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FL.20 (S:456L) lineage with S:L455W with possibly high prevalence in northern ireland (11 sequences) #2145

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BorisUitham opened this issue Jul 26, 2023 · 0 comments
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@BorisUitham
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BorisUitham commented Jul 26, 2023

GISAID and covspectrum Query: G21718C, T22928C, C25714T, T22926G
Defining mutations: FL.20 >> S:L455W (T22926G)
First sequence: 05-17 (northern ireland)
Newest sequence: 06-29 (northern ireland)

England was the first to submit sequences, and there was an airport sequence in the USA from a traveller in the UK, but it seems now that this is most prevalent in northern ireland, which does not submit a lot of sequences. But retrospectively the earliest sequence seems to be from N.I too.

Since 1st of june, it comprises 7 out of 38 sequences (18.4%), or 6 out of 16 sequences since 18th of june (37.5%) in northern ireland.

Some discussion about the effects of W455 here: sars-cov-2-variants/lineage-proposals#95 (comment)
In summary, it was probably more beneficial on a ba.2 backbone than xbb.1.5, possibly due to R493 presence. However, the presence of 456L might change these predictions again (as 455F is also negative in these predictions unlike what we are seeing in lineages with 456L)

Usher trees
fl20new
It also seems to have become the biggest branch of FL.20:
fl20new2
https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_1b75b_1474d0.json?c=gt-S_455

EPI_ISL_17812682, EPI_ISL_17884493, EPI_ISL_17950363,
EPI_ISL_17980490-17980492, EPI_ISL_18041202, EPI_ISL_18041205,
EPI_ISL_18041207-18041208, EPI_ISL_18041211

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