ACACB"], "cpd": ["Succinyl-CoA", "Acrylic acid", "3-Oxopropanoate", "Propanoate", "Propionyladenylate", "Enzyme N6-(lipoyl)lysine", "beta-Alanyl-CoA", "2-Methylcitrate", "Acetyl-CoA", "Propane-1-ol", "Hydroxyacetone", "(S)-Lactate", "Thiamin diphosphate", "3-Oxopropionyl-CoA", "2-Hydroxybutanoic acid", "(S)-Lactaldehyde", "(S)-Methylmalonyl-CoA", "(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate", "beta-Alanine", "Propane-1,2-diol", "Propynoate"]}, "target": "Propanoate metabolism"}
{"input": {"genes": ["DGKA", "PLA2G3", "AGPAT3", "PLD3", "PLA2G4C", "PLA2G10", "PLA2G15", "GPD1", "PLPP3", "MBOAT1", "PLA2G2C", "PLPP4", "AGPAT4", "GPD1L", "DGKQ", "PLPP2", "DGKD", "PLD4", "AGPAT5", "PLB1", "PLPP5"], "cpd": ["2-Acyl-sn-glycero-3-phosphocholine", "Acyl-CoA", "N-Methylethanolamine phosphate"]}, "target": "Glycerophospholipid metabolism"}
{"input": {"genes": ["UGT1A3", "UGT2B10", "GUSB", "KL", "UGT2B4", "UGT2B15", "UGT1A4", "UGT1A7", "UGT2B11"], "cpd": ["(4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate", "Ascorbate", "L-Arabinose", "Monodehydroascorbate", "L-Ribulose 5-phosphate", "2-Dehydro-3-deoxy-D-glucarate", "D-Tagaturonate", "L-Galactonate", "2,5-Dioxopentanoate", "L-Galactose", "Threonate", "2-Dehydro-3-deoxy-L-arabinonate", "D-Glucuronolactone", "D-Arabinonate", "L-Xylonate", "Dehydro-D-arabinono-1,4-lactone", "L-Ascorbate 6-phosphate", "D-Glucarate", "Dehydroascorbate", "GDP-mannose", "beta-L-Galactose 1-phosphate", "L-Gulose 1-phosphate", "D-Arabinose", "Pyruvate"]}, "target": "Ascorbate and aldarate metabolism"}
{"input": {"genes": ["ACAT2", "GGPS1", "HMGCR", "PCYOX1", "FNTB", "PMVK", "FNTA", "HMGCS1", "RCE1", "IDI2", "MVD", "IDI1", "PDSS1", "CHURC1-FNTB", "ICMT", "DHDDS", "PDSS2", "ACAT1", "MVK", "NUS1"], "cpd": ["2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol", "D-Glyceraldehyde 3-phosphate", "all-trans-Hexaprenyl diphosphate", "(S)-3-Hydroxy-3-methylglutaryl-CoA", "trans,polycis-Polyprenyl diphosphate", "Isopentenyl phosphate", "all-trans-Octaprenyl diphosphate", "2-C-Methyl-D-erythritol 4-phosphate", "all-trans-Heptaprenyl diphosphate", "(R)-5-Diphosphomevalonate", "Acetoacetyl-CoA", "Protein C-terminal S-farnesyl-L-cysteine methyl ester", "trans,octacis-Decaprenyl diphosphate", "Acetyl-CoA", "Farnesylcysteine", "Polyprenol", "2-trans,6-trans-Farnesal", "di-trans,poly-cis-Undecaprenyl diphosphate", "(R)-Mevalonate 3,5-bisphosphate", "(R)-Mevalonate", "1-Hydroxy-2-methyl-2-butenyl 4-diphosphate", "Protein C-terminal S-farnesyl-L-cysteine", "tritrans,heptacis-Undecaprenyl diphosphate", "trans-Anhydromevalonate phosphate"]}, "target": "Terpenoid backbone biosynthesis"}
{"input": {"genes": ["B3GNT4", "FUT3"], "cpd": ["Paragloboside", "Type IIIAb", "IV4GalNAcb-SPG ganglioside"]}, "target": "Glycosphingolipid biosynthesis - lacto and neolacto series"}
{"input": {"genes": ["HACD1", "HADHA", "ACOT4", "TECR", "ACOT2", "HADHB", "HACD2", "ACOT7", "MECR", "ELOVL2", "HSD17B12", "ELOVL1", "HADH", "ACAA2", "THEM5", "HACD4", "ACOT1", "THEM4"], "cpd": ["Very-long-chain 3-oxoacyl-CoA", "trans-Dec-2-enoyl-CoA", "Very-long-chain trans-2,3-dehydroacyl-CoA", "(S)-Hydroxydecanoyl-CoA"]}, "target": "Fatty acid elongation"}
{"input": {"genes": ["NT5M", "HDDC2", "PNP", "ENTPD1", "UPP1", "AK7", "LACC1", "NT5E", "APRT", "ADA", "AK1", "ENTPD3", "DTYMK", "IMPDH2", "XDH", "CMPK2", "RRM2B", "NUDT16", "CDA", "AK8", "AK2", "DCK"], "cpd": ["Deoxyadenosine", "Deoxyinosine", "dGTP", "dGDP", "Thymine", "XDP", "Cytosine", "GTP", "GMP", "Guanosine", "Deoxyguanosine", "dATP", "Deoxycytidine", "ADP", "L-Glutamine", "ATP", "CMP", "Deoxyuridine", "N6-(1,2-Dicarboxyethyl)-AMP", "dUMP", "UTP", "Adenine"]}, "target": "Nucleotide metabolism"}
{"input": {"genes": ["HSD17B12", "HACD2", "ACAA1", "ELOVL3"], "cpd": ["(11Z,14Z,17Z)-Icosatrienoyl-CoA", "(9Z)-Octadecenoic acid", "(4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoyl-CoA", "Sapienoyl-CoA", "(13Z,16Z)-Docosadienoic acid", "Ximenoyl-CoA", "Eicosanoyl-CoA", "Adrenic acid", "Icosenoyl-CoA", "Docosanoyl-CoA", "Oleoyl-[acyl-carrier protein]", "Tetracosanoyl-CoA", "Oleoyl-[acyl-carrier protein]", "gamma-Linolenoyl-CoA", "Linoleoyl-CoA", "Tetracosenoyl-CoA", "(9Z,12Z,15Z)-Octadecatrienoyl-CoA", "Stearoyl-CoA", "Docosanoyl-CoA", "Icosatrienoic acid"]}, "target": "Biosynthesis of unsaturated fatty acids"}
{"input": {"genes": ["EXTL1", "NDST2", "NDST4", "B3GALT6", "HS6ST2", "EXTL2", "HS6ST1", "GLCE", "EXT2", "HS3ST3B1", "B4GALT7", "HS3ST3A1", "NDST3", "EXTL3"], "cpd": ["Acetate", "Adenosine 3',5'-bisphosphate", "[Protein]-L-serine", "3'-Phosphoadenylyl sulfate"]}, "target": "Glycosaminoglycan biosynthesis - heparan sulfate / heparin"}
{"input": {"genes": ["GNPNAT1", "GCK", "UGDH", "PGM3", "GNE", "GALK2", "HKDC1", "GMDS", "UGP2", "UAP1L1", "UAP1", "HK1", "MPI", "NAGK", "HK2", "CMAS", "PGM2", "GFPT2", "PMM1", "MIOX", "NANP"], "cpd": ["dTDP-3-oxo-2,6-dideoxy-D-glucose", "alpha-D-Galactosamine 1-phosphate", "UDP-N-acetylmuramate", "dTDP-4-oxo-2,6-dideoxy-D-allose", "dTDP-3-methyl-4-oxo-2,6-dideoxy-L-allose", "dTDP-6-deoxy-D-allose", "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose", "D-Ribulose 5-phosphate", "D-glycero-alpha-D-manno-Heptose 1-phosphate", "N-Acetyl-alpha-D-galactosamine 1-phosphate", "UDP-3-ketoglucose", "dTDP-glucose", "dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose", "dTDP-4-amino-4,6-dideoxy-D-glucose", "GDP-6-deoxy-D-talose", "alpha-D-Arabinopyranose 1-phosphate", "GDP-L-fucose", "D-glycero-beta-D-manno-Heptose 1,7-bisphosphate", "N-Acetylmuramate", "GDP-4-dehydro-6-deoxy-D-mannose", "GDP-6-deoxy-D-manno-heptose"]}, "target": "Biosynthesis of nucleotide sugars"}
{"input": {"genes": ["ADH7", "PC", "ACAT2", "ADH5", "LDHB", "PDHA2", "ACSS1", "ACACB"], "cpd": ["Pyruvate", "Phosphoenolpyruvate", "Malonyl-CoA", "Acetate", "Acetoacetyl-CoA", "2-Hydroxyethylenedicarboxylate", "Ethanol", "Fumarate", "Oxaloacetate", "Enzyme N6-(dihydrolipoyl)lysine", "Acetyl adenylate", "Formate", "(R)-2-Hydroxybutane-1,2,4-tricarboxylate", "Succinate", "alpha-Isopropylmalate", "(R)-S-Lactoylglutathione", "Acetylenedicarboxylate", "(R)-2-Ethylmalate", "2-(alpha-Hydroxyethyl)thiamine diphosphate", "Acetyl-CoA", "(S)-Lactaldehyde"]}, "target": "Pyruvate metabolism"}
{"input": {"genes": ["AADAT", "CAT", "IDO1", "AOC1", "AANAT", "MAOB", "ECHS1", "INMT", "CYP1A1", "ALDH7A1", "HADHA", "CYP1A2", "DHTKD1", "MAOA", "ALDH2", "HADH", "ACMSD", "ACAT2", "KYAT1", "CYP1B1", "DLST", "GCDH", "ALDH9A1", "AOX1", "DDC"], "cpd": ["5-(2'-Formylethyl)-4,6-dihydroxypicolinate", "L-Formylkynurenine", "N-Acetylindoxyl", "5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate", "Indole", "5-Hydroxyindoleacetylglycine", "N-Acetylisatin", "Indolylmethyl-desulfoglucosinolate", "N-Methylserotonin", "(Indol-3-yl)glycolaldehyde", "Xanthurenic acid", "Anthranilate", "4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate", "Serotonin", "N-Acetylserotonin"]}, "target": "Tryptophan metabolism"}
{"input": {"genes": ["PIGC", "PIGZ", "PIGG", "PIGY", "PIGL", "PIGQ", "PIGV", "PIGS", "PIGX", "PIGM", "PIGH", "PIGA", "PIGF", "PIGB", "PIGU", "PIGO", "DPM2", "GPAA1", "PGAP1", "MPPE1"], "cpd": ["Palmitoyl-CoA", "Phosphatidylethanolamine", "Ethanolamine phosphate", "1-Phosphatidyl-D-myo-inositol", "6-(alpha-D-glucosaminyl)-1D-myo-inositol"]}, "target": "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis"}
{"input": {"genes": ["ALDH3A2", "CYP2U1", "ALDH1B1", "ACAA2", "ALDH2", "ADH1B"], "cpd": ["alpha-Hydroxy fatty acid", "Reduced rubredoxin", "3-Oxohexanoyl-CoA", "trans-Tetradec-2-enoyl-CoA", "Oxidized rubredoxin", "2-trans-Dodecenoyl-CoA", "3-Oxopalmitoyl-CoA", "(S)-Hydroxyhexanoyl-CoA", "(S)-3-Hydroxydodecanoyl-CoA", "Tetradecanoyl-CoA", "CoA", "trans-Hexadec-2-enoyl-CoA", "Fatty acid", "CoA", "(S)-3-Hydroxyhexadecanoyl-CoA", "Hexanoyl-CoA"]}, "target": "Fatty acid degradation"}
{"input": {"genes": ["BCAT1", "BCAT2", "SDSL", "SDS"], "cpd": ["L-Isoleucine", "2-Methylmaleate", "(R)-2,3-Dihydroxy-3-methylbutanoate", "L-Leucine", "(R)-2,3-Dihydroxy-3-methylpentanoate", "Acetyl-CoA", "3-Methyl-2-oxobutanoic acid", "L-Valine", "4-Methyl-2-oxopentanoate", "(R)-2-Methylmalate", "D-erythro-3-Methylmalate", "3-Hydroxy-3-methyl-2-oxobutanoic acid", "(S)-2-Aceto-2-hydroxybutanoate", "(S)-3-Methyl-2-oxopentanoic acid", "2-Oxobutanoate", "2-Isopropylmaleate", "(S)-2-Acetolactate", "alpha-Isopropylmalate", "Pyruvate"]}, "target": "Valine, leucine and isoleucine biosynthesis"}
{"input": {"genes": ["ENPP3", "ENPP1", "RFK", "ACP5", "ACP1", "ACP2", "BLVRB", "FLAD1"], "cpd": ["5-Amino-6-(1-D-ribitylamino)uracil", "L-3,4-Dihydroxybutan-2-one 4-phosphate", "Prenol", "Dimethylallyl phosphate", "Riboflavin", "Prenylated FMNH2", "7-Hydroxy-6-methyl-8-ribityllumazine", "Reduced riboflavin"]}, "target": "Riboflavin metabolism"}
