diff --git a/lineage_notes.txt b/lineage_notes.txt
index 56922723..f730db38 100644
--- a/lineage_notes.txt
+++ b/lineage_notes.txt
@@ -1246,6 +1246,8 @@ JN.1.15	Alias of B.1.1.529.2.86.1.1.15, S:A688V
 JN.1.15.1	Alias of B.1.1.529.2.86.1.1.15.1, S:F456L, ORF3a:R122S, Ecuador, from sars-cov-2-variants/lineage-proposals#1253
 LU.1	Alias of B.1.1.529.2.86.1.1.15.1.1, S:R346T, after C19269T, from sars-cov-2-variants/lineage-proposals#1089
 LU.2	Alias of B.1.1.529.2.86.1.1.15.1.2, S:R346T, after T20865C, from sars-cov-2-variants/lineage-proposals#1652
+LU.2.1	Alias of B.1.1.529.2.86.1.1.15.1.2.1, S:L176F, Ecuador
+LU.2.1.1	Alias of B.1.1.529.2.86.1.1.15.1.2.1.1, S:S60P, S:K182N, ORF1a:L204F, ORF1a:T1854I, Ecuador
 JN.1.16	Alias of B.1.1.529.2.86.1.1.16, S:F456L (T22928C), from sars-cov-2-variants/lineage-proposals#1253
 JN.1.16.1	Alias of B.1.1.529.2.86.1.1.16.1, S:R346T, from sars-cov-2-variants/lineage-proposals#1089
 LF.1	Alias of B.1.1.529.2.86.1.1.16.1.1, ORF1a:A1268T, ORF1a:S2103F
@@ -1262,6 +1264,7 @@ JN.1.16.2	Alias of B.1.1.529.2.86.1.1.16.2, C4777T, from sars-cov-2-variants/lin
 LA.1	Alias of B.1.1.529.2.86.1.1.16.2.1, S:R346T, from sars-cov-2-variants/lineage-proposals#1253
 LA.2	Alias of B.1.1.529.2.86.1.1.16.2.2, S:R346I, from sars-cov-2-variants/lineage-proposals#1089
 JN.1.16.3	Alias of B.1.1.529.2.86.1.1.16.3, S:T572I
+JN.1.16.4	Alias of B.1.1.529.2.86.1.1.16.4, S:Q493E, ORF1a:G400S, ORF7a:F59K, East Asia
 JN.1.17	Alias of B.1.1.529.2.86.1.1.17, S:A222V, USA
 JN.1.18	Alias of B.1.1.529.2.86.1.1.18, S:R346T, directly on JN.1 polytomy, from sars-cov-2-variants/lineage-proposals#1089
 JN.1.18.1	Alias of B.1.1.529.2.86.1.1.18.1, S:T250N, from sars-cov-2-variants/lineage-proposals#1414
diff --git a/lineages.csv b/lineages.csv
index f0bb1c8f..ffed168c 100644
--- a/lineages.csv
+++ b/lineages.csv
@@ -2559767,11 +2559767,6 @@ USA/NJ-CDC-QDX97356862/2024,LU.2
 USA/NY-PRL-240521_81C03/2024,LU.2
 USA/NY-PRL-240529_81F03/2024,LU.2
 USA/NY-NYULH-19453/2024,LU.2
-Ecuador/GENSBIO-INSPI-CI-76-Q/2024,LU.2
-Ecuador/GENSBIO-INSPI-1812-8228/2024,LU.2
-USA/FL-GBW-GKISBBBC48195/2024,LU.2
-USA/FL-GBW-GKPLAAAA20731/2024,LU.2
-USA/NE-NM_L378163550/2024,LU.2
 USA/CO-CDPHE-41969161/2024,LU.2
 USA/2024CV0810/2024,LU.2
 USA/AZ-ASPHL-0810/2024,LU.2
@@ -2565171,3 +2565166,50 @@ USA/TX-HMH-M-142501/2024,JN.1.59.1
 USA/TX-HMH-M-141743/2024,JN.1.59.1
 Puerto_Rico/PR-CVL-025024/2024,JN.1.59.1
 USA/PR-CVL-025024/2024,JN.1.59.1
+USA/CA-GBW-GKPLAAAA33666/2024,JN.1.16.4
+USA/CA-GBW-GKISBBBD11604/2024,JN.1.16.4
+USA/NY-GBW-GKISBBBD56133/2024,JN.1.16.4
+Singapore/R44MQ36/2024,JN.1.16.4
+Singapore/R40MQ10/2024,JN.1.16.4
+Singapore/R45MQ56/2024,JN.1.16.4
+Taiwan/CDC-W38868/2024,JN.1.16.4
+South_Korea/KDCA293715/2024,JN.1.16.4
+SouthKorea/KDCA293715/2024,JN.1.16.4
+USA/NY-NPHL-240723_82H08/2024,JN.1.16.4
+USA/NY-PRL-240723_82H08/2024,JN.1.16.4
+Taiwan/CDC-W38598/2024,JN.1.16.4
+Canada/ON-PHL-202410220/2024,JN.1.16.4
+Taiwan/CDC-W38837/2024,JN.1.16.4
+Canada/ON-PHL-202410998/2024,JN.1.16.4
+Japan/EIS10-322/2024,JN.1.16.4
+USA/CA-GBW-GKPLAAAA15351/2024,JN.1.16.4
+USA/CA-GBW-GKISBBBC87813/2024,JN.1.16.4
+USA/OH-PLMI-6J2-25425/2024,LU.2.1
+Ecuador/NIC-INSPI-0875-10861/2024,LU.2.1
+Ecuador/NIC-INSPI-0875-10913/2024,LU.2.1
+Ecuador/GENSBIO-INSPI-1812-8228/2024,LU.2.1
+Ecuador/GENSBIO-INSPI-CI-76-Q/2024,LU.2.1
+Ecuador/GENSBIO-INSPI-105486/2024,LU.2.1
+Ecuador/GENSBIO-INSPI-105496/2024,LU.2.1
+Ecuador/GENSBIO-INSPI-105500/2024,LU.2.1
+Ecuador/GENSBIO-INSPI-105494/2024,LU.2.1
+Ecuador/GENSBIO-INSPI-105495/2024,LU.2.1
+Ecuador/GENSBIO-INSPI-105467/2024,LU.2.1.1
+Ecuador/NIC-INSPI-435353/2024,LU.2.1.1
+USA/MI-UM-L378585755/2024,LU.2.1.1
+Sweden/H-24-065737/2024,LU.2.1.1
+Sweden/H-24-065757/2024,LU.2.1.1
+Denmark/DCGC-687705/2024,LU.2.1.1
+Belgium/Sciensano-LS-S5503/2024,LU.2.1.1
+Scotland/CLIMB-CM7YEIAC/2024,LU.2.1.1
+USA/MIS-L378585755/2024,LU.2.1.1
+Denmark/DCGC-686974/2024,LU.2.1.1
+USA/FL-GBW-GKPLAAAA20731/2024,LU.2.1.1
+USA/FL-GBW-GKISBBBC48195/2024,LU.2.1.1
+USA/NE-NM_L378163550/2024,LU.2.1.1
+USA/NY-CDC-LC1111710/2024,LU.2.1.1
+Spain/AS-HUCA-232459069/2024,LU.2.1.1
+USA/UT-UPHL-240802415254/2024,LU.2.1.1
+Scotland/CLIMB-CM7YJTKG/2024,LU.2.1.1
+USA/NC-CDC-LC1108584/2024,LU.2.1.1
+USA/NY-URMC-O7S1P815-1/2024,LU.2.1.1