{"input": {"genes": ["RRM2", "NT5C3B", "NT5C1A", "UPP2", "NT5DC4"], "cpd": ["Methylmalonate", "3-Oxo-3-ureidopropanoate", "2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate", "Pseudouridine 5'-phosphate", "UDP", "Deoxycytidine", "CMP", "2',3'-Cyclic UMP", "dCMP", "(Z)-3-Ureidoacrylate peracid", "L-Glutamine", "Carbamoyl phosphate", "3',5'-Cyclic UMP", "(R)-5,6-Dihydrothymine", "Uracil", "2'-Deoxy-5-hydroxymethylcytidine-5'-diphosphate", "Urea", "Thymine", "UDP", "3-Oxopropanoate"]}, "target": "Pyrimidine metabolism"}
{"input": {"genes": ["AMPD2", "XDH", "GMPS", "ENTPD6", "APRT", "ADSS1", "DUT", "NME1", "AK2", "NME1-NME2", "ASMTL", "NT5C1A", "ENTPD8", "DCK", "NT5E", "RRM2B", "TK1"], "cpd": ["Thymidine", "dADP", "GDP", "dGMP", "dCMP", "GMP", "Cytosine", "dAMP", "dTDP", "Xanthine", "Guanosine", "Uracil", "dCTP", "dGTP"]}, "target": "Nucleotide metabolism"}
{"input": {"genes": ["CEPT1", "CHPT1", "PCYT2"], "cpd": ["Phosphonoacetate", "Diacylglyceryl-2-aminoethylphosphonate", "Phosphoenolpyruvate", "Acetaldehyde", "Bialaphos", "3-Phosphonopyruvate", "alpha-D-Ribose 1-methylphosphonate 5-triphosphate"]}, "target": "Phosphonate and phosphinate metabolism"}
{"input": {"genes": ["PLA2G4B", "PLA2G4D", "PLA2G2D", "CYP2J2", "PLA2G12A", "PLA2G3", "PLA2G4E", "PLAAT3", "PLA2G6", "JMJD7-PLA2G4B", "PLB1", "PLA2G4A", "PLA2G1B"], "cpd": ["5S,8R-DiHODE", "(8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate", "9(10)-EpOME", "9,10-Dihydroxy-12,13-epoxyoctadecanoate", "Rumenic acid", "Linoleate", "Phosphatidylcholine", "9,12,13-TriHOME", "(6Z,9Z,12Z)-Octadecatrienoic acid", "9,10,13-TriHOME", "Arachidonate", "Crepenynate", "(9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid", "9(S)-HPODE", "9,10-12,13-Diepoxyoctadecanoate", "(9Z,11E)-12-[(1E)-Hex-1-en-1-yloxy]dodeca-9,11-dienoic acid", "(9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid"]}, "target": "Linoleic acid metabolism"}
{"input": {"genes": ["PC", "IDH3A", "OGDH", "PDHA2", "MDH1", "PDHA1", "ACO2", "SDHA", "DLD", "PDHB", "MDH2", "DLAT"], "cpd": ["Enzyme N6-(lipoyl)lysine", "Succinyl-CoA", "Succinate", "2-(alpha-Hydroxyethyl)thiamine diphosphate", "Enzyme N6-(dihydrolipoyl)lysine", "Oxaloacetate", "Isocitrate", "[Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine", "(S)-Malate", "3-Carboxy-1-hydroxypropyl-ThPP", "Fumarate", "Acetyl-CoA", "Pyruvate", "Citrate"]}, "target": "Citrate cycle (TCA cycle)"}
{"input": {"genes": ["AKR1B1", "HK2", "PFKM", "PMM2", "ALDOC", "HK1", "GMDS", "MPI", "AKR1B10", "FPGT", "FBP1", "HK3"], "cpd": ["GDP-L-fucose", "D-Sorbitol", "L-Fucose", "(beta-D-Mannuronate)n", "D-Mannose", "(S)-Lactaldehyde", "D-Allose", "D-Mannitol 1-phosphate", "D-Fructose 6-phosphate", "ADP-mannose", "D-Allose 6-phosphate", "D-Mannose 6-phosphate", "D-Sorbitol", "L-Fuculose 1-phosphate", "L-Rhamnono-1,4-lactone", "L-Sorbose", "L-Rhamnulose", "Fructan", "D-Mannose 1-phosphate", "GDP-4-dehydro-6-deoxy-D-mannose", "Mannitol"]}, "target": "Fructose and mannose metabolism"}
{"input": {"genes": ["GSTM5", "RRM2", "UGT2A2", "GSTM4", "CDA", "UGT1A6", "GSTO2", "UGT2B15", "NME6", "UGT1A7", "RRM2B", "UCK2", "GSTM1", "MGST3", "UCK1", "TPMT"], "cpd": ["5-FU", "Acetylhydrazine", "6-Mercaptopurine ribonucleoside 5'-diphosphate", "Carmofur (JP18/INN)", "5-Fluorouridine diphosphate", "5-Fluorodeoxyuridine", "Doxifluridine (JP18/INN)", "5-Fluorodeoxyuridine triphosphate", "Isonicotinoyl-NADP adduct", "Azathioprine (JP18/USP/INN)", "Isoniazid"]}, "target": "Drug metabolism - other enzymes"}
{"input": {"genes": ["GLYCTK", "PHGDH", "GNMT", "SHMT1", "PGAM2", "GRHPR", "ALAS1"], "cpd": ["Hydroxypyruvate", "Dihydrolipoylprotein", "L-Tryptophan", "L-Threonine", "L-Aspartate 4-semialdehyde", "Choline", "(R)-1-Aminopropan-2-ol", "D-Glycerate", "L-Cystathionine", "Methylglyoxal", "L-Serine", "Betaine", "5-Hydroxyectoine", "Betaine aldehyde", "L-Cysteine", "5,10-Methylenetetrahydrofolate", "3-Phospho-D-glycerate"]}, "target": "Glycine, serine and threonine metabolism"}
{"input": {"genes": ["ALDH3A2", "ALDH2", "UGT2B17", "UGT2B28", "UGDH", "GUSB", "UGT2B15", "UGT2B10", "RGN", "UGT1A7", "ALDH7A1", "UGT2B4", "UGT1A4", "MIOX", "KL", "UGT2B7", "UGT2A1"], "cpd": ["D-Galactarate", "D-Xylulose 5-phosphate", "D-Glucuronate", "L-Arabinono-1,4-lactone", "Ascorbate", "GDP-L-gulose", "L-Xylulose 5-phosphate", "L-Ascorbate 6-phosphate", "L-Galactono-1,5-lactone", "UDP-D-galacturonate", "D-Arabinonate", "L-Arabinonate", "D-Tagaturonate"]}, "target": "Ascorbate and aldarate metabolism"}
{"input": {"genes": ["ALDH1L1", "TYMS", "ATIC", "MTR", "DHFR2", "MTHFD1L", "SHMT2", "DHFR", "MTHFD2", "GART", "FTCD", "ALDH1L2", "MTHFD2L", "SHMT1", "MTHFD1", "ST20-MTHFS", "MTHFR", "AMT", "MTHFS", "MTFMT"], "cpd": ["5,10-Methylenetetrahydrofolate", "Tetrahydrofolate", "10-Formyltetrahydrofolate", "Folate", "Dihydrofolate", "5-Formiminotetrahydrofolate", "5-Methyltetrahydrofolate"]}, "target": "One carbon pool by folate"}
{"input": {"genes": ["PGM2", "ADH5", "ALDOC", "ENO3", "ALDOB", "ADH4"], "cpd": ["(S)-Lactate", "Pyruvate", "Glycerone phosphate", "Phosphoenolpyruvate", "beta-D-Glucose 6-phosphate", "Enzyme N6-(lipoyl)lysine", "alpha-D-Glucose", "Arbutin", "Salicin 6-phosphate", "2-(alpha-Hydroxyethyl)thiamine diphosphate", "Ethanol", "D-Fructose 6-phosphate", "2,3-Bisphospho-D-glycerate", "D-Fructose 1,6-bisphosphate", "beta-D-Glucose", "Acetaldehyde", "Acetate"]}, "target": "Glycolysis / Gluconeogenesis"}
{"input": {"genes": ["GLUD1", "NAGS", "GOT1", "ABHD14A-ACY1", "GLUL", "NOS2", "ASS1", "CPS1", "GOT1L1", "NOS3", "CAD", "GPT2", "ACY1", "GLUD2", "ASL"], "cpd": ["N-Acetylornithine", "CO2", "LysW-L-ornithine", "N-Acetyl-L-citrulline", "2-Oxoglutarate", "L-Glutamate", "Carbamoyl phosphate", "LysW-L-glutamate", "L-Aspartate", "N-Acetyl-L-glutamate", "Urea-1-carboxylate", "L-Ornithine", "Urea", "N-(L-Arginino)succinate", "N-Acetyl-L-glutamate 5-phosphate", "Ammonia", "L-Citrulline", "N-Acetyl-L-glutamate 5-semialdehyde", "L-Glutamine", "LysW-L-glutamate 5-semialdehyde", "Fumarate", "LysW-L-glutamyl 5-phosphate"]}, "target": "Arginine biosynthesis"}
{"input": {"genes": ["AK5", "PDE1B", "AK9", "APRT", "GUCY2C", "AK6", "ADSS1"], "cpd": ["Guanosine 3',5'-bis(diphosphate)", "alpha-D-Ribose 1-phosphate", "5'-Benzoylphosphoadenosine", "DNA", "Urate", "Guanosine 3'-phosphate", "N-Formiminoglycine", "HCO3-", "1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide"]}, "target": "Purine metabolism"}
{"input": {"genes": ["SQOR", "MPST"], "cpd": ["L-Serine", "Acetate", "Polysulfide", "Dimethyl sulfoxide", "Alkanesulfonate", "Protein-trisulfide", "3-(Methylthio)propanoyl-CoA"]}, "target": "Sulfur metabolism"}
{"input": {"genes": ["TALDO1", "ALDOA", "TKT", "SHPK", "RBKS", "IDNK", "RPIA", "TKTL1", "PGM2", "RPE", "GPI", "PRPS1L1", "TKTL2", "ALDOB", "ALDOC", "PRPS1", "RGN"], "cpd": ["5-Phospho-alpha-D-ribose 1-diphosphate", "D-Ribulose 5-phosphate", "D-Ribose 5-phosphate"]}, "target": "Pentose phosphate pathway"}
{"input": {"genes": ["AKR1A1", "RPE"], "cpd": ["CDP-ribitol", "Pectin", "3-Dehydro-L-gulonate", "D-Arabitol", "D-Xylulose", "UDP-glucuronate"]}, "target": "Pentose and glucuronate interconversions"}
{"input": {"genes": ["HADHA", "DLD", "INMT", "AOC1", "ALDH9A1", "AOX1", "IL4I1"], "cpd": ["7,8-Dihydroxykynurenate", "Formylanthranilate", "Indole-3-acetate", "4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate", "Formyl-N-acetyl-5-methoxykynurenamine", "N-Acetylisatin", "L-Formylkynurenine", "(Indol-3-yl)acetamide", "2-Oxoadipate", "Tryptamine", "(R)-(Indol-3-yl)lactate", "4-(2-Aminophenyl)-2,4-dioxobutanoate", "2-Formaminobenzoylacetate", "N-Methylserotonin", "Picolinic acid", "5-Methoxyindoleacetate", "Crotonoyl-CoA", "2-Aminomuconate semialdehyde", "Indole", "Indole-3-acetaldehyde oxime"]}, "target": "Tryptophan metabolism"}
{"input": {"genes": ["COX7C", "COX17", "NDUFAB1", "COX8A", "UQCRFS1", "ATP6V1H", "COX15", "ATP6AP1", "NDUFB9", "UQCR11", "UQCRH", "SDHD", "SDHB", "COX7A1", "MT-ATP6", "MT-ND6"], "cpd": ["ADP", "NADH", "Succinate", "H2O", "H+", "H+", "H2O", "Oxygen", "H+", "H+", "Fumarate", "H+", "NAD+", "Orthophosphate", "Triphosphate", "H+", "H+", "H+", "Diphosphate", "H+"]}, "target": "Oxidative phosphorylation"}
{"input": {"genes": ["", "DAO"], "cpd": ["Pyruvate", "Methylglyoxal", "L-Tryptophan", "Aminoacetone", "Tetrahydrofolate"]}, "target": "Glycine, serine and threonine metabolism"}
{"input": {"genes": ["GCK", "HK2"], "cpd": ["Butirosin B", "6'''-Deamino-6'''-hydroxyparomomycin II", "Tobramycin", "Neomycin C", "4-(gamma-L-Glutamylamino)butanoyl-[acp]", "Lividamine", "4'-Oxonebramine", "Xylostasin", "2'-Deamino-2'-hydroxy-6'-dehydroparomamine", "Kanamycin B", "Acyl-carrier protein", "Paromomycin II", "Nebramycin 5'", "6'''-Deamino-6'''-oxoneomycin C", "Nebramine", "2'-Deamino-2'-hydroxyneamine", "5'''-epi-Lividomycin B", "Gentamicin C2a", "3-Amino-2,3-dideoxy-scyllo-inosose", "4-Aminobutyryl-[acp]"]}, "target": "Neomycin, kanamycin and gentamicin biosynthesis"}
{"input": {"genes": ["FADS2", "ACAA1", "ACOX3", "PLA2G2A", "PLA2G6", "PLA2G4B", "PLA2G4D", "PLB1", "PLA2G12A"], "cpd": ["(9S,13S,15Z)-12-Oxo-10,11-dihydrophyto-15-enoate", "OPC4-CoA", "3-Oxo-OPC6-CoA", "(9Z,12Z,15Z)-Octadecatrienoic acid"]}, "target": "alpha-Linolenic acid metabolism"}
{"input": {"genes": ["PLCD3", "IPMK"], "cpd": ["myo-Inositol 4-phosphate", "D-myo-Inositol 1,2,4,5,6-pentakisphosphate", "1-Phosphatidyl-1D-myo-inositol 3-phosphate", "Acetyl-CoA", "Phosphatidylinositol-3,4,5-trisphosphate", "1,2-Diacyl-sn-glycerol", "1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "3-Dehydro-scyllo-inosose", "L-Bornesitol", "scyllo-Inositol", "2-Deoxy-5-keto-D-gluconic acid 6-phosphate", "1-Phosphatidyl-D-myo-inositol", "Bis(1L-myo-inositol)-3,1'-phosphate 1-phosphate", "D-myo-Inositol 1,4,5-trisphosphate", "D-Tagaturonate", "Glycerone phosphate", "Inositol 1-phosphate", "D-Bornesitol", "3D-3,5/4-Trihydroxycyclohexane-1,2-dione", "1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate", "D-Glyceraldehyde 3-phosphate", "1D-myo-Inositol 1,3,4-trisphosphate", "D-myo-Inositol 1,3-bisphosphate"]}, "target": "Inositol phosphate metabolism"}
{"input": {"genes": ["TAT", "GOT1", "GOT1L1", "GOT2", "IL4I1", "PAH"], "cpd": ["6-Deoxy-5-ketofructose 1-phosphate", "3-Hydroxybenzoate", "L-Aspartate 4-semialdehyde", "2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid", "Prephenate", "3,4-Dihydroxybenzoate", "2-Oxo-4-phenylbutyric acid", "L-Tyrosine"]}, "target": "Phenylalanine, tyrosine and tryptophan biosynthesis"}
{"input": {"genes": ["RPE", "UGT1A8", "KL", "UGT2B4", "UGT2A1", "UGT2A2", "SORD", "CRYL1", "AKR1A1", "UGT1A1", "UGT1A9", "UGT2B28", "AKR1B15"], "cpd": ["D-Xylonate", "D-Glucuronate 1-phosphate", "4-Deoxy-L-erythro-hex-4-enopyranuronate", "D-Galacturonate", "Glycerone phosphate", "Pectate", "L-Xylonate", "2-Dehydro-3-deoxy-D-gluconate"]}, "target": "Pentose and glucuronate interconversions"}
{"input": {"genes": ["TST", "LDHA", "MTAP", "SRM", "DNMT1", "GCLC", "DNMT3A", "AHCYL2", "GOT1L1", "CDO1", "PSAT1", "AGXT2", "DNMT3B", "CTH", "LDHAL6B", "GNMT", "GOT1", "BHMT", "AHCYL1", "MTR"], "cpd": ["L-Cysteate", "S-Methyl-5-thio-D-ribulose 1-phosphate", "S-Adenosyl-L-homocysteine", "O-Phospho-L-serine", "S-Adenosylmethioninamine", "(2R)-3-Sulfolactate", "S-Ribosyl-L-homocysteine", "Mercaptopyruvate", "3-Phosphonooxypyruvate", "2,3-Diketo-5-methylthiopentyl-1-phosphate", "4-Methylthio-2-oxobutanoic acid", "O-Acetyl-L-homoserine", "Ophthalmate", "1-Aminocyclopropane-1-carboxylate", "3-(Methylthio)propanoate", "HSO3-", "1-Deoxy-D-xylulose 5-phosphate", "2-Oxobutanoate", "L-Homocystine", "Methanethiol"]}, "target": "Cysteine and methionine metabolism"}
{"input": {"genes": ["ALDH3A2", "SETDB2", "ALDH1B1", "DLD", "ACAT2", "SETDB1", "SMYD1", "ALDH2", "EZH1", "SUV39H1", "SETMAR", "KMT5C", "SETD7", "AASS", "SMYD3", "KMT5B", "SETD1A", "HADHA", "SUV39H2", "PRDM7", "TMLHE"], "cpd": ["5-Acetamidopentanoate", "Carnitine", "L-2-Aminoadipate", "(2R,5S)-2,5-Diaminohexanoate", "Acetyl-CoA", "(S)-3-Hydroxybutanoyl-CoA", "Acetoacetate", "(S)-2,3,4,5-Tetrahydropyridine-2-carboxylate", "D-Lysine"]}, "target": "Lysine degradation"}
{"input": {"genes": ["SULT2B1", "UGT2B11", "UGT2B28", "UGT1A3", "AKR1D1", "HSD17B1", "UGT2B15", "CYP7A1"], "cpd": ["20alpha-Hydroxycholesterol", "5alpha-Pregnane-3alpha,20alpha-diol", "16alpha-Hydroxyestrone", "7alpha-Hydroxytestosterone", "7alpha-Hydroxypregnenolone", "Dihydrotestosterone", "Estriol", "2-Hydroxyestradiol", "5alpha-Pregnan-20alpha-ol-3-one", "2-Methoxyestrone 3-sulfate", "2-Methoxyestrone", "2-Hydroxyestrone", "Cortisone", "16-Glucuronide-estriol", "Cortol", "Etiocholanolone", "Pregnenolone", "Testololactone", "11-Dehydrocorticosterone", "5beta-Dihydrotestosterone", "Allotetrahydrodeoxycorticosterone"]}, "target": "Steroid hormone biosynthesis"}
{"input": {"genes": ["PLCG1", "PIK3CG", "PLCB4", "ITPKB", "MTMR2", "INPP5F", "MTMR1", "PTEN", "PIP4K2B", "PLCB1", "SYNJ2", "MINPP1", "PLCZ1", "FIG4", "PIK3C3", "INPP5B", "PI4K2A", "PIK3CD", "PIP4K2A", "INPP5J", "ALDH6A1", "PLCG2"], "cpd": ["2,4,6/3,5-Pentahydroxycyclohexanone", "1-Phosphatidyl-1D-myo-inositol 4-phosphate", "3-Oxopropanoate", "1-Phosphatidyl-D-myo-inositol", "CDP-1L-myo-inositol", "D-Glucuronate", "Phosphatidylinositol-3,4,5-trisphosphate", "D-myo-Inositol 1,4,5-trisphosphate", "1D-myo-Inositol 1,4,5,6-tetrakisphosphate", "1D-myo-Inositol 1,3,4,6-tetrakisphosphate", "D-Glyceraldehyde 3-phosphate", "1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate", "5-Dehydro-L-gluconate", "1D-myo-Inositol 1,3,4-trisphosphate", "3D-3,5/4-Trihydroxycyclohexane-1,2-dione", "1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "2-Deoxy-5-keto-D-gluconic acid", "Inositol 1,2,3,5,6-pentakisphosphate", "1-Phosphatidyl-1D-myo-inositol 5-phosphate", "Acetyl-CoA"]}, "target": "Inositol phosphate metabolism"}
{"input": {"genes": ["ASNS", "ACO2", "PFKM", "ACY1", "TPI1", "MTR", "PHGDH"], "cpd": ["N-Acetyl-L-citrulline", "L-Aspartate 4-semialdehyde", "S-Ribosyl-L-homocysteine", "N-Succinyl-2-L-amino-6-oxoheptanedioate", "L-Cystathionine", "3-(Imidazol-4-yl)-2-oxopropyl phosphate", "3-(4-Hydroxyphenyl)pyruvate", "L-Threonine", "L-Glutamine"]}, "target": "Biosynthesis of amino acids"}
{"input": {"genes": ["NDUFA13", "UQCRC1", "NDUFA7", "COX6C", "COX6B1"], "cpd": ["H+", "H+", "Succinate", "NADH", "H+", "NAD+"]}, "target": "Oxidative phosphorylation"}
{"input": {"genes": ["ADH1B", "GSTA4", "CYP1A2", "CYP2D7", "UGT1A4", "GSTA2", "CYP2E1", "UGT2A3", "ADH1A", "ADH4", "UGT2A2", "CYP2A6", "GSTA5", "MGST3", "FMO3", "ADH6", "GSTA3", "MGST1", "FMO2", "MAOA", "CYP2C8", "CYP2A7", "UGT1A10"], "cpd": ["Carbamazepine-10,11-epoxide", "Isophosphoramide mustard", "Levomethadyl acetate (USAN)"]}, "target": "Drug metabolism - cytochrome P450"}
{"input": {"genes": ["ALOX15", "PTGDS", "PTGR3", "LTA4H", "GGT1", "EPHX2", "PLA2G5", "TBXAS1", "PLA2G10", "CYP2E1", "PLA2G12A", "PLA2G2D", "PTGES2", "HPGD", "ALOX15B", "PLA2G4A", "PLA2G4F"], "cpd": ["Hepoxilin B3", "Hepoxilin A3", "Leukotriene D4", "(5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate", "Prostaglandin E2", "Trioxilin B3", "11-Dehydro-thromboxane B2", "9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid", "11,12,15-THETA", "8(R)-HPETE", "Prostaglandin B2", "Leukotriene C4", "5-OxoETE", "Prostaglandin D2", "(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate", "(5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate", "5(S)-HETE", "12(S)-HETE"]}, "target": "Arachidonic acid metabolism"}
{"input": {"genes": ["AGL", "GYG2", "PGM2L1"], "cpd": ["Maltodextrin", "Maltose 6'-phosphate", "Dextran", "D-Fructose 6-phosphate", "alpha,alpha-Trehalose", "alpha-D-Glucose 1,6-bisphosphate", "Isomaltose", "Cellobiose", "D-Glucose 6-phosphate", "Sucrose", "Sucrose 6-phosphate", "GDP-glucose", "Amylose", "D-Fructose", "Sucrose 6'-phosphate", "Maltose", "Amylose", "D-Glucose", "Cellobiose", "3-Ketosucrose", "UDP-glucose", "Dextran", "D-Glucose 1-phosphate", "Sucrose"]}, "target": "Starch and sucrose metabolism"}
{"input": {"genes": ["G6PC3", "GANC", "MGAM2", "SI", "GCK", "AMY1B", "PGM1", "GYS2", "HK3", "PGM2L1", "GYG1", "GPI"], "cpd": ["beta-D-Glucose 1-phosphate", "1,3-beta-D-Glucan", "Cellodextrin", "Maltodextrin", "Cellobiose", "D-Glucose 6-phosphate", "alpha,alpha'-Trehalose 6-phosphate", "Dextran", "D-Glucose", "D-Glucose", "6-Phospho-beta-D-glucosyl-(1,4)-D-glucose", "Sucrose 6'-phosphate", "D-Glucose 6-phosphate", "D-Glucose", "Maltose", "UDP-glucose", "Starch", "alpha-D-Glucose 1,6-bisphosphate", "Cyclomaltodextrin", "1-alpha-D-[(1->4)-alpha-D-Glucosyl](n-1)-alpha-D-glucopyranoside", "D-Fructose", "Sucrose"]}, "target": "Starch and sucrose metabolism"}
{"input": {"genes": ["HKDC1", "AMDHD2", "PMM2"], "cpd": ["UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose", "alpha-D-Galactose", "D-Glucose 1-phosphate", "alpha-D-Glucose", "ADP-glucose", "D-Fructose", "UDP-glucuronate", "D-Glucosamine", "UDP-N,N'-diacetylbacillosamine", "alpha-D-Glucose 6-phosphate", "2,4-Diacetamido-2,4,6-trideoxy-D-mannopyranose", "N,N'-Diacetyllegionaminate", "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate", "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "N-Acetyl-alpha-D-glucosamine 1-phosphate", "Chitin", "D-Mannose", "N-Acetylmuramate", "UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "D-Xylose", "GDP-6-deoxy-D-mannose", "UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose", "N-Acetylmuramic acid alpha-1-phosphate", "D-Glucose", "N-Acetyl-D-mannosamine"]}, "target": "Amino sugar and nucleotide sugar metabolism"}
{"input": {"genes": ["GLCE", "NDST2", "NDST3", "HS3ST2"], "cpd": ["Acetate", "Adenosine 3',5'-bisphosphate", "[Protein]-L-serine"]}, "target": "Glycosaminoglycan biosynthesis - heparan sulfate / heparin"}
{"input": {"genes": ["ITPA", "GSTM3", "UCK1"], "cpd": ["5-Fluorodeoxyuridine", "NADP+"]}, "target": "Drug metabolism - other enzymes"}
{"input": {"genes": ["UGT1A3", "EPRS1", "HEPHL1", "ALAS1", "HEPH", "HMBS"], "cpd": ["Precorrin 2", "Primary fluorescent chlorophyll catabolite", "Biliverdin", "Cobamide coenzyme", "7(1)-Hydroxychlorophyllide a", "Fe-coproporphyrin III", "Dimethylbenzimidazole", "Sirohydrochlorin", "Hemoglobin", "Bacteriochlorophyll c", "Cobalt-sirohydrochlorin", "Coproporphyrin I", "Cob(I)yrinate a,c diamide", "3-Vinylbacteriochlorophyllide a", "Nickel-sirohydrochlorin a,c-diamide", "Cob(I)alamin"]}, "target": "Porphyrin metabolism"}
{"input": {"genes": ["CHSY3", "CSGALNACT1", "DSE", "CHST11", "CHST12", "CSGALNACT2", "B4GALT7", "CHST14", "DSEL", "XYLT1", "CHST3", "XYLT2"], "cpd": ["Dermatan", "[Protein]-L-serine", "Adenosine 3',5'-bisphosphate", "Chondroitin", "3'-Phosphoadenylyl sulfate", "Adenosine 3',5'-bisphosphate", "3'-Phosphoadenylyl sulfate"]}, "target": "Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate"}
{"input": {"genes": ["PLA2G7", "PLD2", "GAL3ST1", "PLA2G3", "PLA2G4E", "PLAAT3", "PAFAH1B3", "JMJD7-PLA2G4B", "AGPS", "LPCAT4", "SELENOI"], "cpd": ["1-Alkyl-2-acetyl-sn-glycerol", "Galactosyl-1-alkyl-2-acylglycerol", "sn-Glycero-3-phosphocholine", "1-Alkyl-2-acylglycerophosphoethanolamine", "1-Alkyl-2-acylglycerol", "2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine", "O-Alkylglycerone phosphate", "1-Alkenyl-2-acylglycerol", "1-(1-Alkenyl)-sn-glycero-3-phosphate", "1-Organyl-2-lyso-sn-glycero-3-phosphocholine", "2-Acyl-1-alkyl-sn-glycero-3-phosphate", "2-Acetyl-1-alkyl-sn-glycero-3-phosphate", "1-Alkyl-sn-glycerol", "1-O-Alkyl-2-acetyl-3-acyl-sn-glycerol", "1-(1-Alkenyl)-sn-glycero-3-phosphoethanolamine", "1-Radyl-2-acyl-sn-glycero-3-phosphocholine", "1-Alkyl-sn-glycero-3-phosphate", "Acylglycerone phosphate", "2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphate", "1-(1-Alkenyl)-sn-glycero-3-phosphocholine", "sn-Glycero-3-phosphoethanolamine", "O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine", "Seminolipid"]}, "target": "Ether lipid metabolism"}
{"input": {"genes": ["ABO", "HEXB", "FUT2", "FUT9", "B3GALNT1", "ST3GAL1", "NAGA", "A3GALT2", "A4GALT", "ST3GAL2", "B3GALT5", "FUT1"], "cpd": ["Forssman antigen, IV3GalNAca-Gb4Cer", "NORint", "Lactosylceramide", "Monosialylgalactosylgloboside", "IV4-alpha-Gal-Gb4Cer", "Globotriaosylceramide", "Globoside", "Galactosylgloboside", "Globo-B", "IV3GalNAcb-Gb4Cer", "iGb3-Cer", "NOR2 antigen", "iGb4-Cer", "V3(NeuAc)2-Gb5Cer", "Disialosylglobopentaosylceramide", "GalGb3Cer", "Globo-A", "Globo-H"]}, "target": "Glycosphingolipid biosynthesis - globo and isoglobo series"}
{"input": {"genes": ["LPCAT2", "ETNPPL", "PLA2G4C", "PLA2G12A", "MBOAT2", "LCAT", "PLA2G4F", "CHAT", "PLA2G2D", "DGKB", "PLD1", "LPGAT1", "ACHE", "PCYT2", "PTDSS1", "GPAT3"], "cpd": ["Acyl-CoA", "sn-Glycerol 1-phosphate", "Ethanolamine", "2-Acyl-sn-glycero-3-phosphocholine", "CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol", "Phosphatidyl-N-dimethylethanolamine", "1-Acylglycerophosphoinositol", "Heptaprenylglycerol", "Diethanolamine", "CDP-glycerol", "3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate", "sn-Glycerol 3-phosphate", "2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine", "1,2-Diacyl-sn-glycerol", "Aminoacyl-phosphatidylglycerol", "2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate", "L-Serine-phosphoethanolamine", "sn-Glycerol 3-phosphate", "Triethanolamine"]}, "target": "Glycerophospholipid metabolism"}
{"input": {"genes": ["PLA2G2D", "PLAAT2", "PLA2G6", "ACOX1"], "cpd": ["Traumatic acid", "(+)-7-Isojasmonic acid", "13(S)-HPOT", "2(R)-HOT", "(+)-7-Isomethyljasmonate", "3,6-Nonadienal", "Heptadecatrienal", "(9S,13S,15Z)-12-Oxo-10,11-dihydrophyto-15-enoate", "Stearidonic acid", "Colnelenic acid", "(+)-7-Isojasmonic acid CoA", "OPC8-CoA", "3-Oxo-OPC4-CoA", "Norlinolenic acid", "Etherolenic acid", "9-Hydroxy-12-oxo-10(E),15(Z)-octadecadienoic acid", "9(S)-HOT", "9-Oxononanoic acid", "12-Oxo-9(Z)-dodecenoic acid", "9,10-EOT", "3-Hexenal", "9(S)-HPOT", "OPC6-CoA", "trans-2-Enoyl-OPC6-CoA", "3-Hexenol"]}, "target": "alpha-Linolenic acid metabolism"}
{"input": {"genes": ["ST6GALNAC5", "GLB1", "ST6GALNAC6"], "cpd": ["GD1c", "GQ1c", "GM2alpha", "GT1aalpha", "N-Acetylgalactosaminyl GM1b", "Lactosylceramide", "GT3", "GM1alpha", "GT1b", "GM1b", "Fucosyl-GM1", "GD3", "GD2", "GD1b", "9-O-Acetylated GD3", "GP1c", "GD1beta", "GT2", "GA1", "GT1a", "GM3"]}, "target": "Glycosphingolipid biosynthesis - ganglio series"}
{"input": {"genes": ["BPNT2", "SELENBP1", "BPNT1", "PAPSS2", "MPST", "SUOX", "PAPSS1", "ETHE1", "TST", "SQOR"], "cpd": ["Sulfite", "Thiosulfate", "Trithionate", "Alkanesulfonate", "Succinate", "3-(Methylthio)propanoate", "L-Homocysteine", "L-Homoserine", "3'-Phosphoadenylyl sulfate", "Tetrathionate", "2-(Methylthio)ethanesulfonate", "Polysulfide", "Sulfate", "O-Acetyl-L-serine", "Sulfate", "L-Cysteine", "Dimethyl sulfone", "Sulfur", "S,S-Dimethyl-beta-propiothetin", "Alkanesulfonate"]}, "target": "Sulfur metabolism"}
{"input": {"genes": ["COMT", "AOC3", "DDC", "ADH1B", "TAT", "AOX1", "FAH", "IL4I1", "ALDH3B1", "ALDH3A1", "ALDH3B2", "GOT1", "ADH6", "DBH", "MAOB"], "cpd": ["Hydroquinone", "4-Fumarylacetoacetate", "4-Hydroxyphenylacetylglutamic acid", "Dopamine", "4-Hydroxyphenylethanol", "3,4-Dihydroxyphenylacetaldehyde", "(R)-3-(4-Hydroxyphenyl)lactate", "5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde"]}, "target": "Tyrosine metabolism"}
{"input": {"genes": ["ENPP2", "ENPP6", "PLAAT3", "GDPD1", "PLD4", "LPCAT2", "PLA2G2A", "PLPP1", "PLA2G2E", "PLA2G6", "PLA2G4B", "PLA2G4E", "AGPS", "PLAAT2", "PLA2G12B", "LPCAT4", "PLD3", "PLD1", "GDPD3", "TMEM86B"], "cpd": ["1-Alkyl-sn-glycero-3-phosphate", "2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphate", "1-(1-Alkenyl)-sn-glycerol"]}, "target": "Ether lipid metabolism"}
{"input": {"genes": ["GLA", "PFKP", "GALK1", "LCT", "GALT", "HKDC1", "MGAM", "PGM1", "HK3", "G6PC3", "GANC", "HK1", "B4GALT2", "PFKM", "GLB1", "GALE", "MGAM2", "UGP2", "G6PC1", "LALBA"], "cpd": ["Melibiose", "Stachyose", "D-Glyceraldehyde 3-phosphate", "D-Galactose", "alpha-D-Glucose", "D-Galactose 6-phosphate", "Epimelibiose", "D-Galactosamine"]}, "target": "Galactose metabolism"}
{"input": {"genes": ["ACSBG1", "HSD17B8", "ACSBG2", "ACACB", "ACSL3", "MECR", "HTD2", "ACSF3", "OXSM", "FASN", "ACSL1", "ACACA", "ACSL5", "OLAH", "MCAT", "CBR4", "ACSL6", "ACSL4"], "cpd": ["Oleoyl-[acyl-carrier protein]", "Butyryl-[acp]", "Octanoic acid", "Acetyl-CoA", "Long-chain acyl-CoA", "Acetyl-CoA", "Octanoyl-[acp]", "Hexadecenoyl-[acyl-carrier protein]", "Octadecanoic acid", "Acyl-[acyl-carrier protein]", "trans-Tetradec-2-enoyl-[acp]", "Acyl-carrier protein"]}, "target": "Fatty acid biosynthesis"}
{"input": {"genes": ["HOGA1", "NOS2", "AGMAT", "LAP3", "CKMT1A", "CKMT2", "CKB", "SMS", "ALDH7A1", "GOT1L1", "ALDH1B1", "GAMT", "SAT2", "CKMT1B", "PYCR1", "ARG1", "CKM", "NOS1"], "cpd": ["4-(L-gamma-Glutamylamino)butanoate", "N2-Succinyl-L-arginine", "Urea", "N-Succinyl-L-glutamate", "(4R)-4-Hydroxy-2-oxoglutarate", "D-Proline"]}, "target": "Arginine and proline metabolism"}
{"input": {"genes": ["NTPCR", "RRM2", "GUCY1A2", "AK9", "PDE3A", "ADCY9", "AK6", "DGUOK", "PDE6A", "ENTPD3", "NME1", "PDE1A", "PDE6G", "NT5C", "PDE4D", "PAPSS1", "GMPR2", "PDE1C", "ADCY10"], "cpd": ["(R)(-)-Allantoin", "XTP", "2',3'-Cyclic AMP"]}, "target": "Purine metabolism"}
{"input": {"genes": ["CYP4F8", "CYP2U1", "CBR1", "PLA2G2E", "AKR1C3", "CYP2C9", "PTGR3", "CYP2B6", "PTGS1", "GGT5", "PTGIS", "CYP2E1", "PLA2G4E", "CBR3"], "cpd": ["8,9-DHET", "15H-11,12-EETA", "Hepoxilin A3", "(5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate", "Leukotriene B4", "Arachidonate", "11(R)-HETE"]}, "target": "Arachidonic acid metabolism"}
{"input": {"genes": ["NADK", "PTS", "SHMT2", "GCLM", "RDH11", "DHRS3", "LIPT1", "CMPK2", "NADK2", "PDXP", "UGT2A2", "ALAS2", "HAAO", "UGT1A10", "IDO1", "EPRS1", "KYNU", "PPCDC", "QPRT", "NME1-NME2", "MPI"], "cpd": ["UTP", "(8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate", "Nicotinate", "Thiocarboxy-[sulfur-carrier protein]", "CDP"]}, "target": "Biosynthesis of cofactors"}
{"input": {"genes": ["PLAAT2", "PLA2G12A", "CYP1A2", "ALOX15", "PLA2G2A", "PLA2G2F", "PLA2G5", "PLA2G4B", "PLA2G10", "PLA2G2E", "PLA2G4E", "PLA2G4F", "CYP3A4", "PLA2G4A", "PLA2G1B", "CYP2J2", "PLA2G2C", "CYP2C8", "CYP2E1", "PLAAT3", "PLA2G12B", "JMJD7-PLA2G4B", "PLB1", "PLA2G3"], "cpd": ["(7S,8S)-DiHODE", "(6Z,9Z,12Z)-Octadecatrienoic acid", "(9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid", "9,10,13-TriHOME", "12,13-Epoxy-9-hydroxy-10-octadecenoate", "Arachidonate", "9(S)-HPODE", "9,12,13-TriHOME", "12(13)-EpOME", "12,13-DHOME", "12,13-Epoxy-9-hydroxy-10-octadecenoate", "(9Z,11E)-12-[(1E)-Hex-1-en-1-yloxy]dodeca-9,11-dienoic acid", "Crepenynate", "Rumenic acid", "(9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid", "9,12,13-TriHOME", "13-OxoODE", "(8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate"]}, "target": "Linoleic acid metabolism"}
{"input": {"genes": ["PDXK", "AOX1", "PSAT1"], "cpd": ["D-Ribose 5-phosphate", "D-Glyceraldehyde 3-phosphate", "Pyridoxine", "Pyridoxine phosphate", "4-Pyridoxolactone", "2-(Hydroxymethyl)-4-oxobutanoate", "2-(Hydroxymethyl)-3-(acetamidomethylene)succinate", "5-Pyridoxolactone"]}, "target": "Vitamin B6 metabolism"}
{"input": {"genes": ["CHSY1", "CHST13", "DSE", "CHST12", "CHST15", "DSEL", "CHSY3", "XYLT1", "CHST3", "CSGALNACT1", "B4GALT7", "CSGALNACT2"], "cpd": ["Adenosine 3',5'-bisphosphate", "3'-Phosphoadenylyl sulfate", "Dermatan", "[Protein]-L-serine", "Adenosine 3',5'-bisphosphate", "Chondroitin", "3'-Phosphoadenylyl sulfate"]}, "target": "Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate"}
{"input": {"genes": ["GM2A", "ENPP7"], "cpd": ["Sphingomyelin", "GM4", "Sphingosine 1-phosphate", "Sphingosyl-phosphocholine", "Galactosylceramide", "GM3", "Globoside", "Digalactosylceramide"]}, "target": "Sphingolipid metabolism"}
{"input": {"genes": ["BCKDHB", "BCKDHA", "LIPT1", "AMT", "LIPT2", "DLAT", "", "DLD", "GCSH", "GLDC", "DHTKD1", "OGDHL"], "cpd": ["Lipoylprotein", "3-Methylbutanoyl-CoA", "2-Methylpropanoyl-CoA", "Enzyme N6-(dihydrolipoyl)lysine", "(S)-3-Methyl-2-oxopentanoic acid", "Octanoyl-CoA", "[Protein]-S8-aminomethyldihydrolipoyllysine", "5,10-Methylenetetrahydrofolate", "Dihydrolipoate", "Enzyme N6-(dihydrolipoyl)lysine", "Pyruvate", "4-Carboxy-1-hydroxybutyryl-ThPP", "[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine", "Thiamin diphosphate", "Succinyl-CoA", "Glycine", "2-Methyl-1-hydroxypropyl-ThPP", "3-Methyl-1-hydroxybutyl-ThPP", "Acetyl-CoA", "Enzyme N6-(lipoyl)lysine", "2-Oxoglutarate", "Dihydrolipoylprotein"]}, "target": "Lipoic acid metabolism"}
{"input": {"genes": ["XDH", "CYP2A6", "CYP1A2"], "cpd": ["5-Acetylamino-6-amino-3-methyluracil", "3-Methylxanthine", "7-Methyluric acid", "Caffeine", "Theophylline", "N-Methylurea", "1,3,7-Trimethyl-5-hydroxyisourate", "7-Methylxanthosine", "3,7-Dimethyluric acid", "Xanthine", "N,N'-Dimethylurea", "1,7-Dimethyluric acid", "Xanthosine"]}, "target": "Caffeine metabolism"}
{"input": {"genes": ["NT5C3B", "AK9", "NME1-NME2", "NME2", "CTPS1", "NT5E", "TK1", "ENTPD6", "UCKL1", "NME3", "DUT", "ASMTL", "ENTPD1", "HDDC2", "DCTPP1", "UPP1", "DHODH", "TYMP", "NUDT2"], "cpd": ["Cytosine", "2',3'-Cyclic CMP", "dUMP"]}, "target": "Pyrimidine metabolism"}
{"input": {"genes": ["ACSS2", "ADH5", "ALDH7A1", "DLD", "PKM", "ALDH3A2", "ADH7", "PDHA2", "LDHAL6B", "ACOT12", "ACACA", "DLAT"], "cpd": ["alpha-Isopropylmalate", "(R)-Lactate", "(R)-Lactaldehyde", "Enzyme N6-(dihydrolipoyl)lysine", "Methylglyoxal", "Oxaloacetate", "Acetaldehyde", "2-Hydroxyethylenedicarboxylate", "Thiamin diphosphate", "(R)-2-Hydroxybutane-1,2,4-tricarboxylate", "(R)-S-Lactoylglutathione", "(S)-Lactaldehyde", "(S)-Malate", "Enzyme N6-(lipoyl)lysine", "Acetate", "[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine", "Phosphoenolpyruvate", "Acetoacetyl-CoA", "Acetyl-CoA", "(R)-2-Ethylmalate", "2-Propylmalate", "Acetylenedicarboxylate", "Pyruvate"]}, "target": "Pyruvate metabolism"}
{"input": {"genes": ["CHIA", "FCSK", "RENBP", "GMPPB", "GMPPA", "UGDH", "GCK", "UXS1", "NANP", "GALT", "", "GALE", "HK3", "PGM1"], "cpd": ["D-Mannose", "UDP-6-sulfoquinovose", "Chitin", "UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose", "UDP-D-xylose", "UDP-L-arabinose", "UDP-alpha-D-galactose", "UDP-N-acetyl-D-mannosamine", "L-Fucose 1-phosphate", "alpha-D-Arabinopyranose 1-phosphate", "GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose", "D-Mannose 1-phosphate", "D-Arabinose", "GDP-D-arabinopyranose", "N-Acetyl-D-glucosamine", "N-Acetylneuraminate 9-phosphate", "GDP-D-mannuronate", "Chitosan", "D-Galactosamine 6-phosphate", "N-Acetyl-D-glucosamine", "D-Glucose", "UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate"]}, "target": "Amino sugar and nucleotide sugar metabolism"}
{"input": {"genes": ["PCYT1B", "PCYT1A", "CHPT1", "CEPT1", "SELENOI", "PCYT2"], "cpd": ["Rhizocticin B", "Ceramide 2-aminoethylphosphonate", "CMP-2-aminoethylphosphonate", "Demethylphosphinothricin", "2-Oxo-4-phosphonobutanoate", "Phosphonoacetaldehyde", "Phosphonoformate"]}, "target": "Phosphonate and phosphinate metabolism"}
{"input": {"genes": ["ALDH2", "P4HA1", "ALDH7A1", "DAO", "MAOA", "CKMT1B", "GAMT", "AGMAT", "ARG2", "HOGA1", "LAP3", "ARG1", "GOT1", "PRODH2"], "cpd": ["N1-[(S)-3-amino-3-carboxypropyl]agmatine", "Sarcosine", "Octopine", "L-Arginine", "4-(L-gamma-Glutamylamino)butanoate", "Peptide", "D-Proline", "1-Pyrroline-2-carboxylate", "5-Aminopentanoate", "N(omega)-Hydroxyarginine", "Phosphocreatine", "1,3-Diaminopropane", "N-Succinyl-L-glutamate", "N4-Acetylaminobutanal", "gamma-Glutamyl-gamma-aminobutyraldehyde"]}, "target": "Arginine and proline metabolism"}
{"input": {"genes": ["FMO3", "GGT1", "GGT6", "FMO4", "GAD1", "FMO5", "BAAT", "FMO2", "GGT5", "CSAD", "GGT7", "CDO1"], "cpd": ["Sulfoacetate", "Cysteamine", "L-Cysteate", "Taurocholate", "Sulfoacetaldehyde"]}, "target": "Taurine and hypotaurine metabolism"}
{"input": {"genes": ["SDS", "SDSL"], "cpd": ["(S)-3-Methyl-2-oxopentanoic acid", "(2R,3S)-3-Isopropylmalate", "2-Oxobutanoate", "D-erythro-3-Methylmalate", "3-Hydroxy-3-methyl-2-oxobutanoic acid", "alpha-Isopropylmalate", "L-Leucine", "(R)-3-Hydroxy-3-methyl-2-oxopentanoate", "(R)-2,3-Dihydroxy-3-methylbutanoate", "L-Threonine", "(R)-2-Methylmalate", "4-Methyl-2-oxopentanoate", "2-Methylmaleate", "Acetyl-CoA", "Pyruvate", "2-Isopropylmaleate", "L-Isoleucine"]}, "target": "Valine, leucine and isoleucine biosynthesis"}
{"input": {"genes": ["COQ6", "COQ2", "COQ3", "HPD"], "cpd": ["Cyclic dehypoxanthine futalosine", "2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate", "4-Coumarate", "Shikonin", "3,4-Dihydroxy-5-polyprenylbenzoate", "Demethylphylloquinol", "3-Demethylubiquinol", "(1R,6R)-6-Hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate", "Geranyl diphosphate", "3''-Hydroxy-geranylhydroquinone", "Geranylgeranyl diphosphate", "4-(beta-D-Glucosyloxy)benzoate", "beta-Tocopherol", "6-Geranylgeranyl-2,3-dimethylbenzene-1,4-diol", "p-Coumaroyl-CoA", "Vitamin K1 epoxide", "Homogentisate", "gamma-Tocotrienol", "delta-Tocotrienol", "3-[(1-Carboxyvinyl)oxy]benzoate", "1,4-Dihydroxy-6-naphthoate", "Chorismate", "Futalosine", "all-trans-Polyprenyl diphosphate", "2-Methyl-6-phytylquinol"]}, "target": "Ubiquinone and other terpenoid-quinone biosynthesis"}
{"input": {"genes": ["GCNT1", "GALNT3", "B3GNT6", "ST3GAL1", "ST6GALNAC4", "GALNT13", "B3GNT3", "GALNT10", "GALNTL5", "POC1B-GALNT4", "GALNT9", "GALNTL6", "GALNT2", "GALNT4", "C1GALT1C1", "GALNT6", "GALNT8", "GALNT15", "GALNT5"], "cpd": ["UDP-N-acetyl-D-galactosamine", "[Protein]-L-serine"]}, "target": "Mucin type O-glycan biosynthesis"}
{"input": {"genes": ["CA4", "CA1", "CA12", "CA2", "GLUD1", "CA13", "CA3", "CPS1", "CA9", "CA5A", "GLUD2", "CA7"], "cpd": ["Ammonia", "Nitrate", "Nitric oxide", "Nitrous oxide", "Nitric oxide", "Nitrite", "Nitrite", "Formate", "L-Glutamine", "Carbamoyl phosphate", "Hydrazine", "Nitrate", "Nitrile", "HCO3-", "Nitrate"]}, "target": "Nitrogen metabolism"}
{"input": {"genes": ["GATB", "YARS2", "LARS2", "WARS1", "DARS1", "MT-TQ", "MT-TF", "RARS1"], "cpd": ["L-Cysteinyl-tRNA(Cys)", "L-Pyrrolysyl-tRNA(Pyl)", "L-Methionyl-tRNA", "L-Valine", "L-Asparaginyl-tRNA(Asn)", "10-Formyltetrahydrofolate", "L-Lysine", "Tetrahydrofolate", "L-Histidyl-tRNA(His)", "L-Phenylalanyl-tRNA(Phe)"]}, "target": "Aminoacyl-tRNA biosynthesis"}
{"input": {"genes": ["CPOX", "AK4", "COQ5", "HMBS", "NME2", "BCAT1"], "cpd": ["4-Amino-5-hydroxymethyl-2-methylpyrimidine", "3-Dehydroshikimate", "Cobalt-factor III", "Precorrin 4", "Adenosyl cobinamide phosphate", "3-Hydroxyanthranilate", "Homoisocitrate", "beta-Alanine", "CDP", "Pimeloyl-[acyl-carrier protein] methyl ester", "3-Hydroxy-L-kynurenine", "4-Methyl-5-(2-phosphooxyethyl)thiazole", "Dihydrolipoylprotein", "Cobalt-sirohydrochlorin", "L-Gulonate", "Acetyl-CoA", "Cobalt-precorrin 4", "Molybdoenzyme molybdenum cofactor", "(2R)-O-Phospho-3-sulfolactate", "Retinol", "L-Kynurenine", "Precorrin 2"]}, "target": "Biosynthesis of cofactors"}
{"input": {"genes": ["UGT1A5", "HSD17B6", "DHRS9", "CYP2W1", "UGT1A10", "ALDH1A1", "RDH8", "UGT1A9", "CYP3A5", "ADH6", "UGT1A1", "UGT2A3", "UGT2B17", "DHRS4L2", "CYP2C18", "AWAT2", "CYP1A2", "UGT2B28", "AOX1", "RDH10", "CYP3A4", "DGAT1", "UGT1A7", "DHRS3"], "cpd": ["all-trans-4-Oxoretinoic acid", "Retinal", "11-cis-Retinyl palmitate", "all-trans-4-Hydroxyretinoic acid", "all-trans-Retinoyl-beta-glucuronide", "all-trans-18-Hydroxyretinoic acid", "Iodopsin", "Lumirhodopsin", "11-cis-Retinal", "11-cis-Retinol", "Retinoate", "all-trans-3,4-Didehydroretinol", "Bathorhodopsin", "4-Oxoretinol", "Rhodopsin", "Metarhodopsin"]}, "target": "Retinol metabolism"}
{"input": {"genes": ["TPK1", "AK8", "ALPI", "AK7", "AK1"], "cpd": ["D-Glyceraldehyde 3-phosphate", "ADP-5-ethyl-4-methylthiazole-2-carboxylate"]}, "target": "Thiamine metabolism"}
{"input": {"genes": ["ACSF3", "ACSL6", "CBR4", "ACACB", "MECR", "HSD17B8", "OLAH", "ACSL5", "ACSL4", "FASN", "OXSM", "ACACA", "MCAT", "ACSBG1", "HTD2", "ACSBG2"], "cpd": ["(3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]", "(3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]", "trans-Hex-2-enoyl-[acp]", "(3R)-3-Hydroxyacyl-[acyl-carrier protein]", "(3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]", "Acetoacetyl-[acp]", "Octanoic acid", "(3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]", "Acyl-[acyl-carrier protein]", "Malonyl-CoA", "Octadecanoic acid", "Acetyl-CoA", "Long-chain acyl-CoA", "Octadecanoyl-[acyl-carrier protein]", "Malonyl-[acyl-carrier protein]", "cis-Dec-3-enoyl-[acp]", "3-Oxohexadecanoyl-[acp]", "Tetradecanoyl-[acp]", "3-Oxotetradecanoyl-[acp]", "Acetyl-CoA", "Acetyl-CoA", "n-7 Unsaturated acyl-[acyl-carrier protein]"]}, "target": "Fatty acid biosynthesis"}
{"input": {"genes": ["CYP24A1", "CYP51A1", "LBR", "HSD17B7", "LIPA", "SOAT2", "SOAT1", "CYP27B1", "CEL", "LSS", "NSDHL", "MSMO1", "SC5D", "DHCR24", "EBP", "DHCR7", "FDFT1", "CYP2R1", "SQLE"], "cpd": ["Calcitetrol", "Episterol", "trans,trans-Farnesyl diphosphate", "Delta7-Avenasterol", "Fecosterol", "Isofucosterol", "4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol", "Obtusifoliol", "Vitamin D3", "Lathosterol", "4alpha-Methylzymosterol", "Presqualene diphosphate", "Calcidiol", "24-epi-Campesterol", "Cycloartenol", "4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol", "4alpha-Methylfecosterol", "3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate", "7-Dehydrodesmosterol", "24,25-Dihydrolanosterol", "5-Dehydroepisterol", "5alpha-Cholesta-7,24-dien-3beta-ol", "Zymosterone"]}, "target": "Steroid biosynthesis"}
{"input": {"genes": ["DGLUCY", "SRR"], "cpd": ["Hydroxyproline", "meso-2,6-Diaminoheptanedioate", "Pyruvate", "D-Serine", "2-Amino-4-oxopentanoic acid", "(2R,4S)-2,4-Diaminopentanoate", "4-Methylthio-2-oxobutanoic acid", "D-Glutamine", "D-Cysteine", "5-Aminopentanoate", "L-Glutamine", "Cadaverine", "5-D-Glutamyl-D-glutamyl-peptide", "O-D-Alanyl-poly(ribitol phosphate)"]}, "target": "D-Amino acid metabolism"}
{"input": {"genes": ["AOC3", "DDC", "ALDH3A1", "PAH", "MAOB", "AOC2", "ALDH3B1", "HPD", "ALDH3B2", "GOT1", "GOT1L1"], "cpd": ["2-Hydroxy-3-phenylpropenoate", "3-Oxoadipyl-CoA", "cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol", "2-Hydroxyphenylacetate", "5-Carboxy-2-pentenoyl-CoA", "Succinyl-CoA", "trans-Cinnamate", "L-Phenylalanine", "Phenyllactate", "3-(3-Hydroxyphenyl)propanoic acid", "4-Hydroxyphenylacetate", "2,6-Dihydroxyphenylacetate"]}, "target": "Phenylalanine metabolism"}
{"input": {"genes": ["NAT2", "NAT1", "CYP2A7"], "cpd": ["N-Methylurea", "1-Methylxanthine", "1,3,7-Trimethyluric acid", "7-Methylxanthine", "7-Methylxanthosine", "3,6,8-Trimethylallantoin", "1,3,7-Trimethyl-5-hydroxyisourate", "N,N'-Dimethylurea", "3-Methylxanthine", "7-Methyluric acid", "Xanthine", "1,7-Dimethylxanthine", "Glyoxylate", "Theophylline", "Caffeine", "1,7-Dimethyluric acid", "Xanthosine"]}, "target": "Caffeine metabolism"}
{"input": {"genes": ["ALDH3A1", "GSTA1", "UGT1A7", "ADH4"], "cpd": ["10-Hydroxycarbazepine", "Felbamate (USPINN)", "2H-Dibenz[b,f]azepin-2-one", "Alcoifosfamide", "2-n-Propyl-4-pentenoic acid", "4-Hydroxy-2,6-dimethylaniline", "Cyclophosphamide", "Levomethadyl acetate (USAN)", "4-Ketoifosfamide"]}, "target": "Drug metabolism - cytochrome P450"}
{"input": {"genes": ["ADH5", "CYP2S1", "CYP2A13", "UGT1A6", "ALDH3B2", "AKR1C1", "UGT1A7", "CYP2B6", "ADH4", "CYP3A4", "UGT2B28", "MGST3", "CYP2A6", "ADH1A", "GSTT2", "CYP3A5", "UGT2B15", "GSTT4", "UGT2B4", "UGT2A3", "ADH7"], "cpd": ["Aflatoxin B1exo-8,9-epoxide-GSH", "1,2-Dibromoethane", "Aflatoxin B1", "S-(2-Hydroxyethyl)-N-acetyl-L-cysteine", "1,1-Dichloroethylene epoxide", "(1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene", "1-Nitronaphthalene-7,8-oxide", "9-Hydroxybenzo[a]pyrene-4,5-oxide", "1,2-Dihydronaphthalene-1,2-diol", "2,2-Dichloro-1,1-ethanediol"]}, "target": "Metabolism of xenobiotics by cytochrome P450"}
{"input": {"genes": ["CERK", "CERS5", "GLB1", "NEU3", "SPTLC3", "SPTLC2", "ACER2", "B4GALT5", "GAL3ST1", "UGT8", "SGPL1", "CERS2", "KDSR", "SMPD2", "SPHK1", "ASAH2", "CERS3", "PLPP3"], "cpd": ["Galactosylceramide", "GM4", "Ceramide 2-aminoethylphosphonate", "Lactosylceramide", "Palmitoyl-CoA", "Ceramide 1-phosphate", "L-Serine", "Sphinganine", "alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide", "Phytosphingosine", "Sphinganine 1-phosphate", "GA2", "Ceramide phosphoethanolamine", "GM3", "Lactosylceramide sulfate", "Sphingosine 1-phosphate", "N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide", "N-Acylsphingosine"]}, "target": "Sphingolipid metabolism"}
{"input": {"genes": ["DGKE", "PNLIPRP3", "AGPAT2", "GPAM", "ALDH2", "LPIN2"], "cpd": ["3-Phospho-D-glycerate", "UDP-6-sulfoquinovose", "Diglucosyldiacylglycerol", "1,2-Diacyl-3-beta-D-galactosyl-sn-glycerol", "1,2-Diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol", "Glycerone", "Triacylglycerol", "Fatty acid", "3-D-Glucosyl-1,2-diacylglycerol", "Acyl-CoA"]}, "target": "Glycerolipid metabolism"}
{"input": {"genes": ["DHFR2", "ST20-MTHFS", "FTCD", "TYMS", "MTHFD1L", "SHMT1"], "cpd": ["5-Methyltetrahydrofolate", "Folinic acid", "Tetrahydrofolate", "5,10-Methylenetetrahydrofolate"]}, "target": "One carbon pool by folate"}
{"input": {"genes": ["HKDC1", "GCK", "HK1"], "cpd": ["4'-Oxonebramine", "Kanamycin B", "2'-Dehydrokanamycin A"]}, "target": "Neomycin, kanamycin and gentamicin biosynthesis"}
{"input": {"genes": ["TXNRD3", "TXNRD1", "MTR", "SEPHS1", "CTH", "SEPHS2", "INMT", "PAPSS1", "TXNRD2", "SCLY"], "cpd": ["L-Selenocysteinyl-tRNA(Sec)", "Protein", "Glutathioselenol", "Dimethyl selenide"]}, "target": "Selenocompound metabolism"}
{"input": {"genes": ["IDH2", "GPT2", "BCAT1", "IDH3B", "ACO2", "CS", "ACO1", "DHTKD1", "OGDH", "IDH3G", "DLD", "PDHB", "BCAT2"], "cpd": ["(R)-(Homo)2-citrate", "(R)-Acetoin", "(S)-2-Aceto-2-hydroxybutanoate", "L-2,4-Diaminobutanoate", "Phenylpyruvate", "L-Isoleucine", "N-Acetyl-L-glutamate", "(E)-Phenylacetaldoxime", "2-Isopropylmaleate", "2-Benzylmalic acid", "Isocitrate", "L-Valine"]}, "target": "2-Oxocarboxylic acid metabolism"}
{"input": {"genes": ["VKORC1", "TAT", "NQO1", "COQ3", "COQ7", "COQ6", "COQ5"], "cpd": ["3-Demethylubiquinol", "3''-Hydroxy-geranylhydroquinone", "Phylloquinol", "gamma-Tocotrienol", "4-Hydroxybenzoyl-CoA", "alpha-Tocopherol", "3-Methoxy-4-hydroxy-5-polyprenylbenzoate", "2-Phytyl-1,4-naphthoquinone", "(R)-3-(4-Hydroxyphenyl)lactate", "Geranyl diphosphate", "6-Geranylgeranyl-2,3-dimethylbenzene-1,4-diol", "Cyclic dehypoxanthine futalosine", "Vitamin K1 epoxide", "Shikonin", "3-(4-Hydroxyphenyl)pyruvate", "6-Amino-6-deoxyfutalosine", "2,3-Epoxymenaquinone", "2-Methyl-6-solanyl-1,4-benzoquinol", "2-Succinylbenzoate", "3-[(1-Carboxyvinyl)oxy]benzoate", "4-(beta-D-Glucosyloxy)benzoate", "Phytyl diphosphate"]}, "target": "Ubiquinone and other terpenoid-quinone biosynthesis"}
{"input": {"genes": ["GLYCTK", "MDH1", "AMT", "MMUT", "ACSS1"], "cpd": ["Succinyl-CoA", "L-Glutamine", "Glycerone phosphate", "L-threo-3-Methylaspartate", "L-erythro-3-Methylmalyl-CoA", "2-Methylfumaryl-CoA", "cis-Aconitate", "2-Oxoglutarate", "(2S)-Ethylmalonyl-CoA", "Glycolaldehyde", "Formyl phosphate", "2-Hydroxy-3-oxosuccinate", "Ammonia", "Pentanoyl-CoA", "N-Formylderivatives", "Formyl-CoA", "Acetate", "meso-Tartaric acid", "L-Glutamate", "Hydrogen peroxide", "Glycolate", "2-Phospho-D-glycerate"]}, "target": "Glyoxylate and dicarboxylate metabolism"}
{"input": {"genes": ["LBR", "LSS", "SC5D", "CYP51A1"], "cpd": ["4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol", "trans,trans-Farnesyl diphosphate", "24-epi-Campesterol", "Cholesterol", "3-Keto-4-methylzymosterol", "Brassicasterol", "3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylate", "4alpha-Methylzymosterol", "14-Demethyllanosterol"]}, "target": "Steroid biosynthesis"}
{"input": {"genes": ["LPL", "DGKG", "MOGAT1", "AGPAT1", "PNPLA2", "GLYCTK", "PLPP3", "TKFC", "MGLL", "GPAT4", "PLPP2", "ABHD16A", "DGKQ"], "cpd": ["D-Glycerate", "Lipoteichoic acid", "D-Glucose 1-phosphate", "3-D-Glucosyl-1,2-diacylglycerol", "sn-Glycerol 3-phosphate", "Acyl-CoA", "Fatty acid", "Triacylglycerol"]}, "target": "Glycerolipid metabolism"}
{"input": {"genes": ["VARS2", "CARS1", "MT-TP", "AARS1", "MARS1", "YARS2", "MTFMT", "MT-TF", "QRSL1", "VARS1", "HARS2", "MT-TR"], "cpd": ["O-Phospho-L-serine", "L-Histidyl-tRNA(His)", "L-Serine", "Glycyl-tRNA(Gly)", "L-Tryptophan", "L-Tyrosyl-tRNA(Tyr)"]}, "target": "Aminoacyl-tRNA biosynthesis"}
{"input": {"genes": ["NFS1", "AK5", "NTPCR", "AK8", "ALPP", "ALPG", "AK1", "ACP1", "ALPL", "THTPA", "AK7", "AK2", "TPK1", "AK4", "ALPI"], "cpd": ["[Enzyme]-cysteine", "Thiamine acetic acid", "Thiocarboxy-[sulfur-carrier protein]", "Pyridoxal phosphate", "Thiamine aldehyde", "1-Deoxy-D-xylulose 5-phosphate", "NAD+", "Glycine", "4-Amino-5-aminomethyl-2-methylpyrimidine", "Thiamin triphosphate", "Thiamine", "Aminoimidazole ribotide", "Thiamin diphosphate", "L-Cysteine", "4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate", "Glycine", "N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine", "4-Methyl-5-(2-phosphooxyethyl)thiazole"]}, "target": "Thiamine metabolism"}
{"input": {"genes": ["SIRT7", "ENPP3", "AOX1", "SARM1", "NUDT13", "NT5C1B", "NT5C2", "NMNAT1", "SIRT3", "QPRT", "ENPP1", "NMNAT3", "NMRK1", "NT5C", "NADSYN1", "NT5DC4", "SIRT5", "PNP", "NAMPT", "NAPRT", "BST1", "SIRT4", "NNMT", "NT5M"], "cpd": ["(S)-2-(Hydroxymethyl)glutarate", "2-Formylglutarate", "Nicotine", "4-Aminobutanoate", "Nicotinate", "4-Oxo-1-(3-pyridyl)-1-butanone", "Nicotinamide-beta-riboside", "Succinate", "(2R,3S)-2,3-Dimethylmalate", "Nicotinate D-ribonucleotide", "Nicotinurate", "(S)-6-Hydroxynicotine", "Nicotinamide", "Blue pigment", "6-Hydroxy-3-succinoylpyridine", "Maleamate", "Succinate semialdehyde"]}, "target": "Nicotinate and nicotinamide metabolism"}
{"input": {"genes": ["ENPP3", "BLVRB", "ENPP1", "FLAD1", "ACP5", "RFK", "ACP2"], "cpd": ["5-Amino-6-(5'-phosphoribosylamino)uracil", "7-Hydroxy-6-methyl-8-ribityllumazine", "2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one", "2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one", "Lumichrome"]}, "target": "Riboflavin metabolism"}
{"input": {"genes": ["UGT2B17", "RDH13", "RDH11", "UGT1A5", "UGT2A3", "CYP3A7", "DHRS4L2", "DHRS4", "LRAT", "CYP3A5", "CYP26B1"], "cpd": ["Retinol", "11-cis-Retinal", "all-trans-18-Hydroxyretinoic acid", "Metarhodopsin"]}, "target": "Retinol metabolism"}
{"input": {"genes": ["BCAT2", "GOT2", "OGDHL", "IDH3B", "GPT", "GPT2", "PDHB", "IDH3G", "DHTKD1", "CS", "DBT", "DLST", "AGXT", "OGDH", "AADAT", "ACY1", "IDH3A", "GOT1L1", "NAGS", "PDHA2", "IDH2", "ACO1", "PDHA1", "GOT1", "BCKDHB"], "cpd": ["2-Oxo-10-methylthiodecanoic acid", "2-Oxo-9-methylthiononanoic acid", "L-Aspartate", "(E)-4-Hydroxyphenylacetaldehyde oxime", "Dihomomethionine", "2-Methylpropyl glucosinolate", "Glucoberteroin", "(R)-2,3-Dihydroxy-3-methylpentanoate", "S-(4-Methylthiobutylthiohydroximoyl)-L-cysteine", "2-Oxo-7-methylthioheptanoic acid", "cis-(Homo)2-aconitate", "2-(6'-Methylthio)hexylmalic acid", "3-Hydroxy-3-methyl-2-oxobutanoic acid", "S-(Indolylmethylthiohydroximoyl)-L-cysteine", "(S)-2-Aminobutanoate", "N-Acetyl-L-glutamate", "9-Methylthiononanaldoxime"]}, "target": "2-Oxocarboxylic acid metabolism"}
{"input": {"genes": ["OXSM", "BTD"], "cpd": ["3-Hydroxypimeloyl-[acp] methyl ester", "Pimeloyl-[acyl-carrier protein]", "Bisnorbiotin", "8-Amino-7-oxononanoate", "Dethiobiotin", "Pimeloyl-CoA", "3-Ketopimeloyl-[acp] methyl ester", "Biotin sulfoxide", "Enoylglutaryl-[acp] methyl ester", "Biotin sulfone", "3-Hydroxyglutaryl-[acp] methyl ester", "7,8-Diaminononanoate"]}, "target": "Biotin metabolism"}
{"input": {"genes": ["OXSM", "BTD", "HLCS"], "cpd": ["Dethiobiotin", "Bisnorbiotin", "Long-chain acyl-[acyl-carrier protein]", "8-Amino-7-(carboxyamino)nonanoate", "Glutaryl-[acp] methyl ester", "Biotin", "3-Ketoglutaryl-[acp] methyl ester", "Biocytin", "Malonyl-[acyl-carrier protein]", "Tetranorbiotin", "3-Ketopimeloyl-[acp] methyl ester", "Pimelate", "Urea", "3-Hydroxyglutaryl-[acp] methyl ester", "7,8-Diaminononanoate", "Enoylglutaryl-[acp] methyl ester", "Pimeloyl-CoA", "Biotinyl-5'-AMP", "Pimeloyl-[acyl-carrier protein] methyl ester", "3-Hydroxypimeloyl-[acp] methyl ester", "Enoylpimeloyl-[acp] methyl ester", "L-Lysine", "8-Amino-7-oxononanoate", "Malonyl-[acp] methyl ester"]}, "target": "Biotin metabolism"}
{"input": {"genes": ["ALDH3B1", "DDC", "AOC3", "ALDH3B2", "HPD", "GOT1", "MAOA", "MIF"], "cpd": ["3-Oxo-5,6-dehydrosuberyl-CoA", "2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate", "Phenyllactate", "Phenethylamine", "trans-2,3-Dihydroxycinnamate", "2-Oxepin-2(3H)-ylideneacetyl-CoA", "Fumarate", "L-Phenylalanine", "Pyruvate", "2-Phenylacetamide", "2-Hydroxy-2,4-pentadienoate", "trans-Cinnamate", "Acetaldehyde", "Phenylacetylglutamine", "3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde", "Phenylpyruvate", "3-(2,3-Dihydroxyphenyl)propanoate"]}, "target": "Phenylalanine metabolism"}
{"input": {"genes": ["MGST3", "GSTA4", "GSTT2"], "cpd": ["Aflatoxin B1exo-8,9-epoxide-GSH", "Aflatoxin B1-endo-8,9-epoxide", "Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide", "(1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid", "Chloral", "1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol", "1,2-Naphthoquinone", "alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol", "5-(3-Pyridyl)-2-hydroxytetrahydrofuran", "Aflatoxin B1-exo-8,9-epoxide", "3-Succinoylpyridine", "7-Hydroxymethyl-12-methylbenz[a]anthracene"]}, "target": "Metabolism of xenobiotics by cytochrome P450"}
{"input": {"genes": ["TYR", "ADH7", "TPO", "LRTOMT", "DBH"], "cpd": ["N-Methyltyramine", "L-Adrenaline", "3-Methoxytyramine", "L-Tyrosine", "Tyramine", "(R)-3-(4-Hydroxyphenyl)lactate", "3-(4-Hydroxyphenyl)pyruvate", "Dopamine", "2-Oxohept-3-enedioate", "4-Hydroxyphenylacetaldehyde", "4-Hydroxyphenylethanol", "2-Hydroxyhepta-2,4-dienedioate", "Succinate semialdehyde"]}, "target": "Tyrosine metabolism"}
{"input": {"genes": ["BAAT", "GAD1", "ADO", "FMO2", "GGT6", "FMO5", "GGT1", "GAD2", "GGT5", "FMO3", "GGT7"], "cpd": ["L-Glutamate", "Hypotaurine", "Cysteamine", "5-L-Glutamyl-taurine", "L-Cysteine", "L-Alanine", "N-Phosphotaurocyamine", "2-Oxoglutarate", "2-Hydroxyethanesulfonate"]}, "target": "Taurine and hypotaurine metabolism"}
{"input": {"genes": ["AOX1", "BST1", "CD38", "PNP", "NMNAT1", "NNT", "SIRT2", "NUDT13", "NT5C1A", "QPRT", "SIRT5", "NMRK1", "NMNAT2", "SIRT7", "NADSYN1"], "cpd": ["(R)-6-Hydroxynicotine", "N-Methylmyosmine"]}, "target": "Nicotinate and nicotinamide metabolism"}
{"input": {"genes": ["CYP3A5", "HSD3B2", "HSD17B11", "UGT2B17", "UGT1A7", "SRD5A2", "HSD17B6", "CYP2E1", "HSD17B7"], "cpd": ["21-Hydroxypregnenolone", "20alpha-Hydroxycholesterol", "7alpha-Hydroxytestosterone", "Androstan-3alpha,17beta-diol", "4-Methylpentanal", "17alpha,21-Dihydroxypregnenolone", "Cortolone", "7alpha-Hydroxyandrost-4-ene-3,17-dione", "Corticosterone", "11beta-Hydroxyandrost-4-ene-3,17-dione", "3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al", "Pregnanolone", "Allotetrahydrodeoxycorticosterone", "19-Hydroxyandrost-4-ene-3,17-dione", "Progesterone"]}, "target": "Steroid hormone biosynthesis"}
{"input": {"genes": ["SUCLG1", "PDHB", "GPI", "PGAM1", "ALDOB", "PGAM4", "IDH3A", "ALDOC", "TALDO1", "PGK2", "ACOX3", "PFKL", "ACSS1", "PFKM", "PGAM2", "SHMT2", "GOT1", "FBP2", "ACO1", "GLUD1", "ACO2", "HK1", "HKDC1"], "cpd": ["O-Phospho-L-serine", "4-Hydroxybutyryl-CoA", "(2R)-Ethylmalonyl-CoA", "Sedoheptulose 1,7-bisphosphate", "Acetoacetyl-CoA", "Carbamoyl phosphate"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["ACAT2", "TPI1", "HK1", "SUCLA2", "DLAT", "SUCLG1", "GCK", "ACOX3", "PHGDH", "GAPDH", "FBP2", "HKDC1", "SDHC", "ME3", "ME1", "PGK1", "PC"], "cpd": ["Propanoyl-CoA", "L-Cysteine", "Oxaloacetate", "Pyruvate", "L-threo-3-Methylaspartate", "(S)-Malate", "Methane", "Glyoxylate", "D-Fructose 6-phosphate", "10-Formyltetrahydrofolate", "Propenoyl-CoA", "3-Hydroxypropanoate", "(3S)-Citramalyl-CoA", "Coenzyme M", "2-Methylfumaryl-CoA", "D-Glyceraldehyde 3-phosphate", "2-Phosphoglycolate", "Acetate", "Acetyl phosphate", "2-(Methylthio)ethanesulfonate"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["ADH5", "PGK2", "ENO4", "ENO1", "GAPDH", "GLUD2"], "cpd": ["Propenoyl-CoA", "3-Hydroxypropanoate", "Dimethylamine", "(S)-Methylmalonyl-CoA", "D-Gluconic acid", "Glycerone", "(3S)-Citryl-CoA"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["HK1", "TKFC", "GOT1L1", "GPT2", "MDH2", "FBP1", "SDHD", "PDHA2", "", "PHGDH", "RGN", "SDHB", "TPI1", "ESD", "ADPGK", "PFKL", "HKDC1", "ALDOA", "CAT", "IDH3G", "IDH3B"], "cpd": ["3-Oxopropanoate", "5,10-Methylenetetrahydromethanopterin", "Hydroxypyruvate", "CO2", "D-Ribose 5-phosphate", "Acetoacetyl-CoA", "Dimethylamine", "Acetate", "2-Phosphoglycolate", "5-Methyl-H4SPT", "alpha-D-Glucose", "Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide", "3-Methylfumaryl-CoA", "Ammonia", "Butanoyl-CoA", "Succinate semialdehyde", "Hydrogen sulfide", "L-Serine", "10-Formyltetrahydrofolate", "Methane", "D-Xylulose 5-phosphate", "Isocitrate", "2-(Methylthio)ethanesulfonate", "D-arabino-Hex-3-ulose 6-phosphate"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["SUCLG1", "PGAM4", "ENO4", "DLST", "ACADS", "PRPS1", "IDH3B", "MCEE", "SHMT1", "TPI1", "PGD", "RPIA", "GOT2"], "cpd": ["L-Malyl-CoA", "D-Glycerate", "Carbamoyl phosphate", "5,10-Methylenetetrahydrofolate", "2-Phospho-D-glycerate", "L-Serine", "O-Phospho-L-serine", "Malonyl-CoA", "(S)-Methylmalonyl-CoA", "6-Phospho-D-gluconate", "3-Phospho-D-glyceroyl phosphate", "4-Hydroxybutyryl-CoA", "O-Acetyl-L-serine", "Pyruvate", "D-Xylulose 5-phosphate", "Trimethylamine", "Tetrahydrofolate"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["ACAT2", "RPEL1", "GPT2", "GLDC", "PRPS1L1", "PCCB", "IDH3G", "PDHA2", "SDHB", "IDH1", "GCSH", "PFKL", "PSPH", "GOT1L1", "SDSL", "ACOX3", "PC", "IDH3A", "HKDC1", "GLUD2", "HAO2", "PCCA", "PRPS2", "ENO1", "PGAM1"], "cpd": ["6-Phospho-D-gluconate", "10-Formyltetrahydrofolate", "L-erythro-3-Methylmalyl-CoA"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["IDH2", "GLDC", "PFKP", "PGAM4", "ACO1", "ALDOC", "PDHB", "H6PD", "AGXT", "SUCLA2", "SDHC", "ACSS1", "PSPH", "PKLR", "PGK2", "PGK1"], "cpd": ["D-Glucono-1,5-lactone 6-phosphate", "(2S)-Methylsuccinyl-CoA", "Sedoheptulose 7-phosphate", "beta-D-Glucose 6-phosphate", "5,10-Methenyltetrahydrofolate", "Glycerone", "Acetyl-CoA", "Formate", "5,10-Methylenetetrahydromethanopterin", "D-Erythrose 4-phosphate", "3-Methylfumaryl-CoA", "2-Oxoglutarate", "Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide", "3-Hydroxypropanoate", "CO2", "L-Cysteine", "D-Xylulose 5-phosphate", "Oxaloacetate", "D-Fructose 1,6-bisphosphate", "D-arabino-Hex-3-ulose 6-phosphate", "(2R)-Ethylmalonyl-CoA", "3-Phospho-D-glyceroyl phosphate", "(R)-Methylmalonyl-CoA", "Ammonia"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["SDHD", "PSPH", "IDH1", "FH", "PGK2", "SHMT1", "ACOX3", "GCK", "PRPS2", "CPS1", "ACADS", "ME3", "ENO3", "DLD", "SDS"], "cpd": ["(R)-Methylmalonyl-CoA", "(2S)-Methylsuccinyl-CoA", "alpha-D-Glucose", "Dimethylamine", "(2R)-Ethylmalonyl-CoA", "D-Xylulose 5-phosphate", "Methane", "Glyoxylate", "L-Aspartate", "3-Phospho-D-glycerate", "D-Fructose 1,6-bisphosphate", "Pyruvate", "D-Ribulose 5-phosphate"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["CPS1", "SDHB", "PDHA2"], "cpd": ["2-Oxoglutarate", "Tetrahydrofolate", "(S)-3-Hydroxybutanoyl-CoA", "Acetyl-CoA", "(R)-3-Hydroxybutanoyl-CoA", "4-Hydroxybutyryl-CoA"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["HK2", "ACAT2", "PRPS1L1", "ENO1", "PKLR", "ME3", "PRPS1"], "cpd": ["Tetrahydrofolate", "Succinate semialdehyde", "Acetoacetyl-CoA", "3-Phospho-D-glyceroyl phosphate", "5,10-Methylenetetrahydromethanopterin", "O-Acetyl-L-serine", "D-Ribulose 1,5-bisphosphate", "Mesaconate", "2-Phospho-D-glycerate", "4-Hydroxybutanoic acid", "L-Cysteine", "Acetyl-CoA", "D-Glyceraldehyde 3-phosphate", "5-Methyl-5,6,7,8-tetrahydromethanopterin"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["PHGDH", "ENO1", "ME2", "HK2", "DLD", "SUCLG2", "PGD", "IDH2", "SDHB", "GOT1", "TKTL1", "OGDHL", "SHMT2", "ALDH6A1", "RPEL1", "AGXT", "HK3", "ACSS1", "PGAM2", "ECHS1", "PSAT1"], "cpd": ["Formate", "Trimethylamine", "alpha-D-Glucose", "(2S)-Methylsuccinyl-CoA", "D-Glyceraldehyde 3-phosphate", "Coenzyme M", "3-Phospho-D-glycerate", "(3S)-Citryl-CoA", "5,10-Methenyltetrahydrofolate", "Glycolate", "Glyoxylate", "Acetyl phosphate", "Succinyl-CoA", "10-Formyltetrahydrofolate", "Glycerone", "Crotonoyl-CoA", "2-Oxoglutarate", "(R)-Methylmalonyl-CoA"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["GLYCTK", "TKTL1", "RPEL1", "SUCLA2", "IDNK", "PGAM1", "PDHB", "ALDOC", "PKM", "FH", "ACOX3", "IDH2", "PHGDH", "SDHB", "SHMT1", "TKT", "PGK2", "G6PD"], "cpd": ["5-Methyltetrahydrofolate", "2-Oxoglutarate", "Coenzyme B", "Ammonia", "Tetrahydrofolate", "L-erythro-3-Methylmalyl-CoA", "Propanoyl-CoA", "Sedoheptulose 1,7-bisphosphate"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["HAO1", "TPI1", "ECHS1", "PGAM2", "DLD", "MMUT", "TALDO1", "OGDH", "RGN", "HAO2", "ACO1", "GPT2", "FBP2", "HK2", "PCCB", "FH", "SHMT2", "AMT", "IDH1", "PFKL", "ALDOB"], "cpd": ["D-Xylulose 5-phosphate", "Hydrogen sulfide", "Methanol", "Methane"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["PGK1", "GOT2", "PFKP", "HK2", "PRPS1", "TALDO1"], "cpd": ["Propanoyl-CoA", "3-Hydroxypropionyl-CoA", "Glyoxylate", "3-Hydroxypropanoate", "Acetate", "2-Oxoglutarate", "5,10-Methenyltetrahydrofolate", "Carbamoyl phosphate", "Fumarate", "3-Phospho-D-glycerate", "(S)-Methylmalonyl-CoA", "Citrate", "Coenzyme M", "CO", "Methane", "L-Cysteine", "Succinate semialdehyde", "L-Serine", "L-threo-3-Methylaspartate", "Formaldehyde", "10-Formyltetrahydrofolate"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["SUCLG1", "SHMT2", "ME1", "CPS1", "PGAM4", "PSPH", "PRPS2", "ACO1", "SDS", "ALDH6A1", "RGN", "PCCA", "GOT1", "GPT", "IDH2", "ACAT2", "PGD", "AMT"], "cpd": ["Fumarate", "5,10-Methylenetetrahydrofolate", "alpha-D-Glucose 6-phosphate"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["HKDC1", "ALDOB"], "cpd": ["D-Glyceraldehyde", "2-(Methylthio)ethanesulfonate", "D-Xylulose 5-phosphate", "Acetoacetyl-CoA", "Acetate", "D-Glucono-1,5-lactone 6-phosphate", "Tetrahydrosarcinapterin", "beta-D-Glucose 6-phosphate", "L-Cysteine", "(3S)-Citryl-CoA", "3-Hydroxypropionyl-CoA", "D-arabino-Hex-3-ulose 6-phosphate", "5-Methyl-5,6,7,8-tetrahydromethanopterin", "10-Formyltetrahydrofolate", "Phosphoenolpyruvate", "(S)-Malate"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["ACSS1", "PGK2", "SDS", "PFKM", "H6PD", "ME3"], "cpd": ["D-Gluconic acid", "5,10-Methylenetetrahydromethanopterin", "Tetrahydrosarcinapterin", "L-Cysteine", "4-Hydroxybutanoic acid", "D-Erythrose 4-phosphate", "D-Fructose 1,6-bisphosphate", "Propanoyl-CoA", "beta-D-Glucose", "2-Dehydro-3-deoxy-6-phospho-D-gluconate", "Fumarate", "alpha-D-Glucose 6-phosphate", "3-Phospho-D-glyceroyl phosphate", "5,10-Methenyltetrahydromethanopterin", "5,6,7,8-Tetrahydromethanopterin", "L-erythro-3-Methylmalyl-CoA"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["PFKL", "SDHA", "RPE", "PGD", "SUCLG1", "PDHA1", "TPI1", "OGDHL", "HK1", "PFKP", "PGAM2", "ACADS", "ME1"], "cpd": ["D-Fructose 1,6-bisphosphate", "2-Dehydro-3-deoxy-6-phospho-D-gluconate", "Propenoyl-CoA", "D-Xylulose 5-phosphate", "L-Serine", "2-Dehydro-3-deoxy-D-gluconate", "5-Methyl-H4SPT", "Coenzyme B", "Trimethylamine"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["ADPGK", "ALDOB", "RPEL1", "GCK"], "cpd": ["5,6,7,8-Tetrahydromethanopterin", "Tetrahydrosarcinapterin", "Formamide", "Acetoacetyl-CoA", "Pyruvate", "Glycine", "beta-D-Glucose 6-phosphate", "3-Phospho-D-glycerate", "2-Phosphoglycolate", "(2S)-Methylsuccinyl-CoA", "D-Ribulose 1,5-bisphosphate", "Methylamine", "Hydroxypyruvate", "alpha-D-Glucose 6-phosphate", "Butanoyl-CoA", "5-Methyl-5,6,7,8-tetrahydromethanopterin", "Hydrogen sulfide", "Acetyl phosphate", "(2R)-Ethylmalonyl-CoA", "5-Formyl-5,6,7,8-tetrahydromethanopterin", "2-Phospho-D-glycerate", "L-Alanine", "3-Hydroxypropionyl-CoA"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["ALDH6A1", "GLUD2", "PDHB", "OGDHL", "PRPS1L1", "PRPS1", "CPS1", "ACAT1", "HAO2", "PKLR", "GOT1", "ADPGK", "PGAM1", "IDH3A", "IDH1", "TKT", "HAO1", "PGP", "RGN", "OGDH"], "cpd": ["D-Ribose 5-phosphate", "alpha-D-Glucose 6-phosphate", "Acetyl phosphate", "Coenzyme B", "Glycolate", "3-Hydroxypropanoate", "5,10-Methenyltetrahydromethanopterin", "D-arabino-Hex-3-ulose 6-phosphate", "2-Dehydro-3-deoxy-D-gluconate", "Formamide", "(R)-Methylmalonyl-CoA"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["ENO4", "RPIA", "ACOX3", "GPI", "AGXT", "FBP1", "PGAM1", "PCCB", "DLD"], "cpd": ["L-Serine", "(2R)-Ethylmalonyl-CoA", "L-Aspartate", "CO2", "5-Methyl-5,6,7,8-tetrahydromethanopterin", "Succinyl-CoA", "Glycerone", "Carbamoyl phosphate", "Glyoxylate"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["GLDC", "PGLS", "MDH2", "PDHA2", "GAPDH", "HAO1", "ECHS1", "ME2", "HK2", "PDHA1", "IDH1", "GLYCTK", "PRPS1L1", "ACOX1", "IDH3G", "DLD", "PDHB"], "cpd": ["Citrate", "Formylmethanofuran", "Acetyl phosphate", "Phosphoenolpyruvate", "alpha-D-Glucose", "3-Oxopropanoate", "3-Hydroxypropionyl-CoA", "D-arabino-Hex-3-ulose 6-phosphate", "Tetrahydrofolate", "2-Phospho-D-glycerate", "D-Ribose 5-phosphate", "Sedoheptulose 1,7-bisphosphate", "D-Xylulose 5-phosphate", "(2R)-Ethylmalonyl-CoA", "D-Glucono-1,5-lactone 6-phosphate", "L-Alanine"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["HK3", "IDH1", "PDHA2", "GOT1", "PCCB", "DLD", "GOT2"], "cpd": ["Isocitrate", "5-Methyl-5,6,7,8-tetrahydromethanopterin", "4-Hydroxybutyryl-CoA", "D-Gluconic acid", "Acetoacetyl-CoA", "2-Methylfumaryl-CoA", "3-Hydroxypropionyl-CoA", "Methane", "3-Phosphonooxypyruvate", "2-Phospho-D-glycerate", "Citrate", "Methylamine", "CO", "Pyruvate", "Butanoyl-CoA", "Sedoheptulose 1,7-bisphosphate", "Formaldehyde", "5,6,7,8-Tetrahydromethanopterin", "Formylmethanofuran", "L-Serine"]}, "target": "Carbon metabolism"}
{"input": {"genes": ["ADH5", "SHMT2", "IDH3G", "RGN", "IDH1", "H6PD", "FBP2"], "cpd": ["alpha-D-Glucose 6-phosphate", "5-Methyl-5,6,7,8-tetrahydromethanopterin", "Pyruvate", "Dimethylamine", "(3S)-Citryl-CoA", "CO", "Oxaloacetate", "Sedoheptulose 7-phosphate", "(2R)-Ethylmalonyl-CoA", "3-Phospho-D-glyceroyl phosphate", "5,10-Methylenetetrahydromethanopterin", "6-Phospho-D-gluconate", "Trimethylamine", "Phosphoenolpyruvate"]}, "target": "Carbon metabolism"}